LAMTOR1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LAMTOR1
Entrez Gene ID	55004
Full Name	late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
Synonyms	C11orf59,PDRO,Ragulator1,p18,p27RF-Rho
General protein information	Preferred Names late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 Names ragulator complex protein LAMTOR1 RhoA activator C11orf59 late endosomal/lysosomal adaptor and MAPK and MTOR activator 1 lipid raft adaptor protein p18 p27Kip1-releasing factor from RhoA p27kip1 releasing factor from RhoA protein associated with DRMs and endosomes ragulator complex protein PDRO
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q13.4
Disorder MIM:	613510

mRNA and Protein(s)

mRNA	Protein	Name
NM_017907.3	NP_060377.1	ragulator complex protein LAMTOR1
NM_017907.2	NP_060377.1	ragulator complex protein LAMTOR1

Pathways from BioSystems

Homologies

Homo sapiens (human)	LAMTOR1	NP_060377.1
Rattus norvegicus (Norway rat)	Lamtor1	NP_954533.1
Danio rerio (zebrafish)	lamtor1	XP_002667853.1
	C11orf59	XP_001114329.1
Bos taurus (cattle)	LAMTOR1	NP_001029941.1
Pan troglodytes (chimpanzee)	LAMTOR1	XP_508619.1
Canis lupus familiaris (dog)	LAMTOR1	XP_542329.2
Xenopus tropicalis (tropical clawed frog)	lamtor1	NP_989303.1
Gallus gallus (chicken)	LAMTOR1	XP_003643581.2
Mus musculus (house mouse)	Lamtor1	NP_079881.2
Rattus norvegicus (Norway rat)	LOC100361543	XP_002730282.1

Gene Ontology
Bibliography

Related articles in PubMed

LAMTOR/Ragulator is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning.
Filipek PA, de Araujo MEG, Vogel GF, De Smet CH, Eberharter D, Rebsamen M, Rudashevskaya EL, Kremser L, Yordanov T, Tschaikner P, F?rnrohr BG, Lechner S, Dunzendorfer-Matt T, Scheffzek K, Bennett KL, Superti-Furga G, Lindner HH, Stasyk T, Huber LA
The Journal of cell biology216(12)4199-4215(2017 Dec)

Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling.
de Araujo MEG, Naschberger A, F?rnrohr BG, Stasyk T, Dunzendorfer-Matt T, Lechner S, Welti S, Kremser L, Shivalingaiah G, Offterdinger M, Lindner HH, Huber LA, Scheffzek K
Science (New York, N.Y.)358(6361)377-381(2017 10)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

LAMTOR1 is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning.
Title: LAMTOR/Ragulator is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning.

In vitro reconstitution and experiments with site-directed mutagenesis defined the physiological importance of LAMTOR1 in assembling the remaining components to ensure fidelity of mTORC1 signaling.
Title: Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling.

Study found that NF1 negatively regulates mTOR signaling in a LAMTOR1-dependent manner. In addition, the cell growth and survival of NF1-deficient cells have become dependent on hyperactivation of the mTOR pathway, and the tumorigenic properties of these cells have become dependent on LAMTOR1.
Title: Clustered, Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9-coupled Affinity Purification/Mass Spectrometry Analysis Revealed a Novel Role of Neurofibromin in mTOR Signaling.

Western blot experiments designed to detect flotillin 2, TMEM256, Rab3B and LAMTOR1 showed that the level of these proteins was higher in urinary exosomes from prostate cancer patients compared to healthy males
Title: Exosomal proteins as prostate cancer biomarkers in urine: From mass spectrometry discovery to immunoassay-based validation.

Data suggest that ablation of p18/LAMTOR1 suppresses starvation-induced cell death by stimulating autophagy through modulation of p27(kip1) activity.
Title: Depletion of p18/LAMTOR1 promotes cell survival via activation of p27(kip1) -dependent autophagy under starvation.

The following LAMTOR1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LAMTOR1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09392	NM_017907.3 Latest version!	Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 (LAMTOR1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu09392	NM_017907.2	Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 (LAMTOR1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LAMTOR1 ( NM_017907.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_060377.1 Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 (LAMTOR1), mRNA.

Price & Availability↑

CloneID	OHu09392
Clone ID Related Accession (Same CDS sequence)	NM_017907.3 , NM_017907.2
Accession Version	NM_017907.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 486bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	ragulator complex protein LAMTOR1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX381569.2, AK000632.1 and BC001706.1. On Nov 23, 2018 this sequence version replaced NM_017907.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.21511.1, SRR5189655.16392.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2146236, SAMEA2146411 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000278671.10/ ENSP00000278671.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGGTGCT GCTACAGCAG CGAGAACGAG GACTCGGACC AGGACCGAGA GGAGCGGAAG 
CTGCTGCTGG ACCCTAGCAG CCCCCCTACC AAAGCTCTCA ATGGAGCCGA GCCCAACTAC 
CACAGCCTGC CTTCCGCTCG CACTGATGAG CAGGCCCTGC TCTCTTCCAT CCTTGCCAAG 
ACAGCCAGCA ACATCATTGA TGTGTCTGCT GCAGACTCAC AGGGCATGGA GCAGCATGAG 
TACATGGACC GTGCCAGGCA GTACAGCACC CGCTTGGCTG TGCTGAGCAG CAGCCTGACC 
CATTGGAAGA AGCTGCCACC GCTGCCGTCT CTTACCAGCC AGCCCCACCA AGTGCTGGCC 
AGTGAGCCCA TCCCGTTCTC TGATTTGCAG CAGGTCTCCA GGATAGCTGC TTATGCCTAC 
AGTGCACTTT CTCAGATCCG TGTGGACGCA AAAGAGGAGC TGGTTGTACA GTTTGGGATC 
CCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060377.1
CDS	74..559
Translation	MGCCYSSENEDSDQDREERKLLLDPSSPPTKALNGAEPNYHSLPSARTDEQALLSSILAKTASNIIDVSAADSQGMEQHEYMDRARQYSTRLAVLSSSLTHWKKLPPLPSLTSQPHQVLASEPIPFSDLQQVSRIAAYAYSALSQIRVDAKEELVVQFGIP

Target ORF information:

RefSeq Version	NM_017907.3
Organism	Homo sapiens(human)
Definition	Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 (LAMTOR1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017907.3

ORF Insert Sequence:

ATGGGGTGCT GCTACAGCAG CGAGAACGAG GACTCGGACC AGGACCGAGA GGAGCGGAAG 
CTGCTGCTGG ACCCTAGCAG CCCCCCTACC AAAGCTCTCA ATGGAGCCGA GCCCAACTAC 
CACAGCCTGC CTTCCGCTCG CACTGATGAG CAGGCCCTGC TCTCTTCCAT CCTTGCCAAG 
ACAGCCAGCA ACATCATTGA TGTGTCTGCT GCAGACTCAC AGGGCATGGA GCAGCATGAG 
TACATGGACC GTGCCAGGCA GTACAGCACC CGCTTGGCTG TGCTGAGCAG CAGCCTGACC 
CATTGGAAGA AGCTGCCACC GCTGCCGTCT CTTACCAGCC AGCCCCACCA AGTGCTGGCC 
AGTGAGCCCA TCCCGTTCTC TGATTTGCAG CAGGTCTCCA GGATAGCTGC TTATGCCTAC 
AGTGCACTTT CTCAGATCCG TGTGGACGCA AAAGAGGAGC TGGTTGTACA GTTTGGGATC 
CCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LAMTOR1 ( NM_017907.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_060377.1 Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 (LAMTOR1), mRNA.

Price & Availability↑

CloneID	OHu09392
Clone ID Related Accession (Same CDS sequence)	NM_017907.3 , NM_017907.2
Accession Version	NM_017907.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 486bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-10
Organism	Homo sapiens(human)
Product	ragulator complex protein LAMTOR1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX381569.2, AK000632.1 and BC001706.1. On Jun 9, 2010 this sequence version replaced NM_017907.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.701636.1, SRR1163655.46025.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2146236, SAMEA2146411 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGTGCT GCTACAGCAG CGAGAACGAG GACTCGGACC AGGACCGAGA GGAGCGGAAG 
CTGCTGCTGG ACCCTAGCAG CCCCCCTACC AAAGCTCTCA ATGGAGCCGA GCCCAACTAC 
CACAGCCTGC CTTCCGCTCG CACTGATGAG CAGGCCCTGC TCTCTTCCAT CCTTGCCAAG 
ACAGCCAGCA ACATCATTGA TGTGTCTGCT GCAGACTCAC AGGGCATGGA GCAGCATGAG 
TACATGGACC GTGCCAGGCA GTACAGCACC CGCTTGGCTG TGCTGAGCAG CAGCCTGACC 
CATTGGAAGA AGCTGCCACC GCTGCCGTCT CTTACCAGCC AGCCCCACCA AGTGCTGGCC 
AGTGAGCCCA TCCCGTTCTC TGATTTGCAG CAGGTCTCCA GGATAGCTGC TTATGCCTAC 
AGTGCACTTT CTCAGATCCG TGTGGACGCA AAAGAGGAGC TGGTTGTACA GTTTGGGATC 
CCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060377.1
CDS	164..649
Translation	MGCCYSSENEDSDQDREERKLLLDPSSPPTKALNGAEPNYHSLPSARTDEQALLSSILAKTASNIIDVSAADSQGMEQHEYMDRARQYSTRLAVLSSSLTHWKKLPPLPSLTSQPHQVLASEPIPFSDLQQVSRIAAYAYSALSQIRVDAKEELVVQFGIP

Target ORF information:

RefSeq Version	NM_017907.2
Organism	Homo sapiens(human)
Definition	Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 (LAMTOR1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017907.2

ORF Insert Sequence:

ATGGGGTGCT GCTACAGCAG CGAGAACGAG GACTCGGACC AGGACCGAGA GGAGCGGAAG 
CTGCTGCTGG ACCCTAGCAG CCCCCCTACC AAAGCTCTCA ATGGAGCCGA GCCCAACTAC 
CACAGCCTGC CTTCCGCTCG CACTGATGAG CAGGCCCTGC TCTCTTCCAT CCTTGCCAAG 
ACAGCCAGCA ACATCATTGA TGTGTCTGCT GCAGACTCAC AGGGCATGGA GCAGCATGAG 
TACATGGACC GTGCCAGGCA GTACAGCACC CGCTTGGCTG TGCTGAGCAG CAGCCTGACC 
CATTGGAAGA AGCTGCCACC GCTGCCGTCT CTTACCAGCC AGCCCCACCA AGTGCTGGCC 
AGTGAGCCCA TCCCGTTCTC TGATTTGCAG CAGGTCTCCA GGATAGCTGC TTATGCCTAC 
AGTGCACTTT CTCAGATCCG TGTGGACGCA AAAGAGGAGC TGGTTGTACA GTTTGGGATC 
CCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

LAMTOR/Ragulator is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning.
The Journal of cell biology216(12)4199-4215(2017 Dec)
Filipek PA,de Araujo MEG,Vogel GF,De Smet CH,Eberharter D,Rebsamen M,Rudashevskaya EL,Kremser L,Yordanov T,Tschaikner P,F?rnrohr BG,Lechner S,Dunzendorfer-Matt T,Scheffzek K,Bennett KL,Superti-Furga G,Lindner HH,Stasyk T,Huber LA

Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling.
Science (New York, N.Y.)358(6361)377-381(2017 10)
de Araujo MEG,Naschberger A,F?rnrohr BG,Stasyk T,Dunzendorfer-Matt T,Lechner S,Welti S,Kremser L,Shivalingaiah G,Offterdinger M,Lindner HH,Huber LA,Scheffzek K

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LAMTOR1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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