RNF125 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RNF125
Entrez Gene ID	54941
Full Name	ring finger protein 125
Synonyms	TNORS,TRAC-1,TRAC1
General protein information	Preferred Names ring finger protein 125 Names E3 ubiquitin-protein ligase RNF125 T-cell RING activation protein 1 T-cell ring protein identified in activation screen ring finger protein 125, E3 ubiquitin protein ligase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 18 Map Location: 18q12.1
Summary	This gene encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is primarily localized to intracellular membrane systems. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway. [provided by RefSeq, Mar 2012].
Disorder MIM:	610432
Disorder Html:	Tenorio syndrome, 616260 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_011526045.2	XP_011524347.1	E3 ubiquitin-protein ligase RNF125 isoform X1
XM_011526046.3	XP_011524348.1	E3 ubiquitin-protein ligase RNF125 isoform X2
XM_011526047.3	XP_011524349.1	E3 ubiquitin-protein ligase RNF125 isoform X3
NM_017831.4	NP_060301.2	E3 ubiquitin-protein ligase RNF125
NM_017831.3	NP_060301.2	E3 ubiquitin-protein ligase RNF125
XM_011526045.3	XP_011524347.1	E3 ubiquitin-protein ligase RNF125 isoform X1
XM_011526046.2	XP_011524348.1	E3 ubiquitin-protein ligase RNF125 isoform X2
XM_011526047.2	XP_011524349.1	E3 ubiquitin-protein ligase RNF125 isoform X3

Pathways from BioSystems

Homologies

Bos taurus (cattle)	RNF125	NP_001192788.1
Xenopus tropicalis (tropical clawed frog)	rnf125	XP_002934166.1
Canis lupus familiaris (dog)	RNF125	XP_547620.3
Pan troglodytes (chimpanzee)	RNF125	XP_001160124.1
Rattus norvegicus (Norway rat)	Rnf125	NP_001101894.1
Homo sapiens (human)	RNF125	NP_060301.2
	RNF125	XP_001099929.1

Gene Ontology
Bibliography

Related articles in PubMed

E3 Ubiquitin Ligase RNF125 Activates Interleukin-36 Receptor Signaling and Contributes to Its Turnover.
Saha SS, Caviness G, Yi G, Raymond EL, Mbow ML, Kao CC
Journal of innate immunity(2017 Nov)

Ring finger protein 125, as a potential highly aggressive and unfavorable prognostic biomarker, promotes the invasion and metastasis of human gallbladder cancers via activating the TGF- ?1-SMAD3-ID1 signaling pathway.
Liu ZY, Cao J, Zhang JT, Xu GL, Li XP, Wang FT, Ansari KH, Mohamed H, Fan YZ
Oncotarget8(30)49897-49914(2017 Jul)

The Ubiquitin Ligase RNF125 Targets Innate Immune Adaptor Protein TRIM14 for Ubiquitination and Degradation.
Jia X, Zhou H, Wu C, Wu Q, Ma S, Wei C, Cao Y, Song J, Zhong H, Zhou Z, Wang J
Journal of immunology (Baltimore, Md. : 1950)198(12)4652-4658(2017 Jun)

A C2HC zinc finger is essential for the RING-E2 interaction of the ubiquitin ligase RNF125.
Bijlmakers MJ, Teixeira JM, Boer R, Mayzel M, Puig-S?rries P, Karlsson G, Coll M, Pons M, Crosas B
Scientific reports629232(2016 Jul)

A non-canonical role of the p97 complex in RIG-I antiviral signaling.
Hao Q, Jiao S, Shi Z, Li C, Meng X, Zhang Z, Wang Y, Song X, Wang W, Zhang R, Zhao Y, Wong CC, Zhou Z
The EMBO journal34(23)2903-20(2015 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

study identifies new gene-type zinc finger protein 125 (RNF125) as a negative regulator of TRIM14 in the innate antiviral immune response
Title: The Ubiquitin Ligase RNF125 Targets Innate Immune Adaptor Protein TRIM14 for Ubiquitination and Degradation.

Results indicate that the nucleotide sequence in the 3' untranslated region (3' UTR) of ring finger protein 125 (RNF125) is a potential microRNA miR-15b targeting site.
Title: MicroRNA-15b Modulates Japanese Encephalitis Virus-Mediated Inflammation via Targeting RNF125.

we identified the downregulation of the ubiquitin ligase RNF125 in BRAFi-resistant melanomas
Title: Downregulation of the Ubiquitin Ligase RNF125 Underlies Resistance of Melanoma Cells to BRAF Inhibitors via JAK1 Deregulation.

studies of the RNF125 pathway point to upregulation of RIG-I-IPS1-MDA5 and/or disruption of the PI3K-AKT and interferon signaling pathways as the putative final effectors
Title: A new overgrowth syndrome is due to mutations in RNF125.

In controls, RNF125 is the highest expressed gene, whereas in HIV infection progressors, RIG-I is either the highest expressed gene or is expressed similarly to RNF125 and TRIM25.
Title: Expression levels of the innate response gene RIG-I and its regulators RNF125 and TRIM25 in HIV-1-infected adult and pediatric individuals.

The following RNF125 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RNF125 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17251	NM_017831.4 Latest version!	Homo sapiens ring finger protein 125 (RNF125), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu68812	XM_011526046.3 Latest version!	Homo sapiens ring finger protein 125 (RNF125), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu68811	XM_011526045.3 Latest version!	Homo sapiens ring finger protein 125 (RNF125), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu68813	XM_011526047.3 Latest version!	Homo sapiens ring finger protein 125 (RNF125), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu17251	NM_017831.3	Homo sapiens ring finger protein 125 (RNF125), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu68811	XM_011526045.2	Homo sapiens ring finger protein 125, E3 ubiquitin protein ligase (RNF125), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu68812	XM_011526046.2	Homo sapiens ring finger protein 125, E3 ubiquitin protein ligase (RNF125), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu68813	XM_011526047.2	Homo sapiens ring finger protein 125, E3 ubiquitin protein ligase (RNF125), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RNF125 ( NM_017831.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_060301.2 Homo sapiens ring finger protein 125 (RNF125), mRNA.

Price & Availability↑

CloneID	OHu17251
Clone ID Related Accession (Same CDS sequence)	NM_017831.4 , NM_017831.3
Accession Version	NM_017831.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 699bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase RNF125
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI666910.1, BC012021.1, AK000463.1 and AC011825.13. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_017831.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.373170.1, SRR1660809.78201.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000217740.4/ ENSP00000217740.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGCTCCG TGCTGAGCAC CGACAGCGGC AAATCGGCGC CCGCCTCTGC CACCGCGCGG 
GCCCTGGAGC GCAGGAGGGA CCCGGAGTTG CCCGTCACGT CCTTCGACTG CGCCGTGTGC 
CTTGAGGTGT TACACCAGCC TGTCCGGACC CGCTGTGGCC ACGTATTCTG CCGTTCCTGT 
ATTGCTACCA GTCTAAAGAA CAACAAGTGG ACCTGTCCTT ATTGCCGGGC ATATCTTCCT 
TCAGAAGGAG TTCCAGCAAC TGATGTAGCC AAAAGAATGA AATCAGAGTA TAAGAACTGC 
GCTGAGTGTG ACACCCTGGT TTGCCTCAGT GAAATGAGGG CACATATTCG GACTTGTCAG 
AAGTACATAG ATAAGTATGG ACCACTACAA GAACTTGAGG AGACAGCAGC AAGGTGTGTA 
TGTCCCTTTT GTCAGAGGGA ACTGTATGAA GACAGCTTGC TGGATCATTG TATTACTCAT 
CACAGATCGG AACGGAGGCC TGTGTTCTGT CCACTTTGCC GTTTAATACC CGATGAGAAT 
CCAAGCAGCT TCAGTGGCAG TTTAATAAGA CATCTGCAAG TTAGTCACAC TTTGTTTTAT 
GATGATTTCA TAGATTTTAA TATAATTGAG GAAGCTCTTA TCCGAAGAGT CTTAGACCGG 
TCACTTCTTG AATATGTGAA TCACTCGAAC ACCACATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060301.2
CDS	40..738
Translation	MGSVLSTDSGKSAPASATARALERRRDPELPVTSFDCAVCLEVLHQPVRTRCGHVFCRSCIATSLKNNKWTCPYCRAYLPSEGVPATDVAKRMKSEYKNCAECDTLVCLSEMRAHIRTCQKYIDKYGPLQELEETAARCVCPFCQRELYEDSLLDHCITHHRSERRPVFCPLCRLIPDENPSSFSGSLIRHLQVSHTLFYDDFIDFNIIEEALIRRVLDRSLLEYVNHSNTT

Target ORF information:

RefSeq Version	NM_017831.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ring finger protein 125 (RNF125), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017831.4

ORF Insert Sequence:

ATGGGCTCCG TGCTGAGCAC CGACAGCGGC AAATCGGCGC CCGCCTCTGC CACCGCGCGG 
GCCCTGGAGC GCAGGAGGGA CCCGGAGTTG CCCGTCACGT CCTTCGACTG CGCCGTGTGC 
CTTGAGGTGT TACACCAGCC TGTCCGGACC CGCTGTGGCC ACGTATTCTG CCGTTCCTGT 
ATTGCTACCA GTCTAAAGAA CAACAAGTGG ACCTGTCCTT ATTGCCGGGC ATATCTTCCT 
TCAGAAGGAG TTCCAGCAAC TGATGTAGCC AAAAGAATGA AATCAGAGTA TAAGAACTGC 
GCTGAGTGTG ACACCCTGGT TTGCCTCAGT GAAATGAGGG CACATATTCG GACTTGTCAG 
AAGTACATAG ATAAGTATGG ACCACTACAA GAACTTGAGG AGACAGCAGC AAGGTGTGTA 
TGTCCCTTTT GTCAGAGGGA ACTGTATGAA GACAGCTTGC TGGATCATTG TATTACTCAT 
CACAGATCGG AACGGAGGCC TGTGTTCTGT CCACTTTGCC GTTTAATACC CGATGAGAAT 
CCAAGCAGCT TCAGTGGCAG TTTAATAAGA CATCTGCAAG TTAGTCACAC TTTGTTTTAT 
GATGATTTCA TAGATTTTAA TATAATTGAG GAAGCTCTTA TCCGAAGAGT CTTAGACCGG 
TCACTTCTTG AATATGTGAA TCACTCGAAC ACCACATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RNF125 ( NM_017831.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_060301.2 Homo sapiens ring finger protein 125 (RNF125), mRNA.

Price & Availability↑

CloneID	OHu17251
Clone ID Related Accession (Same CDS sequence)	NM_017831.4 , NM_017831.3
Accession Version	NM_017831.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 699bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase RNF125
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI666910.1, BC012021.1, AK000463.1 and AC011825.13. This sequence is a reference standard in the RefSeqGene project. On Sep 28, 2006 this sequence version replaced NM_017831.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK000463.1, SRR1163655.373170.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCTCCG TGCTGAGCAC CGACAGCGGC AAATCGGCGC CCGCCTCTGC CACCGCGCGG 
GCCCTGGAGC GCAGGAGGGA CCCGGAGTTG CCCGTCACGT CCTTCGACTG CGCCGTGTGC 
CTTGAGGTGT TACACCAGCC TGTCCGGACC CGCTGTGGCC ACGTATTCTG CCGTTCCTGT 
ATTGCTACCA GTCTAAAGAA CAACAAGTGG ACCTGTCCTT ATTGCCGGGC ATATCTTCCT 
TCAGAAGGAG TTCCAGCAAC TGATGTAGCC AAAAGAATGA AATCAGAGTA TAAGAACTGC 
GCTGAGTGTG ACACCCTGGT TTGCCTCAGT GAAATGAGGG CACATATTCG GACTTGTCAG 
AAGTACATAG ATAAGTATGG ACCACTACAA GAACTTGAGG AGACAGCAGC AAGGTGTGTA 
TGTCCCTTTT GTCAGAGGGA ACTGTATGAA GACAGCTTGC TGGATCATTG TATTACTCAT 
CACAGATCGG AACGGAGGCC TGTGTTCTGT CCACTTTGCC GTTTAATACC CGATGAGAAT 
CCAAGCAGCT TCAGTGGCAG TTTAATAAGA CATCTGCAAG TTAGTCACAC TTTGTTTTAT 
GATGATTTCA TAGATTTTAA TATAATTGAG GAAGCTCTTA TCCGAAGAGT CTTAGACCGG 
TCACTTCTTG AATATGTGAA TCACTCGAAC ACCACATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060301.2
CDS	383..1081
Translation	MGSVLSTDSGKSAPASATARALERRRDPELPVTSFDCAVCLEVLHQPVRTRCGHVFCRSCIATSLKNNKWTCPYCRAYLPSEGVPATDVAKRMKSEYKNCAECDTLVCLSEMRAHIRTCQKYIDKYGPLQELEETAARCVCPFCQRELYEDSLLDHCITHHRSERRPVFCPLCRLIPDENPSSFSGSLIRHLQVSHTLFYDDFIDFNIIEEALIRRVLDRSLLEYVNHSNTT

Target ORF information:

RefSeq Version	NM_017831.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ring finger protein 125 (RNF125), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017831.3

ORF Insert Sequence:

ATGGGCTCCG TGCTGAGCAC CGACAGCGGC AAATCGGCGC CCGCCTCTGC CACCGCGCGG 
GCCCTGGAGC GCAGGAGGGA CCCGGAGTTG CCCGTCACGT CCTTCGACTG CGCCGTGTGC 
CTTGAGGTGT TACACCAGCC TGTCCGGACC CGCTGTGGCC ACGTATTCTG CCGTTCCTGT 
ATTGCTACCA GTCTAAAGAA CAACAAGTGG ACCTGTCCTT ATTGCCGGGC ATATCTTCCT 
TCAGAAGGAG TTCCAGCAAC TGATGTAGCC AAAAGAATGA AATCAGAGTA TAAGAACTGC 
GCTGAGTGTG ACACCCTGGT TTGCCTCAGT GAAATGAGGG CACATATTCG GACTTGTCAG 
AAGTACATAG ATAAGTATGG ACCACTACAA GAACTTGAGG AGACAGCAGC AAGGTGTGTA 
TGTCCCTTTT GTCAGAGGGA ACTGTATGAA GACAGCTTGC TGGATCATTG TATTACTCAT 
CACAGATCGG AACGGAGGCC TGTGTTCTGT CCACTTTGCC GTTTAATACC CGATGAGAAT 
CCAAGCAGCT TCAGTGGCAG TTTAATAAGA CATCTGCAAG TTAGTCACAC TTTGTTTTAT 
GATGATTTCA TAGATTTTAA TATAATTGAG GAAGCTCTTA TCCGAAGAGT CTTAGACCGG 
TCACTTCTTG AATATGTGAA TCACTCGAAC ACCACATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RNF125 ( XM_011526046.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011524348.1 Homo sapiens ring finger protein 125 (RNF125), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu68812
Clone ID Related Accession (Same CDS sequence)	XM_011526046.3 , XM_011526046.2
Accession Version	XM_011526046.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 591bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase RNF125 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000018.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011526046.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCTCCG TGCTGAGCAC CGACAGCGGC AAATCGGCGC CCGCCTCTGC CACCGCGCGG 
GCCCTGGAGC GCAGGAGGGA CCCGGAGTTG CCCGTCACGT CCTTCGACTG CGCCGTGTGC 
CTTGAGGTGT TACACCAGCC TGTCCGGACC CGCTGTGGCC ACGTATTCTG CCGTTCCTGT 
ATTGCTACCA GTCTAAAGAA CAACAAGTGG ACCTGTCCTT ATTGCCGGGC ATATCTTCCT 
TCAGAAGGAG TTCCAGCAAC TGATGTAGCC AAAAGAATGA AATCAGAGTA TAAGAACTGC 
GCTGAGTGTG ACACCCTGGT TTGCCTCAGT GAAATGAGGG CACATATTCG GACTTGTCAG 
AAGTACATAG ATAAGTATGG ACCACTACAA GAACTTGAGG AGACAGCAGC AAGGTGTGTA 
TGTCCCTTTT GTCAGAGGGA ACTGTATGAA GACAGCTTGC TGGATCATTG TATTACTCAT 
CACAGATCGG AACGGAGGCC TGTGGATTTT AATATAATTG AGGAAGCTCT TATCCGAAGA 
GTCTTAGACC GGTCACTTCT TGAATATGTG AATCACTCGA ACACCACATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011524348.1
CDS	280..870
Translation	MGSVLSTDSGKSAPASATARALERRRDPELPVTSFDCAVCLEVLHQPVRTRCGHVFCRSCIATSLKNNKWTCPYCRAYLPSEGVPATDVAKRMKSEYKNCAECDTLVCLSEMRAHIRTCQKYIDKYGPLQELEETAARCVCPFCQRELYEDSLLDHCITHHRSERRPVDFNIIEEALIRRVLDRSLLEYVNHSNTT

Target ORF information:

RefSeq Version	XM_011526046.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ring finger protein 125 (RNF125), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011526046.3

ORF Insert Sequence:

ATGGGCTCCG TGCTGAGCAC CGACAGCGGC AAATCGGCGC CCGCCTCTGC CACCGCGCGG 
GCCCTGGAGC GCAGGAGGGA CCCGGAGTTG CCCGTCACGT CCTTCGACTG CGCCGTGTGC 
CTTGAGGTGT TACACCAGCC TGTCCGGACC CGCTGTGGCC ACGTATTCTG CCGTTCCTGT 
ATTGCTACCA GTCTAAAGAA CAACAAGTGG ACCTGTCCTT ATTGCCGGGC ATATCTTCCT 
TCAGAAGGAG TTCCAGCAAC TGATGTAGCC AAAAGAATGA AATCAGAGTA TAAGAACTGC 
GCTGAGTGTG ACACCCTGGT TTGCCTCAGT GAAATGAGGG CACATATTCG GACTTGTCAG 
AAGTACATAG ATAAGTATGG ACCACTACAA GAACTTGAGG AGACAGCAGC AAGGTGTGTA 
TGTCCCTTTT GTCAGAGGGA ACTGTATGAA GACAGCTTGC TGGATCATTG TATTACTCAT 
CACAGATCGG AACGGAGGCC TGTGGATTTT AATATAATTG AGGAAGCTCT TATCCGAAGA 
GTCTTAGACC GGTCACTTCT TGAATATGTG AATCACTCGA ACACCACATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RNF125 ( XM_011526046.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011524348.1 Homo sapiens ring finger protein 125, E3 ubiquitin protein ligase (RNF125), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu68812
Clone ID Related Accession (Same CDS sequence)	XM_011526046.3 , XM_011526046.2
Accession Version	XM_011526046.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 591bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase RNF125 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000018.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011526046.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCTCCG TGCTGAGCAC CGACAGCGGC AAATCGGCGC CCGCCTCTGC CACCGCGCGG 
GCCCTGGAGC GCAGGAGGGA CCCGGAGTTG CCCGTCACGT CCTTCGACTG CGCCGTGTGC 
CTTGAGGTGT TACACCAGCC TGTCCGGACC CGCTGTGGCC ACGTATTCTG CCGTTCCTGT 
ATTGCTACCA GTCTAAAGAA CAACAAGTGG ACCTGTCCTT ATTGCCGGGC ATATCTTCCT 
TCAGAAGGAG TTCCAGCAAC TGATGTAGCC AAAAGAATGA AATCAGAGTA TAAGAACTGC 
GCTGAGTGTG ACACCCTGGT TTGCCTCAGT GAAATGAGGG CACATATTCG GACTTGTCAG 
AAGTACATAG ATAAGTATGG ACCACTACAA GAACTTGAGG AGACAGCAGC AAGGTGTGTA 
TGTCCCTTTT GTCAGAGGGA ACTGTATGAA GACAGCTTGC TGGATCATTG TATTACTCAT 
CACAGATCGG AACGGAGGCC TGTGGATTTT AATATAATTG AGGAAGCTCT TATCCGAAGA 
GTCTTAGACC GGTCACTTCT TGAATATGTG AATCACTCGA ACACCACATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011524348.1
CDS	33..623
Translation	MGSVLSTDSGKSAPASATARALERRRDPELPVTSFDCAVCLEVLHQPVRTRCGHVFCRSCIATSLKNNKWTCPYCRAYLPSEGVPATDVAKRMKSEYKNCAECDTLVCLSEMRAHIRTCQKYIDKYGPLQELEETAARCVCPFCQRELYEDSLLDHCITHHRSERRPVDFNIIEEALIRRVLDRSLLEYVNHSNTT

Target ORF information:

RefSeq Version	XM_011526046.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ring finger protein 125, E3 ubiquitin protein ligase (RNF125), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011526046.2

ORF Insert Sequence:

ATGGGCTCCG TGCTGAGCAC CGACAGCGGC AAATCGGCGC CCGCCTCTGC CACCGCGCGG 
GCCCTGGAGC GCAGGAGGGA CCCGGAGTTG CCCGTCACGT CCTTCGACTG CGCCGTGTGC 
CTTGAGGTGT TACACCAGCC TGTCCGGACC CGCTGTGGCC ACGTATTCTG CCGTTCCTGT 
ATTGCTACCA GTCTAAAGAA CAACAAGTGG ACCTGTCCTT ATTGCCGGGC ATATCTTCCT 
TCAGAAGGAG TTCCAGCAAC TGATGTAGCC AAAAGAATGA AATCAGAGTA TAAGAACTGC 
GCTGAGTGTG ACACCCTGGT TTGCCTCAGT GAAATGAGGG CACATATTCG GACTTGTCAG 
AAGTACATAG ATAAGTATGG ACCACTACAA GAACTTGAGG AGACAGCAGC AAGGTGTGTA 
TGTCCCTTTT GTCAGAGGGA ACTGTATGAA GACAGCTTGC TGGATCATTG TATTACTCAT 
CACAGATCGG AACGGAGGCC TGTGGATTTT AATATAATTG AGGAAGCTCT TATCCGAAGA 
GTCTTAGACC GGTCACTTCT TGAATATGTG AATCACTCGA ACACCACATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RNF125 ( XM_011526045.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011524347.1 Homo sapiens ring finger protein 125, E3 ubiquitin protein ligase (RNF125), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu68811
Clone ID Related Accession (Same CDS sequence)	XM_011526045.2 , XM_011526045.3
Accession Version	XM_011526045.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 684bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase RNF125 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000018.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011526045.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCTCCG TGCTGAGCAC CGACAGCGGC AAATCGGCGC CCGCCTCTGC CACCGCGCGG 
GCCCTGGAGC GCAGGAGGGA CCCGGAGTTG CCCGTCACGT CCTTCGACTG CGCCGTGTGC 
CTTGAGGTGT TACACCAGCC TGTCCGGACC CGCTGTGGCC ACGTATTCTG CCGTTCCTGT 
ATTGCTACCA GTCTAAAGAA CAACAAGTGG ACCTGTCCTT ATTGCCGGGC ATATCTTCCT 
TCAGAAGGAG TTCCAGCAAC TGATGTAGCC AAAAGAATGA AATCAGAGTA TAAGAACTGC 
GCTGAGTGTG ACACCCTGGT TTGCCTCAGT GAAATGAGGG CACATATTCG GACTTGTCAG 
AAGTACATAG ATAAGTATGG ACCACTACAA GAACTTGAGG AGACAGCAGC AAGGTGTGTA 
TGTCCCTTTT GTCAGAGGGA ACTGTATGAA GACAGCTTGC TGGATCATTG TATTACTCAT 
CACAGATCGG AACGGAGGCC TGTGTTCTGT CCACTTTGCC GTTTAATACC CGATGAGAAT 
CCAAGCAGCT TCAGTGGCAG TTTAATAAGA CATCTGCAAG TTAGTCACAC TTTGTTTTAT 
GATGATTTCA TAGATAACAA TACGAAGATC CACCTGTCTT GCTGCTGCCC AAGACCACAC 
TTCCATCCAC AAGTTCCCCA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011524347.1
CDS	652..1335
Translation	MGSVLSTDSGKSAPASATARALERRRDPELPVTSFDCAVCLEVLHQPVRTRCGHVFCRSCIATSLKNNKWTCPYCRAYLPSEGVPATDVAKRMKSEYKNCAECDTLVCLSEMRAHIRTCQKYIDKYGPLQELEETAARCVCPFCQRELYEDSLLDHCITHHRSERRPVFCPLCRLIPDENPSSFSGSLIRHLQVSHTLFYDDFIDNNTKIHLSCCCPRPHFHPQVPQ

Target ORF information:

RefSeq Version	XM_011526045.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ring finger protein 125, E3 ubiquitin protein ligase (RNF125), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011526045.2

ORF Insert Sequence:

ATGGGCTCCG TGCTGAGCAC CGACAGCGGC AAATCGGCGC CCGCCTCTGC CACCGCGCGG 
GCCCTGGAGC GCAGGAGGGA CCCGGAGTTG CCCGTCACGT CCTTCGACTG CGCCGTGTGC 
CTTGAGGTGT TACACCAGCC TGTCCGGACC CGCTGTGGCC ACGTATTCTG CCGTTCCTGT 
ATTGCTACCA GTCTAAAGAA CAACAAGTGG ACCTGTCCTT ATTGCCGGGC ATATCTTCCT 
TCAGAAGGAG TTCCAGCAAC TGATGTAGCC AAAAGAATGA AATCAGAGTA TAAGAACTGC 
GCTGAGTGTG ACACCCTGGT TTGCCTCAGT GAAATGAGGG CACATATTCG GACTTGTCAG 
AAGTACATAG ATAAGTATGG ACCACTACAA GAACTTGAGG AGACAGCAGC AAGGTGTGTA 
TGTCCCTTTT GTCAGAGGGA ACTGTATGAA GACAGCTTGC TGGATCATTG TATTACTCAT 
CACAGATCGG AACGGAGGCC TGTGTTCTGT CCACTTTGCC GTTTAATACC CGATGAGAAT 
CCAAGCAGCT TCAGTGGCAG TTTAATAAGA CATCTGCAAG TTAGTCACAC TTTGTTTTAT 
GATGATTTCA TAGATAACAA TACGAAGATC CACCTGTCTT GCTGCTGCCC AAGACCACAC 
TTCCATCCAC AAGTTCCCCA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RNF125 ( XM_011526045.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011524347.1 Homo sapiens ring finger protein 125 (RNF125), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu68811
Clone ID Related Accession (Same CDS sequence)	XM_011526045.2 , XM_011526045.3
Accession Version	XM_011526045.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 684bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase RNF125 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000018.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011526045.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCTCCG TGCTGAGCAC CGACAGCGGC AAATCGGCGC CCGCCTCTGC CACCGCGCGG 
GCCCTGGAGC GCAGGAGGGA CCCGGAGTTG CCCGTCACGT CCTTCGACTG CGCCGTGTGC 
CTTGAGGTGT TACACCAGCC TGTCCGGACC CGCTGTGGCC ACGTATTCTG CCGTTCCTGT 
ATTGCTACCA GTCTAAAGAA CAACAAGTGG ACCTGTCCTT ATTGCCGGGC ATATCTTCCT 
TCAGAAGGAG TTCCAGCAAC TGATGTAGCC AAAAGAATGA AATCAGAGTA TAAGAACTGC 
GCTGAGTGTG ACACCCTGGT TTGCCTCAGT GAAATGAGGG CACATATTCG GACTTGTCAG 
AAGTACATAG ATAAGTATGG ACCACTACAA GAACTTGAGG AGACAGCAGC AAGGTGTGTA 
TGTCCCTTTT GTCAGAGGGA ACTGTATGAA GACAGCTTGC TGGATCATTG TATTACTCAT 
CACAGATCGG AACGGAGGCC TGTGTTCTGT CCACTTTGCC GTTTAATACC CGATGAGAAT 
CCAAGCAGCT TCAGTGGCAG TTTAATAAGA CATCTGCAAG TTAGTCACAC TTTGTTTTAT 
GATGATTTCA TAGATAACAA TACGAAGATC CACCTGTCTT GCTGCTGCCC AAGACCACAC 
TTCCATCCAC AAGTTCCCCA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011524347.1
CDS	280..963
Translation	MGSVLSTDSGKSAPASATARALERRRDPELPVTSFDCAVCLEVLHQPVRTRCGHVFCRSCIATSLKNNKWTCPYCRAYLPSEGVPATDVAKRMKSEYKNCAECDTLVCLSEMRAHIRTCQKYIDKYGPLQELEETAARCVCPFCQRELYEDSLLDHCITHHRSERRPVFCPLCRLIPDENPSSFSGSLIRHLQVSHTLFYDDFIDNNTKIHLSCCCPRPHFHPQVPQ

Target ORF information:

RefSeq Version	XM_011526045.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ring finger protein 125 (RNF125), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011526045.3

ORF Insert Sequence:

ATGGGCTCCG TGCTGAGCAC CGACAGCGGC AAATCGGCGC CCGCCTCTGC CACCGCGCGG 
GCCCTGGAGC GCAGGAGGGA CCCGGAGTTG CCCGTCACGT CCTTCGACTG CGCCGTGTGC 
CTTGAGGTGT TACACCAGCC TGTCCGGACC CGCTGTGGCC ACGTATTCTG CCGTTCCTGT 
ATTGCTACCA GTCTAAAGAA CAACAAGTGG ACCTGTCCTT ATTGCCGGGC ATATCTTCCT 
TCAGAAGGAG TTCCAGCAAC TGATGTAGCC AAAAGAATGA AATCAGAGTA TAAGAACTGC 
GCTGAGTGTG ACACCCTGGT TTGCCTCAGT GAAATGAGGG CACATATTCG GACTTGTCAG 
AAGTACATAG ATAAGTATGG ACCACTACAA GAACTTGAGG AGACAGCAGC AAGGTGTGTA 
TGTCCCTTTT GTCAGAGGGA ACTGTATGAA GACAGCTTGC TGGATCATTG TATTACTCAT 
CACAGATCGG AACGGAGGCC TGTGTTCTGT CCACTTTGCC GTTTAATACC CGATGAGAAT 
CCAAGCAGCT TCAGTGGCAG TTTAATAAGA CATCTGCAAG TTAGTCACAC TTTGTTTTAT 
GATGATTTCA TAGATAACAA TACGAAGATC CACCTGTCTT GCTGCTGCCC AAGACCACAC 
TTCCATCCAC AAGTTCCCCA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RNF125 ( XM_011526047.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011524349.1 Homo sapiens ring finger protein 125 (RNF125), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu68813
Clone ID Related Accession (Same CDS sequence)	XM_011526047.3 , XM_011526047.2
Accession Version	XM_011526047.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 576bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase RNF125 isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000018.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011526047.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCTCCG TGCTGAGCAC CGACAGCGGC AAATCGGCGC CCGCCTCTGC CACCGCGCGG 
GCCCTGGAGC GCAGGAGGGA CCCGGAGTTG CCCGTCACGT CCTTCGACTG CGCCGTGTGC 
CTTGAGGTGT TACACCAGCC TGTCCGGACC CGCTGTGGCC ACGTATTCTG CCGTTCCTGT 
ATTGCTACCA GTCTAAAGAA CAACAAGTGG ACCTGTCCTT ATTGCCGGGC ATATCTTCCT 
TCAGAAGGAG TTCCAGCAAC TGATGTAGCC AAAAGAATGA AATCAGAGTA TAAGAACTGC 
GCTGAGTGTG ACACCCTGGT TTGCCTCAGT GAAATGAGGG CACATATTCG GACTTGTCAG 
AAGTACATAG ATAAGTATGG ACCACTACAA GAACTTGAGG AGACAGCAGC AAGGTGTGTA 
TGTCCCTTTT GTCAGAGGGA ACTGTATGAA GACAGCTTGC TGGATCATTG TATTACTCAT 
CACAGATCGG AACGGAGGCC TGTGGATAAC AATACGAAGA TCCACCTGTC TTGCTGCTGC 
CCAAGACCAC ACTTCCATCC ACAAGTTCCC CAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011524349.1
CDS	280..855
Translation	MGSVLSTDSGKSAPASATARALERRRDPELPVTSFDCAVCLEVLHQPVRTRCGHVFCRSCIATSLKNNKWTCPYCRAYLPSEGVPATDVAKRMKSEYKNCAECDTLVCLSEMRAHIRTCQKYIDKYGPLQELEETAARCVCPFCQRELYEDSLLDHCITHHRSERRPVDNNTKIHLSCCCPRPHFHPQVPQ

Target ORF information:

RefSeq Version	XM_011526047.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ring finger protein 125 (RNF125), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011526047.3

ORF Insert Sequence:

ATGGGCTCCG TGCTGAGCAC CGACAGCGGC AAATCGGCGC CCGCCTCTGC CACCGCGCGG 
GCCCTGGAGC GCAGGAGGGA CCCGGAGTTG CCCGTCACGT CCTTCGACTG CGCCGTGTGC 
CTTGAGGTGT TACACCAGCC TGTCCGGACC CGCTGTGGCC ACGTATTCTG CCGTTCCTGT 
ATTGCTACCA GTCTAAAGAA CAACAAGTGG ACCTGTCCTT ATTGCCGGGC ATATCTTCCT 
TCAGAAGGAG TTCCAGCAAC TGATGTAGCC AAAAGAATGA AATCAGAGTA TAAGAACTGC 
GCTGAGTGTG ACACCCTGGT TTGCCTCAGT GAAATGAGGG CACATATTCG GACTTGTCAG 
AAGTACATAG ATAAGTATGG ACCACTACAA GAACTTGAGG AGACAGCAGC AAGGTGTGTA 
TGTCCCTTTT GTCAGAGGGA ACTGTATGAA GACAGCTTGC TGGATCATTG TATTACTCAT 
CACAGATCGG AACGGAGGCC TGTGGATAAC AATACGAAGA TCCACCTGTC TTGCTGCTGC 
CCAAGACCAC ACTTCCATCC ACAAGTTCCC CAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RNF125 ( XM_011526047.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011524349.1 Homo sapiens ring finger protein 125, E3 ubiquitin protein ligase (RNF125), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu68813
Clone ID Related Accession (Same CDS sequence)	XM_011526047.3 , XM_011526047.2
Accession Version	XM_011526047.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 576bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase RNF125 isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000018.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011526047.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCTCCG TGCTGAGCAC CGACAGCGGC AAATCGGCGC CCGCCTCTGC CACCGCGCGG 
GCCCTGGAGC GCAGGAGGGA CCCGGAGTTG CCCGTCACGT CCTTCGACTG CGCCGTGTGC 
CTTGAGGTGT TACACCAGCC TGTCCGGACC CGCTGTGGCC ACGTATTCTG CCGTTCCTGT 
ATTGCTACCA GTCTAAAGAA CAACAAGTGG ACCTGTCCTT ATTGCCGGGC ATATCTTCCT 
TCAGAAGGAG TTCCAGCAAC TGATGTAGCC AAAAGAATGA AATCAGAGTA TAAGAACTGC 
GCTGAGTGTG ACACCCTGGT TTGCCTCAGT GAAATGAGGG CACATATTCG GACTTGTCAG 
AAGTACATAG ATAAGTATGG ACCACTACAA GAACTTGAGG AGACAGCAGC AAGGTGTGTA 
TGTCCCTTTT GTCAGAGGGA ACTGTATGAA GACAGCTTGC TGGATCATTG TATTACTCAT 
CACAGATCGG AACGGAGGCC TGTGGATAAC AATACGAAGA TCCACCTGTC TTGCTGCTGC 
CCAAGACCAC ACTTCCATCC ACAAGTTCCC CAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011524349.1
CDS	662..1237
Translation	MGSVLSTDSGKSAPASATARALERRRDPELPVTSFDCAVCLEVLHQPVRTRCGHVFCRSCIATSLKNNKWTCPYCRAYLPSEGVPATDVAKRMKSEYKNCAECDTLVCLSEMRAHIRTCQKYIDKYGPLQELEETAARCVCPFCQRELYEDSLLDHCITHHRSERRPVDNNTKIHLSCCCPRPHFHPQVPQ

Target ORF information:

RefSeq Version	XM_011526047.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ring finger protein 125, E3 ubiquitin protein ligase (RNF125), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011526047.2

ORF Insert Sequence:

ATGGGCTCCG TGCTGAGCAC CGACAGCGGC AAATCGGCGC CCGCCTCTGC CACCGCGCGG 
GCCCTGGAGC GCAGGAGGGA CCCGGAGTTG CCCGTCACGT CCTTCGACTG CGCCGTGTGC 
CTTGAGGTGT TACACCAGCC TGTCCGGACC CGCTGTGGCC ACGTATTCTG CCGTTCCTGT 
ATTGCTACCA GTCTAAAGAA CAACAAGTGG ACCTGTCCTT ATTGCCGGGC ATATCTTCCT 
TCAGAAGGAG TTCCAGCAAC TGATGTAGCC AAAAGAATGA AATCAGAGTA TAAGAACTGC 
GCTGAGTGTG ACACCCTGGT TTGCCTCAGT GAAATGAGGG CACATATTCG GACTTGTCAG 
AAGTACATAG ATAAGTATGG ACCACTACAA GAACTTGAGG AGACAGCAGC AAGGTGTGTA 
TGTCCCTTTT GTCAGAGGGA ACTGTATGAA GACAGCTTGC TGGATCATTG TATTACTCAT 
CACAGATCGG AACGGAGGCC TGTGGATAAC AATACGAAGA TCCACCTGTC TTGCTGCTGC 
CCAAGACCAC ACTTCCATCC ACAAGTTCCC CAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

E3 Ubiquitin Ligase RNF125 Activates Interleukin-36 Receptor Signaling and Contributes to Its Turnover.
Journal of innate immunity(2017 Nov)
Saha SS,Caviness G,Yi G,Raymond EL,Mbow ML,Kao CC

Ring finger protein 125, as a potential highly aggressive and unfavorable prognostic biomarker, promotes the invasion and metastasis of human gallbladder cancers via activating the TGF- ?1-SMAD3-ID1 signaling pathway.
Oncotarget8(30)49897-49914(2017 Jul)
Liu ZY,Cao J,Zhang JT,Xu GL,Li XP,Wang FT,Ansari KH,Mohamed H,Fan YZ

The Ubiquitin Ligase RNF125 Targets Innate Immune Adaptor Protein TRIM14 for Ubiquitination and Degradation.
Journal of immunology (Baltimore, Md. : 1950)198(12)4652-4658(2017 Jun)
Jia X,Zhou H,Wu C,Wu Q,Ma S,Wei C,Cao Y,Song J,Zhong H,Zhou Z,Wang J

A C2HC zinc finger is essential for the RING-E2 interaction of the ubiquitin ligase RNF125.
Scientific reports629232(2016 Jul)
Bijlmakers MJ,Teixeira JM,Boer R,Mayzel M,Puig-S?rries P,Karlsson G,Coll M,Pons M,Crosas B

A non-canonical role of the p97 complex in RIG-I antiviral signaling.
The EMBO journal34(23)2903-20(2015 Dec)
Hao Q,Jiao S,Shi Z,Li C,Meng X,Zhang Z,Wang Y,Song X,Wang W,Zhang R,Zhao Y,Wong CC,Zhou Z

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RNF125 cDNA ORF clone, Homo sapiens(human)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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