SEPTIN5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SEPTIN5
Entrez Gene ID	5413
Full Name	septin 5
Synonyms	CDCREL,CDCREL-1,CDCREL1,H5,HCDCREL-1,PNUTL1
General protein information	Preferred Names septin 5 Names septin-5 cell division control related protein 1 peanut-like 1 platelet glycoprotein Ib beta chain
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q11.21
Summary	This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced. [provided by RefSeq, Dec 2010].
Disorder MIM:	602724

mRNA and Protein(s)

mRNA	Protein	Name
NM_001009939.2	NP_001009939.1	septin-5 isoform 2
NM_002688.5	NP_002679.2	septin-5 isoform 1
NM_002688.6	NP_002679.2	septin-5 isoform 1
NM_001009939.3	NP_001009939.1	septin-5 isoform 2

Pathways from BioSystems

Homologies

	SEPT5	XP_001105256.1
Xenopus tropicalis (tropical clawed frog)	sept5	NP_001096453.1
Pan troglodytes (chimpanzee)	SEPT5	XP_001166286.1
Gallus gallus (chicken)	SEP-05	NP_001025825.2
Canis lupus familiaris (dog)	SEPT5	XP_005636644.1
Mus musculus (house mouse)	Sept5	NP_998779.2
Homo sapiens (human)	SEPT5	NP_002679.2
Bos taurus (cattle)	SEPT5	NP_001069839.1
Rattus norvegicus (Norway rat)	Sept5	NP_446383.3

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.
Corominas R, Yang X, Lin GN, Kang S, Shen Y, Ghamsari L, Broly M, Rodriguez M, Tam S, Trigg SA, Fan C, Yi S, Tasan M, Lemmens I, Kuang X, Zhao N, Malhotra D, Michaelson JJ, Vacic V, Calderwood MA, Roth FP, Tavernier J, Horvath S, Salehi-Ashtiani K, Korkin D, Sebat J, Hill DE, Hao T, Vidal M, Iakoucheva LM
Nature communications53650(2014 Apr)

GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association.
Renter?a ME, Coolen MW, Statham AL, Choi RS, Qu W, Campbell MJ, Smith S, Henders AK, Montgomery GW, Clark SJ, Martin NG, Medland SE
Twin research and human genetics : the official journal of the International Society for Twin Studies16(4)767-81(2013 Aug)

Synaptic vesicle trafficking and Parkinson's disease.
Esposito G, Ana Clara F, Verstreken P
Developmental neurobiology72(1)134-44(2012 Jan)

HSP70 and constitutively active HSF1 mediate protection against CDCrel-1-mediated toxicity.
Jung AE, Fitzsimons HL, Bland RJ, During MJ, Young D
Molecular therapy : the journal of the American Society of Gene Therapy16(6)1048-55(2008 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

HSP70 and constitutively active HSF1 mediate protection against CDCrel-1-mediated toxicity
Title: HSP70 and constitutively active HSF1 mediate protection against CDCrel-1-mediated toxicity.

Our finding suggests a role for members of the septin family in the development of proliferative retinal membranes.
Title: Septin expression in proliferative retinal membranes.

the high expression levels of PNUTL1 in human pancreatic endocrine cells that suggests a similar role of this protein in islet cells to that demonstrated in neuronal tissues, and warrants further functional studies of this protein.
Title: Peanut-like 1 (septin 5) gene expression in normal and neoplastic human endocrine pancreas.

We studied the assembly of three human septins, SEPT4, SEPT5 and SEPT8, with each other (heterotypic) and with themselves (homotypic) using a yeast two-hybrid system.
Title: Human septin-septin interactions as a prerequisite for targeting septin complexes in the cytosol.

CDCrel-1 overexpression exerts dopamine-dependent neurotoxicity and may contribute to the development of autosomal-recessive juvenile parkinsonism
Title: Dopamine-dependent neurodegeneration in rats induced by viral vector-mediated overexpression of the parkin target protein, CDCrel-1.

The following SEPTIN5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SEPTIN5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22254	NM_002688.6 Latest version!	Homo sapiens septin 5 (SEPTIN5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu23167	NM_001009939.3 Latest version!	Homo sapiens septin 5 (SEPTIN5), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu22254	NM_002688.5	Homo sapiens septin 5 (SEPT5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu23167	NM_001009939.2	Homo sapiens septin 5 (SEPT5), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SEPTIN5 ( NM_002688.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002679.2 Homo sapiens septin 5 (SEPT5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22254
Clone ID Related Accession (Same CDS sequence)	NM_002688.5 , NM_002688.6
Accession Version	NM_002688.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1110bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	septin-5 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC000093.5, BC025261.1 and BQ448147.1. On Dec 2, 2010 this sequence version replaced NM_002688.4. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC025261.1, U74628.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCACAG GCCTGCGGTA CAAGAGCAAG CTGGCGACCC CAGAGGACAA GCAGGACATT 
GACAAGCAGT ACGTGGGCTT CGCCACACTG CCCAACCAGG TGCACCGCAA GTCGGTGAAG 
AAAGGCTTTG ACTTCACACT CATGGTGGCT GGTGAGTCAG GCCTGGGGAA GTCCACACTG 
GTCCACAGCC TCTTCCTGAC AGACTTGTAC AAGGACCGGA AGCTGCTCAG TGCTGAGGAG 
CGCATCAGCC AGACGGTAGA GATTCTAAAA CACACGGTGG ACATTGAGGA GAAGGGAGTC 
AAGCTGAAGC TCACCATCGT GGACACGCCG GGATTCGGGG ACGCTGTCAA CAACACCGAG 
TGCTGGAAGC CCATCACCGA CTATGTGGAC CAGCAGTTTG AGCAGTACTT CCGTGATGAG 
AGCGGCCTCA ACCGAAAGAA CATCCAAGAC AACCGAGTGC ACTGCTGCCT ATACTTCATC 
TCCCCCTTCG GGCATGGGCT GCGGCCAGTG GATGTGGGTT TCATGAAGGC ATTGCATGAG 
AAGGTCAACA TCGTGCCTCT CATCGCCAAA GCTGACTGTC TTGTCCCCAG TGAGATCCGG 
AAGCTGAAGG AGCGGATCCG GGAGGAGATT GACAAGTTTG GGATCCATGT ATACCAGTTC 
CCTGAGTGTG ACTCGGACGA GGATGAGGAC TTCAAGCAGC AGGACCGGGA ACTGAAGGAG 
AGCGCGCCCT TCGCCGTTAT AGGCAGCAAC ACGGTGGTGG AGGCCAAGGG GCAGCGGGTC 
CGGGGCCGAC TGTACCCCTG GGGGATCGTG GAGGTGGAGA ACCAGGCGCA TTGCGACTTC 
GTGAAGCTGC GCAACATGCT CATCCGCACG CATATGCACG ACCTCAAGGA CGTGACGTGC 
GACGTGCACT ACGAGAACTA CCGCGCGCAC TGCATCCAGC AGATGACCAG CAAACTGACC 
CAGGACAGCC GCATGGAGAG CCCCATCCCG ATCCTGCCGC TGCCCACCCC GGACGCCGAG 
ACTGAGAAGC TTATCAGGAT GAAGGATGAG GAACTGAGGC GCATGCAGGA GATGCTGCAG 
AGGATGAAGC AGCAGATGCA GGACCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002679.2
CDS	126..1235
Translation	MSTGLRYKSKLATPEDKQDIDKQYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVHSLFLTDLYKDRKLLSAEERISQTVEILKHTVDIEEKGVKLKLTIVDTPGFGDAVNNTECWKPITDYVDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPVDVGFMKALHEKVNIVPLIAKADCLVPSEIRKLKERIREEIDKFGIHVYQFPECDSDEDEDFKQQDRELKESAPFAVIGSNTVVEAKGQRVRGRLYPWGIVEVENQAHCDFVKLRNMLIRTHMHDLKDVTCDVHYENYRAHCIQQMTSKLTQDSRMESPIPILPLPTPDAETEKLIRMKDEELRRMQEMLQRMKQQMQDQ

Target ORF information:

RefSeq Version	NM_002688.5
Organism	Homo sapiens(human)
Definition	Homo sapiens septin 5 (SEPT5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002688.5

ORF Insert Sequence:

ATGAGCACAG GCCTGCGGTA CAAGAGCAAG CTGGCGACCC CAGAGGACAA GCAGGACATT 
GACAAGCAGT ACGTGGGCTT CGCCACACTG CCCAACCAGG TGCACCGCAA GTCGGTGAAG 
AAAGGCTTTG ACTTCACACT CATGGTGGCT GGTGAGTCAG GCCTGGGGAA GTCCACACTG 
GTCCACAGCC TCTTCCTGAC AGACTTGTAC AAGGACCGGA AGCTGCTCAG TGCTGAGGAG 
CGCATCAGCC AGACGGTAGA GATTCTAAAA CACACGGTGG ACATTGAGGA GAAGGGAGTC 
AAGCTGAAGC TCACCATCGT GGACACGCCG GGATTCGGGG ACGCTGTCAA CAACACCGAG 
TGCTGGAAGC CCATCACCGA CTATGTGGAC CAGCAGTTTG AGCAGTACTT CCGTGATGAG 
AGCGGCCTCA ACCGAAAGAA CATCCAAGAC AACCGAGTGC ACTGCTGCCT ATACTTCATC 
TCCCCCTTCG GGCATGGGCT GCGGCCAGTG GATGTGGGTT TCATGAAGGC ATTGCATGAG 
AAGGTCAACA TCGTGCCTCT CATCGCCAAA GCTGACTGTC TTGTCCCCAG TGAGATCCGG 
AAGCTGAAGG AGCGGATCCG GGAGGAGATT GACAAGTTTG GGATCCATGT ATACCAGTTC 
CCTGAGTGTG ACTCGGACGA GGATGAGGAC TTCAAGCAGC AGGACCGGGA ACTGAAGGAG 
AGCGCGCCCT TCGCCGTTAT AGGCAGCAAC ACGGTGGTGG AGGCCAAGGG GCAGCGGGTC 
CGGGGCCGAC TGTACCCCTG GGGGATCGTG GAGGTGGAGA ACCAGGCGCA TTGCGACTTC 
GTGAAGCTGC GCAACATGCT CATCCGCACG CATATGCACG ACCTCAAGGA CGTGACGTGC 
GACGTGCACT ACGAGAACTA CCGCGCGCAC TGCATCCAGC AGATGACCAG CAAACTGACC 
CAGGACAGCC GCATGGAGAG CCCCATCCCG ATCCTGCCGC TGCCCACCCC GGACGCCGAG 
ACTGAGAAGC TTATCAGGAT GAAGGATGAG GAACTGAGGC GCATGCAGGA GATGCTGCAG 
AGGATGAAGC AGCAGATGCA GGACCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SEPTIN5 ( NM_002688.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_002679.2 Homo sapiens septin 5 (SEPTIN5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22254
Clone ID Related Accession (Same CDS sequence)	NM_002688.5 , NM_002688.6
Accession Version	NM_002688.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1110bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-23
Organism	Homo sapiens(human)
Product	septin-5 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC025261.1. On Nov 22, 2018 this sequence version replaced NM_002688.5. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC025261.1, U74628.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000455784.7/ ENSP00000391311.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGCACAG GCCTGCGGTA CAAGAGCAAG CTGGCGACCC CAGAGGACAA GCAGGACATT 
GACAAGCAGT ACGTGGGCTT CGCCACACTG CCCAACCAGG TGCACCGCAA GTCGGTGAAG 
AAAGGCTTTG ACTTCACACT CATGGTGGCT GGTGAGTCAG GCCTGGGGAA GTCCACACTG 
GTCCACAGCC TCTTCCTGAC AGACTTGTAC AAGGACCGGA AGCTGCTCAG TGCTGAGGAG 
CGCATCAGCC AGACGGTAGA GATTCTAAAA CACACGGTGG ACATTGAGGA GAAGGGAGTC 
AAGCTGAAGC TCACCATCGT GGACACGCCG GGATTCGGGG ACGCTGTCAA CAACACCGAG 
TGCTGGAAGC CCATCACCGA CTATGTGGAC CAGCAGTTTG AGCAGTACTT CCGTGATGAG 
AGCGGCCTCA ACCGAAAGAA CATCCAAGAC AACCGAGTGC ACTGCTGCCT ATACTTCATC 
TCCCCCTTCG GGCATGGGCT GCGGCCAGTG GATGTGGGTT TCATGAAGGC ATTGCATGAG 
AAGGTCAACA TCGTGCCTCT CATCGCCAAA GCTGACTGTC TTGTCCCCAG TGAGATCCGG 
AAGCTGAAGG AGCGGATCCG GGAGGAGATT GACAAGTTTG GGATCCATGT ATACCAGTTC 
CCTGAGTGTG ACTCGGACGA GGATGAGGAC TTCAAGCAGC AGGACCGGGA ACTGAAGGAG 
AGCGCGCCCT TCGCCGTTAT AGGCAGCAAC ACGGTGGTGG AGGCCAAGGG GCAGCGGGTC 
CGGGGCCGAC TGTACCCCTG GGGGATCGTG GAGGTGGAGA ACCAGGCGCA TTGCGACTTC 
GTGAAGCTGC GCAACATGCT CATCCGCACG CATATGCACG ACCTCAAGGA CGTGACGTGC 
GACGTGCACT ACGAGAACTA CCGCGCGCAC TGCATCCAGC AGATGACCAG CAAACTGACC 
CAGGACAGCC GCATGGAGAG CCCCATCCCG ATCCTGCCGC TGCCCACCCC GGACGCCGAG 
ACTGAGAAGC TTATCAGGAT GAAGGATGAG GAACTGAGGC GCATGCAGGA GATGCTGCAG 
AGGATGAAGC AGCAGATGCA GGACCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002679.2
CDS	87..1196
Translation	MSTGLRYKSKLATPEDKQDIDKQYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVHSLFLTDLYKDRKLLSAEERISQTVEILKHTVDIEEKGVKLKLTIVDTPGFGDAVNNTECWKPITDYVDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPVDVGFMKALHEKVNIVPLIAKADCLVPSEIRKLKERIREEIDKFGIHVYQFPECDSDEDEDFKQQDRELKESAPFAVIGSNTVVEAKGQRVRGRLYPWGIVEVENQAHCDFVKLRNMLIRTHMHDLKDVTCDVHYENYRAHCIQQMTSKLTQDSRMESPIPILPLPTPDAETEKLIRMKDEELRRMQEMLQRMKQQMQDQ

Target ORF information:

RefSeq Version	NM_002688.6
Organism	Homo sapiens(human)
Definition	Homo sapiens septin 5 (SEPTIN5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002688.6

ORF Insert Sequence:

ATGAGCACAG GCCTGCGGTA CAAGAGCAAG CTGGCGACCC CAGAGGACAA GCAGGACATT 
GACAAGCAGT ACGTGGGCTT CGCCACACTG CCCAACCAGG TGCACCGCAA GTCGGTGAAG 
AAAGGCTTTG ACTTCACACT CATGGTGGCT GGTGAGTCAG GCCTGGGGAA GTCCACACTG 
GTCCACAGCC TCTTCCTGAC AGACTTGTAC AAGGACCGGA AGCTGCTCAG TGCTGAGGAG 
CGCATCAGCC AGACGGTAGA GATTCTAAAA CACACGGTGG ACATTGAGGA GAAGGGAGTC 
AAGCTGAAGC TCACCATCGT GGACACGCCG GGATTCGGGG ACGCTGTCAA CAACACCGAG 
TGCTGGAAGC CCATCACCGA CTATGTGGAC CAGCAGTTTG AGCAGTACTT CCGTGATGAG 
AGCGGCCTCA ACCGAAAGAA CATCCAAGAC AACCGAGTGC ACTGCTGCCT ATACTTCATC 
TCCCCCTTCG GGCATGGGCT GCGGCCAGTG GATGTGGGTT TCATGAAGGC ATTGCATGAG 
AAGGTCAACA TCGTGCCTCT CATCGCCAAA GCTGACTGTC TTGTCCCCAG TGAGATCCGG 
AAGCTGAAGG AGCGGATCCG GGAGGAGATT GACAAGTTTG GGATCCATGT ATACCAGTTC 
CCTGAGTGTG ACTCGGACGA GGATGAGGAC TTCAAGCAGC AGGACCGGGA ACTGAAGGAG 
AGCGCGCCCT TCGCCGTTAT AGGCAGCAAC ACGGTGGTGG AGGCCAAGGG GCAGCGGGTC 
CGGGGCCGAC TGTACCCCTG GGGGATCGTG GAGGTGGAGA ACCAGGCGCA TTGCGACTTC 
GTGAAGCTGC GCAACATGCT CATCCGCACG CATATGCACG ACCTCAAGGA CGTGACGTGC 
GACGTGCACT ACGAGAACTA CCGCGCGCAC TGCATCCAGC AGATGACCAG CAAACTGACC 
CAGGACAGCC GCATGGAGAG CCCCATCCCG ATCCTGCCGC TGCCCACCCC GGACGCCGAG 
ACTGAGAAGC TTATCAGGAT GAAGGATGAG GAACTGAGGC GCATGCAGGA GATGCTGCAG 
AGGATGAAGC AGCAGATGCA GGACCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SEPTIN5 ( NM_001009939.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001009939.1 Homo sapiens septin 5 (SEPT5), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu23167
Clone ID Related Accession (Same CDS sequence)	NM_001009939.2 , NM_001009939.3
Accession Version	NM_001009939.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1041bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-24
Organism	Homo sapiens(human)
Product	septin-5 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI601927.1, AK056273.1, AC000093.5 and BQ448147.1. On Dec 2, 2010 this sequence version replaced NM_001009939.1. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform 2 has a shorter and distinct N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK056273.1, SRR1803614.236440.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACTCGC TGGCAGCGCC CCAGGACCGC CTGGTGGAGC AGCTGCTGTC GCCGCGGACC 
CAGGCCCAGA GGCGGCTCAA GGACATTGAC AAGCAGTACG TGGGCTTCGC CACACTGCCC 
AACCAGGTGC ACCGCAAGTC GGTGAAGAAA GGCTTTGACT TCACACTCAT GGTGGCTGGT 
GAGTCAGGCC TGGGGAAGTC CACACTGGTC CACAGCCTCT TCCTGACAGA CTTGTACAAG 
GACCGGAAGC TGCTCAGTGC TGAGGAGCGC ATCAGCCAGA CGGTAGAGAT TCTAAAACAC 
ACGGTGGACA TTGAGGAGAA GGGAGTCAAG CTGAAGCTCA CCATCGTGGA CACGCCGGGA 
TTCGGGGACG CTGTCAACAA CACCGAGTGC TGGAAGCCCA TCACCGACTA TGTGGACCAG 
CAGTTTGAGC AGTACTTCCG TGATGAGAGC GGCCTCAACC GAAAGAACAT CCAAGACAAC 
CGAGTGCACT GCTGCCTATA CTTCATCTCC CCCTTCGGGC ATGGGCTGCG GCCAGTGGAT 
GTGGGTTTCA TGAAGGCATT GCATGAGAAG GTCAACATCG TGCCTCTCAT CGCCAAAGCT 
GACTGTCTTG TCCCCAGTGA GATCCGGAAG CTGAAGGAGC GGATCCGGGA GGAGATTGAC 
AAGTTTGGGA TCCATGTATA CCAGTTCCCT GAGTGTGACT CGGACGAGGA TGAGGACTTC 
AAGCAGCAGG ACCGGGAACT GAAGGAGAGC GCGCCCTTCG CCGTTATAGG CAGCAACACG 
GTGGTGGAGG CCAAGGGGCA GCGGGTCCGG GGCCGACTGT ACCCCTGGGG GATCGTGGAG 
GGCGCATTGC GACTTCGTGA AGCTGCGCAA CATGCTCATC CGCACGCATA TGCACGACCT 
CAAGGACGTG ACGTGCGACG TGCACTACGA GAACTACCGC GCGCACTGCA TCCAGCAGAT 
GACCAGCAAA CTGACCCAGG ACAGCCGCAT GGAGAGCCCC ATCCCGATCC TGCCGCTGCC 
CACCCCGGAC GCCGAGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001009939.1
CDS	304..1344
Translation	MDSLAAPQDRLVEQLLSPRTQAQRRLKDIDKQYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVHSLFLTDLYKDRKLLSAEERISQTVEILKHTVDIEEKGVKLKLTIVDTPGFGDAVNNTECWKPITDYVDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPVDVGFMKALHEKVNIVPLIAKADCLVPSEIRKLKERIREEIDKFGIHVYQFPECDSDEDEDFKQQDRELKESAPFAVIGSNTVVEAKGQRVRGRLYPWGIVEGALRLREAAQHAHPHAYARPQGRDVRRALRELPRALHPADDQQTDPGQPHGEPHPDPAAAHPGRRD

Target ORF information:

RefSeq Version	NM_001009939.2
Organism	Homo sapiens(human)
Definition	Homo sapiens septin 5 (SEPT5), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001009939.2

ORF Insert Sequence:

ATGGACTCGC TGGCAGCGCC CCAGGACCGC CTGGTGGAGC AGCTGCTGTC GCCGCGGACC 
CAGGCCCAGA GGCGGCTCAA GGACATTGAC AAGCAGTACG TGGGCTTCGC CACACTGCCC 
AACCAGGTGC ACCGCAAGTC GGTGAAGAAA GGCTTTGACT TCACACTCAT GGTGGCTGGT 
GAGTCAGGCC TGGGGAAGTC CACACTGGTC CACAGCCTCT TCCTGACAGA CTTGTACAAG 
GACCGGAAGC TGCTCAGTGC TGAGGAGCGC ATCAGCCAGA CGGTAGAGAT TCTAAAACAC 
ACGGTGGACA TTGAGGAGAA GGGAGTCAAG CTGAAGCTCA CCATCGTGGA CACGCCGGGA 
TTCGGGGACG CTGTCAACAA CACCGAGTGC TGGAAGCCCA TCACCGACTA TGTGGACCAG 
CAGTTTGAGC AGTACTTCCG TGATGAGAGC GGCCTCAACC GAAAGAACAT CCAAGACAAC 
CGAGTGCACT GCTGCCTATA CTTCATCTCC CCCTTCGGGC ATGGGCTGCG GCCAGTGGAT 
GTGGGTTTCA TGAAGGCATT GCATGAGAAG GTCAACATCG TGCCTCTCAT CGCCAAAGCT 
GACTGTCTTG TCCCCAGTGA GATCCGGAAG CTGAAGGAGC GGATCCGGGA GGAGATTGAC 
AAGTTTGGGA TCCATGTATA CCAGTTCCCT GAGTGTGACT CGGACGAGGA TGAGGACTTC 
AAGCAGCAGG ACCGGGAACT GAAGGAGAGC GCGCCCTTCG CCGTTATAGG CAGCAACACG 
GTGGTGGAGG CCAAGGGGCA GCGGGTCCGG GGCCGACTGT ACCCCTGGGG GATCGTGGAG 
GGCGCATTGC GACTTCGTGA AGCTGCGCAA CATGCTCATC CGCACGCATA TGCACGACCT 
CAAGGACGTG ACGTGCGACG TGCACTACGA GAACTACCGC GCGCACTGCA TCCAGCAGAT 
GACCAGCAAA CTGACCCAGG ACAGCCGCAT GGAGAGCCCC ATCCCGATCC TGCCGCTGCC 
CACCCCGGAC GCCGAGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SEPTIN5 ( NM_001009939.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001009939.1 Homo sapiens septin 5 (SEPTIN5), transcript variant 2, mRNA.

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CloneID	OHu23167
Clone ID Related Accession (Same CDS sequence)	NM_001009939.2 , NM_001009939.3
Accession Version	NM_001009939.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1041bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	septin-5 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI601927.1, AK056273.1 and AC000093.5. On May 31, 2019 this sequence version replaced NM_001009939.2. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform 2 has a shorter and distinct N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK056273.1, SRR1803614.236440.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACTCGC TGGCAGCGCC CCAGGACCGC CTGGTGGAGC AGCTGCTGTC GCCGCGGACC 
CAGGCCCAGA GGCGGCTCAA GGACATTGAC AAGCAGTACG TGGGCTTCGC CACACTGCCC 
AACCAGGTGC ACCGCAAGTC GGTGAAGAAA GGCTTTGACT TCACACTCAT GGTGGCTGGT 
GAGTCAGGCC TGGGGAAGTC CACACTGGTC CACAGCCTCT TCCTGACAGA CTTGTACAAG 
GACCGGAAGC TGCTCAGTGC TGAGGAGCGC ATCAGCCAGA CGGTAGAGAT TCTAAAACAC 
ACGGTGGACA TTGAGGAGAA GGGAGTCAAG CTGAAGCTCA CCATCGTGGA CACGCCGGGA 
TTCGGGGACG CTGTCAACAA CACCGAGTGC TGGAAGCCCA TCACCGACTA TGTGGACCAG 
CAGTTTGAGC AGTACTTCCG TGATGAGAGC GGCCTCAACC GAAAGAACAT CCAAGACAAC 
CGAGTGCACT GCTGCCTATA CTTCATCTCC CCCTTCGGGC ATGGGCTGCG GCCAGTGGAT 
GTGGGTTTCA TGAAGGCATT GCATGAGAAG GTCAACATCG TGCCTCTCAT CGCCAAAGCT 
GACTGTCTTG TCCCCAGTGA GATCCGGAAG CTGAAGGAGC GGATCCGGGA GGAGATTGAC 
AAGTTTGGGA TCCATGTATA CCAGTTCCCT GAGTGTGACT CGGACGAGGA TGAGGACTTC 
AAGCAGCAGG ACCGGGAACT GAAGGAGAGC GCGCCCTTCG CCGTTATAGG CAGCAACACG 
GTGGTGGAGG CCAAGGGGCA GCGGGTCCGG GGCCGACTGT ACCCCTGGGG GATCGTGGAG 
GGCGCATTGC GACTTCGTGA AGCTGCGCAA CATGCTCATC CGCACGCATA TGCACGACCT 
CAAGGACGTG ACGTGCGACG TGCACTACGA GAACTACCGC GCGCACTGCA TCCAGCAGAT 
GACCAGCAAA CTGACCCAGG ACAGCCGCAT GGAGAGCCCC ATCCCGATCC TGCCGCTGCC 
CACCCCGGAC GCCGAGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001009939.1
CDS	296..1336
Translation	MDSLAAPQDRLVEQLLSPRTQAQRRLKDIDKQYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVHSLFLTDLYKDRKLLSAEERISQTVEILKHTVDIEEKGVKLKLTIVDTPGFGDAVNNTECWKPITDYVDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPVDVGFMKALHEKVNIVPLIAKADCLVPSEIRKLKERIREEIDKFGIHVYQFPECDSDEDEDFKQQDRELKESAPFAVIGSNTVVEAKGQRVRGRLYPWGIVEGALRLREAAQHAHPHAYARPQGRDVRRALRELPRALHPADDQQTDPGQPHGEPHPDPAAAHPGRRD

Target ORF information:

RefSeq Version	NM_001009939.3
Organism	Homo sapiens(human)
Definition	Homo sapiens septin 5 (SEPTIN5), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001009939.3

ORF Insert Sequence:

ATGGACTCGC TGGCAGCGCC CCAGGACCGC CTGGTGGAGC AGCTGCTGTC GCCGCGGACC 
CAGGCCCAGA GGCGGCTCAA GGACATTGAC AAGCAGTACG TGGGCTTCGC CACACTGCCC 
AACCAGGTGC ACCGCAAGTC GGTGAAGAAA GGCTTTGACT TCACACTCAT GGTGGCTGGT 
GAGTCAGGCC TGGGGAAGTC CACACTGGTC CACAGCCTCT TCCTGACAGA CTTGTACAAG 
GACCGGAAGC TGCTCAGTGC TGAGGAGCGC ATCAGCCAGA CGGTAGAGAT TCTAAAACAC 
ACGGTGGACA TTGAGGAGAA GGGAGTCAAG CTGAAGCTCA CCATCGTGGA CACGCCGGGA 
TTCGGGGACG CTGTCAACAA CACCGAGTGC TGGAAGCCCA TCACCGACTA TGTGGACCAG 
CAGTTTGAGC AGTACTTCCG TGATGAGAGC GGCCTCAACC GAAAGAACAT CCAAGACAAC 
CGAGTGCACT GCTGCCTATA CTTCATCTCC CCCTTCGGGC ATGGGCTGCG GCCAGTGGAT 
GTGGGTTTCA TGAAGGCATT GCATGAGAAG GTCAACATCG TGCCTCTCAT CGCCAAAGCT 
GACTGTCTTG TCCCCAGTGA GATCCGGAAG CTGAAGGAGC GGATCCGGGA GGAGATTGAC 
AAGTTTGGGA TCCATGTATA CCAGTTCCCT GAGTGTGACT CGGACGAGGA TGAGGACTTC 
AAGCAGCAGG ACCGGGAACT GAAGGAGAGC GCGCCCTTCG CCGTTATAGG CAGCAACACG 
GTGGTGGAGG CCAAGGGGCA GCGGGTCCGG GGCCGACTGT ACCCCTGGGG GATCGTGGAG 
GGCGCATTGC GACTTCGTGA AGCTGCGCAA CATGCTCATC CGCACGCATA TGCACGACCT 
CAAGGACGTG ACGTGCGACG TGCACTACGA GAACTACCGC GCGCACTGCA TCCAGCAGAT 
GACCAGCAAA CTGACCCAGG ACAGCCGCAT GGAGAGCCCC ATCCCGATCC TGCCGCTGCC 
CACCCCGGAC GCCGAGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.
Nature communications53650(2014 Apr)
Corominas R,Yang X,Lin GN,Kang S,Shen Y,Ghamsari L,Broly M,Rodriguez M,Tam S,Trigg SA,Fan C,Yi S,Tasan M,Lemmens I,Kuang X,Zhao N,Malhotra D,Michaelson JJ,Vacic V,Calderwood MA,Roth FP,Tavernier J,Horvath S,Salehi-Ashtiani K,Korkin D,Sebat J,Hill DE,Hao T,Vidal M,Iakoucheva LM

GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association.
Twin research and human genetics : the official journal of the International Society for Twin Studies16(4)767-81(2013 Aug)
Renter?a ME,Coolen MW,Statham AL,Choi RS,Qu W,Campbell MJ,Smith S,Henders AK,Montgomery GW,Clark SJ,Martin NG,Medland SE

Synaptic vesicle trafficking and Parkinson's disease.
Developmental neurobiology72(1)134-44(2012 Jan)
Esposito G,Ana Clara F,Verstreken P

HSP70 and constitutively active HSF1 mediate protection against CDCrel-1-mediated toxicity.
Molecular therapy : the journal of the American Society of Gene Therapy16(6)1048-55(2008 Jun)
Jung AE,Fitzsimons HL,Bland RJ,During MJ,Young D

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SEPTIN5 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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