PIN4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PIN4
Entrez Gene ID	5303
Full Name	peptidylprolyl cis/trans isomerase, NIMA-interacting 4
Synonyms	EPVH,PAR14,PAR17
General protein information	Preferred Names peptidylprolyl cis/trans isomerase, NIMA-interacting 4 Names peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 PPIase PIN4 eukaryotic parvulin homolog hEPVH hPar14 hPar17 parvulin parvulin-14 parvulin-17 peptidyl-prolyl cis-trans isomerase Pin4 peptidyl-prolyl cis/trans isomerase EPVH protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) rotamase PIN4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq13.1
Summary	This gene encodes a member of the parvulin subfamily of the peptidyl-prolyl cis/trans isomerase protein family. The encoded protein catalyzes the isomerization of peptidylprolyl bonds, and may play a role in the cell cycle, chromatin remodeling, and/or ribosome biogenesis. The encoded protein may play an additional role in the mitochondria. [provided by RefSeq, Dec 2009].
Disorder MIM:	300252

mRNA and Protein(s)

mRNA	Protein	Name
NM_001170747.1	NP_001164218.1	peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 isoform 2
NM_006223.3	NP_006214.2	peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 isoform 1
NM_006223.4	NP_006214.3	peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 isoform 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	LOC100687619	XP_005637763.1
Rattus norvegicus (Norway rat)	Pin4	XP_003752117.1
Gallus gallus (chicken)	PIN4	XP_004940635.1
Danio rerio (zebrafish)	pin4	NP_001018389.1
Drosophila melanogaster (fruit fly)	CG11858	NP_651364.1
Canis lupus familiaris (dog)	LOC102151798	XP_005632038.1
Canis lupus familiaris (dog)	PIN4	XP_005642155.1
Bos taurus (cattle)	PIN4	NP_001099127.1
Caenorhabditis elegans (roundworm)	Y48C3A.16	NP_496824.1
Neurospora crassa	NCU06433	XP_957324.2
Pan troglodytes (chimpanzee)	PIN4	XP_001139476.2
	PIN4	XP_001092957.1
Canis lupus familiaris (dog)	LOC100856504	XP_005639367.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP013296	XP_003436170.1
Magnaporthe oryzae (rice blast fungus)	MGG_17180	XP_003717082.1
Xenopus tropicalis (tropical clawed frog)	pin4	NP_989201.1
Homo sapiens (human)	PIN4	NP_006214.2
Mus musculus (house mouse)	Pin4	NP_081457.1

Gene Ontology
Bibliography

Related articles in PubMed

Parvulin 17-catalyzed Tubulin Polymerization Is Regulated by Calmodulin in a Calcium-dependent Manner.
Burgardt NI, Schmidt A, Manns A, Schutkowski A, Jahreis G, Lin YJ, Schulze B, Masch A, L?cke C, Weiwad M
The Journal of biological chemistry290(27)16708-22(2015 Jul)

Peroxide-mediated oxidation and inhibition of the peptidyl-prolyl isomerase Pin1.
Innes BT, Sowole MA, Gyenis L, Dubinsky M, Konermann L, Litchfield DW, Brandl CJ, Shilton BH
Biochimica et biophysica acta1852(5)905-12(2015 May)

Human DNA-binding peptidyl-prolyl cis/trans isomerase Par14 is cell cycle dependently expressed and associates with chromatin in vivo.
Saningong AD, Bayer P
BMC biochemistry164(2015 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Ca(2+)/Calmodulin binding to the N-terminal of Par17 causes steric hindrance of the Par17 active site, thus interfering with the Par17/tubulin interaction.
Title: Parvulin 17-catalyzed Tubulin Polymerization Is Regulated by Calmodulin in a Calcium-dependent Manner.

Data indicate that Pin1 prolyl isomerase active site cysteine, Cys113, is highly susceptible to oxidation.
Title: Peroxide-mediated oxidation and inhibition of the peptidyl-prolyl isomerase Pin1.

Par14 can be described as an endogenous non-histone chromatin protein, which binds DNA in vivo
Title: Human DNA-binding peptidyl-prolyl cis/trans isomerase Par14 is cell cycle dependently expressed and associates with chromatin in vivo.

Data indicate the association of Par14 with insulin receptor substrate 1 (IRS-1) in human HepG2 cells overexpressing both as well as endogenously in the mouse liver.
Title: Par14 protein associates with insulin receptor substrate 1 (IRS-1), thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions.

Identification of a longer Parvulin isoform (Par17) that has an extension at the 5' end including a 75 bp extended open reading frame.
Title: Characterization of novel elongated Parvulin isoforms that are ubiquitously expressed in human tissues and originate from alternative transcription initiation.

The following PIN4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PIN4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18209	NM_006223.3 Latest version!	Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 4 (PIN4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu09452	NM_001170747.1 Latest version!	Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 4 (PIN4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu107462	NM_006223.4 Latest version!	Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 4 (PIN4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PIN4 ( NM_006223.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006214.2 Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 4 (PIN4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18209
Clone ID Related Accession (Same CDS sequence)	NM_006223.3
Accession Version	NM_006223.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 471bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AU098526.1, AV709926.2, BC112281.1, BE504461.1, BC111394.1 and BU952002.1. This sequence is a reference standard in the RefSeqGene project. On Jan 1, 2010 this sequence version replaced NM_006223.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC070288.1, SRR1163658.371537.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 10364457, 17875217 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCCATGG CGGGGCTTCT AAAGGGGCTT GTACGGCAAC TGGAGCGGTT CAGCGTTCAA 
CAACAAGCTT CCAAGATGCC GCCCAAAGGA AAAAGTGGTT CTGGAAAAGC GGGGAAAGGG 
GGAGCAGCCT CTGGGAGTGA CAGTGCTGAC AAGAAGGCTC AAGGTCCCAA AGGTGGTGGC 
AATGCAGTAA AGGTCAGACA CATTCTATGT GAAAAACATG GCAAAATCAT GGAAGCCATG 
GAAAAGTTAA AGTCTGGGAT GAGATTCAAT GAAGTGGCCG CACAGTATAG TGAAGATAAA 
GCCAGGCAAG GGGGTGACTT GGGTTGGATG ACCAGAGGGT CCATGGTGGG ACCATTTCAA 
GAAGCAGCAT TTGCCTTGCC TGTAAGTGGG ATGGATAAGC CTGTGTTTAC AGACCCACCG 
GTTAAGACAA AATTTGGATA TCATATTATT ATGGTCGAAG GAAGAAAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006214.2
CDS	36..506
Translation	MPMAGLLKGLVRQLERFSVQQQASKMPPKGKSGSGKAGKGGAASGSDSADKKAQGPKGGGNAVKVRHILCEKHGKIMEAMEKLKSGMRFNEVAAQYSEDKARQGGDLGWMTRGSMVGPFQEAAFALPVSGMDKPVFTDPPVKTKFGYHIIMVEGRK

Target ORF information:

RefSeq Version	NM_006223.3
Organism	Homo sapiens(human)
Definition	Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 4 (PIN4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006223.3

ORF Insert Sequence:

ATGCCCATGG CGGGGCTTCT AAAGGGGCTT GTACGGCAAC TGGAGCGGTT CAGCGTTCAA 
CAACAAGCTT CCAAGATGCC GCCCAAAGGA AAAAGTGGTT CTGGAAAAGC GGGGAAAGGG 
GGAGCAGCCT CTGGGAGTGA CAGTGCTGAC AAGAAGGCTC AAGGTCCCAA AGGTGGTGGC 
AATGCAGTAA AGGTCAGACA CATTCTATGT GAAAAACATG GCAAAATCAT GGAAGCCATG 
GAAAAGTTAA AGTCTGGGAT GAGATTCAAT GAAGTGGCCG CACAGTATAG TGAAGATAAA 
GCCAGGCAAG GGGGTGACTT GGGTTGGATG ACCAGAGGGT CCATGGTGGG ACCATTTCAA 
GAAGCAGCAT TTGCCTTGCC TGTAAGTGGG ATGGATAAGC CTGTGTTTAC AGACCCACCG 
GTTAAGACAA AATTTGGATA TCATATTATT ATGGTCGAAG GAAGAAAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PIN4 ( NM_001170747.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001164218.1 Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 4 (PIN4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu09452
Clone ID Related Accession (Same CDS sequence)	NM_001170747.1
Accession Version	NM_001170747.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 402bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AU098526.1, AV709926.2 and AK127605.1. Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.27994.1, AK127605.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 10364457, 17875217 ##RefSeq-Attributes-END##

ATGCCCATGG CGGGGCTTCT AAAGGGGCTT GTACGGCAAC TGGAGCGGTT CAGCGTTCAA 
CAACAAGCTT CCAAGATGCC GCCCAAAGGA AAAAGTGGTT CTGGAAAAGC GGGGAAAGGG 
GGAGCAGCCT CTGGGAGTGA CAGTGCTGAC AAGAAGGCTC AAGGTCCCAA AGGTGGTGGC 
AATGCAGTAA AGGTCAGACA CATTCTATGT GAAAAACATG GCAAAATCAT GGAAGCCATG 
GAAAAGTTAA AGTCTGGGAT GAGATTCAAT GAAGTGGCCG CACAGTATAG TGAAGATAAA 
GCCAGGCAAG GGATTCCCAG CCTGCAGCAA CATGCTGGTC ACCATAGAGA CCTGAGAAGC 
ACCCTCATCT CATTGGTATC ATATTTACAA ACCACCCCTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001164218.1
CDS	36..437
Translation	MPMAGLLKGLVRQLERFSVQQQASKMPPKGKSGSGKAGKGGAASGSDSADKKAQGPKGGGNAVKVRHILCEKHGKIMEAMEKLKSGMRFNEVAAQYSEDKARQGIPSLQQHAGHHRDLRSTLISLVSYLQTTP

Target ORF information:

RefSeq Version	NM_001170747.1
Organism	Homo sapiens(human)
Definition	Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 4 (PIN4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001170747.1

ORF Insert Sequence:

ATGCCCATGG CGGGGCTTCT AAAGGGGCTT GTACGGCAAC TGGAGCGGTT CAGCGTTCAA 
CAACAAGCTT CCAAGATGCC GCCCAAAGGA AAAAGTGGTT CTGGAAAAGC GGGGAAAGGG 
GGAGCAGCCT CTGGGAGTGA CAGTGCTGAC AAGAAGGCTC AAGGTCCCAA AGGTGGTGGC 
AATGCAGTAA AGGTCAGACA CATTCTATGT GAAAAACATG GCAAAATCAT GGAAGCCATG 
GAAAAGTTAA AGTCTGGGAT GAGATTCAAT GAAGTGGCCG CACAGTATAG TGAAGATAAA 
GCCAGGCAAG GGATTCCCAG CCTGCAGCAA CATGCTGGTC ACCATAGAGA CCTGAGAAGC 
ACCCTCATCT CATTGGTATC ATATTTACAA ACCACCCCTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PIN4 ( NM_006223.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006214.3 Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 4 (PIN4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu107462
Clone ID Related Accession (Same CDS sequence)	NM_006223.4
Accession Version	NM_006223.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 396bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-25
Organism	Homo sapiens(human)
Product	peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AV709926.2, BC112281.1, BE504461.1 and AL135749.3. This sequence is a reference standard in the RefSeqGene project. On Dec 15, 2018 this sequence version replaced NM_006223.3. Transcript Variant: This variant (1) encodes isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. CCDS Note: The coding region has been updated to start at a downstream alternate in-frame start codon that is supported by conservation data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC111394.1, BC070288.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 10364457, 17875217 MANE Ensembl match :: ENST00000373669.8/ ENSP00000362773.3 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCGCCCA AAGGAAAAAG TGGTTCTGGA AAAGCGGGGA AAGGGGGAGC AGCCTCTGGG 
AGTGACAGTG CTGACAAGAA GGCTCAAGGT CCCAAAGGTG GTGGCAATGC AGTAAAGGTC 
AGACACATTC TATGTGAAAA ACATGGCAAA ATCATGGAAG CCATGGAAAA GTTAAAGTCT 
GGGATGAGAT TCAATGAAGT GGCCGCACAG TATAGTGAAG ATAAAGCCAG GCAAGGGGGT 
GACTTGGGTT GGATGACCAG AGGGTCCATG GTGGGACCAT TTCAAGAAGC AGCATTTGCC 
TTGCCTGTAA GTGGGATGGA TAAGCCTGTG TTTACAGACC CACCGGTTAA GACAAAATTT 
GGATATCATA TTATTATGGT CGAAGGAAGA AAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006214.3
CDS	30..425
Translation	MPPKGKSGSGKAGKGGAASGSDSADKKAQGPKGGGNAVKVRHILCEKHGKIMEAMEKLKSGMRFNEVAAQYSEDKARQGGDLGWMTRGSMVGPFQEAAFALPVSGMDKPVFTDPPVKTKFGYHIIMVEGRK

Target ORF information:

RefSeq Version	NM_006223.4
Organism	Homo sapiens(human)
Definition	Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 4 (PIN4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006223.4

ORF Insert Sequence:

ATGCCGCCCA AAGGAAAAAG TGGTTCTGGA AAAGCGGGGA AAGGGGGAGC AGCCTCTGGG 
AGTGACAGTG CTGACAAGAA GGCTCAAGGT CCCAAAGGTG GTGGCAATGC AGTAAAGGTC 
AGACACATTC TATGTGAAAA ACATGGCAAA ATCATGGAAG CCATGGAAAA GTTAAAGTCT 
GGGATGAGAT TCAATGAAGT GGCCGCACAG TATAGTGAAG ATAAAGCCAG GCAAGGGGGT 
GACTTGGGTT GGATGACCAG AGGGTCCATG GTGGGACCAT TTCAAGAAGC AGCATTTGCC 
TTGCCTGTAA GTGGGATGGA TAAGCCTGTG TTTACAGACC CACCGGTTAA GACAAAATTT 
GGATATCATA TTATTATGGT CGAAGGAAGA AAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Parvulin 17-catalyzed Tubulin Polymerization Is Regulated by Calmodulin in a Calcium-dependent Manner.
The Journal of biological chemistry290(27)16708-22(2015 Jul)
Burgardt NI,Schmidt A,Manns A,Schutkowski A,Jahreis G,Lin YJ,Schulze B,Masch A,L?cke C,Weiwad M

Peroxide-mediated oxidation and inhibition of the peptidyl-prolyl isomerase Pin1.
Biochimica et biophysica acta1852(5)905-12(2015 May)
Innes BT,Sowole MA,Gyenis L,Dubinsky M,Konermann L,Litchfield DW,Brandl CJ,Shilton BH

Human DNA-binding peptidyl-prolyl cis/trans isomerase Par14 is cell cycle dependently expressed and associates with chromatin in vivo.
BMC biochemistry164(2015 Feb)
Saningong AD,Bayer P

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PIN4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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