MRPS21 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MRPS21
Entrez Gene ID	54460
Full Name	mitochondrial ribosomal protein S21
Synonyms	MDS016,MRP-S21,RPMS21
General protein information	Preferred Names mitochondrial ribosomal protein S21 Names 28S ribosomal protein S21, mitochondrial S21mt mitochondrial 28S ribosomal protein S21 mitochondrial small ribosomal subunit protein bS21m
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q21.2
Summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S21P family. Pseudogenes corresponding to this gene are found on chromosomes 1p, 1q, 9p, 10p, 10q, 16q, and 17q. Available sequence data analyses identified splice variants that differ in the 5' UTR; both transcripts encode the same protein. [provided by RefSeq, Jul 2008].
Disorder MIM:	611984

mRNA and Protein(s)

mRNA	Protein	Name
NM_018997.3	NP_061870.1	28S ribosomal protein S21, mitochondrial
NM_031901.5	NP_114107.1	28S ribosomal protein S21, mitochondrial

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Mrps21	NP_001119566.1
Gallus gallus (chicken)	MRPS21	NP_001264896.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009152	XP_319913.2
Homo sapiens (human)	MRPS21	NP_061870.1
Xenopus tropicalis (tropical clawed frog)	mrps21	NP_001016340.1
	MRPS21	XP_001083064.1
Drosophila melanogaster (fruit fly)	mRpS21	NP_001262535.1
Pan troglodytes (chimpanzee)	MRPS21	XP_001168584.1
Canis lupus familiaris (dog)	MRPS21	XP_003639676.1
Mus musculus (house mouse)	Mrps21	NP_510964.1
Bos taurus (cattle)	MRPS21	NP_001106778.1
Danio rerio (zebrafish)	mrps21	NP_001153310.2

Gene Ontology
Bibliography

Related articles in PubMed

A genome-wide association study of behavioral disinhibition.
McGue M, Zhang Y, Miller MB, Basu S, Vrieze S, Hicks B, Malone S, Oetting WS, Iacono WG
Behavior genetics43(5)363-73(2013 Sep)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)

Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.
Zhang Z, Gerstein M
Genomics81(5)468-80(2003 May)

The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.
Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T
Genomics77(1-2)65-70(2001 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The following MRPS21 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MRPS21 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu10989	NM_018997.3 Latest version!	Homo sapiens mitochondrial ribosomal protein S21 (MRPS21), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu10989	NM_031901.5 Latest version!	Homo sapiens mitochondrial ribosomal protein S21 (MRPS21), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MRPS21 ( NM_018997.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_061870.1 Homo sapiens mitochondrial ribosomal protein S21 (MRPS21), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu10989
Clone ID Related Accession (Same CDS sequence)	NM_018997.3 , NM_031901.5
Accession Version	NM_018997.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 264bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	28S ribosomal protein S21, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC242988.1 and U79258.1. On Jul 19, 2013 this sequence version replaced NM_018997.2. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 both encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: U79258.1, SRR1803611.24501.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##

ATGGCAAAAC ATCTGAAGTT CATCGCCAGG ACTGTGATGG TACAGGAAGG GAACGTGGAA 
AGCGCATACA GGACCCTAAA CAGAATCCTC ACTATGGATG GGCTCATTGA GGACATTAAG 
CATCGGCGGT ATTATGAGAA GCCATGCCGC CGGCGACAGA GGGAAAGCTA TGAAAGGTGC 
CGGCGGATCT ACAACATGGA AATGGCTCGC AAGATCAACT TCTTGATGCG AAAGAATCGG 
GCAGATCCGT GGCAGGGCTG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061870.1
CDS	526..789
Translation	MAKHLKFIARTVMVQEGNVESAYRTLNRILTMDGLIEDIKHRRYYEKPCRRRQRESYERCRRIYNMEMARKINFLMRKNRADPWQGC

Target ORF information:

RefSeq Version	NM_018997.3
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein S21 (MRPS21), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018997.3

ORF Insert Sequence:

ATGGCAAAAC ATCTGAAGTT CATCGCCAGG ACTGTGATGG TACAGGAAGG GAACGTGGAA 
AGCGCATACA GGACCCTAAA CAGAATCCTC ACTATGGATG GGCTCATTGA GGACATTAAG 
CATCGGCGGT ATTATGAGAA GCCATGCCGC CGGCGACAGA GGGAAAGCTA TGAAAGGTGC 
CGGCGGATCT ACAACATGGA AATGGCTCGC AAGATCAACT TCTTGATGCG AAAGAATCGG 
GCAGATCCGT GGCAGGGCTG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRPS21 ( NM_031901.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_114107.1 Homo sapiens mitochondrial ribosomal protein S21 (MRPS21), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu10989
Clone ID Related Accession (Same CDS sequence)	NM_018997.3 , NM_031901.5
Accession Version	NM_031901.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 264bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	28S ribosomal protein S21, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY161691.1, AK289467.1, AC242988.1 and U79258.1. On Jul 19, 2013 this sequence version replaced NM_031901.4. Transcript Variant: This variant (1) is the predominant transcript. Variants 1 and 2 both encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.315241.1, SRR1803611.390156.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCAAAAC ATCTGAAGTT CATCGCCAGG ACTGTGATGG TACAGGAAGG GAACGTGGAA 
AGCGCATACA GGACCCTAAA CAGAATCCTC ACTATGGATG GGCTCATTGA GGACATTAAG 
CATCGGCGGT ATTATGAGAA GCCATGCCGC CGGCGACAGA GGGAAAGCTA TGAAAGGTGC 
CGGCGGATCT ACAACATGGA AATGGCTCGC AAGATCAACT TCTTGATGCG AAAGAATCGG 
GCAGATCCGT GGCAGGGCTG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_114107.1
CDS	90..353
Translation	MAKHLKFIARTVMVQEGNVESAYRTLNRILTMDGLIEDIKHRRYYEKPCRRRQRESYERCRRIYNMEMARKINFLMRKNRADPWQGC

Target ORF information:

RefSeq Version	NM_031901.5
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein S21 (MRPS21), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031901.5

ORF Insert Sequence:

ATGGCAAAAC ATCTGAAGTT CATCGCCAGG ACTGTGATGG TACAGGAAGG GAACGTGGAA 
AGCGCATACA GGACCCTAAA CAGAATCCTC ACTATGGATG GGCTCATTGA GGACATTAAG 
CATCGGCGGT ATTATGAGAA GCCATGCCGC CGGCGACAGA GGGAAAGCTA TGAAAGGTGC 
CGGCGGATCT ACAACATGGA AATGGCTCGC AAGATCAACT TCTTGATGCG AAAGAATCGG 
GCAGATCCGT GGCAGGGCTG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A genome-wide association study of behavioral disinhibition.
Behavior genetics43(5)363-73(2013 Sep)
McGue M,Zhang Y,Miller MB,Basu S,Vrieze S,Hicks B,Malone S,Oetting WS,Iacono WG

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ

Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.
Genomics81(5)468-80(2003 May)
Zhang Z,Gerstein M

The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.
Genomics77(1-2)65-70(2001 Sep)
Kenmochi N,Suzuki T,Uechi T,Magoori M,Kuniba M,Higa S,Watanabe K,Tanaka T

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MRPS21 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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