TRIM68 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TRIM68
Entrez Gene ID	55128
Full Name	tripartite motif containing 68
Synonyms	GC109,RNF137,SS-56,SS56
General protein information	Preferred Names tripartite motif containing 68 Names E3 ubiquitin-protein ligase TRIM68 RING-type E3 ubiquitin transferase TRIM68 Ro/SSA1 related protein SSA protein SS-56 ring finger protein 137 tripartite motif-containing protein 68
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11p15.4
Summary	This gene encodes a member of the tripartite motif-containing protein family, whose members are characterized by a 'really interesting new gene' (RING) finger domain, a zinc-binding B-box motif, and a coiled-coil region. Members of this family function as E3 ubiquitin ligases and are involved in a broad range of biological processes. This gene regulates the activation of nuclear receptors, such as androgen receptor, and has been implicated in development of prostate cancer cells, where its expression increases in response to a downregulation of microRNAs. In addition, this gene participates in viral defense regulation as a negative regulator of interferon-beta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].
Disorder MIM:	613184

mRNA and Protein(s)

mRNA	Protein	Name
NM_001304496.1	NP_001291425.1	E3 ubiquitin-protein ligase TRIM68 isoform 2
NM_001304496.2	NP_001291425.1	E3 ubiquitin-protein ligase TRIM68 isoform 2
NM_018073.8	NP_060543.5	E3 ubiquitin-protein ligase TRIM68 isoform 1
NM_018073.7	NP_060543.5	E3 ubiquitin-protein ligase TRIM68 isoform 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	TRIM68	NP_060543.5
Pan troglodytes (chimpanzee)	TRIM68	XP_521739.2
Bos taurus (cattle)	TRIM68	NP_001192500.1
	TRIM68	XP_001112587.1
Mus musculus (house mouse)	Trim68	NP_932129.2
Rattus norvegicus (Norway rat)	Trim68	XP_003748987.2
Canis lupus familiaris (dog)	TRIM68	XP_542351.1

Gene Ontology
Bibliography

Related articles in PubMed

TRIM68 negatively regulates IFN-? production by degrading TRK fused gene, a novel driver of IFN-? downstream of anti-viral detection systems.
Wynne C, Lazzari E, Smith S, McCarthy EM, N? Gabhann J, Kallal LE, Higgs R, Greco A, Cryan SA, Biron CA, Jefferies CA
PloS one9(7)e101503(2014)

Epigenetic deregulation of miR-29a and miR-1256 by isoflavone contributes to the inhibition of prostate cancer cell growth and invasion.
Li Y, Kong D, Ahmad A, Bao B, Dyson G, Sarkar FH
Epigenetics7(8)940-9(2012 Aug)

TRIM proteins and cancer.
Hatakeyama S
Nature reviews. Cancer11(11)792-804(2011 10)

Melanoma inhibitor of apoptosis protein (ML-IAP) specific cytotoxic T lymphocytes cross-react with an epitope from the auto-antigen SS56.
Baek S?rensen R, Faurschou M, Troelsen L, Schrama D, Jacobsen S, Becker JC, Thor Straten P, Andersen MH
The Journal of investigative dermatology129(8)1992-9(2009 Aug)

TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells.
Miyajima N, Maruyama S, Bohgaki M, Kano S, Shigemura M, Shinohara N, Nonomura K, Hatakeyama S
Cancer research68(9)3486-94(2008 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TRIM68 targets TFG, a novel regulator of IFN production, and in doing so turns off and limits type I IFN production in response to anti-viral detection systems
Title: TRIM68 negatively regulates IFN-? production by degrading TRK fused gene, a novel driver of IFN-? downstream of anti-viral detection systems.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genome-wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations-significant evidence for linkage on chromosome 4q in African Americans: the Family Investigation of Nephropathy and Diabetes Research Group.

TRIM68 functions as a cofactor for AR-mediated transcription and is likely to be a novel diagnostic tool and a potentially therapeutic target for prostate cancer.
Title: TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells.

The following TRIM68 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TRIM68 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12266	NM_018073.8 Latest version!	Homo sapiens tripartite motif containing 68 (TRIM68), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
OHu69025	NM_001304496.2 Latest version!	Homo sapiens tripartite motif containing 68 (TRIM68), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu69025	NM_001304496.1	Homo sapiens tripartite motif containing 68 (TRIM68), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu12266	NM_018073.7	Homo sapiens tripartite motif containing 68 (TRIM68), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TRIM68 ( NM_018073.8 ) cDNA ORF clone, Homo sapiens(human) -> NP_060543.5 Homo sapiens tripartite motif containing 68 (TRIM68), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu12266
Clone ID Related Accession (Same CDS sequence)	NM_018073.8 , NM_018073.7
Accession Version	NM_018073.8 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1458bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase TRIM68 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC090719.8. On Nov 23, 2018 this sequence version replaced NM_018073.7. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: SRR1803617.118822.1, SRR1803616.248038.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000300747.10/ ENSP00000300747.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGATCCCA CAGCCTTGGT GGAAGCCATT GTGGAAGAAG TGGCCTGTCC CATCTGTATG 
ACCTTCCTGA GGGAGCCCAT GAGCATTGAC TGTGGCCACA GCTTCTGCCA CAGCTGTCTC 
TCTGGACTCT GGGAGATCCC AGGAGAATCC CAGAACTGGG GTTACACCTG TCCCCTCTGT 
CGAGCTCCTG TCCAGCCAAG GAACCTGCGG CCTAATTGGC AGCTGGCCAA TGTTGTAGAA 
AAAGTCCGTC TGCTAAGGCT ACATCCAGGA ATGGGGCTGA AGGGTGACCT GTGTGAGCGC 
CATGGGGAAA AGCTGAAGAT GTTCTGCAAA GAGGATGTCT TGATAATGTG TGAGGCCTGC 
AGCCAGTCCC CAGAGCATGA GGCCCACAGT GTTGTGCCAA TGGAGGATGT TGCCTGGGAG 
TACAAGTGGG AACTTCATGA GGCCCTCGAA CATCTGAAGA AAGAGCAAGA AGAGGCCTGG 
AAGCTTGAAG TTGGTGAAAG GAAACGAACT GCCACCTGGA AGATACAGGT GGAAACCCGA 
AAACAGAGTA TTGTATGGGA GTTTGAAAAA TACCAGCGAT TACTAGAGAA AAAGCAGCCA 
CCACATCGGC AGCTGGGGGC AGAGGTAGCA GCAGCTCTGG CCAGCCTACA GCGGGAGGCA 
GCGGAGACCA TGCAGAAACT GGAGTTGAAC CATAGCGAGC TCATCCAGCA GAGCCAGGTC 
CTGTGGAGGA TGATTGCAGA GTTGAAAGAG AGGTCGCAGA GGCCTGTCCG CTGGATGTTG 
CAGGATATTC AGGAAGTGTT AAACAGGAGC AAATCTTGGA GCTTGCAGCA GCCAGAACCA 
ATCTCCCTGG AGTTGAAGAC AGATTGCCGT GTGCTGGGGC TAAGAGAGAT CCTGAAGACT 
TATGCAGCTG ATGTGCGCTT GGATCCAGAT ACTGCTTACT CCCGTCTCAT CGTGTCTGAG 
GACAGAAAAC GTGTGCACTA TGGAGACACC AACCAGAAAC TGCCAGACAA TCCTGAGAGA 
TTTTACCGCT ATAATATCGT CCTGGGAAGC CAGTGCATCT CCTCAGGCCG GCACTACTGG 
GAGGTGGAGG TGGGAGACAG GTCTGAGTGG GGCCTGGGAG TATGTAAGCA AAATGTAGAC 
CGGAAGGAGG TGGTCTACTT ATCCCCCCAC TATGGATTCT GGGTGATAAG GCTGAGGAAG 
GGAAATGAGT ACCGAGCAGG CACCGATGAG TACCCAATCC TGTCCTTGCC GGTCCCTCCT 
CGCCGGGTGG GAATCTTCGT GGATTATGAG GCCCATGACA TTTCTTTCTA CAATGTGACT 
GACTGTGGCT CCCACATCTT CACTTTCCCC CGCTATCCCT TCCCTGGGCG CCTCCTGCCC 
TATTTTAGTC CTTGCTACAG CATTGGAACC AACAACACTG CTCCTCTGGC CATCTGCTCC 
CTGGATGGGG AGGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060543.5
CDS	263..1720
Translation	MDPTALVEAIVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQNWGYTCPLCRAPVQPRNLRPNWQLANVVEKVRLLRLHPGMGLKGDLCERHGEKLKMFCKEDVLIMCEACSQSPEHEAHSVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTATWKIQVETRKQSIVWEFEKYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELIQQSQVLWRMIAELKERSQRPVRWMLQDIQEVLNRSKSWSLQQPEPISLELKTDCRVLGLREILKTYAADVRLDPDTAYSRLIVSEDRKRVHYGDTNQKLPDNPERFYRYNIVLGSQCISSGRHYWEVEVGDRSEWGLGVCKQNVDRKEVVYLSPHYGFWVIRLRKGNEYRAGTDEYPILSLPVPPRRVGIFVDYEAHDISFYNVTDCGSHIFTFPRYPFPGRLLPYFSPCYSIGTNNTAPLAICSLDGED

Target ORF information:

RefSeq Version	NM_018073.8
Organism	Homo sapiens(human)
Definition	Homo sapiens tripartite motif containing 68 (TRIM68), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018073.8

ORF Insert Sequence:

ATGGATCCCA CAGCCTTGGT GGAAGCCATT GTGGAAGAAG TGGCCTGTCC CATCTGTATG 
ACCTTCCTGA GGGAGCCCAT GAGCATTGAC TGTGGCCACA GCTTCTGCCA CAGCTGTCTC 
TCTGGACTCT GGGAGATCCC AGGAGAATCC CAGAACTGGG GTTACACCTG TCCCCTCTGT 
CGAGCTCCTG TCCAGCCAAG GAACCTGCGG CCTAATTGGC AGCTGGCCAA TGTTGTAGAA 
AAAGTCCGTC TGCTAAGGCT ACATCCAGGA ATGGGGCTGA AGGGTGACCT GTGTGAGCGC 
CATGGGGAAA AGCTGAAGAT GTTCTGCAAA GAGGATGTCT TGATAATGTG TGAGGCCTGC 
AGCCAGTCCC CAGAGCATGA GGCCCACAGT GTTGTGCCAA TGGAGGATGT TGCCTGGGAG 
TACAAGTGGG AACTTCATGA GGCCCTCGAA CATCTGAAGA AAGAGCAAGA AGAGGCCTGG 
AAGCTTGAAG TTGGTGAAAG GAAACGAACT GCCACCTGGA AGATACAGGT GGAAACCCGA 
AAACAGAGTA TTGTATGGGA GTTTGAAAAA TACCAGCGAT TACTAGAGAA AAAGCAGCCA 
CCACATCGGC AGCTGGGGGC AGAGGTAGCA GCAGCTCTGG CCAGCCTACA GCGGGAGGCA 
GCGGAGACCA TGCAGAAACT GGAGTTGAAC CATAGCGAGC TCATCCAGCA GAGCCAGGTC 
CTGTGGAGGA TGATTGCAGA GTTGAAAGAG AGGTCGCAGA GGCCTGTCCG CTGGATGTTG 
CAGGATATTC AGGAAGTGTT AAACAGGAGC AAATCTTGGA GCTTGCAGCA GCCAGAACCA 
ATCTCCCTGG AGTTGAAGAC AGATTGCCGT GTGCTGGGGC TAAGAGAGAT CCTGAAGACT 
TATGCAGCTG ATGTGCGCTT GGATCCAGAT ACTGCTTACT CCCGTCTCAT CGTGTCTGAG 
GACAGAAAAC GTGTGCACTA TGGAGACACC AACCAGAAAC TGCCAGACAA TCCTGAGAGA 
TTTTACCGCT ATAATATCGT CCTGGGAAGC CAGTGCATCT CCTCAGGCCG GCACTACTGG 
GAGGTGGAGG TGGGAGACAG GTCTGAGTGG GGCCTGGGAG TATGTAAGCA AAATGTAGAC 
CGGAAGGAGG TGGTCTACTT ATCCCCCCAC TATGGATTCT GGGTGATAAG GCTGAGGAAG 
GGAAATGAGT ACCGAGCAGG CACCGATGAG TACCCAATCC TGTCCTTGCC GGTCCCTCCT 
CGCCGGGTGG GAATCTTCGT GGATTATGAG GCCCATGACA TTTCTTTCTA CAATGTGACT 
GACTGTGGCT CCCACATCTT CACTTTCCCC CGCTATCCCT TCCCTGGGCG CCTCCTGCCC 
TATTTTAGTC CTTGCTACAG CATTGGAACC AACAACACTG CTCCTCTGGC CATCTGCTCC 
CTGGATGGGG AGGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TRIM68 ( NM_018073.7 ) cDNA ORF clone, Homo sapiens(human) -> NP_060543.5 Homo sapiens tripartite motif containing 68 (TRIM68), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu12266
Clone ID Related Accession (Same CDS sequence)	NM_018073.8 , NM_018073.7
Accession Version	NM_018073.7	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1458bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-28
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase TRIM68 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC402744.1, AL832730.1 and AC090719.8. On Jan 30, 2015 this sequence version replaced NM_018073.6. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: AL832730.1, SRR1803616.222166.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATCCCA CAGCCTTGGT GGAAGCCATT GTGGAAGAAG TGGCCTGTCC CATCTGTATG 
ACCTTCCTGA GGGAGCCCAT GAGCATTGAC TGTGGCCACA GCTTCTGCCA CAGCTGTCTC 
TCTGGACTCT GGGAGATCCC AGGAGAATCC CAGAACTGGG GTTACACCTG TCCCCTCTGT 
CGAGCTCCTG TCCAGCCAAG GAACCTGCGG CCTAATTGGC AGCTGGCCAA TGTTGTAGAA 
AAAGTCCGTC TGCTAAGGCT ACATCCAGGA ATGGGGCTGA AGGGTGACCT GTGTGAGCGC 
CATGGGGAAA AGCTGAAGAT GTTCTGCAAA GAGGATGTCT TGATAATGTG TGAGGCCTGC 
AGCCAGTCCC CAGAGCATGA GGCCCACAGT GTTGTGCCAA TGGAGGATGT TGCCTGGGAG 
TACAAGTGGG AACTTCATGA GGCCCTCGAA CATCTGAAGA AAGAGCAAGA AGAGGCCTGG 
AAGCTTGAAG TTGGTGAAAG GAAACGAACT GCCACCTGGA AGATACAGGT GGAAACCCGA 
AAACAGAGTA TTGTATGGGA GTTTGAAAAA TACCAGCGAT TACTAGAGAA AAAGCAGCCA 
CCACATCGGC AGCTGGGGGC AGAGGTAGCA GCAGCTCTGG CCAGCCTACA GCGGGAGGCA 
GCGGAGACCA TGCAGAAACT GGAGTTGAAC CATAGCGAGC TCATCCAGCA GAGCCAGGTC 
CTGTGGAGGA TGATTGCAGA GTTGAAAGAG AGGTCGCAGA GGCCTGTCCG CTGGATGTTG 
CAGGATATTC AGGAAGTGTT AAACAGGAGC AAATCTTGGA GCTTGCAGCA GCCAGAACCA 
ATCTCCCTGG AGTTGAAGAC AGATTGCCGT GTGCTGGGGC TAAGAGAGAT CCTGAAGACT 
TATGCAGCTG ATGTGCGCTT GGATCCAGAT ACTGCTTACT CCCGTCTCAT CGTGTCTGAG 
GACAGAAAAC GTGTGCACTA TGGAGACACC AACCAGAAAC TGCCAGACAA TCCTGAGAGA 
TTTTACCGCT ATAATATCGT CCTGGGAAGC CAGTGCATCT CCTCAGGCCG GCACTACTGG 
GAGGTGGAGG TGGGAGACAG GTCTGAGTGG GGCCTGGGAG TATGTAAGCA AAATGTAGAC 
CGGAAGGAGG TGGTCTACTT ATCCCCCCAC TATGGATTCT GGGTGATAAG GCTGAGGAAG 
GGAAATGAGT ACCGAGCAGG CACCGATGAG TACCCAATCC TGTCCTTGCC GGTCCCTCCT 
CGCCGGGTGG GAATCTTCGT GGATTATGAG GCCCATGACA TTTCTTTCTA CAATGTGACT 
GACTGTGGCT CCCACATCTT CACTTTCCCC CGCTATCCCT TCCCTGGGCG CCTCCTGCCC 
TATTTTAGTC CTTGCTACAG CATTGGAACC AACAACACTG CTCCTCTGGC CATCTGCTCC 
CTGGATGGGG AGGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060543.5
CDS	291..1748
Translation	MDPTALVEAIVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQNWGYTCPLCRAPVQPRNLRPNWQLANVVEKVRLLRLHPGMGLKGDLCERHGEKLKMFCKEDVLIMCEACSQSPEHEAHSVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTATWKIQVETRKQSIVWEFEKYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELIQQSQVLWRMIAELKERSQRPVRWMLQDIQEVLNRSKSWSLQQPEPISLELKTDCRVLGLREILKTYAADVRLDPDTAYSRLIVSEDRKRVHYGDTNQKLPDNPERFYRYNIVLGSQCISSGRHYWEVEVGDRSEWGLGVCKQNVDRKEVVYLSPHYGFWVIRLRKGNEYRAGTDEYPILSLPVPPRRVGIFVDYEAHDISFYNVTDCGSHIFTFPRYPFPGRLLPYFSPCYSIGTNNTAPLAICSLDGED

Target ORF information:

RefSeq Version	NM_018073.7
Organism	Homo sapiens(human)
Definition	Homo sapiens tripartite motif containing 68 (TRIM68), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018073.7

ORF Insert Sequence:

ATGGATCCCA CAGCCTTGGT GGAAGCCATT GTGGAAGAAG TGGCCTGTCC CATCTGTATG 
ACCTTCCTGA GGGAGCCCAT GAGCATTGAC TGTGGCCACA GCTTCTGCCA CAGCTGTCTC 
TCTGGACTCT GGGAGATCCC AGGAGAATCC CAGAACTGGG GTTACACCTG TCCCCTCTGT 
CGAGCTCCTG TCCAGCCAAG GAACCTGCGG CCTAATTGGC AGCTGGCCAA TGTTGTAGAA 
AAAGTCCGTC TGCTAAGGCT ACATCCAGGA ATGGGGCTGA AGGGTGACCT GTGTGAGCGC 
CATGGGGAAA AGCTGAAGAT GTTCTGCAAA GAGGATGTCT TGATAATGTG TGAGGCCTGC 
AGCCAGTCCC CAGAGCATGA GGCCCACAGT GTTGTGCCAA TGGAGGATGT TGCCTGGGAG 
TACAAGTGGG AACTTCATGA GGCCCTCGAA CATCTGAAGA AAGAGCAAGA AGAGGCCTGG 
AAGCTTGAAG TTGGTGAAAG GAAACGAACT GCCACCTGGA AGATACAGGT GGAAACCCGA 
AAACAGAGTA TTGTATGGGA GTTTGAAAAA TACCAGCGAT TACTAGAGAA AAAGCAGCCA 
CCACATCGGC AGCTGGGGGC AGAGGTAGCA GCAGCTCTGG CCAGCCTACA GCGGGAGGCA 
GCGGAGACCA TGCAGAAACT GGAGTTGAAC CATAGCGAGC TCATCCAGCA GAGCCAGGTC 
CTGTGGAGGA TGATTGCAGA GTTGAAAGAG AGGTCGCAGA GGCCTGTCCG CTGGATGTTG 
CAGGATATTC AGGAAGTGTT AAACAGGAGC AAATCTTGGA GCTTGCAGCA GCCAGAACCA 
ATCTCCCTGG AGTTGAAGAC AGATTGCCGT GTGCTGGGGC TAAGAGAGAT CCTGAAGACT 
TATGCAGCTG ATGTGCGCTT GGATCCAGAT ACTGCTTACT CCCGTCTCAT CGTGTCTGAG 
GACAGAAAAC GTGTGCACTA TGGAGACACC AACCAGAAAC TGCCAGACAA TCCTGAGAGA 
TTTTACCGCT ATAATATCGT CCTGGGAAGC CAGTGCATCT CCTCAGGCCG GCACTACTGG 
GAGGTGGAGG TGGGAGACAG GTCTGAGTGG GGCCTGGGAG TATGTAAGCA AAATGTAGAC 
CGGAAGGAGG TGGTCTACTT ATCCCCCCAC TATGGATTCT GGGTGATAAG GCTGAGGAAG 
GGAAATGAGT ACCGAGCAGG CACCGATGAG TACCCAATCC TGTCCTTGCC GGTCCCTCCT 
CGCCGGGTGG GAATCTTCGT GGATTATGAG GCCCATGACA TTTCTTTCTA CAATGTGACT 
GACTGTGGCT CCCACATCTT CACTTTCCCC CGCTATCCCT TCCCTGGGCG CCTCCTGCCC 
TATTTTAGTC CTTGCTACAG CATTGGAACC AACAACACTG CTCCTCTGGC CATCTGCTCC 
CTGGATGGGG AGGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TRIM68 ( NM_001304496.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001291425.1 Homo sapiens tripartite motif containing 68 (TRIM68), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu69025
Clone ID Related Accession (Same CDS sequence)	NM_001304496.1 , NM_001304496.2
Accession Version	NM_001304496.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 789bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-29
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase TRIM68 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC402744.1, DA833140.1, AC090719.8, AK022923.1 and AL832730.1. Transcript Variant: This variant (2) lacks an exon in the 5' coding region compared to variant 1. The encoded isoform (2) uses a downstream start codon and has a shorter N-terminus compared to isoform (1). ##Evidence-Data-START## Transcript exon combination :: SRR1660803.136381.1, DA833140.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGAAAC TGGAGTTGAA CCATAGCGAG CTCATCCAGC AGAGCCAGGT CCTGTGGAGG 
ATGATTGCAG AGTTGAAAGA GAGGTCGCAG AGGCCTGTCC GCTGGATGTT GCAGGATATT 
CAGGAAGTGT TAAACAGGAG CAAATCTTGG AGCTTGCAGC AGCCAGAACC AATCTCCCTG 
GAGTTGAAGA CAGATTGCCG TGTGCTGGGG CTAAGAGAGA TCCTGAAGAC TTATGCAGCT 
GATGTGCGCT TGGATCCAGA TACTGCTTAC TCCCGTCTCA TCGTGTCTGA GGACAGAAAA 
CGTGTGCACT ATGGAGACAC CAACCAGAAA CTGCCAGACA ATCCTGAGAG ATTTTACCGC 
TATAATATCG TCCTGGGAAG CCAGTGCATC TCCTCAGGCC GGCACTACTG GGAGGTGGAG 
GTGGGAGACA GGTCTGAGTG GGGCCTGGGA GTATGTAAGC AAAATGTAGA CCGGAAGGAG 
GTGGTCTACT TATCCCCCCA CTATGGATTC TGGGTGATAA GGCTGAGGAA GGGAAATGAG 
TACCGAGCAG GCACCGATGA GTACCCAATC CTGTCCTTGC CGGTCCCTCC TCGCCGGGTG 
GGAATCTTCG TGGATTATGA GGCCCATGAC ATTTCTTTCT ACAATGTGAC TGACTGTGGC 
TCCCACATCT TCACTTTCCC CCGCTATCCC TTCCCTGGGC GCCTCCTGCC CTATTTTAGT 
CCTTGCTACA GCATTGGAAC CAACAACACT GCTCCTCTGG CCATCTGCTC CCTGGATGGG 
GAGGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001291425.1
CDS	477..1265
Translation	MQKLELNHSELIQQSQVLWRMIAELKERSQRPVRWMLQDIQEVLNRSKSWSLQQPEPISLELKTDCRVLGLREILKTYAADVRLDPDTAYSRLIVSEDRKRVHYGDTNQKLPDNPERFYRYNIVLGSQCISSGRHYWEVEVGDRSEWGLGVCKQNVDRKEVVYLSPHYGFWVIRLRKGNEYRAGTDEYPILSLPVPPRRVGIFVDYEAHDISFYNVTDCGSHIFTFPRYPFPGRLLPYFSPCYSIGTNNTAPLAICSLDGED

Target ORF information:

RefSeq Version	NM_001304496.1
Organism	Homo sapiens(human)
Definition	Homo sapiens tripartite motif containing 68 (TRIM68), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001304496.1

ORF Insert Sequence:

ATGCAGAAAC TGGAGTTGAA CCATAGCGAG CTCATCCAGC AGAGCCAGGT CCTGTGGAGG 
ATGATTGCAG AGTTGAAAGA GAGGTCGCAG AGGCCTGTCC GCTGGATGTT GCAGGATATT 
CAGGAAGTGT TAAACAGGAG CAAATCTTGG AGCTTGCAGC AGCCAGAACC AATCTCCCTG 
GAGTTGAAGA CAGATTGCCG TGTGCTGGGG CTAAGAGAGA TCCTGAAGAC TTATGCAGCT 
GATGTGCGCT TGGATCCAGA TACTGCTTAC TCCCGTCTCA TCGTGTCTGA GGACAGAAAA 
CGTGTGCACT ATGGAGACAC CAACCAGAAA CTGCCAGACA ATCCTGAGAG ATTTTACCGC 
TATAATATCG TCCTGGGAAG CCAGTGCATC TCCTCAGGCC GGCACTACTG GGAGGTGGAG 
GTGGGAGACA GGTCTGAGTG GGGCCTGGGA GTATGTAAGC AAAATGTAGA CCGGAAGGAG 
GTGGTCTACT TATCCCCCCA CTATGGATTC TGGGTGATAA GGCTGAGGAA GGGAAATGAG 
TACCGAGCAG GCACCGATGA GTACCCAATC CTGTCCTTGC CGGTCCCTCC TCGCCGGGTG 
GGAATCTTCG TGGATTATGA GGCCCATGAC ATTTCTTTCT ACAATGTGAC TGACTGTGGC 
TCCCACATCT TCACTTTCCC CCGCTATCCC TTCCCTGGGC GCCTCCTGCC CTATTTTAGT 
CCTTGCTACA GCATTGGAAC CAACAACACT GCTCCTCTGG CCATCTGCTC CCTGGATGGG 
GAGGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TRIM68 ( NM_001304496.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001291425.1 Homo sapiens tripartite motif containing 68 (TRIM68), transcript variant 2, mRNA.

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CloneID	OHu69025
Clone ID Related Accession (Same CDS sequence)	NM_001304496.1 , NM_001304496.2
Accession Version	NM_001304496.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 789bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-08
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase TRIM68 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC090719.8. On Jun 1, 2019 this sequence version replaced NM_001304496.1. Transcript Variant: This variant (2) lacks an exon in the 5' coding region compared to variant 1. The encoded isoform (2) uses a downstream start codon and has a shorter N-terminus compared to isoform (1). ##Evidence-Data-START## Transcript exon combination :: SRR1660803.136381.1, DA833140.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGAAAC TGGAGTTGAA CCATAGCGAG CTCATCCAGC AGAGCCAGGT CCTGTGGAGG 
ATGATTGCAG AGTTGAAAGA GAGGTCGCAG AGGCCTGTCC GCTGGATGTT GCAGGATATT 
CAGGAAGTGT TAAACAGGAG CAAATCTTGG AGCTTGCAGC AGCCAGAACC AATCTCCCTG 
GAGTTGAAGA CAGATTGCCG TGTGCTGGGG CTAAGAGAGA TCCTGAAGAC TTATGCAGCT 
GATGTGCGCT TGGATCCAGA TACTGCTTAC TCCCGTCTCA TCGTGTCTGA GGACAGAAAA 
CGTGTGCACT ATGGAGACAC CAACCAGAAA CTGCCAGACA ATCCTGAGAG ATTTTACCGC 
TATAATATCG TCCTGGGAAG CCAGTGCATC TCCTCAGGCC GGCACTACTG GGAGGTGGAG 
GTGGGAGACA GGTCTGAGTG GGGCCTGGGA GTATGTAAGC AAAATGTAGA CCGGAAGGAG 
GTGGTCTACT TATCCCCCCA CTATGGATTC TGGGTGATAA GGCTGAGGAA GGGAAATGAG 
TACCGAGCAG GCACCGATGA GTACCCAATC CTGTCCTTGC CGGTCCCTCC TCGCCGGGTG 
GGAATCTTCG TGGATTATGA GGCCCATGAC ATTTCTTTCT ACAATGTGAC TGACTGTGGC 
TCCCACATCT TCACTTTCCC CCGCTATCCC TTCCCTGGGC GCCTCCTGCC CTATTTTAGT 
CCTTGCTACA GCATTGGAAC CAACAACACT GCTCCTCTGG CCATCTGCTC CCTGGATGGG 
GAGGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001291425.1
CDS	449..1237
Translation	MQKLELNHSELIQQSQVLWRMIAELKERSQRPVRWMLQDIQEVLNRSKSWSLQQPEPISLELKTDCRVLGLREILKTYAADVRLDPDTAYSRLIVSEDRKRVHYGDTNQKLPDNPERFYRYNIVLGSQCISSGRHYWEVEVGDRSEWGLGVCKQNVDRKEVVYLSPHYGFWVIRLRKGNEYRAGTDEYPILSLPVPPRRVGIFVDYEAHDISFYNVTDCGSHIFTFPRYPFPGRLLPYFSPCYSIGTNNTAPLAICSLDGED

Target ORF information:

RefSeq Version	NM_001304496.2
Organism	Homo sapiens(human)
Definition	Homo sapiens tripartite motif containing 68 (TRIM68), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001304496.2

ORF Insert Sequence:

ATGCAGAAAC TGGAGTTGAA CCATAGCGAG CTCATCCAGC AGAGCCAGGT CCTGTGGAGG 
ATGATTGCAG AGTTGAAAGA GAGGTCGCAG AGGCCTGTCC GCTGGATGTT GCAGGATATT 
CAGGAAGTGT TAAACAGGAG CAAATCTTGG AGCTTGCAGC AGCCAGAACC AATCTCCCTG 
GAGTTGAAGA CAGATTGCCG TGTGCTGGGG CTAAGAGAGA TCCTGAAGAC TTATGCAGCT 
GATGTGCGCT TGGATCCAGA TACTGCTTAC TCCCGTCTCA TCGTGTCTGA GGACAGAAAA 
CGTGTGCACT ATGGAGACAC CAACCAGAAA CTGCCAGACA ATCCTGAGAG ATTTTACCGC 
TATAATATCG TCCTGGGAAG CCAGTGCATC TCCTCAGGCC GGCACTACTG GGAGGTGGAG 
GTGGGAGACA GGTCTGAGTG GGGCCTGGGA GTATGTAAGC AAAATGTAGA CCGGAAGGAG 
GTGGTCTACT TATCCCCCCA CTATGGATTC TGGGTGATAA GGCTGAGGAA GGGAAATGAG 
TACCGAGCAG GCACCGATGA GTACCCAATC CTGTCCTTGC CGGTCCCTCC TCGCCGGGTG 
GGAATCTTCG TGGATTATGA GGCCCATGAC ATTTCTTTCT ACAATGTGAC TGACTGTGGC 
TCCCACATCT TCACTTTCCC CCGCTATCCC TTCCCTGGGC GCCTCCTGCC CTATTTTAGT 
CCTTGCTACA GCATTGGAAC CAACAACACT GCTCCTCTGG CCATCTGCTC CCTGGATGGG 
GAGGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TRIM68 negatively regulates IFN-? production by degrading TRK fused gene, a novel driver of IFN-? downstream of anti-viral detection systems.
PloS one9(7)e101503(2014)
Wynne C,Lazzari E,Smith S,McCarthy EM,N? Gabhann J,Kallal LE,Higgs R,Greco A,Cryan SA,Biron CA,Jefferies CA

Epigenetic deregulation of miR-29a and miR-1256 by isoflavone contributes to the inhibition of prostate cancer cell growth and invasion.
Epigenetics7(8)940-9(2012 Aug)
Li Y,Kong D,Ahmad A,Bao B,Dyson G,Sarkar FH

TRIM proteins and cancer.
Nature reviews. Cancer11(11)792-804(2011 10)
Hatakeyama S

Melanoma inhibitor of apoptosis protein (ML-IAP) specific cytotoxic T lymphocytes cross-react with an epitope from the auto-antigen SS56.
The Journal of investigative dermatology129(8)1992-9(2009 Aug)
Baek S?rensen R,Faurschou M,Troelsen L,Schrama D,Jacobsen S,Becker JC,Thor Straten P,Andersen MH

TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells.
Cancer research68(9)3486-94(2008 May)
Miyajima N,Maruyama S,Bohgaki M,Kano S,Shigemura M,Shinohara N,Nonomura K,Hatakeyama S

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TRIM68 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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