ATP6V1B2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ATP6V1B2
Entrez Gene ID	526
Full Name	ATPase H+ transporting V1 subunit B2
Synonyms	ATP6B1B2,ATP6B2,DOOD,HO57,VATB,VPP3,Vma2,ZLS2
General protein information	Preferred Names ATPase H+ transporting V1 subunit B2 Names V-type proton ATPase subunit B, brain isoform ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 H+ transporting two-sector ATPase V-ATPase B2 subunit V-ATPase subunit B 2 endomembrane proton pump 58 kDa subunit testicular secretory protein Li 65 vacuolar H+-ATPase 56,000 subunit vacuolar proton pump subunit B 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8p21.3
Summary	This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts. [provided by RefSeq, Jul 2008].
Disorder MIM:	606939
Disorder Html:	Zimmermann-Laband syndrome 2, 616455 (3); Deafness, congenital, with onychodystrophy, autosomal dominant, 124480 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001693.4	NP_001684.2	V-type proton ATPase subunit B, brain isoform
NM_001693.3	NP_001684.2	V-type proton ATPase subunit B, brain isoform

Pathways from BioSystems

Homologies

Homo sapiens (human)	ATP6V1B2	NP_001684.2
Pan troglodytes (chimpanzee)	ATP6V1B2	XP_519638.2
Saccharomyces cerevisiae (baker's yeast)	VMA2	NP_009685.3
Arabidopsis thaliana (thale cress)	AT1G20260	NP_173451.5
Oryza sativa (rice)	Os06g0568200	NP_001057902.1
Rattus norvegicus (Norway rat)	Atp6v1b2	NP_476561.1
Caenorhabditis elegans (roundworm)	spe-5	NP_491518.1
Magnaporthe oryzae (rice blast fungus)	MGG_03244	XP_003716730.1
Xenopus tropicalis (tropical clawed frog)	atp6v1b2	NP_001072182.1
	ATP6V1B2	XP_001100869.1
Canis lupus familiaris (dog)	ATP6V1B2	XP_543263.2
Bos taurus (cattle)	ATP6V1B2	NP_788844.2
Mus musculus (house mouse)	Atp6v1b2	NP_031535.2
Arabidopsis thaliana (thale cress)	AT1G76030	NP_177729.1
Gallus gallus (chicken)	ATP6V1B2	XP_424534.3
Drosophila melanogaster (fruit fly)	Vha55	NP_001163597.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002884	XP_312029.3
Schizosaccharomyces pombe (fission yeast)	vma2	NP_594623.1
Neurospora crassa	NCU08515	XP_963165.1
Danio rerio (zebrafish)	atp6v1b2	NP_878299.1
Kluyveromyces lactis	KLLA0D09152g	XP_453470.1
Eremothecium gossypii	AGOS_ADL380W	NP_983716.1

Gene Ontology
Bibliography

Related articles in PubMed

Changes in V-ATPase subunits of human urinary exosomes reflect the renal response to acute acid/alkali loading and the defects in distal renal tubular?acidosis.
Pathare G, Dhayat NA, Mohebbi N, Wagner CA, Bobulescu IA, Moe OW, Fuster DG
Kidney international(2018 Jan)

Association of ATP6V1B2 rs1106634 with lifetime risk of depression and hippocampal neurocognitive deficits: possible novel mechanisms in the etiopathology of depression.
Gonda X, Eszlari N, Anderson IM, Deakin JF, Bagdy G, Juhasz G
Translational psychiatry6(11)e945(2016 11)

Mutations in KCNH1 and ATP6V1B2 cause Zimmermann-Laband syndrome.
Kort?m F, Caputo V, Bauer CK, Stella L, Ciolfi A, Alawi M, Bocchinfuso G, Flex E, Paolacci S, Dentici ML, Grammatico P, Korenke GC, Leuzzi V, Mowat D, Nair LD, Nguyen TT, Thierry P, White SM, Dallapiccola B, Pizzuti A, Campeau PM, Tartaglia M, Kutsche K
Nature genetics47(6)661-7(2015 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We conclude that the effects of variation in the vacuolar ATPase may point to a new molecular mechanism that influences the long-term development of depression. This mechanism may involve dysfunction specifically in hippocampal circuitry and cognitive impairment that characterizes recurrent and chronic depression.
Title: Association of ATP6V1B2 rs1106634 with lifetime risk of depression and hippocampal neurocognitive deficits: possible novel mechanisms in the etiopathology of depression.

A missense mutation in ATP6V1B2 associated with Zimmermann-Laband syndrome.
Title: Mutations in KCNH1 and ATP6V1B2 cause Zimmermann-Laband syndrome.

ATP6V1B2 is somatically mutated in 22% of follicular lymphoma tumors. Mutation hotspots found at Y371 and R400.
Title: Mutations in early follicular lymphoma progenitors are associated with suppressed antigen presentation.

The ATP6V1B2 p.Arg506X is a haploinsufficient mutation and resulted in abnormal acidification in lysosomes.
Title: De novo mutation in ATP6V1B2 impairs lysosome acidification and causes dominant deafness-onychodystrophy syndrome.

This protein has been found differentially expressed in the anterior cingulate cortex from patients with schizophrenia
Title: Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia.

The following ATP6V1B2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ATP6V1B2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02138	NM_001693.4 Latest version!	Homo sapiens ATPase H+ transporting V1 subunit B2 (ATP6V1B2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu02138	NM_001693.3	Homo sapiens ATPase H+ transporting V1 subunit B2 (ATP6V1B2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ATP6V1B2 ( NM_001693.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001684.2 Homo sapiens ATPase H+ transporting V1 subunit B2 (ATP6V1B2), mRNA.

Price & Availability↑

CloneID	OHu02138
Clone ID Related Accession (Same CDS sequence)	NM_001693.4 , NM_001693.3
Accession Version	NM_001693.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1536bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Homo sapiens(human)
Product	V-type proton ATPase subunit B, brain isoform
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC025853.17, BC030640.2, X62949.1 and BC007309.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_001693.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.37208.1, SRR3476690.686943.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000276390.7/ ENSP00000276390.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGCTGC GGGCGATGCG GGGGATTGTC AACGGGGCCG CACCCGAGCT ACCCGTGCCC 
ACCGGTGGGC CGGCGGTGGG AGCTCGGGAG CAGGCGCTGG CAGTCAGTCG GAACTACCTC 
TCCCAGCCTC GCCTCACATA CAAGACAGTA TCTGGAGTCA ATGGTCCACT AGTGATCTTA 
GATCATGTTA AGTTTCCCAG GTATGCTGAA ATTGTCCATT TGACCTTACC GGATGGCACA 
AAGAGAAGTG GGCAAGTTCT GGAAGTTAGT GGTTCCAAGG CAGTAGTTCA GGTATTTGAA 
GGGACTTCAG GTATAGATGC TAAGAAAACG TCCTGTGAGT TTACTGGGGA TATTCTCCGA 
ACACCGGTGT CTGAGGATAT GCTTGGTCGG GTATTCAATG GATCGGGAAA ACCCATTGAC 
AGAGGTCCTG TTGTACTGGC CGAAGACTTC CTTGATATCA TGGGTCAGCC AATCAACCCT 
CAATGTCGAA TCTACCCAGA GGAAATGATT CAGACTGGCA TTTCGGCCAT CGATGGGATG 
AACAGTATTG CTAGGGGGCA GAAAATTCCT ATCTTCTCTG CTGCTGGGCT ACCACACAAT 
GAGATTGCAG CTCAGATCTG TCGCCAGGCT GGTTTGGTAA AGAAATCCAA AGATGTAGTA 
GACTACAGTG AGGAAAATTT TGCAATTGTA TTTGCTGCTA TGGGTGTAAA CATGGAAACT 
GCCCGGTTCT TCAAATCTGA CTTTGAAGAA AATGGCTCAA TGGACAATGT CTGCCTCTTT 
TTGAACTTGG CTAATGACCC AACCATTGAG CGAATTATCA CTCCTCGCCT GGCTCTAACC 
ACAGCTGAAT TTCTGGCGTA CCAATGTGAG AAACATGTAT TGGTTATTCT AACAGACATG 
AGTTCTTATG CTGAAGCACT TCGAGAGGTT TCAGCAGCCA GGGAAGAGGT ACCTGGTCGA 
CGAGGTTTTC CAGGTTACAT GTATACAGAT TTAGCCACGA TATATGAACG CGCTGGGCGA 
GTGGAAGGGA GAAACGGCTC GATTACTCAA ATCCCTATTC TAACCATGCC TAATGATGAT 
ATCACTCACC CCATCCCAGA CTTGACTGGC TACATTACAG AGGGGCAGAT CTATGTGGAC 
AGACAGCTGC ACAACAGACA GATTTATCCA CCTATCAATG TGCTGCCCTC ACTATCACGG 
TTAATGAAGT CTGCTATTGG AGAAGGGATG ACCAGGAAGG ATCATGCCGA TGTATCTAAC 
CAGCTATATG CGTGCTATGC TATTGGAAAG GATGTGCAAG CCATGAAAGC TGTCGTTGGA 
GAAGAAGCCC TTACCTCAGA TGATCTTCTC TACTTGGAAT TTCTGCAGAA GTTTGAGAGG 
AACTTCATTG CTCAGGGTCC TTACGAAAAT CGCACTGTCT TTGAGACTTT GGACATTGGC 
TGGCAGCTAC TCCGAATCTT CCCCAAAGAA ATGCTGAAGA GAATCCCTCA GAGCACCCTC 
AGCGAATTTT ACCCTCGAGA CTCTGCAAAG CATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001684.2
CDS	27..1562
Translation	MALRAMRGIVNGAAPELPVPTGGPAVGAREQALAVSRNYLSQPRLTYKTVSGVNGPLVILDHVKFPRYAEIVHLTLPDGTKRSGQVLEVSGSKAVVQVFEGTSGIDAKKTSCEFTGDILRTPVSEDMLGRVFNGSGKPIDRGPVVLAEDFLDIMGQPINPQCRIYPEEMIQTGISAIDGMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKKSKDVVDYSEENFAIVFAAMGVNMETARFFKSDFEENGSMDNVCLFLNLANDPTIERIITPRLALTTAEFLAYQCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIYVDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTRKDHADVSNQLYACYAIGKDVQAMKAVVGEEALTSDDLLYLEFLQKFERNFIAQGPYENRTVFETLDIGWQLLRIFPKEMLKRIPQSTLSEFYPRDSAKH

Target ORF information:

RefSeq Version	NM_001693.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ATPase H+ transporting V1 subunit B2 (ATP6V1B2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001693.4

ORF Insert Sequence:

ATGGCGCTGC GGGCGATGCG GGGGATTGTC AACGGGGCCG CACCCGAGCT ACCCGTGCCC 
ACCGGTGGGC CGGCGGTGGG AGCTCGGGAG CAGGCGCTGG CAGTCAGTCG GAACTACCTC 
TCCCAGCCTC GCCTCACATA CAAGACAGTA TCTGGAGTCA ATGGTCCACT AGTGATCTTA 
GATCATGTTA AGTTTCCCAG GTATGCTGAA ATTGTCCATT TGACCTTACC GGATGGCACA 
AAGAGAAGTG GGCAAGTTCT GGAAGTTAGT GGTTCCAAGG CAGTAGTTCA GGTATTTGAA 
GGGACTTCAG GTATAGATGC TAAGAAAACG TCCTGTGAGT TTACTGGGGA TATTCTCCGA 
ACACCGGTGT CTGAGGATAT GCTTGGTCGG GTATTCAATG GATCGGGAAA ACCCATTGAC 
AGAGGTCCTG TTGTACTGGC CGAAGACTTC CTTGATATCA TGGGTCAGCC AATCAACCCT 
CAATGTCGAA TCTACCCAGA GGAAATGATT CAGACTGGCA TTTCGGCCAT CGATGGGATG 
AACAGTATTG CTAGGGGGCA GAAAATTCCT ATCTTCTCTG CTGCTGGGCT ACCACACAAT 
GAGATTGCAG CTCAGATCTG TCGCCAGGCT GGTTTGGTAA AGAAATCCAA AGATGTAGTA 
GACTACAGTG AGGAAAATTT TGCAATTGTA TTTGCTGCTA TGGGTGTAAA CATGGAAACT 
GCCCGGTTCT TCAAATCTGA CTTTGAAGAA AATGGCTCAA TGGACAATGT CTGCCTCTTT 
TTGAACTTGG CTAATGACCC AACCATTGAG CGAATTATCA CTCCTCGCCT GGCTCTAACC 
ACAGCTGAAT TTCTGGCGTA CCAATGTGAG AAACATGTAT TGGTTATTCT AACAGACATG 
AGTTCTTATG CTGAAGCACT TCGAGAGGTT TCAGCAGCCA GGGAAGAGGT ACCTGGTCGA 
CGAGGTTTTC CAGGTTACAT GTATACAGAT TTAGCCACGA TATATGAACG CGCTGGGCGA 
GTGGAAGGGA GAAACGGCTC GATTACTCAA ATCCCTATTC TAACCATGCC TAATGATGAT 
ATCACTCACC CCATCCCAGA CTTGACTGGC TACATTACAG AGGGGCAGAT CTATGTGGAC 
AGACAGCTGC ACAACAGACA GATTTATCCA CCTATCAATG TGCTGCCCTC ACTATCACGG 
TTAATGAAGT CTGCTATTGG AGAAGGGATG ACCAGGAAGG ATCATGCCGA TGTATCTAAC 
CAGCTATATG CGTGCTATGC TATTGGAAAG GATGTGCAAG CCATGAAAGC TGTCGTTGGA 
GAAGAAGCCC TTACCTCAGA TGATCTTCTC TACTTGGAAT TTCTGCAGAA GTTTGAGAGG 
AACTTCATTG CTCAGGGTCC TTACGAAAAT CGCACTGTCT TTGAGACTTT GGACATTGGC 
TGGCAGCTAC TCCGAATCTT CCCCAAAGAA ATGCTGAAGA GAATCCCTCA GAGCACCCTC 
AGCGAATTTT ACCCTCGAGA CTCTGCAAAG CATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATP6V1B2 ( NM_001693.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001684.2 Homo sapiens ATPase H+ transporting V1 subunit B2 (ATP6V1B2), mRNA.

Price & Availability↑

CloneID	OHu02138
Clone ID Related Accession (Same CDS sequence)	NM_001693.4 , NM_001693.3
Accession Version	NM_001693.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1536bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-10
Organism	Homo sapiens(human)
Product	V-type proton ATPase subunit B, brain isoform
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC025853.17, BC030640.2, X62949.1 and BC007309.1. This sequence is a reference standard in the RefSeqGene project. On Feb 10, 2006 this sequence version replaced NM_001693.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.37208.1, SRR1660803.203406.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCGCTGC GGGCGATGCG GGGGATTGTC AACGGGGCCG CACCCGAGCT ACCCGTGCCC 
ACCGGTGGGC CGGCGGTGGG AGCTCGGGAG CAGGCGCTGG CAGTCAGTCG GAACTACCTC 
TCCCAGCCTC GCCTCACATA CAAGACAGTA TCTGGAGTCA ATGGTCCACT AGTGATCTTA 
GATCATGTTA AGTTTCCCAG GTATGCTGAA ATTGTCCATT TGACCTTACC GGATGGCACA 
AAGAGAAGTG GGCAAGTTCT GGAAGTTAGT GGTTCCAAGG CAGTAGTTCA GGTATTTGAA 
GGGACTTCAG GTATAGATGC TAAGAAAACG TCCTGTGAGT TTACTGGGGA TATTCTCCGA 
ACACCGGTGT CTGAGGATAT GCTTGGTCGG GTATTCAATG GATCGGGAAA ACCCATTGAC 
AGAGGTCCTG TTGTACTGGC CGAAGACTTC CTTGATATCA TGGGTCAGCC AATCAACCCT 
CAATGTCGAA TCTACCCAGA GGAAATGATT CAGACTGGCA TTTCGGCCAT CGATGGGATG 
AACAGTATTG CTAGGGGGCA GAAAATTCCT ATCTTCTCTG CTGCTGGGCT ACCACACAAT 
GAGATTGCAG CTCAGATCTG TCGCCAGGCT GGTTTGGTAA AGAAATCCAA AGATGTAGTA 
GACTACAGTG AGGAAAATTT TGCAATTGTA TTTGCTGCTA TGGGTGTAAA CATGGAAACT 
GCCCGGTTCT TCAAATCTGA CTTTGAAGAA AATGGCTCAA TGGACAATGT CTGCCTCTTT 
TTGAACTTGG CTAATGACCC AACCATTGAG CGAATTATCA CTCCTCGCCT GGCTCTAACC 
ACAGCTGAAT TTCTGGCGTA CCAATGTGAG AAACATGTAT TGGTTATTCT AACAGACATG 
AGTTCTTATG CTGAAGCACT TCGAGAGGTT TCAGCAGCCA GGGAAGAGGT ACCTGGTCGA 
CGAGGTTTTC CAGGTTACAT GTATACAGAT TTAGCCACGA TATATGAACG CGCTGGGCGA 
GTGGAAGGGA GAAACGGCTC GATTACTCAA ATCCCTATTC TAACCATGCC TAATGATGAT 
ATCACTCACC CCATCCCAGA CTTGACTGGC TACATTACAG AGGGGCAGAT CTATGTGGAC 
AGACAGCTGC ACAACAGACA GATTTATCCA CCTATCAATG TGCTGCCCTC ACTATCACGG 
TTAATGAAGT CTGCTATTGG AGAAGGGATG ACCAGGAAGG ATCATGCCGA TGTATCTAAC 
CAGCTATATG CGTGCTATGC TATTGGAAAG GATGTGCAAG CCATGAAAGC TGTCGTTGGA 
GAAGAAGCCC TTACCTCAGA TGATCTTCTC TACTTGGAAT TTCTGCAGAA GTTTGAGAGG 
AACTTCATTG CTCAGGGTCC TTACGAAAAT CGCACTGTCT TTGAGACTTT GGACATTGGC 
TGGCAGCTAC TCCGAATCTT CCCCAAAGAA ATGCTGAAGA GAATCCCTCA GAGCACCCTC 
AGCGAATTTT ACCCTCGAGA CTCTGCAAAG CATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001684.2
CDS	215..1750
Translation	MALRAMRGIVNGAAPELPVPTGGPAVGAREQALAVSRNYLSQPRLTYKTVSGVNGPLVILDHVKFPRYAEIVHLTLPDGTKRSGQVLEVSGSKAVVQVFEGTSGIDAKKTSCEFTGDILRTPVSEDMLGRVFNGSGKPIDRGPVVLAEDFLDIMGQPINPQCRIYPEEMIQTGISAIDGMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKKSKDVVDYSEENFAIVFAAMGVNMETARFFKSDFEENGSMDNVCLFLNLANDPTIERIITPRLALTTAEFLAYQCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIYVDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTRKDHADVSNQLYACYAIGKDVQAMKAVVGEEALTSDDLLYLEFLQKFERNFIAQGPYENRTVFETLDIGWQLLRIFPKEMLKRIPQSTLSEFYPRDSAKH

Target ORF information:

RefSeq Version	NM_001693.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ATPase H+ transporting V1 subunit B2 (ATP6V1B2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001693.3

ORF Insert Sequence:

ATGGCGCTGC GGGCGATGCG GGGGATTGTC AACGGGGCCG CACCCGAGCT ACCCGTGCCC 
ACCGGTGGGC CGGCGGTGGG AGCTCGGGAG CAGGCGCTGG CAGTCAGTCG GAACTACCTC 
TCCCAGCCTC GCCTCACATA CAAGACAGTA TCTGGAGTCA ATGGTCCACT AGTGATCTTA 
GATCATGTTA AGTTTCCCAG GTATGCTGAA ATTGTCCATT TGACCTTACC GGATGGCACA 
AAGAGAAGTG GGCAAGTTCT GGAAGTTAGT GGTTCCAAGG CAGTAGTTCA GGTATTTGAA 
GGGACTTCAG GTATAGATGC TAAGAAAACG TCCTGTGAGT TTACTGGGGA TATTCTCCGA 
ACACCGGTGT CTGAGGATAT GCTTGGTCGG GTATTCAATG GATCGGGAAA ACCCATTGAC 
AGAGGTCCTG TTGTACTGGC CGAAGACTTC CTTGATATCA TGGGTCAGCC AATCAACCCT 
CAATGTCGAA TCTACCCAGA GGAAATGATT CAGACTGGCA TTTCGGCCAT CGATGGGATG 
AACAGTATTG CTAGGGGGCA GAAAATTCCT ATCTTCTCTG CTGCTGGGCT ACCACACAAT 
GAGATTGCAG CTCAGATCTG TCGCCAGGCT GGTTTGGTAA AGAAATCCAA AGATGTAGTA 
GACTACAGTG AGGAAAATTT TGCAATTGTA TTTGCTGCTA TGGGTGTAAA CATGGAAACT 
GCCCGGTTCT TCAAATCTGA CTTTGAAGAA AATGGCTCAA TGGACAATGT CTGCCTCTTT 
TTGAACTTGG CTAATGACCC AACCATTGAG CGAATTATCA CTCCTCGCCT GGCTCTAACC 
ACAGCTGAAT TTCTGGCGTA CCAATGTGAG AAACATGTAT TGGTTATTCT AACAGACATG 
AGTTCTTATG CTGAAGCACT TCGAGAGGTT TCAGCAGCCA GGGAAGAGGT ACCTGGTCGA 
CGAGGTTTTC CAGGTTACAT GTATACAGAT TTAGCCACGA TATATGAACG CGCTGGGCGA 
GTGGAAGGGA GAAACGGCTC GATTACTCAA ATCCCTATTC TAACCATGCC TAATGATGAT 
ATCACTCACC CCATCCCAGA CTTGACTGGC TACATTACAG AGGGGCAGAT CTATGTGGAC 
AGACAGCTGC ACAACAGACA GATTTATCCA CCTATCAATG TGCTGCCCTC ACTATCACGG 
TTAATGAAGT CTGCTATTGG AGAAGGGATG ACCAGGAAGG ATCATGCCGA TGTATCTAAC 
CAGCTATATG CGTGCTATGC TATTGGAAAG GATGTGCAAG CCATGAAAGC TGTCGTTGGA 
GAAGAAGCCC TTACCTCAGA TGATCTTCTC TACTTGGAAT TTCTGCAGAA GTTTGAGAGG 
AACTTCATTG CTCAGGGTCC TTACGAAAAT CGCACTGTCT TTGAGACTTT GGACATTGGC 
TGGCAGCTAC TCCGAATCTT CCCCAAAGAA ATGCTGAAGA GAATCCCTCA GAGCACCCTC 
AGCGAATTTT ACCCTCGAGA CTCTGCAAAG CATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Changes in V-ATPase subunits of human urinary exosomes reflect the renal response to acute acid/alkali loading and the defects in distal renal tubular?acidosis.
Kidney international(2018 Jan)
Pathare G,Dhayat NA,Mohebbi N,Wagner CA,Bobulescu IA,Moe OW,Fuster DG

Association of ATP6V1B2 rs1106634 with lifetime risk of depression and hippocampal neurocognitive deficits: possible novel mechanisms in the etiopathology of depression.
Translational psychiatry6(11)e945(2016 11)
Gonda X,Eszlari N,Anderson IM,Deakin JF,Bagdy G,Juhasz G

Mutations in KCNH1 and ATP6V1B2 cause Zimmermann-Laband syndrome.
Nature genetics47(6)661-7(2015 Jun)
Kort?m F,Caputo V,Bauer CK,Stella L,Ciolfi A,Alawi M,Bocchinfuso G,Flex E,Paolacci S,Dentici ML,Grammatico P,Korenke GC,Leuzzi V,Mowat D,Nair LD,Nguyen TT,Thierry P,White SM,Dallapiccola B,Pizzuti A,Campeau PM,Tartaglia M,Kutsche K

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ATP6V1B2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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