TRMT10C cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TRMT10C
Entrez Gene ID	54931
Full Name	tRNA methyltransferase 10C, mitochondrial RNase P subunit
Synonyms	COXPD30,HNYA,MRPP1,RG9MTD1
General protein information	Preferred Names tRNA methyltransferase 10C, mitochondrial RNase P subunit Names tRNA methyltransferase 10 homolog C HBV pre-S2 trans-regulated protein 2 RNA (guanine-9-) methyltransferase domain containing 1 mRNA methyladenosine-N(1)-methyltransferase mitochondrial RNase P subunit 1 mitochondrial ribonuclease P protein 1 renal carcinoma antigen NY-REN-49 tRNA (adenine(9)-N(1))-methyltransferase tRNA (guanine(9)-N(1))-methyltransferase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q12.3
Summary	This gene encodes the precursor of a subunit of the mitochondrial ribonuclease P, which is involved in 5' processing of mitochondrial tRNAs. The encoded protein may confer RNA-binding capacity to mitochondrial ribonuclease P and may be essential for transcript processing, RNA modification, translation and mitochondrial respiration. [provided by RefSeq, Nov 2012].
Disorder MIM:	615423
Disorder Html:	Combined oxidative phosphorylation deficiency 30, 616974 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_017819.3	NP_060289.2	tRNA methyltransferase 10 homolog C precursor
NM_017819.4	NP_060289.2	tRNA methyltransferase 10 homolog C precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	TRMT10C	NP_060289.2
	LOC702107	XP_001090390.1
Xenopus tropicalis (tropical clawed frog)	trmt10c	NP_001096307.1
Bos taurus (cattle)	TRMT10C	NP_001039788.1
Mus musculus (house mouse)	Trmt10c	NP_083368.1
Caenorhabditis elegans (roundworm)	F46F11.10	NP_491647.3
Canis lupus familiaris (dog)	TRMT10C	XP_535722.3
Gallus gallus (chicken)	TRMT10C	XP_001232374.3
Pan troglodytes (chimpanzee)	RG9MTD1	NP_001230873.1
Rattus norvegicus (Norway rat)	Trmt10c	NP_001008338.1
Danio rerio (zebrafish)	trmt10c	NP_001007333.2
Drosophila melanogaster (fruit fly)	CG5190	NP_611335.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007211	XP_308574.4

Gene Ontology
Bibliography

Related articles in PubMed

The MRPP1/MRPP2 complex is a tRNA-maturation platform in human mitochondria.
Reinhard L, Sridhara S, H?llberg BM
Nucleic acids research45(21)12469-12480(2017 Dec)

The m1A landscape on cytosolic and mitochondrial mRNA at single-base resolution.
Safra M, Sas-Chen A, Nir R, Winkler R, Nachshon A, Bar-Yaacov D, Erlacher M, Rossmanith W, Stern-Ginossar N, Schwartz S
Nature551(7679)251-255(2017 Nov)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Recessive Mutations in TRMT10C Cause Defects in Mitochondrial RNA Processing and Multiple Respiratory Chain Deficiencies.
Metodiev MD, Thompson K, Alston CL, Morris AAM, He L, Assouline Z, Rio M, Bahi-Buisson N, Pyle A, Griffin H, Siira S, Filipovska A, Munnich A, Chinnery PF, McFarland R, R?tig A, Taylor RW
American journal of human genetics98(5)993-1000(2016 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

in addition to being an essential component of the RNase P reaction, MRPP1/2 serves as a processing platform for several down-stream tRNA maturation steps in human mitochondria.
Title: The MRPP1/MRPP2 complex is a tRNA-maturation platform in human mitochondria.

identifying mutations in TRMT10C as a cause of mitochondrial disease and highlighting the importance of RNA processing for correct mitochondrial function
Title: Recessive Mutations in TRMT10C Cause Defects in Mitochondrial RNA Processing and Multiple Respiratory Chain Deficiencies.

Inhibition of mitochondrial RNase P by beta-amyloid is an unspecific effect and is not mediated by beta-amyloid interaction with SDR5C1.
Title: The amyloid-?-SDR5C1(ABAD) interaction does not mediate a specific inhibition of mitochondrial RNase P.

We also identify the 5' and 3' transcript ends of the three lncRNAs and show that mitochondrial RNase P protein 1 (MRPP1) is important for the processing of these transcripts.
Title: Long noncoding RNAs are generated from the mitochondrial genome and regulated by nuclear-encoded proteins.

MRPP1 is essential for transcript processing, RNA modification, translation and mitochondrial respiration.
Title: RNA processing in human mitochondria.

The following TRMT10C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TRMT10C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09980	NM_017819.4 Latest version!	Homo sapiens tRNA methyltransferase 10C, mitochondrial RNase P subunit (TRMT10C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu09980	NM_017819.3	Homo sapiens tRNA methyltransferase 10C, mitochondrial RNase P subunit (TRMT10C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TRMT10C ( NM_017819.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_060289.2 Homo sapiens tRNA methyltransferase 10C, mitochondrial RNase P subunit (TRMT10C), mRNA.

Price & Availability↑

CloneID	OHu09980
Clone ID Related Accession (Same CDS sequence)	NM_017819.3 , NM_017819.4
Accession Version	NM_017819.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1212bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-31
Organism	Homo sapiens(human)
Product	tRNA methyltransferase 10 homolog C precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM752893.1, BC035967.1 and BU619586.1. This sequence is a reference standard in the RefSeqGene project. On Nov 20, 2012 this sequence version replaced NM_017819.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.129865.1, SRR1803615.158824.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCTT TCCTCAAAAT GAGTGTTAGT GTCAATTTCT TCAGACCTTT CACCAGGTTT 
TTGGTGCCAT TTACCCTTCA TAGGAAGAGA AATAACTTAA CAATTTTGCA GAGATACATG 
TCTTCCAAAA TACCAGCTGT TACTTATCCT AAAAATGAGA GTACACCCCC TTCTGAAGAG 
CTAGAGTTGG ATAAGTGGAA AACTACCATG AAATCTAGTG TGCAAGAAGA ATGTGTTTCA 
ACAATCTCAA GCAGTAAGGA TGAAGATCCT CTAGCTGCCA CCAGAGAGTT CATTGAGATG 
TGGAGATTGC TTGGCAGAGA AGTACCAGAA CACATCACTG AAGAAGAGCT CAAAACCCTT 
ATGGAATGTG TTTCTAACAC AGCAAAAAAA AAATATTTAA AATATTTATA TACGAAGGAA 
AAAGTGAAAA AAGCTAGGCA AATAAAAAAG GAAATGAAAG CAGCAGCAAG GGAAGAAGCA 
AAAAATATCA AGCTGCTAGA AACCACTGAG GAAGATAAAC AGAAAAACTT TCTATTTTTA 
CGACTTTGGG ATAGGAATAT GGACATAGCA ATGGGCTGGA AGGGTGCCCA GGCCATGCAG 
TTTGGACAAC CTTTGGTTTT TGACATGGCT TACGAAAATT ATATGAAACG AAAAGAATTG 
CAGAATACTG TTTCCCAGCT TTTAGAAAGT GAAGGATGGA ACAGAAGAAA TGTTGATCCT 
TTCCATATTT ATTTCTGCAA TCTAAAAATA GATGGTGCTT TGCACAGAGA GTTAGTTAAA 
CGGTATCAAG AAAAATGGGA CAAATTGCTT TTAACATCAA CAGAAAAGTC TCATGTAGAT 
TTATTTCCAA AGGACAGTAT TATCTATTTA ACTGCAGATT CTCCCAATGT TATGACTACT 
TTCAGGCATG ACAAAGTTTA TGTAATTGGG TCTTTTGTTG ATAAGAGTAT GCAGCCAGGC 
ACATCCCTAG CCAAGGCAAA ACGGCTGAAC CTGGCAACTG AATGCCTTCC ATTAGATAAA 
TATTTACAAT GGGAAATTGG TAACAAAAAT CTCACCTTAG ATCAAATGAT ACGTATTTTG 
TTATGTCTGA AAAACAATGG TAATTGGCAA GAGGCTCTGC AATTCGTTCC CAAGAGAAAA 
CATACTGGTT TTCTGGAGAT TTCTCAGCAT TCTCAAGAGT TTATCAACAG ACTAAAGAAG 
GCAAAGACTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060289.2
CDS	181..1392
Translation	MAAFLKMSVSVNFFRPFTRFLVPFTLHRKRNNLTILQRYMSSKIPAVTYPKNESTPPSEELELDKWKTTMKSSVQEECVSTISSSKDEDPLAATREFIEMWRLLGREVPEHITEEELKTLMECVSNTAKKKYLKYLYTKEKVKKARQIKKEMKAAAREEAKNIKLLETTEEDKQKNFLFLRLWDRNMDIAMGWKGAQAMQFGQPLVFDMAYENYMKRKELQNTVSQLLESEGWNRRNVDPFHIYFCNLKIDGALHRELVKRYQEKWDKLLLTSTEKSHVDLFPKDSIIYLTADSPNVMTTFRHDKVYVIGSFVDKSMQPGTSLAKAKRLNLATECLPLDKYLQWEIGNKNLTLDQMIRILLCLKNNGNWQEALQFVPKRKHTGFLEISQHSQEFINRLKKAKT

Target ORF information:

RefSeq Version	NM_017819.3
Organism	Homo sapiens(human)
Definition	Homo sapiens tRNA methyltransferase 10C, mitochondrial RNase P subunit (TRMT10C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017819.3

ORF Insert Sequence:

ATGGCTGCTT TCCTCAAAAT GAGTGTTAGT GTCAATTTCT TCAGACCTTT CACCAGGTTT 
TTGGTGCCAT TTACCCTTCA TAGGAAGAGA AATAACTTAA CAATTTTGCA GAGATACATG 
TCTTCCAAAA TACCAGCTGT TACTTATCCT AAAAATGAGA GTACACCCCC TTCTGAAGAG 
CTAGAGTTGG ATAAGTGGAA AACTACCATG AAATCTAGTG TGCAAGAAGA ATGTGTTTCA 
ACAATCTCAA GCAGTAAGGA TGAAGATCCT CTAGCTGCCA CCAGAGAGTT CATTGAGATG 
TGGAGATTGC TTGGCAGAGA AGTACCAGAA CACATCACTG AAGAAGAGCT CAAAACCCTT 
ATGGAATGTG TTTCTAACAC AGCAAAAAAA AAATATTTAA AATATTTATA TACGAAGGAA 
AAAGTGAAAA AAGCTAGGCA AATAAAAAAG GAAATGAAAG CAGCAGCAAG GGAAGAAGCA 
AAAAATATCA AGCTGCTAGA AACCACTGAG GAAGATAAAC AGAAAAACTT TCTATTTTTA 
CGACTTTGGG ATAGGAATAT GGACATAGCA ATGGGCTGGA AGGGTGCCCA GGCCATGCAG 
TTTGGACAAC CTTTGGTTTT TGACATGGCT TACGAAAATT ATATGAAACG AAAAGAATTG 
CAGAATACTG TTTCCCAGCT TTTAGAAAGT GAAGGATGGA ACAGAAGAAA TGTTGATCCT 
TTCCATATTT ATTTCTGCAA TCTAAAAATA GATGGTGCTT TGCACAGAGA GTTAGTTAAA 
CGGTATCAAG AAAAATGGGA CAAATTGCTT TTAACATCAA CAGAAAAGTC TCATGTAGAT 
TTATTTCCAA AGGACAGTAT TATCTATTTA ACTGCAGATT CTCCCAATGT TATGACTACT 
TTCAGGCATG ACAAAGTTTA TGTAATTGGG TCTTTTGTTG ATAAGAGTAT GCAGCCAGGC 
ACATCCCTAG CCAAGGCAAA ACGGCTGAAC CTGGCAACTG AATGCCTTCC ATTAGATAAA 
TATTTACAAT GGGAAATTGG TAACAAAAAT CTCACCTTAG ATCAAATGAT ACGTATTTTG 
TTATGTCTGA AAAACAATGG TAATTGGCAA GAGGCTCTGC AATTCGTTCC CAAGAGAAAA 
CATACTGGTT TTCTGGAGAT TTCTCAGCAT TCTCAAGAGT TTATCAACAG ACTAAAGAAG 
GCAAAGACTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TRMT10C ( NM_017819.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_060289.2 Homo sapiens tRNA methyltransferase 10C, mitochondrial RNase P subunit (TRMT10C), mRNA.

Price & Availability↑

CloneID	OHu09980
Clone ID Related Accession (Same CDS sequence)	NM_017819.3 , NM_017819.4
Accession Version	NM_017819.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1212bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	tRNA methyltransferase 10 homolog C precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC035967.1 and BU619586.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_017819.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.819130.1, SRR1660807.129865.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000309922.7/ ENSP00000312356.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTGCTT TCCTCAAAAT GAGTGTTAGT GTCAATTTCT TCAGACCTTT CACCAGGTTT 
TTGGTGCCAT TTACCCTTCA TAGGAAGAGA AATAACTTAA CAATTTTGCA GAGATACATG 
TCTTCCAAAA TACCAGCTGT TACTTATCCT AAAAATGAGA GTACACCCCC TTCTGAAGAG 
CTAGAGTTGG ATAAGTGGAA AACTACCATG AAATCTAGTG TGCAAGAAGA ATGTGTTTCA 
ACAATCTCAA GCAGTAAGGA TGAAGATCCT CTAGCTGCCA CCAGAGAGTT CATTGAGATG 
TGGAGATTGC TTGGCAGAGA AGTACCAGAA CACATCACTG AAGAAGAGCT CAAAACCCTT 
ATGGAATGTG TTTCTAACAC AGCAAAAAAA AAATATTTAA AATATTTATA TACGAAGGAA 
AAAGTGAAAA AAGCTAGGCA AATAAAAAAG GAAATGAAAG CAGCAGCAAG GGAAGAAGCA 
AAAAATATCA AGCTGCTAGA AACCACTGAG GAAGATAAAC AGAAAAACTT TCTATTTTTA 
CGACTTTGGG ATAGGAATAT GGACATAGCA ATGGGCTGGA AGGGTGCCCA GGCCATGCAG 
TTTGGACAAC CTTTGGTTTT TGACATGGCT TACGAAAATT ATATGAAACG AAAAGAATTG 
CAGAATACTG TTTCCCAGCT TTTAGAAAGT GAAGGATGGA ACAGAAGAAA TGTTGATCCT 
TTCCATATTT ATTTCTGCAA TCTAAAAATA GATGGTGCTT TGCACAGAGA GTTAGTTAAA 
CGGTATCAAG AAAAATGGGA CAAATTGCTT TTAACATCAA CAGAAAAGTC TCATGTAGAT 
TTATTTCCAA AGGACAGTAT TATCTATTTA ACTGCAGATT CTCCCAATGT TATGACTACT 
TTCAGGCATG ACAAAGTTTA TGTAATTGGG TCTTTTGTTG ATAAGAGTAT GCAGCCAGGC 
ACATCCCTAG CCAAGGCAAA ACGGCTGAAC CTGGCAACTG AATGCCTTCC ATTAGATAAA 
TATTTACAAT GGGAAATTGG TAACAAAAAT CTCACCTTAG ATCAAATGAT ACGTATTTTG 
TTATGTCTGA AAAACAATGG TAATTGGCAA GAGGCTCTGC AATTCGTTCC CAAGAGAAAA 
CATACTGGTT TTCTGGAGAT TTCTCAGCAT TCTCAAGAGT TTATCAACAG ACTAAAGAAG 
GCAAAGACTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060289.2
CDS	149..1360
Translation	MAAFLKMSVSVNFFRPFTRFLVPFTLHRKRNNLTILQRYMSSKIPAVTYPKNESTPPSEELELDKWKTTMKSSVQEECVSTISSSKDEDPLAATREFIEMWRLLGREVPEHITEEELKTLMECVSNTAKKKYLKYLYTKEKVKKARQIKKEMKAAAREEAKNIKLLETTEEDKQKNFLFLRLWDRNMDIAMGWKGAQAMQFGQPLVFDMAYENYMKRKELQNTVSQLLESEGWNRRNVDPFHIYFCNLKIDGALHRELVKRYQEKWDKLLLTSTEKSHVDLFPKDSIIYLTADSPNVMTTFRHDKVYVIGSFVDKSMQPGTSLAKAKRLNLATECLPLDKYLQWEIGNKNLTLDQMIRILLCLKNNGNWQEALQFVPKRKHTGFLEISQHSQEFINRLKKAKT

Target ORF information:

RefSeq Version	NM_017819.4
Organism	Homo sapiens(human)
Definition	Homo sapiens tRNA methyltransferase 10C, mitochondrial RNase P subunit (TRMT10C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017819.4

ORF Insert Sequence:

ATGGCTGCTT TCCTCAAAAT GAGTGTTAGT GTCAATTTCT TCAGACCTTT CACCAGGTTT 
TTGGTGCCAT TTACCCTTCA TAGGAAGAGA AATAACTTAA CAATTTTGCA GAGATACATG 
TCTTCCAAAA TACCAGCTGT TACTTATCCT AAAAATGAGA GTACACCCCC TTCTGAAGAG 
CTAGAGTTGG ATAAGTGGAA AACTACCATG AAATCTAGTG TGCAAGAAGA ATGTGTTTCA 
ACAATCTCAA GCAGTAAGGA TGAAGATCCT CTAGCTGCCA CCAGAGAGTT CATTGAGATG 
TGGAGATTGC TTGGCAGAGA AGTACCAGAA CACATCACTG AAGAAGAGCT CAAAACCCTT 
ATGGAATGTG TTTCTAACAC AGCAAAAAAA AAATATTTAA AATATTTATA TACGAAGGAA 
AAAGTGAAAA AAGCTAGGCA AATAAAAAAG GAAATGAAAG CAGCAGCAAG GGAAGAAGCA 
AAAAATATCA AGCTGCTAGA AACCACTGAG GAAGATAAAC AGAAAAACTT TCTATTTTTA 
CGACTTTGGG ATAGGAATAT GGACATAGCA ATGGGCTGGA AGGGTGCCCA GGCCATGCAG 
TTTGGACAAC CTTTGGTTTT TGACATGGCT TACGAAAATT ATATGAAACG AAAAGAATTG 
CAGAATACTG TTTCCCAGCT TTTAGAAAGT GAAGGATGGA ACAGAAGAAA TGTTGATCCT 
TTCCATATTT ATTTCTGCAA TCTAAAAATA GATGGTGCTT TGCACAGAGA GTTAGTTAAA 
CGGTATCAAG AAAAATGGGA CAAATTGCTT TTAACATCAA CAGAAAAGTC TCATGTAGAT 
TTATTTCCAA AGGACAGTAT TATCTATTTA ACTGCAGATT CTCCCAATGT TATGACTACT 
TTCAGGCATG ACAAAGTTTA TGTAATTGGG TCTTTTGTTG ATAAGAGTAT GCAGCCAGGC 
ACATCCCTAG CCAAGGCAAA ACGGCTGAAC CTGGCAACTG AATGCCTTCC ATTAGATAAA 
TATTTACAAT GGGAAATTGG TAACAAAAAT CTCACCTTAG ATCAAATGAT ACGTATTTTG 
TTATGTCTGA AAAACAATGG TAATTGGCAA GAGGCTCTGC AATTCGTTCC CAAGAGAAAA 
CATACTGGTT TTCTGGAGAT TTCTCAGCAT TCTCAAGAGT TTATCAACAG ACTAAAGAAG 
GCAAAGACTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The MRPP1/MRPP2 complex is a tRNA-maturation platform in human mitochondria.
Nucleic acids research45(21)12469-12480(2017 Dec)
Reinhard L,Sridhara S,H?llberg BM

The m1A landscape on cytosolic and mitochondrial mRNA at single-base resolution.
Nature551(7679)251-255(2017 Nov)
Safra M,Sas-Chen A,Nir R,Winkler R,Nachshon A,Bar-Yaacov D,Erlacher M,Rossmanith W,Stern-Ginossar N,Schwartz S

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Recessive Mutations in TRMT10C Cause Defects in Mitochondrial RNA Processing and Multiple Respiratory Chain Deficiencies.
American journal of human genetics98(5)993-1000(2016 May)
Metodiev MD,Thompson K,Alston CL,Morris AAM,He L,Assouline Z,Rio M,Bahi-Buisson N,Pyle A,Griffin H,Siira S,Filipovska A,Munnich A,Chinnery PF,McFarland R,R?tig A,Taylor RW

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TRMT10C cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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