ATP6V1B1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ATP6V1B1
Entrez Gene ID	525
Full Name	ATPase H+ transporting V1 subunit B1
Synonyms	ATP6B1,RTA1B,VATB,VMA2,VPP3
General protein information	Preferred Names ATPase H+ transporting V1 subunit B1 Names V-type proton ATPase subunit B, kidney isoform ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 H(+)-transporting two-sector ATPase, 58kD subunit H+-ATPase beta 1 subunit V-ATPase B1 subunit V-ATPase subunit B 1 endomembrane proton pump 58 kDa subunit vacuolar proton pump 3 vacuolar proton pump subunit B 1 vacuolar proton pump, subunit 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p13.3
Summary	This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain B subunit isoforms and is found in the kidney. Mutations in this gene cause distal renal tubular acidosis associated with sensorineural deafness. [provided by RefSeq, Jul 2008].
Disorder MIM:	192132
Disorder Html:	Renal tubular acidosis with deafness, 267300 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001692.3	NP_001683.2	V-type proton ATPase subunit B, kidney isoform
NM_001692.4	NP_001683.2	V-type proton ATPase subunit B, kidney isoform
XM_011532907.2	XP_011531209.1	V-type proton ATPase subunit B, kidney isoform isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ATP6V1B1	XP_001145161.1
Rattus norvegicus (Norway rat)	Atp6v1b1	NP_001101337.2
Danio rerio (zebrafish)	atp6v1ba	NP_878298.1
	ATP6V1B1	XP_001100824.1
Canis lupus familiaris (dog)	ATP6V1B1	XP_005626317.1
Bos taurus (cattle)	ATP6V1B1	NP_788827.1
Mus musculus (house mouse)	Atp6v1b1	NP_598918.1
Homo sapiens (human)	ATP6V1B1	NP_001683.2
Arabidopsis thaliana (thale cress)	AT4G38510	NP_195563.1
Xenopus tropicalis (tropical clawed frog)	atp6v1b1	NP_001107734.1
Caenorhabditis elegans (roundworm)	vha-12	NP_508711.1
Oryza sativa (rice)	Os01g0711000	NP_001044043.1

Gene Ontology
Bibliography

Related articles in PubMed

Changes in V-ATPase subunits of human urinary exosomes reflect the renal response to acute acid/alkali loading and the defects in distal renal tubular?acidosis.
Pathare G, Dhayat NA, Mohebbi N, Wagner CA, Bobulescu IA, Moe OW, Fuster DG
Kidney international(2018 Jan)

The genetic and clinical spectrum of a large cohort of patients with distal renal tubular acidosis.
Palazzo V, Provenzano A, Becherucci F, Sansavini G, Mazzinghi B, Orlandini V, Giunti L, Roperto RM, Pantaleo M, Artuso R, Andreucci E, Bargiacchi S, Traficante G, Stagi S, Murer L, Benetti E, Emma F, Giordano M, Rivieri F, Colussi G, Penco S, Manfredini E, Caruso MR, Garavelli L, Andrulli S, Vergine G, Miglietti N, Mancini E, Malaventura C, Percesepe A, Grosso E, Materassi M, Romagnani P, Giglio S
Kidney international91(5)1243-1255(2017 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The aim of this work was to analyze the prevalence of genetic defects in SLC4A1, ATP6V0A4, and ATP6V1B1 genes and to assess the clinical phenotype of distal renal tubular acidosis patients that are eventually typical of the different genetic forms of the disease.
Title: The genetic and clinical spectrum of a large cohort of patients with distal renal tubular acidosis.

Our data indicate that recurrent stone formers with the vacuolar H(+)-ATPase B1 subunit p.E161K SNP exhibit a urinary acidification deficit with an increased prevalence of calcium phosphate-containing kidney stones
Title: The Vacuolar H+-ATPase B1 Subunit Polymorphism p.E161K Associates with Impaired Urinary Acidification in Recurrent Stone Formers.

ATP6V1B1 genetic mutations were detected in more than half of the families studied. Mutations in this gene therefore seem to be the most common causative factors in hearing loss associated with distal renal tubular acidosis in these families.
Title: Investigation of ATP6V1B1 and ATP6V0A4 genes causing hereditary hearing loss associated with distal renal tubular acidosis in ian families.

Two founder mutations in the ATP6V1B1 gene were found in 16/27 dRTA cases.
Title: Molecular investigation of distal renal tubular acidosis in Tunisia, evidence for founder mutations.

demonstration of renal acidification defects and nephrolithiasis in heterozygous carriers of a mutant B1 subunit that cannot be attributable to negative dominance; propose that heterozygosity may lead to mild real acidification defects due to haploinsufficiency
Title: Incomplete distal renal tubular acidosis from a heterozygous mutation of the V-ATPase B1 subunit.

The following ATP6V1B1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ATP6V1B1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23172	NM_001692.4 Latest version!	Homo sapiens ATPase H+ transporting V1 subunit B1 (ATP6V1B1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu56426	XM_011532907.2 Latest version!	Homo sapiens ATPase H+ transporting V1 subunit B1 (ATP6V1B1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
View Old Accession Versions >>
OHu23172	NM_001692.3	Homo sapiens ATPase H+ transporting V1 subunit B1 (ATP6V1B1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ATP6V1B1 ( NM_001692.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001683.2 Homo sapiens ATPase H+ transporting V1 subunit B1 (ATP6V1B1), mRNA.

Price & Availability↑

CloneID	OHu23172
Clone ID Related Accession (Same CDS sequence)	NM_001692.3 , NM_001692.4
Accession Version	NM_001692.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1542bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	V-type proton ATPase subunit B, kidney isoform
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA845716.1, AC007040.2 and CA944873.1. This sequence is a reference standard in the RefSeqGene project. On Jan 27, 2006 this sequence version replaced NM_001692.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC063411.1, AK291121.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCATGG AGATAGACAG CAGGCCTGGG GGGCTCCCCG GCAGTAGCTG CAACCTAGGT 
GCAGCCCGAG AACACATGCA GGCGGTCACC CGAAACTACA TCACCCACCC CCGTGTCACC 
TACAGGACTG TGTGCAGCGT GAACGGGCCC CTGGTGGTGC TGGACCGGGT CAAGTTTGCC 
CAGTATGCGG AGATCGTCCA CTTCACCCTC CCAGATGGGA CTCAGAGGAG CGGGCAGGTG 
CTTGAGGTGG CTGGCACCAA GGCGATTGTT CAGGTGTTTG AAGGGACATC AGGGATCGAT 
GCCAGGAAGA CCACTTGCGA ATTTACAGGG GACATCCTAC GAACTCCGGT GTCAGAGGAC 
ATGCTGGGTC GGGTTTTCAA TGGCTCCGGC AAGCCCATTG ACAAGGGGCC AGTGGTCATG 
GCGGAGGACT TTCTGGATAT CAATGGCCAG CCCATCAACC CGCACTCCCG CATCTACCCC 
GAGGAGATGA TTCAGACGGG CATTTCTCCT ATTGACGTCA TGAACAGCAT TGCCCGCGGC 
CAGAAGATCC CCATCTTCTC AGCAGCCGGG CTCCCCCACA ATGAGATTGC CGCTCAGATC 
TGCCGCCAGG CGGGGCTGGT GAAGAAGTCC AAGGCTGTGC TGGATTACCA TGACGACAAC 
TTCGCCATCG TCTTTGCAGC CATGGGGGTG AACATGGAGA CAGCCAGATT CTTCAAGTCT 
GACTTTGAGC AGAATGGAAC CATGGGGAAC GTCTGCCTCT TCCTGAACTT GGCCAATGAC 
CCCACGATCG AGCGGATCAT CACCCCGCGC CTGGCGCTGA CCACTGCTGA ATTCCTTGCC 
TACCAGTGTG AGAAGCATGT GCTGGTCATA CTGACGGACA TGAGTTCCTA TGCAGAGGCC 
TTGCGGGAGG TCTCTGCTGC TAGAGAGGAG GTGCCTGGGC GCCGAGGGTT TCCTGGATAT 
ATGTACACAG ACCTGGCCAC CATCTACGAG CGGGCGGGCC GCGTGGAGGG TCGGGGAGGA 
TCCATCACAC AGATCCCCAT CCTCACCATG CCCAACGACG ATATCACCCA CCCTATCCCA 
GACTTGACGG GCTTCATCAC AGAGGGACAG ATCTACGTGG ACAGACAGCT TCACAACAGA 
CAGATCTACC CCCCCATCAA CGTGCTCCCT TCCCTGTCGC GGCTGATGAA GTCAGCCATT 
GGGGAAGGCA TGACAAGAAA GGACCATGGA GATGTCTCCA ACCAGCTGTA CGCCTGCTAT 
GCCATCGGGA AGGACGTGCA GGCCATGAAG GCAGTAGTTG GGGAGGAGGC GCTCACCTCT 
GAGGACCTGC TCTACCTGGA ATTCCTGCAG AAGTTTGAGA AGAACTTCAT CAATCAGGGC 
CCCTACGAGA ACCGCTCGGT GTTCGAGTCG CTGGACCTGG GCTGGAAGCT GCTGCGCATC 
TTCCCCAAGG AGATGCTGAA GCGCATTCCG CAGGCCGTGA TCGACGAGTT CTATTCCCGC 
GAGGGGGCGC TGCAGGACCT CGCGCCTGAC ACTGCGCTCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001683.2
CDS	88..1629
Translation	MAMEIDSRPGGLPGSSCNLGAAREHMQAVTRNYITHPRVTYRTVCSVNGPLVVLDRVKFAQYAEIVHFTLPDGTQRSGQVLEVAGTKAIVQVFEGTSGIDARKTTCEFTGDILRTPVSEDMLGRVFNGSGKPIDKGPVVMAEDFLDINGQPINPHSRIYPEEMIQTGISPIDVMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKKSKAVLDYHDDNFAIVFAAMGVNMETARFFKSDFEQNGTMGNVCLFLNLANDPTIERIITPRLALTTAEFLAYQCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRGGSITQIPILTMPNDDITHPIPDLTGFITEGQIYVDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTRKDHGDVSNQLYACYAIGKDVQAMKAVVGEEALTSEDLLYLEFLQKFEKNFINQGPYENRSVFESLDLGWKLLRIFPKEMLKRIPQAVIDEFYSREGALQDLAPDTAL

Target ORF information:

RefSeq Version	NM_001692.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ATPase H+ transporting V1 subunit B1 (ATP6V1B1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001692.3

ORF Insert Sequence:

ATGGCCATGG AGATAGACAG CAGGCCTGGG GGGCTCCCCG GCAGTAGCTG CAACCTAGGT 
GCAGCCCGAG AACACATGCA GGCGGTCACC CGAAACTACA TCACCCACCC CCGTGTCACC 
TACAGGACTG TGTGCAGCGT GAACGGGCCC CTGGTGGTGC TGGACCGGGT CAAGTTTGCC 
CAGTATGCGG AGATCGTCCA CTTCACCCTC CCAGATGGGA CTCAGAGGAG CGGGCAGGTG 
CTTGAGGTGG CTGGCACCAA GGCGATTGTT CAGGTGTTTG AAGGGACATC AGGGATCGAT 
GCCAGGAAGA CCACTTGCGA ATTTACAGGG GACATCCTAC GAACTCCGGT GTCAGAGGAC 
ATGCTGGGTC GGGTTTTCAA TGGCTCCGGC AAGCCCATTG ACAAGGGGCC AGTGGTCATG 
GCGGAGGACT TTCTGGATAT CAATGGCCAG CCCATCAACC CGCACTCCCG CATCTACCCC 
GAGGAGATGA TTCAGACGGG CATTTCTCCT ATTGACGTCA TGAACAGCAT TGCCCGCGGC 
CAGAAGATCC CCATCTTCTC AGCAGCCGGG CTCCCCCACA ATGAGATTGC CGCTCAGATC 
TGCCGCCAGG CGGGGCTGGT GAAGAAGTCC AAGGCTGTGC TGGATTACCA TGACGACAAC 
TTCGCCATCG TCTTTGCAGC CATGGGGGTG AACATGGAGA CAGCCAGATT CTTCAAGTCT 
GACTTTGAGC AGAATGGAAC CATGGGGAAC GTCTGCCTCT TCCTGAACTT GGCCAATGAC 
CCCACGATCG AGCGGATCAT CACCCCGCGC CTGGCGCTGA CCACTGCTGA ATTCCTTGCC 
TACCAGTGTG AGAAGCATGT GCTGGTCATA CTGACGGACA TGAGTTCCTA TGCAGAGGCC 
TTGCGGGAGG TCTCTGCTGC TAGAGAGGAG GTGCCTGGGC GCCGAGGGTT TCCTGGATAT 
ATGTACACAG ACCTGGCCAC CATCTACGAG CGGGCGGGCC GCGTGGAGGG TCGGGGAGGA 
TCCATCACAC AGATCCCCAT CCTCACCATG CCCAACGACG ATATCACCCA CCCTATCCCA 
GACTTGACGG GCTTCATCAC AGAGGGACAG ATCTACGTGG ACAGACAGCT TCACAACAGA 
CAGATCTACC CCCCCATCAA CGTGCTCCCT TCCCTGTCGC GGCTGATGAA GTCAGCCATT 
GGGGAAGGCA TGACAAGAAA GGACCATGGA GATGTCTCCA ACCAGCTGTA CGCCTGCTAT 
GCCATCGGGA AGGACGTGCA GGCCATGAAG GCAGTAGTTG GGGAGGAGGC GCTCACCTCT 
GAGGACCTGC TCTACCTGGA ATTCCTGCAG AAGTTTGAGA AGAACTTCAT CAATCAGGGC 
CCCTACGAGA ACCGCTCGGT GTTCGAGTCG CTGGACCTGG GCTGGAAGCT GCTGCGCATC 
TTCCCCAAGG AGATGCTGAA GCGCATTCCG CAGGCCGTGA TCGACGAGTT CTATTCCCGC 
GAGGGGGCGC TGCAGGACCT CGCGCCTGAC ACTGCGCTCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATP6V1B1 ( NM_001692.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001683.2 Homo sapiens ATPase H+ transporting V1 subunit B1 (ATP6V1B1), mRNA.

Price & Availability↑

CloneID	OHu23172
Clone ID Related Accession (Same CDS sequence)	NM_001692.3 , NM_001692.4
Accession Version	NM_001692.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1542bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-15
Organism	Homo sapiens(human)
Product	V-type proton ATPase subunit B, kidney isoform
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK313194.1, BC063411.1 and AI769776.1. This sequence is a reference standard in the RefSeqGene project. On Sep 21, 2018 this sequence version replaced NM_001692.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC063411.1, AK291121.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000234396.10/ ENSP00000234396.4 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCATGG AGATAGACAG CAGGCCTGGG GGGCTCCCCG GCAGTAGCTG CAACCTAGGT 
GCAGCCCGAG AACACATGCA GGCGGTCACC CGAAACTACA TCACCCACCC CCGTGTCACC 
TACAGGACTG TGTGCAGCGT GAACGGGCCC CTGGTGGTGC TGGACCGGGT CAAGTTTGCC 
CAGTATGCGG AGATCGTCCA CTTCACCCTC CCAGATGGGA CTCAGAGGAG CGGGCAGGTG 
CTTGAGGTGG CTGGCACCAA GGCGATTGTT CAGGTGTTTG AAGGGACATC AGGGATCGAT 
GCCAGGAAGA CCACTTGCGA ATTTACAGGG GACATCCTAC GAACTCCGGT GTCAGAGGAC 
ATGCTGGGTC GGGTTTTCAA TGGCTCCGGC AAGCCCATTG ACAAGGGGCC AGTGGTCATG 
GCGGAGGACT TTCTGGATAT CAATGGCCAG CCCATCAACC CGCACTCCCG CATCTACCCC 
GAGGAGATGA TTCAGACGGG CATTTCTCCT ATTGACGTCA TGAACAGCAT TGCCCGCGGC 
CAGAAGATCC CCATCTTCTC AGCAGCCGGG CTCCCCCACA ATGAGATTGC CGCTCAGATC 
TGCCGCCAGG CGGGGCTGGT GAAGAAGTCC AAGGCTGTGC TGGATTACCA TGACGACAAC 
TTCGCCATCG TCTTTGCAGC CATGGGGGTG AACATGGAGA CAGCCAGATT CTTCAAGTCT 
GACTTTGAGC AGAATGGAAC CATGGGGAAC GTCTGCCTCT TCCTGAACTT GGCCAATGAC 
CCCACGATCG AGCGGATCAT CACCCCGCGC CTGGCGCTGA CCACTGCTGA ATTCCTTGCC 
TACCAGTGTG AGAAGCATGT GCTGGTCATA CTGACGGACA TGAGTTCCTA TGCAGAGGCC 
TTGCGGGAGG TCTCTGCTGC TAGAGAGGAG GTGCCTGGGC GCCGAGGGTT TCCTGGATAT 
ATGTACACAG ACCTGGCCAC CATCTACGAG CGGGCGGGCC GCGTGGAGGG TCGGGGAGGA 
TCCATCACAC AGATCCCCAT CCTCACCATG CCCAACGACG ATATCACCCA CCCTATCCCA 
GACTTGACGG GCTTCATCAC AGAGGGACAG ATCTACGTGG ACAGACAGCT TCACAACAGA 
CAGATCTACC CCCCCATCAA CGTGCTCCCT TCCCTGTCGC GGCTGATGAA GTCAGCCATT 
GGGGAAGGCA TGACAAGAAA GGACCATGGA GATGTCTCCA ACCAGCTGTA CGCCTGCTAT 
GCCATCGGGA AGGACGTGCA GGCCATGAAG GCAGTAGTTG GGGAGGAGGC GCTCACCTCT 
GAGGACCTGC TCTACCTGGA ATTCCTGCAG AAGTTTGAGA AGAACTTCAT CAATCAGGGC 
CCCTACGAGA ACCGCTCGGT GTTCGAGTCG CTGGACCTGG GCTGGAAGCT GCTGCGCATC 
TTCCCCAAGG AGATGCTGAA GCGCATTCCG CAGGCCGTGA TCGACGAGTT CTATTCCCGC 
GAGGGGGCGC TGCAGGACCT CGCGCCTGAC ACTGCGCTCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001683.2
CDS	56..1597
Translation	MAMEIDSRPGGLPGSSCNLGAAREHMQAVTRNYITHPRVTYRTVCSVNGPLVVLDRVKFAQYAEIVHFTLPDGTQRSGQVLEVAGTKAIVQVFEGTSGIDARKTTCEFTGDILRTPVSEDMLGRVFNGSGKPIDKGPVVMAEDFLDINGQPINPHSRIYPEEMIQTGISPIDVMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKKSKAVLDYHDDNFAIVFAAMGVNMETARFFKSDFEQNGTMGNVCLFLNLANDPTIERIITPRLALTTAEFLAYQCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRGGSITQIPILTMPNDDITHPIPDLTGFITEGQIYVDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTRKDHGDVSNQLYACYAIGKDVQAMKAVVGEEALTSEDLLYLEFLQKFEKNFINQGPYENRSVFESLDLGWKLLRIFPKEMLKRIPQAVIDEFYSREGALQDLAPDTAL

Target ORF information:

RefSeq Version	NM_001692.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ATPase H+ transporting V1 subunit B1 (ATP6V1B1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001692.4

ORF Insert Sequence:

ATGGCCATGG AGATAGACAG CAGGCCTGGG GGGCTCCCCG GCAGTAGCTG CAACCTAGGT 
GCAGCCCGAG AACACATGCA GGCGGTCACC CGAAACTACA TCACCCACCC CCGTGTCACC 
TACAGGACTG TGTGCAGCGT GAACGGGCCC CTGGTGGTGC TGGACCGGGT CAAGTTTGCC 
CAGTATGCGG AGATCGTCCA CTTCACCCTC CCAGATGGGA CTCAGAGGAG CGGGCAGGTG 
CTTGAGGTGG CTGGCACCAA GGCGATTGTT CAGGTGTTTG AAGGGACATC AGGGATCGAT 
GCCAGGAAGA CCACTTGCGA ATTTACAGGG GACATCCTAC GAACTCCGGT GTCAGAGGAC 
ATGCTGGGTC GGGTTTTCAA TGGCTCCGGC AAGCCCATTG ACAAGGGGCC AGTGGTCATG 
GCGGAGGACT TTCTGGATAT CAATGGCCAG CCCATCAACC CGCACTCCCG CATCTACCCC 
GAGGAGATGA TTCAGACGGG CATTTCTCCT ATTGACGTCA TGAACAGCAT TGCCCGCGGC 
CAGAAGATCC CCATCTTCTC AGCAGCCGGG CTCCCCCACA ATGAGATTGC CGCTCAGATC 
TGCCGCCAGG CGGGGCTGGT GAAGAAGTCC AAGGCTGTGC TGGATTACCA TGACGACAAC 
TTCGCCATCG TCTTTGCAGC CATGGGGGTG AACATGGAGA CAGCCAGATT CTTCAAGTCT 
GACTTTGAGC AGAATGGAAC CATGGGGAAC GTCTGCCTCT TCCTGAACTT GGCCAATGAC 
CCCACGATCG AGCGGATCAT CACCCCGCGC CTGGCGCTGA CCACTGCTGA ATTCCTTGCC 
TACCAGTGTG AGAAGCATGT GCTGGTCATA CTGACGGACA TGAGTTCCTA TGCAGAGGCC 
TTGCGGGAGG TCTCTGCTGC TAGAGAGGAG GTGCCTGGGC GCCGAGGGTT TCCTGGATAT 
ATGTACACAG ACCTGGCCAC CATCTACGAG CGGGCGGGCC GCGTGGAGGG TCGGGGAGGA 
TCCATCACAC AGATCCCCAT CCTCACCATG CCCAACGACG ATATCACCCA CCCTATCCCA 
GACTTGACGG GCTTCATCAC AGAGGGACAG ATCTACGTGG ACAGACAGCT TCACAACAGA 
CAGATCTACC CCCCCATCAA CGTGCTCCCT TCCCTGTCGC GGCTGATGAA GTCAGCCATT 
GGGGAAGGCA TGACAAGAAA GGACCATGGA GATGTCTCCA ACCAGCTGTA CGCCTGCTAT 
GCCATCGGGA AGGACGTGCA GGCCATGAAG GCAGTAGTTG GGGAGGAGGC GCTCACCTCT 
GAGGACCTGC TCTACCTGGA ATTCCTGCAG AAGTTTGAGA AGAACTTCAT CAATCAGGGC 
CCCTACGAGA ACCGCTCGGT GTTCGAGTCG CTGGACCTGG GCTGGAAGCT GCTGCGCATC 
TTCCCCAAGG AGATGCTGAA GCGCATTCCG CAGGCCGTGA TCGACGAGTT CTATTCCCGC 
GAGGGGGCGC TGCAGGACCT CGCGCCTGAC ACTGCGCTCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATP6V1B1 ( XM_011532907.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011531209.1 Homo sapiens ATPase H+ transporting V1 subunit B1 (ATP6V1B1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu56426
Clone ID Related Accession (Same CDS sequence)	XM_011532907.2
Accession Version	XM_011532907.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1662bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	V-type proton ATPase subunit B, kidney isoform isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011532907.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGGCCC AGCCCTGGGC CTTGGGAAAC CTCCTACTAT CCCTAACAAG CTGTCCTGCC 
TCCGTTTCCC TATCAGTGGC ATGGACGTAC CTAACCTCCT CAGAGGAAGG CTGGACCACA 
GCACGGCTGT ACCTAACCTC CTCGAGGGCT AGACTCTCCC CACCCTCGAC TCTCACAGGA 
TCTTCTTTTA ACGGGAAAGA GGAGGAGGTG GCAAGTCAAT GCCAACTAAA TTTTCTAGGG 
ATCTTGATGG CCTCCAAAGG CCTTTGGAAT ATCTCAGTCT CAGCAACATG GGTGTTTGCC 
CAGTATGCGG AGATCGTCCA CTTCACCCTC CCAGATGGGA CTCAGAGGAG CGGGCAGGTG 
CTTGAGGTGG CTGGCACCAA GGCGATTGTT CAGGTGTTTG AAGGGACATC AGGGATCGAT 
GCCAGGAAGA CCACTTGCGA ATTTACAGGG GACATCCTAC GAACTCCGGT GTCAGAGGAC 
ATGCTGGGTC GGGTTTTCAA TGGCTCCGGC AAGCCCATTG ACAAGGGGCC AGTGGTCATG 
GCGGAGGACT TTCTGGATAT CAATGGCCAG CCCATCAACC CGCACTCCCG CATCTACCCC 
GAGGAGATGA TTCAGACGGG CATTTCTCCT ATTGACGTCA TGAACAGCAT TGCCCGCGGC 
CAGAAGATCC CCATCTTCTC AGCAGCCGGG CTCCCCCACA ATGAGATTGC CGCTCAGATC 
TGCCGCCAGG CGGGGCTGGT GAAGAAGTCC AAGGCTGTGC TGGATTACCA TGACGACAAC 
TTCGCCATCG TCTTTGCAGC CATGGGGGTG AACATGGAGA CAGCCAGATT CTTCAAGTCT 
GACTTTGAGC AGAATGGAAC CATGGGGAAC GTCTGCCTCT TCCTGAACTT GGCCAATGAC 
CCCACGATCG AGCGGATCAT CACCCCGCGC CTGGCGCTGA CCACTGCTGA ATTCCTTGCC 
TACCAGTGTG AGAAGCATGT GCTGGTCATA CTGACGGACA TGAGTTCCTA TGCAGAGGCC 
TTGCGGGAGG TCTCTGCTGC TAGAGAGGAG GTGCCTGGGC GCCGAGGGTT TCCTGGATAT 
ATGTACACAG ACCTGGCCAC CATCTACGAG CGGGCGGGCC GCGTGGAGGG TCGGGGAGGA 
TCCATCACAC AGATCCCCAT CCTCACCATG CCCAACGACG ATATCACCCA CCCTATCCCA 
GACTTGACGG GCTTCATCAC AGAGGGACAG ATCTACGTGG ACAGACAGCT TCACAACAGA 
CAGATCTACC CCCCCATCAA CGTGCTCCCT TCCCTGTCGC GGCTGATGAA GTCAGCCATT 
GGGGAAGGCA TGACAAGAAA GGACCATGGA GATGTCTCCA ACCAGCTGTA CGCCTGCTAT 
GCCATCGGGA AGGACGTGCA GGCCATGAAG GCAGTAGTTG GGGAGGAGGC GCTCACCTCT 
GAGGACCTGC TCTACCTGGA ATTCCTGCAG AAGTTTGAGA AGAACTTCAT CAATCAGGGC 
CCCTACGAGA ACCGCTCGGT GTTCGAGTCG CTGGACCTGG GCTGGAAGCT GCTGCGCATC 
TTCCCCAAGG AGATGCTGAA GCGCATTCCG CAGGCCGTGA TCGACGAGTT CTATTCCCGC 
GAGGGGGCGC TGCAGGACCT CGCGCCTGAC ACTGCGCTCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011531209.1
CDS	180..1841
Translation	MEAQPWALGNLLLSLTSCPASVSLSVAWTYLTSSEEGWTTARLYLTSSRARLSPPSTLTGSSFNGKEEEVASQCQLNFLGILMASKGLWNISVSATWVFAQYAEIVHFTLPDGTQRSGQVLEVAGTKAIVQVFEGTSGIDARKTTCEFTGDILRTPVSEDMLGRVFNGSGKPIDKGPVVMAEDFLDINGQPINPHSRIYPEEMIQTGISPIDVMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKKSKAVLDYHDDNFAIVFAAMGVNMETARFFKSDFEQNGTMGNVCLFLNLANDPTIERIITPRLALTTAEFLAYQCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRGGSITQIPILTMPNDDITHPIPDLTGFITEGQIYVDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTRKDHGDVSNQLYACYAIGKDVQAMKAVVGEEALTSEDLLYLEFLQKFEKNFINQGPYENRSVFESLDLGWKLLRIFPKEMLKRIPQAVIDEFYSREGALQDLAPDTAL

Target ORF information:

RefSeq Version	XM_011532907.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ATPase H+ transporting V1 subunit B1 (ATP6V1B1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011532907.2

ORF Insert Sequence:

ATGGAGGCCC AGCCCTGGGC CTTGGGAAAC CTCCTACTAT CCCTAACAAG CTGTCCTGCC 
TCCGTTTCCC TATCAGTGGC ATGGACGTAC CTAACCTCCT CAGAGGAAGG CTGGACCACA 
GCACGGCTGT ACCTAACCTC CTCGAGGGCT AGACTCTCCC CACCCTCGAC TCTCACAGGA 
TCTTCTTTTA ACGGGAAAGA GGAGGAGGTG GCAAGTCAAT GCCAACTAAA TTTTCTAGGG 
ATCTTGATGG CCTCCAAAGG CCTTTGGAAT ATCTCAGTCT CAGCAACATG GGTGTTTGCC 
CAGTATGCGG AGATCGTCCA CTTCACCCTC CCAGATGGGA CTCAGAGGAG CGGGCAGGTG 
CTTGAGGTGG CTGGCACCAA GGCGATTGTT CAGGTGTTTG AAGGGACATC AGGGATCGAT 
GCCAGGAAGA CCACTTGCGA ATTTACAGGG GACATCCTAC GAACTCCGGT GTCAGAGGAC 
ATGCTGGGTC GGGTTTTCAA TGGCTCCGGC AAGCCCATTG ACAAGGGGCC AGTGGTCATG 
GCGGAGGACT TTCTGGATAT CAATGGCCAG CCCATCAACC CGCACTCCCG CATCTACCCC 
GAGGAGATGA TTCAGACGGG CATTTCTCCT ATTGACGTCA TGAACAGCAT TGCCCGCGGC 
CAGAAGATCC CCATCTTCTC AGCAGCCGGG CTCCCCCACA ATGAGATTGC CGCTCAGATC 
TGCCGCCAGG CGGGGCTGGT GAAGAAGTCC AAGGCTGTGC TGGATTACCA TGACGACAAC 
TTCGCCATCG TCTTTGCAGC CATGGGGGTG AACATGGAGA CAGCCAGATT CTTCAAGTCT 
GACTTTGAGC AGAATGGAAC CATGGGGAAC GTCTGCCTCT TCCTGAACTT GGCCAATGAC 
CCCACGATCG AGCGGATCAT CACCCCGCGC CTGGCGCTGA CCACTGCTGA ATTCCTTGCC 
TACCAGTGTG AGAAGCATGT GCTGGTCATA CTGACGGACA TGAGTTCCTA TGCAGAGGCC 
TTGCGGGAGG TCTCTGCTGC TAGAGAGGAG GTGCCTGGGC GCCGAGGGTT TCCTGGATAT 
ATGTACACAG ACCTGGCCAC CATCTACGAG CGGGCGGGCC GCGTGGAGGG TCGGGGAGGA 
TCCATCACAC AGATCCCCAT CCTCACCATG CCCAACGACG ATATCACCCA CCCTATCCCA 
GACTTGACGG GCTTCATCAC AGAGGGACAG ATCTACGTGG ACAGACAGCT TCACAACAGA 
CAGATCTACC CCCCCATCAA CGTGCTCCCT TCCCTGTCGC GGCTGATGAA GTCAGCCATT 
GGGGAAGGCA TGACAAGAAA GGACCATGGA GATGTCTCCA ACCAGCTGTA CGCCTGCTAT 
GCCATCGGGA AGGACGTGCA GGCCATGAAG GCAGTAGTTG GGGAGGAGGC GCTCACCTCT 
GAGGACCTGC TCTACCTGGA ATTCCTGCAG AAGTTTGAGA AGAACTTCAT CAATCAGGGC 
CCCTACGAGA ACCGCTCGGT GTTCGAGTCG CTGGACCTGG GCTGGAAGCT GCTGCGCATC 
TTCCCCAAGG AGATGCTGAA GCGCATTCCG CAGGCCGTGA TCGACGAGTT CTATTCCCGC 
GAGGGGGCGC TGCAGGACCT CGCGCCTGAC ACTGCGCTCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Changes in V-ATPase subunits of human urinary exosomes reflect the renal response to acute acid/alkali loading and the defects in distal renal tubular?acidosis.
Kidney international(2018 Jan)
Pathare G,Dhayat NA,Mohebbi N,Wagner CA,Bobulescu IA,Moe OW,Fuster DG

The genetic and clinical spectrum of a large cohort of patients with distal renal tubular acidosis.
Kidney international91(5)1243-1255(2017 May)
Palazzo V,Provenzano A,Becherucci F,Sansavini G,Mazzinghi B,Orlandini V,Giunti L,Roperto RM,Pantaleo M,Artuso R,Andreucci E,Bargiacchi S,Traficante G,Stagi S,Murer L,Benetti E,Emma F,Giordano M,Rivieri F,Colussi G,Penco S,Manfredini E,Caruso MR,Garavelli L,Andrulli S,Vergine G,Miglietti N,Mancini E,Malaventura C,Percesepe A,Grosso E,Materassi M,Romagnani P,Giglio S

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ATP6V1B1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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