PMP2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PMP2
Entrez Gene ID	5375
Full Name	peripheral myelin protein 2
Synonyms	FABP8,M-FABP,MP2,P2
General protein information	Preferred Names peripheral myelin protein 2 Names myelin P2 protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8q21.13
Summary	The protein encoded by this gene localizes to myelin sheaths of the peripheral nervous system. The encoded protein can bind both the membrane layers of the sheaths and monomeric lipids, and is thought to provide stability to the sheath. A defect in this gene was shown to be a cause of dominant demyelinating CMT neuropathy. [provided by RefSeq, Jan 2017].
Disorder MIM:	170715

mRNA and Protein(s)

mRNA	Protein	Name
NM_001348381.1	NP_001335310.1	myelin P2 protein isoform 2
NM_002677.4	NP_002668.1	myelin P2 protein isoform 1
NM_002677.3	NP_002668.1	myelin P2 protein
NM_001348381.2	NP_001335310.1	myelin P2 protein isoform 2
NM_002677.5	NP_002668.1	myelin P2 protein isoform 1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Pmp2	NP_001025476.1
Danio rerio (zebrafish)	fabp11a	NP_001004682.1
Homo sapiens (human)	PMP2	NP_002668.1
Bos taurus (cattle)	PMP2	NP_001068707.1
Gallus gallus (chicken)	PMP2	NP_001186405.1
Danio rerio (zebrafish)	LOC100536788	XP_003200662.1
Canis lupus familiaris (dog)	PMP2	XP_544144.2
Danio rerio (zebrafish)	LOC100334189	XP_002667038.2
Caenorhabditis elegans (roundworm)	lbp-9	NP_001033512.1
Pan troglodytes (chimpanzee)	PMP2	XP_001168277.1
	PMP2	XP_001092015.1
Rattus norvegicus (Norway rat)	Pmp2	NP_001102984.1
Danio rerio (zebrafish)	fabp11b	NP_001018394.1

Gene Ontology
Bibliography

Related articles in PubMed

Screening for
Zhao X, Jiang MM, Yan YZ, Liu L, Xie YZ, Li XB, Hu ZM, Zi XH, Xia K, Tang BS, Zhang RX
Chinese medical journal131(2)151-155(2018 Jan)

Molecular mechanisms of Charcot-Marie-Tooth neuropathy linked to mutations in human myelin protein P2.
Ruskamo S, Nieminen T, Kristiansen CK, Vatne GH, Baumann A, Hallin EI, Raasakka A, Joensuu P, Bergmann U, Vattulainen I, Kursula P
Scientific reports7(1)6510(2017 Jul)

De novo PMP2 mutations in families with type 1 Charcot-Marie-Tooth disease.
Motley WW, Palaima P, Yum SW, Gonzalez MA, Tao F, Wanschitz JV, Strickland AV, L?scher WN, De Vriendt E, Koppi S, Medne L, Janecke AR, Jordanova A, Zuchner S, Scherer SS
Brain : a journal of neurology139(Pt 6)1649-56(2016 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Our genetic and clinical findings in these kindred demonstrate that dominant PMP2 mutations cause Charcot-Marie- Tooth disease type 1.
Title: De novo PMP2 mutations in families with type 1 Charcot-Marie-Tooth disease.

This report might expand the genetic and clinical features of Charcot-Marie-Tooth disease and a further mechanism study will enhance our understanding of PMP2-associated peripheral neuropathy.
Title: A Mutation in PMP2 Causes Dominant Demyelinating Charcot-Marie-Tooth Neuropathy.

A fully deuterated sample of myelin P2 protein was produced identifying the neutron crystal structure.
Title: Production, crystallization and neutron diffraction of fully deuterated human myelin peripheral membrane protein P2.

The structure of human P2 refined at the ultrahigh resolution of 0.93 A allows detailed structural analyses, including the full organization of an internal hydrogen-bonding network.
Title: Atomic resolution view into the structure-function relationships of the human myelin peripheral membrane protein P2.

the structure and function of the P2 protein from human myelin, which is able to bind both monomeric lipids inside its cavity and membrane surfaces
Title: Structural and functional characterization of human peripheral nervous system myelin protein P2.

The following PMP2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PMP2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03097	NM_002677.5 Latest version!	Homo sapiens peripheral myelin protein 2 (PMP2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu101430	NM_001348381.2 Latest version!	Homo sapiens peripheral myelin protein 2 (PMP2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu03097	NM_002677.3	Homo sapiens peripheral myelin protein 2 (PMP2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu101430	NM_001348381.1	Homo sapiens peripheral myelin protein 2 (PMP2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu03097	NM_002677.4	Homo sapiens peripheral myelin protein 2 (PMP2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PMP2 ( NM_002677.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002668.1 Homo sapiens peripheral myelin protein 2 (PMP2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu03097
Clone ID Related Accession (Same CDS sequence)	NM_002677.4 , NM_002677.3 , NM_002677.5
Accession Version	NM_002677.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 399bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-09
Organism	Homo sapiens(human)
Product	myelin P2 protein isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA160405.1, BC034997.1 and AC018616.5. This sequence is a reference standard in the RefSeqGene project. On Feb 8, 2017 this sequence version replaced NM_002677.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.232591.1, SRR1660805.255269.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467147, SAMEA2467150 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCAACA AATTCCTGGG CACCTGGAAA CTTGTCTCTA GTGAGAACTT TGACGATTAC 
ATGAAAGCTC TGGGTGTGGG GTTAGCCACC AGAAAACTGG GAAATTTGGC CAAACCCACT 
GTGATCATCA GCAAGAAAGG AGATATTATA ACTATACGAA CTGAAAGTAC CTTTAAAAAT 
ACAGAAATCT CCTTCAAGCT AGGCCAGGAA TTTGAAGAAA CCACAGCTGA CAATAGAAAG 
ACCAAGAGCA TCGTAACCCT GCAGAGAGGA TCACTGAATC AAGTGCAGAG ATGGGATGGC 
AAAGAGACAA CCATAAAGAG AAAGCTAGTG AATGGGAAAA TGGTAGCGGA ATGTAAAATG 
AAGGGCGTGG TGTGCACCAG AATCTATGAG AAGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002668.1
CDS	138..536
Translation	MSNKFLGTWKLVSSENFDDYMKALGVGLATRKLGNLAKPTVIISKKGDIITIRTESTFKNTEISFKLGQEFEETTADNRKTKSIVTLQRGSLNQVQRWDGKETTIKRKLVNGKMVAECKMKGVVCTRIYEKV

Target ORF information:

RefSeq Version	NM_002677.4
Organism	Homo sapiens(human)
Definition	Homo sapiens peripheral myelin protein 2 (PMP2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002677.4

ORF Insert Sequence:

ATGAGCAACA AATTCCTGGG CACCTGGAAA CTTGTCTCTA GTGAGAACTT TGACGATTAC 
ATGAAAGCTC TGGGTGTGGG GTTAGCCACC AGAAAACTGG GAAATTTGGC CAAACCCACT 
GTGATCATCA GCAAGAAAGG AGATATTATA ACTATACGAA CTGAAAGTAC CTTTAAAAAT 
ACAGAAATCT CCTTCAAGCT AGGCCAGGAA TTTGAAGAAA CCACAGCTGA CAATAGAAAG 
ACCAAGAGCA TCGTAACCCT GCAGAGAGGA TCACTGAATC AAGTGCAGAG ATGGGATGGC 
AAAGAGACAA CCATAAAGAG AAAGCTAGTG AATGGGAAAA TGGTAGCGGA ATGTAAAATG 
AAGGGCGTGG TGTGCACCAG AATCTATGAG AAGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PMP2 ( NM_002677.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002668.1 Homo sapiens peripheral myelin protein 2 (PMP2), mRNA.

Price & Availability↑

CloneID	OHu03097
Clone ID Related Accession (Same CDS sequence)	NM_002677.4 , NM_002677.3 , NM_002677.5
Accession Version	NM_002677.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 399bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	myelin P2 protein
Comment

ATGAGCAACA AATTCCTGGG CACCTGGAAA CTTGTCTCTA GTGAGAACTT TGACGATTAC 
ATGAAAGCTC TGGGTGTGGG GTTAGCCACC AGAAAACTGG GAAATTTGGC CAAACCCACT 
GTGATCATCA GCAAGAAAGG AGATATTATA ACTATACGAA CTGAAAGTAC CTTTAAAAAT 
ACAGAAATCT CCTTCAAGCT AGGCCAGGAA TTTGAAGAAA CCACAGCTGA CAATAGAAAG 
ACCAAGAGCA TCGTAACCCT GCAGAGAGGA TCACTGAATC AAGTGCAGAG ATGGGATGGC 
AAAGAGACAA CCATAAAGAG AAAGCTAGTG AATGGGAAAA TGGTAGCGGA ATGTAAAATG 
AAGGGCGTGG TGTGCACCAG AATCTATGAG AAGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002668.1
Translation	MSNKFLGTWKLVSSENFDDYMKALGVGLATRKLGNLAKPTVIISKKGDIITIRTESTFKNTEISFKLGQEFEETTADNRKTKSIVTLQRGSLNQVQRWDGKETTIKRKLVNGKMVAECKMKGVVCTRIYEKV

Target ORF information:

RefSeq Version	NM_002677.3
Organism	Homo sapiens(Human)
Definition	Homo sapiens peripheral myelin protein 2 (PMP2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002677.3

ORF Insert Sequence:

ATGAGCAACA AATTCCTGGG CACCTGGAAA CTTGTCTCTA GTGAGAACTT TGACGATTAC 
ATGAAAGCTC TGGGTGTGGG GTTAGCCACC AGAAAACTGG GAAATTTGGC CAAACCCACT 
GTGATCATCA GCAAGAAAGG AGATATTATA ACTATACGAA CTGAAAGTAC CTTTAAAAAT 
ACAGAAATCT CCTTCAAGCT AGGCCAGGAA TTTGAAGAAA CCACAGCTGA CAATAGAAAG 
ACCAAGAGCA TCGTAACCCT GCAGAGAGGA TCACTGAATC AAGTGCAGAG ATGGGATGGC 
AAAGAGACAA CCATAAAGAG AAAGCTAGTG AATGGGAAAA TGGTAGCGGA ATGTAAAATG 
AAGGGCGTGG TGTGCACCAG AATCTATGAG AAGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PMP2 ( NM_002677.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002668.1 Homo sapiens peripheral myelin protein 2 (PMP2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu03097
Clone ID Related Accession (Same CDS sequence)	NM_002677.4 , NM_002677.3 , NM_002677.5
Accession Version	NM_002677.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 399bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	myelin P2 protein isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA160405.1, BC034997.1 and AC018616.5. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_002677.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC034997.1, SRR1660807.232591.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467147, SAMEA2467150 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000256103.3/ ENSP00000256103.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGCAACA AATTCCTGGG CACCTGGAAA CTTGTCTCTA GTGAGAACTT TGACGATTAC 
ATGAAAGCTC TGGGTGTGGG GTTAGCCACC AGAAAACTGG GAAATTTGGC CAAACCCACT 
GTGATCATCA GCAAGAAAGG AGATATTATA ACTATACGAA CTGAAAGTAC CTTTAAAAAT 
ACAGAAATCT CCTTCAAGCT AGGCCAGGAA TTTGAAGAAA CCACAGCTGA CAATAGAAAG 
ACCAAGAGCA TCGTAACCCT GCAGAGAGGA TCACTGAATC AAGTGCAGAG ATGGGATGGC 
AAAGAGACAA CCATAAAGAG AAAGCTAGTG AATGGGAAAA TGGTAGCGGA ATGTAAAATG 
AAGGGCGTGG TGTGCACCAG AATCTATGAG AAGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002668.1
CDS	54..452
Translation	MSNKFLGTWKLVSSENFDDYMKALGVGLATRKLGNLAKPTVIISKKGDIITIRTESTFKNTEISFKLGQEFEETTADNRKTKSIVTLQRGSLNQVQRWDGKETTIKRKLVNGKMVAECKMKGVVCTRIYEKV

Target ORF information:

RefSeq Version	NM_002677.5
Organism	Homo sapiens(human)
Definition	Homo sapiens peripheral myelin protein 2 (PMP2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002677.5

ORF Insert Sequence:

ATGAGCAACA AATTCCTGGG CACCTGGAAA CTTGTCTCTA GTGAGAACTT TGACGATTAC 
ATGAAAGCTC TGGGTGTGGG GTTAGCCACC AGAAAACTGG GAAATTTGGC CAAACCCACT 
GTGATCATCA GCAAGAAAGG AGATATTATA ACTATACGAA CTGAAAGTAC CTTTAAAAAT 
ACAGAAATCT CCTTCAAGCT AGGCCAGGAA TTTGAAGAAA CCACAGCTGA CAATAGAAAG 
ACCAAGAGCA TCGTAACCCT GCAGAGAGGA TCACTGAATC AAGTGCAGAG ATGGGATGGC 
AAAGAGACAA CCATAAAGAG AAAGCTAGTG AATGGGAAAA TGGTAGCGGA ATGTAAAATG 
AAGGGCGTGG TGTGCACCAG AATCTATGAG AAGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PMP2 ( NM_001348381.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001335310.1 Homo sapiens peripheral myelin protein 2 (PMP2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu101430
Clone ID Related Accession (Same CDS sequence)	NM_001348381.1 , NM_001348381.2
Accession Version	NM_001348381.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 183bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-25
Organism	Homo sapiens(human)
Product	myelin P2 protein isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC018616.5. Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.100681.1, SRR1660809.146058.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCAACA AATTCCTGGG CACCTGGAAA CTTGTCTCTA GTGAGAACTT TGACGATTAC 
ATGAAAGCTC TGGAGCATCG TAACCCTGCA GAGAGGATCA CTGAATCAAG TGCAGAGATG 
GGATGGCAAA GAGACAACCA TAAAGAGAAA GCTAGTGAAT GGGAAAATGG TAGCGGAATG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001335310.1
CDS	138..320
Translation	MSNKFLGTWKLVSSENFDDYMKALEHRNPAERITESSAEMGWQRDNHKEKASEWENGSGM

Target ORF information:

RefSeq Version	NM_001348381.1
Organism	Homo sapiens(human)
Definition	Homo sapiens peripheral myelin protein 2 (PMP2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001348381.1

ORF Insert Sequence:

ATGAGCAACA AATTCCTGGG CACCTGGAAA CTTGTCTCTA GTGAGAACTT TGACGATTAC 
ATGAAAGCTC TGGAGCATCG TAACCCTGCA GAGAGGATCA CTGAATCAAG TGCAGAGATG 
GGATGGCAAA GAGACAACCA TAAAGAGAAA GCTAGTGAAT GGGAAAATGG TAGCGGAATG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PMP2 ( NM_001348381.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001335310.1 Homo sapiens peripheral myelin protein 2 (PMP2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu101430
Clone ID Related Accession (Same CDS sequence)	NM_001348381.1 , NM_001348381.2
Accession Version	NM_001348381.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 183bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	myelin P2 protein isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC018616.5. On May 31, 2019 this sequence version replaced NM_001348381.1. Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7410570.430143.1, SRR1660809.146058.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCAACA AATTCCTGGG CACCTGGAAA CTTGTCTCTA GTGAGAACTT TGACGATTAC 
ATGAAAGCTC TGGAGCATCG TAACCCTGCA GAGAGGATCA CTGAATCAAG TGCAGAGATG 
GGATGGCAAA GAGACAACCA TAAAGAGAAA GCTAGTGAAT GGGAAAATGG TAGCGGAATG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001335310.1
CDS	54..236
Translation	MSNKFLGTWKLVSSENFDDYMKALEHRNPAERITESSAEMGWQRDNHKEKASEWENGSGM

Target ORF information:

RefSeq Version	NM_001348381.2
Organism	Homo sapiens(human)
Definition	Homo sapiens peripheral myelin protein 2 (PMP2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001348381.2

ORF Insert Sequence:

ATGAGCAACA AATTCCTGGG CACCTGGAAA CTTGTCTCTA GTGAGAACTT TGACGATTAC 
ATGAAAGCTC TGGAGCATCG TAACCCTGCA GAGAGGATCA CTGAATCAAG TGCAGAGATG 
GGATGGCAAA GAGACAACCA TAAAGAGAAA GCTAGTGAAT GGGAAAATGG TAGCGGAATG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Screening for
Chinese medical journal131(2)151-155(2018 Jan)
Zhao X,Jiang MM,Yan YZ,Liu L,Xie YZ,Li XB,Hu ZM,Zi XH,Xia K,Tang BS,Zhang RX

Molecular mechanisms of Charcot-Marie-Tooth neuropathy linked to mutations in human myelin protein P2.
Scientific reports7(1)6510(2017 Jul)
Ruskamo S,Nieminen T,Kristiansen CK,Vatne GH,Baumann A,Hallin EI,Raasakka A,Joensuu P,Bergmann U,Vattulainen I,Kursula P

De novo PMP2 mutations in families with type 1 Charcot-Marie-Tooth disease.
Brain : a journal of neurology139(Pt 6)1649-56(2016 Jun)
Motley WW,Palaima P,Yum SW,Gonzalez MA,Tao F,Wanschitz JV,Strickland AV,L?scher WN,De Vriendt E,Koppi S,Medne L,Janecke AR,Jordanova A,Zuchner S,Scherer SS

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PMP2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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オンラインフォーム

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