Gene Symbol | PPM1B |
Entrez Gene ID | 5495 |
Full Name | protein phosphatase, Mg2+/Mn2+ dependent 1B |
Synonyms | PP2C-beta,PP2C-beta-X,PP2CB,PP2CBETA,PPC2BETAX |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008]. |
Disorder MIM: |