SERPINI1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SERPINI1
Entrez Gene ID	5274
Full Name	serpin family I member 1
Synonyms	PI12,neuroserpin
General protein information	Preferred Names serpin family I member 1 Names neuroserpin PI-12 peptidase inhibitor 12 serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1 serpin I1 serpin peptidase inhibitor clade I member 1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q26.1
Summary	This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008].
Disorder MIM:	602445
Disorder Html:	Encephalopathy, familial, with neuroserpin inclusion bodies, 604218 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_017006618.1	XP_016862107.1	neuroserpin isoform X1
NM_001122752.1	NP_001116224.1	neuroserpin precursor
XM_017006618.2	XP_016862107.1	neuroserpin isoform X1
NM_005025.4	NP_005016.1	neuroserpin precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SERPINI1	NP_001179167.1
Danio rerio (zebrafish)	serpini1	NP_001122164.1
	SERPINI1	XP_001094889.1
Drosophila melanogaster (fruit fly)	Spn55B	NP_524953.1
Xenopus tropicalis (tropical clawed frog)	serpini1	NP_001116965.1
Pan troglodytes (chimpanzee)	SERPINI1	XP_516861.2
Canis lupus familiaris (dog)	SERPINI1	XP_535853.3
Mus musculus (house mouse)	Serpini1	NP_033276.1
Rattus norvegicus (Norway rat)	Serpini1	NP_446231.1
Anopheles gambiae (African malaria mosquito)	SRPN10	XP_314159.2
Homo sapiens (human)	SERPINI1	NP_001116224.1
Gallus gallus (chicken)	SERPINI1	NP_001004411.1
Drosophila melanogaster (fruit fly)	Spn42Da	NP_724512.1

Gene Ontology
Bibliography

Related articles in PubMed

SERPINI1 pathogenic variants: An emerging cause of childhood-onset progressive myoclonic epilepsy.
Ranza E, Garcia-Tarodo S, Varvagiannis K, Guipponi M, Lobrinus JA, Bottani A, Kern I, Kurian M, Pittet MP, Antonarakis SE, Fluss J, Korff CM
American journal of medical genetics. Part A173(9)2456-2460(2017 Sep)

CCM3/SERPINI1 bidirectional promoter variants in patients with cerebral cavernous malformations: a molecular and functional study.
Scimone C, Bramanti P, Ruggeri A, Donato L, Alafaci C, Crisafulli C, Mucciardi M, Rinaldi C, Sidoti A, D'Angelo R
BMC medical genetics17(1)74(2016 Oct)

SERPINI1 regulates epithelial-mesenchymal transition in an orthotopic implantation model of colorectal cancer.
Matsuda Y, Miura K, Yamane J, Shima H, Fujibuchi W, Ishida K, Fujishima F, Ohnuma S, Sasaki H, Nagao M, Tanaka N, Satoh K, Naitoh T, Unno M
Cancer science107(5)619-28(2016 May)

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M
Cell164(4)805-17(2016 Feb)

Interactions between N-linked glycosylation and polymerisation of neuroserpin within the endoplasmic reticulum.
Moriconi C, Ordo?ez A, Lupo G, Gooptu B, Irving JA, Noto R, Martorana V, Manno M, Timpano V, Guadagno NA, Dalton L, Marciniak SJ, Lomas DA, Miranda E
The FEBS journal282(23)4565-79(2015 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We present two pediatric cases of progressive myoclonic epilepsy with SERPINI1 pathogenic variants that lead to a severe presentation.
Title: SERPINI1 pathogenic variants: An emerging cause of childhood-onset progressive myoclonic epilepsy.

Data indicated that rs9853967 and rs11714980 polymorphisms in CCM3 and SERPINI1respectively could be associated with a protective role in cerebral cavernous malformations disease.
Title: CCM3/SERPINI1 bidirectional promoter variants in patients with cerebral cavernous malformations: a molecular and functional study.

SERPINI1 is an important regulator of epithelial-mesenchymal transition in an orthotopic implantation model of colorectal cancer
Title: SERPINI1 regulates epithelial-mesenchymal transition in an orthotopic implantation model of colorectal cancer.

This C-terminal lability is not required for neuroserpin polymerisation in the endoplasmic reticulum, but the additional glycan facilitates degradation of the mutant protein during proteasomal impairment.
Title: Interactions between N-linked glycosylation and polymerisation of neuroserpin within the endoplasmic reticulum.

The thermal and chemical stability along with the polymerisation propensity of both Wild Type and Glu289Ala NS were characterized.
Title: The stability and activity of human neuroserpin are modulated by a salt bridge that stabilises the reactive centre loop.

The following SERPINI1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SERPINI1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19414	NM_001122752.1 Latest version!	Homo sapiens serpin family I member 1 (SERPINI1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$265.30 $379.00
OHu19414	NM_005025.4 Latest version!	Homo sapiens serpin family I member 1 (SERPINI1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$265.30 $379.00
OHu19414	XM_017006618.2 Latest version!	Homo sapiens serpin family I member 1 (SERPINI1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$265.30 $379.00
View Old Accession Versions >>
OHu19414	XM_017006618.1	Homo sapiens serpin family I member 1 (SERPINI1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SERPINI1 ( NM_001122752.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001116224.1 Homo sapiens serpin family I member 1 (SERPINI1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu19414
Clone ID Related Accession (Same CDS sequence)	XM_017006618.1 , NM_001122752.1 , XM_017006618.2 , NM_005025.4
Accession Version	NM_001122752.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1233bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-07
Organism	Homo sapiens(human)
Product	neuroserpin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA359846.1, BC018043.1, Z81326.1 and BQ086144.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.375357.1, SRR1660805.6102.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTTTCC TTGGACTCTT CTCTTTGCTG GTTCTGCAAA GTATGGCTAC AGGGGCCACT 
TTCCCTGAGG AAGCCATTGC TGACTTGTCA GTGAATATGT ATAATCGTCT TAGAGCCACT 
GGTGAAGATG AAAATATTCT CTTCTCTCCA TTGAGTATTG CTCTTGCAAT GGGAATGATG 
GAACTTGGGG CCCAAGGATC TACCCAGAAA GAAATCCGCC ACTCAATGGG ATATGACAGC 
CTAAAAAATG GTGAAGAATT TTCTTTCTTG AAGGAGTTTT CAAACATGGT AACTGCTAAA 
GAGAGCCAAT ATGTGATGAA AATTGCCAAT TCCTTGTTTG TGCAAAATGG ATTTCATGTC 
AATGAGGAGT TTTTGCAAAT GATGAAAAAA TATTTTAATG CAGCAGTAAA TCATGTGGAC 
TTCAGTCAAA ATGTAGCCGT GGCCAACTAC ATCAATAAGT GGGTGGAGAA TAACACAAAC 
AATCTGGTGA AAGATTTGGT ATCCCCAAGG GATTTTGATG CTGCCACTTA TCTGGCCCTC 
ATTAATGCTG TCTATTTCAA GGGGAACTGG AAGTCGCAGT TTAGGCCTGA AAATACTAGA 
ACCTTTTCTT TCACTAAAGA TGATGAAAGT GAAGTCCAAA TTCCAATGAT GTATCAGCAA 
GGAGAATTTT ATTATGGGGA ATTTAGTGAT GGCTCCAATG AAGCTGGTGG TATCTACCAA 
GTCCTAGAAA TACCATATGA AGGAGATGAA ATAAGCATGA TGCTGGTGCT GTCCAGACAG 
GAAGTTCCTC TTGCTACTCT GGAGCCATTA GTCAAAGCAC AGCTGGTTGA AGAATGGGCA 
AACTCTGTGA AGAAGCAAAA AGTAGAAGTA TACCTGCCCA GGTTCACAGT GGAACAGGAA 
ATTGATTTAA AAGATGTTTT GAAGGCTCTT GGAATAACTG AAATTTTCAT CAAAGATGCA 
AATTTGACAG GCCTCTCTGA TAATAAGGAG ATTTTTCTTT CCAAAGCAAT TCACAAGTCC 
TTCCTAGAGG TTAATGAAGA AGGCTCAGAA GCTGCTGCTG TCTCAGGAAT GATTGCAATT 
AGTAGGATGG CTGTGCTGTA TCCTCAAGTT ATTGTCGACC ATCCATTTTT CTTTCTTATC 
AGAAACAGGA GAACTGGTAC AATTCTATTC ATGGGACGAG TCATGCATCC TGAAACAATG 
AACACAAGTG GACATGATTT CGAAGAACTT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001116224.1
CDS	199..1431
Translation	MAFLGLFSLLVLQSMATGATFPEEAIADLSVNMYNRLRATGEDENILFSPLSIALAMGMMELGAQGSTQKEIRHSMGYDSLKNGEEFSFLKEFSNMVTAKESQYVMKIANSLFVQNGFHVNEEFLQMMKKYFNAAVNHVDFSQNVAVANYINKWVENNTNNLVKDLVSPRDFDAATYLALINAVYFKGNWKSQFRPENTRTFSFTKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLVLSRQEVPLATLEPLVKAQLVEEWANSVKKQKVEVYLPRFTVEQEIDLKDVLKALGITEIFIKDANLTGLSDNKEIFLSKAIHKSFLEVNEEGSEAAAVSGMIAISRMAVLYPQVIVDHPFFFLIRNRRTGTILFMGRVMHPETMNTSGHDFEEL

Target ORF information:

RefSeq Version	NM_001122752.1
Organism	Homo sapiens(human)
Definition	Homo sapiens serpin family I member 1 (SERPINI1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001122752.1

ORF Insert Sequence:

ATGGCTTTCC TTGGACTCTT CTCTTTGCTG GTTCTGCAAA GTATGGCTAC AGGGGCCACT 
TTCCCTGAGG AAGCCATTGC TGACTTGTCA GTGAATATGT ATAATCGTCT TAGAGCCACT 
GGTGAAGATG AAAATATTCT CTTCTCTCCA TTGAGTATTG CTCTTGCAAT GGGAATGATG 
GAACTTGGGG CCCAAGGATC TACCCAGAAA GAAATCCGCC ACTCAATGGG ATATGACAGC 
CTAAAAAATG GTGAAGAATT TTCTTTCTTG AAGGAGTTTT CAAACATGGT AACTGCTAAA 
GAGAGCCAAT ATGTGATGAA AATTGCCAAT TCCTTGTTTG TGCAAAATGG ATTTCATGTC 
AATGAGGAGT TTTTGCAAAT GATGAAAAAA TATTTTAATG CAGCAGTAAA TCATGTGGAC 
TTCAGTCAAA ATGTAGCCGT GGCCAACTAC ATCAATAAGT GGGTGGAGAA TAACACAAAC 
AATCTGGTGA AAGATTTGGT ATCCCCAAGG GATTTTGATG CTGCCACTTA TCTGGCCCTC 
ATTAATGCTG TCTATTTCAA GGGGAACTGG AAGTCGCAGT TTAGGCCTGA AAATACTAGA 
ACCTTTTCTT TCACTAAAGA TGATGAAAGT GAAGTCCAAA TTCCAATGAT GTATCAGCAA 
GGAGAATTTT ATTATGGGGA ATTTAGTGAT GGCTCCAATG AAGCTGGTGG TATCTACCAA 
GTCCTAGAAA TACCATATGA AGGAGATGAA ATAAGCATGA TGCTGGTGCT GTCCAGACAG 
GAAGTTCCTC TTGCTACTCT GGAGCCATTA GTCAAAGCAC AGCTGGTTGA AGAATGGGCA 
AACTCTGTGA AGAAGCAAAA AGTAGAAGTA TACCTGCCCA GGTTCACAGT GGAACAGGAA 
ATTGATTTAA AAGATGTTTT GAAGGCTCTT GGAATAACTG AAATTTTCAT CAAAGATGCA 
AATTTGACAG GCCTCTCTGA TAATAAGGAG ATTTTTCTTT CCAAAGCAAT TCACAAGTCC 
TTCCTAGAGG TTAATGAAGA AGGCTCAGAA GCTGCTGCTG TCTCAGGAAT GATTGCAATT 
AGTAGGATGG CTGTGCTGTA TCCTCAAGTT ATTGTCGACC ATCCATTTTT CTTTCTTATC 
AGAAACAGGA GAACTGGTAC AATTCTATTC ATGGGACGAG TCATGCATCC TGAAACAATG 
AACACAAGTG GACATGATTT CGAAGAACTT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SERPINI1 ( NM_005025.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005016.1 Homo sapiens serpin family I member 1 (SERPINI1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19414
Clone ID Related Accession (Same CDS sequence)	XM_017006618.1 , NM_001122752.1 , XM_017006618.2 , NM_005025.4
Accession Version	NM_005025.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1233bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Homo sapiens(human)
Product	neuroserpin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA270615.1, CR627434.1, AC079822.13 and BQ086144.1. This sequence is a reference standard in the RefSeqGene project. On Mar 19, 2008 this sequence version replaced NM_005025.3. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.242859.1, SRR1660809.150433.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTTTCC TTGGACTCTT CTCTTTGCTG GTTCTGCAAA GTATGGCTAC AGGGGCCACT 
TTCCCTGAGG AAGCCATTGC TGACTTGTCA GTGAATATGT ATAATCGTCT TAGAGCCACT 
GGTGAAGATG AAAATATTCT CTTCTCTCCA TTGAGTATTG CTCTTGCAAT GGGAATGATG 
GAACTTGGGG CCCAAGGATC TACCCAGAAA GAAATCCGCC ACTCAATGGG ATATGACAGC 
CTAAAAAATG GTGAAGAATT TTCTTTCTTG AAGGAGTTTT CAAACATGGT AACTGCTAAA 
GAGAGCCAAT ATGTGATGAA AATTGCCAAT TCCTTGTTTG TGCAAAATGG ATTTCATGTC 
AATGAGGAGT TTTTGCAAAT GATGAAAAAA TATTTTAATG CAGCAGTAAA TCATGTGGAC 
TTCAGTCAAA ATGTAGCCGT GGCCAACTAC ATCAATAAGT GGGTGGAGAA TAACACAAAC 
AATCTGGTGA AAGATTTGGT ATCCCCAAGG GATTTTGATG CTGCCACTTA TCTGGCCCTC 
ATTAATGCTG TCTATTTCAA GGGGAACTGG AAGTCGCAGT TTAGGCCTGA AAATACTAGA 
ACCTTTTCTT TCACTAAAGA TGATGAAAGT GAAGTCCAAA TTCCAATGAT GTATCAGCAA 
GGAGAATTTT ATTATGGGGA ATTTAGTGAT GGCTCCAATG AAGCTGGTGG TATCTACCAA 
GTCCTAGAAA TACCATATGA AGGAGATGAA ATAAGCATGA TGCTGGTGCT GTCCAGACAG 
GAAGTTCCTC TTGCTACTCT GGAGCCATTA GTCAAAGCAC AGCTGGTTGA AGAATGGGCA 
AACTCTGTGA AGAAGCAAAA AGTAGAAGTA TACCTGCCCA GGTTCACAGT GGAACAGGAA 
ATTGATTTAA AAGATGTTTT GAAGGCTCTT GGAATAACTG AAATTTTCAT CAAAGATGCA 
AATTTGACAG GCCTCTCTGA TAATAAGGAG ATTTTTCTTT CCAAAGCAAT TCACAAGTCC 
TTCCTAGAGG TTAATGAAGA AGGCTCAGAA GCTGCTGCTG TCTCAGGAAT GATTGCAATT 
AGTAGGATGG CTGTGCTGTA TCCTCAAGTT ATTGTCGACC ATCCATTTTT CTTTCTTATC 
AGAAACAGGA GAACTGGTAC AATTCTATTC ATGGGACGAG TCATGCATCC TGAAACAATG 
AACACAAGTG GACATGATTT CGAAGAACTT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005016.1
CDS	432..1664
Translation	MAFLGLFSLLVLQSMATGATFPEEAIADLSVNMYNRLRATGEDENILFSPLSIALAMGMMELGAQGSTQKEIRHSMGYDSLKNGEEFSFLKEFSNMVTAKESQYVMKIANSLFVQNGFHVNEEFLQMMKKYFNAAVNHVDFSQNVAVANYINKWVENNTNNLVKDLVSPRDFDAATYLALINAVYFKGNWKSQFRPENTRTFSFTKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLVLSRQEVPLATLEPLVKAQLVEEWANSVKKQKVEVYLPRFTVEQEIDLKDVLKALGITEIFIKDANLTGLSDNKEIFLSKAIHKSFLEVNEEGSEAAAVSGMIAISRMAVLYPQVIVDHPFFFLIRNRRTGTILFMGRVMHPETMNTSGHDFEEL

Target ORF information:

RefSeq Version	NM_005025.4
Organism	Homo sapiens(human)
Definition	Homo sapiens serpin family I member 1 (SERPINI1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005025.4

ORF Insert Sequence:

ATGGCTTTCC TTGGACTCTT CTCTTTGCTG GTTCTGCAAA GTATGGCTAC AGGGGCCACT 
TTCCCTGAGG AAGCCATTGC TGACTTGTCA GTGAATATGT ATAATCGTCT TAGAGCCACT 
GGTGAAGATG AAAATATTCT CTTCTCTCCA TTGAGTATTG CTCTTGCAAT GGGAATGATG 
GAACTTGGGG CCCAAGGATC TACCCAGAAA GAAATCCGCC ACTCAATGGG ATATGACAGC 
CTAAAAAATG GTGAAGAATT TTCTTTCTTG AAGGAGTTTT CAAACATGGT AACTGCTAAA 
GAGAGCCAAT ATGTGATGAA AATTGCCAAT TCCTTGTTTG TGCAAAATGG ATTTCATGTC 
AATGAGGAGT TTTTGCAAAT GATGAAAAAA TATTTTAATG CAGCAGTAAA TCATGTGGAC 
TTCAGTCAAA ATGTAGCCGT GGCCAACTAC ATCAATAAGT GGGTGGAGAA TAACACAAAC 
AATCTGGTGA AAGATTTGGT ATCCCCAAGG GATTTTGATG CTGCCACTTA TCTGGCCCTC 
ATTAATGCTG TCTATTTCAA GGGGAACTGG AAGTCGCAGT TTAGGCCTGA AAATACTAGA 
ACCTTTTCTT TCACTAAAGA TGATGAAAGT GAAGTCCAAA TTCCAATGAT GTATCAGCAA 
GGAGAATTTT ATTATGGGGA ATTTAGTGAT GGCTCCAATG AAGCTGGTGG TATCTACCAA 
GTCCTAGAAA TACCATATGA AGGAGATGAA ATAAGCATGA TGCTGGTGCT GTCCAGACAG 
GAAGTTCCTC TTGCTACTCT GGAGCCATTA GTCAAAGCAC AGCTGGTTGA AGAATGGGCA 
AACTCTGTGA AGAAGCAAAA AGTAGAAGTA TACCTGCCCA GGTTCACAGT GGAACAGGAA 
ATTGATTTAA AAGATGTTTT GAAGGCTCTT GGAATAACTG AAATTTTCAT CAAAGATGCA 
AATTTGACAG GCCTCTCTGA TAATAAGGAG ATTTTTCTTT CCAAAGCAAT TCACAAGTCC 
TTCCTAGAGG TTAATGAAGA AGGCTCAGAA GCTGCTGCTG TCTCAGGAAT GATTGCAATT 
AGTAGGATGG CTGTGCTGTA TCCTCAAGTT ATTGTCGACC ATCCATTTTT CTTTCTTATC 
AGAAACAGGA GAACTGGTAC AATTCTATTC ATGGGACGAG TCATGCATCC TGAAACAATG 
AACACAAGTG GACATGATTT CGAAGAACTT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SERPINI1 ( XM_017006618.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016862107.1 Homo sapiens serpin family I member 1 (SERPINI1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu19414
Clone ID Related Accession (Same CDS sequence)	XM_017006618.1 , NM_001122752.1 , XM_017006618.2 , NM_005025.4
Accession Version	XM_017006618.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1233bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	neuroserpin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTTTCC TTGGACTCTT CTCTTTGCTG GTTCTGCAAA GTATGGCTAC AGGGGCCACT 
TTCCCTGAGG AAGCCATTGC TGACTTGTCA GTGAATATGT ATAATCGTCT TAGAGCCACT 
GGTGAAGATG AAAATATTCT CTTCTCTCCA TTGAGTATTG CTCTTGCAAT GGGAATGATG 
GAACTTGGGG CCCAAGGATC TACCCAGAAA GAAATCCGCC ACTCAATGGG ATATGACAGC 
CTAAAAAATG GTGAAGAATT TTCTTTCTTG AAGGAGTTTT CAAACATGGT AACTGCTAAA 
GAGAGCCAAT ATGTGATGAA AATTGCCAAT TCCTTGTTTG TGCAAAATGG ATTTCATGTC 
AATGAGGAGT TTTTGCAAAT GATGAAAAAA TATTTTAATG CAGCAGTAAA TCATGTGGAC 
TTCAGTCAAA ATGTAGCCGT GGCCAACTAC ATCAATAAGT GGGTGGAGAA TAACACAAAC 
AATCTGGTGA AAGATTTGGT ATCCCCAAGG GATTTTGATG CTGCCACTTA TCTGGCCCTC 
ATTAATGCTG TCTATTTCAA GGGGAACTGG AAGTCGCAGT TTAGGCCTGA AAATACTAGA 
ACCTTTTCTT TCACTAAAGA TGATGAAAGT GAAGTCCAAA TTCCAATGAT GTATCAGCAA 
GGAGAATTTT ATTATGGGGA ATTTAGTGAT GGCTCCAATG AAGCTGGTGG TATCTACCAA 
GTCCTAGAAA TACCATATGA AGGAGATGAA ATAAGCATGA TGCTGGTGCT GTCCAGACAG 
GAAGTTCCTC TTGCTACTCT GGAGCCATTA GTCAAAGCAC AGCTGGTTGA AGAATGGGCA 
AACTCTGTGA AGAAGCAAAA AGTAGAAGTA TACCTGCCCA GGTTCACAGT GGAACAGGAA 
ATTGATTTAA AAGATGTTTT GAAGGCTCTT GGAATAACTG AAATTTTCAT CAAAGATGCA 
AATTTGACAG GCCTCTCTGA TAATAAGGAG ATTTTTCTTT CCAAAGCAAT TCACAAGTCC 
TTCCTAGAGG TTAATGAAGA AGGCTCAGAA GCTGCTGCTG TCTCAGGAAT GATTGCAATT 
AGTAGGATGG CTGTGCTGTA TCCTCAAGTT ATTGTCGACC ATCCATTTTT CTTTCTTATC 
AGAAACAGGA GAACTGGTAC AATTCTATTC ATGGGACGAG TCATGCATCC TGAAACAATG 
AACACAAGTG GACATGATTT CGAAGAACTT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016862107.1
CDS	497..1729
Translation	MAFLGLFSLLVLQSMATGATFPEEAIADLSVNMYNRLRATGEDENILFSPLSIALAMGMMELGAQGSTQKEIRHSMGYDSLKNGEEFSFLKEFSNMVTAKESQYVMKIANSLFVQNGFHVNEEFLQMMKKYFNAAVNHVDFSQNVAVANYINKWVENNTNNLVKDLVSPRDFDAATYLALINAVYFKGNWKSQFRPENTRTFSFTKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLVLSRQEVPLATLEPLVKAQLVEEWANSVKKQKVEVYLPRFTVEQEIDLKDVLKALGITEIFIKDANLTGLSDNKEIFLSKAIHKSFLEVNEEGSEAAAVSGMIAISRMAVLYPQVIVDHPFFFLIRNRRTGTILFMGRVMHPETMNTSGHDFEEL

Target ORF information:

RefSeq Version	XM_017006618.1
Organism	Homo sapiens(human)
Definition	Homo sapiens serpin family I member 1 (SERPINI1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017006618.1

ORF Insert Sequence:

ATGGCTTTCC TTGGACTCTT CTCTTTGCTG GTTCTGCAAA GTATGGCTAC AGGGGCCACT 
TTCCCTGAGG AAGCCATTGC TGACTTGTCA GTGAATATGT ATAATCGTCT TAGAGCCACT 
GGTGAAGATG AAAATATTCT CTTCTCTCCA TTGAGTATTG CTCTTGCAAT GGGAATGATG 
GAACTTGGGG CCCAAGGATC TACCCAGAAA GAAATCCGCC ACTCAATGGG ATATGACAGC 
CTAAAAAATG GTGAAGAATT TTCTTTCTTG AAGGAGTTTT CAAACATGGT AACTGCTAAA 
GAGAGCCAAT ATGTGATGAA AATTGCCAAT TCCTTGTTTG TGCAAAATGG ATTTCATGTC 
AATGAGGAGT TTTTGCAAAT GATGAAAAAA TATTTTAATG CAGCAGTAAA TCATGTGGAC 
TTCAGTCAAA ATGTAGCCGT GGCCAACTAC ATCAATAAGT GGGTGGAGAA TAACACAAAC 
AATCTGGTGA AAGATTTGGT ATCCCCAAGG GATTTTGATG CTGCCACTTA TCTGGCCCTC 
ATTAATGCTG TCTATTTCAA GGGGAACTGG AAGTCGCAGT TTAGGCCTGA AAATACTAGA 
ACCTTTTCTT TCACTAAAGA TGATGAAAGT GAAGTCCAAA TTCCAATGAT GTATCAGCAA 
GGAGAATTTT ATTATGGGGA ATTTAGTGAT GGCTCCAATG AAGCTGGTGG TATCTACCAA 
GTCCTAGAAA TACCATATGA AGGAGATGAA ATAAGCATGA TGCTGGTGCT GTCCAGACAG 
GAAGTTCCTC TTGCTACTCT GGAGCCATTA GTCAAAGCAC AGCTGGTTGA AGAATGGGCA 
AACTCTGTGA AGAAGCAAAA AGTAGAAGTA TACCTGCCCA GGTTCACAGT GGAACAGGAA 
ATTGATTTAA AAGATGTTTT GAAGGCTCTT GGAATAACTG AAATTTTCAT CAAAGATGCA 
AATTTGACAG GCCTCTCTGA TAATAAGGAG ATTTTTCTTT CCAAAGCAAT TCACAAGTCC 
TTCCTAGAGG TTAATGAAGA AGGCTCAGAA GCTGCTGCTG TCTCAGGAAT GATTGCAATT 
AGTAGGATGG CTGTGCTGTA TCCTCAAGTT ATTGTCGACC ATCCATTTTT CTTTCTTATC 
AGAAACAGGA GAACTGGTAC AATTCTATTC ATGGGACGAG TCATGCATCC TGAAACAATG 
AACACAAGTG GACATGATTT CGAAGAACTT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SERPINI1 ( XM_017006618.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016862107.1 Homo sapiens serpin family I member 1 (SERPINI1), transcript variant X1, mRNA.

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CloneID	OHu19414
Clone ID Related Accession (Same CDS sequence)	XM_017006618.1 , NM_001122752.1 , XM_017006618.2 , NM_005025.4
Accession Version	XM_017006618.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1233bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	neuroserpin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017006618.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTTTCC TTGGACTCTT CTCTTTGCTG GTTCTGCAAA GTATGGCTAC AGGGGCCACT 
TTCCCTGAGG AAGCCATTGC TGACTTGTCA GTGAATATGT ATAATCGTCT TAGAGCCACT 
GGTGAAGATG AAAATATTCT CTTCTCTCCA TTGAGTATTG CTCTTGCAAT GGGAATGATG 
GAACTTGGGG CCCAAGGATC TACCCAGAAA GAAATCCGCC ACTCAATGGG ATATGACAGC 
CTAAAAAATG GTGAAGAATT TTCTTTCTTG AAGGAGTTTT CAAACATGGT AACTGCTAAA 
GAGAGCCAAT ATGTGATGAA AATTGCCAAT TCCTTGTTTG TGCAAAATGG ATTTCATGTC 
AATGAGGAGT TTTTGCAAAT GATGAAAAAA TATTTTAATG CAGCAGTAAA TCATGTGGAC 
TTCAGTCAAA ATGTAGCCGT GGCCAACTAC ATCAATAAGT GGGTGGAGAA TAACACAAAC 
AATCTGGTGA AAGATTTGGT ATCCCCAAGG GATTTTGATG CTGCCACTTA TCTGGCCCTC 
ATTAATGCTG TCTATTTCAA GGGGAACTGG AAGTCGCAGT TTAGGCCTGA AAATACTAGA 
ACCTTTTCTT TCACTAAAGA TGATGAAAGT GAAGTCCAAA TTCCAATGAT GTATCAGCAA 
GGAGAATTTT ATTATGGGGA ATTTAGTGAT GGCTCCAATG AAGCTGGTGG TATCTACCAA 
GTCCTAGAAA TACCATATGA AGGAGATGAA ATAAGCATGA TGCTGGTGCT GTCCAGACAG 
GAAGTTCCTC TTGCTACTCT GGAGCCATTA GTCAAAGCAC AGCTGGTTGA AGAATGGGCA 
AACTCTGTGA AGAAGCAAAA AGTAGAAGTA TACCTGCCCA GGTTCACAGT GGAACAGGAA 
ATTGATTTAA AAGATGTTTT GAAGGCTCTT GGAATAACTG AAATTTTCAT CAAAGATGCA 
AATTTGACAG GCCTCTCTGA TAATAAGGAG ATTTTTCTTT CCAAAGCAAT TCACAAGTCC 
TTCCTAGAGG TTAATGAAGA AGGCTCAGAA GCTGCTGCTG TCTCAGGAAT GATTGCAATT 
AGTAGGATGG CTGTGCTGTA TCCTCAAGTT ATTGTCGACC ATCCATTTTT CTTTCTTATC 
AGAAACAGGA GAACTGGTAC AATTCTATTC ATGGGACGAG TCATGCATCC TGAAACAATG 
AACACAAGTG GACATGATTT CGAAGAACTT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016862107.1
CDS	109..1341
Translation	MAFLGLFSLLVLQSMATGATFPEEAIADLSVNMYNRLRATGEDENILFSPLSIALAMGMMELGAQGSTQKEIRHSMGYDSLKNGEEFSFLKEFSNMVTAKESQYVMKIANSLFVQNGFHVNEEFLQMMKKYFNAAVNHVDFSQNVAVANYINKWVENNTNNLVKDLVSPRDFDAATYLALINAVYFKGNWKSQFRPENTRTFSFTKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLVLSRQEVPLATLEPLVKAQLVEEWANSVKKQKVEVYLPRFTVEQEIDLKDVLKALGITEIFIKDANLTGLSDNKEIFLSKAIHKSFLEVNEEGSEAAAVSGMIAISRMAVLYPQVIVDHPFFFLIRNRRTGTILFMGRVMHPETMNTSGHDFEEL

Target ORF information:

RefSeq Version	XM_017006618.2
Organism	Homo sapiens(human)
Definition	Homo sapiens serpin family I member 1 (SERPINI1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017006618.2

ORF Insert Sequence:

ATGGCTTTCC TTGGACTCTT CTCTTTGCTG GTTCTGCAAA GTATGGCTAC AGGGGCCACT 
TTCCCTGAGG AAGCCATTGC TGACTTGTCA GTGAATATGT ATAATCGTCT TAGAGCCACT 
GGTGAAGATG AAAATATTCT CTTCTCTCCA TTGAGTATTG CTCTTGCAAT GGGAATGATG 
GAACTTGGGG CCCAAGGATC TACCCAGAAA GAAATCCGCC ACTCAATGGG ATATGACAGC 
CTAAAAAATG GTGAAGAATT TTCTTTCTTG AAGGAGTTTT CAAACATGGT AACTGCTAAA 
GAGAGCCAAT ATGTGATGAA AATTGCCAAT TCCTTGTTTG TGCAAAATGG ATTTCATGTC 
AATGAGGAGT TTTTGCAAAT GATGAAAAAA TATTTTAATG CAGCAGTAAA TCATGTGGAC 
TTCAGTCAAA ATGTAGCCGT GGCCAACTAC ATCAATAAGT GGGTGGAGAA TAACACAAAC 
AATCTGGTGA AAGATTTGGT ATCCCCAAGG GATTTTGATG CTGCCACTTA TCTGGCCCTC 
ATTAATGCTG TCTATTTCAA GGGGAACTGG AAGTCGCAGT TTAGGCCTGA AAATACTAGA 
ACCTTTTCTT TCACTAAAGA TGATGAAAGT GAAGTCCAAA TTCCAATGAT GTATCAGCAA 
GGAGAATTTT ATTATGGGGA ATTTAGTGAT GGCTCCAATG AAGCTGGTGG TATCTACCAA 
GTCCTAGAAA TACCATATGA AGGAGATGAA ATAAGCATGA TGCTGGTGCT GTCCAGACAG 
GAAGTTCCTC TTGCTACTCT GGAGCCATTA GTCAAAGCAC AGCTGGTTGA AGAATGGGCA 
AACTCTGTGA AGAAGCAAAA AGTAGAAGTA TACCTGCCCA GGTTCACAGT GGAACAGGAA 
ATTGATTTAA AAGATGTTTT GAAGGCTCTT GGAATAACTG AAATTTTCAT CAAAGATGCA 
AATTTGACAG GCCTCTCTGA TAATAAGGAG ATTTTTCTTT CCAAAGCAAT TCACAAGTCC 
TTCCTAGAGG TTAATGAAGA AGGCTCAGAA GCTGCTGCTG TCTCAGGAAT GATTGCAATT 
AGTAGGATGG CTGTGCTGTA TCCTCAAGTT ATTGTCGACC ATCCATTTTT CTTTCTTATC 
AGAAACAGGA GAACTGGTAC AATTCTATTC ATGGGACGAG TCATGCATCC TGAAACAATG 
AACACAAGTG GACATGATTT CGAAGAACTT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

SERPINI1 pathogenic variants: An emerging cause of childhood-onset progressive myoclonic epilepsy.
American journal of medical genetics. Part A173(9)2456-2460(2017 Sep)
Ranza E,Garcia-Tarodo S,Varvagiannis K,Guipponi M,Lobrinus JA,Bottani A,Kern I,Kurian M,Pittet MP,Antonarakis SE,Fluss J,Korff CM

CCM3/SERPINI1 bidirectional promoter variants in patients with cerebral cavernous malformations: a molecular and functional study.
BMC medical genetics17(1)74(2016 Oct)
Scimone C,Bramanti P,Ruggeri A,Donato L,Alafaci C,Crisafulli C,Mucciardi M,Rinaldi C,Sidoti A,D'Angelo R

SERPINI1 regulates epithelial-mesenchymal transition in an orthotopic implantation model of colorectal cancer.
Cancer science107(5)619-28(2016 May)
Matsuda Y,Miura K,Yamane J,Shima H,Fujibuchi W,Ishida K,Fujishima F,Ohnuma S,Sasaki H,Nagao M,Tanaka N,Satoh K,Naitoh T,Unno M

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Cell164(4)805-17(2016 Feb)
Yang X,Coulombe-Huntington J,Kang S,Sheynkman GM,Hao T,Richardson A,Sun S,Yang F,Shen YA,Murray RR,Spirohn K,Begg BE,Duran-Frigola M,MacWilliams A,Pevzner SJ,Zhong Q,Trigg SA,Tam S,Ghamsari L,Sahni N,Yi S,Rodriguez MD,Balcha D,Tan G,Costanzo M,Andrews B,Boone C,Zhou XJ,Salehi-Ashtiani K,Charloteaux B,Chen AA,Calderwood MA,Aloy P,Roth FP,Hill DE,Iakoucheva LM,Xia Y,Vidal M

Interactions between N-linked glycosylation and polymerisation of neuroserpin within the endoplasmic reticulum.
The FEBS journal282(23)4565-79(2015 Dec)
Moriconi C,Ordo?ez A,Lupo G,Gooptu B,Irving JA,Noto R,Martorana V,Manno M,Timpano V,Guadagno NA,Dalton L,Marciniak SJ,Lomas DA,Miranda E

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SERPINI1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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