S1PR5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	S1PR5
Entrez Gene ID	53637
Full Name	sphingosine-1-phosphate receptor 5
Synonyms	EDG8,Edg-8,S1P5,SPPR-1,SPPR-2
General protein information	Preferred Names sphingosine-1-phosphate receptor 5 Names sphingosine 1-phosphate receptor 5 S1P receptor 5 S1P receptor Edg-8 endothelial differentiation G-protein-coupled receptor 8 endothelial differentiation, sphingolipid G-protein-coupled receptor, 8 sphingosine 1-phosphate receptor EDG8 sphingosine 1-phosphate receptor Edg-8
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.2
Summary	The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008].
Disorder MIM:	605146

mRNA and Protein(s)

mRNA	Protein	Name
NM_030760.5	NP_110387.1	sphingosine 1-phosphate receptor 5
NM_001166215.2	NP_001159687.1	sphingosine 1-phosphate receptor 5
NM_001166215.1	NP_001159687.1	sphingosine 1-phosphate receptor 5
NM_030760.4	NP_110387.1	sphingosine 1-phosphate receptor 5

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	S1PR5	XP_003316134.1
Bos taurus (cattle)	S1PR5	NP_001179404.1
	S1PR5	XP_001101585.2
Canis lupus familiaris (dog)	S1PR5	XP_005632952.1
Mus musculus (house mouse)	S1pr5	NP_444420.1
Danio rerio (zebrafish)	s1pr5b	NP_001073124.1
Homo sapiens (human)	S1PR5	NP_001159687.1
Rattus norvegicus (Norway rat)	S1pr5	NP_068543.2

Gene Ontology
Bibliography

Related articles in PubMed

S1PR5 is essential for human natural killer cell migration toward sphingosine-1 phosphate.
Drouillard A, Mathieu AL, Mar?ais A, Belot A, Viel S, Mingueneau M, Guckian K, Walzer T
The Journal of allergy and clinical immunology(2017 Dec)

Sphingosine 1-phosphate signaling through its receptor S1P
Andrieu G, Ledoux A, Branka S, Bocquet M, Gilhodes J, Walzer T, Kasahara K, Inagaki M, Sabbadini RA, Cuvillier O, Hatzoglou A
Science signaling10(472)(2017 Mar)

Reduced DNA methylation of sphingosine-1 phosphate receptor 5 in alveolar macrophages in COPD: A potential link to failed efferocytosis.
Barnawi J, Jersmann H, Haberberger R, Hodge S, Meech R
Respirology (Carlton, Vic.)22(2)315-321(2017 02)

Transforming growth factor ?2 (TGF-?2)-induced connective tissue growth factor (CTGF) expression requires sphingosine 1-phosphate receptor 5 (S1P5) in human mesangial cells.
W?nsche C, Koch A, Goldschmeding R, Schwalm S, Meyer Zu Heringdorf D, Huwiler A, Pfeilschifter J
Biochimica et biophysica acta1851(5)519-26(2015 May)

The role of sphingosine kinase isoforms and receptors S1P1, S1P2, S1P3, and S1P5 in primary, secondary, and recurrent glioblastomas.
Quint K, Stiel N, Neureiter D, Schlicker HU, Nimsky C, Ocker M, Strik H, Kolodziej MA
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine35(9)8979-89(2014 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate that the mitotic kinase Polo-like kinase 1 (PLK1) was an important effector of S1P-S1P5 signaling, and a new function of the SphK1-S1P pathway specifically in the control of mitosis in HeLa cells.
Title: Sphingosine 1-phosphate signaling through its receptor S1P

Reduced DNA methylation may underlie the increased expression of the S1PR5 gene in alveolar macrophages and associated defective efferocytosis in COPD.
Title: Reduced DNA methylation of sphingosine-1 phosphate receptor 5 in alveolar macrophages in COPD: A potential link to failed efferocytosis.

TGF-beta2 dependent upregulation of S1P5 is required for the induction of pro-fibrotic CTGF by TGF-beta in mesangial cells.
Title: Transforming growth factor ?2 (TGF-?2)-induced connective tissue growth factor (CTGF) expression requires sphingosine 1-phosphate receptor 5 (S1P5) in human mesangial cells.

Data show that sphingosine kinase SphK1 and sphingosine-1-phosphate (S1P) receptors S1P1, S1P2, S1P3, and S1P5 were expressed from primary, up to recurrent and secondary glioblastomas, with sphingosine kinase SphK2 levels were highest in primary tumors.
Title: The role of sphingosine kinase isoforms and receptors S1P1, S1P2, S1P3, and S1P5 in primary, secondary, and recurrent glioblastomas.

This report is the first to demonstrate a reduction in S1P5 in multiple sclerosis lesions, which parallels that of myelin loss.
Title: Immunohistochemical detection of sphingosine-1-phosphate receptor 1 and 5 in human multiple sclerosis lesions.

The following S1PR5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the S1PR5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu01303	NM_001166215.2 Latest version!	Homo sapiens sphingosine-1-phosphate receptor 5 (S1PR5), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu01303	NM_030760.5 Latest version!	Homo sapiens sphingosine-1-phosphate receptor 5 (S1PR5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu01303	NM_001166215.1	Homo sapiens sphingosine-1-phosphate receptor 5 (S1PR5), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu01303	NM_030760.4	Homo sapiens sphingosine-1-phosphate receptor 5 (S1PR5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

S1PR5 ( NM_030760.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_110387.1 Homo sapiens sphingosine-1-phosphate receptor 5 (S1PR5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu01303
Clone ID Related Accession (Same CDS sequence)	NM_030760.5 , NM_001166215.2 , NM_001166215.1 , NM_030760.4
Accession Version	NM_030760.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1197bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Homo sapiens(human)
Product	sphingosine 1-phosphate receptor 5
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA747912.1, BC034703.1, AC011461.5 and AF331840.1. On Nov 23, 2018 this sequence version replaced NM_030760.4. Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA931194.1, BC034703.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142680, SAMEA2145893 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000333430.6/ ENSP00000328472.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGTCGG GGCTGCTGCG GCCGGCGCCG GTGAGCGAGG TCATCGTCCT GCATTACAAC 
TACACCGGCA AGCTCCGCGG TGCGCGCTAC CAGCCGGGTG CCGGCCTGCG CGCCGACGCC 
GTGGTGTGCC TGGCGGTGTG CGCCTTCATC GTGCTAGAGA ATCTAGCCGT GTTGTTGGTG 
CTCGGACGCC ACCCGCGCTT CCACGCTCCC ATGTTCCTGC TCCTGGGCAG CCTCACGTTG 
TCGGATCTGC TGGCAGGCGC CGCCTACGCC GCCAACATCC TACTGTCGGG GCCGCTCACG 
CTGAAACTGT CCCCCGCGCT CTGGTTCGCA CGGGAGGGAG GCGTCTTCGT GGCACTCACT 
GCGTCCGTGC TGAGCCTCCT GGCCATCGCG CTGGAGCGCA GCCTCACCAT GGCGCGCAGG 
GGGCCCGCGC CCGTCTCCAG TCGGGGGCGC ACGCTGGCGA TGGCAGCCGC GGCCTGGGGC 
GTGTCGCTGC TCCTCGGGCT CCTGCCAGCG CTGGGCTGGA ATTGCCTGGG TCGCCTGGAC 
GCTTGCTCCA CTGTCTTGCC GCTCTACGCC AAGGCCTACG TGCTCTTCTG CGTGCTCGCC 
TTCGTGGGCA TCCTGGCCGC TATCTGTGCA CTCTACGCGC GCATCTACTG CCAGGTACGC 
GCCAACGCGC GGCGCCTGCC GGCACGGCCC GGGACTGCGG GGACCACCTC GACCCGGGCG 
CGTCGCAAGC CGCGCTCGCT GGCCTTGCTG CGCACGCTCA GCGTGGTGCT CCTGGCCTTT 
GTGGCATGTT GGGGCCCCCT CTTCCTGCTG CTGTTGCTCG ACGTGGCGTG CCCGGCGCGC 
ACCTGTCCTG TACTCCTGCA GGCCGATCCC TTCCTGGGAC TGGCCATGGC CAACTCACTT 
CTGAACCCCA TCATCTACAC GCTCACCAAC CGCGACCTGC GCCACGCGCT CCTGCGCCTG 
GTCTGCTGCG GACGCCACTC CTGCGGCAGA GACCCGAGTG GCTCCCAGCA GTCGGCGAGC 
GCGGCTGAGG CTTCCGGGGG CCTGCGCCGC TGCCTGCCCC CGGGCCTTGA TGGGAGCTTC 
AGCGGCTCGG AGCGCTCATC GCCCCAGCGC GACGGGCTGG ACACCAGCGG CTCCACAGGC 
AGCCCCGGTG CACCCACAGC CGCCCGGACT CTGGTATCAG AACCGGCTGC AGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_110387.1
CDS	69..1265
Translation	MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSLLNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSFSGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD

Target ORF information:

RefSeq Version	NM_030760.5
Organism	Homo sapiens(human)
Definition	Homo sapiens sphingosine-1-phosphate receptor 5 (S1PR5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030760.5

ORF Insert Sequence:

ATGGAGTCGG GGCTGCTGCG GCCGGCGCCG GTGAGCGAGG TCATCGTCCT GCATTACAAC 
TACACCGGCA AGCTCCGCGG TGCGCGCTAC CAGCCGGGTG CCGGCCTGCG CGCCGACGCC 
GTGGTGTGCC TGGCGGTGTG CGCCTTCATC GTGCTAGAGA ATCTAGCCGT GTTGTTGGTG 
CTCGGACGCC ACCCGCGCTT CCACGCTCCC ATGTTCCTGC TCCTGGGCAG CCTCACGTTG 
TCGGATCTGC TGGCAGGCGC CGCCTACGCC GCCAACATCC TACTGTCGGG GCCGCTCACG 
CTGAAACTGT CCCCCGCGCT CTGGTTCGCA CGGGAGGGAG GCGTCTTCGT GGCACTCACT 
GCGTCCGTGC TGAGCCTCCT GGCCATCGCG CTGGAGCGCA GCCTCACCAT GGCGCGCAGG 
GGGCCCGCGC CCGTCTCCAG TCGGGGGCGC ACGCTGGCGA TGGCAGCCGC GGCCTGGGGC 
GTGTCGCTGC TCCTCGGGCT CCTGCCAGCG CTGGGCTGGA ATTGCCTGGG TCGCCTGGAC 
GCTTGCTCCA CTGTCTTGCC GCTCTACGCC AAGGCCTACG TGCTCTTCTG CGTGCTCGCC 
TTCGTGGGCA TCCTGGCCGC TATCTGTGCA CTCTACGCGC GCATCTACTG CCAGGTACGC 
GCCAACGCGC GGCGCCTGCC GGCACGGCCC GGGACTGCGG GGACCACCTC GACCCGGGCG 
CGTCGCAAGC CGCGCTCGCT GGCCTTGCTG CGCACGCTCA GCGTGGTGCT CCTGGCCTTT 
GTGGCATGTT GGGGCCCCCT CTTCCTGCTG CTGTTGCTCG ACGTGGCGTG CCCGGCGCGC 
ACCTGTCCTG TACTCCTGCA GGCCGATCCC TTCCTGGGAC TGGCCATGGC CAACTCACTT 
CTGAACCCCA TCATCTACAC GCTCACCAAC CGCGACCTGC GCCACGCGCT CCTGCGCCTG 
GTCTGCTGCG GACGCCACTC CTGCGGCAGA GACCCGAGTG GCTCCCAGCA GTCGGCGAGC 
GCGGCTGAGG CTTCCGGGGG CCTGCGCCGC TGCCTGCCCC CGGGCCTTGA TGGGAGCTTC 
AGCGGCTCGG AGCGCTCATC GCCCCAGCGC GACGGGCTGG ACACCAGCGG CTCCACAGGC 
AGCCCCGGTG CACCCACAGC CGCCCGGACT CTGGTATCAG AACCGGCTGC AGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

S1PR5 ( NM_001166215.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001159687.1 Homo sapiens sphingosine-1-phosphate receptor 5 (S1PR5), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu01303
Clone ID Related Accession (Same CDS sequence)	NM_030760.5 , NM_001166215.2 , NM_001166215.1 , NM_030760.4
Accession Version	NM_001166215.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1197bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Homo sapiens(human)
Product	sphingosine 1-phosphate receptor 5
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB013424.1, DA866378.1, BC034703.1, AC011461.5 and AF331840.1. On May 31, 2019 this sequence version replaced NM_001166215.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK074661.1, SRR1803617.257904.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2144333 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGTCGG GGCTGCTGCG GCCGGCGCCG GTGAGCGAGG TCATCGTCCT GCATTACAAC 
TACACCGGCA AGCTCCGCGG TGCGCGCTAC CAGCCGGGTG CCGGCCTGCG CGCCGACGCC 
GTGGTGTGCC TGGCGGTGTG CGCCTTCATC GTGCTAGAGA ATCTAGCCGT GTTGTTGGTG 
CTCGGACGCC ACCCGCGCTT CCACGCTCCC ATGTTCCTGC TCCTGGGCAG CCTCACGTTG 
TCGGATCTGC TGGCAGGCGC CGCCTACGCC GCCAACATCC TACTGTCGGG GCCGCTCACG 
CTGAAACTGT CCCCCGCGCT CTGGTTCGCA CGGGAGGGAG GCGTCTTCGT GGCACTCACT 
GCGTCCGTGC TGAGCCTCCT GGCCATCGCG CTGGAGCGCA GCCTCACCAT GGCGCGCAGG 
GGGCCCGCGC CCGTCTCCAG TCGGGGGCGC ACGCTGGCGA TGGCAGCCGC GGCCTGGGGC 
GTGTCGCTGC TCCTCGGGCT CCTGCCAGCG CTGGGCTGGA ATTGCCTGGG TCGCCTGGAC 
GCTTGCTCCA CTGTCTTGCC GCTCTACGCC AAGGCCTACG TGCTCTTCTG CGTGCTCGCC 
TTCGTGGGCA TCCTGGCCGC TATCTGTGCA CTCTACGCGC GCATCTACTG CCAGGTACGC 
GCCAACGCGC GGCGCCTGCC GGCACGGCCC GGGACTGCGG GGACCACCTC GACCCGGGCG 
CGTCGCAAGC CGCGCTCGCT GGCCTTGCTG CGCACGCTCA GCGTGGTGCT CCTGGCCTTT 
GTGGCATGTT GGGGCCCCCT CTTCCTGCTG CTGTTGCTCG ACGTGGCGTG CCCGGCGCGC 
ACCTGTCCTG TACTCCTGCA GGCCGATCCC TTCCTGGGAC TGGCCATGGC CAACTCACTT 
CTGAACCCCA TCATCTACAC GCTCACCAAC CGCGACCTGC GCCACGCGCT CCTGCGCCTG 
GTCTGCTGCG GACGCCACTC CTGCGGCAGA GACCCGAGTG GCTCCCAGCA GTCGGCGAGC 
GCGGCTGAGG CTTCCGGGGG CCTGCGCCGC TGCCTGCCCC CGGGCCTTGA TGGGAGCTTC 
AGCGGCTCGG AGCGCTCATC GCCCCAGCGC GACGGGCTGG ACACCAGCGG CTCCACAGGC 
AGCCCCGGTG CACCCACAGC CGCCCGGACT CTGGTATCAG AACCGGCTGC AGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001159687.1
CDS	161..1357
Translation	MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSLLNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSFSGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD

Target ORF information:

RefSeq Version	NM_001166215.2
Organism	Homo sapiens(human)
Definition	Homo sapiens sphingosine-1-phosphate receptor 5 (S1PR5), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001166215.2

ORF Insert Sequence:

ATGGAGTCGG GGCTGCTGCG GCCGGCGCCG GTGAGCGAGG TCATCGTCCT GCATTACAAC 
TACACCGGCA AGCTCCGCGG TGCGCGCTAC CAGCCGGGTG CCGGCCTGCG CGCCGACGCC 
GTGGTGTGCC TGGCGGTGTG CGCCTTCATC GTGCTAGAGA ATCTAGCCGT GTTGTTGGTG 
CTCGGACGCC ACCCGCGCTT CCACGCTCCC ATGTTCCTGC TCCTGGGCAG CCTCACGTTG 
TCGGATCTGC TGGCAGGCGC CGCCTACGCC GCCAACATCC TACTGTCGGG GCCGCTCACG 
CTGAAACTGT CCCCCGCGCT CTGGTTCGCA CGGGAGGGAG GCGTCTTCGT GGCACTCACT 
GCGTCCGTGC TGAGCCTCCT GGCCATCGCG CTGGAGCGCA GCCTCACCAT GGCGCGCAGG 
GGGCCCGCGC CCGTCTCCAG TCGGGGGCGC ACGCTGGCGA TGGCAGCCGC GGCCTGGGGC 
GTGTCGCTGC TCCTCGGGCT CCTGCCAGCG CTGGGCTGGA ATTGCCTGGG TCGCCTGGAC 
GCTTGCTCCA CTGTCTTGCC GCTCTACGCC AAGGCCTACG TGCTCTTCTG CGTGCTCGCC 
TTCGTGGGCA TCCTGGCCGC TATCTGTGCA CTCTACGCGC GCATCTACTG CCAGGTACGC 
GCCAACGCGC GGCGCCTGCC GGCACGGCCC GGGACTGCGG GGACCACCTC GACCCGGGCG 
CGTCGCAAGC CGCGCTCGCT GGCCTTGCTG CGCACGCTCA GCGTGGTGCT CCTGGCCTTT 
GTGGCATGTT GGGGCCCCCT CTTCCTGCTG CTGTTGCTCG ACGTGGCGTG CCCGGCGCGC 
ACCTGTCCTG TACTCCTGCA GGCCGATCCC TTCCTGGGAC TGGCCATGGC CAACTCACTT 
CTGAACCCCA TCATCTACAC GCTCACCAAC CGCGACCTGC GCCACGCGCT CCTGCGCCTG 
GTCTGCTGCG GACGCCACTC CTGCGGCAGA GACCCGAGTG GCTCCCAGCA GTCGGCGAGC 
GCGGCTGAGG CTTCCGGGGG CCTGCGCCGC TGCCTGCCCC CGGGCCTTGA TGGGAGCTTC 
AGCGGCTCGG AGCGCTCATC GCCCCAGCGC GACGGGCTGG ACACCAGCGG CTCCACAGGC 
AGCCCCGGTG CACCCACAGC CGCCCGGACT CTGGTATCAG AACCGGCTGC AGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

S1PR5 ( NM_001166215.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001159687.1 Homo sapiens sphingosine-1-phosphate receptor 5 (S1PR5), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu01303
Clone ID Related Accession (Same CDS sequence)	NM_030760.5 , NM_001166215.2 , NM_001166215.1 , NM_030760.4
Accession Version	NM_001166215.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1197bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	sphingosine 1-phosphate receptor 5
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB013424.1, DA866378.1, BC034703.1, AC011461.5 and AF331840.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK074661.1, SRR1803617.257904.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2144333 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGTCGG GGCTGCTGCG GCCGGCGCCG GTGAGCGAGG TCATCGTCCT GCATTACAAC 
TACACCGGCA AGCTCCGCGG TGCGCGCTAC CAGCCGGGTG CCGGCCTGCG CGCCGACGCC 
GTGGTGTGCC TGGCGGTGTG CGCCTTCATC GTGCTAGAGA ATCTAGCCGT GTTGTTGGTG 
CTCGGACGCC ACCCGCGCTT CCACGCTCCC ATGTTCCTGC TCCTGGGCAG CCTCACGTTG 
TCGGATCTGC TGGCAGGCGC CGCCTACGCC GCCAACATCC TACTGTCGGG GCCGCTCACG 
CTGAAACTGT CCCCCGCGCT CTGGTTCGCA CGGGAGGGAG GCGTCTTCGT GGCACTCACT 
GCGTCCGTGC TGAGCCTCCT GGCCATCGCG CTGGAGCGCA GCCTCACCAT GGCGCGCAGG 
GGGCCCGCGC CCGTCTCCAG TCGGGGGCGC ACGCTGGCGA TGGCAGCCGC GGCCTGGGGC 
GTGTCGCTGC TCCTCGGGCT CCTGCCAGCG CTGGGCTGGA ATTGCCTGGG TCGCCTGGAC 
GCTTGCTCCA CTGTCTTGCC GCTCTACGCC AAGGCCTACG TGCTCTTCTG CGTGCTCGCC 
TTCGTGGGCA TCCTGGCCGC TATCTGTGCA CTCTACGCGC GCATCTACTG CCAGGTACGC 
GCCAACGCGC GGCGCCTGCC GGCACGGCCC GGGACTGCGG GGACCACCTC GACCCGGGCG 
CGTCGCAAGC CGCGCTCGCT GGCCTTGCTG CGCACGCTCA GCGTGGTGCT CCTGGCCTTT 
GTGGCATGTT GGGGCCCCCT CTTCCTGCTG CTGTTGCTCG ACGTGGCGTG CCCGGCGCGC 
ACCTGTCCTG TACTCCTGCA GGCCGATCCC TTCCTGGGAC TGGCCATGGC CAACTCACTT 
CTGAACCCCA TCATCTACAC GCTCACCAAC CGCGACCTGC GCCACGCGCT CCTGCGCCTG 
GTCTGCTGCG GACGCCACTC CTGCGGCAGA GACCCGAGTG GCTCCCAGCA GTCGGCGAGC 
GCGGCTGAGG CTTCCGGGGG CCTGCGCCGC TGCCTGCCCC CGGGCCTTGA TGGGAGCTTC 
AGCGGCTCGG AGCGCTCATC GCCCCAGCGC GACGGGCTGG ACACCAGCGG CTCCACAGGC 
AGCCCCGGTG CACCCACAGC CGCCCGGACT CTGGTATCAG AACCGGCTGC AGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001159687.1
CDS	188..1384
Translation	MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSLLNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSFSGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD

Target ORF information:

RefSeq Version	NM_001166215.1
Organism	Homo sapiens(human)
Definition	Homo sapiens sphingosine-1-phosphate receptor 5 (S1PR5), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001166215.1

ORF Insert Sequence:

ATGGAGTCGG GGCTGCTGCG GCCGGCGCCG GTGAGCGAGG TCATCGTCCT GCATTACAAC 
TACACCGGCA AGCTCCGCGG TGCGCGCTAC CAGCCGGGTG CCGGCCTGCG CGCCGACGCC 
GTGGTGTGCC TGGCGGTGTG CGCCTTCATC GTGCTAGAGA ATCTAGCCGT GTTGTTGGTG 
CTCGGACGCC ACCCGCGCTT CCACGCTCCC ATGTTCCTGC TCCTGGGCAG CCTCACGTTG 
TCGGATCTGC TGGCAGGCGC CGCCTACGCC GCCAACATCC TACTGTCGGG GCCGCTCACG 
CTGAAACTGT CCCCCGCGCT CTGGTTCGCA CGGGAGGGAG GCGTCTTCGT GGCACTCACT 
GCGTCCGTGC TGAGCCTCCT GGCCATCGCG CTGGAGCGCA GCCTCACCAT GGCGCGCAGG 
GGGCCCGCGC CCGTCTCCAG TCGGGGGCGC ACGCTGGCGA TGGCAGCCGC GGCCTGGGGC 
GTGTCGCTGC TCCTCGGGCT CCTGCCAGCG CTGGGCTGGA ATTGCCTGGG TCGCCTGGAC 
GCTTGCTCCA CTGTCTTGCC GCTCTACGCC AAGGCCTACG TGCTCTTCTG CGTGCTCGCC 
TTCGTGGGCA TCCTGGCCGC TATCTGTGCA CTCTACGCGC GCATCTACTG CCAGGTACGC 
GCCAACGCGC GGCGCCTGCC GGCACGGCCC GGGACTGCGG GGACCACCTC GACCCGGGCG 
CGTCGCAAGC CGCGCTCGCT GGCCTTGCTG CGCACGCTCA GCGTGGTGCT CCTGGCCTTT 
GTGGCATGTT GGGGCCCCCT CTTCCTGCTG CTGTTGCTCG ACGTGGCGTG CCCGGCGCGC 
ACCTGTCCTG TACTCCTGCA GGCCGATCCC TTCCTGGGAC TGGCCATGGC CAACTCACTT 
CTGAACCCCA TCATCTACAC GCTCACCAAC CGCGACCTGC GCCACGCGCT CCTGCGCCTG 
GTCTGCTGCG GACGCCACTC CTGCGGCAGA GACCCGAGTG GCTCCCAGCA GTCGGCGAGC 
GCGGCTGAGG CTTCCGGGGG CCTGCGCCGC TGCCTGCCCC CGGGCCTTGA TGGGAGCTTC 
AGCGGCTCGG AGCGCTCATC GCCCCAGCGC GACGGGCTGG ACACCAGCGG CTCCACAGGC 
AGCCCCGGTG CACCCACAGC CGCCCGGACT CTGGTATCAG AACCGGCTGC AGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

S1PR5 ( NM_030760.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_110387.1 Homo sapiens sphingosine-1-phosphate receptor 5 (S1PR5), transcript variant 1, mRNA.

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CloneID	OHu01303
Clone ID Related Accession (Same CDS sequence)	NM_030760.5 , NM_001166215.2 , NM_001166215.1 , NM_030760.4
Accession Version	NM_030760.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1197bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-28
Organism	Homo sapiens(human)
Product	sphingosine 1-phosphate receptor 5
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA747912.1, BC034703.1, AC011461.5 and AF331840.1. On Oct 14, 2009 this sequence version replaced NM_030760.3. Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC034703.1, SRR1660803.33143.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142680, SAMEA2145893 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGTCGG GGCTGCTGCG GCCGGCGCCG GTGAGCGAGG TCATCGTCCT GCATTACAAC 
TACACCGGCA AGCTCCGCGG TGCGCGCTAC CAGCCGGGTG CCGGCCTGCG CGCCGACGCC 
GTGGTGTGCC TGGCGGTGTG CGCCTTCATC GTGCTAGAGA ATCTAGCCGT GTTGTTGGTG 
CTCGGACGCC ACCCGCGCTT CCACGCTCCC ATGTTCCTGC TCCTGGGCAG CCTCACGTTG 
TCGGATCTGC TGGCAGGCGC CGCCTACGCC GCCAACATCC TACTGTCGGG GCCGCTCACG 
CTGAAACTGT CCCCCGCGCT CTGGTTCGCA CGGGAGGGAG GCGTCTTCGT GGCACTCACT 
GCGTCCGTGC TGAGCCTCCT GGCCATCGCG CTGGAGCGCA GCCTCACCAT GGCGCGCAGG 
GGGCCCGCGC CCGTCTCCAG TCGGGGGCGC ACGCTGGCGA TGGCAGCCGC GGCCTGGGGC 
GTGTCGCTGC TCCTCGGGCT CCTGCCAGCG CTGGGCTGGA ATTGCCTGGG TCGCCTGGAC 
GCTTGCTCCA CTGTCTTGCC GCTCTACGCC AAGGCCTACG TGCTCTTCTG CGTGCTCGCC 
TTCGTGGGCA TCCTGGCCGC TATCTGTGCA CTCTACGCGC GCATCTACTG CCAGGTACGC 
GCCAACGCGC GGCGCCTGCC GGCACGGCCC GGGACTGCGG GGACCACCTC GACCCGGGCG 
CGTCGCAAGC CGCGCTCGCT GGCCTTGCTG CGCACGCTCA GCGTGGTGCT CCTGGCCTTT 
GTGGCATGTT GGGGCCCCCT CTTCCTGCTG CTGTTGCTCG ACGTGGCGTG CCCGGCGCGC 
ACCTGTCCTG TACTCCTGCA GGCCGATCCC TTCCTGGGAC TGGCCATGGC CAACTCACTT 
CTGAACCCCA TCATCTACAC GCTCACCAAC CGCGACCTGC GCCACGCGCT CCTGCGCCTG 
GTCTGCTGCG GACGCCACTC CTGCGGCAGA GACCCGAGTG GCTCCCAGCA GTCGGCGAGC 
GCGGCTGAGG CTTCCGGGGG CCTGCGCCGC TGCCTGCCCC CGGGCCTTGA TGGGAGCTTC 
AGCGGCTCGG AGCGCTCATC GCCCCAGCGC GACGGGCTGG ACACCAGCGG CTCCACAGGC 
AGCCCCGGTG CACCCACAGC CGCCCGGACT CTGGTATCAG AACCGGCTGC AGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_110387.1
CDS	72..1268
Translation	MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSLLNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSFSGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD

Target ORF information:

RefSeq Version	NM_030760.4
Organism	Homo sapiens(human)
Definition	Homo sapiens sphingosine-1-phosphate receptor 5 (S1PR5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030760.4

ORF Insert Sequence:

ATGGAGTCGG GGCTGCTGCG GCCGGCGCCG GTGAGCGAGG TCATCGTCCT GCATTACAAC 
TACACCGGCA AGCTCCGCGG TGCGCGCTAC CAGCCGGGTG CCGGCCTGCG CGCCGACGCC 
GTGGTGTGCC TGGCGGTGTG CGCCTTCATC GTGCTAGAGA ATCTAGCCGT GTTGTTGGTG 
CTCGGACGCC ACCCGCGCTT CCACGCTCCC ATGTTCCTGC TCCTGGGCAG CCTCACGTTG 
TCGGATCTGC TGGCAGGCGC CGCCTACGCC GCCAACATCC TACTGTCGGG GCCGCTCACG 
CTGAAACTGT CCCCCGCGCT CTGGTTCGCA CGGGAGGGAG GCGTCTTCGT GGCACTCACT 
GCGTCCGTGC TGAGCCTCCT GGCCATCGCG CTGGAGCGCA GCCTCACCAT GGCGCGCAGG 
GGGCCCGCGC CCGTCTCCAG TCGGGGGCGC ACGCTGGCGA TGGCAGCCGC GGCCTGGGGC 
GTGTCGCTGC TCCTCGGGCT CCTGCCAGCG CTGGGCTGGA ATTGCCTGGG TCGCCTGGAC 
GCTTGCTCCA CTGTCTTGCC GCTCTACGCC AAGGCCTACG TGCTCTTCTG CGTGCTCGCC 
TTCGTGGGCA TCCTGGCCGC TATCTGTGCA CTCTACGCGC GCATCTACTG CCAGGTACGC 
GCCAACGCGC GGCGCCTGCC GGCACGGCCC GGGACTGCGG GGACCACCTC GACCCGGGCG 
CGTCGCAAGC CGCGCTCGCT GGCCTTGCTG CGCACGCTCA GCGTGGTGCT CCTGGCCTTT 
GTGGCATGTT GGGGCCCCCT CTTCCTGCTG CTGTTGCTCG ACGTGGCGTG CCCGGCGCGC 
ACCTGTCCTG TACTCCTGCA GGCCGATCCC TTCCTGGGAC TGGCCATGGC CAACTCACTT 
CTGAACCCCA TCATCTACAC GCTCACCAAC CGCGACCTGC GCCACGCGCT CCTGCGCCTG 
GTCTGCTGCG GACGCCACTC CTGCGGCAGA GACCCGAGTG GCTCCCAGCA GTCGGCGAGC 
GCGGCTGAGG CTTCCGGGGG CCTGCGCCGC TGCCTGCCCC CGGGCCTTGA TGGGAGCTTC 
AGCGGCTCGG AGCGCTCATC GCCCCAGCGC GACGGGCTGG ACACCAGCGG CTCCACAGGC 
AGCCCCGGTG CACCCACAGC CGCCCGGACT CTGGTATCAG AACCGGCTGC AGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

S1PR5 is essential for human natural killer cell migration toward sphingosine-1 phosphate.
The Journal of allergy and clinical immunology(2017 Dec)
Drouillard A,Mathieu AL,Mar?ais A,Belot A,Viel S,Mingueneau M,Guckian K,Walzer T

Sphingosine 1-phosphate signaling through its receptor S1P
Science signaling10(472)(2017 Mar)
Andrieu G,Ledoux A,Branka S,Bocquet M,Gilhodes J,Walzer T,Kasahara K,Inagaki M,Sabbadini RA,Cuvillier O,Hatzoglou A

Reduced DNA methylation of sphingosine-1 phosphate receptor 5 in alveolar macrophages in COPD: A potential link to failed efferocytosis.
Respirology (Carlton, Vic.)22(2)315-321(2017 02)
Barnawi J,Jersmann H,Haberberger R,Hodge S,Meech R

Transforming growth factor ?2 (TGF-?2)-induced connective tissue growth factor (CTGF) expression requires sphingosine 1-phosphate receptor 5 (S1P5) in human mesangial cells.
Biochimica et biophysica acta1851(5)519-26(2015 May)
W?nsche C,Koch A,Goldschmeding R,Schwalm S,Meyer Zu Heringdorf D,Huwiler A,Pfeilschifter J

The role of sphingosine kinase isoforms and receptors S1P1, S1P2, S1P3, and S1P5 in primary, secondary, and recurrent glioblastomas.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine35(9)8979-89(2014 Sep)
Quint K,Stiel N,Neureiter D,Schlicker HU,Nimsky C,Ocker M,Strik H,Kolodziej MA

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S1PR5 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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