CLN6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CLN6
Entrez Gene ID	54982
Full Name	CLN6, transmembrane ER protein
Synonyms	CLN4A,HsT18960,nclf
General protein information	Preferred Names CLN6, transmembrane ER protein Names ceroid-lipofuscinosis neuronal protein 6 ceroid-lipofuscinosis neuronal 6 late infantile ceroid-lipofuscinosis, neuronal 6, late infantile
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q23
Summary	This gene is one of eight which have been associated with neuronal ceroid lipofuscinoses (NCL). Also referred to as Batten disease, NCL comprises a class of autosomal recessive, neurodegenerative disorders affecting children. The genes responsible likely encode proteins involved in the degradation of post-translationally modified proteins in lysosomes. The primary defect in NCL disorders is thought to be associated with lysosomal storage function. [provided by RefSeq, Oct 2008].
Disorder MIM:	606725
Disorder Html:	Ceroid lipofuscinosis, neuronal, 6, 601780 (3); Ceroid lipofuscinosis, neuronal, Kufs type, adult onset, 204300 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_017882.2	NP_060352.1	ceroid-lipofuscinosis neuronal protein 6
NM_017882.3	NP_060352.1	ceroid-lipofuscinosis neuronal protein 6

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	cln6a	NP_001005982.1
Xenopus tropicalis (tropical clawed frog)	cln6	NP_001120230.1
Canis lupus familiaris (dog)	CLN6	NP_001011888.1
Mus musculus (house mouse)	Cln6	NP_001028347.1
Homo sapiens (human)	CLN6	NP_060352.1
Bos taurus (cattle)	CLN6	NP_001103454.1
Rattus norvegicus (Norway rat)	Cln6	NP_001178723.1
Gallus gallus (chicken)	CLN6	NP_001264557.1

Gene Ontology
Bibliography

Related articles in PubMed

Identification of CLN6 as a molecular entity of endoplasmic reticulum-driven anti-aggregate activity.
Yamashita A, Hiraki Y, Yamazaki T
Biochemical and biophysical research communications487(4)917-922(2017 06)

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M
Cell164(4)805-17(2016 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The CLN6 is not only a molecular entity of the anti-aggregate activity conferred by the ER manipulation using TMalphaBC, but also serves as a potential target of therapeutic interventions.
Title: Identification of CLN6 as a molecular entity of endoplasmic reticulum-driven anti-aggregate activity.

describe the spectrum of clinical and neurophysiologic features associated with mutations of CLN6.
Title: Electroclinical spectrum of the neuronal ceroid lipofuscinoses associated with CLN6 mutations.

study demonstrates the central role of the metal transporter, Zip7, in the aberrant biometal metabolism of CLN6 variants of Neuronal ceroid lipofuscinoses.
Title: Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder.

The study describes the first report in the North of Morocco of the CLN6 p.I154del mutation in 3 patients belonging to a large consanguineous family.
Title: CLN6 p.I154del mutation causing late infantile neuronal ceroid lipofuscinosis in a large consanguineous Moroccan family.

our results add CLN6 to the genetic mutations causing teenage-onset progressive myoclonus epilepsy
Title: Mutation of the CLN6 gene in teenage-onset progressive myoclonus epilepsy.

The following CLN6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CLN6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26286	NM_017882.3 Latest version!	Homo sapiens CLN6 transmembrane ER protein (CLN6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu26286	NM_017882.2	Homo sapiens CLN6, transmembrane ER protein (CLN6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CLN6 ( NM_017882.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_060352.1 Homo sapiens CLN6, transmembrane ER protein (CLN6), mRNA.

Price & Availability↑

CloneID	OHu26286
Clone ID Related Accession (Same CDS sequence)	NM_017882.2 , NM_017882.3
Accession Version	NM_017882.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 936bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	ceroid-lipofuscinosis neuronal protein 6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM149330.1, AK027604.1, BC013130.1, CN427564.1, BC010849.1 and CA446197.1. This sequence is a reference standard in the RefSeqGene project. On Oct 17, 2008 this sequence version replaced NM_017882.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK000568.1, SRR1163658.154690.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGCGA CGCGGAGGCG GCAGCACCTG GGAGCGACGG GCGGCCCAGG CGCGCAGCTG 
GGCGCCTCCT TCCTGCAGGC CAGGCATGGC TCTGTGAGCG CTGATGAGGC TGCCCGCACG 
GCTCCCTTCC ACCTCGACCT CTGGTTCTAC TTCACACTGC AGAACTGGGT TCTGGACTTT 
GGGCGTCCCA TTGCCATGCT GGTATTCCCT CTCGAGTGGT TTCCACTCAA CAAGCCCAGT 
GTTGGGGACT ACTTCCACAT GGCCTACAAC GTCATCACGC CCTTTCTCTT GCTCAAGCTC 
ATCGAGCGGT CCCCCCGCAC CCTGCCACGC TCCATCACGT ACGTGAGCAT CATCATCTTC 
ATCATGGGTG CCAGCATCCA CCTGGTGGGT GACTCTGTCA ACCACCGCCT GCTCTTCAGT 
GGCTACCAGC ACCACCTGTC TGTCCGTGAG AACCCCATCA TCAAGAATCT CAAGCCGGAG 
ACGCTGATCG ACTCCTTTGA GCTGCTCTAC TATTATGATG AGTACCTGGG TCACTGCATG 
TGGTACATCC CCTTCTTCCT CATCCTCTTC ATGTACTTCA GCGGCTGCTT TACTGCCTCT 
AAAGCTGAGA GCTTGATTCC AGGGCCTGCC CTGCTCCTGG TGGCACCCAG TGGCCTGTAC 
TACTGGTACC TGGTCACCGA GGGCCAGATC TTCATCCTCT TCATCTTCAC CTTCTTCGCC 
ATGCTGGCCC TCGTCCTGCA CCAGAAGCGC AAGCGCCTCT TCCTGGACAG CAACGGCCTC 
TTCCTCTTCT CCTCCTTCGC ACTGACCCTC TTGCTTGTGG CGCTCTGGGT CGCCTGGCTG 
TGGAATGACC CTGTTCTCAG GAAGAAGTAC CCGGGTGTCA TCTACGTCCC TGAGCCCTGG 
GCTTTCTACA CCCTTCACGT CAGCAGTCGG CACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060352.1
CDS	159..1094
Translation	MEATRRRQHLGATGGPGAQLGASFLQARHGSVSADEAARTAPFHLDLWFYFTLQNWVLDFGRPIAMLVFPLEWFPLNKPSVGDYFHMAYNVITPFLLLKLIERSPRTLPRSITYVSIIIFIMGASIHLVGDSVNHRLLFSGYQHHLSVRENPIIKNLKPETLIDSFELLYYYDEYLGHCMWYIPFFLILFMYFSGCFTASKAESLIPGPALLLVAPSGLYYWYLVTEGQIFILFIFTFFAMLALVLHQKRKRLFLDSNGLFLFSSFALTLLLVALWVAWLWNDPVLRKKYPGVIYVPEPWAFYTLHVSSRH

Target ORF information:

RefSeq Version	NM_017882.2
Organism	Homo sapiens(human)
Definition	Homo sapiens CLN6, transmembrane ER protein (CLN6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017882.2

ORF Insert Sequence:

ATGGAGGCGA CGCGGAGGCG GCAGCACCTG GGAGCGACGG GCGGCCCAGG CGCGCAGCTG 
GGCGCCTCCT TCCTGCAGGC CAGGCATGGC TCTGTGAGCG CTGATGAGGC TGCCCGCACG 
GCTCCCTTCC ACCTCGACCT CTGGTTCTAC TTCACACTGC AGAACTGGGT TCTGGACTTT 
GGGCGTCCCA TTGCCATGCT GGTATTCCCT CTCGAGTGGT TTCCACTCAA CAAGCCCAGT 
GTTGGGGACT ACTTCCACAT GGCCTACAAC GTCATCACGC CCTTTCTCTT GCTCAAGCTC 
ATCGAGCGGT CCCCCCGCAC CCTGCCACGC TCCATCACGT ACGTGAGCAT CATCATCTTC 
ATCATGGGTG CCAGCATCCA CCTGGTGGGT GACTCTGTCA ACCACCGCCT GCTCTTCAGT 
GGCTACCAGC ACCACCTGTC TGTCCGTGAG AACCCCATCA TCAAGAATCT CAAGCCGGAG 
ACGCTGATCG ACTCCTTTGA GCTGCTCTAC TATTATGATG AGTACCTGGG TCACTGCATG 
TGGTACATCC CCTTCTTCCT CATCCTCTTC ATGTACTTCA GCGGCTGCTT TACTGCCTCT 
AAAGCTGAGA GCTTGATTCC AGGGCCTGCC CTGCTCCTGG TGGCACCCAG TGGCCTGTAC 
TACTGGTACC TGGTCACCGA GGGCCAGATC TTCATCCTCT TCATCTTCAC CTTCTTCGCC 
ATGCTGGCCC TCGTCCTGCA CCAGAAGCGC AAGCGCCTCT TCCTGGACAG CAACGGCCTC 
TTCCTCTTCT CCTCCTTCGC ACTGACCCTC TTGCTTGTGG CGCTCTGGGT CGCCTGGCTG 
TGGAATGACC CTGTTCTCAG GAAGAAGTAC CCGGGTGTCA TCTACGTCCC TGAGCCCTGG 
GCTTTCTACA CCCTTCACGT CAGCAGTCGG CACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLN6 ( NM_017882.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_060352.1 Homo sapiens CLN6 transmembrane ER protein (CLN6), mRNA.

Price & Availability↑

CloneID	OHu26286
Clone ID Related Accession (Same CDS sequence)	NM_017882.2 , NM_017882.3
Accession Version	NM_017882.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 936bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-26
Organism	Homo sapiens(human)
Product	ceroid-lipofuscinosis neuronal protein 6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM149330.1, AK027604.1, BC013130.1, CN427564.1, BC010849.1 and CA446197.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_017882.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK000568.1, SRR1163658.154690.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000249806.11/ ENSP00000249806.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGGCGA CGCGGAGGCG GCAGCACCTG GGAGCGACGG GCGGCCCAGG CGCGCAGCTG 
GGCGCCTCCT TCCTGCAGGC CAGGCATGGC TCTGTGAGCG CTGATGAGGC TGCCCGCACG 
GCTCCCTTCC ACCTCGACCT CTGGTTCTAC TTCACACTGC AGAACTGGGT TCTGGACTTT 
GGGCGTCCCA TTGCCATGCT GGTATTCCCT CTCGAGTGGT TTCCACTCAA CAAGCCCAGT 
GTTGGGGACT ACTTCCACAT GGCCTACAAC GTCATCACGC CCTTTCTCTT GCTCAAGCTC 
ATCGAGCGGT CCCCCCGCAC CCTGCCACGC TCCATCACGT ACGTGAGCAT CATCATCTTC 
ATCATGGGTG CCAGCATCCA CCTGGTGGGT GACTCTGTCA ACCACCGCCT GCTCTTCAGT 
GGCTACCAGC ACCACCTGTC TGTCCGTGAG AACCCCATCA TCAAGAATCT CAAGCCGGAG 
ACGCTGATCG ACTCCTTTGA GCTGCTCTAC TATTATGATG AGTACCTGGG TCACTGCATG 
TGGTACATCC CCTTCTTCCT CATCCTCTTC ATGTACTTCA GCGGCTGCTT TACTGCCTCT 
AAAGCTGAGA GCTTGATTCC AGGGCCTGCC CTGCTCCTGG TGGCACCCAG TGGCCTGTAC 
TACTGGTACC TGGTCACCGA GGGCCAGATC TTCATCCTCT TCATCTTCAC CTTCTTCGCC 
ATGCTGGCCC TCGTCCTGCA CCAGAAGCGC AAGCGCCTCT TCCTGGACAG CAACGGCCTC 
TTCCTCTTCT CCTCCTTCGC ACTGACCCTC TTGCTTGTGG CGCTCTGGGT CGCCTGGCTG 
TGGAATGACC CTGTTCTCAG GAAGAAGTAC CCGGGTGTCA TCTACGTCCC TGAGCCCTGG 
GCTTTCTACA CCCTTCACGT CAGCAGTCGG CACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060352.1
CDS	145..1080
Translation	MEATRRRQHLGATGGPGAQLGASFLQARHGSVSADEAARTAPFHLDLWFYFTLQNWVLDFGRPIAMLVFPLEWFPLNKPSVGDYFHMAYNVITPFLLLKLIERSPRTLPRSITYVSIIIFIMGASIHLVGDSVNHRLLFSGYQHHLSVRENPIIKNLKPETLIDSFELLYYYDEYLGHCMWYIPFFLILFMYFSGCFTASKAESLIPGPALLLVAPSGLYYWYLVTEGQIFILFIFTFFAMLALVLHQKRKRLFLDSNGLFLFSSFALTLLLVALWVAWLWNDPVLRKKYPGVIYVPEPWAFYTLHVSSRH

Target ORF information:

RefSeq Version	NM_017882.3
Organism	Homo sapiens(human)
Definition	Homo sapiens CLN6 transmembrane ER protein (CLN6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017882.3

ORF Insert Sequence:

ATGGAGGCGA CGCGGAGGCG GCAGCACCTG GGAGCGACGG GCGGCCCAGG CGCGCAGCTG 
GGCGCCTCCT TCCTGCAGGC CAGGCATGGC TCTGTGAGCG CTGATGAGGC TGCCCGCACG 
GCTCCCTTCC ACCTCGACCT CTGGTTCTAC TTCACACTGC AGAACTGGGT TCTGGACTTT 
GGGCGTCCCA TTGCCATGCT GGTATTCCCT CTCGAGTGGT TTCCACTCAA CAAGCCCAGT 
GTTGGGGACT ACTTCCACAT GGCCTACAAC GTCATCACGC CCTTTCTCTT GCTCAAGCTC 
ATCGAGCGGT CCCCCCGCAC CCTGCCACGC TCCATCACGT ACGTGAGCAT CATCATCTTC 
ATCATGGGTG CCAGCATCCA CCTGGTGGGT GACTCTGTCA ACCACCGCCT GCTCTTCAGT 
GGCTACCAGC ACCACCTGTC TGTCCGTGAG AACCCCATCA TCAAGAATCT CAAGCCGGAG 
ACGCTGATCG ACTCCTTTGA GCTGCTCTAC TATTATGATG AGTACCTGGG TCACTGCATG 
TGGTACATCC CCTTCTTCCT CATCCTCTTC ATGTACTTCA GCGGCTGCTT TACTGCCTCT 
AAAGCTGAGA GCTTGATTCC AGGGCCTGCC CTGCTCCTGG TGGCACCCAG TGGCCTGTAC 
TACTGGTACC TGGTCACCGA GGGCCAGATC TTCATCCTCT TCATCTTCAC CTTCTTCGCC 
ATGCTGGCCC TCGTCCTGCA CCAGAAGCGC AAGCGCCTCT TCCTGGACAG CAACGGCCTC 
TTCCTCTTCT CCTCCTTCGC ACTGACCCTC TTGCTTGTGG CGCTCTGGGT CGCCTGGCTG 
TGGAATGACC CTGTTCTCAG GAAGAAGTAC CCGGGTGTCA TCTACGTCCC TGAGCCCTGG 
GCTTTCTACA CCCTTCACGT CAGCAGTCGG CACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of CLN6 as a molecular entity of endoplasmic reticulum-driven anti-aggregate activity.
Biochemical and biophysical research communications487(4)917-922(2017 06)
Yamashita A,Hiraki Y,Yamazaki T

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Cell164(4)805-17(2016 Feb)
Yang X,Coulombe-Huntington J,Kang S,Sheynkman GM,Hao T,Richardson A,Sun S,Yang F,Shen YA,Murray RR,Spirohn K,Begg BE,Duran-Frigola M,MacWilliams A,Pevzner SJ,Zhong Q,Trigg SA,Tam S,Ghamsari L,Sahni N,Yi S,Rodriguez MD,Balcha D,Tan G,Costanzo M,Andrews B,Boone C,Zhou XJ,Salehi-Ashtiani K,Charloteaux B,Chen AA,Calderwood MA,Aloy P,Roth FP,Hill DE,Iakoucheva LM,Xia Y,Vidal M

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CLN6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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