RPP25 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RPP25
Entrez Gene ID	54913
Full Name	ribonuclease P and MRP subunit p25
General protein information	Preferred Names ribonuclease P and MRP subunit p25 Names ribonuclease P protein subunit p25 RNase P protein subunit p25 ribonuclease P 25kDa subunit ribonuclease P/MRP 25kDa subunit ribonuclease P/MRP subunit p25
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q24.2

mRNA and Protein(s)

mRNA	Protein	Name
NM_017793.2	NP_060263.2	ribonuclease P protein subunit p25
NM_017793.3	NP_060263.2	ribonuclease P protein subunit p25

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	RPP25	XP_510676.1
Bos taurus (cattle)	RPP25	XP_005222072.1
Canis lupus familiaris (dog)	RPP25	XP_005638690.1
Xenopus tropicalis (tropical clawed frog)	rpp25	XP_004916048.1
Homo sapiens (human)	RPP25	NP_060263.2
Mus musculus (house mouse)	Rpp25	NP_598743.1
Rattus norvegicus (Norway rat)	Rpp25	NP_001012124.1
Danio rerio (zebrafish)	LOC101883990	XP_005163195.1
	RPP25	XP_001101885.1
Gallus gallus (chicken)	RPP25	XP_004943736.1
Danio rerio (zebrafish)	LOC101885168	XP_005173657.1
Danio rerio (zebrafish)	rpp25	XP_005163196.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Rpp25 is a major target of autoantibodies to the Th/To complex as measured by a novel chemiluminescent assay.
Mahler M, Gascon C, Patel S, Ceribelli A, Fritzler MJ, Swart A, Chan EK, Satoh M
Arthritis research & therapy15(2)R50(2013 Apr)

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Rpp25 is a major target of autoantibodies to the Th/To autoantigen complex
Title: Rpp25 is a major target of autoantibodies to the Th/To complex as measured by a novel chemiluminescent assay.

Taken together, these findings suggest a potential role for the RPP25 gene transcript in the neurobiology of developmental brain disorders.
Title: RPP25 is developmentally regulated in prefrontal cortex and expressed at decreased levels in autism spectrum disorder.

analyses of interactions with deletion mutant proteins indicate that the Alba-type core domain of both Rpp20 and Rpp25 contains most of the determinants for mutual association and P3 RNA recognition.
Title: Heterodimerization of the human RNase P/MRP subunits Rpp20 and Rpp25 is a prerequisite for interaction with the P3 arm of RNase MRP RNA.

The following RPP25 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RPP25 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu11141	NM_017793.3 Latest version!	Homo sapiens ribonuclease P and MRP subunit p25 (RPP25), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu11141	NM_017793.2	Homo sapiens ribonuclease P and MRP subunit p25 (RPP25), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RPP25 ( NM_017793.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_060263.2 Homo sapiens ribonuclease P and MRP subunit p25 (RPP25), mRNA.

Price & Availability↑

CloneID	OHu11141
Clone ID Related Accession (Same CDS sequence)	NM_017793.2 , NM_017793.3
Accession Version	NM_017793.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 600bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-20
Organism	Homo sapiens(human)
Product	ribonuclease P protein subunit p25
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA041068.1, AC015720.20 and BE254727.1. On Apr 25, 2006 this sequence version replaced NM_017793.1. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGAGAACT TCCGTAAGGT GCGCTCCGAA GAGGCGCCAG CGGGGTGCGG GGCCGAGGGA 
GGCGGCCCGG GCTCCGGCCC CTTCGCAGAC CTGGCGCCGG GCGCGGTGCA CATGCGGGTC 
AAGGAAGGCA GCAAGATCCG GAACCTGATG GCCTTCGCCA CCGCCAGCAT GGCGCAGCCA 
GCCACGCGCG CCATCGTCTT CAGCGGCTGC GGCCGGGCCA CCACCAAAAC CGTCACGTGC 
GCCGAGATCC TCAAGCGCCG CCTGGCGGGC CTGCACCAGG TCACGCGGCT GCGCTACCGG 
AGCGTACGCG AGGTGTGGCA GAGCCTCCCG CCTGGGCCCA CGCAGGGTCA GACGCCTGGC 
GAGCCGGCCG CTAGTCTCAG CGTACTTAAG AACGTGCCCG GCCTCGCCAT CCTACTTTCC 
AAGGACGCGC TGGATCCGCG ACAGCCCGGC TACCAGCCCC CGAATCCCCA TCCTGGTCCC 
TCGTCCCCGC CAGCCGCGCC AGCGTCCAAG AGGAGCCTAG GGGAACCCGC AGCTGGAGAA 
GGCTCCGCGA AGCGATCGCA ACCCGAGCCA GGGGTTGCGG ACGAGGATCA GACGGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060263.2
CDS	852..1451
Translation	MENFRKVRSEEAPAGCGAEGGGPGSGPFADLAPGAVHMRVKEGSKIRNLMAFATASMAQPATRAIVFSGCGRATTKTVTCAEILKRRLAGLHQVTRLRYRSVREVWQSLPPGPTQGQTPGEPAASLSVLKNVPGLAILLSKDALDPRQPGYQPPNPHPGPSSPPAAPASKRSLGEPAAGEGSAKRSQPEPGVADEDQTA

Target ORF information:

RefSeq Version	NM_017793.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ribonuclease P and MRP subunit p25 (RPP25), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017793.2

ORF Insert Sequence:

ATGGAGAACT TCCGTAAGGT GCGCTCCGAA GAGGCGCCAG CGGGGTGCGG GGCCGAGGGA 
GGCGGCCCGG GCTCCGGCCC CTTCGCAGAC CTGGCGCCGG GCGCGGTGCA CATGCGGGTC 
AAGGAAGGCA GCAAGATCCG GAACCTGATG GCCTTCGCCA CCGCCAGCAT GGCGCAGCCA 
GCCACGCGCG CCATCGTCTT CAGCGGCTGC GGCCGGGCCA CCACCAAAAC CGTCACGTGC 
GCCGAGATCC TCAAGCGCCG CCTGGCGGGC CTGCACCAGG TCACGCGGCT GCGCTACCGG 
AGCGTACGCG AGGTGTGGCA GAGCCTCCCG CCTGGGCCCA CGCAGGGTCA GACGCCTGGC 
GAGCCGGCCG CTAGTCTCAG CGTACTTAAG AACGTGCCCG GCCTCGCCAT CCTACTTTCC 
AAGGACGCGC TGGATCCGCG ACAGCCCGGC TACCAGCCCC CGAATCCCCA TCCTGGTCCC 
TCGTCCCCGC CAGCCGCGCC AGCGTCCAAG AGGAGCCTAG GGGAACCCGC AGCTGGAGAA 
GGCTCCGCGA AGCGATCGCA ACCCGAGCCA GGGGTTGCGG ACGAGGATCA GACGGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RPP25 ( NM_017793.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_060263.2 Homo sapiens ribonuclease P and MRP subunit p25 (RPP25), mRNA.

Price & Availability↑

CloneID	OHu11141
Clone ID Related Accession (Same CDS sequence)	NM_017793.2 , NM_017793.3
Accession Version	NM_017793.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 600bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	ribonuclease P protein subunit p25
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC015720.20. On Aug 6, 2019 this sequence version replaced NM_017793.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: SRR1660805.71097.1, SRR6380199.117351.9 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGAACT TCCGTAAGGT GCGCTCCGAA GAGGCGCCAG CGGGGTGCGG GGCCGAGGGA 
GGCGGCCCGG GCTCCGGCCC CTTCGCAGAC CTGGCGCCGG GCGCGGTGCA CATGCGGGTC 
AAGGAAGGCA GCAAGATCCG GAACCTGATG GCCTTCGCCA CCGCCAGCAT GGCGCAGCCA 
GCCACGCGCG CCATCGTCTT CAGCGGCTGC GGCCGGGCCA CCACCAAAAC CGTCACGTGC 
GCCGAGATCC TCAAGCGCCG CCTGGCGGGC CTGCACCAGG TCACGCGGCT GCGCTACCGG 
AGCGTACGCG AGGTGTGGCA GAGCCTCCCG CCTGGGCCCA CGCAGGGTCA GACGCCTGGC 
GAGCCGGCCG CTAGTCTCAG CGTACTTAAG AACGTGCCCG GCCTCGCCAT CCTACTTTCC 
AAGGACGCGC TGGATCCGCG ACAGCCCGGC TACCAGCCCC CGAATCCCCA TCCTGGTCCC 
TCGTCCCCGC CAGCCGCGCC AGCGTCCAAG AGGAGCCTAG GGGAACCCGC AGCTGGAGAA 
GGCTCCGCGA AGCGATCGCA ACCCGAGCCA GGGGTTGCGG ACGAGGATCA GACGGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060263.2
CDS	190..789
Translation	MENFRKVRSEEAPAGCGAEGGGPGSGPFADLAPGAVHMRVKEGSKIRNLMAFATASMAQPATRAIVFSGCGRATTKTVTCAEILKRRLAGLHQVTRLRYRSVREVWQSLPPGPTQGQTPGEPAASLSVLKNVPGLAILLSKDALDPRQPGYQPPNPHPGPSSPPAAPASKRSLGEPAAGEGSAKRSQPEPGVADEDQTA

Target ORF information:

RefSeq Version	NM_017793.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ribonuclease P and MRP subunit p25 (RPP25), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017793.3

ORF Insert Sequence:

ATGGAGAACT TCCGTAAGGT GCGCTCCGAA GAGGCGCCAG CGGGGTGCGG GGCCGAGGGA 
GGCGGCCCGG GCTCCGGCCC CTTCGCAGAC CTGGCGCCGG GCGCGGTGCA CATGCGGGTC 
AAGGAAGGCA GCAAGATCCG GAACCTGATG GCCTTCGCCA CCGCCAGCAT GGCGCAGCCA 
GCCACGCGCG CCATCGTCTT CAGCGGCTGC GGCCGGGCCA CCACCAAAAC CGTCACGTGC 
GCCGAGATCC TCAAGCGCCG CCTGGCGGGC CTGCACCAGG TCACGCGGCT GCGCTACCGG 
AGCGTACGCG AGGTGTGGCA GAGCCTCCCG CCTGGGCCCA CGCAGGGTCA GACGCCTGGC 
GAGCCGGCCG CTAGTCTCAG CGTACTTAAG AACGTGCCCG GCCTCGCCAT CCTACTTTCC 
AAGGACGCGC TGGATCCGCG ACAGCCCGGC TACCAGCCCC CGAATCCCCA TCCTGGTCCC 
TCGTCCCCGC CAGCCGCGCC AGCGTCCAAG AGGAGCCTAG GGGAACCCGC AGCTGGAGAA 
GGCTCCGCGA AGCGATCGCA ACCCGAGCCA GGGGTTGCGG ACGAGGATCA GACGGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Rpp25 is a major target of autoantibodies to the Th/To complex as measured by a novel chemiluminescent assay.
Arthritis research & therapy15(2)R50(2013 Apr)
Mahler M,Gascon C,Patel S,Ceribelli A,Fritzler MJ,Swart A,Chan EK,Satoh M

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

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RPP25 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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