ATP6V0C cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ATP6V0C
Entrez Gene ID	527
Full Name	ATPase H+ transporting V0 subunit c
Synonyms	ATP6C,ATP6L,ATPL,VATL,VPPC,Vma3
General protein information	Preferred Names ATPase H+ transporting V0 subunit c Names V-type proton ATPase 16 kDa proteolipid subunit ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c H(+)-transporting two-sector ATPase, 16 kDa subunit V-ATPase 16 kDa proteolipid subunit vacuolar ATP synthase 16 kDa proteolipid subunit vacuolar H+ ATPase proton channel subunit vacuolar proton pump 16 kDa proteolipid subunit
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p13.3
Summary	This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17. [provided by RefSeq, Nov 2010].
Disorder MIM:	108745

mRNA and Protein(s)

mRNA	Protein	Name
NM_001694.3	NP_001685.1	V-type proton ATPase 16 kDa proteolipid subunit
NM_001198569.1	NP_001185498.1	V-type proton ATPase 16 kDa proteolipid subunit
NM_001694.4	NP_001685.1	V-type proton ATPase 16 kDa proteolipid subunit

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	atp6v0cb	NP_991117.1
Bos taurus (cattle)	ATP6V0C	NP_001017954.1
Rattus norvegicus (Norway rat)	Atp6v0c	NP_570836.1
Danio rerio (zebrafish)	atp6v0ca	NP_001098606.2
Drosophila melanogaster (fruit fly)	Vha16-3	NP_001189086.1
Saccharomyces cerevisiae (baker's yeast)	VMA3	NP_010887.3
Eremothecium gossypii	AGOS_AEL074W	NP_984787.1
Neurospora crassa	NCU01332	XP_961418.2
Homo sapiens (human)	ATP6V0C	NP_001185498.1
Canis lupus familiaris (dog)	ATP6V0C	XP_537002.1
Gallus gallus (chicken)	ATP6V0C	NP_001264953.1
Caenorhabditis elegans (roundworm)	vha-2	NP_499166.1
Schizosaccharomyces pombe (fission yeast)	vma3	NP_594799.1
Pan troglodytes (chimpanzee)	ATP6V0C	XP_510748.3
Drosophila melanogaster (fruit fly)	Vha16-1	NP_724476.1
Caenorhabditis elegans (roundworm)	vha-1	NP_499165.1
Magnaporthe oryzae (rice blast fungus)	MGG_02466	XP_003709260.1
Oryza sativa (rice)	Os01g0962300	NP_001045477.1
	ATP6V0C	XP_001088617.1
Mus musculus (house mouse)	Atp6v0c	NP_033859.1
Caenorhabditis elegans (roundworm)	vha-3	NP_500188.1
Kluyveromyces lactis	KLLA0E22441g	XP_454966.1
Xenopus tropicalis (tropical clawed frog)	atp6v0c	NP_988893.1

Gene Ontology
Bibliography

Related articles in PubMed

Silencing of vacuolar ATPase c?subunit ATP6V0C inhibits the invasion of prostate cancer cells through a LASS2/TMSG1-independent manner.
Zou P, Yang Y, Xu X, Liu B, Mei F, You J, Liu Q, Pei F
Oncology reports39(1)298-306(2018 Jan)

Retinoblastoma-binding protein 2 induces epithelial-mesenchymal transition in esophageal squamous cancer cells.
Qiao N, Wang S, Hu L
Biotechnology letters37(12)2365-70(2015 Dec)

AGPAT9 suppresses cell growth, invasion and metastasis by counteracting acidic tumor microenvironment through KLF4/LASS2/V-ATPase signaling pathway in breast cancer.
Fan SH, Wang YY, Wu ZY, Zhang ZF, Lu J, Li MQ, Shan Q, Wu DM, Sun CH, Hu B, Zheng YL
Oncotarget6(21)18406-17(2015 Jul)

GABRA1 and STXBP1: novel genetic causes of Dravet syndrome.
Carvill GL, Weckhuysen S, McMahon JM, Hartmann C, M?ller RS, Hjalgrim H, Cook J, Geraghty E, O'Roak BJ, Petrou S, Clarke A, Gill D, Sadleir LG, Muhle H, von Spiczak S, Nikanorova M, Hodgson BL, Gazina EV, Suls A, Shendure J, Dibbens LM, De Jonghe P, Helbig I, Berkovic SF, Scheffer IE, Mefford HC
Neurology82(14)1245-53(2014 Apr)

ATP6V0C knockdown in neuroblastoma cells alters autophagy-lysosome pathway function and metabolism of proteins that accumulate in neurodegenerative disease.
Mangieri LR, Mader BJ, Thomas CE, Taylor CA, Luker AM, Tse TE, Huisingh C, Shacka JJ
PloS one9(4)e93257(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that 1-acylglycerol-3-phosphate O-acyltransferase 9 (AGPAT9) inhibit cell growth by regulating expression of KLF4/LASS2/V-ATPase proteins in breast cancer.
Title: AGPAT9 suppresses cell growth, invasion and metastasis by counteracting acidic tumor microenvironment through KLF4/LASS2/V-ATPase signaling pathway in breast cancer.

The consequences of pharmacological inhibition of v-ATPase (by concanamycin) on proliferation, migration, VEGF-receptor 2 (VEGFR2) trafficking and signaling, as well as Notch-mediated transcription in endothelial cells, were examined.
Title: Regulation of endothelial signaling and migration by v-ATPase.

Results show that inhibition of V-ATPase by archazolid reduces the activity of prometastatic proteases like cathepsin B in vitro and in vivo.
Title: V-ATPase inhibition by archazolid leads to lysosomal dysfunction resulting in impaired cathepsin B activation in vivo.

A role for ATP6V0C in maintaining constitutive and stress-induced ALP function.
Title: ATP6V0C knockdown in neuroblastoma cells alters autophagy-lysosome pathway function and metabolism of proteins that accumulate in neurodegenerative disease.

siRNA knockdown of ATP6V0C resulted in almost complete loss of infectious virus production, suggesting that an human cytomegalovirus microRNA targets a crucial cellular factor required for virus replication.
Title: Systematic microRNA analysis identifies ATP6V0C as an essential host factor for human cytomegalovirus replication.

The following ATP6V0C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ATP6V0C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27533	NM_001694.4 Latest version!	Homo sapiens ATPase H+ transporting V0 subunit c (ATP6V0C), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu27533	NM_001198569.1 Latest version!	Homo sapiens ATPase H+ transporting V0 subunit c (ATP6V0C), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu27533	NM_001694.3	Homo sapiens ATPase H+ transporting V0 subunit c (ATP6V0C), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ATP6V0C ( NM_001694.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001685.1 Homo sapiens ATPase H+ transporting V0 subunit c (ATP6V0C), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu27533
Clone ID Related Accession (Same CDS sequence)	NM_001694.3 , NM_001198569.1 , NM_001694.4
Accession Version	NM_001694.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 468bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	V-type proton ATPase 16 kDa proteolipid subunit
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC093525.3 and BC009290.2. On Nov 2, 2010 this sequence version replaced NM_001694.2. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M62762.1, SRR1163658.378225.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCGAGT CCAAGAGCGG CCCCGAGTAT GCTTCGTTTT TCGCCGTCAT GGGCGCCTCG 
GCCGCCATGG TCTTCAGCGC CCTGGGCGCT GCCTATGGCA CAGCCAAGAG CGGTACCGGC 
ATTGCGGCCA TGTCTGTCAT GCGGCCGGAG CAGATCATGA AGTCCATCAT CCCAGTGGTC 
ATGGCTGGCA TCATCGCCAT CTACGGCCTG GTGGTGGCAG TCCTCATCGC CAACTCCCTG 
AATGACGACA TCAGCCTCTA CAAGAGCTTC CTCCAGCTGG GCGCCGGCCT GAGCGTGGGC 
CTGAGCGGCC TGGCAGCCGG CTTTGCCATC GGCATCGTGG GGGACGCTGG CGTGCGGGGC 
ACCGCCCAGC AGCCCCGACT ATTCGTGGGC ATGATCCTGA TTCTCATCTT CGCCGAGGTG 
CTCGGCCTCT ACGGTCTCAT CGTCGCCCTC ATCCTCTCCA CAAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001685.1
CDS	235..702
Translation	MSESKSGPEYASFFAVMGASAAMVFSALGAAYGTAKSGTGIAAMSVMRPEQIMKSIIPVVMAGIIAIYGLVVAVLIANSLNDDISLYKSFLQLGAGLSVGLSGLAAGFAIGIVGDAGVRGTAQQPRLFVGMILILIFAEVLGLYGLIVALILSTK

Target ORF information:

RefSeq Version	NM_001694.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ATPase H+ transporting V0 subunit c (ATP6V0C), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001694.3

ORF Insert Sequence:

ATGTCCGAGT CCAAGAGCGG CCCCGAGTAT GCTTCGTTTT TCGCCGTCAT GGGCGCCTCG 
GCCGCCATGG TCTTCAGCGC CCTGGGCGCT GCCTATGGCA CAGCCAAGAG CGGTACCGGC 
ATTGCGGCCA TGTCTGTCAT GCGGCCGGAG CAGATCATGA AGTCCATCAT CCCAGTGGTC 
ATGGCTGGCA TCATCGCCAT CTACGGCCTG GTGGTGGCAG TCCTCATCGC CAACTCCCTG 
AATGACGACA TCAGCCTCTA CAAGAGCTTC CTCCAGCTGG GCGCCGGCCT GAGCGTGGGC 
CTGAGCGGCC TGGCAGCCGG CTTTGCCATC GGCATCGTGG GGGACGCTGG CGTGCGGGGC 
ACCGCCCAGC AGCCCCGACT ATTCGTGGGC ATGATCCTGA TTCTCATCTT CGCCGAGGTG 
CTCGGCCTCT ACGGTCTCAT CGTCGCCCTC ATCCTCTCCA CAAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATP6V0C ( NM_001198569.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001185498.1 Homo sapiens ATPase H+ transporting V0 subunit c (ATP6V0C), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu27533
Clone ID Related Accession (Same CDS sequence)	NM_001694.3 , NM_001198569.1 , NM_001694.4
Accession Version	NM_001198569.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 468bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Homo sapiens(human)
Product	V-type proton ATPase 16 kDa proteolipid subunit
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AW161158.1, AC093525.3 and BC009290.2. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AW161158.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCGAGT CCAAGAGCGG CCCCGAGTAT GCTTCGTTTT TCGCCGTCAT GGGCGCCTCG 
GCCGCCATGG TCTTCAGCGC CCTGGGCGCT GCCTATGGCA CAGCCAAGAG CGGTACCGGC 
ATTGCGGCCA TGTCTGTCAT GCGGCCGGAG CAGATCATGA AGTCCATCAT CCCAGTGGTC 
ATGGCTGGCA TCATCGCCAT CTACGGCCTG GTGGTGGCAG TCCTCATCGC CAACTCCCTG 
AATGACGACA TCAGCCTCTA CAAGAGCTTC CTCCAGCTGG GCGCCGGCCT GAGCGTGGGC 
CTGAGCGGCC TGGCAGCCGG CTTTGCCATC GGCATCGTGG GGGACGCTGG CGTGCGGGGC 
ACCGCCCAGC AGCCCCGACT ATTCGTGGGC ATGATCCTGA TTCTCATCTT CGCCGAGGTG 
CTCGGCCTCT ACGGTCTCAT CGTCGCCCTC ATCCTCTCCA CAAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001185498.1
CDS	76..543
Translation	MSESKSGPEYASFFAVMGASAAMVFSALGAAYGTAKSGTGIAAMSVMRPEQIMKSIIPVVMAGIIAIYGLVVAVLIANSLNDDISLYKSFLQLGAGLSVGLSGLAAGFAIGIVGDAGVRGTAQQPRLFVGMILILIFAEVLGLYGLIVALILSTK

Target ORF information:

RefSeq Version	NM_001198569.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ATPase H+ transporting V0 subunit c (ATP6V0C), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001198569.1

ORF Insert Sequence:

ATGTCCGAGT CCAAGAGCGG CCCCGAGTAT GCTTCGTTTT TCGCCGTCAT GGGCGCCTCG 
GCCGCCATGG TCTTCAGCGC CCTGGGCGCT GCCTATGGCA CAGCCAAGAG CGGTACCGGC 
ATTGCGGCCA TGTCTGTCAT GCGGCCGGAG CAGATCATGA AGTCCATCAT CCCAGTGGTC 
ATGGCTGGCA TCATCGCCAT CTACGGCCTG GTGGTGGCAG TCCTCATCGC CAACTCCCTG 
AATGACGACA TCAGCCTCTA CAAGAGCTTC CTCCAGCTGG GCGCCGGCCT GAGCGTGGGC 
CTGAGCGGCC TGGCAGCCGG CTTTGCCATC GGCATCGTGG GGGACGCTGG CGTGCGGGGC 
ACCGCCCAGC AGCCCCGACT ATTCGTGGGC ATGATCCTGA TTCTCATCTT CGCCGAGGTG 
CTCGGCCTCT ACGGTCTCAT CGTCGCCCTC ATCCTCTCCA CAAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATP6V0C ( NM_001694.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001685.1 Homo sapiens ATPase H+ transporting V0 subunit c (ATP6V0C), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu27533
Clone ID Related Accession (Same CDS sequence)	NM_001694.3 , NM_001198569.1 , NM_001694.4
Accession Version	NM_001694.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 468bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	V-type proton ATPase 16 kDa proteolipid subunit
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC093525.3 and BC009290.2. On Nov 22, 2018 this sequence version replaced NM_001694.3. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.668852.1, SRR3476690.254198.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000330398.9/ ENSP00000329757.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCCGAGT CCAAGAGCGG CCCCGAGTAT GCTTCGTTTT TCGCCGTCAT GGGCGCCTCG 
GCCGCCATGG TCTTCAGCGC CCTGGGCGCT GCCTATGGCA CAGCCAAGAG CGGTACCGGC 
ATTGCGGCCA TGTCTGTCAT GCGGCCGGAG CAGATCATGA AGTCCATCAT CCCAGTGGTC 
ATGGCTGGCA TCATCGCCAT CTACGGCCTG GTGGTGGCAG TCCTCATCGC CAACTCCCTG 
AATGACGACA TCAGCCTCTA CAAGAGCTTC CTCCAGCTGG GCGCCGGCCT GAGCGTGGGC 
CTGAGCGGCC TGGCAGCCGG CTTTGCCATC GGCATCGTGG GGGACGCTGG CGTGCGGGGC 
ACCGCCCAGC AGCCCCGACT ATTCGTGGGC ATGATCCTGA TTCTCATCTT CGCCGAGGTG 
CTCGGCCTCT ACGGTCTCAT CGTCGCCCTC ATCCTCTCCA CAAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001685.1
CDS	153..620
Translation	MSESKSGPEYASFFAVMGASAAMVFSALGAAYGTAKSGTGIAAMSVMRPEQIMKSIIPVVMAGIIAIYGLVVAVLIANSLNDDISLYKSFLQLGAGLSVGLSGLAAGFAIGIVGDAGVRGTAQQPRLFVGMILILIFAEVLGLYGLIVALILSTK

Target ORF information:

RefSeq Version	NM_001694.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ATPase H+ transporting V0 subunit c (ATP6V0C), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001694.4

ORF Insert Sequence:

ATGTCCGAGT CCAAGAGCGG CCCCGAGTAT GCTTCGTTTT TCGCCGTCAT GGGCGCCTCG 
GCCGCCATGG TCTTCAGCGC CCTGGGCGCT GCCTATGGCA CAGCCAAGAG CGGTACCGGC 
ATTGCGGCCA TGTCTGTCAT GCGGCCGGAG CAGATCATGA AGTCCATCAT CCCAGTGGTC 
ATGGCTGGCA TCATCGCCAT CTACGGCCTG GTGGTGGCAG TCCTCATCGC CAACTCCCTG 
AATGACGACA TCAGCCTCTA CAAGAGCTTC CTCCAGCTGG GCGCCGGCCT GAGCGTGGGC 
CTGAGCGGCC TGGCAGCCGG CTTTGCCATC GGCATCGTGG GGGACGCTGG CGTGCGGGGC 
ACCGCCCAGC AGCCCCGACT ATTCGTGGGC ATGATCCTGA TTCTCATCTT CGCCGAGGTG 
CTCGGCCTCT ACGGTCTCAT CGTCGCCCTC ATCCTCTCCA CAAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Silencing of vacuolar ATPase c?subunit ATP6V0C inhibits the invasion of prostate cancer cells through a LASS2/TMSG1-independent manner.
Oncology reports39(1)298-306(2018 Jan)
Zou P,Yang Y,Xu X,Liu B,Mei F,You J,Liu Q,Pei F

Retinoblastoma-binding protein 2 induces epithelial-mesenchymal transition in esophageal squamous cancer cells.
Biotechnology letters37(12)2365-70(2015 Dec)
Qiao N,Wang S,Hu L

AGPAT9 suppresses cell growth, invasion and metastasis by counteracting acidic tumor microenvironment through KLF4/LASS2/V-ATPase signaling pathway in breast cancer.
Oncotarget6(21)18406-17(2015 Jul)
Fan SH,Wang YY,Wu ZY,Zhang ZF,Lu J,Li MQ,Shan Q,Wu DM,Sun CH,Hu B,Zheng YL

GABRA1 and STXBP1: novel genetic causes of Dravet syndrome.
Neurology82(14)1245-53(2014 Apr)
Carvill GL,Weckhuysen S,McMahon JM,Hartmann C,M?ller RS,Hjalgrim H,Cook J,Geraghty E,O'Roak BJ,Petrou S,Clarke A,Gill D,Sadleir LG,Muhle H,von Spiczak S,Nikanorova M,Hodgson BL,Gazina EV,Suls A,Shendure J,Dibbens LM,De Jonghe P,Helbig I,Berkovic SF,Scheffer IE,Mefford HC

ATP6V0C knockdown in neuroblastoma cells alters autophagy-lysosome pathway function and metabolism of proteins that accumulate in neurodegenerative disease.
PloS one9(4)e93257(2014)
Mangieri LR,Mader BJ,Thomas CE,Taylor CA,Luker AM,Tse TE,Huisingh C,Shacka JJ

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ATP6V0C cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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