PLP1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PLP1
Entrez Gene ID	5354
Full Name	proteolipid protein 1
Synonyms	GPM6C,HLD1,MMPL,PLP,PLP/DM20,PMD,SPG2
General protein information	Preferred Names proteolipid protein 1 Names myelin proteolipid protein lipophilin major myelin proteolipid protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq22.2
Summary	This gene encodes a transmembrane proteolipid protein that is the predominant component of myelin. The encoded protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively splicing results in multiple transcript variants, including the DM20 splice variant. [provided by RefSeq, Feb 2015].
Disorder MIM:	300401
Disorder Html:	Pelizaeus-Merzbacher disease, 312080 (3); Spastic paraplegia 2, X-linked, 312920 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001128834.2	NP_001122306.1	myelin proteolipid protein isoform 1
NM_199478.3	NP_955772.1	myelin proteolipid protein isoform 2
NM_000533.5	NP_000524.3	myelin proteolipid protein isoform 1
NM_001305004.1	NP_001291933.1	myelin proteolipid protein isoform 3
NM_199478.2	NP_955772.1	myelin proteolipid protein isoform 2
NM_000533.4	NP_000524.3	myelin proteolipid protein isoform 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PLP1	XP_001141683.1
Canis lupus familiaris (dog)	PLP1	NP_001013856.1
Bos taurus (cattle)	PLP1	NP_776574.2
Homo sapiens (human)	PLP1	NP_000524.3
Gallus gallus (chicken)	PLP1	NP_990608.1
	PLP1	XP_001087984.2
Mus musculus (house mouse)	Plp1	NP_035253.1
Rattus norvegicus (Norway rat)	Plp1	NP_112252.1
Xenopus tropicalis (tropical clawed frog)	plp1	NP_001027507.1

Gene Ontology
Bibliography

Related articles in PubMed

Effects of Intron 1 Sequences on Human PLP1 Expression: Implications for PLP1-Related Disorders.
Wight PA
ASN neuro9(4)1759091417720583(2017 Jul-Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Review focusing on sequences in hPLP1 intron 1 DNA deemed important for hPLP1 gene activity as well as a couple of "human-specific" supplementary exons within the first intron which are utilized to generate novel splice variants, and the potential role that these sequences may play in PLP1-linked disorders.
Title: Effects of Intron 1 Sequences on Human PLP1 Expression: Implications for PLP1-Related Disorders.

Human induced pluripotent stem cells-derived oligodendrocytes from 12 individuals with Pelizaeus-Merzbacher and identified individual and shared defects in PLP1 mRNA expression and splicing, oligodendrocyte progenitor development, and oligodendrocyte morphology and capacity for myelination.
Title: Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes.

report a novel mutation of the PLP1 gene in two siblings with Pelizaeus-Merzbacher disease associated with a rare and protean neuroimaging finding of optic nerve enlargement
Title: A novel PLP1 mutation associated with optic nerve enlargement in two siblings with Pelizaeus-Merzbacher disease: A new MRI finding.

it seems that the epitopes of some microorganisms mimicking PLP such as PLP58-74 might have a potential role in the initiation of Multiple Sclerosis.
Title: Association of New Putative Epitopes of Myelin Proteolipid Protein (58-74) with Pathogenesis of Multiple Sclerosis.

Insertion of an extra copy of Xq22.2 into 1p36 results in functional duplication of the PLP1 gene in a girl with classical Pelizaeus-Merzbacher disease.
Title: Insertion of an extra copy of Xq22.2 into 1p36 results in functional duplication of the PLP1 gene in a girl with classical Pelizaeus-Merzbacher disease.

The following PLP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PLP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25924	NM_001128834.2 Latest version!	Homo sapiens proteolipid protein 1 (PLP1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu25924	NM_000533.5 Latest version!	Homo sapiens proteolipid protein 1 (PLP1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu26001	NM_199478.3 Latest version!	Homo sapiens proteolipid protein 1 (PLP1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu59783	NM_001305004.1 Latest version!	Homo sapiens proteolipid protein 1 (PLP1), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu26001	NM_199478.2	Homo sapiens proteolipid protein 1 (PLP1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu25924	NM_000533.4	Homo sapiens proteolipid protein 1 (PLP1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PLP1 ( NM_001128834.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001122306.1 Homo sapiens proteolipid protein 1 (PLP1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu25924
Clone ID Related Accession (Same CDS sequence)	NM_001128834.2 , NM_000533.5 , NM_000533.4
Accession Version	NM_001128834.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 834bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	myelin proteolipid protein isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC342197.1, AK292728.1 and BC095452.1. This sequence is a reference standard in the RefSeqGene project. On Jan 7, 2015 this sequence version replaced NM_001128834.1. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK292728.1, SRR1803611.87040.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145245, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCTTGT TAGAGTGCTG TGCAAGATGT CTGGTAGGGG CCCCCTTTGC TTCCCTGGTG 
GCCACTGGAT TGTGTTTCTT TGGGGTGGCA CTGTTCTGTG GCTGTGGACA TGAAGCCCTC 
ACTGGCACAG AAAAGCTAAT TGAGACCTAT TTCTCCAAAA ACTACCAAGA CTATGAGTAT 
CTCATCAATG TGATCCATGC CTTCCAGTAT GTCATCTATG GAACTGCCTC TTTCTTCTTC 
CTTTATGGGG CCCTCCTGCT GGCTGAGGGC TTCTACACCA CCGGCGCAGT CAGGCAGATC 
TTTGGCGACT ACAAGACCAC CATCTGCGGC AAGGGCCTGA GCGCAACGGT AACAGGGGGC 
CAGAAGGGGA GGGGTTCCAG AGGCCAACAT CAAGCTCATT CTTTGGAGCG GGTGTGTCAT 
TGTTTGGGAA AATGGCTAGG ACATCCCGAC AAGTTTGTGG GCATCACCTA TGCCCTGACC 
GTTGTGTGGC TCCTGGTGTT TGCCTGCTCT GCTGTGCCTG TGTACATTTA CTTCAACACC 
TGGACCACCT GCCAGTCTAT TGCCTTCCCC AGCAAGACCT CTGCCAGTAT AGGCAGTCTC 
TGTGCTGATG CCAGAATGTA TGGTGTTCTC CCATGGAATG CTTTCCCTGG CAAGGTTTGT 
GGCTCCAACC TTCTGTCCAT CTGCAAAACA GCTGAGTTCC AAATGACCTT CCACCTGTTT 
ATTGCTGCAT TTGTGGGGGC TGCAGCTACA CTGGTTTCCC TGCTCACCTT CATGATTGCT 
GCCACTTACA ACTTTGCCGT CCTTAAACTC ATGGGCCGAG GCACCAAGTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001122306.1
CDS	286..1119
Translation	MGLLECCARCLVGAPFASLVATGLCFFGVALFCGCGHEALTGTEKLIETYFSKNYQDYEYLINVIHAFQYVIYGTASFFFLYGALLLAEGFYTTGAVRQIFGDYKTTICGKGLSATVTGGQKGRGSRGQHQAHSLERVCHCLGKWLGHPDKFVGITYALTVVWLLVFACSAVPVYIYFNTWTTCQSIAFPSKTSASIGSLCADARMYGVLPWNAFPGKVCGSNLLSICKTAEFQMTFHLFIAAFVGAAATLVSLLTFMIAATYNFAVLKLMGRGTKF

Target ORF information:

RefSeq Version	NM_001128834.2
Organism	Homo sapiens(human)
Definition	Homo sapiens proteolipid protein 1 (PLP1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001128834.2

ORF Insert Sequence:

ATGGGCTTGT TAGAGTGCTG TGCAAGATGT CTGGTAGGGG CCCCCTTTGC TTCCCTGGTG 
GCCACTGGAT TGTGTTTCTT TGGGGTGGCA CTGTTCTGTG GCTGTGGACA TGAAGCCCTC 
ACTGGCACAG AAAAGCTAAT TGAGACCTAT TTCTCCAAAA ACTACCAAGA CTATGAGTAT 
CTCATCAATG TGATCCATGC CTTCCAGTAT GTCATCTATG GAACTGCCTC TTTCTTCTTC 
CTTTATGGGG CCCTCCTGCT GGCTGAGGGC TTCTACACCA CCGGCGCAGT CAGGCAGATC 
TTTGGCGACT ACAAGACCAC CATCTGCGGC AAGGGCCTGA GCGCAACGGT AACAGGGGGC 
CAGAAGGGGA GGGGTTCCAG AGGCCAACAT CAAGCTCATT CTTTGGAGCG GGTGTGTCAT 
TGTTTGGGAA AATGGCTAGG ACATCCCGAC AAGTTTGTGG GCATCACCTA TGCCCTGACC 
GTTGTGTGGC TCCTGGTGTT TGCCTGCTCT GCTGTGCCTG TGTACATTTA CTTCAACACC 
TGGACCACCT GCCAGTCTAT TGCCTTCCCC AGCAAGACCT CTGCCAGTAT AGGCAGTCTC 
TGTGCTGATG CCAGAATGTA TGGTGTTCTC CCATGGAATG CTTTCCCTGG CAAGGTTTGT 
GGCTCCAACC TTCTGTCCAT CTGCAAAACA GCTGAGTTCC AAATGACCTT CCACCTGTTT 
ATTGCTGCAT TTGTGGGGGC TGCAGCTACA CTGGTTTCCC TGCTCACCTT CATGATTGCT 
GCCACTTACA ACTTTGCCGT CCTTAAACTC ATGGGCCGAG GCACCAAGTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PLP1 ( NM_000533.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_000524.3 Homo sapiens proteolipid protein 1 (PLP1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu25924
Clone ID Related Accession (Same CDS sequence)	NM_001128834.2 , NM_000533.5 , NM_000533.4
Accession Version	NM_000533.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 834bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	myelin proteolipid protein isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA299940.1, AK292728.1 and BC095452.1. On Nov 23, 2018 this sequence version replaced NM_000533.4. Transcript Variant: This variant (1, also known as PLP) encodes the longest isoform (1). Variants 1 and 3 encode the same isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.1043899.1, SRR3476690.844864.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000621218.5/ ENSP00000484450.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGCTTGT TAGAGTGCTG TGCAAGATGT CTGGTAGGGG CCCCCTTTGC TTCCCTGGTG 
GCCACTGGAT TGTGTTTCTT TGGGGTGGCA CTGTTCTGTG GCTGTGGACA TGAAGCCCTC 
ACTGGCACAG AAAAGCTAAT TGAGACCTAT TTCTCCAAAA ACTACCAAGA CTATGAGTAT 
CTCATCAATG TGATCCATGC CTTCCAGTAT GTCATCTATG GAACTGCCTC TTTCTTCTTC 
CTTTATGGGG CCCTCCTGCT GGCTGAGGGC TTCTACACCA CCGGCGCAGT CAGGCAGATC 
TTTGGCGACT ACAAGACCAC CATCTGCGGC AAGGGCCTGA GCGCAACGGT AACAGGGGGC 
CAGAAGGGGA GGGGTTCCAG AGGCCAACAT CAAGCTCATT CTTTGGAGCG GGTGTGTCAT 
TGTTTGGGAA AATGGCTAGG ACATCCCGAC AAGTTTGTGG GCATCACCTA TGCCCTGACC 
GTTGTGTGGC TCCTGGTGTT TGCCTGCTCT GCTGTGCCTG TGTACATTTA CTTCAACACC 
TGGACCACCT GCCAGTCTAT TGCCTTCCCC AGCAAGACCT CTGCCAGTAT AGGCAGTCTC 
TGTGCTGATG CCAGAATGTA TGGTGTTCTC CCATGGAATG CTTTCCCTGG CAAGGTTTGT 
GGCTCCAACC TTCTGTCCAT CTGCAAAACA GCTGAGTTCC AAATGACCTT CCACCTGTTT 
ATTGCTGCAT TTGTGGGGGC TGCAGCTACA CTGGTTTCCC TGCTCACCTT CATGATTGCT 
GCCACTTACA ACTTTGCCGT CCTTAAACTC ATGGGCCGAG GCACCAAGTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000524.3
CDS	157..990
Translation	MGLLECCARCLVGAPFASLVATGLCFFGVALFCGCGHEALTGTEKLIETYFSKNYQDYEYLINVIHAFQYVIYGTASFFFLYGALLLAEGFYTTGAVRQIFGDYKTTICGKGLSATVTGGQKGRGSRGQHQAHSLERVCHCLGKWLGHPDKFVGITYALTVVWLLVFACSAVPVYIYFNTWTTCQSIAFPSKTSASIGSLCADARMYGVLPWNAFPGKVCGSNLLSICKTAEFQMTFHLFIAAFVGAAATLVSLLTFMIAATYNFAVLKLMGRGTKF

Target ORF information:

RefSeq Version	NM_000533.5
Organism	Homo sapiens(human)
Definition	Homo sapiens proteolipid protein 1 (PLP1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000533.5

ORF Insert Sequence:

ATGGGCTTGT TAGAGTGCTG TGCAAGATGT CTGGTAGGGG CCCCCTTTGC TTCCCTGGTG 
GCCACTGGAT TGTGTTTCTT TGGGGTGGCA CTGTTCTGTG GCTGTGGACA TGAAGCCCTC 
ACTGGCACAG AAAAGCTAAT TGAGACCTAT TTCTCCAAAA ACTACCAAGA CTATGAGTAT 
CTCATCAATG TGATCCATGC CTTCCAGTAT GTCATCTATG GAACTGCCTC TTTCTTCTTC 
CTTTATGGGG CCCTCCTGCT GGCTGAGGGC TTCTACACCA CCGGCGCAGT CAGGCAGATC 
TTTGGCGACT ACAAGACCAC CATCTGCGGC AAGGGCCTGA GCGCAACGGT AACAGGGGGC 
CAGAAGGGGA GGGGTTCCAG AGGCCAACAT CAAGCTCATT CTTTGGAGCG GGTGTGTCAT 
TGTTTGGGAA AATGGCTAGG ACATCCCGAC AAGTTTGTGG GCATCACCTA TGCCCTGACC 
GTTGTGTGGC TCCTGGTGTT TGCCTGCTCT GCTGTGCCTG TGTACATTTA CTTCAACACC 
TGGACCACCT GCCAGTCTAT TGCCTTCCCC AGCAAGACCT CTGCCAGTAT AGGCAGTCTC 
TGTGCTGATG CCAGAATGTA TGGTGTTCTC CCATGGAATG CTTTCCCTGG CAAGGTTTGT 
GGCTCCAACC TTCTGTCCAT CTGCAAAACA GCTGAGTTCC AAATGACCTT CCACCTGTTT 
ATTGCTGCAT TTGTGGGGGC TGCAGCTACA CTGGTTTCCC TGCTCACCTT CATGATTGCT 
GCCACTTACA ACTTTGCCGT CCTTAAACTC ATGGGCCGAG GCACCAAGTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PLP1 ( NM_000533.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000524.3 Homo sapiens proteolipid protein 1 (PLP1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu25924
Clone ID Related Accession (Same CDS sequence)	NM_001128834.2 , NM_000533.5 , NM_000533.4
Accession Version	NM_000533.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 834bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-10
Organism	Homo sapiens(human)
Product	myelin proteolipid protein isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA299940.1, AK292728.1 and BC095452.1. On Jan 7, 2015 this sequence version replaced NM_000533.3. Transcript Variant: This variant (1, also known as PLP) encodes the longest isoform (1). Variants 1 and 3 encode the same isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.199202.1, AK128782.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCTTGT TAGAGTGCTG TGCAAGATGT CTGGTAGGGG CCCCCTTTGC TTCCCTGGTG 
GCCACTGGAT TGTGTTTCTT TGGGGTGGCA CTGTTCTGTG GCTGTGGACA TGAAGCCCTC 
ACTGGCACAG AAAAGCTAAT TGAGACCTAT TTCTCCAAAA ACTACCAAGA CTATGAGTAT 
CTCATCAATG TGATCCATGC CTTCCAGTAT GTCATCTATG GAACTGCCTC TTTCTTCTTC 
CTTTATGGGG CCCTCCTGCT GGCTGAGGGC TTCTACACCA CCGGCGCAGT CAGGCAGATC 
TTTGGCGACT ACAAGACCAC CATCTGCGGC AAGGGCCTGA GCGCAACGGT AACAGGGGGC 
CAGAAGGGGA GGGGTTCCAG AGGCCAACAT CAAGCTCATT CTTTGGAGCG GGTGTGTCAT 
TGTTTGGGAA AATGGCTAGG ACATCCCGAC AAGTTTGTGG GCATCACCTA TGCCCTGACC 
GTTGTGTGGC TCCTGGTGTT TGCCTGCTCT GCTGTGCCTG TGTACATTTA CTTCAACACC 
TGGACCACCT GCCAGTCTAT TGCCTTCCCC AGCAAGACCT CTGCCAGTAT AGGCAGTCTC 
TGTGCTGATG CCAGAATGTA TGGTGTTCTC CCATGGAATG CTTTCCCTGG CAAGGTTTGT 
GGCTCCAACC TTCTGTCCAT CTGCAAAACA GCTGAGTTCC AAATGACCTT CCACCTGTTT 
ATTGCTGCAT TTGTGGGGGC TGCAGCTACA CTGGTTTCCC TGCTCACCTT CATGATTGCT 
GCCACTTACA ACTTTGCCGT CCTTAAACTC ATGGGCCGAG GCACCAAGTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000524.3
CDS	204..1037
Translation	MGLLECCARCLVGAPFASLVATGLCFFGVALFCGCGHEALTGTEKLIETYFSKNYQDYEYLINVIHAFQYVIYGTASFFFLYGALLLAEGFYTTGAVRQIFGDYKTTICGKGLSATVTGGQKGRGSRGQHQAHSLERVCHCLGKWLGHPDKFVGITYALTVVWLLVFACSAVPVYIYFNTWTTCQSIAFPSKTSASIGSLCADARMYGVLPWNAFPGKVCGSNLLSICKTAEFQMTFHLFIAAFVGAAATLVSLLTFMIAATYNFAVLKLMGRGTKF

Target ORF information:

RefSeq Version	NM_000533.4
Organism	Homo sapiens(human)
Definition	Homo sapiens proteolipid protein 1 (PLP1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000533.4

ORF Insert Sequence:

ATGGGCTTGT TAGAGTGCTG TGCAAGATGT CTGGTAGGGG CCCCCTTTGC TTCCCTGGTG 
GCCACTGGAT TGTGTTTCTT TGGGGTGGCA CTGTTCTGTG GCTGTGGACA TGAAGCCCTC 
ACTGGCACAG AAAAGCTAAT TGAGACCTAT TTCTCCAAAA ACTACCAAGA CTATGAGTAT 
CTCATCAATG TGATCCATGC CTTCCAGTAT GTCATCTATG GAACTGCCTC TTTCTTCTTC 
CTTTATGGGG CCCTCCTGCT GGCTGAGGGC TTCTACACCA CCGGCGCAGT CAGGCAGATC 
TTTGGCGACT ACAAGACCAC CATCTGCGGC AAGGGCCTGA GCGCAACGGT AACAGGGGGC 
CAGAAGGGGA GGGGTTCCAG AGGCCAACAT CAAGCTCATT CTTTGGAGCG GGTGTGTCAT 
TGTTTGGGAA AATGGCTAGG ACATCCCGAC AAGTTTGTGG GCATCACCTA TGCCCTGACC 
GTTGTGTGGC TCCTGGTGTT TGCCTGCTCT GCTGTGCCTG TGTACATTTA CTTCAACACC 
TGGACCACCT GCCAGTCTAT TGCCTTCCCC AGCAAGACCT CTGCCAGTAT AGGCAGTCTC 
TGTGCTGATG CCAGAATGTA TGGTGTTCTC CCATGGAATG CTTTCCCTGG CAAGGTTTGT 
GGCTCCAACC TTCTGTCCAT CTGCAAAACA GCTGAGTTCC AAATGACCTT CCACCTGTTT 
ATTGCTGCAT TTGTGGGGGC TGCAGCTACA CTGGTTTCCC TGCTCACCTT CATGATTGCT 
GCCACTTACA ACTTTGCCGT CCTTAAACTC ATGGGCCGAG GCACCAAGTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PLP1 ( NM_199478.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_955772.1 Homo sapiens proteolipid protein 1 (PLP1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu26001
Clone ID Related Accession (Same CDS sequence)	NM_199478.3 , NM_199478.2
Accession Version	NM_199478.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 729bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-20
Organism	Homo sapiens(human)
Product	myelin proteolipid protein isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA299940.1, AK292728.1 and BC095452.1. On May 31, 2019 this sequence version replaced NM_199478.2. Transcript Variant: This variant (2, also known as DM20) uses an alternate in-frame donor splice site compared to variant 1. It encodes a shorter isoform (2) than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7410570.691996.1, SRR3476690.761496.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCTTGT TAGAGTGCTG TGCAAGATGT CTGGTAGGGG CCCCCTTTGC TTCCCTGGTG 
GCCACTGGAT TGTGTTTCTT TGGGGTGGCA CTGTTCTGTG GCTGTGGACA TGAAGCCCTC 
ACTGGCACAG AAAAGCTAAT TGAGACCTAT TTCTCCAAAA ACTACCAAGA CTATGAGTAT 
CTCATCAATG TGATCCATGC CTTCCAGTAT GTCATCTATG GAACTGCCTC TTTCTTCTTC 
CTTTATGGGG CCCTCCTGCT GGCTGAGGGC TTCTACACCA CCGGCGCAGT CAGGCAGATC 
TTTGGCGACT ACAAGACCAC CATCTGCGGC AAGGGCCTGA GCGCAACGTT TGTGGGCATC 
ACCTATGCCC TGACCGTTGT GTGGCTCCTG GTGTTTGCCT GCTCTGCTGT GCCTGTGTAC 
ATTTACTTCA ACACCTGGAC CACCTGCCAG TCTATTGCCT TCCCCAGCAA GACCTCTGCC 
AGTATAGGCA GTCTCTGTGC TGATGCCAGA ATGTATGGTG TTCTCCCATG GAATGCTTTC 
CCTGGCAAGG TTTGTGGCTC CAACCTTCTG TCCATCTGCA AAACAGCTGA GTTCCAAATG 
ACCTTCCACC TGTTTATTGC TGCATTTGTG GGGGCTGCAG CTACACTGGT TTCCCTGCTC 
ACCTTCATGA TTGCTGCCAC TTACAACTTT GCCGTCCTTA AACTCATGGG CCGAGGCACC 
AAGTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_955772.1
CDS	157..885
Translation	MGLLECCARCLVGAPFASLVATGLCFFGVALFCGCGHEALTGTEKLIETYFSKNYQDYEYLINVIHAFQYVIYGTASFFFLYGALLLAEGFYTTGAVRQIFGDYKTTICGKGLSATFVGITYALTVVWLLVFACSAVPVYIYFNTWTTCQSIAFPSKTSASIGSLCADARMYGVLPWNAFPGKVCGSNLLSICKTAEFQMTFHLFIAAFVGAAATLVSLLTFMIAATYNFAVLKLMGRGTKF

Target ORF information:

RefSeq Version	NM_199478.3
Organism	Homo sapiens(human)
Definition	Homo sapiens proteolipid protein 1 (PLP1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_199478.3

ORF Insert Sequence:

ATGGGCTTGT TAGAGTGCTG TGCAAGATGT CTGGTAGGGG CCCCCTTTGC TTCCCTGGTG 
GCCACTGGAT TGTGTTTCTT TGGGGTGGCA CTGTTCTGTG GCTGTGGACA TGAAGCCCTC 
ACTGGCACAG AAAAGCTAAT TGAGACCTAT TTCTCCAAAA ACTACCAAGA CTATGAGTAT 
CTCATCAATG TGATCCATGC CTTCCAGTAT GTCATCTATG GAACTGCCTC TTTCTTCTTC 
CTTTATGGGG CCCTCCTGCT GGCTGAGGGC TTCTACACCA CCGGCGCAGT CAGGCAGATC 
TTTGGCGACT ACAAGACCAC CATCTGCGGC AAGGGCCTGA GCGCAACGTT TGTGGGCATC 
ACCTATGCCC TGACCGTTGT GTGGCTCCTG GTGTTTGCCT GCTCTGCTGT GCCTGTGTAC 
ATTTACTTCA ACACCTGGAC CACCTGCCAG TCTATTGCCT TCCCCAGCAA GACCTCTGCC 
AGTATAGGCA GTCTCTGTGC TGATGCCAGA ATGTATGGTG TTCTCCCATG GAATGCTTTC 
CCTGGCAAGG TTTGTGGCTC CAACCTTCTG TCCATCTGCA AAACAGCTGA GTTCCAAATG 
ACCTTCCACC TGTTTATTGC TGCATTTGTG GGGGCTGCAG CTACACTGGT TTCCCTGCTC 
ACCTTCATGA TTGCTGCCAC TTACAACTTT GCCGTCCTTA AACTCATGGG CCGAGGCACC 
AAGTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PLP1 ( NM_199478.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_955772.1 Homo sapiens proteolipid protein 1 (PLP1), transcript variant 2, mRNA.

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CloneID	OHu26001
Clone ID Related Accession (Same CDS sequence)	NM_199478.3 , NM_199478.2
Accession Version	NM_199478.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 729bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	myelin proteolipid protein isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA299940.1, AK292728.1 and BC095452.1. On Jan 7, 2015 this sequence version replaced NM_199478.1. Transcript Variant: This variant (2, also known as DM20) uses an alternate in-frame donor splice site compared to variant 1. It encodes a shorter isoform (2) than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.56686.1, SRR1803615.186029.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCTTGT TAGAGTGCTG TGCAAGATGT CTGGTAGGGG CCCCCTTTGC TTCCCTGGTG 
GCCACTGGAT TGTGTTTCTT TGGGGTGGCA CTGTTCTGTG GCTGTGGACA TGAAGCCCTC 
ACTGGCACAG AAAAGCTAAT TGAGACCTAT TTCTCCAAAA ACTACCAAGA CTATGAGTAT 
CTCATCAATG TGATCCATGC CTTCCAGTAT GTCATCTATG GAACTGCCTC TTTCTTCTTC 
CTTTATGGGG CCCTCCTGCT GGCTGAGGGC TTCTACACCA CCGGCGCAGT CAGGCAGATC 
TTTGGCGACT ACAAGACCAC CATCTGCGGC AAGGGCCTGA GCGCAACGTT TGTGGGCATC 
ACCTATGCCC TGACCGTTGT GTGGCTCCTG GTGTTTGCCT GCTCTGCTGT GCCTGTGTAC 
ATTTACTTCA ACACCTGGAC CACCTGCCAG TCTATTGCCT TCCCCAGCAA GACCTCTGCC 
AGTATAGGCA GTCTCTGTGC TGATGCCAGA ATGTATGGTG TTCTCCCATG GAATGCTTTC 
CCTGGCAAGG TTTGTGGCTC CAACCTTCTG TCCATCTGCA AAACAGCTGA GTTCCAAATG 
ACCTTCCACC TGTTTATTGC TGCATTTGTG GGGGCTGCAG CTACACTGGT TTCCCTGCTC 
ACCTTCATGA TTGCTGCCAC TTACAACTTT GCCGTCCTTA AACTCATGGG CCGAGGCACC 
AAGTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_955772.1
CDS	204..932
Translation	MGLLECCARCLVGAPFASLVATGLCFFGVALFCGCGHEALTGTEKLIETYFSKNYQDYEYLINVIHAFQYVIYGTASFFFLYGALLLAEGFYTTGAVRQIFGDYKTTICGKGLSATFVGITYALTVVWLLVFACSAVPVYIYFNTWTTCQSIAFPSKTSASIGSLCADARMYGVLPWNAFPGKVCGSNLLSICKTAEFQMTFHLFIAAFVGAAATLVSLLTFMIAATYNFAVLKLMGRGTKF

Target ORF information:

RefSeq Version	NM_199478.2
Organism	Homo sapiens(human)
Definition	Homo sapiens proteolipid protein 1 (PLP1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_199478.2

ORF Insert Sequence:

ATGGGCTTGT TAGAGTGCTG TGCAAGATGT CTGGTAGGGG CCCCCTTTGC TTCCCTGGTG 
GCCACTGGAT TGTGTTTCTT TGGGGTGGCA CTGTTCTGTG GCTGTGGACA TGAAGCCCTC 
ACTGGCACAG AAAAGCTAAT TGAGACCTAT TTCTCCAAAA ACTACCAAGA CTATGAGTAT 
CTCATCAATG TGATCCATGC CTTCCAGTAT GTCATCTATG GAACTGCCTC TTTCTTCTTC 
CTTTATGGGG CCCTCCTGCT GGCTGAGGGC TTCTACACCA CCGGCGCAGT CAGGCAGATC 
TTTGGCGACT ACAAGACCAC CATCTGCGGC AAGGGCCTGA GCGCAACGTT TGTGGGCATC 
ACCTATGCCC TGACCGTTGT GTGGCTCCTG GTGTTTGCCT GCTCTGCTGT GCCTGTGTAC 
ATTTACTTCA ACACCTGGAC CACCTGCCAG TCTATTGCCT TCCCCAGCAA GACCTCTGCC 
AGTATAGGCA GTCTCTGTGC TGATGCCAGA ATGTATGGTG TTCTCCCATG GAATGCTTTC 
CCTGGCAAGG TTTGTGGCTC CAACCTTCTG TCCATCTGCA AAACAGCTGA GTTCCAAATG 
ACCTTCCACC TGTTTATTGC TGCATTTGTG GGGGCTGCAG CTACACTGGT TTCCCTGCTC 
ACCTTCATGA TTGCTGCCAC TTACAACTTT GCCGTCCTTA AACTCATGGG CCGAGGCACC 
AAGTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PLP1 ( NM_001305004.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001291933.1 Homo sapiens proteolipid protein 1 (PLP1), transcript variant 4, mRNA.

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CloneID	OHu59783
Clone ID Related Accession (Same CDS sequence)	NM_001305004.1
Accession Version	NM_001305004.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 669bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-20
Organism	Homo sapiens(human)
Product	myelin proteolipid protein isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC342996.1, AK295388.1, AK292728.1 and BC095452.1. Transcript Variant: This variant (4) has a shorter 5' UTR and uses an alternate in-frame acceptor site compared to variant 1. It encodes a shorter isoform (3) than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK295388.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142348, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACTATG AGTATCTCAT CAATGTGATC CATGCCTTCC AGTATGTCAT CTATGGAACT 
GCCTCTTTCT TCTTCCTTTA TGGGGCCCTC CTGCTGGCTG AGGGCTTCTA CACCACCGGC 
GCAGTCAGGC AGATCTTTGG CGACTACAAG ACCACCATCT GCGGCAAGGG CCTGAGCGCA 
ACGGTAACAG GGGGCCAGAA GGGGAGGGGT TCCAGAGGCC AACATCAAGC TCATTCTTTG 
GAGCGGGTGT GTCATTGTTT GGGAAAATGG CTAGGACATC CCGACAAGTT TGTGGGCATC 
ACCTATGCCC TGACCGTTGT GTGGCTCCTG GTGTTTGCCT GCTCTGCTGT GCCTGTGTAC 
ATTTACTTCA ACACCTGGAC CACCTGCCAG TCTATTGCCT TCCCCAGCAA GACCTCTGCC 
AGTATAGGCA GTCTCTGTGC TGATGCCAGA ATGTATGGTG TTCTCCCATG GAATGCTTTC 
CCTGGCAAGG TTTGTGGCTC CAACCTTCTG TCCATCTGCA AAACAGCTGA GTTCCAAATG 
ACCTTCCACC TGTTTATTGC TGCATTTGTG GGGGCTGCAG CTACACTGGT TTCCCTGCTC 
ACCTTCATGA TTGCTGCCAC TTACAACTTT GCCGTCCTTA AACTCATGGG CCGAGGCACC 
AAGTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001291933.1
CDS	144..812
Translation	MDYEYLINVIHAFQYVIYGTASFFFLYGALLLAEGFYTTGAVRQIFGDYKTTICGKGLSATVTGGQKGRGSRGQHQAHSLERVCHCLGKWLGHPDKFVGITYALTVVWLLVFACSAVPVYIYFNTWTTCQSIAFPSKTSASIGSLCADARMYGVLPWNAFPGKVCGSNLLSICKTAEFQMTFHLFIAAFVGAAATLVSLLTFMIAATYNFAVLKLMGRGTKF

Target ORF information:

RefSeq Version	NM_001305004.1
Organism	Homo sapiens(human)
Definition	Homo sapiens proteolipid protein 1 (PLP1), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001305004.1

ORF Insert Sequence:

ATGGACTATG AGTATCTCAT CAATGTGATC CATGCCTTCC AGTATGTCAT CTATGGAACT 
GCCTCTTTCT TCTTCCTTTA TGGGGCCCTC CTGCTGGCTG AGGGCTTCTA CACCACCGGC 
GCAGTCAGGC AGATCTTTGG CGACTACAAG ACCACCATCT GCGGCAAGGG CCTGAGCGCA 
ACGGTAACAG GGGGCCAGAA GGGGAGGGGT TCCAGAGGCC AACATCAAGC TCATTCTTTG 
GAGCGGGTGT GTCATTGTTT GGGAAAATGG CTAGGACATC CCGACAAGTT TGTGGGCATC 
ACCTATGCCC TGACCGTTGT GTGGCTCCTG GTGTTTGCCT GCTCTGCTGT GCCTGTGTAC 
ATTTACTTCA ACACCTGGAC CACCTGCCAG TCTATTGCCT TCCCCAGCAA GACCTCTGCC 
AGTATAGGCA GTCTCTGTGC TGATGCCAGA ATGTATGGTG TTCTCCCATG GAATGCTTTC 
CCTGGCAAGG TTTGTGGCTC CAACCTTCTG TCCATCTGCA AAACAGCTGA GTTCCAAATG 
ACCTTCCACC TGTTTATTGC TGCATTTGTG GGGGCTGCAG CTACACTGGT TTCCCTGCTC 
ACCTTCATGA TTGCTGCCAC TTACAACTTT GCCGTCCTTA AACTCATGGG CCGAGGCACC 
AAGTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Effects of Intron 1 Sequences on Human PLP1 Expression: Implications for PLP1-Related Disorders.
ASN neuro9(4)1759091417720583(2017 Jul-Aug)
Wight PA

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PLP1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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