MRGBP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MRGBP
Entrez Gene ID	55257
Full Name	MRG domain binding protein
Synonyms	C20orf20,Eaf7,MRG15BP,URCC4
General protein information	Preferred Names MRG domain binding protein Names MRG/MORF4L-binding protein MRG-binding protein MRG/MORF4L binding protein up-regulated in colon cancer 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20q13.33
Disorder MIM:	611157

mRNA and Protein(s)

mRNA	Protein	Name
NM_018270.4	NP_060740.1	MRG/MORF4L-binding protein
NM_018270.5	NP_060740.1	MRG/MORF4L-binding protein
NM_018270.6	NP_060740.1	MRG/MORF4L-binding protein

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	C20ORF20	XP_417408.2
Homo sapiens (human)	MRGBP	NP_060740.1
Mus musculus (house mouse)	Mrgbp	NP_082755.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012361	XP_320195.4
Canis lupus familiaris (dog)	MRGBP	XP_005635327.1
Drosophila melanogaster (fruit fly)	MrgBP	NP_610417.1
Pan troglodytes (chimpanzee)	MRGBP	XP_003317095.1
	LOC698808	XP_002808000.1
Danio rerio (zebrafish)	mrgbp	NP_957030.1
Bos taurus (cattle)	C13H20orf20	NP_001193490.1
Rattus norvegicus (Norway rat)	Mrgbp	NP_001167210.1
Rattus norvegicus (Norway rat)	LOC100910098	XP_003749692.1

Gene Ontology
Bibliography

Related articles in PubMed

MiR-137 Functions as a Tumor Suppressor in Pancreatic Cancer by Targeting MRGBP.
Ding F, Zhang S, Gao S, Shang J, Li Y, Cui N, Zhao Q
Journal of cellular biochemistry(2018 Jan)

MRGBP as a potential biomarker for the malignancy of pancreatic ductal adenocarcinoma.
Ding F, Zhang S, Gao S, Shang J, Li Y, Cui N, Zhao Q
Oncotarget8(38)64224-64236(2017 Sep)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Structural Basis for Multi-specificity of MRG Domains.
Xie T, Zmyslowski AM, Zhang Y, Radhakrishnan I
Structure (London, England : 1993)23(6)1049-57(2015 Jun)

ANP32E is a histone chaperone that removes H2A.Z from chromatin.
Obri A, Ouararhni K, Papin C, Diebold ML, Padmanabhan K, Marek M, Stoll I, Roy L, Reilly PT, Mak TW, Dimitrov S, Romier C, Hamiche A
Nature505(7485)648-53(2014 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

role in tumorogenesis of cutaneous squamous cell carcinoma
Title: Integrative mRNA profiling comparing cultured primary cells with clinical samples reveals PLK1 and C20orf20 as therapeutic targets in cutaneous squamous cell carcinoma.

MRGBP contributes to colorectal carcinogenesis through rendering advantages in cell proliferation and/or division of cancer cells.
Title: MRG-binding protein contributes to colorectal cancer development.

These results suggest that C20orf20 protein has an important function in proliferation of cancer cells through the regulation of BRD8 protein.
Title: C20orf20 (MRG-binding protein) as a potential therapeutic target for colorectal cancer.

MRGBP is encoded by the FLJ10914 ORF and is a new component of the TRRAP/TIP60 HAT complex
Title: Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex.

The following MRGBP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MRGBP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13249	NM_018270.6 Latest version!	Homo sapiens MRG domain binding protein (MRGBP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu13249	NM_018270.4	Homo sapiens MRG/MORF4L binding protein (MRGBP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu13249	NM_018270.5	Homo sapiens MRG domain binding protein (MRGBP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MRGBP ( NM_018270.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_060740.1 Homo sapiens MRG/MORF4L binding protein (MRGBP), mRNA.

Price & Availability↑

CloneID	OHu13249
Clone ID Related Accession (Same CDS sequence)	NM_018270.4 , NM_018270.5 , NM_018270.6
Accession Version	NM_018270.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 615bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	MRG/MORF4L-binding protein
Comment

ATGGGAGAGG CCGAGGTGGG CGGCGGGGGC GCCGCAGGCG ACAAGGGCCC GGGGGAGGCG 
GCCACCAGCC CGGCGGAGGA GACAGTGGTG TGGAGCCCCG AGGTGGAGGT GTGCCTCTTC 
CACGCCATGC TGGGCCACAA GCCCGTCGGT GTGAACCGAC ACTTCCACAT GATTTGTATT 
CGGGACAAGT TCAGCCAGAA CATCGGGCGG CAGGTCCCAT CCAAGGTCAT CTGGGACCAT 
CTGAGCACCA TGTACGACAT GCAGGCGCTG CATGAGTCTG AGATTCTTCC ATTCCCGAAT 
CCAGAGAGGA ACTTCGTCCT TCCAGAAGAG ATCATTCAGG AGGTCCGAGA AGGAAAAGTG 
ATGATAGAAG AGGAGATGAA AGAGGAGATG AAGGAAGACG TGGACCCCCA CAATGGGGCT 
GACGATGTTT TTTCATCTTC AGGGAGTTTG GGGAAAGCAT CAGAAAAATC CAGCAAAGAC 
AAAGAGAAGA ACTCCTCAGA CTTGGGGTGC AAAGAAGGCG CAGACAAGCG GAAGCGCAGC 
CGGGTCACCG ACAAAGTCCT GACCGCAAAC AGCAACCCTT CCAGTCCCAG TGCTGCCAAG 
CGGCGCCGCA CGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060740.1
Translation	MGEAEVGGGGAAGDKGPGEAATSPAEETVVWSPEVEVCLFHAMLGHKPVGVNRHFHMICIRDKFSQNIGRQVPSKVIWDHLSTMYDMQALHESEILPFPNPERNFVLPEEIIQEVREGKVMIEEEMKEEMKEDVDPHNGADDVFSSSGSLGKASEKSSKDKEKNSSDLGCKEGADKRKRSRVTDKVLTANSNPSSPSAAKRRRT

Target ORF information:

RefSeq Version	NM_018270.4
Organism	Homo sapiens(Human)
Definition	Homo sapiens MRG/MORF4L binding protein (MRGBP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018270.4

ORF Insert Sequence:

ATGGGAGAGG CCGAGGTGGG CGGCGGGGGC GCCGCAGGCG ACAAGGGCCC GGGGGAGGCG 
GCCACCAGCC CGGCGGAGGA GACAGTGGTG TGGAGCCCCG AGGTGGAGGT GTGCCTCTTC 
CACGCCATGC TGGGCCACAA GCCCGTCGGT GTGAACCGAC ACTTCCACAT GATTTGTATT 
CGGGACAAGT TCAGCCAGAA CATCGGGCGG CAGGTCCCAT CCAAGGTCAT CTGGGACCAT 
CTGAGCACCA TGTACGACAT GCAGGCGCTG CATGAGTCTG AGATTCTTCC ATTCCCGAAT 
CCAGAGAGGA ACTTCGTCCT TCCAGAAGAG ATCATTCAGG AGGTCCGAGA AGGAAAAGTG 
ATGATAGAAG AGGAGATGAA AGAGGAGATG AAGGAAGACG TGGACCCCCA CAATGGGGCT 
GACGATGTTT TTTCATCTTC AGGGAGTTTG GGGAAAGCAT CAGAAAAATC CAGCAAAGAC 
AAAGAGAAGA ACTCCTCAGA CTTGGGGTGC AAAGAAGGCG CAGACAAGCG GAAGCGCAGC 
CGGGTCACCG ACAAAGTCCT GACCGCAAAC AGCAACCCTT CCAGTCCCAG TGCTGCCAAG 
CGGCGCCGCA CGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRGBP ( NM_018270.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_060740.1 Homo sapiens MRG domain binding protein (MRGBP), mRNA.

Price & Availability↑

CloneID	OHu13249
Clone ID Related Accession (Same CDS sequence)	NM_018270.4 , NM_018270.5 , NM_018270.6
Accession Version	NM_018270.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 615bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-07
Organism	Homo sapiens(human)
Product	MRG/MORF4L-binding protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BU902487.1, AK001776.1, BC014235.2, AL035669.43 and BQ445915.1. On Apr 14, 2016 this sequence version replaced NM_018270.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.199607.1, SRR1660809.19920.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGAGAGG CCGAGGTGGG CGGCGGGGGC GCCGCAGGCG ACAAGGGCCC GGGGGAGGCG 
GCCACCAGCC CGGCGGAGGA GACAGTGGTG TGGAGCCCCG AGGTGGAGGT GTGCCTCTTC 
CACGCCATGC TGGGCCACAA GCCCGTCGGT GTGAACCGAC ACTTCCACAT GATTTGTATT 
CGGGACAAGT TCAGCCAGAA CATCGGGCGG CAGGTCCCAT CCAAGGTCAT CTGGGACCAT 
CTGAGCACCA TGTACGACAT GCAGGCGCTG CATGAGTCTG AGATTCTTCC ATTCCCGAAT 
CCAGAGAGGA ACTTCGTCCT TCCAGAAGAG ATCATTCAGG AGGTCCGAGA AGGAAAAGTG 
ATGATAGAAG AGGAGATGAA AGAGGAGATG AAGGAAGACG TGGACCCCCA CAATGGGGCT 
GACGATGTTT TTTCATCTTC AGGGAGTTTG GGGAAAGCAT CAGAAAAATC CAGCAAAGAC 
AAAGAGAAGA ACTCCTCAGA CTTGGGGTGC AAAGAAGGCG CAGACAAGCG GAAGCGCAGC 
CGGGTCACCG ACAAAGTCCT GACCGCAAAC AGCAACCCTT CCAGTCCCAG TGCTGCCAAG 
CGGCGCCGCA CGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060740.1
CDS	120..734
Translation	MGEAEVGGGGAAGDKGPGEAATSPAEETVVWSPEVEVCLFHAMLGHKPVGVNRHFHMICIRDKFSQNIGRQVPSKVIWDHLSTMYDMQALHESEILPFPNPERNFVLPEEIIQEVREGKVMIEEEMKEEMKEDVDPHNGADDVFSSSGSLGKASEKSSKDKEKNSSDLGCKEGADKRKRSRVTDKVLTANSNPSSPSAAKRRRT

Target ORF information:

RefSeq Version	NM_018270.5
Organism	Homo sapiens(human)
Definition	Homo sapiens MRG domain binding protein (MRGBP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018270.5

ORF Insert Sequence:

ATGGGAGAGG CCGAGGTGGG CGGCGGGGGC GCCGCAGGCG ACAAGGGCCC GGGGGAGGCG 
GCCACCAGCC CGGCGGAGGA GACAGTGGTG TGGAGCCCCG AGGTGGAGGT GTGCCTCTTC 
CACGCCATGC TGGGCCACAA GCCCGTCGGT GTGAACCGAC ACTTCCACAT GATTTGTATT 
CGGGACAAGT TCAGCCAGAA CATCGGGCGG CAGGTCCCAT CCAAGGTCAT CTGGGACCAT 
CTGAGCACCA TGTACGACAT GCAGGCGCTG CATGAGTCTG AGATTCTTCC ATTCCCGAAT 
CCAGAGAGGA ACTTCGTCCT TCCAGAAGAG ATCATTCAGG AGGTCCGAGA AGGAAAAGTG 
ATGATAGAAG AGGAGATGAA AGAGGAGATG AAGGAAGACG TGGACCCCCA CAATGGGGCT 
GACGATGTTT TTTCATCTTC AGGGAGTTTG GGGAAAGCAT CAGAAAAATC CAGCAAAGAC 
AAAGAGAAGA ACTCCTCAGA CTTGGGGTGC AAAGAAGGCG CAGACAAGCG GAAGCGCAGC 
CGGGTCACCG ACAAAGTCCT GACCGCAAAC AGCAACCCTT CCAGTCCCAG TGCTGCCAAG 
CGGCGCCGCA CGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRGBP ( NM_018270.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_060740.1 Homo sapiens MRG domain binding protein (MRGBP), mRNA.

Price & Availability↑

CloneID	OHu13249
Clone ID Related Accession (Same CDS sequence)	NM_018270.4 , NM_018270.5 , NM_018270.6
Accession Version	NM_018270.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 615bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	MRG/MORF4L-binding protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK001776.1, BC014235.2, AL035669.43 and BQ445915.1. On Nov 23, 2018 this sequence version replaced NM_018270.5. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.19920.1, SRR1660803.199607.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000370487.5/ ENSP00000359518.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGAGAGG CCGAGGTGGG CGGCGGGGGC GCCGCAGGCG ACAAGGGCCC GGGGGAGGCG 
GCCACCAGCC CGGCGGAGGA GACAGTGGTG TGGAGCCCCG AGGTGGAGGT GTGCCTCTTC 
CACGCCATGC TGGGCCACAA GCCCGTCGGT GTGAACCGAC ACTTCCACAT GATTTGTATT 
CGGGACAAGT TCAGCCAGAA CATCGGGCGG CAGGTCCCAT CCAAGGTCAT CTGGGACCAT 
CTGAGCACCA TGTACGACAT GCAGGCGCTG CATGAGTCTG AGATTCTTCC ATTCCCGAAT 
CCAGAGAGGA ACTTCGTCCT TCCAGAAGAG ATCATTCAGG AGGTCCGAGA AGGAAAAGTG 
ATGATAGAAG AGGAGATGAA AGAGGAGATG AAGGAAGACG TGGACCCCCA CAATGGGGCT 
GACGATGTTT TTTCATCTTC AGGGAGTTTG GGGAAAGCAT CAGAAAAATC CAGCAAAGAC 
AAAGAGAAGA ACTCCTCAGA CTTGGGGTGC AAAGAAGGCG CAGACAAGCG GAAGCGCAGC 
CGGGTCACCG ACAAAGTCCT GACCGCAAAC AGCAACCCTT CCAGTCCCAG TGCTGCCAAG 
CGGCGCCGCA CGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060740.1
CDS	52..666
Translation	MGEAEVGGGGAAGDKGPGEAATSPAEETVVWSPEVEVCLFHAMLGHKPVGVNRHFHMICIRDKFSQNIGRQVPSKVIWDHLSTMYDMQALHESEILPFPNPERNFVLPEEIIQEVREGKVMIEEEMKEEMKEDVDPHNGADDVFSSSGSLGKASEKSSKDKEKNSSDLGCKEGADKRKRSRVTDKVLTANSNPSSPSAAKRRRT

Target ORF information:

RefSeq Version	NM_018270.6
Organism	Homo sapiens(human)
Definition	Homo sapiens MRG domain binding protein (MRGBP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018270.6

ORF Insert Sequence:

ATGGGAGAGG CCGAGGTGGG CGGCGGGGGC GCCGCAGGCG ACAAGGGCCC GGGGGAGGCG 
GCCACCAGCC CGGCGGAGGA GACAGTGGTG TGGAGCCCCG AGGTGGAGGT GTGCCTCTTC 
CACGCCATGC TGGGCCACAA GCCCGTCGGT GTGAACCGAC ACTTCCACAT GATTTGTATT 
CGGGACAAGT TCAGCCAGAA CATCGGGCGG CAGGTCCCAT CCAAGGTCAT CTGGGACCAT 
CTGAGCACCA TGTACGACAT GCAGGCGCTG CATGAGTCTG AGATTCTTCC ATTCCCGAAT 
CCAGAGAGGA ACTTCGTCCT TCCAGAAGAG ATCATTCAGG AGGTCCGAGA AGGAAAAGTG 
ATGATAGAAG AGGAGATGAA AGAGGAGATG AAGGAAGACG TGGACCCCCA CAATGGGGCT 
GACGATGTTT TTTCATCTTC AGGGAGTTTG GGGAAAGCAT CAGAAAAATC CAGCAAAGAC 
AAAGAGAAGA ACTCCTCAGA CTTGGGGTGC AAAGAAGGCG CAGACAAGCG GAAGCGCAGC 
CGGGTCACCG ACAAAGTCCT GACCGCAAAC AGCAACCCTT CCAGTCCCAG TGCTGCCAAG 
CGGCGCCGCA CGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MiR-137 Functions as a Tumor Suppressor in Pancreatic Cancer by Targeting MRGBP.
Journal of cellular biochemistry(2018 Jan)
Ding F,Zhang S,Gao S,Shang J,Li Y,Cui N,Zhao Q

MRGBP as a potential biomarker for the malignancy of pancreatic ductal adenocarcinoma.
Oncotarget8(38)64224-64236(2017 Sep)
Ding F,Zhang S,Gao S,Shang J,Li Y,Cui N,Zhao Q

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Structural Basis for Multi-specificity of MRG Domains.
Structure (London, England : 1993)23(6)1049-57(2015 Jun)
Xie T,Zmyslowski AM,Zhang Y,Radhakrishnan I

ANP32E is a histone chaperone that removes H2A.Z from chromatin.
Nature505(7485)648-53(2014 Jan)
Obri A,Ouararhni K,Papin C,Diebold ML,Padmanabhan K,Marek M,Stoll I,Roy L,Reilly PT,Mak TW,Dimitrov S,Romier C,Hamiche A

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MRGBP cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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