MOCOS cDNA ORF clone, Homo sapiens(Human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MOCOS
Entrez Gene ID	55034
Full Name	molybdenum cofactor sulfurase
Synonyms	HMCS,MCS,MOS
General protein information	Preferred Names molybdenum cofactor sulfurase Names molybdenum cofactor sulfurase
Gene Type	protein-coding
Organism	Homo sapiens(Human)
Genome	Chromosome: 18 Map Location: 18q12.2
Summary	This gene encodes an enzyme that sulfurates the molybdenum cofactor which is required for activation of the xanthine dehydrogenase (XDH) and aldehyde oxidase (AO) enzymes. XDH catalyzes the conversion of hypoxanthine to uric acid via xanthine, as well as the conversion of allopurinol to oxypurinol, and pyrazinamide to 5-hydroxy pyrazinamide. Mutations in this gene cause the metabolic disorder classical xanthinuria type II which is characterized by the loss of XDH/XO and AO enzyme activity, decreased levels of uric acid in the urine, increased levels of xanthine and hypoxanthine in the serum and urine, formation of xanthine stones in the urinary tract, and myositis due to tissue deposition of xanthine. [provided by RefSeq, Apr 2017].
Disorder MIM:	613274
Disorder Html:	Xanthinuria, type II, 603592 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_017947.4	NP_060417.4	molybdenum cofactor sulfurase
NM_017947.3	NP_060417.3	molybdenum cofactor sulfurase
NM_017947.2	NP_060417.2	molybdenum cofactor sulfurase

Pathways from BioSystems

Homologies

Homo sapiens (human)	MOCOS	NP_060417.2
Danio rerio (zebrafish)	mocos	NP_001014388.2
Anopheles gambiae (African malaria mosquito)	MOCOS_ANOGA	XP_310528.5
Arabidopsis thaliana (thale cress)	ABA3	NP_564001.1
Bos taurus (cattle)	MOCOS	NP_776506.1
Caenorhabditis elegans (roundworm)	mocs-1	NP_510552.2
Gallus gallus (chicken)	MOCOS	XP_419048.4
Drosophila melanogaster (fruit fly)	mal	NP_523423.1
Pan troglodytes (chimpanzee)	MOCOS	XP_512097.2
Rattus norvegicus (Norway rat)	Mocos	NP_001101895.1
	MOCOS	XP_001105941.1
Canis lupus familiaris (dog)	MOCOS	XP_547604.4
Mus musculus (house mouse)	Mocos	NP_081055.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Polymorphism of genes involved in purine metabolism (XDH, AOX1, MOCOS) in kidney transplant recipients receiving azathioprine.
Kurzawski M, Dziewanowski K, Safranow K, Drozdzik M
Therapeutic drug monitoring34(3)266-74(2012 Jun)

Next-generation sequencing to generate interactome datasets.
Yu H, Tardivo L, Tam S, Weiner E, Gebreab F, Fan C, Svrzikapa N, Hirozane-Kishikawa T, Rietman E, Yang X, Sahalie J, Salehi-Ashtiani K, Hao T, Cusick ME, Hill DE, Roth FP, Braun P, Vidal M
Nature methods8(6)478-80(2011 Jun)

Novel pharmacogenetic markers for treatment outcome in azathioprine-treated inflammatory bowel disease.
Smith MA, Marinaki AM, Arenas M, Shobowale-Bakre M, Lewis CM, Ansari A, Duley J, Sanderson JD
Alimentary pharmacology & therapeutics30(4)375-84(2009 Aug)

Identification and characterization of the first mutation (Arg776Cys) in the C-terminal domain of the Human Molybdenum Cofactor Sulfurase (HMCS) associated with type II classical xanthinuria.
Peretz H, Naamati MS, Levartovsky D, Lagziel A, Shani E, Horn I, Shalev H, Landau D
Molecular genetics and metabolism91(1)23-9(2007 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MOCOS sulfurates the molybdenum cofactor of xanthine oxidase (XDH) and aldehyde oxidase 1 (AOX1), which is required for their activities.
Title: Polymorphism of genes involved in purine metabolism (XDH, AOX1, MOCOS) in kidney transplant recipients receiving azathioprine.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Novel pharmacogenetic markers for treatment outcome in azathioprine-treated inflammatory bowel disease.

Two mutations, both in the N-terminal domain of the Human Molybdenum Cofactor Sulfurase (HMCS), were reported in patients with type II xanthinuria.
Title: Identification and characterization of the first mutation (Arg776Cys) in the C-terminal domain of the Human Molybdenum Cofactor Sulfurase (HMCS) associated with type II classical xanthinuria.

The following MOCOS gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MOCOS cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02633	NM_017947.4 Latest version!	Homo sapiens molybdenum cofactor sulfurase (MOCOS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu102433	NM_017947.3 Latest version!	Homo sapiens molybdenum cofactor sulfurase (MOCOS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	10-12	$475.30 $679.00
View Old Accession Versions >>
OHu02633	NM_017947.2	Homo sapiens molybdenum cofactor sulfurase (MOCOS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MOCOS ( NM_017947.4 ) cDNA ORF clone, Homo sapiens(Human) -> NP_060417.4 Homo sapiens molybdenum cofactor sulfurase (MOCOS), mRNA.

Price & Availability↑

CloneID	OHu02633
Clone ID Related Accession (Same CDS sequence)	NM_017947.4 , NM_017947.2
Accession Version	NM_017947.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2667bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	molybdenum cofactor sulfurase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC023043.8. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_017947.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK000740.1, AK222886.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000261326.6/ ENSP00000261326.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCGGCG CGGCGGCGGA GTCAGGGCGG GAGCTGTGGA CCTTCGCGGG TTCCCGGGAC 
CCGAGCGCAC CGCGGCTAGC CTACGGCTAC GGCCCGGGCA GCCTGCGCGA GCTGCGGGCG 
CGCGAGTTCA GCCGCCTGGC AGGAACTGTC TATCTTGACC ATGCAGGTGC CACCTTGTTC 
TCCCAGAGCC AGCTCGAAAG CTTCACTAGT GATCTCATGG AAAACACTTA TGGTAATCCT 
CACAGCCAGA ACATCAGCAG CAAGCTCACC CATGACACTG TGGAGCAGGT GCGCTACAGA 
ATCCTGGCGC ACTTCCACAC CACCGCAGAA GACTACACTG TGATCTTCAC TGCCGGGAGC 
ACGGCTGCTC TCAAACTGGT GGCAGAGGCC TTTCCATGGG TGTCCCAGGG CCCAGAGAGC 
AGTGGGAGTC GCTTCTGTTA CCTCACCGAC AGCCACACCT CCGTAGTGGG TATGCGGAAC 
GTGACCATGG CTATAAATGT CATATCCACC CCGGTCAGGC CAGAGGACCT GTGGTCTGCA 
GAGGAACGTA GTGCTTCAGC CAGCAACCCA GACTGCCAGC TGCCGCATCT CTTCTGCTAC 
CCAGCTCAGA GTAACTTTTC TGGAGTCAGA TACCCCCTGT CCTGGATAGA AGAGGTCAAG 
TCTGGGCGGT TGCACCCTGT GAGCACGCCT GGGAAGTGGT TTGTGCTGCT GGATGCAGCC 
TCCTACGTGA GCACCTCGCC TTTGGACCTG TCAGCTCACC AGGCCGACTT TGTCCCCATC 
TCCTTCTATA AGATCTTCGG GTTTCCTACA GGCCTGGGCG CTCTGCTGGT CCATAATCGT 
GCGGCTCCTC TACTGAGGAA GACCTACTTT GGAGGAGGGA CAGCCTCTGC GTACCTAGCA 
GGAGAAGACT TCTACATCCC GAGGCAGTCG GTAGCTCAGA GGTTTGAAGA TGGCACCATC 
TCATTCCTTG ATGTTATCGC GCTAAAACAT GGATTTGACA CCCTAGAGCG CCTCACAGGT 
GGAATGGAGA ATATAAAGCA GCACACCTTC ACCTTGGCTC AGTATACCTA CGTGGCCCTG 
TCCTCTCTCC AGTACCCCAA TGGAGCCCCT GTGGTGCGGA TTTACAGCGA TTCTGAGTTC 
AGCAGCCCTG AGGTTCAGGG CCCAATCATC AATTTTAATG TGCTGGATGA CAAAGGGAAC 
ATCATTGGTT ACTCCCAGGT GGACAAAATG GCCAGTCTTT ACAACATCCA CCTGCGAACT 
GGCTGCTTCT GTAACACTGG GGCCTGCCAG AGGCACCTGG GCATAAGCAA CGAGATGGTC 
AGGAAGCATT TTCAGGCTGG TCATGTCTGT GGGGACAATA TGGACCTCAT AGATGGGCAG 
CCCACAGGAT CTGTGAGGAT TTCATTTGGA TACATGTCGA CGCTGGATGA TGTCCAGGCC 
TTTCTTAGGT TCATCATAGA CACTCGCCTG CACTCATCAG GGGACTGGCC TGTCCCTCAG 
GCCCATGCTG ACACCGGGGA GACTGGAGCC CCATCAGCAG ACAGCCAGGC TGATGTTATA 
CCTGCTGTCA TGGGCAGACG TAGCCTCTCG CCTCAGGAAG ATGCCCTCAC AGGCTCCAGG 
GTTTGGAACA ACTCGTCTAC TGTGAATGCT GTGCCTGTGG CCCCACCTGT GTGTGATGTC 
GCCAGAACCC AGCCGACTCC TTCAGAGAAA GCTGCAGGAG TCCTGGAGGG GGCCCTTGGG 
CCACATGTTG TCACTAACCT TTATCTCTAT CCAATCAAAT CCTGTGCTGC ATTTGAGGTG 
ACCAGGTGGC CTGTAGGAAA CCAAGGGCTG CTATATGACC GGAGCTGGAT GGTTGTGAAT 
CACAATGGTG TTTGCCTGAG TCAGAAGCAG GAACCCCGGC TCTGCCTGAT CCAGCCCTTC 
ATCGACTTGC GGCAAAGGAT CATGGTCATC AAAGCCAAAG GGATGGAGCC TATAGAGGTG 
CCTCTTGAGG AAAATAGTGA ACGGACTCAG ATTCGCCAAA GCAGGGTCTG TGCTGACAGA 
GTAAGTACTT ATGATTGTGG AGAAAAAATT TCAAGCTGGT TGTCAACATT TTTTGGCCGT 
CCTTGTCATT TGATCAAACA AAGTTCAAAC TCTCAAAGGA ATGCAAAGAA GAAACATGGA 
AAAGATCAAC TTCCTGGTAC AATGGCCACC CTTTCTCTGG TGAATGAGGC ACAGTATCTG 
CTGATCAACA CATCCAGTAT TTTGGAACTT CACCGGCAAC TAAACACCAG TGATGAGAAT 
GGAAAGGAGG AATTATTCTC ACTGAAGGAT CTCAGCTTGC GTTTTCGTGC CAATATTATT 
ATCAATGGAA AAAGGGCTTT TGAAGAAGAG AAATGGGATG AGATTTCAAT TGGCTCTTTG 
CGTTTCCAGG TTTTGGGGCC TTGTCACAGA TGCCAGATGA TTTGCATCGA CCAGCAAACT 
GGGCAACGAA ACCAGCATGT TTTCCAAAAA CTTTCTGAGA GTCGTGAAAC AAAGGTGAAC 
TTTGGCATGT ACCTGATGCA TGCATCATTG GATTTATCCT CCCCATGTTT CCTGTCTGTA 
GGATCTCAGG TGCTCCCTGT GTTGAAAGAG AATGTGGAAG GTCATGATTT ACCTGCATCT 
GAGAAACACC AGGATGTTAC CTCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060417.4
CDS	44..2710
Translation	MAGAAAESGRELWTFAGSRDPSAPRLAYGYGPGSLRELRAREFSRLAGTVYLDHAGATLFSQSQLESFTSDLMENTYGNPHSQNISSKLTHDTVEQVRYRILAHFHTTAEDYTVIFTAGSTAALKLVAEAFPWVSQGPESSGSRFCYLTDSHTSVVGMRNVTMAINVISTPVRPEDLWSAEERSASASNPDCQLPHLFCYPAQSNFSGVRYPLSWIEEVKSGRLHPVSTPGKWFVLLDAASYVSTSPLDLSAHQADFVPISFYKIFGFPTGLGALLVHNRAAPLLRKTYFGGGTASAYLAGEDFYIPRQSVAQRFEDGTISFLDVIALKHGFDTLERLTGGMENIKQHTFTLAQYTYVALSSLQYPNGAPVVRIYSDSEFSSPEVQGPIINFNVLDDKGNIIGYSQVDKMASLYNIHLRTGCFCNTGACQRHLGISNEMVRKHFQAGHVCGDNMDLIDGQPTGSVRISFGYMSTLDDVQAFLRFIIDTRLHSSGDWPVPQAHADTGETGAPSADSQADVIPAVMGRRSLSPQEDALTGSRVWNNSSTVNAVPVAPPVCDVARTQPTPSEKAAGVLEGALGPHVVTNLYLYPIKSCAAFEVTRWPVGNQGLLYDRSWMVVNHNGVCLSQKQEPRLCLIQPFIDLRQRIMVIKAKGMEPIEVPLEENSERTQIRQSRVCADRVSTYDCGEKISSWLSTFFGRPCHLIKQSSNSQRNAKKKHGKDQLPGTMATLSLVNEAQYLLINTSSILELHRQLNTSDENGKEELFSLKDLSLRFRANIIINGKRAFEEEKWDEISIGSLRFQVLGPCHRCQMICIDQQTGQRNQHVFQKLSESRETKVNFGMYLMHASLDLSSPCFLSVGSQVLPVLKENVEGHDLPASEKHQDVTS

Target ORF information:

RefSeq Version	NM_017947.4
Organism	Homo sapiens(human)
Definition	Homo sapiens molybdenum cofactor sulfurase (MOCOS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017947.4

ORF Insert Sequence:

ATGGCCGGCG CGGCGGCGGA GTCAGGGCGG GAGCTGTGGA CCTTCGCGGG TTCCCGGGAC 
CCGAGCGCAC CGCGGCTAGC CTACGGCTAC GGCCCGGGCA GCCTGCGCGA GCTGCGGGCG 
CGCGAGTTCA GCCGCCTGGC AGGAACTGTC TATCTTGACC ATGCAGGTGC CACCTTGTTC 
TCCCAGAGCC AGCTCGAAAG CTTCACTAGT GATCTCATGG AAAACACTTA TGGTAATCCT 
CACAGCCAGA ACATCAGCAG CAAGCTCACC CATGACACTG TGGAGCAGGT GCGCTACAGA 
ATCCTGGCGC ACTTCCACAC CACCGCAGAA GACTACACTG TGATCTTCAC TGCCGGGAGC 
ACGGCTGCTC TCAAACTGGT GGCAGAGGCC TTTCCATGGG TGTCCCAGGG CCCAGAGAGC 
AGTGGGAGTC GCTTCTGTTA CCTCACCGAC AGCCACACCT CCGTAGTGGG TATGCGGAAC 
GTGACCATGG CTATAAATGT CATATCCACC CCGGTCAGGC CAGAGGACCT GTGGTCTGCA 
GAGGAACGTA GTGCTTCAGC CAGCAACCCA GACTGCCAGC TGCCGCATCT CTTCTGCTAC 
CCAGCTCAGA GTAACTTTTC TGGAGTCAGA TACCCCCTGT CCTGGATAGA AGAGGTCAAG 
TCTGGGCGGT TGCACCCTGT GAGCACGCCT GGGAAGTGGT TTGTGCTGCT GGATGCAGCC 
TCCTACGTGA GCACCTCGCC TTTGGACCTG TCAGCTCACC AGGCCGACTT TGTCCCCATC 
TCCTTCTATA AGATCTTCGG GTTTCCTACA GGCCTGGGCG CTCTGCTGGT CCATAATCGT 
GCGGCTCCTC TACTGAGGAA GACCTACTTT GGAGGAGGGA CAGCCTCTGC GTACCTAGCA 
GGAGAAGACT TCTACATCCC GAGGCAGTCG GTAGCTCAGA GGTTTGAAGA TGGCACCATC 
TCATTCCTTG ATGTTATCGC GCTAAAACAT GGATTTGACA CCCTAGAGCG CCTCACAGGT 
GGAATGGAGA ATATAAAGCA GCACACCTTC ACCTTGGCTC AGTATACCTA CGTGGCCCTG 
TCCTCTCTCC AGTACCCCAA TGGAGCCCCT GTGGTGCGGA TTTACAGCGA TTCTGAGTTC 
AGCAGCCCTG AGGTTCAGGG CCCAATCATC AATTTTAATG TGCTGGATGA CAAAGGGAAC 
ATCATTGGTT ACTCCCAGGT GGACAAAATG GCCAGTCTTT ACAACATCCA CCTGCGAACT 
GGCTGCTTCT GTAACACTGG GGCCTGCCAG AGGCACCTGG GCATAAGCAA CGAGATGGTC 
AGGAAGCATT TTCAGGCTGG TCATGTCTGT GGGGACAATA TGGACCTCAT AGATGGGCAG 
CCCACAGGAT CTGTGAGGAT TTCATTTGGA TACATGTCGA CGCTGGATGA TGTCCAGGCC 
TTTCTTAGGT TCATCATAGA CACTCGCCTG CACTCATCAG GGGACTGGCC TGTCCCTCAG 
GCCCATGCTG ACACCGGGGA GACTGGAGCC CCATCAGCAG ACAGCCAGGC TGATGTTATA 
CCTGCTGTCA TGGGCAGACG TAGCCTCTCG CCTCAGGAAG ATGCCCTCAC AGGCTCCAGG 
GTTTGGAACA ACTCGTCTAC TGTGAATGCT GTGCCTGTGG CCCCACCTGT GTGTGATGTC 
GCCAGAACCC AGCCGACTCC TTCAGAGAAA GCTGCAGGAG TCCTGGAGGG GGCCCTTGGG 
CCACATGTTG TCACTAACCT TTATCTCTAT CCAATCAAAT CCTGTGCTGC ATTTGAGGTG 
ACCAGGTGGC CTGTAGGAAA CCAAGGGCTG CTATATGACC GGAGCTGGAT GGTTGTGAAT 
CACAATGGTG TTTGCCTGAG TCAGAAGCAG GAACCCCGGC TCTGCCTGAT CCAGCCCTTC 
ATCGACTTGC GGCAAAGGAT CATGGTCATC AAAGCCAAAG GGATGGAGCC TATAGAGGTG 
CCTCTTGAGG AAAATAGTGA ACGGACTCAG ATTCGCCAAA GCAGGGTCTG TGCTGACAGA 
GTAAGTACTT ATGATTGTGG AGAAAAAATT TCAAGCTGGT TGTCAACATT TTTTGGCCGT 
CCTTGTCATT TGATCAAACA AAGTTCAAAC TCTCAAAGGA ATGCAAAGAA GAAACATGGA 
AAAGATCAAC TTCCTGGTAC AATGGCCACC CTTTCTCTGG TGAATGAGGC ACAGTATCTG 
CTGATCAACA CATCCAGTAT TTTGGAACTT CACCGGCAAC TAAACACCAG TGATGAGAAT 
GGAAAGGAGG AATTATTCTC ACTGAAGGAT CTCAGCTTGC GTTTTCGTGC CAATATTATT 
ATCAATGGAA AAAGGGCTTT TGAAGAAGAG AAATGGGATG AGATTTCAAT TGGCTCTTTG 
CGTTTCCAGG TTTTGGGGCC TTGTCACAGA TGCCAGATGA TTTGCATCGA CCAGCAAACT 
GGGCAACGAA ACCAGCATGT TTTCCAAAAA CTTTCTGAGA GTCGTGAAAC AAAGGTGAAC 
TTTGGCATGT ACCTGATGCA TGCATCATTG GATTTATCCT CCCCATGTTT CCTGTCTGTA 
GGATCTCAGG TGCTCCCTGT GTTGAAAGAG AATGTGGAAG GTCATGATTT ACCTGCATCT 
GAGAAACACC AGGATGTTAC CTCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MOCOS ( NM_017947.2 ) cDNA ORF clone, Homo sapiens(Human) -> NP_060417.2 Homo sapiens molybdenum cofactor sulfurase (MOCOS), mRNA.

Price & Availability↑

CloneID	OHu02633
Clone ID Related Accession (Same CDS sequence)	NM_017947.4 , NM_017947.2
Accession Version	NM_017947.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2667bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	molybdenum cofactor sulfurase
Comment

ATGGCCGGCG CGGCGGCGGA GTCAGGGCGG GAGCTGTGGA CCTTCGCGGG TTCCCGGGAC 
CCGAGCGCAC CGCGGCTAGC CTACGGCTAC GGCCCGGGCA GCCTGCGCGA GCTGCGGGCG 
CGCGAGTTCA GCCGCCTGGC AGGAACTGTC TATCTTGACC ATGCAGGTGC CACCTTGTTC 
TCCCAGAGCC AGCTCGAAAG CTTCACTAGT GATCTCATGG AAAACACTTA TGGTAATCCT 
CACAGCCAGA ACATCAGCAG CAAGCTCACC CATGACACTG TGGAGCAGGT GCGCTACAGA 
ATCCTGGCGC ACTTCCACAC CACCGCAGAA GACTACACTG TGATCTTCAC TGCCGGGAGC 
ACGGCTGCTC TCAAACTGGT GGCAGAGGCC TTTCCATGGG TGTCCCAGGG CCCAGAGAGC 
AGTGGGAGTC GCTTCTGTTA CCTCACCGAC AGCCACACCT CCGTAGTGGG TATGCGGAAC 
GTGACCATGG CTATAAATGT CATATCCACC CCGGTCAGGC CAGAGGACCT GTGGTCTGCA 
GAGGAACGTA GTGCTTCAGC CAGCAACCCA GACTGCCAGC TGCCGCATCT CTTCTGCTAC 
CCAGCTCAGA GTAACTTTTC TGGAGTCAGA TACCCCCTGT CCTGGATAGA AGAGGTCAAG 
TCTGGGCGGT TGCACCCTGT GAGCACGCCT GGGAAGTGGT TTGTGCTGCT GGATGCAGCC 
TCCTACGTGA GCACCTCGCC TTTGGACCTG TCAGCTCACC AGGCCGACTT TGTCCCCATC 
TCCTTCTATA AGATCTTCGG GTTTCCTACA GGCCTGGGCG CTCTGCTGGT CCATAATCGT 
GCGGCTCCTC TACTGAGGAA GACCTACTTT GGAGGAGGGA CAGCCTCTGC GTACCTAGCA 
GGAGAAGACT TCTACATCCC GAGGCAGTCG GTAGCTCAGA GGTTTGAAGA TGGCACCATC 
TCATTCCTTG ATGTTATCGC GCTAAAACAT GGATTTGACA CCCTAGAGCG CCTCACAGGT 
GGAATGGAGA ATATAAAGCA GCACACCTTC ACCTTGGCTC AGTATACCTA CGTGGCCCTG 
TCCTCTCTCC AGTACCCCAA TGGAGCCCCT GTGGTGCGGA TTTACAGCGA TTCTGAGTTC 
AGCAGCCCTG AGGTTCAGGG CCCAATCATC AATTTTAATG TGCTGGATGA CAAAGGGAAC 
ATCATTGGTT ACTCCCAGGT GGACAAAATG GCCAGTCTTT ACAACATCCA CCTGCGAACT 
GGCTGCTTCT GTAACACTGG GGCCTGCCAG AGGCACCTGG GCATAAGCAA CGAGATGGTC 
AGGAAGCATT TTCAGGCTGG TCATGTCTGT GGGGACAATA TGGACCTCAT AGATGGGCAG 
CCCACAGGAT CTGTGAGGAT TTCATTTGGA TACATGTCGA CGCTGGATGA TGTCCAGGCC 
TTTCTTAGGT TCATCATAGA CACTCGCCTG CACTCATCAG GGGACTGGCC TGTCCCTCAG 
GCCCATGCTG ACACCGGGGA GACTGGAGCC CCATCAGCAG ACAGCCAGGC TGATGTTATA 
CCTGCTGTCA TGGGCAGACG TAGCCTCTCG CCTCAGGAAG ATGCCCTCAC AGGCTCCAGG 
GTTTGGAACA ACTCGTCTAC TGTGAATGCT GTGCCTGTGG CCCCACCTGT GTGTGATGTC 
GCCAGAACCC AGCCGACTCC TTCAGAGAAA GCTGCAGGAG TCCTGGAGGG GGCCCTTGGG 
CCACATGTTG TCACTAACCT TTATCTCTAT CCAATCAAAT CCTGTGCTGC ATTTGAGGTG 
ACCAGGTGGC CTGTAGGAAA CCAAGGGCTG CTATATGACC GGAGCTGGAT GGTTGTGAAT 
CACAATGGTG TTTGCCTGAG TCAGAAGCAG GAACCCCGGC TCTGCCTGAT CCAGCCCTTC 
ATCGACTTGC GGCAAAGGAT CATGGTCATC AAAGCCAAAG GGATGGAGCC TATAGAGGTG 
CCTCTTGAGG AAAATAGTGA ACGGACTCAG ATTCGCCAAA GCAGGGTCTG TGCTGACAGA 
GTAAGTACTT ATGATTGTGG AGAAAAAATT TCAAGCTGGT TGTCAACATT TTTTGGCCGT 
CCTTGTCATT TGATCAAACA AAGTTCAAAC TCTCAAAGGA ATGCAAAGAA GAAACATGGA 
AAAGATCAAC TTCCTGGTAC AATGGCCACC CTTTCTCTGG TGAATGAGGC ACAGTATCTG 
CTGATCAACA CATCCAGTAT TTTGGAACTT CACCGGCAAC TAAACACCAG TGATGAGAAT 
GGAAAGGAGG AATTATTCTC ACTGAAGGAT CTCAGCTTGC GTTTTCGTGC CAATATTATT 
ATCAATGGAA AAAGGGCTTT TGAAGAAGAG AAATGGGATG AGATTTCAAT TGGCTCTTTG 
CGTTTCCAGG TTTTGGGGCC TTGTCACAGA TGCCAGATGA TTTGCATCGA CCAGCAAACT 
GGGCAACGAA ACCAGCATGT TTTCCAAAAA CTTTCTGAGA GTCGTGAAAC AAAGGTGAAC 
TTTGGCATGT ACCTGATGCA TGCATCATTG GATTTATCCT CCCCATGTTT CCTGTCTGTA 
GGATCTCAGG TGCTCCCTGT GTTGAAAGAG AATGTGGAAG GTCATGATTT ACCTGCATCT 
GAGAAACACC AGGATGTTAC CTCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

NP_060417.2

Translation

MAGAAAESGRELWTFAGSRDPSAPRLAYGYGPGSLRELRAREFSRLAGTVYLDHAGATLFSQSQLESFTSDLMENTYGNPHSQNISSKLTHDTVEQVRYRILAHFHTTAEDYTVIFTAGSTAALKLVAEAFPWVSQGPESSGSRFCYLTDSHTSVVGMRNVTMAINVISTPVRPEDLWSAEERSASASNPDCQLPHLFCYPAQSNFSGVRYPLSWIEEVKSGRLHPVSTPGKWFVLLDAASYVSTSPLDLSAHQADFVPISFYKIFGFPTGLGALLVHNRAAPLLRKTYFGGGTASAYLAGEDFYIPRQSVAQRFEDGTISFLDVIALKHGFDTLERLTGGMENIKQHTFTLAQYTYVALSSLQYPNGAPVVRIYSDSEFSSPEVQGPIINFNVLDDKGNIIGYSQVDKMASLYNIHLRTGCFCNTGACQRHLGISNEMVRKHFQAGHVCGDNMDLIDGQPTGSVRISFGYMSTLDDVQAFLRFIIDTRLHSSGDWPVPQAHADTGETGAPSADSQADVIPAVMGRRSLSPQEDALTGSRVWNNSSTVNAVPVAPPVCDVARTQPTPSEKAAGVLEGALGPHVVTNLYLYPIKSCAAFEVTRWPVGNQGLLYDRSWMVVNHNGVCLSQKQEPRLCLIQPFIDLRQRIMVIKAKGMEPIEVPLEENSERTQIRQSRVCADRVSTYDCGEKISSWLSTFFGRPCHLIKQSSNSQRNAKKKHGKDQLPGTMATLSLVNEAQYLLINTSSILELHRQLNTSDENGKEELFSLKDLSLRFRANIIINGKRAFEEEKWDEISIGSLRFQVLGPCHRCQMICIDQQTGQRNQHVFQKLSESRETKVNFGMYLMHASLDLSSPCFLSVGSQVLPVLKENVEGHDLPASEKHQDVTS

Target ORF information:

RefSeq Version	NM_017947.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens molybdenum cofactor sulfurase (MOCOS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017947.2

ORF Insert Sequence:

ATGGCCGGCG CGGCGGCGGA GTCAGGGCGG GAGCTGTGGA CCTTCGCGGG TTCCCGGGAC 
CCGAGCGCAC CGCGGCTAGC CTACGGCTAC GGCCCGGGCA GCCTGCGCGA GCTGCGGGCG 
CGCGAGTTCA GCCGCCTGGC AGGAACTGTC TATCTTGACC ATGCAGGTGC CACCTTGTTC 
TCCCAGAGCC AGCTCGAAAG CTTCACTAGT GATCTCATGG AAAACACTTA TGGTAATCCT 
CACAGCCAGA ACATCAGCAG CAAGCTCACC CATGACACTG TGGAGCAGGT GCGCTACAGA 
ATCCTGGCGC ACTTCCACAC CACCGCAGAA GACTACACTG TGATCTTCAC TGCCGGGAGC 
ACGGCTGCTC TCAAACTGGT GGCAGAGGCC TTTCCATGGG TGTCCCAGGG CCCAGAGAGC 
AGTGGGAGTC GCTTCTGTTA CCTCACCGAC AGCCACACCT CCGTAGTGGG TATGCGGAAC 
GTGACCATGG CTATAAATGT CATATCCACC CCGGTCAGGC CAGAGGACCT GTGGTCTGCA 
GAGGAACGTA GTGCTTCAGC CAGCAACCCA GACTGCCAGC TGCCGCATCT CTTCTGCTAC 
CCAGCTCAGA GTAACTTTTC TGGAGTCAGA TACCCCCTGT CCTGGATAGA AGAGGTCAAG 
TCTGGGCGGT TGCACCCTGT GAGCACGCCT GGGAAGTGGT TTGTGCTGCT GGATGCAGCC 
TCCTACGTGA GCACCTCGCC TTTGGACCTG TCAGCTCACC AGGCCGACTT TGTCCCCATC 
TCCTTCTATA AGATCTTCGG GTTTCCTACA GGCCTGGGCG CTCTGCTGGT CCATAATCGT 
GCGGCTCCTC TACTGAGGAA GACCTACTTT GGAGGAGGGA CAGCCTCTGC GTACCTAGCA 
GGAGAAGACT TCTACATCCC GAGGCAGTCG GTAGCTCAGA GGTTTGAAGA TGGCACCATC 
TCATTCCTTG ATGTTATCGC GCTAAAACAT GGATTTGACA CCCTAGAGCG CCTCACAGGT 
GGAATGGAGA ATATAAAGCA GCACACCTTC ACCTTGGCTC AGTATACCTA CGTGGCCCTG 
TCCTCTCTCC AGTACCCCAA TGGAGCCCCT GTGGTGCGGA TTTACAGCGA TTCTGAGTTC 
AGCAGCCCTG AGGTTCAGGG CCCAATCATC AATTTTAATG TGCTGGATGA CAAAGGGAAC 
ATCATTGGTT ACTCCCAGGT GGACAAAATG GCCAGTCTTT ACAACATCCA CCTGCGAACT 
GGCTGCTTCT GTAACACTGG GGCCTGCCAG AGGCACCTGG GCATAAGCAA CGAGATGGTC 
AGGAAGCATT TTCAGGCTGG TCATGTCTGT GGGGACAATA TGGACCTCAT AGATGGGCAG 
CCCACAGGAT CTGTGAGGAT TTCATTTGGA TACATGTCGA CGCTGGATGA TGTCCAGGCC 
TTTCTTAGGT TCATCATAGA CACTCGCCTG CACTCATCAG GGGACTGGCC TGTCCCTCAG 
GCCCATGCTG ACACCGGGGA GACTGGAGCC CCATCAGCAG ACAGCCAGGC TGATGTTATA 
CCTGCTGTCA TGGGCAGACG TAGCCTCTCG CCTCAGGAAG ATGCCCTCAC AGGCTCCAGG 
GTTTGGAACA ACTCGTCTAC TGTGAATGCT GTGCCTGTGG CCCCACCTGT GTGTGATGTC 
GCCAGAACCC AGCCGACTCC TTCAGAGAAA GCTGCAGGAG TCCTGGAGGG GGCCCTTGGG 
CCACATGTTG TCACTAACCT TTATCTCTAT CCAATCAAAT CCTGTGCTGC ATTTGAGGTG 
ACCAGGTGGC CTGTAGGAAA CCAAGGGCTG CTATATGACC GGAGCTGGAT GGTTGTGAAT 
CACAATGGTG TTTGCCTGAG TCAGAAGCAG GAACCCCGGC TCTGCCTGAT CCAGCCCTTC 
ATCGACTTGC GGCAAAGGAT CATGGTCATC AAAGCCAAAG GGATGGAGCC TATAGAGGTG 
CCTCTTGAGG AAAATAGTGA ACGGACTCAG ATTCGCCAAA GCAGGGTCTG TGCTGACAGA 
GTAAGTACTT ATGATTGTGG AGAAAAAATT TCAAGCTGGT TGTCAACATT TTTTGGCCGT 
CCTTGTCATT TGATCAAACA AAGTTCAAAC TCTCAAAGGA ATGCAAAGAA GAAACATGGA 
AAAGATCAAC TTCCTGGTAC AATGGCCACC CTTTCTCTGG TGAATGAGGC ACAGTATCTG 
CTGATCAACA CATCCAGTAT TTTGGAACTT CACCGGCAAC TAAACACCAG TGATGAGAAT 
GGAAAGGAGG AATTATTCTC ACTGAAGGAT CTCAGCTTGC GTTTTCGTGC CAATATTATT 
ATCAATGGAA AAAGGGCTTT TGAAGAAGAG AAATGGGATG AGATTTCAAT TGGCTCTTTG 
CGTTTCCAGG TTTTGGGGCC TTGTCACAGA TGCCAGATGA TTTGCATCGA CCAGCAAACT 
GGGCAACGAA ACCAGCATGT TTTCCAAAAA CTTTCTGAGA GTCGTGAAAC AAAGGTGAAC 
TTTGGCATGT ACCTGATGCA TGCATCATTG GATTTATCCT CCCCATGTTT CCTGTCTGTA 
GGATCTCAGG TGCTCCCTGT GTTGAAAGAG AATGTGGAAG GTCATGATTT ACCTGCATCT 
GAGAAACACC AGGATGTTAC CTCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MOCOS ( NM_017947.3 ) cDNA ORF clone, Homo sapiens(Human) -> NP_060417.3 Homo sapiens molybdenum cofactor sulfurase (MOCOS), mRNA.

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CloneID	OHu102433
Clone ID Related Accession (Same CDS sequence)	NM_017947.3
Accession Version	NM_017947.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2667bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-09
Organism	Homo sapiens(human)
Product	molybdenum cofactor sulfurase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC023043.8, BC012079.1 and AK222886.1. This sequence is a reference standard in the RefSeqGene project. On Apr 20, 2017 this sequence version replaced NM_017947.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK222886.1, BC012079.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGGCG CGGCGGCGGA GTCAGGGCGG GAGCTGTGGA CCTTCGCGGG TTCCCGGGAC 
CCGAGCGCAC CGCGGCTAGC CTACGGCTAC GGCCCGGGCA GCCTGCGCGA GCTGCGGGCG 
CGCGAGTTCA GCCGCCTGGC AGGAACTGTC TATCTTGACC ATGCAGGTGC CACCTTGTTC 
TCCCAGAGCC AGCTCGAAAG CTTCACTAGT GATCTCATGG AAAACACTTA TGGTAATCCT 
CACAGCCAGA ACATCAGCAG CAAGCTCACC CATGACACTG TGGAGCAGGT GCGCTACAGA 
ATCCTGGCGC ACTTCCACAC CACCGCAGAA GACTACACTG TGATCTTCAC TGCCGGGAGC 
ACGGCTGCTC TCAAACTGGT GGCAGAGGCC TTTCCATGGG TGTCCCAGGG CCCAGAGAGC 
AGTGGGAGTC GCTTCTGTTA CCTCACCGAC AGCCACACCT CCGTAGTGGG TATGAGGAAC 
GTGACCATGG CTATAAATGT CATATCCATC CCGGTCAGGC CAGAGGACCT GTGGTCTGCA 
GAGGAACGTG GTGCTTCAGC CAGCAACCCA GACTGCCAGC TGCCGCATCT CTTCTGCTAC 
CCAGCTCAGA GTAACTTTTC TGGAGTCAGA TACCCCCTGT CCTGGATAGA AGAGGTCAAG 
TCTGGGCGGT TGCGCCCTGT GAGCACGCCT GGGAAGTGGT TTGTGCTGCT GGATGCAGCC 
TCCTACGTGA GCACCTCGCC TTTGGACCTG TCAGCTCACC AGGCCGACTT TGTCCCCATC 
TCCTTCTATA AGATCTTCGG GTTTCCTACA GGCCTGGGCG CTCTGCTGGT CCATAATCGT 
GCGGCTCCTC TACTGAGGAA GACCTACTTT GGAGGAGGGA CAGCCTCTGC GTACCTAGCA 
GGAGAAGACT TCTACATCCC GAGGCAGTCG GTAGCTCAGA GGTTTGAAGA TGGCACCATC 
TCATTCCTTG ATGTTATCGC GCTAAAACAT GGATTTGACA CCCTAGAGCG CCTCACAGGT 
GGAATGGAGA ATATAAAGCA GCACACCTTC ACCTTGGCTC AGTATACCTA CATGGCCCTG 
TCCTCTCTCC AGTACCCCAA TGGAGCCCCT GTGGTGCGGA TTTACAGCGA TTCTGAGTTC 
AGCAGCCCTG AGGTTCAGGG CCCGATCATC AATTTTAATG TGCTGGATGA CAAAGGGAAC 
ATCATTGGTT ACTCCCAGGT GGACAAAATG GCCAGTCTTT ACAACATCCA CCTGCGAACT 
GGCTGCTTCT GTAACACTGG GGCCTGCCAG AGGCACCTGG GCATAAGCAA CGAGATGGTC 
AGGAAGCATT TTCAGGCTGG TCATGTCTGT GGGGACAATA TGGACCTCAT AGATGGGCAG 
CCCACAGGAT CTGTGAGGAT TTCATTTGGA TACATGTCGA CGCTGGATGA TGTCCAGGCC 
TTTCTTAGGT TCATCATAGA CACTCGCCTG CACTCATCAG GGGACTGGCC TGTCCCTCAG 
GCCCATGCTG ACACCGGGGA GACTGGAGCC CCATCAGCAG ACAGCCAGGC TGATGTTATA 
CCTGCTGTCA TGGGCAGACG TAGCCTCTCG CCTCAGGAAG ATGCCCTCAC AGGCTCCAGG 
GTTTGGAACA ACTCGTCTAC TGTGAATGCT GTGCCTGTGG CCCCACCTGT GTGTGATGTC 
GCCAGAACCC AGCCGACTCC TTCAGAGAAA GCTGCAGGAG TCCTGGAGGG GGCCCTTGGG 
CCACATGTTG TCACTAACCT TTATCTCTAT CCAATCAAAT CCTGTGCTGC ATTTGAGGTG 
ACCAGGTGGC CTGTAGGAAA CCAAGGGCTG CTATATGACC GGAGCTGGAT GGTTGTGAAT 
CACAATGGTG TTTGCCTGAG TCAGAAGCAG GAACCCCGGC TCTGCCTGAT CCAGCCCTTC 
ATCGACTTGC GGCAAAGGAT CATGGTCATC AAAGCCAAAG GGATGGAGCC TATAGAGGTG 
CCTCTTGAGG AAAATAGTGA ACGGACTCAG ATTCGCCAAA GCAGGGTCTG TGCTGACAGA 
GTAAGTACTT ATGATTGTGG AGAAAAAATT TCAAGCTGGT TGTCAACATT TTTTGGCCGT 
CCTTGTCATT TGATCAAACA AAGTTCAAAC TCTCAAAGGA ATGCAAAGAA GAAACATGGA 
AAAGATCAAC TTCCTGGTAC AATGGCCACC CTTTCTCTGG TGAATGAGGC ACAGTATCTG 
CTGATCAACA CATCCAGTAT TTTGGAACTT CACCGGCAAC TAAACACCAG TGATGAGAAT 
GGAAAGGAGG AATTATTCTC ACTGAAGGAT CTCAGCTTGC GTTTTCGTGC CAATATTATT 
ATCAATGGAA AAAGGGCTTT TGAAGAAGAG AAATGGGATG AGATTTCAAT TGGCTCTTTG 
CGTTTCCAGG TTTTGGGGCC TTGTCACAGA TGCCAGATGA TTTGCATCGA CCAGCAAACT 
GGGCAACGAA ACCAGCATGT TTTCCAAAAA CTTTCTGAGA GTCGTGAAAC AAAGGTGAAC 
TTTGGCATGT ACCTGATGCA TGCATCATTG GATTTATCCT CCCCATGTTT CCTGTCTGTA 
GGATCTCAGG TGCTCCCTGT GTTGAAAGAG AATGTGGAAG GTCATGATTT ACCTGCATCT 
GAGAAACACC AGGATGTTAC CTCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060417.3
CDS	331..2997
Translation	MAGAAAESGRELWTFAGSRDPSAPRLAYGYGPGSLRELRAREFSRLAGTVYLDHAGATLFSQSQLESFTSDLMENTYGNPHSQNISSKLTHDTVEQVRYRILAHFHTTAEDYTVIFTAGSTAALKLVAEAFPWVSQGPESSGSRFCYLTDSHTSVVGMRNVTMAINVISIPVRPEDLWSAEERGASASNPDCQLPHLFCYPAQSNFSGVRYPLSWIEEVKSGRLRPVSTPGKWFVLLDAASYVSTSPLDLSAHQADFVPISFYKIFGFPTGLGALLVHNRAAPLLRKTYFGGGTASAYLAGEDFYIPRQSVAQRFEDGTISFLDVIALKHGFDTLERLTGGMENIKQHTFTLAQYTYMALSSLQYPNGAPVVRIYSDSEFSSPEVQGPIINFNVLDDKGNIIGYSQVDKMASLYNIHLRTGCFCNTGACQRHLGISNEMVRKHFQAGHVCGDNMDLIDGQPTGSVRISFGYMSTLDDVQAFLRFIIDTRLHSSGDWPVPQAHADTGETGAPSADSQADVIPAVMGRRSLSPQEDALTGSRVWNNSSTVNAVPVAPPVCDVARTQPTPSEKAAGVLEGALGPHVVTNLYLYPIKSCAAFEVTRWPVGNQGLLYDRSWMVVNHNGVCLSQKQEPRLCLIQPFIDLRQRIMVIKAKGMEPIEVPLEENSERTQIRQSRVCADRVSTYDCGEKISSWLSTFFGRPCHLIKQSSNSQRNAKKKHGKDQLPGTMATLSLVNEAQYLLINTSSILELHRQLNTSDENGKEELFSLKDLSLRFRANIIINGKRAFEEEKWDEISIGSLRFQVLGPCHRCQMICIDQQTGQRNQHVFQKLSESRETKVNFGMYLMHASLDLSSPCFLSVGSQVLPVLKENVEGHDLPASEKHQDVTS

Target ORF information:

RefSeq Version	NM_017947.3
Organism	Homo sapiens(human)
Definition	Homo sapiens molybdenum cofactor sulfurase (MOCOS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017947.3

ORF Insert Sequence:

ATGGCCGGCG CGGCGGCGGA GTCAGGGCGG GAGCTGTGGA CCTTCGCGGG TTCCCGGGAC 
CCGAGCGCAC CGCGGCTAGC CTACGGCTAC GGCCCGGGCA GCCTGCGCGA GCTGCGGGCG 
CGCGAGTTCA GCCGCCTGGC AGGAACTGTC TATCTTGACC ATGCAGGTGC CACCTTGTTC 
TCCCAGAGCC AGCTCGAAAG CTTCACTAGT GATCTCATGG AAAACACTTA TGGTAATCCT 
CACAGCCAGA ACATCAGCAG CAAGCTCACC CATGACACTG TGGAGCAGGT GCGCTACAGA 
ATCCTGGCGC ACTTCCACAC CACCGCAGAA GACTACACTG TGATCTTCAC TGCCGGGAGC 
ACGGCTGCTC TCAAACTGGT GGCAGAGGCC TTTCCATGGG TGTCCCAGGG CCCAGAGAGC 
AGTGGGAGTC GCTTCTGTTA CCTCACCGAC AGCCACACCT CCGTAGTGGG TATGAGGAAC 
GTGACCATGG CTATAAATGT CATATCCATC CCGGTCAGGC CAGAGGACCT GTGGTCTGCA 
GAGGAACGTG GTGCTTCAGC CAGCAACCCA GACTGCCAGC TGCCGCATCT CTTCTGCTAC 
CCAGCTCAGA GTAACTTTTC TGGAGTCAGA TACCCCCTGT CCTGGATAGA AGAGGTCAAG 
TCTGGGCGGT TGCGCCCTGT GAGCACGCCT GGGAAGTGGT TTGTGCTGCT GGATGCAGCC 
TCCTACGTGA GCACCTCGCC TTTGGACCTG TCAGCTCACC AGGCCGACTT TGTCCCCATC 
TCCTTCTATA AGATCTTCGG GTTTCCTACA GGCCTGGGCG CTCTGCTGGT CCATAATCGT 
GCGGCTCCTC TACTGAGGAA GACCTACTTT GGAGGAGGGA CAGCCTCTGC GTACCTAGCA 
GGAGAAGACT TCTACATCCC GAGGCAGTCG GTAGCTCAGA GGTTTGAAGA TGGCACCATC 
TCATTCCTTG ATGTTATCGC GCTAAAACAT GGATTTGACA CCCTAGAGCG CCTCACAGGT 
GGAATGGAGA ATATAAAGCA GCACACCTTC ACCTTGGCTC AGTATACCTA CATGGCCCTG 
TCCTCTCTCC AGTACCCCAA TGGAGCCCCT GTGGTGCGGA TTTACAGCGA TTCTGAGTTC 
AGCAGCCCTG AGGTTCAGGG CCCGATCATC AATTTTAATG TGCTGGATGA CAAAGGGAAC 
ATCATTGGTT ACTCCCAGGT GGACAAAATG GCCAGTCTTT ACAACATCCA CCTGCGAACT 
GGCTGCTTCT GTAACACTGG GGCCTGCCAG AGGCACCTGG GCATAAGCAA CGAGATGGTC 
AGGAAGCATT TTCAGGCTGG TCATGTCTGT GGGGACAATA TGGACCTCAT AGATGGGCAG 
CCCACAGGAT CTGTGAGGAT TTCATTTGGA TACATGTCGA CGCTGGATGA TGTCCAGGCC 
TTTCTTAGGT TCATCATAGA CACTCGCCTG CACTCATCAG GGGACTGGCC TGTCCCTCAG 
GCCCATGCTG ACACCGGGGA GACTGGAGCC CCATCAGCAG ACAGCCAGGC TGATGTTATA 
CCTGCTGTCA TGGGCAGACG TAGCCTCTCG CCTCAGGAAG ATGCCCTCAC AGGCTCCAGG 
GTTTGGAACA ACTCGTCTAC TGTGAATGCT GTGCCTGTGG CCCCACCTGT GTGTGATGTC 
GCCAGAACCC AGCCGACTCC TTCAGAGAAA GCTGCAGGAG TCCTGGAGGG GGCCCTTGGG 
CCACATGTTG TCACTAACCT TTATCTCTAT CCAATCAAAT CCTGTGCTGC ATTTGAGGTG 
ACCAGGTGGC CTGTAGGAAA CCAAGGGCTG CTATATGACC GGAGCTGGAT GGTTGTGAAT 
CACAATGGTG TTTGCCTGAG TCAGAAGCAG GAACCCCGGC TCTGCCTGAT CCAGCCCTTC 
ATCGACTTGC GGCAAAGGAT CATGGTCATC AAAGCCAAAG GGATGGAGCC TATAGAGGTG 
CCTCTTGAGG AAAATAGTGA ACGGACTCAG ATTCGCCAAA GCAGGGTCTG TGCTGACAGA 
GTAAGTACTT ATGATTGTGG AGAAAAAATT TCAAGCTGGT TGTCAACATT TTTTGGCCGT 
CCTTGTCATT TGATCAAACA AAGTTCAAAC TCTCAAAGGA ATGCAAAGAA GAAACATGGA 
AAAGATCAAC TTCCTGGTAC AATGGCCACC CTTTCTCTGG TGAATGAGGC ACAGTATCTG 
CTGATCAACA CATCCAGTAT TTTGGAACTT CACCGGCAAC TAAACACCAG TGATGAGAAT 
GGAAAGGAGG AATTATTCTC ACTGAAGGAT CTCAGCTTGC GTTTTCGTGC CAATATTATT 
ATCAATGGAA AAAGGGCTTT TGAAGAAGAG AAATGGGATG AGATTTCAAT TGGCTCTTTG 
CGTTTCCAGG TTTTGGGGCC TTGTCACAGA TGCCAGATGA TTTGCATCGA CCAGCAAACT 
GGGCAACGAA ACCAGCATGT TTTCCAAAAA CTTTCTGAGA GTCGTGAAAC AAAGGTGAAC 
TTTGGCATGT ACCTGATGCA TGCATCATTG GATTTATCCT CCCCATGTTT CCTGTCTGTA 
GGATCTCAGG TGCTCCCTGT GTTGAAAGAG AATGTGGAAG GTCATGATTT ACCTGCATCT 
GAGAAACACC AGGATGTTAC CTCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Polymorphism of genes involved in purine metabolism (XDH, AOX1, MOCOS) in kidney transplant recipients receiving azathioprine.
Therapeutic drug monitoring34(3)266-74(2012 Jun)
Kurzawski M,Dziewanowski K,Safranow K,Drozdzik M

Next-generation sequencing to generate interactome datasets.
Nature methods8(6)478-80(2011 Jun)
Yu H,Tardivo L,Tam S,Weiner E,Gebreab F,Fan C,Svrzikapa N,Hirozane-Kishikawa T,Rietman E,Yang X,Sahalie J,Salehi-Ashtiani K,Hao T,Cusick ME,Hill DE,Roth FP,Braun P,Vidal M

Novel pharmacogenetic markers for treatment outcome in azathioprine-treated inflammatory bowel disease.
Alimentary pharmacology & therapeutics30(4)375-84(2009 Aug)
Smith MA,Marinaki AM,Arenas M,Shobowale-Bakre M,Lewis CM,Ansari A,Duley J,Sanderson JD

Identification and characterization of the first mutation (Arg776Cys) in the C-terminal domain of the Human Molybdenum Cofactor Sulfurase (HMCS) associated with type II classical xanthinuria.
Molecular genetics and metabolism91(1)23-9(2007 May)
Peretz H,Naamati MS,Levartovsky D,Lagziel A,Shani E,Horn I,Shalev H,Landau D

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MOCOS cDNA ORF clone, Homo sapiens(Human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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