EPDR1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	EPDR1
Entrez Gene ID	54749
Full Name	ependymin related 1
Synonyms	EPDR,MERP-1,MERP1,UCC1
General protein information	Preferred Names ependymin related 1 Names mammalian ependymin-related protein 1 ependymin related protein 1 mammalian ependymin related protein 1 upregulated in colorectal cancer gene 1 protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7p14.1
Summary	The protein encoded by this gene is a type II transmembrane protein that is similar to two families of cell adhesion molecules, the protocadherins and ependymins. This protein may play a role in calcium-dependent cell adhesion. This protein is glycosylated, and the orthologous mouse protein is localized to the lysosome. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, Aug 2011].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001242948.1	NP_001229877.1	mammalian ependymin-related protein 1 isoform 3
NM_017549.5	NP_060019.2	mammalian ependymin-related protein 1 isoform 1 precursor
NM_001242946.1	NP_001229875.2	mammalian ependymin-related protein 1 isoform 2 precursor
NM_017549.4	NP_060019.2	mammalian ependymin-related protein 1 isoform 1 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	EPDR1	XP_005630990.1
Xenopus tropicalis (tropical clawed frog)	epdr1	XP_002939463.1
Bos taurus (cattle)	EPDR1	NP_001095758.1
Rattus norvegicus (Norway rat)	Epdr1	NP_001007626.1
Gallus gallus (chicken)	EPDR1	XP_418830.2
Homo sapiens (human)	EPDR1	NP_060019.2
Pan troglodytes (chimpanzee)	EPDR1	XP_003318311.1
Mus musculus (house mouse)	Epdr1	NP_598826.3
Danio rerio (zebrafish)	epdr1	NP_001002416.1

Gene Ontology
Bibliography

Related articles in PubMed

In silico RNA-seq and experimental analyses reveal the differential expression and splicing of EPDR1 and ZNF518B genes in relation to KRAS mutations in colorectal cancer cells.
Riffo-Campos ?L, Castillo J, Vallet-S?nchez A, Ayala G, Cervantes A, L?pez-Rodas G, Franco L
Oncology reports36(6)3627-3634(2016 Dec)

Dupuytren's disease susceptibility gene, EPDR1, is involved in myofibroblast contractility.
Staats KA, Wu T, Gan BS, O'Gorman DB, Ophoff RA
Journal of dermatological science83(2)131-7(2016 Aug)

Common variants of the EPDR1 gene and the risk of Dupuytren?s disease.
D?bniak T, ?yluk A, Puchalski P, Serrano-Fernandez P
Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V...45(5)253-7(2013 Oct)

Wnt signaling and Dupuytren's disease.
Dolmans GH, Werker PM, Hennies HC, Furniss D, Festen EA, Franke L, Becker K, van der Vlies P, Wolffenbuttel BH, Tinschert S, Toliat MR, Nothnagel M, Franke A, Klopp N, Wichmann HE, N?rnberg P, Giele H, Ophoff RA, Wijmenga C, , , ,
The New England journal of medicine365(4)307-17(2011 Jul)

Molecular evolution of the ependymin protein family: a necessary update.
Su?rez-Castillo EC, Garc?a-Arrar?s JE
BMC evolutionary biology723(2007 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

EPDR1 exhibits a pattern of isoform abundance dependent on KRAS G13D and G12D mutations.
Title: In silico RNA-seq and experimental analyses reveal the differential expression and splicing of EPDR1 and ZNF518B genes in relation to KRAS mutations in colorectal cancer cells.

Study results suggest functional involvement of EPDR1 in the etiology of Dupuytren's Disease.
Title: Dupuytren's disease susceptibility gene, EPDR1, is involved in myofibroblast contractility.

Results of this study suggest that EPDR1 gene can be added to a growing list of genes associated with Dupuytren's disease development.
Title: Common variants of the EPDR1 gene and the risk of Dupuytren?s disease.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Observational study of gene-disease association. (HuGE Navigator)
Title: Influence of multiple genetic polymorphisms on genitourinary morbidity after carbon ion radiotherapy for prostate cancer.

The following EPDR1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EPDR1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu10944	NM_001242946.1 Latest version!	Homo sapiens ependymin related 1 (EPDR1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu12009	NM_017549.5 Latest version!	Homo sapiens ependymin related 1 (EPDR1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu01373	NM_001242948.1 Latest version!	Homo sapiens ependymin related 1 (EPDR1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu12009	NM_017549.4	Homo sapiens ependymin related 1 (EPDR1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$202.30 $289.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

EPDR1 ( NM_001242946.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001229875.2 Homo sapiens ependymin related 1 (EPDR1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu10944
Clone ID Related Accession (Same CDS sequence)	NM_001242946.1
Accession Version	NM_001242946.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 273bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	mammalian ependymin-related protein 1 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY027862.2, DQ914439.1, AC018634.3 and BC000686.2. Transcript Variant: This variant (2) lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (2, also known as MERP1a) has a distinct and shorter C-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.170093.1, SRR1660807.237839.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: lack of evidence for use of upstream AUG ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCAGGAC GCGCTCCCCT CCGCACCGTC CCGGGCGCCC TGGGTGCCTG GCTGCTGGGC 
GGCCTCTGGG CCTGGACCCT GTGCGGCCTG TGCAGCCTGG GGGCGGTGGG AGCCCCGCGC 
CCGTGCCAGG CGCCGCAGCA GTGGGAGGGG CGCCAGGTTA TGTACCAGCA AAGTAGCGGG 
CGCAACAGCC GCGCCCTGCT CTCCTACGAC GGGCTCAACC AGCGCGTGCG GGTGCTGGAC 
GAGAGGAAGG CGCTGATCCC CTGCAAGAGA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001229875.2
CDS	380..652
Translation	MPGRAPLRTVPGALGAWLLGGLWAWTLCGLCSLGAVGAPRPCQAPQQWEGRQVMYQQSSGRNSRALLSYDGLNQRVRVLDERKALIPCKR

Target ORF information:

RefSeq Version	NM_001242946.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ependymin related 1 (EPDR1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001242946.1

ORF Insert Sequence:

ATGCCAGGAC GCGCTCCCCT CCGCACCGTC CCGGGCGCCC TGGGTGCCTG GCTGCTGGGC 
GGCCTCTGGG CCTGGACCCT GTGCGGCCTG TGCAGCCTGG GGGCGGTGGG AGCCCCGCGC 
CCGTGCCAGG CGCCGCAGCA GTGGGAGGGG CGCCAGGTTA TGTACCAGCA AAGTAGCGGG 
CGCAACAGCC GCGCCCTGCT CTCCTACGAC GGGCTCAACC AGCGCGTGCG GGTGCTGGAC 
GAGAGGAAGG CGCTGATCCC CTGCAAGAGA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EPDR1 ( NM_017549.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_060019.2 Homo sapiens ependymin related 1 (EPDR1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu12009
Clone ID Related Accession (Same CDS sequence)	NM_017549.5 , NM_017549.4
Accession Version	NM_017549.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 675bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Homo sapiens(human)
Product	mammalian ependymin-related protein 1 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY027862.2, DA938402.1, AC018634.3 and BC000686.2. On Nov 24, 2018 this sequence version replaced NM_017549.4. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY027862.2, SRR1803617.151218.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000199448.9/ ENSP00000199448.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCAGGAC GCGCTCCCCT CCGCACCGTC CCGGGCGCCC TGGGTGCCTG GCTGCTGGGC 
GGCCTCTGGG CCTGGACCCT GTGCGGCCTG TGCAGCCTGG GGGCGGTGGG AGCCCCGCGC 
CCGTGCCAGG CGCCGCAGCA GTGGGAGGGG CGCCAGGTTA TGTACCAGCA AAGTAGCGGG 
CGCAACAGCC GCGCCCTGCT CTCCTACGAC GGGCTCAACC AGCGCGTGCG GGTGCTGGAC 
GAGAGGAAGG CGCTGATCCC CTGCAAGAGA TTATTTGAAT ATATTTTGCT GTATAAGGAT 
GGAGTGATGT TTCAGATTGA CCAAGCCACC AAGCAGTGCT CAAAGATGAC CCTGACACAG 
CCCTGGGATC CTCTTGACAT TCCTCAAAAC TCCACCTTTG AAGACCAGTA CTCCATCGGG 
GGGCCTCAGG AGCAGATCAC CGTCCAGGAG TGGTCGGACA GAAAGTCAGC TAGATCCTAT 
GAAACCTGGA TTGGCATCTA TACAGTCAAG GATTGCTATC CTGTCCAGGA AACCTTTACC 
ATAAACTACA GTGTGATATT GTCTACGCGG TTTTTTGACA TCCAGCTGGG TATTAAAGAC 
CCCTCGGTGT TTACCCCTCC AAGCACGTGC CAGATGGCCC AACTGGAGAA GATGAGCGAA 
GACTGCTCCT GGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060019.2
CDS	301..975
Translation	MPGRAPLRTVPGALGAWLLGGLWAWTLCGLCSLGAVGAPRPCQAPQQWEGRQVMYQQSSGRNSRALLSYDGLNQRVRVLDERKALIPCKRLFEYILLYKDGVMFQIDQATKQCSKMTLTQPWDPLDIPQNSTFEDQYSIGGPQEQITVQEWSDRKSARSYETWIGIYTVKDCYPVQETFTINYSVILSTRFFDIQLGIKDPSVFTPPSTCQMAQLEKMSEDCSW

Target ORF information:

RefSeq Version	NM_017549.5
Organism	Homo sapiens(human)
Definition	Homo sapiens ependymin related 1 (EPDR1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017549.5

ORF Insert Sequence:

ATGCCAGGAC GCGCTCCCCT CCGCACCGTC CCGGGCGCCC TGGGTGCCTG GCTGCTGGGC 
GGCCTCTGGG CCTGGACCCT GTGCGGCCTG TGCAGCCTGG GGGCGGTGGG AGCCCCGCGC 
CCGTGCCAGG CGCCGCAGCA GTGGGAGGGG CGCCAGGTTA TGTACCAGCA AAGTAGCGGG 
CGCAACAGCC GCGCCCTGCT CTCCTACGAC GGGCTCAACC AGCGCGTGCG GGTGCTGGAC 
GAGAGGAAGG CGCTGATCCC CTGCAAGAGA TTATTTGAAT ATATTTTGCT GTATAAGGAT 
GGAGTGATGT TTCAGATTGA CCAAGCCACC AAGCAGTGCT CAAAGATGAC CCTGACACAG 
CCCTGGGATC CTCTTGACAT TCCTCAAAAC TCCACCTTTG AAGACCAGTA CTCCATCGGG 
GGGCCTCAGG AGCAGATCAC CGTCCAGGAG TGGTCGGACA GAAAGTCAGC TAGATCCTAT 
GAAACCTGGA TTGGCATCTA TACAGTCAAG GATTGCTATC CTGTCCAGGA AACCTTTACC 
ATAAACTACA GTGTGATATT GTCTACGCGG TTTTTTGACA TCCAGCTGGG TATTAAAGAC 
CCCTCGGTGT TTACCCCTCC AAGCACGTGC CAGATGGCCC AACTGGAGAA GATGAGCGAA 
GACTGCTCCT GGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EPDR1 ( NM_001242948.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001229877.1 Homo sapiens ependymin related 1 (EPDR1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu01373
Clone ID Related Accession (Same CDS sequence)	NM_001242948.1
Accession Version	NM_001242948.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 492bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-04
Organism	Homo sapiens(human)
Product	mammalian ependymin-related protein 1 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB167672.1, AC018634.3, AK309180.1, DB303790.1 and BC000686.2. Transcript Variant: This variant (3) uses an alternate 5' exon and thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (3) has a distinct and shorter N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DB167672.1, SRR1660807.259962.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTCCGGG ACTGGGAGGG GCGCTGCGCC CACCGAGGGC GGCCTGCTGG CGGGGGACTC 
AGTAACACCC AGCGAGGCGG TGGCAGATTA TTTGAATATA TTTTGCTGTA TAAGGATGGA 
GTGATGTTTC AGATTGACCA AGCCACCAAG CAGTGCTCAA AGATGACCCT GACACAGCCC 
TGGGATCCTC TTGACATTCC TCAAAACTCC ACCTTTGAAG ACCAGTACTC CATCGGGGGG 
CCTCAGGAGC AGATCACCGT CCAGGAGTGG TCGGACAGAA AGTCAGCTAG ATCCTATGAA 
ACCTGGATTG GCATCTATAC AGTCAAGGAT TGCTATCCTG TCCAGGAAAC CTTTACCATA 
AACTACAGTG TGATATTGTC TACGCGGTTT TTTGACATCC AGCTGGGTAT TAAAGACCCC 
TCGGTGTTTA CCCCTCCAAG CACGTGCCAG ATGGCCCAAC TGGAGAAGAT GAGCGAAGAC 
TGCTCCTGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001229877.1
CDS	48..539
Translation	MVRDWEGRCAHRGRPAGGGLSNTQRGGGRLFEYILLYKDGVMFQIDQATKQCSKMTLTQPWDPLDIPQNSTFEDQYSIGGPQEQITVQEWSDRKSARSYETWIGIYTVKDCYPVQETFTINYSVILSTRFFDIQLGIKDPSVFTPPSTCQMAQLEKMSEDCSW

Target ORF information:

RefSeq Version	NM_001242948.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ependymin related 1 (EPDR1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001242948.1

ORF Insert Sequence:

ATGGTCCGGG ACTGGGAGGG GCGCTGCGCC CACCGAGGGC GGCCTGCTGG CGGGGGACTC 
AGTAACACCC AGCGAGGCGG TGGCAGATTA TTTGAATATA TTTTGCTGTA TAAGGATGGA 
GTGATGTTTC AGATTGACCA AGCCACCAAG CAGTGCTCAA AGATGACCCT GACACAGCCC 
TGGGATCCTC TTGACATTCC TCAAAACTCC ACCTTTGAAG ACCAGTACTC CATCGGGGGG 
CCTCAGGAGC AGATCACCGT CCAGGAGTGG TCGGACAGAA AGTCAGCTAG ATCCTATGAA 
ACCTGGATTG GCATCTATAC AGTCAAGGAT TGCTATCCTG TCCAGGAAAC CTTTACCATA 
AACTACAGTG TGATATTGTC TACGCGGTTT TTTGACATCC AGCTGGGTAT TAAAGACCCC 
TCGGTGTTTA CCCCTCCAAG CACGTGCCAG ATGGCCCAAC TGGAGAAGAT GAGCGAAGAC 
TGCTCCTGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EPDR1 ( NM_017549.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_060019.2 Homo sapiens ependymin related 1 (EPDR1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu12009
Clone ID Related Accession (Same CDS sequence)	NM_017549.5 , NM_017549.4
Accession Version	NM_017549.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 675bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	mammalian ependymin-related protein 1 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY027862.2, DA938402.1, AC018634.3 and BC000686.2. On Aug 31, 2011 this sequence version replaced NM_017549.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY027862.2, SRR1803613.226021.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: lack of evidence for use of upstream AUG ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCAGGAC GCGCTCCCCT CCGCACCGTC CCGGGCGCCC TGGGTGCCTG GCTGCTGGGC 
GGCCTCTGGG CCTGGACCCT GTGCGGCCTG TGCAGCCTGG GGGCGGTGGG AGCCCCGCGC 
CCGTGCCAGG CGCCGCAGCA GTGGGAGGGG CGCCAGGTTA TGTACCAGCA AAGTAGCGGG 
CGCAACAGCC GCGCCCTGCT CTCCTACGAC GGGCTCAACC AGCGCGTGCG GGTGCTGGAC 
GAGAGGAAGG CGCTGATCCC CTGCAAGAGA TTATTTGAAT ATATTTTGCT GTATAAGGAT 
GGAGTGATGT TTCAGATTGA CCAAGCCACC AAGCAGTGCT CAAAGATGAC CCTGACACAG 
CCCTGGGATC CTCTTGACAT TCCTCAAAAC TCCACCTTTG AAGACCAGTA CTCCATCGGG 
GGGCCTCAGG AGCAGATCAC CGTCCAGGAG TGGTCGGACA GAAAGTCAGC TAGATCCTAT 
GAAACCTGGA TTGGCATCTA TACAGTCAAG GATTGCTATC CTGTCCAGGA AACCTTTACC 
ATAAACTACA GTGTGATATT GTCTACGCGG TTTTTTGACA TCCAGCTGGG TATTAAAGAC 
CCCTCGGTGT TTACCCCTCC AAGCACGTGC CAGATGGCCC AACTGGAGAA GATGAGCGAA 
GACTGCTCCT GGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060019.2
CDS	380..1054
Translation	MPGRAPLRTVPGALGAWLLGGLWAWTLCGLCSLGAVGAPRPCQAPQQWEGRQVMYQQSSGRNSRALLSYDGLNQRVRVLDERKALIPCKRLFEYILLYKDGVMFQIDQATKQCSKMTLTQPWDPLDIPQNSTFEDQYSIGGPQEQITVQEWSDRKSARSYETWIGIYTVKDCYPVQETFTINYSVILSTRFFDIQLGIKDPSVFTPPSTCQMAQLEKMSEDCSW

Target ORF information:

RefSeq Version	NM_017549.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ependymin related 1 (EPDR1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017549.4

ORF Insert Sequence:

ATGCCAGGAC GCGCTCCCCT CCGCACCGTC CCGGGCGCCC TGGGTGCCTG GCTGCTGGGC 
GGCCTCTGGG CCTGGACCCT GTGCGGCCTG TGCAGCCTGG GGGCGGTGGG AGCCCCGCGC 
CCGTGCCAGG CGCCGCAGCA GTGGGAGGGG CGCCAGGTTA TGTACCAGCA AAGTAGCGGG 
CGCAACAGCC GCGCCCTGCT CTCCTACGAC GGGCTCAACC AGCGCGTGCG GGTGCTGGAC 
GAGAGGAAGG CGCTGATCCC CTGCAAGAGA TTATTTGAAT ATATTTTGCT GTATAAGGAT 
GGAGTGATGT TTCAGATTGA CCAAGCCACC AAGCAGTGCT CAAAGATGAC CCTGACACAG 
CCCTGGGATC CTCTTGACAT TCCTCAAAAC TCCACCTTTG AAGACCAGTA CTCCATCGGG 
GGGCCTCAGG AGCAGATCAC CGTCCAGGAG TGGTCGGACA GAAAGTCAGC TAGATCCTAT 
GAAACCTGGA TTGGCATCTA TACAGTCAAG GATTGCTATC CTGTCCAGGA AACCTTTACC 
ATAAACTACA GTGTGATATT GTCTACGCGG TTTTTTGACA TCCAGCTGGG TATTAAAGAC 
CCCTCGGTGT TTACCCCTCC AAGCACGTGC CAGATGGCCC AACTGGAGAA GATGAGCGAA 
GACTGCTCCT GGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

In silico RNA-seq and experimental analyses reveal the differential expression and splicing of EPDR1 and ZNF518B genes in relation to KRAS mutations in colorectal cancer cells.
Oncology reports36(6)3627-3634(2016 Dec)
Riffo-Campos ?L,Castillo J,Vallet-S?nchez A,Ayala G,Cervantes A,L?pez-Rodas G,Franco L

Dupuytren's disease susceptibility gene, EPDR1, is involved in myofibroblast contractility.
Journal of dermatological science83(2)131-7(2016 Aug)
Staats KA,Wu T,Gan BS,O'Gorman DB,Ophoff RA

Common variants of the EPDR1 gene and the risk of Dupuytren?s disease.
Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V...45(5)253-7(2013 Oct)
D?bniak T,?yluk A,Puchalski P,Serrano-Fernandez P

Wnt signaling and Dupuytren's disease.
The New England journal of medicine365(4)307-17(2011 Jul)
Dolmans GH,Werker PM,Hennies HC,Furniss D,Festen EA,Franke L,Becker K,van der Vlies P,Wolffenbuttel BH,Tinschert S,Toliat MR,Nothnagel M,Franke A,Klopp N,Wichmann HE,N?rnberg P,Giele H,Ophoff RA,Wijmenga C,,,,

Molecular evolution of the ependymin protein family: a necessary update.
BMC evolutionary biology723(2007 Feb)
Su?rez-Castillo EC,Garc?a-Arrar?s JE

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EPDR1 cDNA ORF clone, Homo sapiens(human)

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