PLP2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PLP2
Entrez Gene ID	5355
Full Name	proteolipid protein 2
Synonyms	A4,A4LSB
General protein information	Preferred Names proteolipid protein 2 Names proteolipid protein 2 A4 differentiation-dependent protein differentiation-dependent protein A4 intestinal membrane A4 protein proteolipid protein 2 (colonic epithelium-enriched)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xp11.23
Summary	This gene encodes an integral membrane protein that localizes to the endoplasmic reticulum in colonic epithelial cells. The encoded protein can multimerize and may function as an ion channel. A polymorphism in the promoter of this gene may be linked to an increased risk of X-linked cognitive disability. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Jan 2010].
Disorder MIM:	300112

mRNA and Protein(s)

mRNA	Protein	Name
NM_002668.2	NP_002659.1	proteolipid protein 2
NM_002668.3	NP_002659.1	proteolipid protein 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	PLP2	NP_002659.1
Bos taurus (cattle)	PLP2	NP_976239.1
Xenopus tropicalis (tropical clawed frog)	plp2	NP_001037892.1
	PLP2	XP_001106080.1
Canis lupus familiaris (dog)	PLP2	XP_005642144.1
Mus musculus (house mouse)	Plp2	NP_062729.1
Danio rerio (zebrafish)	plp2	NP_001154917.1
Rattus norvegicus (Norway rat)	Plp2	NP_997484.1

Gene Ontology
Bibliography

Related articles in PubMed

Loss of MiR-664 Expression Enhances Cutaneous Malignant Melanoma Proliferation by Upregulating PLP2.
Ding Z, Jian S, Peng X, Liu Y, Wang J, Zheng L, Ou C, Wang Y, Zeng W, Zhou M
Medicine94(33)e1327(2015 Aug)

miR-664 negatively regulates PLP2 and promotes cell proliferation and invasion in T-cell acute lymphoblastic leukaemia.
Zhu H, Miao MH, Ji XQ, Xue J, Shao XJ
Biochemical and biophysical research communications459(2)340-5(2015 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PLP2 specifically binds to phosphatidylinositol 3 kinase to activate the protein kinase B pathway to enhance cell proliferation, adhesion, and invasion in melanoma cells.
Title: Loss of MiR-664 Expression Enhances Cutaneous Malignant Melanoma Proliferation by Upregulating PLP2.

miR-664 negatively regulates PLP2 and promotes proliferation and invasion of T-ALL cell lines. Thus, miR-664 may represent a potential therapeutic target for T-ALL intervention.
Title: miR-664 negatively regulates PLP2 and promotes cell proliferation and invasion in T-cell acute lymphoblastic leukaemia.

PLP2 and RAB5C are binding partners of TPD52.
Title: Identification of PLP2 and RAB5C as novel TPD52 binding partners through yeast two-hybrid screening.

This work ascribes a critical function to PLP2 for viral ligase activity and underlines the power of non-lethal haploid genetic screens in human cells to identify the genes involved in pathogen manipulation of the host immune system.
Title: Haploid genetic screens identify an essential role for PLP2 in the downregulation of novel plasma membrane targets by viral E3 ubiquitin ligases.

PLP2 is expressed abundantly in the pyramidal cells of hippocampus and granular cells of the cerebellum in the brains of a cohort of males with probable X-linked mental retardation.
Title: X chromosome cDNA microarray screening identifies a functional PLP2 promoter polymorphism enriched in patients with X-linked mental retardation.

The following PLP2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PLP2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23205	NM_002668.3 Latest version!	Homo sapiens proteolipid protein 2 (PLP2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OHu23205	NM_002668.2	Homo sapiens proteolipid protein 2 (PLP2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PLP2 ( NM_002668.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002659.1 Homo sapiens proteolipid protein 2 (PLP2), mRNA.

Price & Availability↑

CloneID	OHu23205
Clone ID Related Accession (Same CDS sequence)	NM_002668.2 , NM_002668.3
Accession Version	NM_002668.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	proteolipid protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB220888.1, BC109066.2 and AC232271.2. This sequence is a reference standard in the RefSeqGene project. On Jan 21, 2010 this sequence version replaced NM_002668.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: ERR279844.1704.1, SRR1163657.165379.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGATT CTGAGCGCCT CTCGGCTCCT GGCTGCTGGG CCGCCTGCAC CAACTTCTCG 
CGCACTCGAA AGGGAATCCT CCTGTTTGCT GAGATTATAT TATGCCTGGT GATCCTGATC 
TGCTTCAGTG CCTCCACACC AGGCTACTCC TCCCTGTCGG TGATTGAGAT GATCCTTGCT 
GCTATTTTCT TTGTTGTCTA CATGTGTGAC CTGCACACCA AGATACCATT CATCAACTGG 
CCCTGGAGTG ATTTCTTCCG AACCCTCATA GCGGCAATCC TCTACCTGAT CACCTCCATT 
GTTGTCCTTG TTGAGAGAGG AAACCACTCC AAAATCGTCG CAGGGGTACT GGGCCTAATC 
GCTACGTGCC TCTTTGGCTA TGATGCCTAT GTCACCTTCC CCGTTCGGCA GCCAAGACAT 
ACAGCAGCCC CCACTGACCC CGCAGATGGC CCGGTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002659.1
CDS	165..623
Translation	MADSERLSAPGCWAACTNFSRTRKGILLFAEIILCLVILICFSASTPGYSSLSVIEMILAAIFFVVYMCDLHTKIPFINWPWSDFFRTLIAAILYLITSIVVLVERGNHSKIVAGVLGLIATCLFGYDAYVTFPVRQPRHTAAPTDPADGPV

Target ORF information:

RefSeq Version	NM_002668.2
Organism	Homo sapiens(human)
Definition	Homo sapiens proteolipid protein 2 (PLP2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002668.2

ORF Insert Sequence:

ATGGCGGATT CTGAGCGCCT CTCGGCTCCT GGCTGCTGGG CCGCCTGCAC CAACTTCTCG 
CGCACTCGAA AGGGAATCCT CCTGTTTGCT GAGATTATAT TATGCCTGGT GATCCTGATC 
TGCTTCAGTG CCTCCACACC AGGCTACTCC TCCCTGTCGG TGATTGAGAT GATCCTTGCT 
GCTATTTTCT TTGTTGTCTA CATGTGTGAC CTGCACACCA AGATACCATT CATCAACTGG 
CCCTGGAGTG ATTTCTTCCG AACCCTCATA GCGGCAATCC TCTACCTGAT CACCTCCATT 
GTTGTCCTTG TTGAGAGAGG AAACCACTCC AAAATCGTCG CAGGGGTACT GGGCCTAATC 
GCTACGTGCC TCTTTGGCTA TGATGCCTAT GTCACCTTCC CCGTTCGGCA GCCAAGACAT 
ACAGCAGCCC CCACTGACCC CGCAGATGGC CCGGTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PLP2 ( NM_002668.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002659.1 Homo sapiens proteolipid protein 2 (PLP2), mRNA.

Price & Availability↑

CloneID	OHu23205
Clone ID Related Accession (Same CDS sequence)	NM_002668.2 , NM_002668.3
Accession Version	NM_002668.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-02
Organism	Homo sapiens(human)
Product	proteolipid protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB220888.1, BC109066.2 and AC232271.2. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_002668.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279848.8144.1, SRR5189658.107344.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000376327.6/ ENSP00000365505.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGATT CTGAGCGCCT CTCGGCTCCT GGCTGCTGGG CCGCCTGCAC CAACTTCTCG 
CGCACTCGAA AGGGAATCCT CCTGTTTGCT GAGATTATAT TATGCCTGGT GATCCTGATC 
TGCTTCAGTG CCTCCACACC AGGCTACTCC TCCCTGTCGG TGATTGAGAT GATCCTTGCT 
GCTATTTTCT TTGTTGTCTA CATGTGTGAC CTGCACACCA AGATACCATT CATCAACTGG 
CCCTGGAGTG ATTTCTTCCG AACCCTCATA GCGGCAATCC TCTACCTGAT CACCTCCATT 
GTTGTCCTTG TTGAGAGAGG AAACCACTCC AAAATCGTCG CAGGGGTACT GGGCCTAATC 
GCTACGTGCC TCTTTGGCTA TGATGCCTAT GTCACCTTCC CCGTTCGGCA GCCAAGACAT 
ACAGCAGCCC CCACTGACCC CGCAGATGGC CCGGTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002659.1
CDS	104..562
Translation	MADSERLSAPGCWAACTNFSRTRKGILLFAEIILCLVILICFSASTPGYSSLSVIEMILAAIFFVVYMCDLHTKIPFINWPWSDFFRTLIAAILYLITSIVVLVERGNHSKIVAGVLGLIATCLFGYDAYVTFPVRQPRHTAAPTDPADGPV

Target ORF information:

RefSeq Version	NM_002668.3
Organism	Homo sapiens(human)
Definition	Homo sapiens proteolipid protein 2 (PLP2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002668.3

ORF Insert Sequence:

ATGGCGGATT CTGAGCGCCT CTCGGCTCCT GGCTGCTGGG CCGCCTGCAC CAACTTCTCG 
CGCACTCGAA AGGGAATCCT CCTGTTTGCT GAGATTATAT TATGCCTGGT GATCCTGATC 
TGCTTCAGTG CCTCCACACC AGGCTACTCC TCCCTGTCGG TGATTGAGAT GATCCTTGCT 
GCTATTTTCT TTGTTGTCTA CATGTGTGAC CTGCACACCA AGATACCATT CATCAACTGG 
CCCTGGAGTG ATTTCTTCCG AACCCTCATA GCGGCAATCC TCTACCTGAT CACCTCCATT 
GTTGTCCTTG TTGAGAGAGG AAACCACTCC AAAATCGTCG CAGGGGTACT GGGCCTAATC 
GCTACGTGCC TCTTTGGCTA TGATGCCTAT GTCACCTTCC CCGTTCGGCA GCCAAGACAT 
ACAGCAGCCC CCACTGACCC CGCAGATGGC CCGGTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Loss of MiR-664 Expression Enhances Cutaneous Malignant Melanoma Proliferation by Upregulating PLP2.
Medicine94(33)e1327(2015 Aug)
Ding Z,Jian S,Peng X,Liu Y,Wang J,Zheng L,Ou C,Wang Y,Zeng W,Zhou M

miR-664 negatively regulates PLP2 and promotes cell proliferation and invasion in T-cell acute lymphoblastic leukaemia.
Biochemical and biophysical research communications459(2)340-5(2015 Apr)
Zhu H,Miao MH,Ji XQ,Xue J,Shao XJ