SMG8 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SMG8
Entrez Gene ID	55181
Full Name	SMG8, nonsense mediated mRNA decay factor
Synonyms	C17orf71
General protein information	Preferred Names SMG8, nonsense mediated mRNA decay factor Names protein SMG8 amplified in breast cancer gene 2 protein protein smg-8 homolog smg-8 homolog, nonsense mediated mRNA decay factor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q22
Disorder MIM:	613175

mRNA and Protein(s)

mRNA	Protein	Name
NM_018149.6	NP_060619.4	protein SMG8

Pathways from BioSystems

Homologies

Homo sapiens (human)	SMG8	NP_060619.4
Xenopus tropicalis (tropical clawed frog)	smg8	NP_001072291.1
Bos taurus (cattle)	SMG8	NP_001073755.1
Mus musculus (house mouse)	Smg8	NP_077224.1
	C17orf71	XP_001107695.1
Canis lupus familiaris (dog)	SMG8	XP_548236.1
Rattus norvegicus (Norway rat)	Smg8	XP_213430.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010179	XP_319357.4
Pan troglodytes (chimpanzee)	SMG8	XP_523682.1
Gallus gallus (chicken)	SMG8	XP_415875.4
Danio rerio (zebrafish)	smg8	XP_695811.2
Drosophila melanogaster (fruit fly)	CG6729	NP_609449.1

Gene Ontology
Bibliography

Related articles in PubMed

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M
Cell163(3)712-23(2015 Oct)

Inhibition of SMG-8, a subunit of SMG-1 kinase, ameliorates nonsense-mediated mRNA decay-exacerbated mutant phenotypes without cytotoxicity.
Usuki F, Yamashita A, Shiraishi T, Shiga A, Onodera O, Higuchi I, Ohno S
Proceedings of the National Academy of Sciences of the United States of America110(37)15037-42(2013 Sep)

Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.
Reiner AP, Hartiala J, Zeller T, Bis JC, Dupuis J, Fornage M, Baumert J, Kleber ME, Wild PS, Baldus S, Bielinski SJ, Fontes JD, Illig T, Keating BJ, Lange LA, Ojeda F, M?ller-Nurasyid M, Munzel TF, Psaty BM, Rice K, Rotter JI, Schnabel RB, Tang WH, Thorand B, Erdmann J, , Jacobs DR Jr, Wilson JG, Koenig W, Tracy RP, Blankenberg S, M?rz W, Gross MD, Benjamin EJ, Hazen SL, Allayee H
Human molecular genetics22(16)3381-93(2013 Aug)

The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8.
Arias-Palomo E, Yamashita A, Fern?ndez IS, N??ez-Ram?rez R, Bamba Y, Izumi N, Ohno S, Llorca O
Genes & development25(2)153-64(2011 Jan)

Characterization of SMG-9, an essential component of the nonsense-mediated mRNA decay SMG1C complex.
Fern?ndez IS, Yamashita A, Arias-Palomo E, Bamba Y, Bartolom? RA, Canales MA, Teixid? J, Ohno S, Llorca O
Nucleic acids research39(1)347-58(2011 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

knockdown of SMG-8 produced the best effect for restoring defective mRNA and protein levels without affecting cell growth, cell-cycle progression, or endoplasmic reticulum stress in Ullrich congenital muscular dystrophy fibroblasts
Title: Inhibition of SMG-8, a subunit of SMG-1 kinase, ameliorates nonsense-mediated mRNA decay-exacerbated mutant phenotypes without cytotoxicity.

large-scale conformational changes induced by SMG-8 after SMG-9-mediated recruitment tune SMG-1 kinase activity to modulate nonsense-mediated mRNA decay
Title: The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8.

The following SMG8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SMG8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu13521	NM_018149.6 Latest version!	Homo sapiens SMG8 nonsense mediated mRNA decay factor (SMG8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SMG8 ( NM_018149.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_060619.4 Homo sapiens SMG8 nonsense mediated mRNA decay factor (SMG8), mRNA.

Price & Availability↑

CloneID	OHu13521
Clone ID Related Accession (Same CDS sequence)	NM_018149.6
Accession Version	NM_018149.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2976bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	protein SMG8
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF349467.1, AL834490.1 and AK026858.1. On Oct 28, 2006 this sequence version replaced NM_018149.5. ##Evidence-Data-START## Transcript exon combination :: AK026858.1, AL834490.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTGGTC CCGTGAGCTT GCGAGACCTT CTAATGGGAG CATCAGCCTG GATGGGCTCT 
GAAAGTCCCG GAGGGTCCCC TACTGAGGGC GGAGGGAGCG CGGCTGGCGG ACCGGAGCCT 
CCATGGCGGG AGGATGAGAT CTGCGTTGTG GGAATCTTCG GCAAGACGGC TCTACGCCTG 
AATTCCGAGA AGTTCTCTCT TGTGAATACG GTGTGCGACC GACAGGTCTT TCCTCTCTTT 
CGCCACCAAG ATCCTGGGGA TCCAGGACCT GGAATCAGAA CTGAGGCTGG CGCCGTGGGT 
GAGGCCGGTG GAGCCGAGGA CCCTGGGGCT GCAGCCGGGG GTTCAGTTCG GGGAAGTGGA 
GCTGTCGCGG AAGGTAACCG AACTGAGGCA GGCTCCCAGG ACTACAGCCT TCTGCAGGCC 
TACTACAGTC AGGAAAGCAA AGTTCTGTAT CTTCTCCTCA CCTCCATCTG TGACAATTCA 
CAGCTTCTCC GGGCTTGTCG GGCTCTTCAG AGCGGGGAAG CTGGAGGTGG ACTCTCTTTA 
CCTCATGCAG AAGCACACGA GTTCTGGAAG CATCAAGAGA AGCTGCAGTG CCTCAGTCTC 
CTTTACCTAT TCTCTGTCTG TCATATCTTG CTTCTGGTCC ATCCCACTTG TTCCTTTGAT 
ATCACTTATG ATCGAGTATT CAGAGCCCTG GATGGGCTGA GACAGAAGGT CCTGCCGCTC 
CTTAAAACAG CCATTAAGGA TTGTCCAGTT GGCAAAGACT GGAAGCTAAA CTGCCGACCT 
TGCCCACCTA GACTCCTTTT CCTCTTTCAA CTCAATGGAG CCCTCAAGGT AGAACCTCCT 
CGGAACCAAG ACCCAGCTCA TCCAGACAAG CCCAAGAAAC ATTCTCCCAA AAGGAGGCTG 
CAGCATGCCC TGGAGGACCA GATCTATAGA ATCTTCCGGA AGAGTCGTGT CTTGACTAAT 
CAGAGCATCA ACTGCCTCTT TACTGTGCCT GCCAACCAAG CTTTCGTGTA CATAGTACCG 
GGAAGCCAGG AGGAGGACCC AGTAGGTATG TTGCTGGACC AACTTAGGAG TCATTGTACT 
GTGAAGGACC CGGAATCTTT GCTGGTGCCT GCACCCCTTT CTGGGCCTAG GCGATACCAG 
GTGATGAGGC AGCACAGCCG ACAACAACTT TCCTTTCACA TTGACAGCAG CAGTTCCAGT 
TCTTCAGGCC AGCTAGTGGA TTTCACTCTT CGGGAATTCC TATGGCAGCA TGTGGAGCTA 
GTTCTAAGCA AGAAAGGTTT CGATGACAGT GTGGGCAGGA ACCCACAGCC TTCCCATTTT 
GAACTTCCTA CTTATCAGAA GTGGATCTCA GCAGCTTCAA AACTGTATGA GGTGGCTATT 
GATGGGAAAG AAGAGGACTT GGGGTCACCC ACTGGAGAGC TAACATCTAA GATTTTAAGC 
AGTATTAAAG TCTTGGAAGG ATTTTTGGAT ATTGACACAA AATTCTCAGA AAACCGATGC 
CAAAAAGCTT TACCCATGGC CCACAGTGCC TACCAGTCAA ATTTGCCTCA TAATTACACA 
ATGACTGTCC ATAAGAATCA GCTTGCCCAG GCTCTTCGAG TGTACAGTCA ACATGCTAGA 
GGTCCAGCAT TTCACAAATA CGCCATGCAG TTACATGAGG ACTGCTACAA ATTTTGGAGC 
AATGGCCATC AGCTCTGTGA GGAGAGGAGT TTAACTGATC AACACTGTGT GCACAAATTT 
CACTCATTAC CTAAATCAGG AGAAAAACCA GAGGCTGATA GAAATCCGCC TGTGCTATAT 
CACAATAGCC GAGCTCGATC TACTGGTGCT TGCAACTGTG GAAGGAAACA AGCACCTCGA 
GATGATCCCT TTGATATCAA AGCAGCCAAT TATGACTTCT ATCAGCTTCT GGAAGAAAAG 
TGTTGTGGAA AATTGGATCA TATCAATTTC CCAGTATTTG AACCAAGTAC TCCAGATCCT 
GCTCCTGCTA AAAATGAATC CTCTCCTGCT CCTCCAGATT CGGATGCTGA TAAACTTAAA 
GAAAAAGAAC CTCAAACCCA AGGAGAGAGC ACGAGCCTGA GTTTAGCTTT GAGTTTGGGC 
CAATCCACAG ATAGCTTAGG TACCTATCCA GCTGATCCAC AAGCAGGAGG AGATAATCCA 
GAAGTTCATG GTCAAGTAGA AGTGAAAACT GAGAAGAGGC CAAACTTCGT TGATCGACAG 
GCATCCACAG TTGAGTATCT CCCAGGCATG CTACATTCAA ATTGCCCTAA AGGTCTCCTA 
CCCAAATTCT CCAGCTGGTC TTTGGTTAAA CTAGGCCCTG CTAAGTCTTA TAACTTTCAT 
ACAGGTTTGG ACCAACAGGG CTTTATTCCA GGAACAAATT ATCTTATGCC TTGGGACATT 
GTCATCAGGA CTAGAGCTGA AGATGAAGGA GACTTAGACA CAAACTCTTG GCCTGCTCCA 
AATAAAGCTA TTCCTGGAAA GAGAAGTGCG GTTGTAATGG GAAGAGGAAG ACGGCGAGAT 
GACATAGCTC GAGCTTTTGT GGGCTTTGAA TATGAAGACT CTCGAGGTCG GAGATTCATG 
TGCTCTGGGC CTGACAAAGT AATGAAAGTA ATGGGAAGTG GGCCAAAGGA ATCAGCTTTA 
AAAGCCCTAA ATAGTGACAT GCCCTTATAT ATTCTGTCAT CCTCTCAAGG TAGAGGGCTG 
AAACCTCATT ATGCTCAACT TATGAGGCTT TTTGTTGTGG TTCCTGATGC TCCTTTGCAG 
ATAATACTAA TGCCTCAGGT TCAGCCAGGC CCACCACCAT GTCCGGTATT CTACCCAGAA 
AAACAAGAAA TCACCCTTCC ACCTGATGGC CTTTGGGTTT TGAGATTTCC TTATGCATAT 
GTGACTGAGA GAGGACCTTG TTTCCCCCCT AAGGAAAATG TGCAGTTAAT GAGCTACAAG 
GTGCTCCGTG GGGTTCTTAA GGCAGTAACA CAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060619.4
CDS	43..3018
Translation	MAGPVSLRDLLMGASAWMGSESPGGSPTEGGGSAAGGPEPPWREDEICVVGIFGKTALRLNSEKFSLVNTVCDRQVFPLFRHQDPGDPGPGIRTEAGAVGEAGGAEDPGAAAGGSVRGSGAVAEGNRTEAGSQDYSLLQAYYSQESKVLYLLLTSICDNSQLLRACRALQSGEAGGGLSLPHAEAHEFWKHQEKLQCLSLLYLFSVCHILLLVHPTCSFDITYDRVFRALDGLRQKVLPLLKTAIKDCPVGKDWKLNCRPCPPRLLFLFQLNGALKVEPPRNQDPAHPDKPKKHSPKRRLQHALEDQIYRIFRKSRVLTNQSINCLFTVPANQAFVYIVPGSQEEDPVGMLLDQLRSHCTVKDPESLLVPAPLSGPRRYQVMRQHSRQQLSFHIDSSSSSSSGQLVDFTLREFLWQHVELVLSKKGFDDSVGRNPQPSHFELPTYQKWISAASKLYEVAIDGKEEDLGSPTGELTSKILSSIKVLEGFLDIDTKFSENRCQKALPMAHSAYQSNLPHNYTMTVHKNQLAQALRVYSQHARGPAFHKYAMQLHEDCYKFWSNGHQLCEERSLTDQHCVHKFHSLPKSGEKPEADRNPPVLYHNSRARSTGACNCGRKQAPRDDPFDIKAANYDFYQLLEEKCCGKLDHINFPVFEPSTPDPAPAKNESSPAPPDSDADKLKEKEPQTQGESTSLSLALSLGQSTDSLGTYPADPQAGGDNPEVHGQVEVKTEKRPNFVDRQASTVEYLPGMLHSNCPKGLLPKFSSWSLVKLGPAKSYNFHTGLDQQGFIPGTNYLMPWDIVIRTRAEDEGDLDTNSWPAPNKAIPGKRSAVVMGRGRRRDDIARAFVGFEYEDSRGRRFMCSGPDKVMKVMGSGPKESALKALNSDMPLYILSSSQGRGLKPHYAQLMRLFVVVPDAPLQIILMPQVQPGPPPCPVFYPEKQEITLPPDGLWVLRFPYAYVTERGPCFPPKENVQLMSYKVLRGVLKAVTQ

Target ORF information:

RefSeq Version	NM_018149.6
Organism	Homo sapiens(human)
Definition	Homo sapiens SMG8 nonsense mediated mRNA decay factor (SMG8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018149.6

ORF Insert Sequence:

ATGGCTGGTC CCGTGAGCTT GCGAGACCTT CTAATGGGAG CATCAGCCTG GATGGGCTCT 
GAAAGTCCCG GAGGGTCCCC TACTGAGGGC GGAGGGAGCG CGGCTGGCGG ACCGGAGCCT 
CCATGGCGGG AGGATGAGAT CTGCGTTGTG GGAATCTTCG GCAAGACGGC TCTACGCCTG 
AATTCCGAGA AGTTCTCTCT TGTGAATACG GTGTGCGACC GACAGGTCTT TCCTCTCTTT 
CGCCACCAAG ATCCTGGGGA TCCAGGACCT GGAATCAGAA CTGAGGCTGG CGCCGTGGGT 
GAGGCCGGTG GAGCCGAGGA CCCTGGGGCT GCAGCCGGGG GTTCAGTTCG GGGAAGTGGA 
GCTGTCGCGG AAGGTAACCG AACTGAGGCA GGCTCCCAGG ACTACAGCCT TCTGCAGGCC 
TACTACAGTC AGGAAAGCAA AGTTCTGTAT CTTCTCCTCA CCTCCATCTG TGACAATTCA 
CAGCTTCTCC GGGCTTGTCG GGCTCTTCAG AGCGGGGAAG CTGGAGGTGG ACTCTCTTTA 
CCTCATGCAG AAGCACACGA GTTCTGGAAG CATCAAGAGA AGCTGCAGTG CCTCAGTCTC 
CTTTACCTAT TCTCTGTCTG TCATATCTTG CTTCTGGTCC ATCCCACTTG TTCCTTTGAT 
ATCACTTATG ATCGAGTATT CAGAGCCCTG GATGGGCTGA GACAGAAGGT CCTGCCGCTC 
CTTAAAACAG CCATTAAGGA TTGTCCAGTT GGCAAAGACT GGAAGCTAAA CTGCCGACCT 
TGCCCACCTA GACTCCTTTT CCTCTTTCAA CTCAATGGAG CCCTCAAGGT AGAACCTCCT 
CGGAACCAAG ACCCAGCTCA TCCAGACAAG CCCAAGAAAC ATTCTCCCAA AAGGAGGCTG 
CAGCATGCCC TGGAGGACCA GATCTATAGA ATCTTCCGGA AGAGTCGTGT CTTGACTAAT 
CAGAGCATCA ACTGCCTCTT TACTGTGCCT GCCAACCAAG CTTTCGTGTA CATAGTACCG 
GGAAGCCAGG AGGAGGACCC AGTAGGTATG TTGCTGGACC AACTTAGGAG TCATTGTACT 
GTGAAGGACC CGGAATCTTT GCTGGTGCCT GCACCCCTTT CTGGGCCTAG GCGATACCAG 
GTGATGAGGC AGCACAGCCG ACAACAACTT TCCTTTCACA TTGACAGCAG CAGTTCCAGT 
TCTTCAGGCC AGCTAGTGGA TTTCACTCTT CGGGAATTCC TATGGCAGCA TGTGGAGCTA 
GTTCTAAGCA AGAAAGGTTT CGATGACAGT GTGGGCAGGA ACCCACAGCC TTCCCATTTT 
GAACTTCCTA CTTATCAGAA GTGGATCTCA GCAGCTTCAA AACTGTATGA GGTGGCTATT 
GATGGGAAAG AAGAGGACTT GGGGTCACCC ACTGGAGAGC TAACATCTAA GATTTTAAGC 
AGTATTAAAG TCTTGGAAGG ATTTTTGGAT ATTGACACAA AATTCTCAGA AAACCGATGC 
CAAAAAGCTT TACCCATGGC CCACAGTGCC TACCAGTCAA ATTTGCCTCA TAATTACACA 
ATGACTGTCC ATAAGAATCA GCTTGCCCAG GCTCTTCGAG TGTACAGTCA ACATGCTAGA 
GGTCCAGCAT TTCACAAATA CGCCATGCAG TTACATGAGG ACTGCTACAA ATTTTGGAGC 
AATGGCCATC AGCTCTGTGA GGAGAGGAGT TTAACTGATC AACACTGTGT GCACAAATTT 
CACTCATTAC CTAAATCAGG AGAAAAACCA GAGGCTGATA GAAATCCGCC TGTGCTATAT 
CACAATAGCC GAGCTCGATC TACTGGTGCT TGCAACTGTG GAAGGAAACA AGCACCTCGA 
GATGATCCCT TTGATATCAA AGCAGCCAAT TATGACTTCT ATCAGCTTCT GGAAGAAAAG 
TGTTGTGGAA AATTGGATCA TATCAATTTC CCAGTATTTG AACCAAGTAC TCCAGATCCT 
GCTCCTGCTA AAAATGAATC CTCTCCTGCT CCTCCAGATT CGGATGCTGA TAAACTTAAA 
GAAAAAGAAC CTCAAACCCA AGGAGAGAGC ACGAGCCTGA GTTTAGCTTT GAGTTTGGGC 
CAATCCACAG ATAGCTTAGG TACCTATCCA GCTGATCCAC AAGCAGGAGG AGATAATCCA 
GAAGTTCATG GTCAAGTAGA AGTGAAAACT GAGAAGAGGC CAAACTTCGT TGATCGACAG 
GCATCCACAG TTGAGTATCT CCCAGGCATG CTACATTCAA ATTGCCCTAA AGGTCTCCTA 
CCCAAATTCT CCAGCTGGTC TTTGGTTAAA CTAGGCCCTG CTAAGTCTTA TAACTTTCAT 
ACAGGTTTGG ACCAACAGGG CTTTATTCCA GGAACAAATT ATCTTATGCC TTGGGACATT 
GTCATCAGGA CTAGAGCTGA AGATGAAGGA GACTTAGACA CAAACTCTTG GCCTGCTCCA 
AATAAAGCTA TTCCTGGAAA GAGAAGTGCG GTTGTAATGG GAAGAGGAAG ACGGCGAGAT 
GACATAGCTC GAGCTTTTGT GGGCTTTGAA TATGAAGACT CTCGAGGTCG GAGATTCATG 
TGCTCTGGGC CTGACAAAGT AATGAAAGTA ATGGGAAGTG GGCCAAAGGA ATCAGCTTTA 
AAAGCCCTAA ATAGTGACAT GCCCTTATAT ATTCTGTCAT CCTCTCAAGG TAGAGGGCTG 
AAACCTCATT ATGCTCAACT TATGAGGCTT TTTGTTGTGG TTCCTGATGC TCCTTTGCAG 
ATAATACTAA TGCCTCAGGT TCAGCCAGGC CCACCACCAT GTCCGGTATT CTACCCAGAA 
AAACAAGAAA TCACCCTTCC ACCTGATGGC CTTTGGGTTT TGAGATTTCC TTATGCATAT 
GTGACTGAGA GAGGACCTTG TTTCCCCCCT AAGGAAAATG TGCAGTTAAT GAGCTACAAG 
GTGCTCCGTG GGGTTCTTAA GGCAGTAACA CAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Cell163(3)712-23(2015 Oct)
Hein MY,Hubner NC,Poser I,Cox J,Nagaraj N,Toyoda Y,Gak IA,Weisswange I,Mansfeld J,Buchholz F,Hyman AA,Mann M

Inhibition of SMG-8, a subunit of SMG-1 kinase, ameliorates nonsense-mediated mRNA decay-exacerbated mutant phenotypes without cytotoxicity.
Proceedings of the National Academy of Sciences of the United States of America110(37)15037-42(2013 Sep)
Usuki F,Yamashita A,Shiraishi T,Shiga A,Onodera O,Higuchi I,Ohno S

Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.
Human molecular genetics22(16)3381-93(2013 Aug)
Reiner AP,Hartiala J,Zeller T,Bis JC,Dupuis J,Fornage M,Baumert J,Kleber ME,Wild PS,Baldus S,Bielinski SJ,Fontes JD,Illig T,Keating BJ,Lange LA,Ojeda F,M?ller-Nurasyid M,Munzel TF,Psaty BM,Rice K,Rotter JI,Schnabel RB,Tang WH,Thorand B,Erdmann J,,Jacobs DR Jr,Wilson JG,Koenig W,Tracy RP,Blankenberg S,M?rz W,Gross MD,Benjamin EJ,Hazen SL,Allayee H

The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8.
Genes & development25(2)153-64(2011 Jan)
Arias-Palomo E,Yamashita A,Fern?ndez IS,N??ez-Ram?rez R,Bamba Y,Izumi N,Ohno S,Llorca O

Characterization of SMG-9, an essential component of the nonsense-mediated mRNA decay SMG1C complex.
Nucleic acids research39(1)347-58(2011 Jan)
Fern?ndez IS,Yamashita A,Arias-Palomo E,Bamba Y,Bartolom? RA,Canales MA,Teixid? J,Ohno S,Llorca O

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SMG8 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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