PPP1R1A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PPP1R1A
Entrez Gene ID	5502
Full Name	protein phosphatase 1 regulatory inhibitor subunit 1A
Synonyms	I1,IPP1
General protein information	Preferred Names protein phosphatase 1 regulatory inhibitor subunit 1A Names protein phosphatase 1 regulatory subunit 1A I-1 IPP-1 inhibitor-1 protein phosphatase inhibitor-1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q13.2
Disorder MIM:	613246

mRNA and Protein(s)

mRNA	Protein	Name
NM_006741.3	NP_006732.3	protein phosphatase 1 regulatory subunit 1A
XM_006719471.4	XP_006719534.1	protein phosphatase 1 regulatory subunit 1A isoform X1
XM_006719471.3	XP_006719534.1	protein phosphatase 1 regulatory subunit 1A isoform X1
NM_006741.4	NP_006732.3	protein phosphatase 1 regulatory subunit 1A
XM_005268995.4	XP_005269052.1	protein phosphatase 1 regulatory subunit 1A isoform X2

Pathways from BioSystems

Homologies

	PPP1R1A	XP_001110247.1
Pan troglodytes (chimpanzee)	PPP1R1A	XP_001156163.2
Homo sapiens (human)	PPP1R1A	NP_006732.3
Mus musculus (house mouse)	Ppp1r1a	NP_067366.1
Rattus norvegicus (Norway rat)	Ppp1r1a	NP_073167.1

Gene Ontology
Bibliography

Related articles in PubMed

Protein phosphatase 1 regulatory subunit 1A in ewing sarcoma tumorigenesis and metastasis.
Luo W, Xu C, Ayello J, Dela Cruz F, Rosenblum JM, Lessnick SL, Cairo MS
Oncogene(2017 Oct)

Human G109E-inhibitor-1 impairs cardiac function and promotes arrhythmias.
Haghighi K, Pritchard TJ, Liu GS, Singh VP, Bidwell P, Lam CK, Vafiadaki E, Das P, Ma J, Kunduri S, Sanoudou D, Florea S, Vanderbilt E, Wang HS, Rubinstein J, Hajjar RJ, Kranias EG
Journal of molecular and cellular cardiology89(Pt B)349-59(2015 Dec)

Synergistic role of protein phosphatase inhibitor 1 and sarco/endoplasmic reticulum Ca2+ -ATPase in the acquisition of the contractile phenotype of arterial smooth muscle cells.
Lipskaia L, Bobe R, Chen J, Turnbull IC, Lopez JJ, Merlet E, Jeong D, Karakikes I, Ross AS, Liang L, Mougenot N, Atassi F, Lompr? AM, Tarzami ST, Kovacic JC, Kranias E, Hajjar RJ, Hadri L
Circulation129(7)773-85(2014 Feb)

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S,
Diabetes care33(10)2250-3(2010 Oct)

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, , ,
American journal of human genetics85(5)628-42(2009 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These findings suggest that the human G109E inhibitor-1 variant impairs sarcoplasmic reticulum Ca-cycling and promotes arrhythmogenesis under stress conditions.
Title: Human G109E-inhibitor-1 impairs cardiac function and promotes arrhythmias.

I-1 and sarco/endoplasmic reticulum Ca2+ -ATPase synergistically induce the vascular smooth muscle cell contractile phenotype.
Title: Synergistic role of protein phosphatase inhibitor 1 and sarco/endoplasmic reticulum Ca2+ -ATPase in the acquisition of the contractile phenotype of arterial smooth muscle cells.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: The human G147D-protein phosphatase 1 inhibitor-1 polymorphism is not associated with altered clinical characteristics in heart failure.

The following PPP1R1A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PPP1R1A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17444	NM_006741.4 Latest version!	Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1A (PPP1R1A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu46653	XM_006719471.4 Latest version!	Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1A (PPP1R1A), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu46654	XM_005268995.4 Latest version!	Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1A (PPP1R1A), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu46653	XM_006719471.3	Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1A (PPP1R1A), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu17444	NM_006741.3	Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1A (PPP1R1A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PPP1R1A ( NM_006741.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006732.3 Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1A (PPP1R1A), mRNA.

Price & Availability↑

CloneID	OHu17444
Clone ID Related Accession (Same CDS sequence)	NM_006741.3 , NM_006741.4
Accession Version	NM_006741.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 516bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	protein phosphatase 1 regulatory subunit 1A
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP211831.1, U48707.1, AC079310.20 and BM876308.1. On Aug 10, 2007 this sequence version replaced NM_006741.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC022470.1, SRR1660807.97540.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142680, SAMEA2154125 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCAAG ACAACAGCCC CCGAAAGATC CAGTTCACGG TCCCGCTGCT GGAGCCGCAC 
CTTGACCCCG AGGCGGCGGA GCAGATTCGG AGGCGCCGCC CCACCCCTGC CACCCTCGTG 
CTGACCAGTG ACCAGTCATC CCCAGAGATA GATGAAGACC GGATCCCCAA CCCACATCTC 
AAGTCCACTT TGGCAATGTC TCCACGGCAA CGGAAGAAGA TGACAAGGAT CACACCCACA 
ATGAAAGAGC TCCAGATGAT GGTTGAACAT CACCTGGGGC AACAGCAGCA AGGAGAGGAA 
CCTGAGGGGG CCGCTGAGAG CACAGGAACC CAGGAGTCCC GCCCACCTGG GATCCCAGAC 
ACAGAAGTGG AGTCAAGGCT GGGCACCTCT GGGACAGCAA AAAAAACTGC AGAATGCATC 
CCTAAAACTC ACGAGAGAGG CAGTAAGGAA CCCAGCACAA AAGAACCCTC AACCCATATA 
CCACCACTGG ATTCCAAGGG AGCCAACTCG GTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006732.3
CDS	172..687
Translation	MEQDNSPRKIQFTVPLLEPHLDPEAAEQIRRRRPTPATLVLTSDQSSPEIDEDRIPNPHLKSTLAMSPRQRKKMTRITPTMKELQMMVEHHLGQQQQGEEPEGAAESTGTQESRPPGIPDTEVESRLGTSGTAKKTAECIPKTHERGSKEPSTKEPSTHIPPLDSKGANSV

Target ORF information:

RefSeq Version	NM_006741.3
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1A (PPP1R1A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006741.3

ORF Insert Sequence:

ATGGAGCAAG ACAACAGCCC CCGAAAGATC CAGTTCACGG TCCCGCTGCT GGAGCCGCAC 
CTTGACCCCG AGGCGGCGGA GCAGATTCGG AGGCGCCGCC CCACCCCTGC CACCCTCGTG 
CTGACCAGTG ACCAGTCATC CCCAGAGATA GATGAAGACC GGATCCCCAA CCCACATCTC 
AAGTCCACTT TGGCAATGTC TCCACGGCAA CGGAAGAAGA TGACAAGGAT CACACCCACA 
ATGAAAGAGC TCCAGATGAT GGTTGAACAT CACCTGGGGC AACAGCAGCA AGGAGAGGAA 
CCTGAGGGGG CCGCTGAGAG CACAGGAACC CAGGAGTCCC GCCCACCTGG GATCCCAGAC 
ACAGAAGTGG AGTCAAGGCT GGGCACCTCT GGGACAGCAA AAAAAACTGC AGAATGCATC 
CCTAAAACTC ACGAGAGAGG CAGTAAGGAA CCCAGCACAA AAGAACCCTC AACCCATATA 
CCACCACTGG ATTCCAAGGG AGCCAACTCG GTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PPP1R1A ( NM_006741.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006732.3 Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1A (PPP1R1A), mRNA.

Price & Availability↑

CloneID	OHu17444
Clone ID Related Accession (Same CDS sequence)	NM_006741.3 , NM_006741.4
Accession Version	NM_006741.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 516bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	protein phosphatase 1 regulatory subunit 1A
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP211831.1, U48707.1, AC079310.20 and BM876308.1. On Nov 24, 2018 this sequence version replaced NM_006741.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC022470.1, SRR1660807.97540.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142680, SAMEA2154125 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000257905.13/ ENSP00000257905.8 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGCAAG ACAACAGCCC CCGAAAGATC CAGTTCACGG TCCCGCTGCT GGAGCCGCAC 
CTTGACCCCG AGGCGGCGGA GCAGATTCGG AGGCGCCGCC CCACCCCTGC CACCCTCGTG 
CTGACCAGTG ACCAGTCATC CCCAGAGATA GATGAAGACC GGATCCCCAA CCCACATCTC 
AAGTCCACTT TGGCAATGTC TCCACGGCAA CGGAAGAAGA TGACAAGGAT CACACCCACA 
ATGAAAGAGC TCCAGATGAT GGTTGAACAT CACCTGGGGC AACAGCAGCA AGGAGAGGAA 
CCTGAGGGGG CCGCTGAGAG CACAGGAACC CAGGAGTCCC GCCCACCTGG GATCCCAGAC 
ACAGAAGTGG AGTCAAGGCT GGGCACCTCT GGGACAGCAA AAAAAACTGC AGAATGCATC 
CCTAAAACTC ACGAGAGAGG CAGTAAGGAA CCCAGCACAA AAGAACCCTC AACCCATATA 
CCACCACTGG ATTCCAAGGG AGCCAACTCG GTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006732.3
CDS	172..687
Translation	MEQDNSPRKIQFTVPLLEPHLDPEAAEQIRRRRPTPATLVLTSDQSSPEIDEDRIPNPHLKSTLAMSPRQRKKMTRITPTMKELQMMVEHHLGQQQQGEEPEGAAESTGTQESRPPGIPDTEVESRLGTSGTAKKTAECIPKTHERGSKEPSTKEPSTHIPPLDSKGANSV

Target ORF information:

RefSeq Version	NM_006741.4
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1A (PPP1R1A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006741.4

ORF Insert Sequence:

ATGGAGCAAG ACAACAGCCC CCGAAAGATC CAGTTCACGG TCCCGCTGCT GGAGCCGCAC 
CTTGACCCCG AGGCGGCGGA GCAGATTCGG AGGCGCCGCC CCACCCCTGC CACCCTCGTG 
CTGACCAGTG ACCAGTCATC CCCAGAGATA GATGAAGACC GGATCCCCAA CCCACATCTC 
AAGTCCACTT TGGCAATGTC TCCACGGCAA CGGAAGAAGA TGACAAGGAT CACACCCACA 
ATGAAAGAGC TCCAGATGAT GGTTGAACAT CACCTGGGGC AACAGCAGCA AGGAGAGGAA 
CCTGAGGGGG CCGCTGAGAG CACAGGAACC CAGGAGTCCC GCCCACCTGG GATCCCAGAC 
ACAGAAGTGG AGTCAAGGCT GGGCACCTCT GGGACAGCAA AAAAAACTGC AGAATGCATC 
CCTAAAACTC ACGAGAGAGG CAGTAAGGAA CCCAGCACAA AAGAACCCTC AACCCATATA 
CCACCACTGG ATTCCAAGGG AGCCAACTCG GTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PPP1R1A ( XM_006719471.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_006719534.1 Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1A (PPP1R1A), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu46653
Clone ID Related Accession (Same CDS sequence)	XM_006719471.4 , XM_006719471.3
Accession Version	XM_006719471.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 399bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	protein phosphatase 1 regulatory subunit 1A isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_006719471.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCAAG ACAACAGCCC CCGAAAGATC CAGTTCACGG TCCCGCTGCT GGAGCCGCAC 
CTTGACCCCG AGGCGGCGGA GCAGATTCGG AGGCGCCGCC CCACCCCTGC CACCCTCGTG 
CTGACCAGTG ACCAGTCATC CCCAGAGATA GATGAAGACC GGATCCCCAA CCCACATCTC 
AAGAAACTGC AGAATGCATC CCTAAAACTC ACGAGAGAGG CAGTAAGGAA CCCAGCACAA 
AAGAACCCTC AACCCATATA CCACCACTGG ATTCCAAGGG AGCCAACTCG GTCTGAGAGA 
GGAGGAGGTA TCTTGGGATC AAGACTGCAG TTTGGGAATG CATGGACACC GGATTTGTTT 
CTTATTCCTT CACTTTTGGG GAAAATCTCT TGTTTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006719534.1
CDS	155..553
Translation	MEQDNSPRKIQFTVPLLEPHLDPEAAEQIRRRRPTPATLVLTSDQSSPEIDEDRIPNPHLKKLQNASLKLTREAVRNPAQKNPQPIYHHWIPREPTRSERGGGILGSRLQFGNAWTPDLFLIPSLLGKISCF

Target ORF information:

RefSeq Version	XM_006719471.4
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1A (PPP1R1A), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006719471.4

ORF Insert Sequence:

ATGGAGCAAG ACAACAGCCC CCGAAAGATC CAGTTCACGG TCCCGCTGCT GGAGCCGCAC 
CTTGACCCCG AGGCGGCGGA GCAGATTCGG AGGCGCCGCC CCACCCCTGC CACCCTCGTG 
CTGACCAGTG ACCAGTCATC CCCAGAGATA GATGAAGACC GGATCCCCAA CCCACATCTC 
AAGAAACTGC AGAATGCATC CCTAAAACTC ACGAGAGAGG CAGTAAGGAA CCCAGCACAA 
AAGAACCCTC AACCCATATA CCACCACTGG ATTCCAAGGG AGCCAACTCG GTCTGAGAGA 
GGAGGAGGTA TCTTGGGATC AAGACTGCAG TTTGGGAATG CATGGACACC GGATTTGTTT 
CTTATTCCTT CACTTTTGGG GAAAATCTCT TGTTTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PPP1R1A ( XM_006719471.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_006719534.1 Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1A (PPP1R1A), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu46653
Clone ID Related Accession (Same CDS sequence)	XM_006719471.4 , XM_006719471.3
Accession Version	XM_006719471.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 399bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	protein phosphatase 1 regulatory subunit 1A isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006719471.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCAAG ACAACAGCCC CCGAAAGATC CAGTTCACGG TCCCGCTGCT GGAGCCGCAC 
CTTGACCCCG AGGCGGCGGA GCAGATTCGG AGGCGCCGCC CCACCCCTGC CACCCTCGTG 
CTGACCAGTG ACCAGTCATC CCCAGAGATA GATGAAGACC GGATCCCCAA CCCACATCTC 
AAGAAACTGC AGAATGCATC CCTAAAACTC ACGAGAGAGG CAGTAAGGAA CCCAGCACAA 
AAGAACCCTC AACCCATATA CCACCACTGG ATTCCAAGGG AGCCAACTCG GTCTGAGAGA 
GGAGGAGGTA TCTTGGGATC AAGACTGCAG TTTGGGAATG CATGGACACC GGATTTGTTT 
CTTATTCCTT CACTTTTGGG GAAAATCTCT TGTTTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006719534.1
CDS	166..564
Translation	MEQDNSPRKIQFTVPLLEPHLDPEAAEQIRRRRPTPATLVLTSDQSSPEIDEDRIPNPHLKKLQNASLKLTREAVRNPAQKNPQPIYHHWIPREPTRSERGGGILGSRLQFGNAWTPDLFLIPSLLGKISCF

Target ORF information:

RefSeq Version	XM_006719471.3
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1A (PPP1R1A), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006719471.3

ORF Insert Sequence:

ATGGAGCAAG ACAACAGCCC CCGAAAGATC CAGTTCACGG TCCCGCTGCT GGAGCCGCAC 
CTTGACCCCG AGGCGGCGGA GCAGATTCGG AGGCGCCGCC CCACCCCTGC CACCCTCGTG 
CTGACCAGTG ACCAGTCATC CCCAGAGATA GATGAAGACC GGATCCCCAA CCCACATCTC 
AAGAAACTGC AGAATGCATC CCTAAAACTC ACGAGAGAGG CAGTAAGGAA CCCAGCACAA 
AAGAACCCTC AACCCATATA CCACCACTGG ATTCCAAGGG AGCCAACTCG GTCTGAGAGA 
GGAGGAGGTA TCTTGGGATC AAGACTGCAG TTTGGGAATG CATGGACACC GGATTTGTTT 
CTTATTCCTT CACTTTTGGG GAAAATCTCT TGTTTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PPP1R1A ( XM_005268995.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_005269052.1 Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1A (PPP1R1A), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu46654
Clone ID Related Accession (Same CDS sequence)	XM_005268995.4
Accession Version	XM_005268995.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 360bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	protein phosphatase 1 regulatory subunit 1A isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005268995.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCAAG ACAACAGCCC CCGAAAGATC CAGTTCACGG TCCCGCTGCT GGAGCCGCAC 
CTTGACCCCG AGGCGGCGGA GCAGATTCGG AGGCGCCGCC CCACCCCTGC CACCCTCGTG 
CTGACCAGTG ACCAGTCATC CCCAGAGATA GATGAAGACC GGATCCCCAA CCCACATCTC 
AAGTCCACTT TGGCAATGTC TCCACGGCAA CGGAAGAAGA TGACAAGGAT CACACCCACA 
ATGAAAGAAA CTGCAGAATG CATCCCTAAA ACTCACGAGA GAGGCAGTAA GGAACCCAGC 
ACAAAAGAAC CCTCAACCCA TATACCACCA CTGGATTCCA AGGGAGCCAA CTCGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005269052.1
CDS	152..511
Translation	MEQDNSPRKIQFTVPLLEPHLDPEAAEQIRRRRPTPATLVLTSDQSSPEIDEDRIPNPHLKSTLAMSPRQRKKMTRITPTMKETAECIPKTHERGSKEPSTKEPSTHIPPLDSKGANSV

Target ORF information:

RefSeq Version	XM_005268995.4
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1A (PPP1R1A), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005268995.4

ORF Insert Sequence:

ATGGAGCAAG ACAACAGCCC CCGAAAGATC CAGTTCACGG TCCCGCTGCT GGAGCCGCAC 
CTTGACCCCG AGGCGGCGGA GCAGATTCGG AGGCGCCGCC CCACCCCTGC CACCCTCGTG 
CTGACCAGTG ACCAGTCATC CCCAGAGATA GATGAAGACC GGATCCCCAA CCCACATCTC 
AAGTCCACTT TGGCAATGTC TCCACGGCAA CGGAAGAAGA TGACAAGGAT CACACCCACA 
ATGAAAGAAA CTGCAGAATG CATCCCTAAA ACTCACGAGA GAGGCAGTAA GGAACCCAGC 
ACAAAAGAAC CCTCAACCCA TATACCACCA CTGGATTCCA AGGGAGCCAA CTCGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Protein phosphatase 1 regulatory subunit 1A in ewing sarcoma tumorigenesis and metastasis.
Oncogene(2017 Oct)
Luo W,Xu C,Ayello J,Dela Cruz F,Rosenblum JM,Lessnick SL,Cairo MS

Human G109E-inhibitor-1 impairs cardiac function and promotes arrhythmias.
Journal of molecular and cellular cardiology89(Pt B)349-59(2015 Dec)
Haghighi K,Pritchard TJ,Liu GS,Singh VP,Bidwell P,Lam CK,Vafiadaki E,Das P,Ma J,Kunduri S,Sanoudou D,Florea S,Vanderbilt E,Wang HS,Rubinstein J,Hajjar RJ,Kranias EG

Synergistic role of protein phosphatase inhibitor 1 and sarco/endoplasmic reticulum Ca2+ -ATPase in the acquisition of the contractile phenotype of arterial smooth muscle cells.
Circulation129(7)773-85(2014 Feb)
Lipskaia L,Bobe R,Chen J,Turnbull IC,Lopez JJ,Merlet E,Jeong D,Karakikes I,Ross AS,Liang L,Mougenot N,Atassi F,Lompr? AM,Tarzami ST,Kovacic JC,Kranias E,Hajjar RJ,Hadri L

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Diabetes care33(10)2250-3(2010 Oct)
Bailey SD,Xie C,Do R,Montpetit A,Diaz R,Mohan V,Keavney B,Yusuf S,Gerstein HC,Engert JC,Anand S,

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
American journal of human genetics85(5)628-42(2009 Nov)
Talmud PJ,Drenos F,Shah S,Shah T,Palmen J,Verzilli C,Gaunt TR,Pallas J,Lovering R,Li K,Casas JP,Sofat R,Kumari M,Rodriguez S,Johnson T,Newhouse SJ,Dominiczak A,Samani NJ,Caulfield M,Sever P,Stanton A,Shields DC,Padmanabhan S,Melander O,Hastie C,Delles C,Ebrahim S,Marmot MG,Smith GD,Lawlor DA,Munroe PB,Day IN,Kivimaki M,Whittaker J,Humphries SE,Hingorani AD,,,

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PPP1R1A cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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