CHRAC1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CHRAC1
Entrez Gene ID	54108
Full Name	chromatin accessibility complex 1
Synonyms	CHARC1,CHARC15,CHRAC-1,CHRAC-15,CHRAC15,YCL1
General protein information	Preferred Names chromatin accessibility complex 1 Names chromatin accessibility complex protein 1 DNA polymerase epsilon subunit p15 chromatin accessibility complex 15 kDa protein histone-fold protein CHRAC15
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8q24.3
Summary	CHRAC1 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004].
Disorder MIM:	607268

mRNA and Protein(s)

mRNA	Protein	Name
NM_017444.6	NP_059140.1	chromatin accessibility complex protein 1
NM_017444.5	NP_059140.1	chromatin accessibility complex protein 1

Pathways from BioSystems

Homologies

	CHRAC1	XP_001090712.1
Bos taurus (cattle)	CHRAC1	NP_001068946.1
Rattus norvegicus (Norway rat)	Chrac1	NP_001128352.1
Xenopus tropicalis (tropical clawed frog)	chrac1	NP_001015967.1
Pan troglodytes (chimpanzee)	CHRAC1	XP_003954488.1
Danio rerio (zebrafish)	chrac1	NP_001013311.1
Homo sapiens (human)	CHRAC1	NP_059140.1
Mus musculus (house mouse)	Chrac1	NP_444298.1
Gallus gallus (chicken)	CHRAC1	XP_003640917.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007481	XP_308392.4

Gene Ontology
Bibliography

Related articles in PubMed

A siRNA screen identifies RAD21, EIF3H, CHRAC1 and TANC2 as driver genes within the 8q23, 8q24.3 and 17q23 amplicons in breast cancer with effects on cell growth, survival and transformation.
Mahmood SF, Gruel N, Chapeaublanc E, Lescure A, Jones T, Reyal F, Vincent-Salomon A, Raynal V, Pierron G, Perez F, Camonis J, Del Nery E, Delattre O, Radvanyi F, Bernard-Pierrot I
Carcinogenesis35(3)670-82(2014 Mar)

Next-generation sequencing to generate interactome datasets.
Yu H, Tardivo L, Tam S, Weiner E, Gebreab F, Fan C, Svrzikapa N, Hirozane-Kishikawa T, Rietman E, Yang X, Sahalie J, Salehi-Ashtiani K, Hao T, Cusick ME, Hill DE, Roth FP, Braun P, Vidal M
Nature methods8(6)478-80(2011 Jun)

An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin.
Collins N, Poot RA, Kukimoto I, Garc?a-Jim?nez C, Dellaire G, Varga-Weisz PD
Nature genetics32(4)627-32(2002 Dec)

Cloning and characterization of the histone-fold proteins YBL1 and YCL1.
Bolognese F, Imbriano C, Caretti G, Mantovani R
Nucleic acids research28(19)3830-8(2000 Oct)

HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins.
Poot RA, Dellaire G, H?lsmann BB, Grimaldi MA, Corona DF, Becker PB, Bickmore WA, Varga-Weisz PD
The EMBO journal19(13)3377-87(2000 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

-RAD21 and EIF3H, both on chromosome 8q23, CHRAC1 on chromosome 8q24.3 and TANC2 on chromosome 17q23-were confirmed to be driver genes regulating the proliferation/survival of clonogenic breast cancer cells
Title: A siRNA screen identifies RAD21, EIF3H, CHRAC1 and TANC2 as driver genes within the 8q23, 8q24.3 and 17q23 amplicons in breast cancer with effects on cell growth, survival and transformation.

The following CHRAC1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CHRAC1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu07666	NM_017444.6 Latest version!	Homo sapiens chromatin accessibility complex subunit 1 (CHRAC1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu07666	NM_017444.5	Homo sapiens chromatin accessibility complex 1 (CHRAC1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CHRAC1 ( NM_017444.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_059140.1 Homo sapiens chromatin accessibility complex subunit 1 (CHRAC1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu07666
Clone ID Related Accession (Same CDS sequence)	NM_017444.6 , NM_017444.5
Accession Version	NM_017444.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 396bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-07
Organism	Homo sapiens(human)
Product	chromatin accessibility complex protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK023537.1 and AC107375.5. On Nov 23, 2018 this sequence version replaced NM_017444.5. Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK023537.1, SRR1803616.80491.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000220913.10/ ENSP00000220913.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGACG TGGTCGTGGG TAAAGACAAG GGCGGGGAGC AGCGGCTCAT CTCGCTGCCT 
CTATCCCGCA TCCGGGTCAT CATGAAGAGC TCCCCCGAGG TGTCCAGCAT CAACCAGGAG 
GCGTTGGTGC TCACGGCCAA GGCCACGGAG CTCTTTGTTC AATGCCTAGC CACCTATTCC 
TACAGACACG GCAGTGGAAA GGAAAAGAAA GTACTGACTT ACAGTGATTT AGCAAACACT 
GCACAGCAAT CAGAAACTTT TCAGTTTCTT GCAGATATAT TACCAAAGAA GATTTTAGCT 
AGTAAATACC TGAAAATGCT TAAAGAGGAA AAGAGGGAAG AAGATGAGGA GAATGACAAT 
GATAATGAAA GTGACCATGA TGAAGCTGAC TCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_059140.1
CDS	179..574
Translation	MADVVVGKDKGGEQRLISLPLSRIRVIMKSSPEVSSINQEALVLTAKATELFVQCLATYSYRHGSGKEKKVLTYSDLANTAQQSETFQFLADILPKKILASKYLKMLKEEKREEDEENDNDNESDHDEADS

Target ORF information:

RefSeq Version	NM_017444.6
Organism	Homo sapiens(human)
Definition	Homo sapiens chromatin accessibility complex subunit 1 (CHRAC1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017444.6

ORF Insert Sequence:

ATGGCGGACG TGGTCGTGGG TAAAGACAAG GGCGGGGAGC AGCGGCTCAT CTCGCTGCCT 
CTATCCCGCA TCCGGGTCAT CATGAAGAGC TCCCCCGAGG TGTCCAGCAT CAACCAGGAG 
GCGTTGGTGC TCACGGCCAA GGCCACGGAG CTCTTTGTTC AATGCCTAGC CACCTATTCC 
TACAGACACG GCAGTGGAAA GGAAAAGAAA GTACTGACTT ACAGTGATTT AGCAAACACT 
GCACAGCAAT CAGAAACTTT TCAGTTTCTT GCAGATATAT TACCAAAGAA GATTTTAGCT 
AGTAAATACC TGAAAATGCT TAAAGAGGAA AAGAGGGAAG AAGATGAGGA GAATGACAAT 
GATAATGAAA GTGACCATGA TGAAGCTGAC TCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CHRAC1 ( NM_017444.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_059140.1 Homo sapiens chromatin accessibility complex 1 (CHRAC1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu07666
Clone ID Related Accession (Same CDS sequence)	NM_017444.6 , NM_017444.5
Accession Version	NM_017444.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 396bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	chromatin accessibility complex protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA887467.1, AK023537.1 and AC107375.5. On Aug 3, 2011 this sequence version replaced NM_017444.4. Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK023537.1, SRR1803616.80491.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGACG TGGTCGTGGG TAAAGACAAG GGCGGGGAGC AGCGGCTCAT CTCGCTGCCT 
CTATCCCGCA TCCGGGTCAT CATGAAGAGC TCCCCCGAGG TGTCCAGCAT CAACCAGGAG 
GCGTTGGTGC TCACGGCCAA GGCCACGGAG CTCTTTGTTC AATGCCTAGC CACCTATTCC 
TACAGACACG GCAGTGGAAA GGAAAAGAAA GTACTGACTT ACAGTGATTT AGCAAACACT 
GCACAGCAAT CAGAAACTTT TCAGTTTCTT GCAGATATAT TACCAAAGAA GATTTTAGCT 
AGTAAATACC TGAAAATGCT TAAAGAGGAA AAGAGGGAAG AAGATGAGGA GAATGACAAT 
GATAATGAAA GTGACCATGA TGAAGCTGAC TCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_059140.1
CDS	203..598
Translation	MADVVVGKDKGGEQRLISLPLSRIRVIMKSSPEVSSINQEALVLTAKATELFVQCLATYSYRHGSGKEKKVLTYSDLANTAQQSETFQFLADILPKKILASKYLKMLKEEKREEDEENDNDNESDHDEADS

Target ORF information:

RefSeq Version	NM_017444.5
Organism	Homo sapiens(human)
Definition	Homo sapiens chromatin accessibility complex 1 (CHRAC1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017444.5

ORF Insert Sequence:

ATGGCGGACG TGGTCGTGGG TAAAGACAAG GGCGGGGAGC AGCGGCTCAT CTCGCTGCCT 
CTATCCCGCA TCCGGGTCAT CATGAAGAGC TCCCCCGAGG TGTCCAGCAT CAACCAGGAG 
GCGTTGGTGC TCACGGCCAA GGCCACGGAG CTCTTTGTTC AATGCCTAGC CACCTATTCC 
TACAGACACG GCAGTGGAAA GGAAAAGAAA GTACTGACTT ACAGTGATTT AGCAAACACT 
GCACAGCAAT CAGAAACTTT TCAGTTTCTT GCAGATATAT TACCAAAGAA GATTTTAGCT 
AGTAAATACC TGAAAATGCT TAAAGAGGAA AAGAGGGAAG AAGATGAGGA GAATGACAAT 
GATAATGAAA GTGACCATGA TGAAGCTGAC TCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A siRNA screen identifies RAD21, EIF3H, CHRAC1 and TANC2 as driver genes within the 8q23, 8q24.3 and 17q23 amplicons in breast cancer with effects on cell growth, survival and transformation.
Carcinogenesis35(3)670-82(2014 Mar)
Mahmood SF,Gruel N,Chapeaublanc E,Lescure A,Jones T,Reyal F,Vincent-Salomon A,Raynal V,Pierron G,Perez F,Camonis J,Del Nery E,Delattre O,Radvanyi F,Bernard-Pierrot I

Next-generation sequencing to generate interactome datasets.
Nature methods8(6)478-80(2011 Jun)
Yu H,Tardivo L,Tam S,Weiner E,Gebreab F,Fan C,Svrzikapa N,Hirozane-Kishikawa T,Rietman E,Yang X,Sahalie J,Salehi-Ashtiani K,Hao T,Cusick ME,Hill DE,Roth FP,Braun P,Vidal M

An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin.
Nature genetics32(4)627-32(2002 Dec)
Collins N,Poot RA,Kukimoto I,Garc?a-Jim?nez C,Dellaire G,Varga-Weisz PD

Cloning and characterization of the histone-fold proteins YBL1 and YCL1.
Nucleic acids research28(19)3830-8(2000 Oct)
Bolognese F,Imbriano C,Caretti G,Mantovani R

HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins.
The EMBO journal19(13)3377-87(2000 Jul)
Poot RA,Dellaire G,H?lsmann BB,Grimaldi MA,Corona DF,Becker PB,Bickmore WA,Varga-Weisz PD

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

CHRAC1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報