LAX1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LAX1
Entrez Gene ID	54900
Full Name	lymphocyte transmembrane adaptor 1
Synonyms	LAX
General protein information	Preferred Names lymphocyte transmembrane adaptor 1 Names lymphocyte transmembrane adapter 1 LAT-like membrane associated protein linker for activation of x cells membrane-associated adapter protein LAX
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q32.1

mRNA and Protein(s)

mRNA	Protein	Name
NM_001136190.2	NP_001129662.1	lymphocyte transmembrane adapter 1 isoform b
XM_006711397.3	XP_006711460.1	lymphocyte transmembrane adapter 1 isoform X1
NM_001136190.1	NP_001129662.1	lymphocyte transmembrane adapter 1 isoform b
NM_017773.3	NP_060243.2	lymphocyte transmembrane adapter 1 isoform a
NM_001282878.1	NP_001269807.1	lymphocyte transmembrane adapter 1 isoform c
NM_017773.4	NP_060243.2	lymphocyte transmembrane adapter 1 isoform a

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LAX1	XP_001156566.1
Mus musculus (house mouse)	Lax1	NP_001153121.1
Homo sapiens (human)	LAX1	NP_060243.2
Bos taurus (cattle)	LAX1	NP_001015674.1
Rattus norvegicus (Norway rat)	Lax1	NP_001017491.1
	LAX1	XP_001101278.1
Canis lupus familiaris (dog)	LAX1	XP_003434375.2

Gene Ontology
Bibliography

Related articles in PubMed

Rab8 binding to immune cell-specific adaptor LAX facilitates formation of trans-Golgi network-proximal CTLA-4 vesicles for surface expression.
Banton MC, Inder KL, Valk E, Rudd CE, Schneider H
Molecular and cellular biology34(8)1486-99(2014 Apr)

The transmembrane region is responsible for targeting of adaptor protein LAX into "heavy rafts".
Hrdinka M, Otahal P, Horejsi V
PloS one7(5)e36330(2012)

Defining the membrane proteome of NK cells.
Ghosh D, Lippert D, Krokhin O, Cortens JP, Wilkins JA
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)

Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.
Ehret GB, O'Connor AA, Weder A, Cooper RS, Chakravarti A
European journal of human genetics : EJHG17(12)1650-7(2009 Dec)

Negative regulation of TCR signaling by linker for activation of X cells via phosphotyrosine-dependent and -independent mechanisms.
Shapiro MJ, Nguyen CT, Aghajanian H, Zhang W, Shapiro VS
Journal of immunology (Baltimore, Md. : 1950)181(10)7055-61(2008 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TRIM required LAX for binding to Rab8 in a complex, a novel CTLA-4/TRIM/LAX/Rab8 effector complex in the transport of CTLA-4 to the surfaces of T cells
Title: Rab8 binding to immune cell-specific adaptor LAX facilitates formation of trans-Golgi network-proximal CTLA-4 vesicles for surface expression.

We identified the transmembrane domain of LAX as a first motif targeting transmembrane protein constructs to detergent-resistant heavy rafts, a novel type of membrane microdomains containing a number of physiologically important proteins.
Title: The transmembrane region is responsible for targeting of adaptor protein LAX into "heavy rafts".

Observational study of gene-disease association. (HuGE Navigator)
Title: Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.

inhibition of signaling events involved in T cell activation by LAX occurs through mechanisms both dependent on and independent of its tyrosine phosphorylation.
Title: Negative regulation of TCR signaling by linker for activation of X cells via phosphotyrosine-dependent and -independent mechanisms.

functions to negatively regulate signaling in lymphocytes
Title: Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling.

The following LAX1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LAX1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu10984	NM_001282878.1 Latest version!	Homo sapiens lymphocyte transmembrane adaptor 1 (LAX1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu26868	NM_001136190.2 Latest version!	Homo sapiens lymphocyte transmembrane adaptor 1 (LAX1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu27359	NM_017773.4 Latest version!	Homo sapiens lymphocyte transmembrane adaptor 1 (LAX1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu27359	XM_006711397.3 Latest version!	Homo sapiens lymphocyte transmembrane adaptor 1 (LAX1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
View Old Accession Versions >>
OHu26868	NM_001136190.1	Homo sapiens lymphocyte transmembrane adaptor 1 (LAX1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu27359	NM_017773.3	Homo sapiens lymphocyte transmembrane adaptor 1 (LAX1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LAX1 ( NM_001282878.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001269807.1 Homo sapiens lymphocyte transmembrane adaptor 1 (LAX1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu10984
Clone ID Related Accession (Same CDS sequence)	NM_001282878.1
Accession Version	NM_001282878.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 969bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Homo sapiens(human)
Product	lymphocyte transmembrane adapter 1 isoform c
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK000347.1, BC089408.1 and AC114402.2. Transcript Variant: This variant (3) differs in the 5' UTR and represents use of an alternate promoter and initiates translation at downstream start codon, compared to variant 1. It encodes isoform c, which has a shorter N-terminus compared to isoform a. ##Evidence-Data-START## Transcript exon combination :: AK000347.1, SRR1803615.243866.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151358, SAMN03465415 [ECO:0000348] ##Evidence-Data-END##

ATGCCCTTGC TGACTTTGCC ACAAACCAGA CAAAGAGCCA AAAATATTTA TGACATCTTG 
CCTTGGCGAC AGGAAGACCT GGGGAGACAT GAGTCGAGGA GTATGCGCAT TTTCAGTACT 
GAGAGCCTCC TCTCCAGAAA TTCTGAGAGC CCGGAGCATG TGCCCTCCCA AGCAGGCAAT 
GCCTTCCAGG AGCATACAGC CCACATCCAT GCCACAGAGT ACGCGGTGGG TATCTATGAC 
AACGCCATGG TCCCCCAGAT GTGTGGGAAC CTCACTCCCT CGGCACACTG CATCAATGTC 
AGAGCTTCCA GAGACTGCGC AAGCATTTCT TCAGAGGATT CGCATGATTA TGTCAATGTC 
CCCACAGCAG AAGAGATTGC TGAGACTCTA GCTTCTACCA AAAGCCCTTC CAGAAATCTC 
TTTGTTCTTC CCAGTACCCA GAAGCTGGAG TTTACTGAGG AAAGAGATGA GGGCTGTGGA 
GATGCTGGTG ACTGCACCAG TTTGTATTCT CCAGGAGCTG AGGACAGTGA TTCACTCAGC 
AATGGAGAAG GTTCTTCTCA GATCTCAAAT GACTATGTCA ACATGACAGG GTTGGATCTC 
AGTGCCATCC AGGAAAGGCA GCTCTGGGTG GCTTTTCAGT GCTGCAGAGA CTATGAAAAT 
GTTCCAGCAG CAGATCCCAG TGGAAGCCAG CAGCAGGCTG AGAAAGATGT GCCATCCTCA 
AACATAGGTC ATGTCGAGGA CAAGACAGAT GATCCCGGGA CCCATGTCCA ATGTGTCAAA 
AGGACATTCC TTGCTTCAGG GGATTATGCA GACTTTCAGC CATTCACACA GAGTGAGGAC 
AGTCAGATGA AACATAGAGA AGAGATGTCA AATGAGGACT CCAGTGACTA TGAAAATGTG 
CTAACTGCCA AGTTAGGAGG CAGGGACTCT GAGCAGGGGC CTGGCACTCA GCTCCTTCCT 
GATGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001269807.1
CDS	199..1167
Translation	MPLLTLPQTRQRAKNIYDILPWRQEDLGRHESRSMRIFSTESLLSRNSESPEHVPSQAGNAFQEHTAHIHATEYAVGIYDNAMVPQMCGNLTPSAHCINVRASRDCASISSEDSHDYVNVPTAEEIAETLASTKSPSRNLFVLPSTQKLEFTEERDEGCGDAGDCTSLYSPGAEDSDSLSNGEGSSQISNDYVNMTGLDLSAIQERQLWVAFQCCRDYENVPAADPSGSQQQAEKDVPSSNIGHVEDKTDDPGTHVQCVKRTFLASGDYADFQPFTQSEDSQMKHREEMSNEDSSDYENVLTAKLGGRDSEQGPGTQLLPDE

Target ORF information:

RefSeq Version	NM_001282878.1
Organism	Homo sapiens(human)
Definition	Homo sapiens lymphocyte transmembrane adaptor 1 (LAX1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001282878.1

ORF Insert Sequence:

ATGCCCTTGC TGACTTTGCC ACAAACCAGA CAAAGAGCCA AAAATATTTA TGACATCTTG 
CCTTGGCGAC AGGAAGACCT GGGGAGACAT GAGTCGAGGA GTATGCGCAT TTTCAGTACT 
GAGAGCCTCC TCTCCAGAAA TTCTGAGAGC CCGGAGCATG TGCCCTCCCA AGCAGGCAAT 
GCCTTCCAGG AGCATACAGC CCACATCCAT GCCACAGAGT ACGCGGTGGG TATCTATGAC 
AACGCCATGG TCCCCCAGAT GTGTGGGAAC CTCACTCCCT CGGCACACTG CATCAATGTC 
AGAGCTTCCA GAGACTGCGC AAGCATTTCT TCAGAGGATT CGCATGATTA TGTCAATGTC 
CCCACAGCAG AAGAGATTGC TGAGACTCTA GCTTCTACCA AAAGCCCTTC CAGAAATCTC 
TTTGTTCTTC CCAGTACCCA GAAGCTGGAG TTTACTGAGG AAAGAGATGA GGGCTGTGGA 
GATGCTGGTG ACTGCACCAG TTTGTATTCT CCAGGAGCTG AGGACAGTGA TTCACTCAGC 
AATGGAGAAG GTTCTTCTCA GATCTCAAAT GACTATGTCA ACATGACAGG GTTGGATCTC 
AGTGCCATCC AGGAAAGGCA GCTCTGGGTG GCTTTTCAGT GCTGCAGAGA CTATGAAAAT 
GTTCCAGCAG CAGATCCCAG TGGAAGCCAG CAGCAGGCTG AGAAAGATGT GCCATCCTCA 
AACATAGGTC ATGTCGAGGA CAAGACAGAT GATCCCGGGA CCCATGTCCA ATGTGTCAAA 
AGGACATTCC TTGCTTCAGG GGATTATGCA GACTTTCAGC CATTCACACA GAGTGAGGAC 
AGTCAGATGA AACATAGAGA AGAGATGTCA AATGAGGACT CCAGTGACTA TGAAAATGTG 
CTAACTGCCA AGTTAGGAGG CAGGGACTCT GAGCAGGGGC CTGGCACTCA GCTCCTTCCT 
GATGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LAX1 ( NM_001136190.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001129662.1 Homo sapiens lymphocyte transmembrane adaptor 1 (LAX1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu26868
Clone ID Related Accession (Same CDS sequence)	NM_001136190.2 , NM_001136190.1
Accession Version	NM_001136190.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1149bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-30
Organism	Homo sapiens(human)
Product	lymphocyte transmembrane adapter 1 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DC414389.1, BC089408.1 and AC114402.2. On May 31, 2019 this sequence version replaced NM_001136190.1. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a. ##Evidence-Data-START## Transcript exon combination :: AK301421.1, SRR1163658.89365.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGAGATCGC ACTTCCTGCA GTGGGCATTA GCCACGTCCA GAAATAAAGA CCAGATCACC 
AACATCTTTT CCGGGTTTGC GGGACTCCTC GCCATCCTCC TGGTCGTTGC GGTTTTCTGC 
ATCTTGTGGA ATTGGAATAA ACGGAAGAAG CGACAAGTTC CTTACCTCCG AGTTACCGTC 
ATGCCCTTGC TGACTTTGCC ACAAACCAGA CAAAGAGCCA AAAATATTTA TGACATCTTG 
CCTTGGCGAC AGGAAGACCT GGGGAGACAT GAGTCGAGGA GTATGCGCAT TTTCAGTACT 
GAGAGCCTCC TCTCCAGAAA TTCTGAGAGC CCGGAGCATG TGCCCTCCCA AGCAGGCAAT 
GCCTTCCAGG AGCATACAGC CCACATCCAT GCCACAGAGT ACGCGGTGGG TATCTATGAC 
AACGCCATGG TCCCCCAGAT GTGTGGGAAC CTCACTCCCT CGGCACACTG CATCAATGTC 
AGAGCTTCCA GAGACTGCGC AAGCATTTCT TCAGAGGATT CGCATGATTA TGTCAATGTC 
CCCACAGCAG AAGAGATTGC TGAGACTCTA GCTTCTACCA AAAGCCCTTC CAGAAATCTC 
TTTGTTCTTC CCAGTACCCA GAAGCTGGAG TTTACTGAGG AAAGAGATGA GGGCTGTGGA 
GATGCTGGTG ACTGCACCAG TTTGTATTCT CCAGGAGCTG AGGACAGTGA TTCACTCAGC 
AATGGAGAAG GTTCTTCTCA GATCTCAAAT GACTATGTCA ACATGACAGG GTTGGATCTC 
AGTGCCATCC AGGAAAGGCA GCTCTGGGTG GCTTTTCAGT GCTGCAGAGA CTATGAAAAT 
GTTCCAGCAG CAGATCCCAG TGGAAGCCAG CAGCAGGCTG AGAAAGATGT GCCATCCTCA 
AACATAGGTC ATGTCGAGGA CAAGACAGAT GATCCCGGGA CCCATGTCCA ATGTGTCAAA 
AGGACATTCC TTGCTTCAGG GGATTATGCA GACTTTCAGC CATTCACACA GAGTGAGGAC 
AGTCAGATGA AACATAGAGA AGAGATGTCA AATGAGGACT CCAGTGACTA TGAAAATGTG 
CTAACTGCCA AGTTAGGAGG CAGGGACTCT GAGCAGGGGC CTGGCACTCA GCTCCTTCCT 
GATGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001129662.1
CDS	161..1309
Translation	MRSHFLQWALATSRNKDQITNIFSGFAGLLAILLVVAVFCILWNWNKRKKRQVPYLRVTVMPLLTLPQTRQRAKNIYDILPWRQEDLGRHESRSMRIFSTESLLSRNSESPEHVPSQAGNAFQEHTAHIHATEYAVGIYDNAMVPQMCGNLTPSAHCINVRASRDCASISSEDSHDYVNVPTAEEIAETLASTKSPSRNLFVLPSTQKLEFTEERDEGCGDAGDCTSLYSPGAEDSDSLSNGEGSSQISNDYVNMTGLDLSAIQERQLWVAFQCCRDYENVPAADPSGSQQQAEKDVPSSNIGHVEDKTDDPGTHVQCVKRTFLASGDYADFQPFTQSEDSQMKHREEMSNEDSSDYENVLTAKLGGRDSEQGPGTQLLPDE

Target ORF information:

RefSeq Version	NM_001136190.2
Organism	Homo sapiens(human)
Definition	Homo sapiens lymphocyte transmembrane adaptor 1 (LAX1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001136190.2

ORF Insert Sequence:

ATGAGATCGC ACTTCCTGCA GTGGGCATTA GCCACGTCCA GAAATAAAGA CCAGATCACC 
AACATCTTTT CCGGGTTTGC GGGACTCCTC GCCATCCTCC TGGTCGTTGC GGTTTTCTGC 
ATCTTGTGGA ATTGGAATAA ACGGAAGAAG CGACAAGTTC CTTACCTCCG AGTTACCGTC 
ATGCCCTTGC TGACTTTGCC ACAAACCAGA CAAAGAGCCA AAAATATTTA TGACATCTTG 
CCTTGGCGAC AGGAAGACCT GGGGAGACAT GAGTCGAGGA GTATGCGCAT TTTCAGTACT 
GAGAGCCTCC TCTCCAGAAA TTCTGAGAGC CCGGAGCATG TGCCCTCCCA AGCAGGCAAT 
GCCTTCCAGG AGCATACAGC CCACATCCAT GCCACAGAGT ACGCGGTGGG TATCTATGAC 
AACGCCATGG TCCCCCAGAT GTGTGGGAAC CTCACTCCCT CGGCACACTG CATCAATGTC 
AGAGCTTCCA GAGACTGCGC AAGCATTTCT TCAGAGGATT CGCATGATTA TGTCAATGTC 
CCCACAGCAG AAGAGATTGC TGAGACTCTA GCTTCTACCA AAAGCCCTTC CAGAAATCTC 
TTTGTTCTTC CCAGTACCCA GAAGCTGGAG TTTACTGAGG AAAGAGATGA GGGCTGTGGA 
GATGCTGGTG ACTGCACCAG TTTGTATTCT CCAGGAGCTG AGGACAGTGA TTCACTCAGC 
AATGGAGAAG GTTCTTCTCA GATCTCAAAT GACTATGTCA ACATGACAGG GTTGGATCTC 
AGTGCCATCC AGGAAAGGCA GCTCTGGGTG GCTTTTCAGT GCTGCAGAGA CTATGAAAAT 
GTTCCAGCAG CAGATCCCAG TGGAAGCCAG CAGCAGGCTG AGAAAGATGT GCCATCCTCA 
AACATAGGTC ATGTCGAGGA CAAGACAGAT GATCCCGGGA CCCATGTCCA ATGTGTCAAA 
AGGACATTCC TTGCTTCAGG GGATTATGCA GACTTTCAGC CATTCACACA GAGTGAGGAC 
AGTCAGATGA AACATAGAGA AGAGATGTCA AATGAGGACT CCAGTGACTA TGAAAATGTG 
CTAACTGCCA AGTTAGGAGG CAGGGACTCT GAGCAGGGGC CTGGCACTCA GCTCCTTCCT 
GATGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LAX1 ( NM_001136190.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001129662.1 Homo sapiens lymphocyte transmembrane adaptor 1 (LAX1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu26868
Clone ID Related Accession (Same CDS sequence)	NM_001136190.2 , NM_001136190.1
Accession Version	NM_001136190.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1149bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	lymphocyte transmembrane adapter 1 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DC414389.1, BC089408.1 and AC114402.2. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.89365.1, AK301421.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGAGATCGC ACTTCCTGCA GTGGGCATTA GCCACGTCCA GAAATAAAGA CCAGATCACC 
AACATCTTTT CCGGGTTTGC GGGACTCCTC GCCATCCTCC TGGTCGTTGC GGTTTTCTGC 
ATCTTGTGGA ATTGGAATAA ACGGAAGAAG CGACAAGTTC CTTACCTCCG AGTTACCGTC 
ATGCCCTTGC TGACTTTGCC ACAAACCAGA CAAAGAGCCA AAAATATTTA TGACATCTTG 
CCTTGGCGAC AGGAAGACCT GGGGAGACAT GAGTCGAGGA GTATGCGCAT TTTCAGTACT 
GAGAGCCTCC TCTCCAGAAA TTCTGAGAGC CCGGAGCATG TGCCCTCCCA AGCAGGCAAT 
GCCTTCCAGG AGCATACAGC CCACATCCAT GCCACAGAGT ACGCGGTGGG TATCTATGAC 
AACGCCATGG TCCCCCAGAT GTGTGGGAAC CTCACTCCCT CGGCACACTG CATCAATGTC 
AGAGCTTCCA GAGACTGCGC AAGCATTTCT TCAGAGGATT CGCATGATTA TGTCAATGTC 
CCCACAGCAG AAGAGATTGC TGAGACTCTA GCTTCTACCA AAAGCCCTTC CAGAAATCTC 
TTTGTTCTTC CCAGTACCCA GAAGCTGGAG TTTACTGAGG AAAGAGATGA GGGCTGTGGA 
GATGCTGGTG ACTGCACCAG TTTGTATTCT CCAGGAGCTG AGGACAGTGA TTCACTCAGC 
AATGGAGAAG GTTCTTCTCA GATCTCAAAT GACTATGTCA ACATGACAGG GTTGGATCTC 
AGTGCCATCC AGGAAAGGCA GCTCTGGGTG GCTTTTCAGT GCTGCAGAGA CTATGAAAAT 
GTTCCAGCAG CAGATCCCAG TGGAAGCCAG CAGCAGGCTG AGAAAGATGT GCCATCCTCA 
AACATAGGTC ATGTCGAGGA CAAGACAGAT GATCCCGGGA CCCATGTCCA ATGTGTCAAA 
AGGACATTCC TTGCTTCAGG GGATTATGCA GACTTTCAGC CATTCACACA GAGTGAGGAC 
AGTCAGATGA AACATAGAGA AGAGATGTCA AATGAGGACT CCAGTGACTA TGAAAATGTG 
CTAACTGCCA AGTTAGGAGG CAGGGACTCT GAGCAGGGGC CTGGCACTCA GCTCCTTCCT 
GATGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001129662.1
CDS	188..1336
Translation	MRSHFLQWALATSRNKDQITNIFSGFAGLLAILLVVAVFCILWNWNKRKKRQVPYLRVTVMPLLTLPQTRQRAKNIYDILPWRQEDLGRHESRSMRIFSTESLLSRNSESPEHVPSQAGNAFQEHTAHIHATEYAVGIYDNAMVPQMCGNLTPSAHCINVRASRDCASISSEDSHDYVNVPTAEEIAETLASTKSPSRNLFVLPSTQKLEFTEERDEGCGDAGDCTSLYSPGAEDSDSLSNGEGSSQISNDYVNMTGLDLSAIQERQLWVAFQCCRDYENVPAADPSGSQQQAEKDVPSSNIGHVEDKTDDPGTHVQCVKRTFLASGDYADFQPFTQSEDSQMKHREEMSNEDSSDYENVLTAKLGGRDSEQGPGTQLLPDE

Target ORF information:

RefSeq Version	NM_001136190.1
Organism	Homo sapiens(human)
Definition	Homo sapiens lymphocyte transmembrane adaptor 1 (LAX1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001136190.1

ORF Insert Sequence:

ATGAGATCGC ACTTCCTGCA GTGGGCATTA GCCACGTCCA GAAATAAAGA CCAGATCACC 
AACATCTTTT CCGGGTTTGC GGGACTCCTC GCCATCCTCC TGGTCGTTGC GGTTTTCTGC 
ATCTTGTGGA ATTGGAATAA ACGGAAGAAG CGACAAGTTC CTTACCTCCG AGTTACCGTC 
ATGCCCTTGC TGACTTTGCC ACAAACCAGA CAAAGAGCCA AAAATATTTA TGACATCTTG 
CCTTGGCGAC AGGAAGACCT GGGGAGACAT GAGTCGAGGA GTATGCGCAT TTTCAGTACT 
GAGAGCCTCC TCTCCAGAAA TTCTGAGAGC CCGGAGCATG TGCCCTCCCA AGCAGGCAAT 
GCCTTCCAGG AGCATACAGC CCACATCCAT GCCACAGAGT ACGCGGTGGG TATCTATGAC 
AACGCCATGG TCCCCCAGAT GTGTGGGAAC CTCACTCCCT CGGCACACTG CATCAATGTC 
AGAGCTTCCA GAGACTGCGC AAGCATTTCT TCAGAGGATT CGCATGATTA TGTCAATGTC 
CCCACAGCAG AAGAGATTGC TGAGACTCTA GCTTCTACCA AAAGCCCTTC CAGAAATCTC 
TTTGTTCTTC CCAGTACCCA GAAGCTGGAG TTTACTGAGG AAAGAGATGA GGGCTGTGGA 
GATGCTGGTG ACTGCACCAG TTTGTATTCT CCAGGAGCTG AGGACAGTGA TTCACTCAGC 
AATGGAGAAG GTTCTTCTCA GATCTCAAAT GACTATGTCA ACATGACAGG GTTGGATCTC 
AGTGCCATCC AGGAAAGGCA GCTCTGGGTG GCTTTTCAGT GCTGCAGAGA CTATGAAAAT 
GTTCCAGCAG CAGATCCCAG TGGAAGCCAG CAGCAGGCTG AGAAAGATGT GCCATCCTCA 
AACATAGGTC ATGTCGAGGA CAAGACAGAT GATCCCGGGA CCCATGTCCA ATGTGTCAAA 
AGGACATTCC TTGCTTCAGG GGATTATGCA GACTTTCAGC CATTCACACA GAGTGAGGAC 
AGTCAGATGA AACATAGAGA AGAGATGTCA AATGAGGACT CCAGTGACTA TGAAAATGTG 
CTAACTGCCA AGTTAGGAGG CAGGGACTCT GAGCAGGGGC CTGGCACTCA GCTCCTTCCT 
GATGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LAX1 ( NM_017773.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_060243.2 Homo sapiens lymphocyte transmembrane adaptor 1 (LAX1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu27359
Clone ID Related Accession (Same CDS sequence)	XM_006711397.3 , NM_017773.3 , NM_017773.4
Accession Version	NM_017773.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1197bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	lymphocyte transmembrane adapter 1 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DC414389.1, BC089408.1 and AC114402.2. On Oct 24, 2008 this sequence version replaced NM_017773.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). ##Evidence-Data-START## Transcript exon combination :: BC089408.1, SRR1163655.294900.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGGATGGTG TCACTCCAAC CCTTTCGACA ATCAGAGGGA GGACCTTGGA GTCCAGCACT 
CTGCATGTGA CTCCCCGCAG CCTGGACAGA AATAAAGACC AGATCACCAA CATCTTTTCC 
GGGTTTGCGG GACTCCTCGC CATCCTCCTG GTCGTTGCGG TTTTCTGCAT CTTGTGGAAT 
TGGAATAAAC GGAAGAAGCG ACAAGTTCCT TACCTCCGAG TTACCGTCAT GCCCTTGCTG 
ACTTTGCCAC AAACCAGACA AAGAGCCAAA AATATTTATG ACATCTTGCC TTGGCGACAG 
GAAGACCTGG GGAGACATGA GTCGAGGAGT ATGCGCATTT TCAGTACTGA GAGCCTCCTC 
TCCAGAAATT CTGAGAGCCC GGAGCATGTG CCCTCCCAAG CAGGCAATGC CTTCCAGGAG 
CATACAGCCC ACATCCATGC CACAGAGTAC GCGGTGGGTA TCTATGACAA CGCCATGGTC 
CCCCAGATGT GTGGGAACCT CACTCCCTCG GCACACTGCA TCAATGTCAG AGCTTCCAGA 
GACTGCGCAA GCATTTCTTC AGAGGATTCG CATGATTATG TCAATGTCCC CACAGCAGAA 
GAGATTGCTG AGACTCTAGC TTCTACCAAA AGCCCTTCCA GAAATCTCTT TGTTCTTCCC 
AGTACCCAGA AGCTGGAGTT TACTGAGGAA AGAGATGAGG GCTGTGGAGA TGCTGGTGAC 
TGCACCAGTT TGTATTCTCC AGGAGCTGAG GACAGTGATT CACTCAGCAA TGGAGAAGGT 
TCTTCTCAGA TCTCAAATGA CTATGTCAAC ATGACAGGGT TGGATCTCAG TGCCATCCAG 
GAAAGGCAGC TCTGGGTGGC TTTTCAGTGC TGCAGAGACT ATGAAAATGT TCCAGCAGCA 
GATCCCAGTG GAAGCCAGCA GCAGGCTGAG AAAGATGTGC CATCCTCAAA CATAGGTCAT 
GTCGAGGACA AGACAGATGA TCCCGGGACC CATGTCCAAT GTGTCAAAAG GACATTCCTT 
GCTTCAGGGG ATTATGCAGA CTTTCAGCCA TTCACACAGA GTGAGGACAG TCAGATGAAA 
CATAGAGAAG AGATGTCAAA TGAGGACTCC AGTGACTATG AAAATGTGCT AACTGCCAAG 
TTAGGAGGCA GGGACTCTGA GCAGGGGCCT GGCACTCAGC TCCTTCCTGA TGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060243.2
CDS	411..1607
Translation	MDGVTPTLSTIRGRTLESSTLHVTPRSLDRNKDQITNIFSGFAGLLAILLVVAVFCILWNWNKRKKRQVPYLRVTVMPLLTLPQTRQRAKNIYDILPWRQEDLGRHESRSMRIFSTESLLSRNSESPEHVPSQAGNAFQEHTAHIHATEYAVGIYDNAMVPQMCGNLTPSAHCINVRASRDCASISSEDSHDYVNVPTAEEIAETLASTKSPSRNLFVLPSTQKLEFTEERDEGCGDAGDCTSLYSPGAEDSDSLSNGEGSSQISNDYVNMTGLDLSAIQERQLWVAFQCCRDYENVPAADPSGSQQQAEKDVPSSNIGHVEDKTDDPGTHVQCVKRTFLASGDYADFQPFTQSEDSQMKHREEMSNEDSSDYENVLTAKLGGRDSEQGPGTQLLPDE

Target ORF information:

RefSeq Version	NM_017773.3
Organism	Homo sapiens(human)
Definition	Homo sapiens lymphocyte transmembrane adaptor 1 (LAX1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017773.3

ORF Insert Sequence:

ATGGATGGTG TCACTCCAAC CCTTTCGACA ATCAGAGGGA GGACCTTGGA GTCCAGCACT 
CTGCATGTGA CTCCCCGCAG CCTGGACAGA AATAAAGACC AGATCACCAA CATCTTTTCC 
GGGTTTGCGG GACTCCTCGC CATCCTCCTG GTCGTTGCGG TTTTCTGCAT CTTGTGGAAT 
TGGAATAAAC GGAAGAAGCG ACAAGTTCCT TACCTCCGAG TTACCGTCAT GCCCTTGCTG 
ACTTTGCCAC AAACCAGACA AAGAGCCAAA AATATTTATG ACATCTTGCC TTGGCGACAG 
GAAGACCTGG GGAGACATGA GTCGAGGAGT ATGCGCATTT TCAGTACTGA GAGCCTCCTC 
TCCAGAAATT CTGAGAGCCC GGAGCATGTG CCCTCCCAAG CAGGCAATGC CTTCCAGGAG 
CATACAGCCC ACATCCATGC CACAGAGTAC GCGGTGGGTA TCTATGACAA CGCCATGGTC 
CCCCAGATGT GTGGGAACCT CACTCCCTCG GCACACTGCA TCAATGTCAG AGCTTCCAGA 
GACTGCGCAA GCATTTCTTC AGAGGATTCG CATGATTATG TCAATGTCCC CACAGCAGAA 
GAGATTGCTG AGACTCTAGC TTCTACCAAA AGCCCTTCCA GAAATCTCTT TGTTCTTCCC 
AGTACCCAGA AGCTGGAGTT TACTGAGGAA AGAGATGAGG GCTGTGGAGA TGCTGGTGAC 
TGCACCAGTT TGTATTCTCC AGGAGCTGAG GACAGTGATT CACTCAGCAA TGGAGAAGGT 
TCTTCTCAGA TCTCAAATGA CTATGTCAAC ATGACAGGGT TGGATCTCAG TGCCATCCAG 
GAAAGGCAGC TCTGGGTGGC TTTTCAGTGC TGCAGAGACT ATGAAAATGT TCCAGCAGCA 
GATCCCAGTG GAAGCCAGCA GCAGGCTGAG AAAGATGTGC CATCCTCAAA CATAGGTCAT 
GTCGAGGACA AGACAGATGA TCCCGGGACC CATGTCCAAT GTGTCAAAAG GACATTCCTT 
GCTTCAGGGG ATTATGCAGA CTTTCAGCCA TTCACACAGA GTGAGGACAG TCAGATGAAA 
CATAGAGAAG AGATGTCAAA TGAGGACTCC AGTGACTATG AAAATGTGCT AACTGCCAAG 
TTAGGAGGCA GGGACTCTGA GCAGGGGCCT GGCACTCAGC TCCTTCCTGA TGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LAX1 ( NM_017773.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_060243.2 Homo sapiens lymphocyte transmembrane adaptor 1 (LAX1), transcript variant 1, mRNA.

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CloneID	OHu27359
Clone ID Related Accession (Same CDS sequence)	XM_006711397.3 , NM_017773.3 , NM_017773.4
Accession Version	NM_017773.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1197bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	lymphocyte transmembrane adapter 1 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DC414389.1, BC089408.1 and AC114402.2. On May 17, 2019 this sequence version replaced NM_017773.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). ##Evidence-Data-START## Transcript exon combination :: BC089408.1, SRR1163655.64134.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000442561.7/ ENSP00000406970.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGGATGGTG TCACTCCAAC CCTTTCGACA ATCAGAGGGA GGACCTTGGA GTCCAGCACT 
CTGCATGTGA CTCCCCGCAG CCTGGACAGA AATAAAGACC AGATCACCAA CATCTTTTCC 
GGGTTTGCGG GACTCCTCGC CATCCTCCTG GTCGTTGCGG TTTTCTGCAT CTTGTGGAAT 
TGGAATAAAC GGAAGAAGCG ACAAGTTCCT TACCTCCGAG TTACCGTCAT GCCCTTGCTG 
ACTTTGCCAC AAACCAGACA AAGAGCCAAA AATATTTATG ACATCTTGCC TTGGCGACAG 
GAAGACCTGG GGAGACATGA GTCGAGGAGT ATGCGCATTT TCAGTACTGA GAGCCTCCTC 
TCCAGAAATT CTGAGAGCCC GGAGCATGTG CCCTCCCAAG CAGGCAATGC CTTCCAGGAG 
CATACAGCCC ACATCCATGC CACAGAGTAC GCGGTGGGTA TCTATGACAA CGCCATGGTC 
CCCCAGATGT GTGGGAACCT CACTCCCTCG GCACACTGCA TCAATGTCAG AGCTTCCAGA 
GACTGCGCAA GCATTTCTTC AGAGGATTCG CATGATTATG TCAATGTCCC CACAGCAGAA 
GAGATTGCTG AGACTCTAGC TTCTACCAAA AGCCCTTCCA GAAATCTCTT TGTTCTTCCC 
AGTACCCAGA AGCTGGAGTT TACTGAGGAA AGAGATGAGG GCTGTGGAGA TGCTGGTGAC 
TGCACCAGTT TGTATTCTCC AGGAGCTGAG GACAGTGATT CACTCAGCAA TGGAGAAGGT 
TCTTCTCAGA TCTCAAATGA CTATGTCAAC ATGACAGGGT TGGATCTCAG TGCCATCCAG 
GAAAGGCAGC TCTGGGTGGC TTTTCAGTGC TGCAGAGACT ATGAAAATGT TCCAGCAGCA 
GATCCCAGTG GAAGCCAGCA GCAGGCTGAG AAAGATGTGC CATCCTCAAA CATAGGTCAT 
GTCGAGGACA AGACAGATGA TCCCGGGACC CATGTCCAAT GTGTCAAAAG GACATTCCTT 
GCTTCAGGGG ATTATGCAGA CTTTCAGCCA TTCACACAGA GTGAGGACAG TCAGATGAAA 
CATAGAGAAG AGATGTCAAA TGAGGACTCC AGTGACTATG AAAATGTGCT AACTGCCAAG 
TTAGGAGGCA GGGACTCTGA GCAGGGGCCT GGCACTCAGC TCCTTCCTGA TGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060243.2
CDS	384..1580
Translation	MDGVTPTLSTIRGRTLESSTLHVTPRSLDRNKDQITNIFSGFAGLLAILLVVAVFCILWNWNKRKKRQVPYLRVTVMPLLTLPQTRQRAKNIYDILPWRQEDLGRHESRSMRIFSTESLLSRNSESPEHVPSQAGNAFQEHTAHIHATEYAVGIYDNAMVPQMCGNLTPSAHCINVRASRDCASISSEDSHDYVNVPTAEEIAETLASTKSPSRNLFVLPSTQKLEFTEERDEGCGDAGDCTSLYSPGAEDSDSLSNGEGSSQISNDYVNMTGLDLSAIQERQLWVAFQCCRDYENVPAADPSGSQQQAEKDVPSSNIGHVEDKTDDPGTHVQCVKRTFLASGDYADFQPFTQSEDSQMKHREEMSNEDSSDYENVLTAKLGGRDSEQGPGTQLLPDE

Target ORF information:

RefSeq Version	NM_017773.4
Organism	Homo sapiens(human)
Definition	Homo sapiens lymphocyte transmembrane adaptor 1 (LAX1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017773.4

ORF Insert Sequence:

ATGGATGGTG TCACTCCAAC CCTTTCGACA ATCAGAGGGA GGACCTTGGA GTCCAGCACT 
CTGCATGTGA CTCCCCGCAG CCTGGACAGA AATAAAGACC AGATCACCAA CATCTTTTCC 
GGGTTTGCGG GACTCCTCGC CATCCTCCTG GTCGTTGCGG TTTTCTGCAT CTTGTGGAAT 
TGGAATAAAC GGAAGAAGCG ACAAGTTCCT TACCTCCGAG TTACCGTCAT GCCCTTGCTG 
ACTTTGCCAC AAACCAGACA AAGAGCCAAA AATATTTATG ACATCTTGCC TTGGCGACAG 
GAAGACCTGG GGAGACATGA GTCGAGGAGT ATGCGCATTT TCAGTACTGA GAGCCTCCTC 
TCCAGAAATT CTGAGAGCCC GGAGCATGTG CCCTCCCAAG CAGGCAATGC CTTCCAGGAG 
CATACAGCCC ACATCCATGC CACAGAGTAC GCGGTGGGTA TCTATGACAA CGCCATGGTC 
CCCCAGATGT GTGGGAACCT CACTCCCTCG GCACACTGCA TCAATGTCAG AGCTTCCAGA 
GACTGCGCAA GCATTTCTTC AGAGGATTCG CATGATTATG TCAATGTCCC CACAGCAGAA 
GAGATTGCTG AGACTCTAGC TTCTACCAAA AGCCCTTCCA GAAATCTCTT TGTTCTTCCC 
AGTACCCAGA AGCTGGAGTT TACTGAGGAA AGAGATGAGG GCTGTGGAGA TGCTGGTGAC 
TGCACCAGTT TGTATTCTCC AGGAGCTGAG GACAGTGATT CACTCAGCAA TGGAGAAGGT 
TCTTCTCAGA TCTCAAATGA CTATGTCAAC ATGACAGGGT TGGATCTCAG TGCCATCCAG 
GAAAGGCAGC TCTGGGTGGC TTTTCAGTGC TGCAGAGACT ATGAAAATGT TCCAGCAGCA 
GATCCCAGTG GAAGCCAGCA GCAGGCTGAG AAAGATGTGC CATCCTCAAA CATAGGTCAT 
GTCGAGGACA AGACAGATGA TCCCGGGACC CATGTCCAAT GTGTCAAAAG GACATTCCTT 
GCTTCAGGGG ATTATGCAGA CTTTCAGCCA TTCACACAGA GTGAGGACAG TCAGATGAAA 
CATAGAGAAG AGATGTCAAA TGAGGACTCC AGTGACTATG AAAATGTGCT AACTGCCAAG 
TTAGGAGGCA GGGACTCTGA GCAGGGGCCT GGCACTCAGC TCCTTCCTGA TGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LAX1 ( XM_006711397.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_006711460.1 Homo sapiens lymphocyte transmembrane adaptor 1 (LAX1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu27359
Clone ID Related Accession (Same CDS sequence)	XM_006711397.3 , NM_017773.3 , NM_017773.4
Accession Version	XM_006711397.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1197bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	lymphocyte transmembrane adapter 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006711397.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATGGTG TCACTCCAAC CCTTTCGACA ATCAGAGGGA GGACCTTGGA GTCCAGCACT 
CTGCATGTGA CTCCCCGCAG CCTGGACAGA AATAAAGACC AGATCACCAA CATCTTTTCC 
GGGTTTGCGG GACTCCTCGC CATCCTCCTG GTCGTTGCGG TTTTCTGCAT CTTGTGGAAT 
TGGAATAAAC GGAAGAAGCG ACAAGTTCCT TACCTCCGAG TTACCGTCAT GCCCTTGCTG 
ACTTTGCCAC AAACCAGACA AAGAGCCAAA AATATTTATG ACATCTTGCC TTGGCGACAG 
GAAGACCTGG GGAGACATGA GTCGAGGAGT ATGCGCATTT TCAGTACTGA GAGCCTCCTC 
TCCAGAAATT CTGAGAGCCC GGAGCATGTG CCCTCCCAAG CAGGCAATGC CTTCCAGGAG 
CATACAGCCC ACATCCATGC CACAGAGTAC GCGGTGGGTA TCTATGACAA CGCCATGGTC 
CCCCAGATGT GTGGGAACCT CACTCCCTCG GCACACTGCA TCAATGTCAG AGCTTCCAGA 
GACTGCGCAA GCATTTCTTC AGAGGATTCG CATGATTATG TCAATGTCCC CACAGCAGAA 
GAGATTGCTG AGACTCTAGC TTCTACCAAA AGCCCTTCCA GAAATCTCTT TGTTCTTCCC 
AGTACCCAGA AGCTGGAGTT TACTGAGGAA AGAGATGAGG GCTGTGGAGA TGCTGGTGAC 
TGCACCAGTT TGTATTCTCC AGGAGCTGAG GACAGTGATT CACTCAGCAA TGGAGAAGGT 
TCTTCTCAGA TCTCAAATGA CTATGTCAAC ATGACAGGGT TGGATCTCAG TGCCATCCAG 
GAAAGGCAGC TCTGGGTGGC TTTTCAGTGC TGCAGAGACT ATGAAAATGT TCCAGCAGCA 
GATCCCAGTG GAAGCCAGCA GCAGGCTGAG AAAGATGTGC CATCCTCAAA CATAGGTCAT 
GTCGAGGACA AGACAGATGA TCCCGGGACC CATGTCCAAT GTGTCAAAAG GACATTCCTT 
GCTTCAGGGG ATTATGCAGA CTTTCAGCCA TTCACACAGA GTGAGGACAG TCAGATGAAA 
CATAGAGAAG AGATGTCAAA TGAGGACTCC AGTGACTATG AAAATGTGCT AACTGCCAAG 
TTAGGAGGCA GGGACTCTGA GCAGGGGCCT GGCACTCAGC TCCTTCCTGA TGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006711460.1
CDS	302..1498
Translation	MDGVTPTLSTIRGRTLESSTLHVTPRSLDRNKDQITNIFSGFAGLLAILLVVAVFCILWNWNKRKKRQVPYLRVTVMPLLTLPQTRQRAKNIYDILPWRQEDLGRHESRSMRIFSTESLLSRNSESPEHVPSQAGNAFQEHTAHIHATEYAVGIYDNAMVPQMCGNLTPSAHCINVRASRDCASISSEDSHDYVNVPTAEEIAETLASTKSPSRNLFVLPSTQKLEFTEERDEGCGDAGDCTSLYSPGAEDSDSLSNGEGSSQISNDYVNMTGLDLSAIQERQLWVAFQCCRDYENVPAADPSGSQQQAEKDVPSSNIGHVEDKTDDPGTHVQCVKRTFLASGDYADFQPFTQSEDSQMKHREEMSNEDSSDYENVLTAKLGGRDSEQGPGTQLLPDE

Target ORF information:

RefSeq Version	XM_006711397.3
Organism	Homo sapiens(human)
Definition	Homo sapiens lymphocyte transmembrane adaptor 1 (LAX1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006711397.3

ORF Insert Sequence:

ATGGATGGTG TCACTCCAAC CCTTTCGACA ATCAGAGGGA GGACCTTGGA GTCCAGCACT 
CTGCATGTGA CTCCCCGCAG CCTGGACAGA AATAAAGACC AGATCACCAA CATCTTTTCC 
GGGTTTGCGG GACTCCTCGC CATCCTCCTG GTCGTTGCGG TTTTCTGCAT CTTGTGGAAT 
TGGAATAAAC GGAAGAAGCG ACAAGTTCCT TACCTCCGAG TTACCGTCAT GCCCTTGCTG 
ACTTTGCCAC AAACCAGACA AAGAGCCAAA AATATTTATG ACATCTTGCC TTGGCGACAG 
GAAGACCTGG GGAGACATGA GTCGAGGAGT ATGCGCATTT TCAGTACTGA GAGCCTCCTC 
TCCAGAAATT CTGAGAGCCC GGAGCATGTG CCCTCCCAAG CAGGCAATGC CTTCCAGGAG 
CATACAGCCC ACATCCATGC CACAGAGTAC GCGGTGGGTA TCTATGACAA CGCCATGGTC 
CCCCAGATGT GTGGGAACCT CACTCCCTCG GCACACTGCA TCAATGTCAG AGCTTCCAGA 
GACTGCGCAA GCATTTCTTC AGAGGATTCG CATGATTATG TCAATGTCCC CACAGCAGAA 
GAGATTGCTG AGACTCTAGC TTCTACCAAA AGCCCTTCCA GAAATCTCTT TGTTCTTCCC 
AGTACCCAGA AGCTGGAGTT TACTGAGGAA AGAGATGAGG GCTGTGGAGA TGCTGGTGAC 
TGCACCAGTT TGTATTCTCC AGGAGCTGAG GACAGTGATT CACTCAGCAA TGGAGAAGGT 
TCTTCTCAGA TCTCAAATGA CTATGTCAAC ATGACAGGGT TGGATCTCAG TGCCATCCAG 
GAAAGGCAGC TCTGGGTGGC TTTTCAGTGC TGCAGAGACT ATGAAAATGT TCCAGCAGCA 
GATCCCAGTG GAAGCCAGCA GCAGGCTGAG AAAGATGTGC CATCCTCAAA CATAGGTCAT 
GTCGAGGACA AGACAGATGA TCCCGGGACC CATGTCCAAT GTGTCAAAAG GACATTCCTT 
GCTTCAGGGG ATTATGCAGA CTTTCAGCCA TTCACACAGA GTGAGGACAG TCAGATGAAA 
CATAGAGAAG AGATGTCAAA TGAGGACTCC AGTGACTATG AAAATGTGCT AACTGCCAAG 
TTAGGAGGCA GGGACTCTGA GCAGGGGCCT GGCACTCAGC TCCTTCCTGA TGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Rab8 binding to immune cell-specific adaptor LAX facilitates formation of trans-Golgi network-proximal CTLA-4 vesicles for surface expression.
Molecular and cellular biology34(8)1486-99(2014 Apr)
Banton MC,Inder KL,Valk E,Rudd CE,Schneider H

The transmembrane region is responsible for targeting of adaptor protein LAX into "heavy rafts".
PloS one7(5)e36330(2012)
Hrdinka M,Otahal P,Horejsi V

Defining the membrane proteome of NK cells.
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)
Ghosh D,Lippert D,Krokhin O,Cortens JP,Wilkins JA

Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.
European journal of human genetics : EJHG17(12)1650-7(2009 Dec)
Ehret GB,O'Connor AA,Weder A,Cooper RS,Chakravarti A

Negative regulation of TCR signaling by linker for activation of X cells via phosphotyrosine-dependent and -independent mechanisms.
Journal of immunology (Baltimore, Md. : 1950)181(10)7055-61(2008 Nov)
Shapiro MJ,Nguyen CT,Aghajanian H,Zhang W,Shapiro VS

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LAX1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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