MCM10 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MCM10
Entrez Gene ID	55388
Full Name	minichromosome maintenance 10 replication initiation factor
Synonyms	CNA43,DNA43,PRO2249
General protein information	Preferred Names minichromosome maintenance 10 replication initiation factor Names protein MCM10 homolog MCM10 minichromosome maintenance deficient 10 homolog of yeast MCM10 hsMCM10 minichromosome maintenance complex component 10
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10p13
Summary	The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008].
Disorder MIM:	609357

mRNA and Protein(s)

mRNA	Protein	Name
NM_018518.4	NP_060988.3	protein MCM10 homolog isoform 2
XM_011519538.1	XP_011517840.1	protein MCM10 homolog isoform X1
NM_182751.3	NP_877428.1	protein MCM10 homolog isoform 1
NM_182751.2	NP_877428.1	protein MCM10 homolog isoform 1
XM_011519538.2	XP_011517840.1	protein MCM10 homolog isoform X1
NM_018518.5	NP_060988.3	protein MCM10 homolog isoform 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	MCM10	NP_877428.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008723	XP_314834.4
Pan troglodytes (chimpanzee)	MCM10	XP_001140870.1
	MCM10	XP_001085751.2
Xenopus tropicalis (tropical clawed frog)	mcm10	NP_001016909.1
Canis lupus familiaris (dog)	MCM10	XP_544256.1
Mus musculus (house mouse)	Mcm10	NP_081566.2
Gallus gallus (chicken)	MCM10	XP_004937544.1
Danio rerio (zebrafish)	mcm10	NP_001019984.1
Drosophila melanogaster (fruit fly)	Mcm10	NP_610097.2
Bos taurus (cattle)	MCM10	XP_005214368.1
Rattus norvegicus (Norway rat)	Mcm10	NP_001100836.1

Gene Ontology
Bibliography

Related articles in PubMed

The Mcm2-7-interacting domain of human mini-chromosome maintenance 10 (Mcm10) protein is important for stable chromatin association and origin firing.
Izumi M, Mizuno T, Yanagi KI, Sugimura K, Okumura K, Imamoto N, Abe T, Hanaoka F
The Journal of biological chemistry292(31)13008-13021(2017 08)

MCM10 overexpression implicates adverse prognosis in urothelial carcinoma.
Li WM, Huang CN, Ke HL, Li CC, Wei YC, Yeh HC, Chang LL, Huang CH, Liang PI, Yeh BW, Chan TC, Li CF, Wu WJ
Oncotarget7(47)77777-77792(2016 Nov)

HIV-1 Vpr Protein Enhances Proteasomal Degradation of MCM10 DNA Replication Factor through the Cul4-DDB1[VprBP] E3 Ubiquitin Ligase to Induce G2/M Cell Cycle Arrest.
Romani B, Shaykh Baygloo N, Aghasadeghi MR, Allahbakhshi E
The Journal of biological chemistry290(28)17380-9(2015 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that interaction of Mcm10 with Mcm2-7 multimer requires Mcm10 domain that contains amino acids 530-655, which overlaps with domain required for stable retention of Mcm10 on chromatin; Mcm10 conserved domain (amino acids 200-482) is essential for DNA replication; both conserved domain and Mcm2-7-binding domain are required for full activity of Mcm10.
Title: The Mcm2-7-interacting domain of human mini-chromosome maintenance 10 (Mcm10) protein is important for stable chromatin association and origin firing.

MCM10 is the natural substrate of the Cul4-DDB1[VprBP] E3 ubiquitin ligase whose degradation is regulated by VprBP, but Vpr enhances the proteasomal degradation of MCM10 by interacting with VprBP.
Title: HIV-1 Vpr Protein Enhances Proteasomal Degradation of MCM10 DNA Replication Factor through the Cul4-DDB1[VprBP] E3 Ubiquitin Ligase to Induce G2/M Cell Cycle Arrest.

RecQL4-dependent association of Mcm10 and Ctf4 with replication origins appears to be the first important step controlled by S phase promoting kinases and checkpoint pathways for the initiation of DNA replication in human cells.
Title: RecQL4 is required for the association of Mcm10 and Ctf4 with replication origins in human cells.

Loss of Mcm10 engages checkpoint, DNA repair and SUMO-dependent rescue pathways that collectively counteract replication stress and chromosome breakage. [Review]
Title: MCM10: one tool for all-Integrity, maintenance and damage control.

Data suggest that CDC45 and MCM10 (minichromosome maintenance complex component 10) directly interact and establish a mutual co-operation in DNA binding; key domains appear to interact and then interact with DNA inside cells or in cell-free systems.
Title: The physical interaction of Mcm10 with Cdc45 modulates their DNA-binding properties.

The following MCM10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MCM10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09381	NM_182751.3 Latest version!	Homo sapiens minichromosome maintenance 10 replication initiation factor (MCM10), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu09381	XM_011519538.2 Latest version!	Homo sapiens minichromosome maintenance 10 replication initiation factor (MCM10), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu09401	NM_018518.5 Latest version!	Homo sapiens minichromosome maintenance 10 replication initiation factor (MCM10), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$265.30 $379.00
View Old Accession Versions >>
OHu09381	NM_182751.2	Homo sapiens minichromosome maintenance 10 replication initiation factor (MCM10), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu09381	XM_011519538.1	Homo sapiens minichromosome maintenance complex component 10 (MCM10), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu09401	NM_018518.4	Homo sapiens minichromosome maintenance 10 replication initiation factor (MCM10), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MCM10 ( NM_182751.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_877428.1 Homo sapiens minichromosome maintenance 10 replication initiation factor (MCM10), transcript variant 1, mRNA.

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CloneID	OHu09381
Clone ID Related Accession (Same CDS sequence)	XM_011519538.1 , NM_182751.3 , NM_182751.2 , XM_011519538.2
Accession Version	NM_182751.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2628bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	protein MCM10 homolog isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA024424.1, AK055695.1, AB042719.1, AL136840.1 and AL138764.21. On Jun 2, 2019 this sequence version replaced NM_182751.2. Transcript Variant: This variant (1) uses a different splice site, compared to variant 2, that results in a longer isoform (1). Though this variant is supported by EST data, the existence of its encoded isoform has not been experimentally verified. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK292701.1, BC101727.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATGAGG AGGAAGACAA TCTGTCTCTG CTGACCGCAC TGCTGGAAGA AAATGAGTCA 
GCCTTGGATT GTAATTCAGA AGAAAATAAC TTCTTGACGC GGGAAAATGG CGAGCCCGAC 
GCATTTGATG AGCTCTTTGA TGCCGACGGC GACGGTGAAT CTTATACAGA AGAGGCTGAT 
GATGGAGAAA CAGGAGAGAC AAGAGACGAA AAGGAAAATC TGGCCACTCT CTTTGGAGAT 
ATGGAGGACT TAACAGATGA AGAAGAAGTT CCCGCATCAC AGTCAACTGA AAATAGGGTC 
CTCCCTGCTC CTGCCCCCAG GCGAGAGAAA ACGAATGAAG AGTTGCAAGA GGAATTAAGG 
AATTTGCAAG AGCAAATGAA GGCCTTACAA GAGCAGCTAA AAGTAACAAC AATTAAACAG 
ACAGCAAGCC CAGCCCGTCT GCAAAAATCC CCTGTAGAGA AGTCTCCCCG GCCACCTCTT 
AAGGAGAGGA GAGTTCAGAG AATTCAGGAG TCAACATGCT TTTCTGCGGA GCTTGATGTC 
CCTGCGCTAC CAAGAACCAA GAGGGTGGCT CGAACACCAA AGGCTTCACC TCCAGATCCC 
AAAAGCTCAT CTTCAAGGAT GACAAGTGCA CCCTCCCAAC CCCTACAGAC GATTTCTCGG 
AACAAACCTA GTGGGATAAC TAGAGGTCAA ATTGTGGGGA CCCCAGGAAG TTCTGGGGAA 
ACGACTCAAC CCATCTGTGT GGAAGCCTTC TCTGGTCTGC GGCTCAGGCG GCCTCGAGTA 
TCCTCCACAG AAATGAACAA GAAAATGACC GGCCGAAAAC TGATCAGACT GTCTCAGATC 
AAGGAAAAGA TGGCCAGAGA GAAGCTGGAA GAAATAGATT GGGTGACATT TGGGGTTATA 
TTGAAGAAGG TTACGCCACA GAGTGTGAAT AGTGGAAAAA CCTTCAGCAT ATGGAAACTG 
AATGATCTTC GTGACCTGAC ACAATGTGTG TCCTTGTTCT TATTTGGAGA AGTTCACAAA 
GCGCTCTGGA AGACGGAGCA GGGGACTGTC GTAGGGATCC TCAATGCCAA CCCCATGAAG 
CCCAAGGATG GTTCAGAGGA GGTGTGTTTA TCTATCGATC ATCCTCAGAA GGTCTTAATT 
ATGGGTGAAG CTCTTGACCT GGGAACCTGT AAAGCCAAGA AGAAGAATGG AGAGCCGTGC 
ACGCAGACTG TGAATTTGCG TGACTGTGAG TACTGTCAGT ACCATGTCCA GGCTCAGTAC 
AAGAAGCTCA GCGCAAAGCG TGCGGATCTG CAGTCCACCT TCTCTGGAGG ACGAATTCCA 
AAGAAGTTTG CCCGCAGAGG CACCAGCCTC AAAGAACGGC TGTGCCAAGA TGGCTTTTAC 
TACGGAGGGG TTTCTTCTGC CTCGTATGCA GCTTCAATTG CAGCAGCTGT GGCTCCTAAG 
AAGAAGATTC AAACCACTCT GAGTAATCTG GTTGTTAAGG GCACAAACTT GATCATCCAG 
GAAACACGGC AAAAACTCGG AATACCCCAG AAGAGCCTGT CTTGCTCTGA GGAGTTCAAG 
GAACTGATGG ACCTGCCGAC GTGTGGAGCC AGGAACTTAA AACAACATTT AGCCAAAGCC 
ACAGCTTCAG GGATTATGGG GAGCCCAAAA CCAGCCATCA AGTCCATCTC GGCCTCAGCA 
CTCTTGAAGC AACAGAAGCA GCGGATGTTG GAGATGAGGA GAAGGAAATC AGAAGAAATA 
CAGAAGCGAT TTCTGCAGAG CTCAAGTGAA GTTGAGAGCC CAGCTGTGCC ATCTTCATCA 
AGACAGCCCC CTGCTCAGCC TCCACGGACA GGATCCGAGT TCCCCAGGCT GGAGGGAGCC 
CCGGCCACAA TGACGCCCAA GCTGGGGCGA GGTGTCTTGG AAGGAGATGA TGTTCTCTTT 
TATGATGAGT CACCACCACC AAGACCAAAA CTGAGTGCTT TAGCAGAAGC CAAAAAGTTA 
GCTGCTATCA CCAAATTAAG GGCAAAAGGC CAGGTTCTTA CAAAAACAAA CCCAAACAGC 
ATTAAGAAGA AACAAAAGGA CCCTCAGGAC ATCCTGGAGG TGAAGGAACG TGTAGAAAAA 
AACACCATGT TTTCTTCTCA AGCTGAGGAT GAATTGGAGC CTGCCAGGAA AAAAAGGAGA 
GAACAACTTG CCTATCTGGA ATCTGAGGAA TTTCAGAAAA TCCTAAAAGC AAAATCAAAA 
CACACAGGCA TCCTGAAAGA GGCCGAGGCT GAGATGCAGG AGCGCTACTT TGAGCCACTG 
GTGAAAAAAG AACAAATGGA AGAAAAGATG AGAAACATCA GAGAAGTGAA GTGCCGTGTC 
GTGACATGCA AGACGTGCGC CTATACCCAC TTCAAGCTGC TGGAGACCTG CGTCAGTGAG 
CAGCATGAAT ACCACTGGCA TGATGGTGTG AAGAGGTTTT TCAAATGTCC CTGTGGAAAC 
AGAAGCATCT CCTTGGACAG ACTCCCGAAC AAGCACTGCA GTAACTGTGG CCTCTACAAA 
TGGGAACGGG ACGGAATGCT AAAGGAAAAG ACTGGTCCAA AGATAGGAGG AGAAACTCTG 
TTACCAAGAG GAGAAGAACA TGCTAAATTT CTGAACAGCC TTAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_877428.1
CDS	125..2752
Translation	MDEEEDNLSLLTALLEENESALDCNSEENNFLTRENGEPDAFDELFDADGDGESYTEEADDGETGETRDEKENLATLFGDMEDLTDEEEVPASQSTENRVLPAPAPRREKTNEELQEELRNLQEQMKALQEQLKVTTIKQTASPARLQKSPVEKSPRPPLKERRVQRIQESTCFSAELDVPALPRTKRVARTPKASPPDPKSSSSRMTSAPSQPLQTISRNKPSGITRGQIVGTPGSSGETTQPICVEAFSGLRLRRPRVSSTEMNKKMTGRKLIRLSQIKEKMAREKLEEIDWVTFGVILKKVTPQSVNSGKTFSIWKLNDLRDLTQCVSLFLFGEVHKALWKTEQGTVVGILNANPMKPKDGSEEVCLSIDHPQKVLIMGEALDLGTCKAKKKNGEPCTQTVNLRDCEYCQYHVQAQYKKLSAKRADLQSTFSGGRIPKKFARRGTSLKERLCQDGFYYGGVSSASYAASIAAAVAPKKKIQTTLSNLVVKGTNLIIQETRQKLGIPQKSLSCSEEFKELMDLPTCGARNLKQHLAKATASGIMGSPKPAIKSISASALLKQQKQRMLEMRRRKSEEIQKRFLQSSSEVESPAVPSSSRQPPAQPPRTGSEFPRLEGAPATMTPKLGRGVLEGDDVLFYDESPPPRPKLSALAEAKKLAAITKLRAKGQVLTKTNPNSIKKKQKDPQDILEVKERVEKNTMFSSQAEDELEPARKKRREQLAYLESEEFQKILKAKSKHTGILKEAEAEMQERYFEPLVKKEQMEEKMRNIREVKCRVVTCKTCAYTHFKLLETCVSEQHEYHWHDGVKRFFKCPCGNRSISLDRLPNKHCSNCGLYKWERDGMLKEKTGPKIGGETLLPRGEEHAKFLNSLK

Target ORF information:

RefSeq Version	NM_182751.3
Organism	Homo sapiens(human)
Definition	Homo sapiens minichromosome maintenance 10 replication initiation factor (MCM10), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_182751.3

ORF Insert Sequence:

ATGGATGAGG AGGAAGACAA TCTGTCTCTG CTGACCGCAC TGCTGGAAGA AAATGAGTCA 
GCCTTGGATT GTAATTCAGA AGAAAATAAC TTCTTGACGC GGGAAAATGG CGAGCCCGAC 
GCATTTGATG AGCTCTTTGA TGCCGACGGC GACGGTGAAT CTTATACAGA AGAGGCTGAT 
GATGGAGAAA CAGGAGAGAC AAGAGACGAA AAGGAAAATC TGGCCACTCT CTTTGGAGAT 
ATGGAGGACT TAACAGATGA AGAAGAAGTT CCCGCATCAC AGTCAACTGA AAATAGGGTC 
CTCCCTGCTC CTGCCCCCAG GCGAGAGAAA ACGAATGAAG AGTTGCAAGA GGAATTAAGG 
AATTTGCAAG AGCAAATGAA GGCCTTACAA GAGCAGCTAA AAGTAACAAC AATTAAACAG 
ACAGCAAGCC CAGCCCGTCT GCAAAAATCC CCTGTAGAGA AGTCTCCCCG GCCACCTCTT 
AAGGAGAGGA GAGTTCAGAG AATTCAGGAG TCAACATGCT TTTCTGCGGA GCTTGATGTC 
CCTGCGCTAC CAAGAACCAA GAGGGTGGCT CGAACACCAA AGGCTTCACC TCCAGATCCC 
AAAAGCTCAT CTTCAAGGAT GACAAGTGCA CCCTCCCAAC CCCTACAGAC GATTTCTCGG 
AACAAACCTA GTGGGATAAC TAGAGGTCAA ATTGTGGGGA CCCCAGGAAG TTCTGGGGAA 
ACGACTCAAC CCATCTGTGT GGAAGCCTTC TCTGGTCTGC GGCTCAGGCG GCCTCGAGTA 
TCCTCCACAG AAATGAACAA GAAAATGACC GGCCGAAAAC TGATCAGACT GTCTCAGATC 
AAGGAAAAGA TGGCCAGAGA GAAGCTGGAA GAAATAGATT GGGTGACATT TGGGGTTATA 
TTGAAGAAGG TTACGCCACA GAGTGTGAAT AGTGGAAAAA CCTTCAGCAT ATGGAAACTG 
AATGATCTTC GTGACCTGAC ACAATGTGTG TCCTTGTTCT TATTTGGAGA AGTTCACAAA 
GCGCTCTGGA AGACGGAGCA GGGGACTGTC GTAGGGATCC TCAATGCCAA CCCCATGAAG 
CCCAAGGATG GTTCAGAGGA GGTGTGTTTA TCTATCGATC ATCCTCAGAA GGTCTTAATT 
ATGGGTGAAG CTCTTGACCT GGGAACCTGT AAAGCCAAGA AGAAGAATGG AGAGCCGTGC 
ACGCAGACTG TGAATTTGCG TGACTGTGAG TACTGTCAGT ACCATGTCCA GGCTCAGTAC 
AAGAAGCTCA GCGCAAAGCG TGCGGATCTG CAGTCCACCT TCTCTGGAGG ACGAATTCCA 
AAGAAGTTTG CCCGCAGAGG CACCAGCCTC AAAGAACGGC TGTGCCAAGA TGGCTTTTAC 
TACGGAGGGG TTTCTTCTGC CTCGTATGCA GCTTCAATTG CAGCAGCTGT GGCTCCTAAG 
AAGAAGATTC AAACCACTCT GAGTAATCTG GTTGTTAAGG GCACAAACTT GATCATCCAG 
GAAACACGGC AAAAACTCGG AATACCCCAG AAGAGCCTGT CTTGCTCTGA GGAGTTCAAG 
GAACTGATGG ACCTGCCGAC GTGTGGAGCC AGGAACTTAA AACAACATTT AGCCAAAGCC 
ACAGCTTCAG GGATTATGGG GAGCCCAAAA CCAGCCATCA AGTCCATCTC GGCCTCAGCA 
CTCTTGAAGC AACAGAAGCA GCGGATGTTG GAGATGAGGA GAAGGAAATC AGAAGAAATA 
CAGAAGCGAT TTCTGCAGAG CTCAAGTGAA GTTGAGAGCC CAGCTGTGCC ATCTTCATCA 
AGACAGCCCC CTGCTCAGCC TCCACGGACA GGATCCGAGT TCCCCAGGCT GGAGGGAGCC 
CCGGCCACAA TGACGCCCAA GCTGGGGCGA GGTGTCTTGG AAGGAGATGA TGTTCTCTTT 
TATGATGAGT CACCACCACC AAGACCAAAA CTGAGTGCTT TAGCAGAAGC CAAAAAGTTA 
GCTGCTATCA CCAAATTAAG GGCAAAAGGC CAGGTTCTTA CAAAAACAAA CCCAAACAGC 
ATTAAGAAGA AACAAAAGGA CCCTCAGGAC ATCCTGGAGG TGAAGGAACG TGTAGAAAAA 
AACACCATGT TTTCTTCTCA AGCTGAGGAT GAATTGGAGC CTGCCAGGAA AAAAAGGAGA 
GAACAACTTG CCTATCTGGA ATCTGAGGAA TTTCAGAAAA TCCTAAAAGC AAAATCAAAA 
CACACAGGCA TCCTGAAAGA GGCCGAGGCT GAGATGCAGG AGCGCTACTT TGAGCCACTG 
GTGAAAAAAG AACAAATGGA AGAAAAGATG AGAAACATCA GAGAAGTGAA GTGCCGTGTC 
GTGACATGCA AGACGTGCGC CTATACCCAC TTCAAGCTGC TGGAGACCTG CGTCAGTGAG 
CAGCATGAAT ACCACTGGCA TGATGGTGTG AAGAGGTTTT TCAAATGTCC CTGTGGAAAC 
AGAAGCATCT CCTTGGACAG ACTCCCGAAC AAGCACTGCA GTAACTGTGG CCTCTACAAA 
TGGGAACGGG ACGGAATGCT AAAGGAAAAG ACTGGTCCAA AGATAGGAGG AGAAACTCTG 
TTACCAAGAG GAGAAGAACA TGCTAAATTT CTGAACAGCC TTAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MCM10 ( NM_182751.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_877428.1 Homo sapiens minichromosome maintenance 10 replication initiation factor (MCM10), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu09381
Clone ID Related Accession (Same CDS sequence)	XM_011519538.1 , NM_182751.3 , NM_182751.2 , XM_011519538.2
Accession Version	NM_182751.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2628bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	protein MCM10 homolog isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA024424.1, AK055695.1, AB042719.1 and AL136840.1. On May 13, 2010 this sequence version replaced NM_182751.1. Transcript Variant: This variant (1) uses a different splice site, compared to variant 2, that results in a longer isoform (1). Though this variant is supported by EST data, the existence of its encoded isoform has not been experimentally verified. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK292701.1, BC101727.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATGAGG AGGAAGACAA TCTGTCTCTG CTGACCGCAC TGCTGGAAGA AAATGAGTCA 
GCCTTGGATT GTAATTCAGA AGAAAATAAC TTCTTGACGC GGGAAAATGG CGAGCCCGAC 
GCATTTGATG AGCTCTTTGA TGCCGACGGC GACGGTGAAT CTTATACAGA AGAGGCTGAT 
GATGGAGAAA CAGGAGAGAC AAGAGACGAA AAGGAAAATC TGGCCACTCT CTTTGGAGAT 
ATGGAGGACT TAACAGATGA AGAAGAAGTT CCCGCATCAC AGTCAACTGA AAATAGGGTC 
CTCCCTGCTC CTGCCCCCAG GCGAGAGAAA ACGAATGAAG AGTTGCAAGA GGAATTAAGG 
AATTTGCAAG AGCAAATGAA GGCCTTACAA GAGCAGCTAA AAGTAACAAC AATTAAACAG 
ACAGCAAGCC CAGCCCGTCT GCAAAAATCC CCTGTAGAGA AGTCTCCCCG GCCACCTCTT 
AAGGAGAGGA GAGTTCAGAG AATTCAGGAG TCAACATGCT TTTCTGCGGA GCTTGATGTC 
CCTGCGCTAC CAAGAACCAA GAGGGTGGCT CGAACACCAA AGGCTTCACC TCCAGATCCC 
AAAAGCTCAT CTTCAAGGAT GACAAGTGCA CCCTCCCAAC CCCTACAGAC GATTTCTCGG 
AACAAACCTA GTGGGATAAC TAGAGGTCAA ATTGTGGGGA CCCCAGGAAG TTCTGGGGAA 
ACGACTCAAC CCATCTGTGT GGAAGCCTTC TCTGGTCTGC GGCTCAGGCG GCCTCGAGTA 
TCCTCCACAG AAATGAACAA GAAAATGACC GGCCGAAAAC TGATCAGACT GTCTCAGATC 
AAGGAAAAGA TGGCCAGAGA GAAGCTGGAA GAAATAGATT GGGTGACATT TGGGGTTATA 
TTGAAGAAGG TTACGCCACA GAGTGTGAAT AGTGGAAAAA CCTTCAGCAT ATGGAAACTG 
AATGATCTTC GTGACCTGAC ACAATGTGTG TCCTTGTTCT TATTTGGAGA AGTTCACAAA 
GCGCTCTGGA AGACGGAGCA GGGGACTGTC GTAGGGATCC TCAATGCCAA CCCCATGAAG 
CCCAAGGATG GTTCAGAGGA GGTGTGTTTA TCTATCGATC ATCCTCAGAA GGTCTTAATT 
ATGGGTGAAG CTCTTGACCT GGGAACCTGT AAAGCCAAGA AGAAGAATGG AGAGCCGTGC 
ACGCAGACTG TGAATTTGCG TGACTGTGAG TACTGTCAGT ACCATGTCCA GGCTCAGTAC 
AAGAAGCTCA GCGCAAAGCG TGCGGATCTG CAGTCCACCT TCTCTGGAGG ACGAATTCCA 
AAGAAGTTTG CCCGCAGAGG CACCAGCCTC AAAGAACGGC TGTGCCAAGA TGGCTTTTAC 
TACGGAGGGG TTTCTTCTGC CTCGTATGCA GCTTCAATTG CAGCAGCTGT GGCTCCTAAG 
AAGAAGATTC AAACCACTCT GAGTAATCTG GTTGTTAAGG GCACAAACTT GATCATCCAG 
GAAACACGGC AAAAACTCGG AATACCCCAG AAGAGCCTGT CTTGCTCTGA GGAGTTCAAG 
GAACTGATGG ACCTGCCGAC GTGTGGAGCC AGGAACTTAA AACAACATTT AGCCAAAGCC 
ACAGCTTCAG GGATTATGGG GAGCCCAAAA CCAGCCATCA AGTCCATCTC GGCCTCAGCA 
CTCTTGAAGC AACAGAAGCA GCGGATGTTG GAGATGAGGA GAAGGAAATC AGAAGAAATA 
CAGAAGCGAT TTCTGCAGAG CTCAAGTGAA GTTGAGAGCC CAGCTGTGCC ATCTTCATCA 
AGACAGCCCC CTGCTCAGCC TCCACGGACA GGATCCGAGT TCCCCAGGCT GGAGGGAGCC 
CCGGCCACAA TGACGCCCAA GCTGGGGCGA GGTGTCTTGG AAGGAGATGA TGTTCTCTTT 
TATGATGAGT CACCACCACC AAGACCAAAA CTGAGTGCTT TAGCAGAAGC CAAAAAGTTA 
GCTGCTATCA CCAAATTAAG GGCAAAAGGC CAGGTTCTTA CAAAAACAAA CCCAAACAGC 
ATTAAGAAGA AACAAAAGGA CCCTCAGGAC ATCCTGGAGG TGAAGGAACG TGTAGAAAAA 
AACACCATGT TTTCTTCTCA AGCTGAGGAT GAATTGGAGC CTGCCAGGAA AAAAAGGAGA 
GAACAACTTG CCTATCTGGA ATCTGAGGAA TTTCAGAAAA TCCTAAAAGC AAAATCAAAA 
CACACAGGCA TCCTGAAAGA GGCCGAGGCT GAGATGCAGG AGCGCTACTT TGAGCCACTG 
GTGAAAAAAG AACAAATGGA AGAAAAGATG AGAAACATCA GAGAAGTGAA GTGCCGTGTC 
GTGACATGCA AGACGTGCGC CTATACCCAC TTCAAGCTGC TGGAGACCTG CGTCAGTGAG 
CAGCATGAAT ACCACTGGCA TGATGGTGTG AAGAGGTTTT TCAAATGTCC CTGTGGAAAC 
AGAAGCATCT CCTTGGACAG ACTCCCGAAC AAGCACTGCA GTAACTGTGG CCTCTACAAA 
TGGGAACGGG ACGGAATGCT AAAGGAAAAG ACTGGTCCAA AGATAGGAGG AGAAACTCTG 
TTACCAAGAG GAGAAGAACA TGCTAAATTT CTGAACAGCC TTAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_877428.1
CDS	129..2756
Translation	MDEEEDNLSLLTALLEENESALDCNSEENNFLTRENGEPDAFDELFDADGDGESYTEEADDGETGETRDEKENLATLFGDMEDLTDEEEVPASQSTENRVLPAPAPRREKTNEELQEELRNLQEQMKALQEQLKVTTIKQTASPARLQKSPVEKSPRPPLKERRVQRIQESTCFSAELDVPALPRTKRVARTPKASPPDPKSSSSRMTSAPSQPLQTISRNKPSGITRGQIVGTPGSSGETTQPICVEAFSGLRLRRPRVSSTEMNKKMTGRKLIRLSQIKEKMAREKLEEIDWVTFGVILKKVTPQSVNSGKTFSIWKLNDLRDLTQCVSLFLFGEVHKALWKTEQGTVVGILNANPMKPKDGSEEVCLSIDHPQKVLIMGEALDLGTCKAKKKNGEPCTQTVNLRDCEYCQYHVQAQYKKLSAKRADLQSTFSGGRIPKKFARRGTSLKERLCQDGFYYGGVSSASYAASIAAAVAPKKKIQTTLSNLVVKGTNLIIQETRQKLGIPQKSLSCSEEFKELMDLPTCGARNLKQHLAKATASGIMGSPKPAIKSISASALLKQQKQRMLEMRRRKSEEIQKRFLQSSSEVESPAVPSSSRQPPAQPPRTGSEFPRLEGAPATMTPKLGRGVLEGDDVLFYDESPPPRPKLSALAEAKKLAAITKLRAKGQVLTKTNPNSIKKKQKDPQDILEVKERVEKNTMFSSQAEDELEPARKKRREQLAYLESEEFQKILKAKSKHTGILKEAEAEMQERYFEPLVKKEQMEEKMRNIREVKCRVVTCKTCAYTHFKLLETCVSEQHEYHWHDGVKRFFKCPCGNRSISLDRLPNKHCSNCGLYKWERDGMLKEKTGPKIGGETLLPRGEEHAKFLNSLK

Target ORF information:

RefSeq Version	NM_182751.2
Organism	Homo sapiens(human)
Definition	Homo sapiens minichromosome maintenance 10 replication initiation factor (MCM10), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_182751.2

ORF Insert Sequence:

ATGGATGAGG AGGAAGACAA TCTGTCTCTG CTGACCGCAC TGCTGGAAGA AAATGAGTCA 
GCCTTGGATT GTAATTCAGA AGAAAATAAC TTCTTGACGC GGGAAAATGG CGAGCCCGAC 
GCATTTGATG AGCTCTTTGA TGCCGACGGC GACGGTGAAT CTTATACAGA AGAGGCTGAT 
GATGGAGAAA CAGGAGAGAC AAGAGACGAA AAGGAAAATC TGGCCACTCT CTTTGGAGAT 
ATGGAGGACT TAACAGATGA AGAAGAAGTT CCCGCATCAC AGTCAACTGA AAATAGGGTC 
CTCCCTGCTC CTGCCCCCAG GCGAGAGAAA ACGAATGAAG AGTTGCAAGA GGAATTAAGG 
AATTTGCAAG AGCAAATGAA GGCCTTACAA GAGCAGCTAA AAGTAACAAC AATTAAACAG 
ACAGCAAGCC CAGCCCGTCT GCAAAAATCC CCTGTAGAGA AGTCTCCCCG GCCACCTCTT 
AAGGAGAGGA GAGTTCAGAG AATTCAGGAG TCAACATGCT TTTCTGCGGA GCTTGATGTC 
CCTGCGCTAC CAAGAACCAA GAGGGTGGCT CGAACACCAA AGGCTTCACC TCCAGATCCC 
AAAAGCTCAT CTTCAAGGAT GACAAGTGCA CCCTCCCAAC CCCTACAGAC GATTTCTCGG 
AACAAACCTA GTGGGATAAC TAGAGGTCAA ATTGTGGGGA CCCCAGGAAG TTCTGGGGAA 
ACGACTCAAC CCATCTGTGT GGAAGCCTTC TCTGGTCTGC GGCTCAGGCG GCCTCGAGTA 
TCCTCCACAG AAATGAACAA GAAAATGACC GGCCGAAAAC TGATCAGACT GTCTCAGATC 
AAGGAAAAGA TGGCCAGAGA GAAGCTGGAA GAAATAGATT GGGTGACATT TGGGGTTATA 
TTGAAGAAGG TTACGCCACA GAGTGTGAAT AGTGGAAAAA CCTTCAGCAT ATGGAAACTG 
AATGATCTTC GTGACCTGAC ACAATGTGTG TCCTTGTTCT TATTTGGAGA AGTTCACAAA 
GCGCTCTGGA AGACGGAGCA GGGGACTGTC GTAGGGATCC TCAATGCCAA CCCCATGAAG 
CCCAAGGATG GTTCAGAGGA GGTGTGTTTA TCTATCGATC ATCCTCAGAA GGTCTTAATT 
ATGGGTGAAG CTCTTGACCT GGGAACCTGT AAAGCCAAGA AGAAGAATGG AGAGCCGTGC 
ACGCAGACTG TGAATTTGCG TGACTGTGAG TACTGTCAGT ACCATGTCCA GGCTCAGTAC 
AAGAAGCTCA GCGCAAAGCG TGCGGATCTG CAGTCCACCT TCTCTGGAGG ACGAATTCCA 
AAGAAGTTTG CCCGCAGAGG CACCAGCCTC AAAGAACGGC TGTGCCAAGA TGGCTTTTAC 
TACGGAGGGG TTTCTTCTGC CTCGTATGCA GCTTCAATTG CAGCAGCTGT GGCTCCTAAG 
AAGAAGATTC AAACCACTCT GAGTAATCTG GTTGTTAAGG GCACAAACTT GATCATCCAG 
GAAACACGGC AAAAACTCGG AATACCCCAG AAGAGCCTGT CTTGCTCTGA GGAGTTCAAG 
GAACTGATGG ACCTGCCGAC GTGTGGAGCC AGGAACTTAA AACAACATTT AGCCAAAGCC 
ACAGCTTCAG GGATTATGGG GAGCCCAAAA CCAGCCATCA AGTCCATCTC GGCCTCAGCA 
CTCTTGAAGC AACAGAAGCA GCGGATGTTG GAGATGAGGA GAAGGAAATC AGAAGAAATA 
CAGAAGCGAT TTCTGCAGAG CTCAAGTGAA GTTGAGAGCC CAGCTGTGCC ATCTTCATCA 
AGACAGCCCC CTGCTCAGCC TCCACGGACA GGATCCGAGT TCCCCAGGCT GGAGGGAGCC 
CCGGCCACAA TGACGCCCAA GCTGGGGCGA GGTGTCTTGG AAGGAGATGA TGTTCTCTTT 
TATGATGAGT CACCACCACC AAGACCAAAA CTGAGTGCTT TAGCAGAAGC CAAAAAGTTA 
GCTGCTATCA CCAAATTAAG GGCAAAAGGC CAGGTTCTTA CAAAAACAAA CCCAAACAGC 
ATTAAGAAGA AACAAAAGGA CCCTCAGGAC ATCCTGGAGG TGAAGGAACG TGTAGAAAAA 
AACACCATGT TTTCTTCTCA AGCTGAGGAT GAATTGGAGC CTGCCAGGAA AAAAAGGAGA 
GAACAACTTG CCTATCTGGA ATCTGAGGAA TTTCAGAAAA TCCTAAAAGC AAAATCAAAA 
CACACAGGCA TCCTGAAAGA GGCCGAGGCT GAGATGCAGG AGCGCTACTT TGAGCCACTG 
GTGAAAAAAG AACAAATGGA AGAAAAGATG AGAAACATCA GAGAAGTGAA GTGCCGTGTC 
GTGACATGCA AGACGTGCGC CTATACCCAC TTCAAGCTGC TGGAGACCTG CGTCAGTGAG 
CAGCATGAAT ACCACTGGCA TGATGGTGTG AAGAGGTTTT TCAAATGTCC CTGTGGAAAC 
AGAAGCATCT CCTTGGACAG ACTCCCGAAC AAGCACTGCA GTAACTGTGG CCTCTACAAA 
TGGGAACGGG ACGGAATGCT AAAGGAAAAG ACTGGTCCAA AGATAGGAGG AGAAACTCTG 
TTACCAAGAG GAGAAGAACA TGCTAAATTT CTGAACAGCC TTAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MCM10 ( XM_011519538.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011517840.1 Homo sapiens minichromosome maintenance complex component 10 (MCM10), transcript variant X1, mRNA.

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CloneID	OHu09381
Clone ID Related Accession (Same CDS sequence)	XM_011519538.1 , NM_182751.3 , NM_182751.2 , XM_011519538.2
Accession Version	XM_011519538.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2628bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	protein MCM10 homolog isoform X1
Comment

ATGGATGAGG AGGAAGACAA TCTGTCTCTG CTGACCGCAC TGCTGGAAGA AAATGAGTCA 
GCCTTGGATT GTAATTCAGA AGAAAATAAC TTCTTGACGC GGGAAAATGG CGAGCCCGAC 
GCATTTGATG AGCTCTTTGA TGCCGACGGC GACGGTGAAT CTTATACAGA AGAGGCTGAT 
GATGGAGAAA CAGGAGAGAC AAGAGACGAA AAGGAAAATC TGGCCACTCT CTTTGGAGAT 
ATGGAGGACT TAACAGATGA AGAAGAAGTT CCCGCATCAC AGTCAACTGA AAATAGGGTC 
CTCCCTGCTC CTGCCCCCAG GCGAGAGAAA ACGAATGAAG AGTTGCAAGA GGAATTAAGG 
AATTTGCAAG AGCAAATGAA GGCCTTACAA GAGCAGCTAA AAGTAACAAC AATTAAACAG 
ACAGCAAGCC CAGCCCGTCT GCAAAAATCC CCTGTAGAGA AGTCTCCCCG GCCACCTCTT 
AAGGAGAGGA GAGTTCAGAG AATTCAGGAG TCAACATGCT TTTCTGCGGA GCTTGATGTC 
CCTGCGCTAC CAAGAACCAA GAGGGTGGCT CGAACACCAA AGGCTTCACC TCCAGATCCC 
AAAAGCTCAT CTTCAAGGAT GACAAGTGCA CCCTCCCAAC CCCTACAGAC GATTTCTCGG 
AACAAACCTA GTGGGATAAC TAGAGGTCAA ATTGTGGGGA CCCCAGGAAG TTCTGGGGAA 
ACGACTCAAC CCATCTGTGT GGAAGCCTTC TCTGGTCTGC GGCTCAGGCG GCCTCGAGTA 
TCCTCCACAG AAATGAACAA GAAAATGACC GGCCGAAAAC TGATCAGACT GTCTCAGATC 
AAGGAAAAGA TGGCCAGAGA GAAGCTGGAA GAAATAGATT GGGTGACATT TGGGGTTATA 
TTGAAGAAGG TTACGCCACA GAGTGTGAAT AGTGGAAAAA CCTTCAGCAT ATGGAAACTG 
AATGATCTTC GTGACCTGAC ACAATGTGTG TCCTTGTTCT TATTTGGAGA AGTTCACAAA 
GCGCTCTGGA AGACGGAGCA GGGGACTGTC GTAGGGATCC TCAATGCCAA CCCCATGAAG 
CCCAAGGATG GTTCAGAGGA GGTGTGTTTA TCTATCGATC ATCCTCAGAA GGTCTTAATT 
ATGGGTGAAG CTCTTGACCT GGGAACCTGT AAAGCCAAGA AGAAGAATGG AGAGCCGTGC 
ACGCAGACTG TGAATTTGCG TGACTGTGAG TACTGTCAGT ACCATGTCCA GGCTCAGTAC 
AAGAAGCTCA GCGCAAAGCG TGCGGATCTG CAGTCCACCT TCTCTGGAGG ACGAATTCCA 
AAGAAGTTTG CCCGCAGAGG CACCAGCCTC AAAGAACGGC TGTGCCAAGA TGGCTTTTAC 
TACGGAGGGG TTTCTTCTGC CTCGTATGCA GCTTCAATTG CAGCAGCTGT GGCTCCTAAG 
AAGAAGATTC AAACCACTCT GAGTAATCTG GTTGTTAAGG GCACAAACTT GATCATCCAG 
GAAACACGGC AAAAACTCGG AATACCCCAG AAGAGCCTGT CTTGCTCTGA GGAGTTCAAG 
GAACTGATGG ACCTGCCGAC GTGTGGAGCC AGGAACTTAA AACAACATTT AGCCAAAGCC 
ACAGCTTCAG GGATTATGGG GAGCCCAAAA CCAGCCATCA AGTCCATCTC GGCCTCAGCA 
CTCTTGAAGC AACAGAAGCA GCGGATGTTG GAGATGAGGA GAAGGAAATC AGAAGAAATA 
CAGAAGCGAT TTCTGCAGAG CTCAAGTGAA GTTGAGAGCC CAGCTGTGCC ATCTTCATCA 
AGACAGCCCC CTGCTCAGCC TCCACGGACA GGATCCGAGT TCCCCAGGCT GGAGGGAGCC 
CCGGCCACAA TGACGCCCAA GCTGGGGCGA GGTGTCTTGG AAGGAGATGA TGTTCTCTTT 
TATGATGAGT CACCACCACC AAGACCAAAA CTGAGTGCTT TAGCAGAAGC CAAAAAGTTA 
GCTGCTATCA CCAAATTAAG GGCAAAAGGC CAGGTTCTTA CAAAAACAAA CCCAAACAGC 
ATTAAGAAGA AACAAAAGGA CCCTCAGGAC ATCCTGGAGG TGAAGGAACG TGTAGAAAAA 
AACACCATGT TTTCTTCTCA AGCTGAGGAT GAATTGGAGC CTGCCAGGAA AAAAAGGAGA 
GAACAACTTG CCTATCTGGA ATCTGAGGAA TTTCAGAAAA TCCTAAAAGC AAAATCAAAA 
CACACAGGCA TCCTGAAAGA GGCCGAGGCT GAGATGCAGG AGCGCTACTT TGAGCCACTG 
GTGAAAAAAG AACAAATGGA AGAAAAGATG AGAAACATCA GAGAAGTGAA GTGCCGTGTC 
GTGACATGCA AGACGTGCGC CTATACCCAC TTCAAGCTGC TGGAGACCTG CGTCAGTGAG 
CAGCATGAAT ACCACTGGCA TGATGGTGTG AAGAGGTTTT TCAAATGTCC CTGTGGAAAC 
AGAAGCATCT CCTTGGACAG ACTCCCGAAC AAGCACTGCA GTAACTGTGG CCTCTACAAA 
TGGGAACGGG ACGGAATGCT AAAGGAAAAG ACTGGTCCAA AGATAGGAGG AGAAACTCTG 
TTACCAAGAG GAGAAGAACA TGCTAAATTT CTGAACAGCC TTAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

XP_011517840.1

Translation

MDEEEDNLSLLTALLEENESALDCNSEENNFLTRENGEPDAFDELFDADGDGESYTEEADDGETGETRDEKENLATLFGDMEDLTDEEEVPASQSTENRVLPAPAPRREKTNEELQEELRNLQEQMKALQEQLKVTTIKQTASPARLQKSPVEKSPRPPLKERRVQRIQESTCFSAELDVPALPRTKRVARTPKASPPDPKSSSSRMTSAPSQPLQTISRNKPSGITRGQIVGTPGSSGETTQPICVEAFSGLRLRRPRVSSTEMNKKMTGRKLIRLSQIKEKMAREKLEEIDWVTFGVILKKVTPQSVNSGKTFSIWKLNDLRDLTQCVSLFLFGEVHKALWKTEQGTVVGILNANPMKPKDGSEEVCLSIDHPQKVLIMGEALDLGTCKAKKKNGEPCTQTVNLRDCEYCQYHVQAQYKKLSAKRADLQSTFSGGRIPKKFARRGTSLKERLCQDGFYYGGVSSASYAASIAAAVAPKKKIQTTLSNLVVKGTNLIIQETRQKLGIPQKSLSCSEEFKELMDLPTCGARNLKQHLAKATASGIMGSPKPAIKSISASALLKQQKQRMLEMRRRKSEEIQKRFLQSSSEVESPAVPSSSRQPPAQPPRTGSEFPRLEGAPATMTPKLGRGVLEGDDVLFYDESPPPRPKLSALAEAKKLAAITKLRAKGQVLTKTNPNSIKKKQKDPQDILEVKERVEKNTMFSSQAEDELEPARKKRREQLAYLESEEFQKILKAKSKHTGILKEAEAEMQERYFEPLVKKEQMEEKMRNIREVKCRVVTCKTCAYTHFKLLETCVSEQHEYHWHDGVKRFFKCPCGNRSISLDRLPNKHCSNCGLYKWERDGMLKEKTGPKIGGETLLPRGEEHAKFLNSLK

Target ORF information:

RefSeq Version	XM_011519538.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens minichromosome maintenance complex component 10 (MCM10), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011519538.1

ORF Insert Sequence:

ATGGATGAGG AGGAAGACAA TCTGTCTCTG CTGACCGCAC TGCTGGAAGA AAATGAGTCA 
GCCTTGGATT GTAATTCAGA AGAAAATAAC TTCTTGACGC GGGAAAATGG CGAGCCCGAC 
GCATTTGATG AGCTCTTTGA TGCCGACGGC GACGGTGAAT CTTATACAGA AGAGGCTGAT 
GATGGAGAAA CAGGAGAGAC AAGAGACGAA AAGGAAAATC TGGCCACTCT CTTTGGAGAT 
ATGGAGGACT TAACAGATGA AGAAGAAGTT CCCGCATCAC AGTCAACTGA AAATAGGGTC 
CTCCCTGCTC CTGCCCCCAG GCGAGAGAAA ACGAATGAAG AGTTGCAAGA GGAATTAAGG 
AATTTGCAAG AGCAAATGAA GGCCTTACAA GAGCAGCTAA AAGTAACAAC AATTAAACAG 
ACAGCAAGCC CAGCCCGTCT GCAAAAATCC CCTGTAGAGA AGTCTCCCCG GCCACCTCTT 
AAGGAGAGGA GAGTTCAGAG AATTCAGGAG TCAACATGCT TTTCTGCGGA GCTTGATGTC 
CCTGCGCTAC CAAGAACCAA GAGGGTGGCT CGAACACCAA AGGCTTCACC TCCAGATCCC 
AAAAGCTCAT CTTCAAGGAT GACAAGTGCA CCCTCCCAAC CCCTACAGAC GATTTCTCGG 
AACAAACCTA GTGGGATAAC TAGAGGTCAA ATTGTGGGGA CCCCAGGAAG TTCTGGGGAA 
ACGACTCAAC CCATCTGTGT GGAAGCCTTC TCTGGTCTGC GGCTCAGGCG GCCTCGAGTA 
TCCTCCACAG AAATGAACAA GAAAATGACC GGCCGAAAAC TGATCAGACT GTCTCAGATC 
AAGGAAAAGA TGGCCAGAGA GAAGCTGGAA GAAATAGATT GGGTGACATT TGGGGTTATA 
TTGAAGAAGG TTACGCCACA GAGTGTGAAT AGTGGAAAAA CCTTCAGCAT ATGGAAACTG 
AATGATCTTC GTGACCTGAC ACAATGTGTG TCCTTGTTCT TATTTGGAGA AGTTCACAAA 
GCGCTCTGGA AGACGGAGCA GGGGACTGTC GTAGGGATCC TCAATGCCAA CCCCATGAAG 
CCCAAGGATG GTTCAGAGGA GGTGTGTTTA TCTATCGATC ATCCTCAGAA GGTCTTAATT 
ATGGGTGAAG CTCTTGACCT GGGAACCTGT AAAGCCAAGA AGAAGAATGG AGAGCCGTGC 
ACGCAGACTG TGAATTTGCG TGACTGTGAG TACTGTCAGT ACCATGTCCA GGCTCAGTAC 
AAGAAGCTCA GCGCAAAGCG TGCGGATCTG CAGTCCACCT TCTCTGGAGG ACGAATTCCA 
AAGAAGTTTG CCCGCAGAGG CACCAGCCTC AAAGAACGGC TGTGCCAAGA TGGCTTTTAC 
TACGGAGGGG TTTCTTCTGC CTCGTATGCA GCTTCAATTG CAGCAGCTGT GGCTCCTAAG 
AAGAAGATTC AAACCACTCT GAGTAATCTG GTTGTTAAGG GCACAAACTT GATCATCCAG 
GAAACACGGC AAAAACTCGG AATACCCCAG AAGAGCCTGT CTTGCTCTGA GGAGTTCAAG 
GAACTGATGG ACCTGCCGAC GTGTGGAGCC AGGAACTTAA AACAACATTT AGCCAAAGCC 
ACAGCTTCAG GGATTATGGG GAGCCCAAAA CCAGCCATCA AGTCCATCTC GGCCTCAGCA 
CTCTTGAAGC AACAGAAGCA GCGGATGTTG GAGATGAGGA GAAGGAAATC AGAAGAAATA 
CAGAAGCGAT TTCTGCAGAG CTCAAGTGAA GTTGAGAGCC CAGCTGTGCC ATCTTCATCA 
AGACAGCCCC CTGCTCAGCC TCCACGGACA GGATCCGAGT TCCCCAGGCT GGAGGGAGCC 
CCGGCCACAA TGACGCCCAA GCTGGGGCGA GGTGTCTTGG AAGGAGATGA TGTTCTCTTT 
TATGATGAGT CACCACCACC AAGACCAAAA CTGAGTGCTT TAGCAGAAGC CAAAAAGTTA 
GCTGCTATCA CCAAATTAAG GGCAAAAGGC CAGGTTCTTA CAAAAACAAA CCCAAACAGC 
ATTAAGAAGA AACAAAAGGA CCCTCAGGAC ATCCTGGAGG TGAAGGAACG TGTAGAAAAA 
AACACCATGT TTTCTTCTCA AGCTGAGGAT GAATTGGAGC CTGCCAGGAA AAAAAGGAGA 
GAACAACTTG CCTATCTGGA ATCTGAGGAA TTTCAGAAAA TCCTAAAAGC AAAATCAAAA 
CACACAGGCA TCCTGAAAGA GGCCGAGGCT GAGATGCAGG AGCGCTACTT TGAGCCACTG 
GTGAAAAAAG AACAAATGGA AGAAAAGATG AGAAACATCA GAGAAGTGAA GTGCCGTGTC 
GTGACATGCA AGACGTGCGC CTATACCCAC TTCAAGCTGC TGGAGACCTG CGTCAGTGAG 
CAGCATGAAT ACCACTGGCA TGATGGTGTG AAGAGGTTTT TCAAATGTCC CTGTGGAAAC 
AGAAGCATCT CCTTGGACAG ACTCCCGAAC AAGCACTGCA GTAACTGTGG CCTCTACAAA 
TGGGAACGGG ACGGAATGCT AAAGGAAAAG ACTGGTCCAA AGATAGGAGG AGAAACTCTG 
TTACCAAGAG GAGAAGAACA TGCTAAATTT CTGAACAGCC TTAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MCM10 ( XM_011519538.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011517840.1 Homo sapiens minichromosome maintenance 10 replication initiation factor (MCM10), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu09381
Clone ID Related Accession (Same CDS sequence)	XM_011519538.1 , NM_182751.3 , NM_182751.2 , XM_011519538.2
Accession Version	XM_011519538.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2628bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	protein MCM10 homolog isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011519538.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATGAGG AGGAAGACAA TCTGTCTCTG CTGACCGCAC TGCTGGAAGA AAATGAGTCA 
GCCTTGGATT GTAATTCAGA AGAAAATAAC TTCTTGACGC GGGAAAATGG CGAGCCCGAC 
GCATTTGATG AGCTCTTTGA TGCCGACGGC GACGGTGAAT CTTATACAGA AGAGGCTGAT 
GATGGAGAAA CAGGAGAGAC AAGAGACGAA AAGGAAAATC TGGCCACTCT CTTTGGAGAT 
ATGGAGGACT TAACAGATGA AGAAGAAGTT CCCGCATCAC AGTCAACTGA AAATAGGGTC 
CTCCCTGCTC CTGCCCCCAG GCGAGAGAAA ACGAATGAAG AGTTGCAAGA GGAATTAAGG 
AATTTGCAAG AGCAAATGAA GGCCTTACAA GAGCAGCTAA AAGTAACAAC AATTAAACAG 
ACAGCAAGCC CAGCCCGTCT GCAAAAATCC CCTGTAGAGA AGTCTCCCCG GCCACCTCTT 
AAGGAGAGGA GAGTTCAGAG AATTCAGGAG TCAACATGCT TTTCTGCGGA GCTTGATGTC 
CCTGCGCTAC CAAGAACCAA GAGGGTGGCT CGAACACCAA AGGCTTCACC TCCAGATCCC 
AAAAGCTCAT CTTCAAGGAT GACAAGTGCA CCCTCCCAAC CCCTACAGAC GATTTCTCGG 
AACAAACCTA GTGGGATAAC TAGAGGTCAA ATTGTGGGGA CCCCAGGAAG TTCTGGGGAA 
ACGACTCAAC CCATCTGTGT GGAAGCCTTC TCTGGTCTGC GGCTCAGGCG GCCTCGAGTA 
TCCTCCACAG AAATGAACAA GAAAATGACC GGCCGAAAAC TGATCAGACT GTCTCAGATC 
AAGGAAAAGA TGGCCAGAGA GAAGCTGGAA GAAATAGATT GGGTGACATT TGGGGTTATA 
TTGAAGAAGG TTACGCCACA GAGTGTGAAT AGTGGAAAAA CCTTCAGCAT ATGGAAACTG 
AATGATCTTC GTGACCTGAC ACAATGTGTG TCCTTGTTCT TATTTGGAGA AGTTCACAAA 
GCGCTCTGGA AGACGGAGCA GGGGACTGTC GTAGGGATCC TCAATGCCAA CCCCATGAAG 
CCCAAGGATG GTTCAGAGGA GGTGTGTTTA TCTATCGATC ATCCTCAGAA GGTCTTAATT 
ATGGGTGAAG CTCTTGACCT GGGAACCTGT AAAGCCAAGA AGAAGAATGG AGAGCCGTGC 
ACGCAGACTG TGAATTTGCG TGACTGTGAG TACTGTCAGT ACCATGTCCA GGCTCAGTAC 
AAGAAGCTCA GCGCAAAGCG TGCGGATCTG CAGTCCACCT TCTCTGGAGG ACGAATTCCA 
AAGAAGTTTG CCCGCAGAGG CACCAGCCTC AAAGAACGGC TGTGCCAAGA TGGCTTTTAC 
TACGGAGGGG TTTCTTCTGC CTCGTATGCA GCTTCAATTG CAGCAGCTGT GGCTCCTAAG 
AAGAAGATTC AAACCACTCT GAGTAATCTG GTTGTTAAGG GCACAAACTT GATCATCCAG 
GAAACACGGC AAAAACTCGG AATACCCCAG AAGAGCCTGT CTTGCTCTGA GGAGTTCAAG 
GAACTGATGG ACCTGCCGAC GTGTGGAGCC AGGAACTTAA AACAACATTT AGCCAAAGCC 
ACAGCTTCAG GGATTATGGG GAGCCCAAAA CCAGCCATCA AGTCCATCTC GGCCTCAGCA 
CTCTTGAAGC AACAGAAGCA GCGGATGTTG GAGATGAGGA GAAGGAAATC AGAAGAAATA 
CAGAAGCGAT TTCTGCAGAG CTCAAGTGAA GTTGAGAGCC CAGCTGTGCC ATCTTCATCA 
AGACAGCCCC CTGCTCAGCC TCCACGGACA GGATCCGAGT TCCCCAGGCT GGAGGGAGCC 
CCGGCCACAA TGACGCCCAA GCTGGGGCGA GGTGTCTTGG AAGGAGATGA TGTTCTCTTT 
TATGATGAGT CACCACCACC AAGACCAAAA CTGAGTGCTT TAGCAGAAGC CAAAAAGTTA 
GCTGCTATCA CCAAATTAAG GGCAAAAGGC CAGGTTCTTA CAAAAACAAA CCCAAACAGC 
ATTAAGAAGA AACAAAAGGA CCCTCAGGAC ATCCTGGAGG TGAAGGAACG TGTAGAAAAA 
AACACCATGT TTTCTTCTCA AGCTGAGGAT GAATTGGAGC CTGCCAGGAA AAAAAGGAGA 
GAACAACTTG CCTATCTGGA ATCTGAGGAA TTTCAGAAAA TCCTAAAAGC AAAATCAAAA 
CACACAGGCA TCCTGAAAGA GGCCGAGGCT GAGATGCAGG AGCGCTACTT TGAGCCACTG 
GTGAAAAAAG AACAAATGGA AGAAAAGATG AGAAACATCA GAGAAGTGAA GTGCCGTGTC 
GTGACATGCA AGACGTGCGC CTATACCCAC TTCAAGCTGC TGGAGACCTG CGTCAGTGAG 
CAGCATGAAT ACCACTGGCA TGATGGTGTG AAGAGGTTTT TCAAATGTCC CTGTGGAAAC 
AGAAGCATCT CCTTGGACAG ACTCCCGAAC AAGCACTGCA GTAACTGTGG CCTCTACAAA 
TGGGAACGGG ACGGAATGCT AAAGGAAAAG ACTGGTCCAA AGATAGGAGG AGAAACTCTG 
TTACCAAGAG GAGAAGAACA TGCTAAATTT CTGAACAGCC TTAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011517840.1
CDS	99..2726
Translation	MDEEEDNLSLLTALLEENESALDCNSEENNFLTRENGEPDAFDELFDADGDGESYTEEADDGETGETRDEKENLATLFGDMEDLTDEEEVPASQSTENRVLPAPAPRREKTNEELQEELRNLQEQMKALQEQLKVTTIKQTASPARLQKSPVEKSPRPPLKERRVQRIQESTCFSAELDVPALPRTKRVARTPKASPPDPKSSSSRMTSAPSQPLQTISRNKPSGITRGQIVGTPGSSGETTQPICVEAFSGLRLRRPRVSSTEMNKKMTGRKLIRLSQIKEKMAREKLEEIDWVTFGVILKKVTPQSVNSGKTFSIWKLNDLRDLTQCVSLFLFGEVHKALWKTEQGTVVGILNANPMKPKDGSEEVCLSIDHPQKVLIMGEALDLGTCKAKKKNGEPCTQTVNLRDCEYCQYHVQAQYKKLSAKRADLQSTFSGGRIPKKFARRGTSLKERLCQDGFYYGGVSSASYAASIAAAVAPKKKIQTTLSNLVVKGTNLIIQETRQKLGIPQKSLSCSEEFKELMDLPTCGARNLKQHLAKATASGIMGSPKPAIKSISASALLKQQKQRMLEMRRRKSEEIQKRFLQSSSEVESPAVPSSSRQPPAQPPRTGSEFPRLEGAPATMTPKLGRGVLEGDDVLFYDESPPPRPKLSALAEAKKLAAITKLRAKGQVLTKTNPNSIKKKQKDPQDILEVKERVEKNTMFSSQAEDELEPARKKRREQLAYLESEEFQKILKAKSKHTGILKEAEAEMQERYFEPLVKKEQMEEKMRNIREVKCRVVTCKTCAYTHFKLLETCVSEQHEYHWHDGVKRFFKCPCGNRSISLDRLPNKHCSNCGLYKWERDGMLKEKTGPKIGGETLLPRGEEHAKFLNSLK

Target ORF information:

RefSeq Version	XM_011519538.2
Organism	Homo sapiens(human)
Definition	Homo sapiens minichromosome maintenance 10 replication initiation factor (MCM10), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011519538.2

ORF Insert Sequence:

ATGGATGAGG AGGAAGACAA TCTGTCTCTG CTGACCGCAC TGCTGGAAGA AAATGAGTCA 
GCCTTGGATT GTAATTCAGA AGAAAATAAC TTCTTGACGC GGGAAAATGG CGAGCCCGAC 
GCATTTGATG AGCTCTTTGA TGCCGACGGC GACGGTGAAT CTTATACAGA AGAGGCTGAT 
GATGGAGAAA CAGGAGAGAC AAGAGACGAA AAGGAAAATC TGGCCACTCT CTTTGGAGAT 
ATGGAGGACT TAACAGATGA AGAAGAAGTT CCCGCATCAC AGTCAACTGA AAATAGGGTC 
CTCCCTGCTC CTGCCCCCAG GCGAGAGAAA ACGAATGAAG AGTTGCAAGA GGAATTAAGG 
AATTTGCAAG AGCAAATGAA GGCCTTACAA GAGCAGCTAA AAGTAACAAC AATTAAACAG 
ACAGCAAGCC CAGCCCGTCT GCAAAAATCC CCTGTAGAGA AGTCTCCCCG GCCACCTCTT 
AAGGAGAGGA GAGTTCAGAG AATTCAGGAG TCAACATGCT TTTCTGCGGA GCTTGATGTC 
CCTGCGCTAC CAAGAACCAA GAGGGTGGCT CGAACACCAA AGGCTTCACC TCCAGATCCC 
AAAAGCTCAT CTTCAAGGAT GACAAGTGCA CCCTCCCAAC CCCTACAGAC GATTTCTCGG 
AACAAACCTA GTGGGATAAC TAGAGGTCAA ATTGTGGGGA CCCCAGGAAG TTCTGGGGAA 
ACGACTCAAC CCATCTGTGT GGAAGCCTTC TCTGGTCTGC GGCTCAGGCG GCCTCGAGTA 
TCCTCCACAG AAATGAACAA GAAAATGACC GGCCGAAAAC TGATCAGACT GTCTCAGATC 
AAGGAAAAGA TGGCCAGAGA GAAGCTGGAA GAAATAGATT GGGTGACATT TGGGGTTATA 
TTGAAGAAGG TTACGCCACA GAGTGTGAAT AGTGGAAAAA CCTTCAGCAT ATGGAAACTG 
AATGATCTTC GTGACCTGAC ACAATGTGTG TCCTTGTTCT TATTTGGAGA AGTTCACAAA 
GCGCTCTGGA AGACGGAGCA GGGGACTGTC GTAGGGATCC TCAATGCCAA CCCCATGAAG 
CCCAAGGATG GTTCAGAGGA GGTGTGTTTA TCTATCGATC ATCCTCAGAA GGTCTTAATT 
ATGGGTGAAG CTCTTGACCT GGGAACCTGT AAAGCCAAGA AGAAGAATGG AGAGCCGTGC 
ACGCAGACTG TGAATTTGCG TGACTGTGAG TACTGTCAGT ACCATGTCCA GGCTCAGTAC 
AAGAAGCTCA GCGCAAAGCG TGCGGATCTG CAGTCCACCT TCTCTGGAGG ACGAATTCCA 
AAGAAGTTTG CCCGCAGAGG CACCAGCCTC AAAGAACGGC TGTGCCAAGA TGGCTTTTAC 
TACGGAGGGG TTTCTTCTGC CTCGTATGCA GCTTCAATTG CAGCAGCTGT GGCTCCTAAG 
AAGAAGATTC AAACCACTCT GAGTAATCTG GTTGTTAAGG GCACAAACTT GATCATCCAG 
GAAACACGGC AAAAACTCGG AATACCCCAG AAGAGCCTGT CTTGCTCTGA GGAGTTCAAG 
GAACTGATGG ACCTGCCGAC GTGTGGAGCC AGGAACTTAA AACAACATTT AGCCAAAGCC 
ACAGCTTCAG GGATTATGGG GAGCCCAAAA CCAGCCATCA AGTCCATCTC GGCCTCAGCA 
CTCTTGAAGC AACAGAAGCA GCGGATGTTG GAGATGAGGA GAAGGAAATC AGAAGAAATA 
CAGAAGCGAT TTCTGCAGAG CTCAAGTGAA GTTGAGAGCC CAGCTGTGCC ATCTTCATCA 
AGACAGCCCC CTGCTCAGCC TCCACGGACA GGATCCGAGT TCCCCAGGCT GGAGGGAGCC 
CCGGCCACAA TGACGCCCAA GCTGGGGCGA GGTGTCTTGG AAGGAGATGA TGTTCTCTTT 
TATGATGAGT CACCACCACC AAGACCAAAA CTGAGTGCTT TAGCAGAAGC CAAAAAGTTA 
GCTGCTATCA CCAAATTAAG GGCAAAAGGC CAGGTTCTTA CAAAAACAAA CCCAAACAGC 
ATTAAGAAGA AACAAAAGGA CCCTCAGGAC ATCCTGGAGG TGAAGGAACG TGTAGAAAAA 
AACACCATGT TTTCTTCTCA AGCTGAGGAT GAATTGGAGC CTGCCAGGAA AAAAAGGAGA 
GAACAACTTG CCTATCTGGA ATCTGAGGAA TTTCAGAAAA TCCTAAAAGC AAAATCAAAA 
CACACAGGCA TCCTGAAAGA GGCCGAGGCT GAGATGCAGG AGCGCTACTT TGAGCCACTG 
GTGAAAAAAG AACAAATGGA AGAAAAGATG AGAAACATCA GAGAAGTGAA GTGCCGTGTC 
GTGACATGCA AGACGTGCGC CTATACCCAC TTCAAGCTGC TGGAGACCTG CGTCAGTGAG 
CAGCATGAAT ACCACTGGCA TGATGGTGTG AAGAGGTTTT TCAAATGTCC CTGTGGAAAC 
AGAAGCATCT CCTTGGACAG ACTCCCGAAC AAGCACTGCA GTAACTGTGG CCTCTACAAA 
TGGGAACGGG ACGGAATGCT AAAGGAAAAG ACTGGTCCAA AGATAGGAGG AGAAACTCTG 
TTACCAAGAG GAGAAGAACA TGCTAAATTT CTGAACAGCC TTAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MCM10 ( NM_018518.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_060988.3 Homo sapiens minichromosome maintenance 10 replication initiation factor (MCM10), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu09401
Clone ID Related Accession (Same CDS sequence)	NM_018518.4 , NM_018518.5
Accession Version	NM_018518.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2625bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	protein MCM10 homolog isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA024424.1, AB042719.1 and AL136840.1. On May 13, 2010 this sequence version replaced NM_018518.3. Transcript Variant: This variant (2) encodes the predominant isoform (2). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB042719.1, BC143490.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATGAGG AGGAAGACAA TCTGTCTCTG CTGACCGCAC TGCTGGAAGA AAATGAGTCA 
GCCTTGGATT GTAATTCAGA AGAAAATAAC TTCTTGACGC GGGAAAATGG CGAGCCCGAC 
GCATTTGATG AGCTCTTTGA TGCCGACGGC GACGGTGAAT CTTATACAGA AGAGGCTGAT 
GATGGAGAAA CAGGAGAGAC AAGAGACGAA AAGGAAAATC TGGCCACTCT CTTTGGAGAT 
ATGGAGGACT TAACAGATGA AGAAGAAGTT CCCGCATCAC AGTCAACTGA AAATAGGGTC 
CTCCCTGCTC CTGCCCCCAG GCGAGAGAAA ACGAATGAAG AGTTGCAAGA GGAATTAAGG 
AATTTGCAAG AGCAAATGAA GGCCTTACAA GAGCAGCTAA AAGTAACAAC AATTAAACAG 
ACAGCAAGCC CAGCCCGTCT GCAAAAATCC CCTGAGAAGT CTCCCCGGCC ACCTCTTAAG 
GAGAGGAGAG TTCAGAGAAT TCAGGAGTCA ACATGCTTTT CTGCGGAGCT TGATGTCCCT 
GCGCTACCAA GAACCAAGAG GGTGGCTCGA ACACCAAAGG CTTCACCTCC AGATCCCAAA 
AGCTCATCTT CAAGGATGAC AAGTGCACCC TCCCAACCCC TACAGACGAT TTCTCGGAAC 
AAACCTAGTG GGATAACTAG AGGTCAAATT GTGGGGACCC CAGGAAGTTC TGGGGAAACG 
ACTCAACCCA TCTGTGTGGA AGCCTTCTCT GGTCTGCGGC TCAGGCGGCC TCGAGTATCC 
TCCACAGAAA TGAACAAGAA AATGACCGGC CGAAAACTGA TCAGACTGTC TCAGATCAAG 
GAAAAGATGG CCAGAGAGAA GCTGGAAGAA ATAGATTGGG TGACATTTGG GGTTATATTG 
AAGAAGGTTA CGCCACAGAG TGTGAATAGT GGAAAAACCT TCAGCATATG GAAACTGAAT 
GATCTTCGTG ACCTGACACA ATGTGTGTCC TTGTTCTTAT TTGGAGAAGT TCACAAAGCG 
CTCTGGAAGA CGGAGCAGGG GACTGTCGTA GGGATCCTCA ATGCCAACCC CATGAAGCCC 
AAGGATGGTT CAGAGGAGGT GTGTTTATCT ATCGATCATC CTCAGAAGGT CTTAATTATG 
GGTGAAGCTC TTGACCTGGG AACCTGTAAA GCCAAGAAGA AGAATGGAGA GCCGTGCACG 
CAGACTGTGA ATTTGCGTGA CTGTGAGTAC TGTCAGTACC ATGTCCAGGC TCAGTACAAG 
AAGCTCAGCG CAAAGCGTGC GGATCTGCAG TCCACCTTCT CTGGAGGACG AATTCCAAAG 
AAGTTTGCCC GCAGAGGCAC CAGCCTCAAA GAACGGCTGT GCCAAGATGG CTTTTACTAC 
GGAGGGGTTT CTTCTGCCTC GTATGCAGCT TCAATTGCAG CAGCTGTGGC TCCTAAGAAG 
AAGATTCAAA CCACTCTGAG TAATCTGGTT GTTAAGGGCA CAAACTTGAT CATCCAGGAA 
ACACGGCAAA AACTCGGAAT ACCCCAGAAG AGCCTGTCTT GCTCTGAGGA GTTCAAGGAA 
CTGATGGACC TGCCGACGTG TGGAGCCAGG AACTTAAAAC AACATTTAGC CAAAGCCACA 
GCTTCAGGGA TTATGGGGAG CCCAAAACCA GCCATCAAGT CCATCTCGGC CTCAGCACTC 
TTGAAGCAAC AGAAGCAGCG GATGTTGGAG ATGAGGAGAA GGAAATCAGA AGAAATACAG 
AAGCGATTTC TGCAGAGCTC AAGTGAAGTT GAGAGCCCAG CTGTGCCATC TTCATCAAGA 
CAGCCCCCTG CTCAGCCTCC ACGGACAGGA TCCGAGTTCC CCAGGCTGGA GGGAGCCCCG 
GCCACAATGA CGCCCAAGCT GGGGCGAGGT GTCTTGGAAG GAGATGATGT TCTCTTTTAT 
GATGAGTCAC CACCACCAAG ACCAAAACTG AGTGCTTTAG CAGAAGCCAA AAAGTTAGCT 
GCTATCACCA AATTAAGGGC AAAAGGCCAG GTTCTTACAA AAACAAACCC AAACAGCATT 
AAGAAGAAAC AAAAGGACCC TCAGGACATC CTGGAGGTGA AGGAACGTGT AGAAAAAAAC 
ACCATGTTTT CTTCTCAAGC TGAGGATGAA TTGGAGCCTG CCAGGAAAAA AAGGAGAGAA 
CAACTTGCCT ATCTGGAATC TGAGGAATTT CAGAAAATCC TAAAAGCAAA ATCAAAACAC 
ACAGGCATCC TGAAAGAGGC CGAGGCTGAG ATGCAGGAGC GCTACTTTGA GCCACTGGTG 
AAAAAAGAAC AAATGGAAGA AAAGATGAGA AACATCAGAG AAGTGAAGTG CCGTGTCGTG 
ACATGCAAGA CGTGCGCCTA TACCCACTTC AAGCTGCTGG AGACCTGCGT CAGTGAGCAG 
CATGAATACC ACTGGCATGA TGGTGTGAAG AGGTTTTTCA AATGTCCCTG TGGAAACAGA 
AGCATCTCCT TGGACAGACT CCCGAACAAG CACTGCAGTA ACTGTGGCCT CTACAAATGG 
GAACGGGACG GAATGCTAAA GGAAAAGACT GGTCCAAAGA TAGGAGGAGA AACTCTGTTA 
CCAAGAGGAG AAGAACATGC TAAATTTCTG AACAGCCTTA AATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060988.3
CDS	129..2753
Translation	MDEEEDNLSLLTALLEENESALDCNSEENNFLTRENGEPDAFDELFDADGDGESYTEEADDGETGETRDEKENLATLFGDMEDLTDEEEVPASQSTENRVLPAPAPRREKTNEELQEELRNLQEQMKALQEQLKVTTIKQTASPARLQKSPEKSPRPPLKERRVQRIQESTCFSAELDVPALPRTKRVARTPKASPPDPKSSSSRMTSAPSQPLQTISRNKPSGITRGQIVGTPGSSGETTQPICVEAFSGLRLRRPRVSSTEMNKKMTGRKLIRLSQIKEKMAREKLEEIDWVTFGVILKKVTPQSVNSGKTFSIWKLNDLRDLTQCVSLFLFGEVHKALWKTEQGTVVGILNANPMKPKDGSEEVCLSIDHPQKVLIMGEALDLGTCKAKKKNGEPCTQTVNLRDCEYCQYHVQAQYKKLSAKRADLQSTFSGGRIPKKFARRGTSLKERLCQDGFYYGGVSSASYAASIAAAVAPKKKIQTTLSNLVVKGTNLIIQETRQKLGIPQKSLSCSEEFKELMDLPTCGARNLKQHLAKATASGIMGSPKPAIKSISASALLKQQKQRMLEMRRRKSEEIQKRFLQSSSEVESPAVPSSSRQPPAQPPRTGSEFPRLEGAPATMTPKLGRGVLEGDDVLFYDESPPPRPKLSALAEAKKLAAITKLRAKGQVLTKTNPNSIKKKQKDPQDILEVKERVEKNTMFSSQAEDELEPARKKRREQLAYLESEEFQKILKAKSKHTGILKEAEAEMQERYFEPLVKKEQMEEKMRNIREVKCRVVTCKTCAYTHFKLLETCVSEQHEYHWHDGVKRFFKCPCGNRSISLDRLPNKHCSNCGLYKWERDGMLKEKTGPKIGGETLLPRGEEHAKFLNSLK

Target ORF information:

RefSeq Version	NM_018518.4
Organism	Homo sapiens(human)
Definition	Homo sapiens minichromosome maintenance 10 replication initiation factor (MCM10), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018518.4

ORF Insert Sequence:

ATGGATGAGG AGGAAGACAA TCTGTCTCTG CTGACCGCAC TGCTGGAAGA AAATGAGTCA 
GCCTTGGATT GTAATTCAGA AGAAAATAAC TTCTTGACGC GGGAAAATGG CGAGCCCGAC 
GCATTTGATG AGCTCTTTGA TGCCGACGGC GACGGTGAAT CTTATACAGA AGAGGCTGAT 
GATGGAGAAA CAGGAGAGAC AAGAGACGAA AAGGAAAATC TGGCCACTCT CTTTGGAGAT 
ATGGAGGACT TAACAGATGA AGAAGAAGTT CCCGCATCAC AGTCAACTGA AAATAGGGTC 
CTCCCTGCTC CTGCCCCCAG GCGAGAGAAA ACGAATGAAG AGTTGCAAGA GGAATTAAGG 
AATTTGCAAG AGCAAATGAA GGCCTTACAA GAGCAGCTAA AAGTAACAAC AATTAAACAG 
ACAGCAAGCC CAGCCCGTCT GCAAAAATCC CCTGAGAAGT CTCCCCGGCC ACCTCTTAAG 
GAGAGGAGAG TTCAGAGAAT TCAGGAGTCA ACATGCTTTT CTGCGGAGCT TGATGTCCCT 
GCGCTACCAA GAACCAAGAG GGTGGCTCGA ACACCAAAGG CTTCACCTCC AGATCCCAAA 
AGCTCATCTT CAAGGATGAC AAGTGCACCC TCCCAACCCC TACAGACGAT TTCTCGGAAC 
AAACCTAGTG GGATAACTAG AGGTCAAATT GTGGGGACCC CAGGAAGTTC TGGGGAAACG 
ACTCAACCCA TCTGTGTGGA AGCCTTCTCT GGTCTGCGGC TCAGGCGGCC TCGAGTATCC 
TCCACAGAAA TGAACAAGAA AATGACCGGC CGAAAACTGA TCAGACTGTC TCAGATCAAG 
GAAAAGATGG CCAGAGAGAA GCTGGAAGAA ATAGATTGGG TGACATTTGG GGTTATATTG 
AAGAAGGTTA CGCCACAGAG TGTGAATAGT GGAAAAACCT TCAGCATATG GAAACTGAAT 
GATCTTCGTG ACCTGACACA ATGTGTGTCC TTGTTCTTAT TTGGAGAAGT TCACAAAGCG 
CTCTGGAAGA CGGAGCAGGG GACTGTCGTA GGGATCCTCA ATGCCAACCC CATGAAGCCC 
AAGGATGGTT CAGAGGAGGT GTGTTTATCT ATCGATCATC CTCAGAAGGT CTTAATTATG 
GGTGAAGCTC TTGACCTGGG AACCTGTAAA GCCAAGAAGA AGAATGGAGA GCCGTGCACG 
CAGACTGTGA ATTTGCGTGA CTGTGAGTAC TGTCAGTACC ATGTCCAGGC TCAGTACAAG 
AAGCTCAGCG CAAAGCGTGC GGATCTGCAG TCCACCTTCT CTGGAGGACG AATTCCAAAG 
AAGTTTGCCC GCAGAGGCAC CAGCCTCAAA GAACGGCTGT GCCAAGATGG CTTTTACTAC 
GGAGGGGTTT CTTCTGCCTC GTATGCAGCT TCAATTGCAG CAGCTGTGGC TCCTAAGAAG 
AAGATTCAAA CCACTCTGAG TAATCTGGTT GTTAAGGGCA CAAACTTGAT CATCCAGGAA 
ACACGGCAAA AACTCGGAAT ACCCCAGAAG AGCCTGTCTT GCTCTGAGGA GTTCAAGGAA 
CTGATGGACC TGCCGACGTG TGGAGCCAGG AACTTAAAAC AACATTTAGC CAAAGCCACA 
GCTTCAGGGA TTATGGGGAG CCCAAAACCA GCCATCAAGT CCATCTCGGC CTCAGCACTC 
TTGAAGCAAC AGAAGCAGCG GATGTTGGAG ATGAGGAGAA GGAAATCAGA AGAAATACAG 
AAGCGATTTC TGCAGAGCTC AAGTGAAGTT GAGAGCCCAG CTGTGCCATC TTCATCAAGA 
CAGCCCCCTG CTCAGCCTCC ACGGACAGGA TCCGAGTTCC CCAGGCTGGA GGGAGCCCCG 
GCCACAATGA CGCCCAAGCT GGGGCGAGGT GTCTTGGAAG GAGATGATGT TCTCTTTTAT 
GATGAGTCAC CACCACCAAG ACCAAAACTG AGTGCTTTAG CAGAAGCCAA AAAGTTAGCT 
GCTATCACCA AATTAAGGGC AAAAGGCCAG GTTCTTACAA AAACAAACCC AAACAGCATT 
AAGAAGAAAC AAAAGGACCC TCAGGACATC CTGGAGGTGA AGGAACGTGT AGAAAAAAAC 
ACCATGTTTT CTTCTCAAGC TGAGGATGAA TTGGAGCCTG CCAGGAAAAA AAGGAGAGAA 
CAACTTGCCT ATCTGGAATC TGAGGAATTT CAGAAAATCC TAAAAGCAAA ATCAAAACAC 
ACAGGCATCC TGAAAGAGGC CGAGGCTGAG ATGCAGGAGC GCTACTTTGA GCCACTGGTG 
AAAAAAGAAC AAATGGAAGA AAAGATGAGA AACATCAGAG AAGTGAAGTG CCGTGTCGTG 
ACATGCAAGA CGTGCGCCTA TACCCACTTC AAGCTGCTGG AGACCTGCGT CAGTGAGCAG 
CATGAATACC ACTGGCATGA TGGTGTGAAG AGGTTTTTCA AATGTCCCTG TGGAAACAGA 
AGCATCTCCT TGGACAGACT CCCGAACAAG CACTGCAGTA ACTGTGGCCT CTACAAATGG 
GAACGGGACG GAATGCTAAA GGAAAAGACT GGTCCAAAGA TAGGAGGAGA AACTCTGTTA 
CCAAGAGGAG AAGAACATGC TAAATTTCTG AACAGCCTTA AATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MCM10 ( NM_018518.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_060988.3 Homo sapiens minichromosome maintenance 10 replication initiation factor (MCM10), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu09401
Clone ID Related Accession (Same CDS sequence)	NM_018518.4 , NM_018518.5
Accession Version	NM_018518.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2625bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-03
Organism	Homo sapiens(human)
Product	protein MCM10 homolog isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA024424.1, AB042719.1, AL136840.1 and AL138764.21. On Jun 2, 2019 this sequence version replaced NM_018518.4. Transcript Variant: This variant (2) encodes the predominant isoform (2). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB042719.1, BC143490.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGATGAGG AGGAAGACAA TCTGTCTCTG CTGACCGCAC TGCTGGAAGA AAATGAGTCA 
GCCTTGGATT GTAATTCAGA AGAAAATAAC TTCTTGACGC GGGAAAATGG CGAGCCCGAC 
GCATTTGATG AGCTCTTTGA TGCCGACGGC GACGGTGAAT CTTATACAGA AGAGGCTGAT 
GATGGAGAAA CAGGAGAGAC AAGAGACGAA AAGGAAAATC TGGCCACTCT CTTTGGAGAT 
ATGGAGGACT TAACAGATGA AGAAGAAGTT CCCGCATCAC AGTCAACTGA AAATAGGGTC 
CTCCCTGCTC CTGCCCCCAG GCGAGAGAAA ACGAATGAAG AGTTGCAAGA GGAATTAAGG 
AATTTGCAAG AGCAAATGAA GGCCTTACAA GAGCAGCTAA AAGTAACAAC AATTAAACAG 
ACAGCAAGCC CAGCCCGTCT GCAAAAATCC CCTGAGAAGT CTCCCCGGCC ACCTCTTAAG 
GAGAGGAGAG TTCAGAGAAT TCAGGAGTCA ACATGCTTTT CTGCGGAGCT TGATGTCCCT 
GCGCTACCAA GAACCAAGAG GGTGGCTCGA ACACCAAAGG CTTCACCTCC AGATCCCAAA 
AGCTCATCTT CAAGGATGAC AAGTGCACCC TCCCAACCCC TACAGACGAT TTCTCGGAAC 
AAACCTAGTG GGATAACTAG AGGTCAAATT GTGGGGACCC CAGGAAGTTC TGGGGAAACG 
ACTCAACCCA TCTGTGTGGA AGCCTTCTCT GGTCTGCGGC TCAGGCGGCC TCGAGTATCC 
TCCACAGAAA TGAACAAGAA AATGACCGGC CGAAAACTGA TCAGACTGTC TCAGATCAAG 
GAAAAGATGG CCAGAGAGAA GCTGGAAGAA ATAGATTGGG TGACATTTGG GGTTATATTG 
AAGAAGGTTA CGCCACAGAG TGTGAATAGT GGAAAAACCT TCAGCATATG GAAACTGAAT 
GATCTTCGTG ACCTGACACA ATGTGTGTCC TTGTTCTTAT TTGGAGAAGT TCACAAAGCG 
CTCTGGAAGA CGGAGCAGGG GACTGTCGTA GGGATCCTCA ATGCCAACCC CATGAAGCCC 
AAGGATGGTT CAGAGGAGGT GTGTTTATCT ATCGATCATC CTCAGAAGGT CTTAATTATG 
GGTGAAGCTC TTGACCTGGG AACCTGTAAA GCCAAGAAGA AGAATGGAGA GCCGTGCACG 
CAGACTGTGA ATTTGCGTGA CTGTGAGTAC TGTCAGTACC ATGTCCAGGC TCAGTACAAG 
AAGCTCAGCG CAAAGCGTGC GGATCTGCAG TCCACCTTCT CTGGAGGACG AATTCCAAAG 
AAGTTTGCCC GCAGAGGCAC CAGCCTCAAA GAACGGCTGT GCCAAGATGG CTTTTACTAC 
GGAGGGGTTT CTTCTGCCTC GTATGCAGCT TCAATTGCAG CAGCTGTGGC TCCTAAGAAG 
AAGATTCAAA CCACTCTGAG TAATCTGGTT GTTAAGGGCA CAAACTTGAT CATCCAGGAA 
ACACGGCAAA AACTCGGAAT ACCCCAGAAG AGCCTGTCTT GCTCTGAGGA GTTCAAGGAA 
CTGATGGACC TGCCGACGTG TGGAGCCAGG AACTTAAAAC AACATTTAGC CAAAGCCACA 
GCTTCAGGGA TTATGGGGAG CCCAAAACCA GCCATCAAGT CCATCTCGGC CTCAGCACTC 
TTGAAGCAAC AGAAGCAGCG GATGTTGGAG ATGAGGAGAA GGAAATCAGA AGAAATACAG 
AAGCGATTTC TGCAGAGCTC AAGTGAAGTT GAGAGCCCAG CTGTGCCATC TTCATCAAGA 
CAGCCCCCTG CTCAGCCTCC ACGGACAGGA TCCGAGTTCC CCAGGCTGGA GGGAGCCCCG 
GCCACAATGA CGCCCAAGCT GGGGCGAGGT GTCTTGGAAG GAGATGATGT TCTCTTTTAT 
GATGAGTCAC CACCACCAAG ACCAAAACTG AGTGCTTTAG CAGAAGCCAA AAAGTTAGCT 
GCTATCACCA AATTAAGGGC AAAAGGCCAG GTTCTTACAA AAACAAACCC AAACAGCATT 
AAGAAGAAAC AAAAGGACCC TCAGGACATC CTGGAGGTGA AGGAACGTGT AGAAAAAAAC 
ACCATGTTTT CTTCTCAAGC TGAGGATGAA TTGGAGCCTG CCAGGAAAAA AAGGAGAGAA 
CAACTTGCCT ATCTGGAATC TGAGGAATTT CAGAAAATCC TAAAAGCAAA ATCAAAACAC 
ACAGGCATCC TGAAAGAGGC CGAGGCTGAG ATGCAGGAGC GCTACTTTGA GCCACTGGTG 
AAAAAAGAAC AAATGGAAGA AAAGATGAGA AACATCAGAG AAGTGAAGTG CCGTGTCGTG 
ACATGCAAGA CGTGCGCCTA TACCCACTTC AAGCTGCTGG AGACCTGCGT CAGTGAGCAG 
CATGAATACC ACTGGCATGA TGGTGTGAAG AGGTTTTTCA AATGTCCCTG TGGAAACAGA 
AGCATCTCCT TGGACAGACT CCCGAACAAG CACTGCAGTA ACTGTGGCCT CTACAAATGG 
GAACGGGACG GAATGCTAAA GGAAAAGACT GGTCCAAAGA TAGGAGGAGA AACTCTGTTA 
CCAAGAGGAG AAGAACATGC TAAATTTCTG AACAGCCTTA AATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060988.3
CDS	125..2749
Translation	MDEEEDNLSLLTALLEENESALDCNSEENNFLTRENGEPDAFDELFDADGDGESYTEEADDGETGETRDEKENLATLFGDMEDLTDEEEVPASQSTENRVLPAPAPRREKTNEELQEELRNLQEQMKALQEQLKVTTIKQTASPARLQKSPEKSPRPPLKERRVQRIQESTCFSAELDVPALPRTKRVARTPKASPPDPKSSSSRMTSAPSQPLQTISRNKPSGITRGQIVGTPGSSGETTQPICVEAFSGLRLRRPRVSSTEMNKKMTGRKLIRLSQIKEKMAREKLEEIDWVTFGVILKKVTPQSVNSGKTFSIWKLNDLRDLTQCVSLFLFGEVHKALWKTEQGTVVGILNANPMKPKDGSEEVCLSIDHPQKVLIMGEALDLGTCKAKKKNGEPCTQTVNLRDCEYCQYHVQAQYKKLSAKRADLQSTFSGGRIPKKFARRGTSLKERLCQDGFYYGGVSSASYAASIAAAVAPKKKIQTTLSNLVVKGTNLIIQETRQKLGIPQKSLSCSEEFKELMDLPTCGARNLKQHLAKATASGIMGSPKPAIKSISASALLKQQKQRMLEMRRRKSEEIQKRFLQSSSEVESPAVPSSSRQPPAQPPRTGSEFPRLEGAPATMTPKLGRGVLEGDDVLFYDESPPPRPKLSALAEAKKLAAITKLRAKGQVLTKTNPNSIKKKQKDPQDILEVKERVEKNTMFSSQAEDELEPARKKRREQLAYLESEEFQKILKAKSKHTGILKEAEAEMQERYFEPLVKKEQMEEKMRNIREVKCRVVTCKTCAYTHFKLLETCVSEQHEYHWHDGVKRFFKCPCGNRSISLDRLPNKHCSNCGLYKWERDGMLKEKTGPKIGGETLLPRGEEHAKFLNSLK

Target ORF information:

RefSeq Version	NM_018518.5
Organism	Homo sapiens(human)
Definition	Homo sapiens minichromosome maintenance 10 replication initiation factor (MCM10), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018518.5

ORF Insert Sequence:

ATGGATGAGG AGGAAGACAA TCTGTCTCTG CTGACCGCAC TGCTGGAAGA AAATGAGTCA 
GCCTTGGATT GTAATTCAGA AGAAAATAAC TTCTTGACGC GGGAAAATGG CGAGCCCGAC 
GCATTTGATG AGCTCTTTGA TGCCGACGGC GACGGTGAAT CTTATACAGA AGAGGCTGAT 
GATGGAGAAA CAGGAGAGAC AAGAGACGAA AAGGAAAATC TGGCCACTCT CTTTGGAGAT 
ATGGAGGACT TAACAGATGA AGAAGAAGTT CCCGCATCAC AGTCAACTGA AAATAGGGTC 
CTCCCTGCTC CTGCCCCCAG GCGAGAGAAA ACGAATGAAG AGTTGCAAGA GGAATTAAGG 
AATTTGCAAG AGCAAATGAA GGCCTTACAA GAGCAGCTAA AAGTAACAAC AATTAAACAG 
ACAGCAAGCC CAGCCCGTCT GCAAAAATCC CCTGAGAAGT CTCCCCGGCC ACCTCTTAAG 
GAGAGGAGAG TTCAGAGAAT TCAGGAGTCA ACATGCTTTT CTGCGGAGCT TGATGTCCCT 
GCGCTACCAA GAACCAAGAG GGTGGCTCGA ACACCAAAGG CTTCACCTCC AGATCCCAAA 
AGCTCATCTT CAAGGATGAC AAGTGCACCC TCCCAACCCC TACAGACGAT TTCTCGGAAC 
AAACCTAGTG GGATAACTAG AGGTCAAATT GTGGGGACCC CAGGAAGTTC TGGGGAAACG 
ACTCAACCCA TCTGTGTGGA AGCCTTCTCT GGTCTGCGGC TCAGGCGGCC TCGAGTATCC 
TCCACAGAAA TGAACAAGAA AATGACCGGC CGAAAACTGA TCAGACTGTC TCAGATCAAG 
GAAAAGATGG CCAGAGAGAA GCTGGAAGAA ATAGATTGGG TGACATTTGG GGTTATATTG 
AAGAAGGTTA CGCCACAGAG TGTGAATAGT GGAAAAACCT TCAGCATATG GAAACTGAAT 
GATCTTCGTG ACCTGACACA ATGTGTGTCC TTGTTCTTAT TTGGAGAAGT TCACAAAGCG 
CTCTGGAAGA CGGAGCAGGG GACTGTCGTA GGGATCCTCA ATGCCAACCC CATGAAGCCC 
AAGGATGGTT CAGAGGAGGT GTGTTTATCT ATCGATCATC CTCAGAAGGT CTTAATTATG 
GGTGAAGCTC TTGACCTGGG AACCTGTAAA GCCAAGAAGA AGAATGGAGA GCCGTGCACG 
CAGACTGTGA ATTTGCGTGA CTGTGAGTAC TGTCAGTACC ATGTCCAGGC TCAGTACAAG 
AAGCTCAGCG CAAAGCGTGC GGATCTGCAG TCCACCTTCT CTGGAGGACG AATTCCAAAG 
AAGTTTGCCC GCAGAGGCAC CAGCCTCAAA GAACGGCTGT GCCAAGATGG CTTTTACTAC 
GGAGGGGTTT CTTCTGCCTC GTATGCAGCT TCAATTGCAG CAGCTGTGGC TCCTAAGAAG 
AAGATTCAAA CCACTCTGAG TAATCTGGTT GTTAAGGGCA CAAACTTGAT CATCCAGGAA 
ACACGGCAAA AACTCGGAAT ACCCCAGAAG AGCCTGTCTT GCTCTGAGGA GTTCAAGGAA 
CTGATGGACC TGCCGACGTG TGGAGCCAGG AACTTAAAAC AACATTTAGC CAAAGCCACA 
GCTTCAGGGA TTATGGGGAG CCCAAAACCA GCCATCAAGT CCATCTCGGC CTCAGCACTC 
TTGAAGCAAC AGAAGCAGCG GATGTTGGAG ATGAGGAGAA GGAAATCAGA AGAAATACAG 
AAGCGATTTC TGCAGAGCTC AAGTGAAGTT GAGAGCCCAG CTGTGCCATC TTCATCAAGA 
CAGCCCCCTG CTCAGCCTCC ACGGACAGGA TCCGAGTTCC CCAGGCTGGA GGGAGCCCCG 
GCCACAATGA CGCCCAAGCT GGGGCGAGGT GTCTTGGAAG GAGATGATGT TCTCTTTTAT 
GATGAGTCAC CACCACCAAG ACCAAAACTG AGTGCTTTAG CAGAAGCCAA AAAGTTAGCT 
GCTATCACCA AATTAAGGGC AAAAGGCCAG GTTCTTACAA AAACAAACCC AAACAGCATT 
AAGAAGAAAC AAAAGGACCC TCAGGACATC CTGGAGGTGA AGGAACGTGT AGAAAAAAAC 
ACCATGTTTT CTTCTCAAGC TGAGGATGAA TTGGAGCCTG CCAGGAAAAA AAGGAGAGAA 
CAACTTGCCT ATCTGGAATC TGAGGAATTT CAGAAAATCC TAAAAGCAAA ATCAAAACAC 
ACAGGCATCC TGAAAGAGGC CGAGGCTGAG ATGCAGGAGC GCTACTTTGA GCCACTGGTG 
AAAAAAGAAC AAATGGAAGA AAAGATGAGA AACATCAGAG AAGTGAAGTG CCGTGTCGTG 
ACATGCAAGA CGTGCGCCTA TACCCACTTC AAGCTGCTGG AGACCTGCGT CAGTGAGCAG 
CATGAATACC ACTGGCATGA TGGTGTGAAG AGGTTTTTCA AATGTCCCTG TGGAAACAGA 
AGCATCTCCT TGGACAGACT CCCGAACAAG CACTGCAGTA ACTGTGGCCT CTACAAATGG 
GAACGGGACG GAATGCTAAA GGAAAAGACT GGTCCAAAGA TAGGAGGAGA AACTCTGTTA 
CCAAGAGGAG AAGAACATGC TAAATTTCTG AACAGCCTTA AATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Mcm2-7-interacting domain of human mini-chromosome maintenance 10 (Mcm10) protein is important for stable chromatin association and origin firing.
The Journal of biological chemistry292(31)13008-13021(2017 08)
Izumi M,Mizuno T,Yanagi KI,Sugimura K,Okumura K,Imamoto N,Abe T,Hanaoka F

MCM10 overexpression implicates adverse prognosis in urothelial carcinoma.
Oncotarget7(47)77777-77792(2016 Nov)
Li WM,Huang CN,Ke HL,Li CC,Wei YC,Yeh HC,Chang LL,Huang CH,Liang PI,Yeh BW,Chan TC,Li CF,Wu WJ

HIV-1 Vpr Protein Enhances Proteasomal Degradation of MCM10 DNA Replication Factor through the Cul4-DDB1[VprBP] E3 Ubiquitin Ligase to Induce G2/M Cell Cycle Arrest.
The Journal of biological chemistry290(28)17380-9(2015 Jul)
Romani B,Shaykh Baygloo N,Aghasadeghi MR,Allahbakhshi E

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MCM10 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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