FEV cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FEV
Entrez Gene ID	54738
Full Name	FEV, ETS transcription factor
Synonyms	HSRNAFEV,PET-1
General protein information	Preferred Names FEV, ETS transcription factor Names protein FEV FEV (ETS oncogene family) PC12 ETS domain-containing transcription factor 1 fifth Ewing variant protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q35
Summary	This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome translocations. [provided by RefSeq, Jul 2008].
Disorder MIM:	607150

mRNA and Protein(s)

mRNA	Protein	Name
NM_017521.2	NP_059991.1	protein FEV
NM_017521.3	NP_059991.1	protein FEV

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	FEV	XP_003309530.1
	FEV	XP_001095962.1
Bos taurus (cattle)	FEV	NP_001179532.1
Danio rerio (zebrafish)	fev	NP_001074126.1
Xenopus tropicalis (tropical clawed frog)	fev	XP_002934005.1
Rattus norvegicus (Norway rat)	Fev	NP_653354.2
Homo sapiens (human)	FEV	NP_059991.1
Mus musculus (house mouse)	Fev	NP_694751.1
Gallus gallus (chicken)	LOC100857480	XP_003641694.1

Gene Ontology
Bibliography

Related articles in PubMed

Association of genetic variations in the serotonin and dopamine systems with aggressive behavior in the Chinese adolescent population: Single- and multiple-risk genetic variants.
Chang H, Yan Q, Tang L, Huang J, Ma Y, Ye X, Wu C, Wu L, Yu Y
Journal of affective disorders225374-380(2018 Jan)

Expression of the fetal hematopoiesis regulator FEV indicates leukemias of prenatal origin.
Liu TH, Tang YJ, Huang Y, Wang L, Guo XL, Mi JQ, Liu LG, Zhu H, Zhang Y, Chen L, Liu X, Zhang LH, Ye QJ, Li BS, Tang JY, Ford A, Enver T, Liu F, Chen GQ, Hong DL
Leukemia31(5)1079-1086(2017 May)

Association of 25-Hydroxyvitamin D status and genetic variation in the vitamin D metabolic pathway with FEV1 in the Framingham Heart Study.
Hansen JG, Gao W, Dupuis J, O'Connor GT, Tang W, Kowgier M, Sood A, Gharib SA, Palmer LJ, Fornage M, Heckbert SR, Psaty BM, Booth SL, , Cassano PA
Respiratory research1681(2015 Jul)

Convergent effects of mouse Pet-1 deletion and human PET-1 variation on amygdala fear and threat processing.
Wellman CL, Camp M, Jones VM, MacPherson KP, Ihne J, Fitzgerald P, Maroun M, Drabant E, Bogdan R, Hariri AR, Holmes A
Experimental neurology250260-9(2013 Dec)

Fev regulates hematopoietic stem cell development via ERK signaling.
Wang L, Liu T, Xu L, Gao Y, Wei Y, Duan C, Chen GQ, Lin S, Patient R, Zhang B, Hong D, Liu F
Blood122(3)367-75(2013 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

identified FEV is unique to fetal HSCs and stably expressed in leukemic cells of prenatal origin
Title: Expression of the fetal hematopoiesis regulator FEV indicates leukemias of prenatal origin.

Genetic variation in FEV1 was associated with serum 25-Hydroxyvitamin D status.
Title: Association of 25-Hydroxyvitamin D status and genetic variation in the vitamin D metabolic pathway with FEV1 in the Framingham Heart Study.

novel evidence for the role of Pet-1 in human amygdala threat processing extends literature demonstrating the influence of genetic variation in the serotonin system on emotional regulation
Title: Convergent effects of mouse Pet-1 deletion and human PET-1 variation on amygdala fear and threat processing.

Fev-ERK signaling is essential for hemogenic endothelium-based hematopoietic stem cell development.
Title: Fev regulates hematopoietic stem cell development via ERK signaling.

Observational study of gene-disease association. (HuGE Navigator)
Title: The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.

The following FEV gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FEV cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19395	NM_017521.3 Latest version!	Homo sapiens FEV transcription factor, ETS family member (FEV), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
View Old Accession Versions >>
OHu19395	NM_017521.2	Homo sapiens FEV transcription factor, ETS family member (FEV), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FEV ( NM_017521.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_059991.1 Homo sapiens FEV transcription factor, ETS family member (FEV), mRNA.

Price & Availability↑

CloneID	OHu19395
Clone ID Related Accession (Same CDS sequence)	NM_017521.2 , NM_017521.3
Accession Version	NM_017521.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 717bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	protein FEV
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Y08976.1 and BC023511.2. This sequence is a reference standard in the RefSeqGene project. On Dec 10, 2004 this sequence version replaced NM_017521.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y08976.1, BI438572.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGACAGA GCGGCGCCTC CCAGCCCCTG CTGATCAACA TGTACCTGCC AGATCCCGTC 
GGAGACGGTC TCTTCAAGGA CGGGAAGAAC CCGAGCTGGG GGCCGCTGAG CCCCGCGGTT 
CAGAAAGGCA GCGGACAGAT CCAGCTGTGG CAGTTTCTGC TGGAGCTGCT GGCTGACCGC 
GCGAACGCCG GCTGCATCGC GTGGGAGGGC GGTCACGGCG AGTTCAAGCT CACGGACCCG 
GACGAGGTGG CGCGGCGGTG GGGCGAGCGC AAGAGCAAGC CCAACATGAA CTACGACAAG 
CTGAGCCGCG CCCTGCGCTA CTACTACGAC AAGAACATCA TGAGCAAGGT GCATGGCAAG 
CGCTACGCCT ACCGCTTCGA CTTCCAGGGC CTGGCGCAGG CCTGCCAGCC GCCGCCCGCG 
CACGCTCATG CCGCCGCCGC AGCTGCTGCC GCCGCCGCGG CCGCCCAGGA CGGCGCGCTC 
TACAAGCTGC CCGCCGGCCT CGCCCCGCTG CCCTTCCCCG GCCTCTCCAA ACTCAACCTC 
ATGGCCGCCT CGGCCGGGGT CGCGCCCGCC GGCTTCTCCT ACTGGCCGGG CCCGGGCCCC 
GCCGCCACCG CTGCCGCCGC CACCGCCGCG CTCTACCCCA GTCCCAGCTT GCAGCCCCCG 
CCCGGGCCCT TCGGGGCCGT GGCCGCAGCC TCGCACTTGG GGGGCCATTA CCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_059991.1
CDS	583..1299
Translation	MRQSGASQPLLINMYLPDPVGDGLFKDGKNPSWGPLSPAVQKGSGQIQLWQFLLELLADRANAGCIAWEGGHGEFKLTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMSKVHGKRYAYRFDFQGLAQACQPPPAHAHAAAAAAAAAAAAQDGALYKLPAGLAPLPFPGLSKLNLMAASAGVAPAGFSYWPGPGPAATAAAATAALYPSPSLQPPPGPFGAVAAASHLGGHYH

Target ORF information:

RefSeq Version	NM_017521.2
Organism	Homo sapiens(human)
Definition	Homo sapiens FEV transcription factor, ETS family member (FEV), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017521.2

ORF Insert Sequence:

ATGAGACAGA GCGGCGCCTC CCAGCCCCTG CTGATCAACA TGTACCTGCC AGATCCCGTC 
GGAGACGGTC TCTTCAAGGA CGGGAAGAAC CCGAGCTGGG GGCCGCTGAG CCCCGCGGTT 
CAGAAAGGCA GCGGACAGAT CCAGCTGTGG CAGTTTCTGC TGGAGCTGCT GGCTGACCGC 
GCGAACGCCG GCTGCATCGC GTGGGAGGGC GGTCACGGCG AGTTCAAGCT CACGGACCCG 
GACGAGGTGG CGCGGCGGTG GGGCGAGCGC AAGAGCAAGC CCAACATGAA CTACGACAAG 
CTGAGCCGCG CCCTGCGCTA CTACTACGAC AAGAACATCA TGAGCAAGGT GCATGGCAAG 
CGCTACGCCT ACCGCTTCGA CTTCCAGGGC CTGGCGCAGG CCTGCCAGCC GCCGCCCGCG 
CACGCTCATG CCGCCGCCGC AGCTGCTGCC GCCGCCGCGG CCGCCCAGGA CGGCGCGCTC 
TACAAGCTGC CCGCCGGCCT CGCCCCGCTG CCCTTCCCCG GCCTCTCCAA ACTCAACCTC 
ATGGCCGCCT CGGCCGGGGT CGCGCCCGCC GGCTTCTCCT ACTGGCCGGG CCCGGGCCCC 
GCCGCCACCG CTGCCGCCGC CACCGCCGCG CTCTACCCCA GTCCCAGCTT GCAGCCCCCG 
CCCGGGCCCT TCGGGGCCGT GGCCGCAGCC TCGCACTTGG GGGGCCATTA CCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FEV ( NM_017521.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_059991.1 Homo sapiens FEV transcription factor, ETS family member (FEV), mRNA.

Price & Availability↑

CloneID	OHu19395
Clone ID Related Accession (Same CDS sequence)	NM_017521.2 , NM_017521.3
Accession Version	NM_017521.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 717bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-14
Organism	Homo sapiens(human)
Product	protein FEV
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC097468.3. This sequence is a reference standard in the RefSeqGene project. On Jul 23, 2019 this sequence version replaced NM_017521.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC023511.2, Y08976.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGACAGA GCGGCGCCTC CCAGCCCCTG CTGATCAACA TGTACCTGCC AGATCCCGTC 
GGAGACGGTC TCTTCAAGGA CGGGAAGAAC CCGAGCTGGG GGCCGCTGAG CCCCGCGGTT 
CAGAAAGGCA GCGGACAGAT CCAGCTGTGG CAGTTTCTGC TGGAGCTGCT GGCTGACCGC 
GCGAACGCCG GCTGCATCGC GTGGGAGGGC GGTCACGGCG AGTTCAAGCT CACGGACCCG 
GACGAGGTGG CGCGGCGGTG GGGCGAGCGC AAGAGCAAGC CCAACATGAA CTACGACAAG 
CTGAGCCGCG CCCTGCGCTA CTACTACGAC AAGAACATCA TGAGCAAGGT GCATGGCAAG 
CGCTACGCCT ACCGCTTCGA CTTCCAGGGC CTGGCGCAGG CCTGCCAGCC GCCGCCCGCG 
CACGCTCATG CCGCCGCCGC AGCTGCTGCC GCCGCCGCGG CCGCCCAGGA CGGCGCGCTC 
TACAAGCTGC CCGCCGGCCT CGCCCCGCTG CCCTTCCCCG GCCTCTCCAA ACTCAACCTC 
ATGGCCGCCT CGGCCGGGGT CGCGCCCGCC GGCTTCTCCT ACTGGCCGGG CCCGGGCCCC 
GCCGCCACCG CTGCCGCCGC CACCGCCGCG CTCTACCCCA GTCCCAGCTT GCAGCCCCCG 
CCCGGGCCCT TCGGGGCCGT GGCCGCAGCC TCGCACTTGG GGGGCCATTA CCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_059991.1
CDS	110..826
Translation	MRQSGASQPLLINMYLPDPVGDGLFKDGKNPSWGPLSPAVQKGSGQIQLWQFLLELLADRANAGCIAWEGGHGEFKLTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMSKVHGKRYAYRFDFQGLAQACQPPPAHAHAAAAAAAAAAAAQDGALYKLPAGLAPLPFPGLSKLNLMAASAGVAPAGFSYWPGPGPAATAAAATAALYPSPSLQPPPGPFGAVAAASHLGGHYH

Target ORF information:

RefSeq Version	NM_017521.3
Organism	Homo sapiens(human)
Definition	Homo sapiens FEV transcription factor, ETS family member (FEV), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017521.3

ORF Insert Sequence:

ATGAGACAGA GCGGCGCCTC CCAGCCCCTG CTGATCAACA TGTACCTGCC AGATCCCGTC 
GGAGACGGTC TCTTCAAGGA CGGGAAGAAC CCGAGCTGGG GGCCGCTGAG CCCCGCGGTT 
CAGAAAGGCA GCGGACAGAT CCAGCTGTGG CAGTTTCTGC TGGAGCTGCT GGCTGACCGC 
GCGAACGCCG GCTGCATCGC GTGGGAGGGC GGTCACGGCG AGTTCAAGCT CACGGACCCG 
GACGAGGTGG CGCGGCGGTG GGGCGAGCGC AAGAGCAAGC CCAACATGAA CTACGACAAG 
CTGAGCCGCG CCCTGCGCTA CTACTACGAC AAGAACATCA TGAGCAAGGT GCATGGCAAG 
CGCTACGCCT ACCGCTTCGA CTTCCAGGGC CTGGCGCAGG CCTGCCAGCC GCCGCCCGCG 
CACGCTCATG CCGCCGCCGC AGCTGCTGCC GCCGCCGCGG CCGCCCAGGA CGGCGCGCTC 
TACAAGCTGC CCGCCGGCCT CGCCCCGCTG CCCTTCCCCG GCCTCTCCAA ACTCAACCTC 
ATGGCCGCCT CGGCCGGGGT CGCGCCCGCC GGCTTCTCCT ACTGGCCGGG CCCGGGCCCC 
GCCGCCACCG CTGCCGCCGC CACCGCCGCG CTCTACCCCA GTCCCAGCTT GCAGCCCCCG 
CCCGGGCCCT TCGGGGCCGT GGCCGCAGCC TCGCACTTGG GGGGCCATTA CCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Association of genetic variations in the serotonin and dopamine systems with aggressive behavior in the Chinese adolescent population: Single- and multiple-risk genetic variants.
Journal of affective disorders225374-380(2018 Jan)
Chang H,Yan Q,Tang L,Huang J,Ma Y,Ye X,Wu C,Wu L,Yu Y

Expression of the fetal hematopoiesis regulator FEV indicates leukemias of prenatal origin.
Leukemia31(5)1079-1086(2017 May)
Liu TH,Tang YJ,Huang Y,Wang L,Guo XL,Mi JQ,Liu LG,Zhu H,Zhang Y,Chen L,Liu X,Zhang LH,Ye QJ,Li BS,Tang JY,Ford A,Enver T,Liu F,Chen GQ,Hong DL

Association of 25-Hydroxyvitamin D status and genetic variation in the vitamin D metabolic pathway with FEV1 in the Framingham Heart Study.
Respiratory research1681(2015 Jul)
Hansen JG,Gao W,Dupuis J,O'Connor GT,Tang W,Kowgier M,Sood A,Gharib SA,Palmer LJ,Fornage M,Heckbert SR,Psaty BM,Booth SL,,Cassano PA

Convergent effects of mouse Pet-1 deletion and human PET-1 variation on amygdala fear and threat processing.
Experimental neurology250260-9(2013 Dec)
Wellman CL,Camp M,Jones VM,MacPherson KP,Ihne J,Fitzgerald P,Maroun M,Drabant E,Bogdan R,Hariri AR,Holmes A

Fev regulates hematopoietic stem cell development via ERK signaling.
Blood122(3)367-75(2013 Jul)
Wang L,Liu T,Xu L,Gao Y,Wei Y,Duan C,Chen GQ,Lin S,Patient R,Zhang B,Hong D,Liu F

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

FEV cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報