TMLHE cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TMLHE
Entrez Gene ID	55217
Full Name	trimethyllysine hydroxylase, epsilon
Synonyms	AUTSX6,BBOX2,TMLD,TMLH,TMLHED,XAP130
General protein information	Preferred Names trimethyllysine hydroxylase, epsilon Names trimethyllysine dioxygenase, mitochondrial TML hydroxylase TML-alpha-ketoglutarate dioxygenase butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 2 epsilon-trimethyllysine 2-oxoglutarate dioxygenase epsilon-trimethyllysine hydroxylase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq28
Summary	This gene encodes the protein trimethyllysine dioxygenase which is the first enzyme in the carnitine biosynthesis pathway. Carnitine play an essential role in the transport of activated fatty acids across the inner mitochondrial membrane. The encoded protein converts trimethyllysine into hydroxytrimethyllysine. A pseudogene of this gene is found on chromosome X. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010].
Disorder MIM:	300777
Disorder Html:	{Autism, susceptibility to, X-linked 6}, 300872 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_011531182.2	XP_011529484.1	trimethyllysine dioxygenase, mitochondrial isoform X1
NM_018196.4	NP_060666.1	trimethyllysine dioxygenase, mitochondrial isoform 1 precursor
NM_018196.3	NP_060666.1	trimethyllysine dioxygenase, mitochondrial isoform 1 precursor
XM_017029620.2	XP_016885109.1	trimethyllysine dioxygenase, mitochondrial isoform X2
XM_017029620.1	XP_016885109.1	trimethyllysine dioxygenase, mitochondrial isoform X2
NM_001184797.1	NP_001171726.1	trimethyllysine dioxygenase, mitochondrial isoform 2 precursor
XM_011531182.3	XP_011529484.1	trimethyllysine dioxygenase, mitochondrial isoform X1
NM_001184797.2	NP_001171726.1	trimethyllysine dioxygenase, mitochondrial isoform 2 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	TMLHE	NP_060666.1
Magnaporthe oryzae (rice blast fungus)	MGG_07454	XP_003711352.1
Neurospora crassa	NCU03802	XP_961191.2
Xenopus tropicalis (tropical clawed frog)	tmlhe	NP_001096300.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005447	XP_315450.4
Kluyveromyces lactis	KLLA0A10945g	XP_451476.1
Eremothecium gossypii	AGOS_AEL035W	NP_984826.2
Pan troglodytes (chimpanzee)	TMLHE	XP_521349.3
Bos taurus (cattle)	TMLHE	NP_001069532.1
Rattus norvegicus (Norway rat)	Tmlhe	NP_596878.2
Danio rerio (zebrafish)	tmlhe	XP_682831.3
Caenorhabditis elegans (roundworm)	gbh-2	NP_495793.2
	TMLHE	XP_001099674.1
Canis lupus familiaris (dog)	TMLHE	XP_853649.1
Mus musculus (house mouse)	Tmlhe	NP_620097.1
Gallus gallus (chicken)	TMLHE	NP_001012593.1
Drosophila melanogaster (fruit fly)	CG4335	NP_650886.1

Gene Ontology
Bibliography

Related articles in PubMed

Complex recombination with deletion in the F8 and duplication in the TMLHE mediated by int22h copies during early embryogenesis.
Chen C, Xie X, Wu X, Lu Y, Wang X, Wu W, Hu Y, Ding Q
Thrombosis and haemostasis117(8)1478-1485(2017 Jul)

Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function.
Floyd BJ, Wilkerson EM, Veling MT, Minogue CE, Xia C, Beebe ET, Wrobel RL, Cho H, Kremer LS, Alston CL, Gromek KA, Dolan BK, Ulbrich A, Stefely JA, Bohl SL, Werner KM, Jochem A, Westphall MS, Rensvold JW, Taylor RW, Prokisch H, Kim JP, Coon JJ, Pagliarini DJ
Molecular cell63(4)621-632(2016 Aug)

Analysis of the chromosome X exome in patients with autism spectrum disorders identified novel candidate genes, including TMLHE.
Nava C, Lamari F, H?ron D, Mignot C, Rastetter A, Keren B, Cohen D, Faudet A, Bouteiller D, Gilleron M, Jacquette A, Whalen S, Afenjar A, P?risse D, Laurent C, Dupuits C, Gautier C, G?rard M, Huguet G, Caillet S, Leheup B, Leboyer M, Gillberg C, Delorme R, Bourgeron T, Brice A, Depienne C
Translational psychiatry2e179(2012 Oct)

A common X-linked inborn error of carnitine biosynthesis may be a risk factor for nondysmorphic autism.
Celestino-Soper PB, Violante S, Crawford EL, Luo R, Lionel AC, Delaby E, Cai G, Sadikovic B, Lee K, Lo C, Gao K, Person RE, Moss TJ, German JR, Huang N, Shinawi M, Treadwell-Deering D, Szatmari P, Roberts W, Fernandez B, Schroer RJ, Stevenson RE, Buxbaum JD, Betancur C, Scherer SW, Sanders SJ, Geschwind DH, Sutcliffe JS, Hurles ME, Wanders RJ, Shaw CA, Leal SM, Cook EH Jr, Goin-Kochel RP, Vaz FM, Beaudet AL
Proceedings of the National Academy of Sciences of the United States of America109(21)7974-81(2012 May)

Use of array CGH to detect exonic copy number variants throughout the genome in autism families detects a novel deletion in TMLHE.
Celestino-Soper PB, Shaw CA, Sanders SJ, Li J, Murtha MT, Ercan-Sencicek AG, Davis L, Thomson S, Gambin T, Chinault AC, Ou Z, German JR, Milosavljevic A, Sutcliffe JS, Cook EH Jr, Stankiewicz P, State MW, Beaudet AL
Human molecular genetics20(22)4360-70(2011 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study found 3 mutations in TMLHE to be associated with autism spectrum disorder, c.229C>T/p.Arg77X, c.730G>C/p.Asp244His, and c.1107G>T/p.Glu369Asp.
Title: Analysis of the chromosome X exome in patients with autism spectrum disorders identified novel candidate genes, including TMLHE.

TMLHE deficiency is common in control males and was not significantly increased in frequency in probands from simplex autism families, however, it was 2.82-fold more frequent in probands from male-male multiplex autism families.
Title: A common X-linked inborn error of carnitine biosynthesis may be a risk factor for nondysmorphic autism.

Use of array CGH to detect exonic copy number variants throughout the genome in autism families detects a novel deletion in TMLHE.
Title: Use of array CGH to detect exonic copy number variants throughout the genome in autism families detects a novel deletion in TMLHE.

By 5' and 3' RACE, we identified and mapped two alternative 5' TMLH first exons and seven alternative 3'-splice variants.
Title: Functional characterization of the TMLH gene: promoter analysis, in situ hybridization, identification and mapping of alternative splicing variants.

C-terminal region of trimethyllysine hydroxylase, epsilon contains the main determinants for its enzymatic activity including a key H389 residue
Title: Functional analysis of TMLH variants and definition of domains required for catalytic activity and mitochondrial targeting.

The following TMLHE gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TMLHE cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09361	NM_001184797.2 Latest version!	Homo sapiens trimethyllysine hydroxylase, epsilon (TMLHE), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu21329	NM_018196.4 Latest version!	Homo sapiens trimethyllysine hydroxylase, epsilon (TMLHE), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$244.30 $349.00
OHu69186	XM_011531182.3 Latest version!	Homo sapiens trimethyllysine hydroxylase, epsilon (TMLHE), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu99360	XM_017029620.2 Latest version!	Homo sapiens trimethyllysine hydroxylase, epsilon (TMLHE), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu21329	NM_018196.3	Homo sapiens trimethyllysine hydroxylase, epsilon (TMLHE), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$244.30 $349.00
OHu99360	XM_017029620.1	Homo sapiens trimethyllysine hydroxylase, epsilon (TMLHE), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu69186	XM_011531182.2	Homo sapiens trimethyllysine hydroxylase, epsilon (TMLHE), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu09361	NM_001184797.1	Homo sapiens trimethyllysine hydroxylase, epsilon (TMLHE), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TMLHE ( NM_001184797.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001171726.1 Homo sapiens trimethyllysine hydroxylase, epsilon (TMLHE), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu09361
Clone ID Related Accession (Same CDS sequence)	NM_001184797.1 , NM_001184797.2
Accession Version	NM_001184797.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1131bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-10-12
Organism	Homo sapiens(human)
Product	trimethyllysine dioxygenase, mitochondrial isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB174485.1, DA323339.1 and BC025269.1. Transcript Variant: This variant (2) differs in the 3' UTR and coding region differences, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.572561.1, SRR1163655.118197.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTGGTACC ACAGATTGTC CCACCTACAC AGCAGGCTTC AGGACTTGCT GAAGGGAGGA 
GTCATATATC CGGCCCTTCC ACAGCCCAAC TTCAAAAGCT TACTTCCTTT AGCTGTCCAT 
TGGCACCATA CAGCCTCCAA GTCTCTGACT TGTGCTTGGC AGCAACATGA AGATCATTTT 
GAGCTGAAAT ATGCTAATAC CGTGATGCGC TTTGATTACG TCTGGCTTCG AGACCACTGC 
CGCTCAGCAT CGTGCTACAA CTCTAAGACT CACCAGCGCA GCCTGGATAC TGCCAGTGTG 
GATTTATGTA TCAAGCCAAA GACCATTCGT CTGGATGAGA CCACACTCTT TTTCACTTGG 
CCAGATGGTC ATGTGACTAA ATATGATTTG AATTGGCTGG TGAAAAACAG CTATGAAGGG 
CAGAAACAAA AAGTCATCCA GCCTAGAATA CTATGGAATG CTGAAATCTA CCAGCAAGCC 
CAAGTTCCAT CGGTAGATTG CCAGAGCTTC TTAGAAACCA ACGAGGGACT GAAGAAGTTT 
CTGCAAAACT TTCTGCTCTA TGGAATTGCA TTCGTAGAAA ATGTCCCTCC CACTCAAGAG 
CACACAGAGA AGTTGGCAGA AAGGATCAGC TTAATCAGAG AAACCATTTA TGGGAGGATG 
TGGTATTTCA CTTCAGACTT CTCCAGAGGT GACACTGCGT ACACCAAGCT AGCTCTGGAT 
CGGCACACTG ACACTACCTA TTTTCAAGAG CCCTGTGGCA TTCAAGTGTT TCATTGTCTT 
AAACATGAAG GAACTGGTGG CAGGACACTG CTAGTAGATG GATTCTATGC AGCAGAACAG 
GTACTTCAAA AGGCACCTGA GGAATTTGAA CTCCTCAGTA AAGTGCCATT GAAGCATGAA 
TATATTGAAG ATGTTGGAGA ATGTCACAAC CACATGATTG GGATTGGGCC AGTCTTAAAT 
ATCTACCCAT GGAATAAAGA GCTGTATTTG ATCAGATTAT TCAAAGAAAA ACAAAACACG 
GTCAACAGGC AGTGGAACTC CTCACTCCAA TGTGATATTC CTGAGAGAAT ATTGACTTAT 
CGTCACTTCG TCTCTGGGAC AAGTATTGAA CATAGGGGAA GCCTTATATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001171726.1
CDS	172..1302
Translation	MWYHRLSHLHSRLQDLLKGGVIYPALPQPNFKSLLPLAVHWHHTASKSLTCAWQQHEDHFELKYANTVMRFDYVWLRDHCRSASCYNSKTHQRSLDTASVDLCIKPKTIRLDETTLFFTWPDGHVTKYDLNWLVKNSYEGQKQKVIQPRILWNAEIYQQAQVPSVDCQSFLETNEGLKKFLQNFLLYGIAFVENVPPTQEHTEKLAERISLIRETIYGRMWYFTSDFSRGDTAYTKLALDRHTDTTYFQEPCGIQVFHCLKHEGTGGRTLLVDGFYAAEQVLQKAPEEFELLSKVPLKHEYIEDVGECHNHMIGIGPVLNIYPWNKELYLIRLFKEKQNTVNRQWNSSLQCDIPERILTYRHFVSGTSIEHRGSLI

Target ORF information:

RefSeq Version	NM_001184797.1
Organism	Homo sapiens(human)
Definition	Homo sapiens trimethyllysine hydroxylase, epsilon (TMLHE), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001184797.1

ORF Insert Sequence:

ATGTGGTACC ACAGATTGTC CCACCTACAC AGCAGGCTTC AGGACTTGCT GAAGGGAGGA 
GTCATATATC CGGCCCTTCC ACAGCCCAAC TTCAAAAGCT TACTTCCTTT AGCTGTCCAT 
TGGCACCATA CAGCCTCCAA GTCTCTGACT TGTGCTTGGC AGCAACATGA AGATCATTTT 
GAGCTGAAAT ATGCTAATAC CGTGATGCGC TTTGATTACG TCTGGCTTCG AGACCACTGC 
CGCTCAGCAT CGTGCTACAA CTCTAAGACT CACCAGCGCA GCCTGGATAC TGCCAGTGTG 
GATTTATGTA TCAAGCCAAA GACCATTCGT CTGGATGAGA CCACACTCTT TTTCACTTGG 
CCAGATGGTC ATGTGACTAA ATATGATTTG AATTGGCTGG TGAAAAACAG CTATGAAGGG 
CAGAAACAAA AAGTCATCCA GCCTAGAATA CTATGGAATG CTGAAATCTA CCAGCAAGCC 
CAAGTTCCAT CGGTAGATTG CCAGAGCTTC TTAGAAACCA ACGAGGGACT GAAGAAGTTT 
CTGCAAAACT TTCTGCTCTA TGGAATTGCA TTCGTAGAAA ATGTCCCTCC CACTCAAGAG 
CACACAGAGA AGTTGGCAGA AAGGATCAGC TTAATCAGAG AAACCATTTA TGGGAGGATG 
TGGTATTTCA CTTCAGACTT CTCCAGAGGT GACACTGCGT ACACCAAGCT AGCTCTGGAT 
CGGCACACTG ACACTACCTA TTTTCAAGAG CCCTGTGGCA TTCAAGTGTT TCATTGTCTT 
AAACATGAAG GAACTGGTGG CAGGACACTG CTAGTAGATG GATTCTATGC AGCAGAACAG 
GTACTTCAAA AGGCACCTGA GGAATTTGAA CTCCTCAGTA AAGTGCCATT GAAGCATGAA 
TATATTGAAG ATGTTGGAGA ATGTCACAAC CACATGATTG GGATTGGGCC AGTCTTAAAT 
ATCTACCCAT GGAATAAAGA GCTGTATTTG ATCAGATTAT TCAAAGAAAA ACAAAACACG 
GTCAACAGGC AGTGGAACTC CTCACTCCAA TGTGATATTC CTGAGAGAAT ATTGACTTAT 
CGTCACTTCG TCTCTGGGAC AAGTATTGAA CATAGGGGAA GCCTTATATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMLHE ( NM_001184797.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001171726.1 Homo sapiens trimethyllysine hydroxylase, epsilon (TMLHE), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu09361
Clone ID Related Accession (Same CDS sequence)	NM_001184797.1 , NM_001184797.2
Accession Version	NM_001184797.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1131bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Homo sapiens(human)
Product	trimethyllysine dioxygenase, mitochondrial isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB174485.1, DA323339.1 and BC025269.1. On May 31, 2019 this sequence version replaced NM_001184797.1. Transcript Variant: This variant (2) differs in the 3' UTR and coding region differences, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.572561.1, BC025269.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTGGTACC ACAGATTGTC CCACCTACAC AGCAGGCTTC AGGACTTGCT GAAGGGAGGA 
GTCATATATC CGGCCCTTCC ACAGCCCAAC TTCAAAAGCT TACTTCCTTT AGCTGTCCAT 
TGGCACCATA CAGCCTCCAA GTCTCTGACT TGTGCTTGGC AGCAACATGA AGATCATTTT 
GAGCTGAAAT ATGCTAATAC CGTGATGCGC TTTGATTACG TCTGGCTTCG AGACCACTGC 
CGCTCAGCAT CGTGCTACAA CTCTAAGACT CACCAGCGCA GCCTGGATAC TGCCAGTGTG 
GATTTATGTA TCAAGCCAAA GACCATTCGT CTGGATGAGA CCACACTCTT TTTCACTTGG 
CCAGATGGTC ATGTGACTAA ATATGATTTG AATTGGCTGG TGAAAAACAG CTATGAAGGG 
CAGAAACAAA AAGTCATCCA GCCTAGAATA CTATGGAATG CTGAAATCTA CCAGCAAGCC 
CAAGTTCCAT CGGTAGATTG CCAGAGCTTC TTAGAAACCA ACGAGGGACT GAAGAAGTTT 
CTGCAAAACT TTCTGCTCTA TGGAATTGCA TTCGTAGAAA ATGTCCCTCC CACTCAAGAG 
CACACAGAGA AGTTGGCAGA AAGGATCAGC TTAATCAGAG AAACCATTTA TGGGAGGATG 
TGGTATTTCA CTTCAGACTT CTCCAGAGGT GACACTGCGT ACACCAAGCT AGCTCTGGAT 
CGGCACACTG ACACTACCTA TTTTCAAGAG CCCTGTGGCA TTCAAGTGTT TCATTGTCTT 
AAACATGAAG GAACTGGTGG CAGGACACTG CTAGTAGATG GATTCTATGC AGCAGAACAG 
GTACTTCAAA AGGCACCTGA GGAATTTGAA CTCCTCAGTA AAGTGCCATT GAAGCATGAA 
TATATTGAAG ATGTTGGAGA ATGTCACAAC CACATGATTG GGATTGGGCC AGTCTTAAAT 
ATCTACCCAT GGAATAAAGA GCTGTATTTG ATCAGATTAT TCAAAGAAAA ACAAAACACG 
GTCAACAGGC AGTGGAACTC CTCACTCCAA TGTGATATTC CTGAGAGAAT ATTGACTTAT 
CGTCACTTCG TCTCTGGGAC AAGTATTGAA CATAGGGGAA GCCTTATATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001171726.1
CDS	163..1293
Translation	MWYHRLSHLHSRLQDLLKGGVIYPALPQPNFKSLLPLAVHWHHTASKSLTCAWQQHEDHFELKYANTVMRFDYVWLRDHCRSASCYNSKTHQRSLDTASVDLCIKPKTIRLDETTLFFTWPDGHVTKYDLNWLVKNSYEGQKQKVIQPRILWNAEIYQQAQVPSVDCQSFLETNEGLKKFLQNFLLYGIAFVENVPPTQEHTEKLAERISLIRETIYGRMWYFTSDFSRGDTAYTKLALDRHTDTTYFQEPCGIQVFHCLKHEGTGGRTLLVDGFYAAEQVLQKAPEEFELLSKVPLKHEYIEDVGECHNHMIGIGPVLNIYPWNKELYLIRLFKEKQNTVNRQWNSSLQCDIPERILTYRHFVSGTSIEHRGSLI

Target ORF information:

RefSeq Version	NM_001184797.2
Organism	Homo sapiens(human)
Definition	Homo sapiens trimethyllysine hydroxylase, epsilon (TMLHE), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001184797.2

ORF Insert Sequence:

ATGTGGTACC ACAGATTGTC CCACCTACAC AGCAGGCTTC AGGACTTGCT GAAGGGAGGA 
GTCATATATC CGGCCCTTCC ACAGCCCAAC TTCAAAAGCT TACTTCCTTT AGCTGTCCAT 
TGGCACCATA CAGCCTCCAA GTCTCTGACT TGTGCTTGGC AGCAACATGA AGATCATTTT 
GAGCTGAAAT ATGCTAATAC CGTGATGCGC TTTGATTACG TCTGGCTTCG AGACCACTGC 
CGCTCAGCAT CGTGCTACAA CTCTAAGACT CACCAGCGCA GCCTGGATAC TGCCAGTGTG 
GATTTATGTA TCAAGCCAAA GACCATTCGT CTGGATGAGA CCACACTCTT TTTCACTTGG 
CCAGATGGTC ATGTGACTAA ATATGATTTG AATTGGCTGG TGAAAAACAG CTATGAAGGG 
CAGAAACAAA AAGTCATCCA GCCTAGAATA CTATGGAATG CTGAAATCTA CCAGCAAGCC 
CAAGTTCCAT CGGTAGATTG CCAGAGCTTC TTAGAAACCA ACGAGGGACT GAAGAAGTTT 
CTGCAAAACT TTCTGCTCTA TGGAATTGCA TTCGTAGAAA ATGTCCCTCC CACTCAAGAG 
CACACAGAGA AGTTGGCAGA AAGGATCAGC TTAATCAGAG AAACCATTTA TGGGAGGATG 
TGGTATTTCA CTTCAGACTT CTCCAGAGGT GACACTGCGT ACACCAAGCT AGCTCTGGAT 
CGGCACACTG ACACTACCTA TTTTCAAGAG CCCTGTGGCA TTCAAGTGTT TCATTGTCTT 
AAACATGAAG GAACTGGTGG CAGGACACTG CTAGTAGATG GATTCTATGC AGCAGAACAG 
GTACTTCAAA AGGCACCTGA GGAATTTGAA CTCCTCAGTA AAGTGCCATT GAAGCATGAA 
TATATTGAAG ATGTTGGAGA ATGTCACAAC CACATGATTG GGATTGGGCC AGTCTTAAAT 
ATCTACCCAT GGAATAAAGA GCTGTATTTG ATCAGATTAT TCAAAGAAAA ACAAAACACG 
GTCAACAGGC AGTGGAACTC CTCACTCCAA TGTGATATTC CTGAGAGAAT ATTGACTTAT 
CGTCACTTCG TCTCTGGGAC AAGTATTGAA CATAGGGGAA GCCTTATATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMLHE ( NM_018196.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_060666.1 Homo sapiens trimethyllysine hydroxylase, epsilon (TMLHE), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21329
Clone ID Related Accession (Same CDS sequence)	NM_018196.4 , NM_018196.3
Accession Version	NM_018196.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1266bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	trimethyllysine dioxygenase, mitochondrial isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB174485.1, AK001589.1 and BX571846.3. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_018196.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.2538.1, SRR1803611.712.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology MANE Ensembl match :: ENST00000334398.8/ ENSP00000335261.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTGGTACC ACAGATTGTC CCACCTACAC AGCAGGCTTC AGGACTTGCT GAAGGGAGGA 
GTCATATATC CGGCCCTTCC ACAGCCCAAC TTCAAAAGCT TACTTCCTTT AGCTGTCCAT 
TGGCACCATA CAGCCTCCAA GTCTCTGACT TGTGCTTGGC AGCAACATGA AGATCATTTT 
GAGCTGAAAT ATGCTAATAC CGTGATGCGC TTTGATTACG TCTGGCTTCG AGACCACTGC 
CGCTCAGCAT CGTGCTACAA CTCTAAGACT CACCAGCGCA GCCTGGATAC TGCCAGTGTG 
GATTTATGTA TCAAGCCAAA GACCATTCGT CTGGATGAGA CCACACTCTT TTTCACTTGG 
CCAGATGGTC ATGTGACTAA ATATGATTTG AATTGGCTGG TGAAAAACAG CTATGAAGGG 
CAGAAACAAA AAGTCATCCA GCCTAGAATA CTATGGAATG CTGAAATCTA CCAGCAAGCC 
CAAGTTCCAT CGGTAGATTG CCAGAGCTTC TTAGAAACCA ACGAGGGACT GAAGAAGTTT 
CTGCAAAACT TTCTGCTCTA TGGAATTGCA TTCGTAGAAA ATGTCCCTCC CACTCAAGAG 
CACACAGAGA AGTTGGCAGA AAGGATCAGC TTAATCAGAG AAACCATTTA TGGGAGGATG 
TGGTATTTCA CTTCAGACTT CTCCAGAGGT GACACTGCGT ACACCAAGCT AGCTCTGGAT 
CGGCACACTG ACACTACCTA TTTTCAAGAG CCCTGTGGCA TTCAAGTGTT TCATTGTCTT 
AAACATGAAG GAACTGGTGG CAGGACACTG CTAGTAGATG GATTCTATGC AGCAGAACAG 
GTACTTCAAA AGGCACCTGA GGAATTTGAA CTCCTCAGTA AAGTGCCATT GAAGCATGAA 
TATATTGAAG ATGTTGGAGA ATGTCACAAC CACATGATTG GGATTGGGCC AGTCTTAAAT 
ATCTACCCAT GGAATAAAGA GCTGTATTTG ATCAGGTACA ACAACTATGA CCGGGCTGTC 
ATCAATACCG TTCCTTATGA TGTCGTCCAT CGCTGGTATA CAGCACACCG GACTCTAACG 
ATAGAGTTGA GGAGACCTGA GAATGAGTTT TGGGTCAAAC TAAAGCCTGG CAGGGTCCTA 
TTTATAGACA ACTGGCGTGT CCTACATGGC AGGGAATGCT TCACTGGCTA CCGCCAACTG 
TGTGGCTGCT ATTTAACAAG AGATGATGTA TTAAACACTG CTCGCCTCTT GGGGCTTCAG 
GCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060666.1
CDS	163..1428
Translation	MWYHRLSHLHSRLQDLLKGGVIYPALPQPNFKSLLPLAVHWHHTASKSLTCAWQQHEDHFELKYANTVMRFDYVWLRDHCRSASCYNSKTHQRSLDTASVDLCIKPKTIRLDETTLFFTWPDGHVTKYDLNWLVKNSYEGQKQKVIQPRILWNAEIYQQAQVPSVDCQSFLETNEGLKKFLQNFLLYGIAFVENVPPTQEHTEKLAERISLIRETIYGRMWYFTSDFSRGDTAYTKLALDRHTDTTYFQEPCGIQVFHCLKHEGTGGRTLLVDGFYAAEQVLQKAPEEFELLSKVPLKHEYIEDVGECHNHMIGIGPVLNIYPWNKELYLIRYNNYDRAVINTVPYDVVHRWYTAHRTLTIELRRPENEFWVKLKPGRVLFIDNWRVLHGRECFTGYRQLCGCYLTRDDVLNTARLLGLQA

Target ORF information:

RefSeq Version	NM_018196.4
Organism	Homo sapiens(human)
Definition	Homo sapiens trimethyllysine hydroxylase, epsilon (TMLHE), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018196.4

ORF Insert Sequence:

ATGTGGTACC ACAGATTGTC CCACCTACAC AGCAGGCTTC AGGACTTGCT GAAGGGAGGA 
GTCATATATC CGGCCCTTCC ACAGCCCAAC TTCAAAAGCT TACTTCCTTT AGCTGTCCAT 
TGGCACCATA CAGCCTCCAA GTCTCTGACT TGTGCTTGGC AGCAACATGA AGATCATTTT 
GAGCTGAAAT ATGCTAATAC CGTGATGCGC TTTGATTACG TCTGGCTTCG AGACCACTGC 
CGCTCAGCAT CGTGCTACAA CTCTAAGACT CACCAGCGCA GCCTGGATAC TGCCAGTGTG 
GATTTATGTA TCAAGCCAAA GACCATTCGT CTGGATGAGA CCACACTCTT TTTCACTTGG 
CCAGATGGTC ATGTGACTAA ATATGATTTG AATTGGCTGG TGAAAAACAG CTATGAAGGG 
CAGAAACAAA AAGTCATCCA GCCTAGAATA CTATGGAATG CTGAAATCTA CCAGCAAGCC 
CAAGTTCCAT CGGTAGATTG CCAGAGCTTC TTAGAAACCA ACGAGGGACT GAAGAAGTTT 
CTGCAAAACT TTCTGCTCTA TGGAATTGCA TTCGTAGAAA ATGTCCCTCC CACTCAAGAG 
CACACAGAGA AGTTGGCAGA AAGGATCAGC TTAATCAGAG AAACCATTTA TGGGAGGATG 
TGGTATTTCA CTTCAGACTT CTCCAGAGGT GACACTGCGT ACACCAAGCT AGCTCTGGAT 
CGGCACACTG ACACTACCTA TTTTCAAGAG CCCTGTGGCA TTCAAGTGTT TCATTGTCTT 
AAACATGAAG GAACTGGTGG CAGGACACTG CTAGTAGATG GATTCTATGC AGCAGAACAG 
GTACTTCAAA AGGCACCTGA GGAATTTGAA CTCCTCAGTA AAGTGCCATT GAAGCATGAA 
TATATTGAAG ATGTTGGAGA ATGTCACAAC CACATGATTG GGATTGGGCC AGTCTTAAAT 
ATCTACCCAT GGAATAAAGA GCTGTATTTG ATCAGGTACA ACAACTATGA CCGGGCTGTC 
ATCAATACCG TTCCTTATGA TGTCGTCCAT CGCTGGTATA CAGCACACCG GACTCTAACG 
ATAGAGTTGA GGAGACCTGA GAATGAGTTT TGGGTCAAAC TAAAGCCTGG CAGGGTCCTA 
TTTATAGACA ACTGGCGTGT CCTACATGGC AGGGAATGCT TCACTGGCTA CCGCCAACTG 
TGTGGCTGCT ATTTAACAAG AGATGATGTA TTAAACACTG CTCGCCTCTT GGGGCTTCAG 
GCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMLHE ( NM_018196.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_060666.1 Homo sapiens trimethyllysine hydroxylase, epsilon (TMLHE), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21329
Clone ID Related Accession (Same CDS sequence)	NM_018196.4 , NM_018196.3
Accession Version	NM_018196.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1266bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	trimethyllysine dioxygenase, mitochondrial isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB174485.1, AK001589.1 and BX571846.3. This sequence is a reference standard in the RefSeqGene project. On May 20, 2010 this sequence version replaced NM_018196.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.2538.1, SRR1803611.712.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTGGTACC ACAGATTGTC CCACCTACAC AGCAGGCTTC AGGACTTGCT GAAGGGAGGA 
GTCATATATC CGGCCCTTCC ACAGCCCAAC TTCAAAAGCT TACTTCCTTT AGCTGTCCAT 
TGGCACCATA CAGCCTCCAA GTCTCTGACT TGTGCTTGGC AGCAACATGA AGATCATTTT 
GAGCTGAAAT ATGCTAATAC CGTGATGCGC TTTGATTACG TCTGGCTTCG AGACCACTGC 
CGCTCAGCAT CGTGCTACAA CTCTAAGACT CACCAGCGCA GCCTGGATAC TGCCAGTGTG 
GATTTATGTA TCAAGCCAAA GACCATTCGT CTGGATGAGA CCACACTCTT TTTCACTTGG 
CCAGATGGTC ATGTGACTAA ATATGATTTG AATTGGCTGG TGAAAAACAG CTATGAAGGG 
CAGAAACAAA AAGTCATCCA GCCTAGAATA CTATGGAATG CTGAAATCTA CCAGCAAGCC 
CAAGTTCCAT CGGTAGATTG CCAGAGCTTC TTAGAAACCA ACGAGGGACT GAAGAAGTTT 
CTGCAAAACT TTCTGCTCTA TGGAATTGCA TTCGTAGAAA ATGTCCCTCC CACTCAAGAG 
CACACAGAGA AGTTGGCAGA AAGGATCAGC TTAATCAGAG AAACCATTTA TGGGAGGATG 
TGGTATTTCA CTTCAGACTT CTCCAGAGGT GACACTGCGT ACACCAAGCT AGCTCTGGAT 
CGGCACACTG ACACTACCTA TTTTCAAGAG CCCTGTGGCA TTCAAGTGTT TCATTGTCTT 
AAACATGAAG GAACTGGTGG CAGGACACTG CTAGTAGATG GATTCTATGC AGCAGAACAG 
GTACTTCAAA AGGCACCTGA GGAATTTGAA CTCCTCAGTA AAGTGCCATT GAAGCATGAA 
TATATTGAAG ATGTTGGAGA ATGTCACAAC CACATGATTG GGATTGGGCC AGTCTTAAAT 
ATCTACCCAT GGAATAAAGA GCTGTATTTG ATCAGGTACA ACAACTATGA CCGGGCTGTC 
ATCAATACCG TTCCTTATGA TGTCGTCCAT CGCTGGTATA CAGCACACCG GACTCTAACG 
ATAGAGTTGA GGAGACCTGA GAATGAGTTT TGGGTCAAAC TAAAGCCTGG CAGGGTCCTA 
TTTATAGACA ACTGGCGTGT CCTACATGGC AGGGAATGCT TCACTGGCTA CCGCCAACTG 
TGTGGCTGCT ATTTAACAAG AGATGATGTA TTAAACACTG CTCGCCTCTT GGGGCTTCAG 
GCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060666.1
CDS	172..1437
Translation	MWYHRLSHLHSRLQDLLKGGVIYPALPQPNFKSLLPLAVHWHHTASKSLTCAWQQHEDHFELKYANTVMRFDYVWLRDHCRSASCYNSKTHQRSLDTASVDLCIKPKTIRLDETTLFFTWPDGHVTKYDLNWLVKNSYEGQKQKVIQPRILWNAEIYQQAQVPSVDCQSFLETNEGLKKFLQNFLLYGIAFVENVPPTQEHTEKLAERISLIRETIYGRMWYFTSDFSRGDTAYTKLALDRHTDTTYFQEPCGIQVFHCLKHEGTGGRTLLVDGFYAAEQVLQKAPEEFELLSKVPLKHEYIEDVGECHNHMIGIGPVLNIYPWNKELYLIRYNNYDRAVINTVPYDVVHRWYTAHRTLTIELRRPENEFWVKLKPGRVLFIDNWRVLHGRECFTGYRQLCGCYLTRDDVLNTARLLGLQA

Target ORF information:

RefSeq Version	NM_018196.3
Organism	Homo sapiens(human)
Definition	Homo sapiens trimethyllysine hydroxylase, epsilon (TMLHE), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018196.3

ORF Insert Sequence:

ATGTGGTACC ACAGATTGTC CCACCTACAC AGCAGGCTTC AGGACTTGCT GAAGGGAGGA 
GTCATATATC CGGCCCTTCC ACAGCCCAAC TTCAAAAGCT TACTTCCTTT AGCTGTCCAT 
TGGCACCATA CAGCCTCCAA GTCTCTGACT TGTGCTTGGC AGCAACATGA AGATCATTTT 
GAGCTGAAAT ATGCTAATAC CGTGATGCGC TTTGATTACG TCTGGCTTCG AGACCACTGC 
CGCTCAGCAT CGTGCTACAA CTCTAAGACT CACCAGCGCA GCCTGGATAC TGCCAGTGTG 
GATTTATGTA TCAAGCCAAA GACCATTCGT CTGGATGAGA CCACACTCTT TTTCACTTGG 
CCAGATGGTC ATGTGACTAA ATATGATTTG AATTGGCTGG TGAAAAACAG CTATGAAGGG 
CAGAAACAAA AAGTCATCCA GCCTAGAATA CTATGGAATG CTGAAATCTA CCAGCAAGCC 
CAAGTTCCAT CGGTAGATTG CCAGAGCTTC TTAGAAACCA ACGAGGGACT GAAGAAGTTT 
CTGCAAAACT TTCTGCTCTA TGGAATTGCA TTCGTAGAAA ATGTCCCTCC CACTCAAGAG 
CACACAGAGA AGTTGGCAGA AAGGATCAGC TTAATCAGAG AAACCATTTA TGGGAGGATG 
TGGTATTTCA CTTCAGACTT CTCCAGAGGT GACACTGCGT ACACCAAGCT AGCTCTGGAT 
CGGCACACTG ACACTACCTA TTTTCAAGAG CCCTGTGGCA TTCAAGTGTT TCATTGTCTT 
AAACATGAAG GAACTGGTGG CAGGACACTG CTAGTAGATG GATTCTATGC AGCAGAACAG 
GTACTTCAAA AGGCACCTGA GGAATTTGAA CTCCTCAGTA AAGTGCCATT GAAGCATGAA 
TATATTGAAG ATGTTGGAGA ATGTCACAAC CACATGATTG GGATTGGGCC AGTCTTAAAT 
ATCTACCCAT GGAATAAAGA GCTGTATTTG ATCAGGTACA ACAACTATGA CCGGGCTGTC 
ATCAATACCG TTCCTTATGA TGTCGTCCAT CGCTGGTATA CAGCACACCG GACTCTAACG 
ATAGAGTTGA GGAGACCTGA GAATGAGTTT TGGGTCAAAC TAAAGCCTGG CAGGGTCCTA 
TTTATAGACA ACTGGCGTGT CCTACATGGC AGGGAATGCT TCACTGGCTA CCGCCAACTG 
TGTGGCTGCT ATTTAACAAG AGATGATGTA TTAAACACTG CTCGCCTCTT GGGGCTTCAG 
GCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMLHE ( XM_011531182.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011529484.1 Homo sapiens trimethyllysine hydroxylase, epsilon (TMLHE), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu69186
Clone ID Related Accession (Same CDS sequence)	XM_011531182.2 , XM_011531182.3
Accession Version	XM_011531182.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1113bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	trimethyllysine dioxygenase, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011531182.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGGGTTA TAAAAGAGAT GAATCAAGAG CTGAAATATG CTAATACCGT GATGCGCTTT 
GATTACGTCT GGCTTCGAGA CCACTGCCGC TCAGCATCGT GCTACAACTC TAAGACTCAC 
CAGCGCAGCC TGGATACTGC CAGTGTGGAT TTATGTATCA AGCCAAAGAC CATTCGTCTG 
GATGAGACCA CACTCTTTTT CACTTGGCCA GATGGTCATG TGACTAAATA TGATTTGAAT 
TGGCTGGTGA AAAACAGCTA TGAAGGGCAG AAACAAAAAG TCATCCAGCC TAGAATACTA 
TGGAATGCTG AAATCTACCA GCAAGCCCAA GTTCCATCGG TAGATTGCCA GAGCTTCTTA 
GAAACCAACG AGGGACTGAA GAAGTTTCTG CAAAACTTTC TGCTCTATGG AATTGCATTC 
GTAGAAAATG TCCCTCCCAC TCAAGAGCAC ACAGAGAAGT TGGCAGAAAG GATCAGCTTA 
ATCAGAGAAA CCATTTATGG GAGGATGTGG TATTTCACTT CAGACTTCTC CAGAGGTGAC 
ACTGCGTACA CCAAGCTAGC TCTGGATCGG CACACTGACA CTACCTATTT TCAAGAGCCC 
TGTGGCATTC AAGTGTTTCA TTGTCTTAAA CATGAAGGAA CTGGTGGCAG GACACTGCTA 
GTAGATGGAT TCTATGCAGC AGAACAGGTA CTTCAAAAGG CACCTGAGGA ATTTGAACTC 
CTCAGTAAAG TGCCATTGAA GCATGAATAT ATTGAAGATG TTGGAGAATG TCACAACCAC 
ATGATTGGGA TTGGGCCAGT CTTAAATATC TACCCATGGA ATAAAGAGCT GTATTTGATC 
AGGTACAACA ACTATGACCG GGCTGTCATC AATACCGTTC CTTATGATGT CGTCCATCGC 
TGGTATACAG CACACCGGAC TCTAACGATA GAGTTGAGGA GACCTGAGAA TGAGTTTTGG 
GTCAAACTAA AGCCTGGCAG GGTCCTATTT ATAGACAACT GGCGTGTCCT ACATGGCAGG 
GAATGCTTCA CTGGCTACCG CCAACTGTGT GGCTGCTATT TAACAAGAGA TGATGTATTA 
AACACTGCTC GCCTCTTGGG GCTTCAGGCT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011529484.1
CDS	193..1305
Translation	MWVIKEMNQELKYANTVMRFDYVWLRDHCRSASCYNSKTHQRSLDTASVDLCIKPKTIRLDETTLFFTWPDGHVTKYDLNWLVKNSYEGQKQKVIQPRILWNAEIYQQAQVPSVDCQSFLETNEGLKKFLQNFLLYGIAFVENVPPTQEHTEKLAERISLIRETIYGRMWYFTSDFSRGDTAYTKLALDRHTDTTYFQEPCGIQVFHCLKHEGTGGRTLLVDGFYAAEQVLQKAPEEFELLSKVPLKHEYIEDVGECHNHMIGIGPVLNIYPWNKELYLIRYNNYDRAVINTVPYDVVHRWYTAHRTLTIELRRPENEFWVKLKPGRVLFIDNWRVLHGRECFTGYRQLCGCYLTRDDVLNTARLLGLQA

Target ORF information:

RefSeq Version	XM_011531182.2
Organism	Homo sapiens(human)
Definition	Homo sapiens trimethyllysine hydroxylase, epsilon (TMLHE), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011531182.2

ORF Insert Sequence:

ATGTGGGTTA TAAAAGAGAT GAATCAAGAG CTGAAATATG CTAATACCGT GATGCGCTTT 
GATTACGTCT GGCTTCGAGA CCACTGCCGC TCAGCATCGT GCTACAACTC TAAGACTCAC 
CAGCGCAGCC TGGATACTGC CAGTGTGGAT TTATGTATCA AGCCAAAGAC CATTCGTCTG 
GATGAGACCA CACTCTTTTT CACTTGGCCA GATGGTCATG TGACTAAATA TGATTTGAAT 
TGGCTGGTGA AAAACAGCTA TGAAGGGCAG AAACAAAAAG TCATCCAGCC TAGAATACTA 
TGGAATGCTG AAATCTACCA GCAAGCCCAA GTTCCATCGG TAGATTGCCA GAGCTTCTTA 
GAAACCAACG AGGGACTGAA GAAGTTTCTG CAAAACTTTC TGCTCTATGG AATTGCATTC 
GTAGAAAATG TCCCTCCCAC TCAAGAGCAC ACAGAGAAGT TGGCAGAAAG GATCAGCTTA 
ATCAGAGAAA CCATTTATGG GAGGATGTGG TATTTCACTT CAGACTTCTC CAGAGGTGAC 
ACTGCGTACA CCAAGCTAGC TCTGGATCGG CACACTGACA CTACCTATTT TCAAGAGCCC 
TGTGGCATTC AAGTGTTTCA TTGTCTTAAA CATGAAGGAA CTGGTGGCAG GACACTGCTA 
GTAGATGGAT TCTATGCAGC AGAACAGGTA CTTCAAAAGG CACCTGAGGA ATTTGAACTC 
CTCAGTAAAG TGCCATTGAA GCATGAATAT ATTGAAGATG TTGGAGAATG TCACAACCAC 
ATGATTGGGA TTGGGCCAGT CTTAAATATC TACCCATGGA ATAAAGAGCT GTATTTGATC 
AGGTACAACA ACTATGACCG GGCTGTCATC AATACCGTTC CTTATGATGT CGTCCATCGC 
TGGTATACAG CACACCGGAC TCTAACGATA GAGTTGAGGA GACCTGAGAA TGAGTTTTGG 
GTCAAACTAA AGCCTGGCAG GGTCCTATTT ATAGACAACT GGCGTGTCCT ACATGGCAGG 
GAATGCTTCA CTGGCTACCG CCAACTGTGT GGCTGCTATT TAACAAGAGA TGATGTATTA 
AACACTGCTC GCCTCTTGGG GCTTCAGGCT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMLHE ( XM_011531182.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011529484.1 Homo sapiens trimethyllysine hydroxylase, epsilon (TMLHE), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu69186
Clone ID Related Accession (Same CDS sequence)	XM_011531182.2 , XM_011531182.3
Accession Version	XM_011531182.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1113bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	trimethyllysine dioxygenase, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011531182.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGGGTTA TAAAAGAGAT GAATCAAGAG CTGAAATATG CTAATACCGT GATGCGCTTT 
GATTACGTCT GGCTTCGAGA CCACTGCCGC TCAGCATCGT GCTACAACTC TAAGACTCAC 
CAGCGCAGCC TGGATACTGC CAGTGTGGAT TTATGTATCA AGCCAAAGAC CATTCGTCTG 
GATGAGACCA CACTCTTTTT CACTTGGCCA GATGGTCATG TGACTAAATA TGATTTGAAT 
TGGCTGGTGA AAAACAGCTA TGAAGGGCAG AAACAAAAAG TCATCCAGCC TAGAATACTA 
TGGAATGCTG AAATCTACCA GCAAGCCCAA GTTCCATCGG TAGATTGCCA GAGCTTCTTA 
GAAACCAACG AGGGACTGAA GAAGTTTCTG CAAAACTTTC TGCTCTATGG AATTGCATTC 
GTAGAAAATG TCCCTCCCAC TCAAGAGCAC ACAGAGAAGT TGGCAGAAAG GATCAGCTTA 
ATCAGAGAAA CCATTTATGG GAGGATGTGG TATTTCACTT CAGACTTCTC CAGAGGTGAC 
ACTGCGTACA CCAAGCTAGC TCTGGATCGG CACACTGACA CTACCTATTT TCAAGAGCCC 
TGTGGCATTC AAGTGTTTCA TTGTCTTAAA CATGAAGGAA CTGGTGGCAG GACACTGCTA 
GTAGATGGAT TCTATGCAGC AGAACAGGTA CTTCAAAAGG CACCTGAGGA ATTTGAACTC 
CTCAGTAAAG TGCCATTGAA GCATGAATAT ATTGAAGATG TTGGAGAATG TCACAACCAC 
ATGATTGGGA TTGGGCCAGT CTTAAATATC TACCCATGGA ATAAAGAGCT GTATTTGATC 
AGGTACAACA ACTATGACCG GGCTGTCATC AATACCGTTC CTTATGATGT CGTCCATCGC 
TGGTATACAG CACACCGGAC TCTAACGATA GAGTTGAGGA GACCTGAGAA TGAGTTTTGG 
GTCAAACTAA AGCCTGGCAG GGTCCTATTT ATAGACAACT GGCGTGTCCT ACATGGCAGG 
GAATGCTTCA CTGGCTACCG CCAACTGTGT GGCTGCTATT TAACAAGAGA TGATGTATTA 
AACACTGCTC GCCTCTTGGG GCTTCAGGCT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011529484.1
CDS	193..1305
Translation	MWVIKEMNQELKYANTVMRFDYVWLRDHCRSASCYNSKTHQRSLDTASVDLCIKPKTIRLDETTLFFTWPDGHVTKYDLNWLVKNSYEGQKQKVIQPRILWNAEIYQQAQVPSVDCQSFLETNEGLKKFLQNFLLYGIAFVENVPPTQEHTEKLAERISLIRETIYGRMWYFTSDFSRGDTAYTKLALDRHTDTTYFQEPCGIQVFHCLKHEGTGGRTLLVDGFYAAEQVLQKAPEEFELLSKVPLKHEYIEDVGECHNHMIGIGPVLNIYPWNKELYLIRYNNYDRAVINTVPYDVVHRWYTAHRTLTIELRRPENEFWVKLKPGRVLFIDNWRVLHGRECFTGYRQLCGCYLTRDDVLNTARLLGLQA

Target ORF information:

RefSeq Version	XM_011531182.3
Organism	Homo sapiens(human)
Definition	Homo sapiens trimethyllysine hydroxylase, epsilon (TMLHE), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011531182.3

ORF Insert Sequence:

ATGTGGGTTA TAAAAGAGAT GAATCAAGAG CTGAAATATG CTAATACCGT GATGCGCTTT 
GATTACGTCT GGCTTCGAGA CCACTGCCGC TCAGCATCGT GCTACAACTC TAAGACTCAC 
CAGCGCAGCC TGGATACTGC CAGTGTGGAT TTATGTATCA AGCCAAAGAC CATTCGTCTG 
GATGAGACCA CACTCTTTTT CACTTGGCCA GATGGTCATG TGACTAAATA TGATTTGAAT 
TGGCTGGTGA AAAACAGCTA TGAAGGGCAG AAACAAAAAG TCATCCAGCC TAGAATACTA 
TGGAATGCTG AAATCTACCA GCAAGCCCAA GTTCCATCGG TAGATTGCCA GAGCTTCTTA 
GAAACCAACG AGGGACTGAA GAAGTTTCTG CAAAACTTTC TGCTCTATGG AATTGCATTC 
GTAGAAAATG TCCCTCCCAC TCAAGAGCAC ACAGAGAAGT TGGCAGAAAG GATCAGCTTA 
ATCAGAGAAA CCATTTATGG GAGGATGTGG TATTTCACTT CAGACTTCTC CAGAGGTGAC 
ACTGCGTACA CCAAGCTAGC TCTGGATCGG CACACTGACA CTACCTATTT TCAAGAGCCC 
TGTGGCATTC AAGTGTTTCA TTGTCTTAAA CATGAAGGAA CTGGTGGCAG GACACTGCTA 
GTAGATGGAT TCTATGCAGC AGAACAGGTA CTTCAAAAGG CACCTGAGGA ATTTGAACTC 
CTCAGTAAAG TGCCATTGAA GCATGAATAT ATTGAAGATG TTGGAGAATG TCACAACCAC 
ATGATTGGGA TTGGGCCAGT CTTAAATATC TACCCATGGA ATAAAGAGCT GTATTTGATC 
AGGTACAACA ACTATGACCG GGCTGTCATC AATACCGTTC CTTATGATGT CGTCCATCGC 
TGGTATACAG CACACCGGAC TCTAACGATA GAGTTGAGGA GACCTGAGAA TGAGTTTTGG 
GTCAAACTAA AGCCTGGCAG GGTCCTATTT ATAGACAACT GGCGTGTCCT ACATGGCAGG 
GAATGCTTCA CTGGCTACCG CCAACTGTGT GGCTGCTATT TAACAAGAGA TGATGTATTA 
AACACTGCTC GCCTCTTGGG GCTTCAGGCT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMLHE ( XM_017029620.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016885109.1 Homo sapiens trimethyllysine hydroxylase, epsilon (TMLHE), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu99360
Clone ID Related Accession (Same CDS sequence)	XM_017029620.2 , XM_017029620.1
Accession Version	XM_017029620.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 780bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	trimethyllysine dioxygenase, mitochondrial isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017029620.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGGTACC ACAGATTGTC CCACCTACAC AGCAGGCTTC AGGACTTGCT GAAGGGAGGA 
GTCATATATC CGGCCCTTCC ACAGCCCAAC TTCAAAAGCT TACTTCCTTT AGCTGTCCAT 
TGGCACCATA CAGCCTCCAA GTCTCTGACT TGTGCTTGGC AGCAACATGA AGATCATTTT 
GAGCTGAAAT ATGCTAATAC CGTGATGCGC TTTGATTACG TCTGGCTTCG AGACCACTGC 
CGCTCAGCAT CGTGCTACAA CTCTAAGACT CACCAGCGCA GCCTGGATAC TGCCAGTGTG 
GATTTATGTA TCAAGCCAAA GACCATTCGT CTGGATGAGA CCACACTCTT TTTCACTTGG 
CCAGATGGTC ATGTGACTAA ATATGATTTG AATTGGCTGG TGAAAAACAG CTATGAAGGG 
CAGAAACAAA AAGTCATCCA GCCTAGAATA CTATGGAATG CTGAAATCTA CCAGCAAGCC 
CAAGTTCCAT CGGTAGATTG CCAGAGCTTC TTAGAAACCA ACGAGGGACT GAAGAAGTTT 
CTGCAAAACT TTCTGCTCTA TGGAATTGCA TTCGTAGAAA ATGTCCCTCC CACTCAAGAG 
CACACAGAGA AGTTGGCAGA AAGGATCAGC TTAATCAGAG AAACCATTTA TGGGAGGATG 
TGGTATTTCA CTTCAGACTT CTCCAGAGGT GACACTGCGT ACACCAAGCT AGCTCTGGAT 
CGGCACACTG ACACTACCTA TTTTCAAGAG CCCTGTGGAT TTCTTGCATT TAGTTATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016885109.1
CDS	146..925
Translation	MWYHRLSHLHSRLQDLLKGGVIYPALPQPNFKSLLPLAVHWHHTASKSLTCAWQQHEDHFELKYANTVMRFDYVWLRDHCRSASCYNSKTHQRSLDTASVDLCIKPKTIRLDETTLFFTWPDGHVTKYDLNWLVKNSYEGQKQKVIQPRILWNAEIYQQAQVPSVDCQSFLETNEGLKKFLQNFLLYGIAFVENVPPTQEHTEKLAERISLIRETIYGRMWYFTSDFSRGDTAYTKLALDRHTDTTYFQEPCGFLAFSY

Target ORF information:

RefSeq Version	XM_017029620.2
Organism	Homo sapiens(human)
Definition	Homo sapiens trimethyllysine hydroxylase, epsilon (TMLHE), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017029620.2

ORF Insert Sequence:

ATGTGGTACC ACAGATTGTC CCACCTACAC AGCAGGCTTC AGGACTTGCT GAAGGGAGGA 
GTCATATATC CGGCCCTTCC ACAGCCCAAC TTCAAAAGCT TACTTCCTTT AGCTGTCCAT 
TGGCACCATA CAGCCTCCAA GTCTCTGACT TGTGCTTGGC AGCAACATGA AGATCATTTT 
GAGCTGAAAT ATGCTAATAC CGTGATGCGC TTTGATTACG TCTGGCTTCG AGACCACTGC 
CGCTCAGCAT CGTGCTACAA CTCTAAGACT CACCAGCGCA GCCTGGATAC TGCCAGTGTG 
GATTTATGTA TCAAGCCAAA GACCATTCGT CTGGATGAGA CCACACTCTT TTTCACTTGG 
CCAGATGGTC ATGTGACTAA ATATGATTTG AATTGGCTGG TGAAAAACAG CTATGAAGGG 
CAGAAACAAA AAGTCATCCA GCCTAGAATA CTATGGAATG CTGAAATCTA CCAGCAAGCC 
CAAGTTCCAT CGGTAGATTG CCAGAGCTTC TTAGAAACCA ACGAGGGACT GAAGAAGTTT 
CTGCAAAACT TTCTGCTCTA TGGAATTGCA TTCGTAGAAA ATGTCCCTCC CACTCAAGAG 
CACACAGAGA AGTTGGCAGA AAGGATCAGC TTAATCAGAG AAACCATTTA TGGGAGGATG 
TGGTATTTCA CTTCAGACTT CTCCAGAGGT GACACTGCGT ACACCAAGCT AGCTCTGGAT 
CGGCACACTG ACACTACCTA TTTTCAAGAG CCCTGTGGAT TTCTTGCATT TAGTTATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMLHE ( XM_017029620.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016885109.1 Homo sapiens trimethyllysine hydroxylase, epsilon (TMLHE), transcript variant X3, mRNA.

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CloneID	OHu99360
Clone ID Related Accession (Same CDS sequence)	XM_017029620.2 , XM_017029620.1
Accession Version	XM_017029620.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 780bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	trimethyllysine dioxygenase, mitochondrial isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGGTACC ACAGATTGTC CCACCTACAC AGCAGGCTTC AGGACTTGCT GAAGGGAGGA 
GTCATATATC CGGCCCTTCC ACAGCCCAAC TTCAAAAGCT TACTTCCTTT AGCTGTCCAT 
TGGCACCATA CAGCCTCCAA GTCTCTGACT TGTGCTTGGC AGCAACATGA AGATCATTTT 
GAGCTGAAAT ATGCTAATAC CGTGATGCGC TTTGATTACG TCTGGCTTCG AGACCACTGC 
CGCTCAGCAT CGTGCTACAA CTCTAAGACT CACCAGCGCA GCCTGGATAC TGCCAGTGTG 
GATTTATGTA TCAAGCCAAA GACCATTCGT CTGGATGAGA CCACACTCTT TTTCACTTGG 
CCAGATGGTC ATGTGACTAA ATATGATTTG AATTGGCTGG TGAAAAACAG CTATGAAGGG 
CAGAAACAAA AAGTCATCCA GCCTAGAATA CTATGGAATG CTGAAATCTA CCAGCAAGCC 
CAAGTTCCAT CGGTAGATTG CCAGAGCTTC TTAGAAACCA ACGAGGGACT GAAGAAGTTT 
CTGCAAAACT TTCTGCTCTA TGGAATTGCA TTCGTAGAAA ATGTCCCTCC CACTCAAGAG 
CACACAGAGA AGTTGGCAGA AAGGATCAGC TTAATCAGAG AAACCATTTA TGGGAGGATG 
TGGTATTTCA CTTCAGACTT CTCCAGAGGT GACACTGCGT ACACCAAGCT AGCTCTGGAT 
CGGCACACTG ACACTACCTA TTTTCAAGAG CCCTGTGGAT TTCTTGCATT TAGTTATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016885109.1
CDS	172..951
Translation	MWYHRLSHLHSRLQDLLKGGVIYPALPQPNFKSLLPLAVHWHHTASKSLTCAWQQHEDHFELKYANTVMRFDYVWLRDHCRSASCYNSKTHQRSLDTASVDLCIKPKTIRLDETTLFFTWPDGHVTKYDLNWLVKNSYEGQKQKVIQPRILWNAEIYQQAQVPSVDCQSFLETNEGLKKFLQNFLLYGIAFVENVPPTQEHTEKLAERISLIRETIYGRMWYFTSDFSRGDTAYTKLALDRHTDTTYFQEPCGFLAFSY

Target ORF information:

RefSeq Version	XM_017029620.1
Organism	Homo sapiens(human)
Definition	Homo sapiens trimethyllysine hydroxylase, epsilon (TMLHE), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017029620.1

ORF Insert Sequence:

ATGTGGTACC ACAGATTGTC CCACCTACAC AGCAGGCTTC AGGACTTGCT GAAGGGAGGA 
GTCATATATC CGGCCCTTCC ACAGCCCAAC TTCAAAAGCT TACTTCCTTT AGCTGTCCAT 
TGGCACCATA CAGCCTCCAA GTCTCTGACT TGTGCTTGGC AGCAACATGA AGATCATTTT 
GAGCTGAAAT ATGCTAATAC CGTGATGCGC TTTGATTACG TCTGGCTTCG AGACCACTGC 
CGCTCAGCAT CGTGCTACAA CTCTAAGACT CACCAGCGCA GCCTGGATAC TGCCAGTGTG 
GATTTATGTA TCAAGCCAAA GACCATTCGT CTGGATGAGA CCACACTCTT TTTCACTTGG 
CCAGATGGTC ATGTGACTAA ATATGATTTG AATTGGCTGG TGAAAAACAG CTATGAAGGG 
CAGAAACAAA AAGTCATCCA GCCTAGAATA CTATGGAATG CTGAAATCTA CCAGCAAGCC 
CAAGTTCCAT CGGTAGATTG CCAGAGCTTC TTAGAAACCA ACGAGGGACT GAAGAAGTTT 
CTGCAAAACT TTCTGCTCTA TGGAATTGCA TTCGTAGAAA ATGTCCCTCC CACTCAAGAG 
CACACAGAGA AGTTGGCAGA AAGGATCAGC TTAATCAGAG AAACCATTTA TGGGAGGATG 
TGGTATTTCA CTTCAGACTT CTCCAGAGGT GACACTGCGT ACACCAAGCT AGCTCTGGAT 
CGGCACACTG ACACTACCTA TTTTCAAGAG CCCTGTGGAT TTCTTGCATT TAGTTATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Complex recombination with deletion in the F8 and duplication in the TMLHE mediated by int22h copies during early embryogenesis.
Thrombosis and haemostasis117(8)1478-1485(2017 Jul)
Chen C,Xie X,Wu X,Lu Y,Wang X,Wu W,Hu Y,Ding Q

Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function.
Molecular cell63(4)621-632(2016 Aug)
Floyd BJ,Wilkerson EM,Veling MT,Minogue CE,Xia C,Beebe ET,Wrobel RL,Cho H,Kremer LS,Alston CL,Gromek KA,Dolan BK,Ulbrich A,Stefely JA,Bohl SL,Werner KM,Jochem A,Westphall MS,Rensvold JW,Taylor RW,Prokisch H,Kim JP,Coon JJ,Pagliarini DJ

Analysis of the chromosome X exome in patients with autism spectrum disorders identified novel candidate genes, including TMLHE.
Translational psychiatry2e179(2012 Oct)
Nava C,Lamari F,H?ron D,Mignot C,Rastetter A,Keren B,Cohen D,Faudet A,Bouteiller D,Gilleron M,Jacquette A,Whalen S,Afenjar A,P?risse D,Laurent C,Dupuits C,Gautier C,G?rard M,Huguet G,Caillet S,Leheup B,Leboyer M,Gillberg C,Delorme R,Bourgeron T,Brice A,Depienne C

A common X-linked inborn error of carnitine biosynthesis may be a risk factor for nondysmorphic autism.
Proceedings of the National Academy of Sciences of the United States of America109(21)7974-81(2012 May)
Celestino-Soper PB,Violante S,Crawford EL,Luo R,Lionel AC,Delaby E,Cai G,Sadikovic B,Lee K,Lo C,Gao K,Person RE,Moss TJ,German JR,Huang N,Shinawi M,Treadwell-Deering D,Szatmari P,Roberts W,Fernandez B,Schroer RJ,Stevenson RE,Buxbaum JD,Betancur C,Scherer SW,Sanders SJ,Geschwind DH,Sutcliffe JS,Hurles ME,Wanders RJ,Shaw CA,Leal SM,Cook EH Jr,Goin-Kochel RP,Vaz FM,Beaudet AL

Use of array CGH to detect exonic copy number variants throughout the genome in autism families detects a novel deletion in TMLHE.
Human molecular genetics20(22)4360-70(2011 Nov)
Celestino-Soper PB,Shaw CA,Sanders SJ,Li J,Murtha MT,Ercan-Sencicek AG,Davis L,Thomson S,Gambin T,Chinault AC,Ou Z,German JR,Milosavljevic A,Sutcliffe JS,Cook EH Jr,Stankiewicz P,State MW,Beaudet AL

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TMLHE cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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