PPBP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PPBP
Entrez Gene ID	5473
Full Name	pro-platelet basic protein
Synonyms	B-TG1,Beta-TG,CTAP-III,CTAP3,CTAPIII,CXCL7,LA-PF4,LDGF,MDGF,NAP-2,PBP,SCYB7,TC1,TC2,TGB,TGB1,THBGB,THBGB1
General protein information	Preferred Names pro-platelet basic protein Names platelet basic protein C-X-C motif chemokine 7 CXC chemokine ligand 7 beta-thromboglobulin chemokine (C-X-C motif) ligand 7 connective tissue-activating peptide III leukocyte-derived growth factor low-affinity platelet factor IV macrophage-derived growth factor neutrophil-activating peptide 2 small inducible cytokine B7 small inducible cytokine subfamily B, member 7 thrombocidin 1 thrombocidin 2 thromboglobulin, beta-1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q13.3
Summary	The protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. The protein also is an antimicrobial protein with bactericidal and antifungal activity. [provided by RefSeq, Nov 2014].
Disorder MIM:	121010

mRNA and Protein(s)

mRNA	Protein	Name
NM_002704.3	NP_002695.1	platelet basic protein preproprotein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PPBP	XP_001155921.1
Homo sapiens (human)	PPBP	NP_002695.1

Gene Ontology
Bibliography

Related articles in PubMed

Identification of candidate serum biomarkers of childhood-onset growth hormone deficiency using SWATH-MS and feature selection.
Ortea I, Ruiz-S?nchez I, Ca?ete R, Caballero-Villarraso J, Ca?ete MD
Journal of proteomics(2018 Jan)

CTAPIII/CXCL7: a novel biomarker for early diagnosis of lung cancer.
Du Q, Li E, Liu Y, Xie W, Huang C, Song J, Zhang W, Zheng Y, Wang H, Wang Q
Cancer medicine(2018 Jan)

Expression level of CXCL7 in peripheral blood cells is a potential biomarker for the diagnosis of renal cell carcinoma.
Kinouchi T, Uemura M, Wang C, Ishizuya Y, Yamamoto Y, Hayashi T, Matsuzaki K, Nakata W, Yoshida T, Jingushi K, Kawashima A, Ujike T, Nagahara A, Fujita K, Imamura R, Ueda Y, Kitae K, Tsujikawa K, Nonomura N
Cancer science108(12)2495-2502(2017 Dec)

?-Thromboglobulin and incident cardiovascular disease risk: The Atherosclerosis Risk in Communities study.
Kubota Y, Alonso A, Folsom AR
Thrombosis research155116-120(2017 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest that aberrant CXCL7 expression in peripheral blood cells is induced by renal cell carcinoma cells and may serve as a novel biomarker in the diagnosis of renal cell carcinoma .
Title: Expression level of CXCL7 in peripheral blood cells is a potential biomarker for the diagnosis of renal cell carcinoma.

Two haplotype blocks, one upstream to the coding region of UGT2A1 (rs146712414, P = 9.1 x 10(-5); odds ratio [OR], 1.34; 95% confidence interval [CI], 1.16-1.56) and one downstream of the genes PF4/PPBP/CXCL5 (rs1595009, P = 1.3 x 10(-4); OR, 1.32; 95% CI, 1.15-1.52), were associated with AgP.
Title: The PF4/PPBP/CXCL5 Gene Cluster Is Associated with Periodontitis.

NMR and modeling studies indicated that glycosaminoglycans (GAG) heparin binding to the heterodimer is distinctly different from the CXC chemokine ligand 7 (CXCL7) monomer.
Title: Chemokine CXCL7 Heterodimers: Structural Insights, CXCR2 Receptor Function, and Glycosaminoglycan Interactions.

CXCL7 plays a promoting role in regulating the growth and metastasis of cholangiocarcinoma.
Title: CXCL7 promotes proliferation and invasion of cholangiocarcinoma cells.

Cby's C-terminal domain alone binds to TC-1 with significantly greater affinity compared to full-length Cby, implying that target binding of the coiled-coil domain is affected by the flanking disordered regions.
Title: Conformational characterization of the intrinsically disordered protein Chibby: Interplay between structural elements in target recognition.

The following PPBP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PPBP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu01842	NM_002704.3 Latest version!	Homo sapiens pro-platelet basic protein (PPBP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PPBP ( NM_002704.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002695.1 Homo sapiens pro-platelet basic protein (PPBP), mRNA.

Price & Availability↑

CloneID	OHu01842
Clone ID Related Accession (Same CDS sequence)	NM_002704.3
Accession Version	NM_002704.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 387bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-15
Organism	Homo sapiens(human)
Product	platelet basic protein preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA419455.1 and AC097709.3. On May 15, 2010 this sequence version replaced NM_002704.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA419455.1, ERR279839.8839.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2149004, SAMN01820689 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000296028.4/ ENSP00000296028.3 Protein has antimicrobial activity :: PMID: 10877842 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGCCTCA GACTTGATAC CACCCCTTCC TGTAACAGTG CGAGACCACT TCATGCCTTG 
CAGGTGCTGC TGCTTCTGTC ATTGCTGCTG ACTGCTCTGG CTTCCTCCAC CAAAGGACAA 
ACTAAGAGAA ACTTGGCGAA AGGCAAAGAG GAAAGTCTAG ACAGTGACTT GTATGCTGAA 
CTCCGCTGCA TGTGTATAAA GACAACCTCT GGAATTCATC CCAAAAACAT CCAAAGTTTG 
GAAGTGATCG GGAAAGGAAC CCATTGCAAC CAAGTCGAAG TGATAGCCAC ACTGAAGGAT 
GGGAGGAAAA TCTGCCTGGA CCCAGATGCT CCCAGAATCA AGAAAATTGT ACAGAAAAAA 
TTGGCAGGTG ATGAATCTGC TGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002695.1
CDS	88..474
Translation	MSLRLDTTPSCNSARPLHALQVLLLLSLLLTALASSTKGQTKRNLAKGKEESLDSDLYAELRCMCIKTTSGIHPKNIQSLEVIGKGTHCNQVEVIATLKDGRKICLDPDAPRIKKIVQKKLAGDESAD

Target ORF information:

RefSeq Version	NM_002704.3
Organism	Homo sapiens(human)
Definition	Homo sapiens pro-platelet basic protein (PPBP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002704.3

ORF Insert Sequence:

ATGAGCCTCA GACTTGATAC CACCCCTTCC TGTAACAGTG CGAGACCACT TCATGCCTTG 
CAGGTGCTGC TGCTTCTGTC ATTGCTGCTG ACTGCTCTGG CTTCCTCCAC CAAAGGACAA 
ACTAAGAGAA ACTTGGCGAA AGGCAAAGAG GAAAGTCTAG ACAGTGACTT GTATGCTGAA 
CTCCGCTGCA TGTGTATAAA GACAACCTCT GGAATTCATC CCAAAAACAT CCAAAGTTTG 
GAAGTGATCG GGAAAGGAAC CCATTGCAAC CAAGTCGAAG TGATAGCCAC ACTGAAGGAT 
GGGAGGAAAA TCTGCCTGGA CCCAGATGCT CCCAGAATCA AGAAAATTGT ACAGAAAAAA 
TTGGCAGGTG ATGAATCTGC TGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of candidate serum biomarkers of childhood-onset growth hormone deficiency using SWATH-MS and feature selection.
Journal of proteomics(2018 Jan)
Ortea I,Ruiz-S?nchez I,Ca?ete R,Caballero-Villarraso J,Ca?ete MD

CTAPIII/CXCL7: a novel biomarker for early diagnosis of lung cancer.
Cancer medicine(2018 Jan)
Du Q,Li E,Liu Y,Xie W,Huang C,Song J,Zhang W,Zheng Y,Wang H,Wang Q

Expression level of CXCL7 in peripheral blood cells is a potential biomarker for the diagnosis of renal cell carcinoma.
Cancer science108(12)2495-2502(2017 Dec)
Kinouchi T,Uemura M,Wang C,Ishizuya Y,Yamamoto Y,Hayashi T,Matsuzaki K,Nakata W,Yoshida T,Jingushi K,Kawashima A,Ujike T,Nagahara A,Fujita K,Imamura R,Ueda Y,Kitae K,Tsujikawa K,Nonomura N

?-Thromboglobulin and incident cardiovascular disease risk: The Atherosclerosis Risk in Communities study.
Thrombosis research155116-120(2017 Jul)
Kubota Y,Alonso A,Folsom AR

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PPBP cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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