Gene Symbol | BCL11A |
Entrez Gene ID | 53335 |
Full Name | B cell CLL/lymphoma 11A |
Synonyms | BCL11A-L,BCL11A-S,BCL11A-XL,BCL11a-M,CTIP1,DILOS,EVI9,HBFQTL5,ZNF856 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. |
Disorder MIM: | |
Disorder Html: | Dias-Logan syndrome, 617101 (3) |