PRB3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PRB3
Entrez Gene ID	5544
Full Name	proline rich protein BstNI subfamily 3
Synonyms	G1,PRG
General protein information	Preferred Names proline rich protein BstNI subfamily 3 Names basic salivary proline-rich protein 3 BstNI type basic salivary proline-rich protein 3 G1 parotid salivary glycoprotein parotid salivary glycoprotein G1 proline-rich protein G1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p13.2
Summary	This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats have been identified. The reference genome encodes the 'Long' allele. The protein isoforms encoded by this gene are recognized as the 'first line of oral defense' against the detrimental effects of polyphenols in the diet and pathogen infections. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, Nov 2015].
Disorder MIM:	168840

mRNA and Protein(s)

mRNA	Protein	Name
NM_006249.5	NP_006240.4	basic salivary proline-rich protein 3 precursor

Pathways from BioSystems

Homologies

	LOC695018	XP_001083663.1
Homo sapiens (human)	PRB3	NP_006240.4
Pan troglodytes (chimpanzee)	PRB3	XP_001137791.3

Gene Ontology
Bibliography

Related articles in PubMed

The intriguing heterogeneity of human salivary proline-rich proteins: Short title: Salivary proline-rich protein species.
Manconi B, Castagnola M, Cabras T, Olianas A, Vitali A, Desiderio C, Sanna MT, Messana I
Journal of proteomics13447-56(2016 Feb)

Low levels of PRB3 mRNA are associated with dopamine-agonist resistance and tumor recurrence in prolactinomas.
Wang F, Gao H, Li C, Bai J, Lu R, Cao L, Wu Y, Hong L, Wu Y, Lan X, Zhang Y
Journal of neuro-oncology116(1)83-8(2014 Jan)

Finding new posttranslational modifications in salivary proline-rich proteins.
Vitorino R, Alves R, Barros A, Caseiro A, Ferreira R, Lobo MC, Bastos A, Duarte J, Carvalho D, Santos LL, Amado FL
Proteomics10(20)3732-42(2010 Oct)

Identification of Lys-Pro-Gln as a novel cleavage site specificity of saliva-associated proteases.
Helmerhorst EJ, Sun X, Salih E, Oppenheim FG
The Journal of biological chemistry283(29)19957-66(2008 Jul)

PRB3 null mutations result in absence of the proline-rich glycoprotein Gl and abolish Fusobacterium nucleatum interactions with saliva in vitro.
Azen E, Prakobphol A, Fisher SJ
Infection and immunity61(10)4434-9(1993 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results of this study suggested that low levels of PRB3 mRNA may have a role in dopamine-agonist resistance and tumor recurrence of prolactinomas.
Title: Low levels of PRB3 mRNA are associated with dopamine-agonist resistance and tumor recurrence in prolactinomas.

The following PRB3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PRB3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu27957	NM_006249.5 Latest version!	Homo sapiens proline rich protein BstNI subfamily 3 (PRB3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PRB3 ( NM_006249.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_006240.4 Homo sapiens proline rich protein BstNI subfamily 3 (PRB3), mRNA.

Price & Availability↑

CloneID	OHu27957
Clone ID Related Accession (Same CDS sequence)	NM_006249.5
Accession Version	NM_006249.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 930bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Homo sapiens(human)
Product	basic salivary proline-rich protein 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC010176.12 and AC244131.2. This sequence is a reference standard in the RefSeqGene project. On Apr 24, 2014 this sequence version replaced NM_006249.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC096211.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2150585, SAMN03465412 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTACTGA TTCTGCTGTC GGTGGCCCTG CTGGCCCTGA GCTCAGCTCA GAGCTTAAAT 
GAAGATGTCA GCCAGGAAGA ATCTCCCTCC GTAATATCAG GAAAGCCAGA AGGACGACGC 
CCACAAGGAG GAAACCAGCC CCAACGTACC CCACCTCCTC CAGGAAAGCC AGAAGGACGA 
CCCCCACAAG GAGGCAACCA GTCCCAAGGT CCCCCACCTC GTCCAGGAAA GCCAGAAGGA 
CCACCCCCAC AAGGAGGAAA CCAGTCCCAA GGTCCCCCAC CTCGTCCGGG AAAGCCAGAA 
GGACAACCCC CACAAGGAGG AAACCAGTCC CAAGGTCCCC CACCTCGTCC GGGAAAGCCA 
GAAGGACCAC CCCCACAAGG AGGAAACCAG TCCCAAGGTC CCCCGCCTCG TCCGGGAAAG 
CCAGAAGGAC CACCCCCACA AGGAGGAAAC CAGTCCCAAG GTCCCCCGCC TCGTCCGGGA 
AAGCCAGAAG GACCACCCCC ACAAGGAGGA AACCAGTCCC AAGGTCCCCC GCCTCATCCG 
GGAAAGCCAG AAGGACCACC CCCACAAGGA GGAAACCAGT CCCAAGGTCC CCCACCTCGT 
CCGGGAAAGC CAGAAGGACC ACCCCCACAA GGAGGAAACC AGTCCCAAGG TCCCCCACCT 
CGTCCAGGAA AGCCAGAAGG ACCACCTTCA CAAGGAGGCA ACAAACCTCA AGGTCCCCCA 
CCTCATCCAG GAAAGCCACA AGGACCACCC CCACAAGAAG GTAACAAACC TCAACGTCCC 
CCTCCTCCAG GAAGGCCACA AGGACCACCC CCACCAGGAG GCAATCCCCA GCAGCCTCTG 
CCACCTCCCG CTGGAAAGCC CCAGGGACCA CCTCCACCTC CTCAAGGGGG CAGACCACAC 
AGACCTCCCC AGGGACAGCC TCCCCAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006240.4
CDS	39..968
Translation	MLLILLSVALLALSSAQSLNEDVSQEESPSVISGKPEGRRPQGGNQPQRTPPPPGKPEGRPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPRPGKPEGQPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPHPGKPEGPPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPRPGKPEGPPSQGGNKPQGPPPHPGKPQGPPPQEGNKPQRPPPPGRPQGPPPPGGNPQQPLPPPAGKPQGPPPPPQGGRPHRPPQGQPPQ

Target ORF information:

RefSeq Version	NM_006249.5
Organism	Homo sapiens(human)
Definition	Homo sapiens proline rich protein BstNI subfamily 3 (PRB3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006249.5

ORF Insert Sequence:

ATGCTACTGA TTCTGCTGTC GGTGGCCCTG CTGGCCCTGA GCTCAGCTCA GAGCTTAAAT 
GAAGATGTCA GCCAGGAAGA ATCTCCCTCC GTAATATCAG GAAAGCCAGA AGGACGACGC 
CCACAAGGAG GAAACCAGCC CCAACGTACC CCACCTCCTC CAGGAAAGCC AGAAGGACGA 
CCCCCACAAG GAGGCAACCA GTCCCAAGGT CCCCCACCTC GTCCAGGAAA GCCAGAAGGA 
CCACCCCCAC AAGGAGGAAA CCAGTCCCAA GGTCCCCCAC CTCGTCCGGG AAAGCCAGAA 
GGACAACCCC CACAAGGAGG AAACCAGTCC CAAGGTCCCC CACCTCGTCC GGGAAAGCCA 
GAAGGACCAC CCCCACAAGG AGGAAACCAG TCCCAAGGTC CCCCGCCTCG TCCGGGAAAG 
CCAGAAGGAC CACCCCCACA AGGAGGAAAC CAGTCCCAAG GTCCCCCGCC TCGTCCGGGA 
AAGCCAGAAG GACCACCCCC ACAAGGAGGA AACCAGTCCC AAGGTCCCCC GCCTCATCCG 
GGAAAGCCAG AAGGACCACC CCCACAAGGA GGAAACCAGT CCCAAGGTCC CCCACCTCGT 
CCGGGAAAGC CAGAAGGACC ACCCCCACAA GGAGGAAACC AGTCCCAAGG TCCCCCACCT 
CGTCCAGGAA AGCCAGAAGG ACCACCTTCA CAAGGAGGCA ACAAACCTCA AGGTCCCCCA 
CCTCATCCAG GAAAGCCACA AGGACCACCC CCACAAGAAG GTAACAAACC TCAACGTCCC 
CCTCCTCCAG GAAGGCCACA AGGACCACCC CCACCAGGAG GCAATCCCCA GCAGCCTCTG 
CCACCTCCCG CTGGAAAGCC CCAGGGACCA CCTCCACCTC CTCAAGGGGG CAGACCACAC 
AGACCTCCCC AGGGACAGCC TCCCCAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The intriguing heterogeneity of human salivary proline-rich proteins: Short title: Salivary proline-rich protein species.
Journal of proteomics13447-56(2016 Feb)
Manconi B,Castagnola M,Cabras T,Olianas A,Vitali A,Desiderio C,Sanna MT,Messana I

Low levels of PRB3 mRNA are associated with dopamine-agonist resistance and tumor recurrence in prolactinomas.
Journal of neuro-oncology116(1)83-8(2014 Jan)
Wang F,Gao H,Li C,Bai J,Lu R,Cao L,Wu Y,Hong L,Wu Y,Lan X,Zhang Y

Finding new posttranslational modifications in salivary proline-rich proteins.
Proteomics10(20)3732-42(2010 Oct)
Vitorino R,Alves R,Barros A,Caseiro A,Ferreira R,Lobo MC,Bastos A,Duarte J,Carvalho D,Santos LL,Amado FL

Identification of Lys-Pro-Gln as a novel cleavage site specificity of saliva-associated proteases.
The Journal of biological chemistry283(29)19957-66(2008 Jul)
Helmerhorst EJ,Sun X,Salih E,Oppenheim FG

PRB3 null mutations result in absence of the proline-rich glycoprotein Gl and abolish Fusobacterium nucleatum interactions with saliva in vitro.
Infection and immunity61(10)4434-9(1993 Oct)
Azen E,Prakobphol A,Fisher SJ

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PRB3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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