BLOC1S4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	BLOC1S4
Entrez Gene ID	55330
Full Name	biogenesis of lysosomal organelles complex 1 subunit 4
Synonyms	BCAS4L,BLOS4,CNO
General protein information	Preferred Names biogenesis of lysosomal organelles complex 1 subunit 4 Names biogenesis of lysosome-related organelles complex 1 subunit 4 BLOC-1 subunit 4 biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino cappuccino homolog protein cappuccino homolog
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4p16.1
Summary	This intronless gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. A similar protein in mouse is a component of a protein complex termed biogenesis of lysosome-related organelles complex 1 (BLOC-1), and is a model for Hermansky-Pudlak syndrome. The encoded protein may play a role in intracellular vesicular trafficking. [provided by RefSeq, Jul 2008]. COMPLETENESS: complete on the 3' end.
Disorder MIM:	605695

mRNA and Protein(s)

mRNA	Protein	Name
NM_018366.3	NP_060836.1	biogenesis of lysosome-related organelles complex 1 subunit 4
NM_018366.2	NP_060836.1	biogenesis of lysosome-related organelles complex 1 subunit 4

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	BLOC1S4	XP_005618501.1
	CNO	XP_001091640.1
Rattus norvegicus (Norway rat)	Bloc1s4	NP_001094236.1
Danio rerio (zebrafish)	bloc1s4	NP_001003475.1
Xenopus tropicalis (tropical clawed frog)	bloc1s4	NP_001037953.1
Gallus gallus (chicken)	CNO	XP_419086.4
Pan troglodytes (chimpanzee)	CNO	XP_517096.2
Homo sapiens (human)	BLOC1S4	NP_060836.1
Bos taurus (cattle)	CNO	NP_001074200.1
Mus musculus (house mouse)	Bloc1s4	NP_598485.1

Gene Ontology
Bibliography

Related articles in PubMed

Assembly and architecture of biogenesis of lysosome-related organelles complex-1 (BLOC-1).
Lee HH, Nemecek D, Schindler C, Smith WJ, Ghirlando R, Steven AC, Bonifacino JS, Hurley JH
The Journal of biological chemistry287(8)5882-90(2012 Feb)

Targeting protein-trafficking pathways alters melanoma treatment sensitivity.
Huang ZM, Chinen M, Chang PJ, Xie T, Zhong L, Demetriou S, Patel MP, Scherzer R, Sviderskaya EV, Bennett DC, Millhauser GL, Oh DH, Cleaver JE, Wei ML
Proceedings of the National Academy of Sciences of the United States of America109(2)553-8(2012 Jan)

Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1).
Starcevic M, Dell'Angelica EC
The Journal of biological chemistry279(27)28393-401(2004 Jul)

Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1).
Li W, Zhang Q, Oiso N, Novak EK, Gautam R, O'Brien EP, Tinsley CL, Blake DJ, Spritz RA, Copeland NG, Jenkins NA, Amato D, Roe BA, Starcevic M, Dell'Angelica EC, Elliott RW, Mishra V, Kingsmore SF, Paylor RE, Swank RT
Nature genetics35(1)84-9(2003 Sep)

Cappuccino, a mouse model of Hermansky-Pudlak syndrome, encodes a novel protein that is part of the pallidin-muted complex (BLOC-1).
Ciciotte SL, Gwynn B, Moriyama K, Huizing M, Gahl WA, Bonifacino JS, Peters LL
Blood101(11)4402-7(2003 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Melanoma cells depleted of cappuccino protein have increased nuclear localization of cis-diaminedichloroplatinum II, increased nuclear DNA damage by platination, and increased apoptosis, resulting in increased treatment sensitivity.
Title: Targeting protein-trafficking pathways alters melanoma treatment sensitivity.

The following BLOC1S4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BLOC1S4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29396	NM_018366.3 Latest version!	Homo sapiens biogenesis of lysosomal organelles complex 1 subunit 4 (BLOC1S4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
View Old Accession Versions >>
OHu29396	NM_018366.2	Homo sapiens biogenesis of lysosomal organelles complex 1 subunit 4 (BLOC1S4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

BLOC1S4 ( NM_018366.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_060836.1 Homo sapiens biogenesis of lysosomal organelles complex 1 subunit 4 (BLOC1S4), mRNA.

Price & Availability↑

CloneID	OHu29396
Clone ID Related Accession (Same CDS sequence)	NM_018366.3 , NM_018366.2
Accession Version	NM_018366.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 654bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	biogenesis of lysosome-related organelles complex 1 subunit 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK002092.1, BC001818.2, AI679712.1 and AC093323.3. On May 17, 2019 this sequence version replaced NM_018366.2. ##Evidence-Data-START## Transcript is intronless :: BC067815.1, ERR279848.6889.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000320776.5/ ENSP00000318128.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGGGTA GCTTTTCGGA TGGCGGAGCG CTGCCGGAGG GGCTCGCGGA AGAGGCCGAG 
CCGCAGGGCG CCGCCTGGAG CGGGGACAGT GGCACTGTTT CCCAGAGCCA CAGCAGCGCC 
TCGGGGCCGT GGGAGGACGA GGGCGCGGAG GACGGCGCGC CGGGCCGCGA CCTGCCGCTG 
CTTCGCCGCG CCGCTGCGGG CTACGCCGCC TGCCTGCTGC CCGGGGCCGG GGCGCGGCCC 
GAGGTCGAGG CCCTGGACGC GAGCCTAGAG GACCTGCTTA CCAGAGTGGA CGAGTTCGTG 
GGCATGCTGG ACATGCTTCG CGGCGACTCG TCCCACGTCG TCAGCGAGGG CGTGCCGCGC 
ATCCACGCGA AGGCCGCCGA GATGCGGCGC ATCTACAGCA GGATCGACCG GCTGGAGGCC 
TTCGTGAGGA TGGTGGGGGG CCGCGTGGCC AGGATGGAGG AGCAGGTCAC CAAGGCCGAG 
GCCGAGCTGG GCACCTTCCC CAGGGCGTTC AAGAAGCTCC TGCACACGAT GAACGTGCCC 
TCGCTCTTTA GCAAGTCTGC TCCCTCGAGG CCACAGCAAG CCGGCTACGA AGCCCCCGTC 
CTGTTTCGGA CCGAAGACTA CTTCCCTTGT TGCAGTGAAA GGCCTCAGCT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060836.1
CDS	37..690
Translation	MEGSFSDGGALPEGLAEEAEPQGAAWSGDSGTVSQSHSSASGPWEDEGAEDGAPGRDLPLLRRAAAGYAACLLPGAGARPEVEALDASLEDLLTRVDEFVGMLDMLRGDSSHVVSEGVPRIHAKAAEMRRIYSRIDRLEAFVRMVGGRVARMEEQVTKAEAELGTFPRAFKKLLHTMNVPSLFSKSAPSRPQQAGYEAPVLFRTEDYFPCCSERPQL

Target ORF information:

RefSeq Version	NM_018366.3
Organism	Homo sapiens(human)
Definition	Homo sapiens biogenesis of lysosomal organelles complex 1 subunit 4 (BLOC1S4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018366.3

ORF Insert Sequence:

ATGGAGGGTA GCTTTTCGGA TGGCGGAGCG CTGCCGGAGG GGCTCGCGGA AGAGGCCGAG 
CCGCAGGGCG CCGCCTGGAG CGGGGACAGT GGCACTGTTT CCCAGAGCCA CAGCAGCGCC 
TCGGGGCCGT GGGAGGACGA GGGCGCGGAG GACGGCGCGC CGGGCCGCGA CCTGCCGCTG 
CTTCGCCGCG CCGCTGCGGG CTACGCCGCC TGCCTGCTGC CCGGGGCCGG GGCGCGGCCC 
GAGGTCGAGG CCCTGGACGC GAGCCTAGAG GACCTGCTTA CCAGAGTGGA CGAGTTCGTG 
GGCATGCTGG ACATGCTTCG CGGCGACTCG TCCCACGTCG TCAGCGAGGG CGTGCCGCGC 
ATCCACGCGA AGGCCGCCGA GATGCGGCGC ATCTACAGCA GGATCGACCG GCTGGAGGCC 
TTCGTGAGGA TGGTGGGGGG CCGCGTGGCC AGGATGGAGG AGCAGGTCAC CAAGGCCGAG 
GCCGAGCTGG GCACCTTCCC CAGGGCGTTC AAGAAGCTCC TGCACACGAT GAACGTGCCC 
TCGCTCTTTA GCAAGTCTGC TCCCTCGAGG CCACAGCAAG CCGGCTACGA AGCCCCCGTC 
CTGTTTCGGA CCGAAGACTA CTTCCCTTGT TGCAGTGAAA GGCCTCAGCT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BLOC1S4 ( NM_018366.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_060836.1 Homo sapiens biogenesis of lysosomal organelles complex 1 subunit 4 (BLOC1S4), mRNA.

Price & Availability↑

CloneID	OHu29396
Clone ID Related Accession (Same CDS sequence)	NM_018366.3 , NM_018366.2
Accession Version	NM_018366.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 654bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Homo sapiens(human)
Product	biogenesis of lysosome-related organelles complex 1 subunit 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK002092.1, BC001818.2 and AI679712.1. On Jan 13, 2004 this sequence version replaced NM_018366.1. COMPLETENESS: complete on the 3' end.

ATGGAGGGTA GCTTTTCGGA TGGCGGAGCG CTGCCGGAGG GGCTCGCGGA AGAGGCCGAG 
CCGCAGGGCG CCGCCTGGAG CGGGGACAGT GGCACTGTTT CCCAGAGCCA CAGCAGCGCC 
TCGGGGCCGT GGGAGGACGA GGGCGCGGAG GACGGCGCGC CGGGCCGCGA CCTGCCGCTG 
CTTCGCCGCG CCGCTGCGGG CTACGCCGCC TGCCTGCTGC CCGGGGCCGG GGCGCGGCCC 
GAGGTCGAGG CCCTGGACGC GAGCCTAGAG GACCTGCTTA CCAGAGTGGA CGAGTTCGTG 
GGCATGCTGG ACATGCTTCG CGGCGACTCG TCCCACGTCG TCAGCGAGGG CGTGCCGCGC 
ATCCACGCGA AGGCCGCCGA GATGCGGCGC ATCTACAGCA GGATCGACCG GCTGGAGGCC 
TTCGTGAGGA TGGTGGGGGG CCGCGTGGCC AGGATGGAGG AGCAGGTCAC CAAGGCCGAG 
GCCGAGCTGG GCACCTTCCC CAGGGCGTTC AAGAAGCTCC TGCACACGAT GAACGTGCCC 
TCGCTCTTTA GCAAGTCTGC TCCCTCGAGG CCACAGCAAG CCGGCTACGA AGCCCCCGTC 
CTGTTTCGGA CCGAAGACTA CTTCCCTTGT TGCAGTGAAA GGCCTCAGCT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060836.1
CDS	96..749
Translation	MEGSFSDGGALPEGLAEEAEPQGAAWSGDSGTVSQSHSSASGPWEDEGAEDGAPGRDLPLLRRAAAGYAACLLPGAGARPEVEALDASLEDLLTRVDEFVGMLDMLRGDSSHVVSEGVPRIHAKAAEMRRIYSRIDRLEAFVRMVGGRVARMEEQVTKAEAELGTFPRAFKKLLHTMNVPSLFSKSAPSRPQQAGYEAPVLFRTEDYFPCCSERPQL

Target ORF information:

RefSeq Version	NM_018366.2
Organism	Homo sapiens(human)
Definition	Homo sapiens biogenesis of lysosomal organelles complex 1 subunit 4 (BLOC1S4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018366.2

ORF Insert Sequence:

ATGGAGGGTA GCTTTTCGGA TGGCGGAGCG CTGCCGGAGG GGCTCGCGGA AGAGGCCGAG 
CCGCAGGGCG CCGCCTGGAG CGGGGACAGT GGCACTGTTT CCCAGAGCCA CAGCAGCGCC 
TCGGGGCCGT GGGAGGACGA GGGCGCGGAG GACGGCGCGC CGGGCCGCGA CCTGCCGCTG 
CTTCGCCGCG CCGCTGCGGG CTACGCCGCC TGCCTGCTGC CCGGGGCCGG GGCGCGGCCC 
GAGGTCGAGG CCCTGGACGC GAGCCTAGAG GACCTGCTTA CCAGAGTGGA CGAGTTCGTG 
GGCATGCTGG ACATGCTTCG CGGCGACTCG TCCCACGTCG TCAGCGAGGG CGTGCCGCGC 
ATCCACGCGA AGGCCGCCGA GATGCGGCGC ATCTACAGCA GGATCGACCG GCTGGAGGCC 
TTCGTGAGGA TGGTGGGGGG CCGCGTGGCC AGGATGGAGG AGCAGGTCAC CAAGGCCGAG 
GCCGAGCTGG GCACCTTCCC CAGGGCGTTC AAGAAGCTCC TGCACACGAT GAACGTGCCC 
TCGCTCTTTA GCAAGTCTGC TCCCTCGAGG CCACAGCAAG CCGGCTACGA AGCCCCCGTC 
CTGTTTCGGA CCGAAGACTA CTTCCCTTGT TGCAGTGAAA GGCCTCAGCT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Assembly and architecture of biogenesis of lysosome-related organelles complex-1 (BLOC-1).
The Journal of biological chemistry287(8)5882-90(2012 Feb)
Lee HH,Nemecek D,Schindler C,Smith WJ,Ghirlando R,Steven AC,Bonifacino JS,Hurley JH

Targeting protein-trafficking pathways alters melanoma treatment sensitivity.
Proceedings of the National Academy of Sciences of the United States of America109(2)553-8(2012 Jan)
Huang ZM,Chinen M,Chang PJ,Xie T,Zhong L,Demetriou S,Patel MP,Scherzer R,Sviderskaya EV,Bennett DC,Millhauser GL,Oh DH,Cleaver JE,Wei ML

Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1).
The Journal of biological chemistry279(27)28393-401(2004 Jul)
Starcevic M,Dell'Angelica EC

Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1).
Nature genetics35(1)84-9(2003 Sep)
Li W,Zhang Q,Oiso N,Novak EK,Gautam R,O'Brien EP,Tinsley CL,Blake DJ,Spritz RA,Copeland NG,Jenkins NA,Amato D,Roe BA,Starcevic M,Dell'Angelica EC,Elliott RW,Mishra V,Kingsmore SF,Paylor RE,Swank RT

Cappuccino, a mouse model of Hermansky-Pudlak syndrome, encodes a novel protein that is part of the pallidin-muted complex (BLOC-1).
Blood101(11)4402-7(2003 Jun)
Ciciotte SL,Gwynn B,Moriyama K,Huizing M,Gahl WA,Bonifacino JS,Peters LL

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BLOC1S4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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