PGAM2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PGAM2
Entrez Gene ID	5224
Full Name	phosphoglycerate mutase 2
Synonyms	GSD10,PGAM-M,PGAMM
General protein information	Preferred Names phosphoglycerate mutase 2 Names phosphoglycerate mutase 2 BPG-dependent PGAM 2 muscle-specific phosphoglycerate mutase phosphoglycerate mutase 2 (muscle) phosphoglycerate mutase isozyme M
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7p13
Summary	Phosphoglycerate mutase (PGAM) catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. The PGAM is a dimeric enzyme containing, in different tissues, different proportions of a slow-migrating muscle (MM) isozyme, a fast-migrating brain (BB) isozyme, and a hybrid form (MB). This gene encodes muscle-specific PGAM subunit. Mutations in this gene cause muscle phosphoglycerate mutase eficiency, also known as glycogen storage disease X. [provided by RefSeq, Sep 2009].
Disorder MIM:	612931
Disorder Html:	Glycogen storage disease X, 261670 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000290.4	NP_000281.2	phosphoglycerate mutase 2
NM_000290.3	NP_000281.2	phosphoglycerate mutase 2

Pathways from BioSystems

Homologies

Bos taurus (cattle)	PGAM2	NP_001033200.1
Pan troglodytes (chimpanzee)	PGAM2	XP_001143059.1
Canis lupus familiaris (dog)	PGAM2	XP_532718.2
Mus musculus (house mouse)	Pgam2	NP_061358.1
Kluyveromyces lactis	KLLA0E11859g	XP_454486.1
Eremothecium gossypii	AGOS_ACR056W	NP_983459.2
Xenopus tropicalis (tropical clawed frog)	pgam2	NP_001005665.1
Danio rerio (zebrafish)	pgam2	NP_957318.1
Homo sapiens (human)	PGAM2	NP_000281.2
Rattus norvegicus (Norway rat)	Pgam2	NP_059024.1
Saccharomyces cerevisiae (baker's yeast)	GPM1	NP_012770.1
	PGAM2	XP_001116220.1
Drosophila melanogaster (fruit fly)	Pglym87	NP_652041.2

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Oxidative stress activates SIRT2 to deacetylate and stimulate phosphoglycerate mutase.
Xu Y, Li F, Lv L, Li T, Zhou X, Deng CX, Guan KL, Lei QY, Xiong Y
Cancer research74(13)3630-42(2014 Jul)

Proteomic characterization of the human sperm nucleus.
de Mateo S, Castillo J, Estanyol JM, Ballesc? JL, Oliva R
Proteomics11(13)2714-26(2011 Jul)

Manifesting heterozygotes in a Japanese family with a novel mutation in the muscle-specific phosphoglycerate mutase (PGAM-M) gene.
Hadjigeorgiou GM, Kawashima N, Bruno C, Andreu AL, Sue CM, Rigden DJ, Kawashima A, Shanske S, DiMauro S
Neuromuscular disorders : NMD9(6-7)399-402(1999 Oct)

The molecular genetic basis of muscle phosphoglycerate mutase (PGAM) deficiency.
Tsujino S, Shanske S, Sakoda S, Fenichel G, DiMauro S
American journal of human genetics52(3)472-7(1993 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results reveal a mechanism of PGAM2 regulation and NADPH homeostasis in response to oxidative stress that impacts cell proliferation and tumor growth.
Title: Oxidative stress activates SIRT2 to deacetylate and stimulate phosphoglycerate mutase.

The following PGAM2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PGAM2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19214	NM_000290.4 Latest version!	Homo sapiens phosphoglycerate mutase 2 (PGAM2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu19214	NM_000290.3	Homo sapiens phosphoglycerate mutase 2 (PGAM2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PGAM2 ( NM_000290.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000281.2 Homo sapiens phosphoglycerate mutase 2 (PGAM2), mRNA.

Price & Availability↑

CloneID	OHu19214
Clone ID Related Accession (Same CDS sequence)	NM_000290.4 , NM_000290.3
Accession Version	NM_000290.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 762bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	phosphoglycerate mutase 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC001904.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_000290.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC001904.1, SRR5189655.214859.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000297283.4/ ENSP00000297283.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCACTC ACCGCCTCGT GATGGTCCGG CACGGCGAGA GCACATGGAA CCAGGAGAAC 
CGTTTCTGTG GCTGGTTCGA TGCAGAGCTG AGTGAAAAGG GGACCGAGGA GGCCAAGCGG 
GGAGCCAAGG CCATCAAGGA TGCCAAGATG GAGTTTGACA TCTGCTACAC GTCAGTGCTG 
AAGCGGGCCA TCCGCACCCT CTGGGCCATC CTGGACGGCA CGGACCAGAT GTGGCTGCCT 
GTGGTGCGCA CTTGGCGCCT CAATGAGCGG CATTACGGGG GCCTCACAGG CCTCAACAAG 
GCAGAAACGG CCGCCAAGCA CGGGGAGGAG CAGGTGAAGA TCTGGAGGCG CTCCTTCGAC 
ATCCCGCCGC CCCCGATGGA CGAGAAGCAC CCCTACTACA ACTCCATTAG CAAGGAGCGT 
CGGTACGCAG GCCTGAAGCC CGGGGAACTC CCCACCTGCG AGAGCCTCAA GGACACCATT 
GCCCGGGCCC TGCCCTTCTG GAACGAGGAG ATTGTTCCCC AGATCAAGGC CGGCAAGCGA 
GTGCTCATTG CAGCCCACGG GAACAGCCTG CGGGGCATTG TCAAGCACCT GGAAGGGATG 
TCAGACCAGG CGATCATGGA GCTGAACCTG CCCACGGGGA TCCCCATTGT GTATGAGCTG 
AACAAGGAGC TGAAGCCCAC CAAGCCCATG CAGTTCCTGG GTGATGAGGA AACGGTGCGG 
AAGGCCATGG AGGCTGTGGC TGCCCAGGGC AAGGCCAAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000281.2
CDS	39..800
Translation	MATHRLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVLKRAIRTLWAILDGTDQMWLPVVRTWRLNERHYGGLTGLNKAETAAKHGEEQVKIWRRSFDIPPPPMDEKHPYYNSISKERRYAGLKPGELPTCESLKDTIARALPFWNEEIVPQIKAGKRVLIAAHGNSLRGIVKHLEGMSDQAIMELNLPTGIPIVYELNKELKPTKPMQFLGDEETVRKAMEAVAAQGKAK

Target ORF information:

RefSeq Version	NM_000290.4
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphoglycerate mutase 2 (PGAM2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000290.4

ORF Insert Sequence:

ATGGCCACTC ACCGCCTCGT GATGGTCCGG CACGGCGAGA GCACATGGAA CCAGGAGAAC 
CGTTTCTGTG GCTGGTTCGA TGCAGAGCTG AGTGAAAAGG GGACCGAGGA GGCCAAGCGG 
GGAGCCAAGG CCATCAAGGA TGCCAAGATG GAGTTTGACA TCTGCTACAC GTCAGTGCTG 
AAGCGGGCCA TCCGCACCCT CTGGGCCATC CTGGACGGCA CGGACCAGAT GTGGCTGCCT 
GTGGTGCGCA CTTGGCGCCT CAATGAGCGG CATTACGGGG GCCTCACAGG CCTCAACAAG 
GCAGAAACGG CCGCCAAGCA CGGGGAGGAG CAGGTGAAGA TCTGGAGGCG CTCCTTCGAC 
ATCCCGCCGC CCCCGATGGA CGAGAAGCAC CCCTACTACA ACTCCATTAG CAAGGAGCGT 
CGGTACGCAG GCCTGAAGCC CGGGGAACTC CCCACCTGCG AGAGCCTCAA GGACACCATT 
GCCCGGGCCC TGCCCTTCTG GAACGAGGAG ATTGTTCCCC AGATCAAGGC CGGCAAGCGA 
GTGCTCATTG CAGCCCACGG GAACAGCCTG CGGGGCATTG TCAAGCACCT GGAAGGGATG 
TCAGACCAGG CGATCATGGA GCTGAACCTG CCCACGGGGA TCCCCATTGT GTATGAGCTG 
AACAAGGAGC TGAAGCCCAC CAAGCCCATG CAGTTCCTGG GTGATGAGGA AACGGTGCGG 
AAGGCCATGG AGGCTGTGGC TGCCCAGGGC AAGGCCAAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PGAM2 ( NM_000290.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000281.2 Homo sapiens phosphoglycerate mutase 2 (PGAM2), mRNA.

Price & Availability↑

CloneID	OHu19214
Clone ID Related Accession (Same CDS sequence)	NM_000290.4 , NM_000290.3
Accession Version	NM_000290.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 762bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	phosphoglycerate mutase 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CT002473.1 and BC001904.1. This sequence is a reference standard in the RefSeqGene project. On Sep 25, 2009 this sequence version replaced NM_000290.2. ##Evidence-Data-START## Transcript exon combination :: BC001904.1, SRR1803614.210160.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END##

ATGGCCACTC ACCGCCTCGT GATGGTCCGG CACGGCGAGA GCACATGGAA CCAGGAGAAC 
CGTTTCTGTG GCTGGTTCGA TGCAGAGCTG AGTGAAAAGG GGACCGAGGA GGCCAAGCGG 
GGAGCCAAGG CCATCAAGGA TGCCAAGATG GAGTTTGACA TCTGCTACAC GTCAGTGCTG 
AAGCGGGCCA TCCGCACCCT CTGGGCCATC CTGGACGGCA CGGACCAGAT GTGGCTGCCT 
GTGGTGCGCA CTTGGCGCCT CAATGAGCGG CATTACGGGG GCCTCACAGG CCTCAACAAG 
GCAGAAACGG CCGCCAAGCA CGGGGAGGAG CAGGTGAAGA TCTGGAGGCG CTCCTTCGAC 
ATCCCGCCGC CCCCGATGGA CGAGAAGCAC CCCTACTACA ACTCCATTAG CAAGGAGCGT 
CGGTACGCAG GCCTGAAGCC CGGGGAACTC CCCACCTGCG AGAGCCTCAA GGACACCATT 
GCCCGGGCCC TGCCCTTCTG GAACGAGGAG ATTGTTCCCC AGATCAAGGC CGGCAAGCGA 
GTGCTCATTG CAGCCCACGG GAACAGCCTG CGGGGCATTG TCAAGCACCT GGAAGGGATG 
TCAGACCAGG CGATCATGGA GCTGAACCTG CCCACGGGGA TCCCCATTGT GTATGAGCTG 
AACAAGGAGC TGAAGCCCAC CAAGCCCATG CAGTTCCTGG GTGATGAGGA AACGGTGCGG 
AAGGCCATGG AGGCTGTGGC TGCCCAGGGC AAGGCCAAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000281.2
CDS	59..820
Translation	MATHRLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVLKRAIRTLWAILDGTDQMWLPVVRTWRLNERHYGGLTGLNKAETAAKHGEEQVKIWRRSFDIPPPPMDEKHPYYNSISKERRYAGLKPGELPTCESLKDTIARALPFWNEEIVPQIKAGKRVLIAAHGNSLRGIVKHLEGMSDQAIMELNLPTGIPIVYELNKELKPTKPMQFLGDEETVRKAMEAVAAQGKAK

Target ORF information:

RefSeq Version	NM_000290.3
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphoglycerate mutase 2 (PGAM2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000290.3

ORF Insert Sequence:

ATGGCCACTC ACCGCCTCGT GATGGTCCGG CACGGCGAGA GCACATGGAA CCAGGAGAAC 
CGTTTCTGTG GCTGGTTCGA TGCAGAGCTG AGTGAAAAGG GGACCGAGGA GGCCAAGCGG 
GGAGCCAAGG CCATCAAGGA TGCCAAGATG GAGTTTGACA TCTGCTACAC GTCAGTGCTG 
AAGCGGGCCA TCCGCACCCT CTGGGCCATC CTGGACGGCA CGGACCAGAT GTGGCTGCCT 
GTGGTGCGCA CTTGGCGCCT CAATGAGCGG CATTACGGGG GCCTCACAGG CCTCAACAAG 
GCAGAAACGG CCGCCAAGCA CGGGGAGGAG CAGGTGAAGA TCTGGAGGCG CTCCTTCGAC 
ATCCCGCCGC CCCCGATGGA CGAGAAGCAC CCCTACTACA ACTCCATTAG CAAGGAGCGT 
CGGTACGCAG GCCTGAAGCC CGGGGAACTC CCCACCTGCG AGAGCCTCAA GGACACCATT 
GCCCGGGCCC TGCCCTTCTG GAACGAGGAG ATTGTTCCCC AGATCAAGGC CGGCAAGCGA 
GTGCTCATTG CAGCCCACGG GAACAGCCTG CGGGGCATTG TCAAGCACCT GGAAGGGATG 
TCAGACCAGG CGATCATGGA GCTGAACCTG CCCACGGGGA TCCCCATTGT GTATGAGCTG 
AACAAGGAGC TGAAGCCCAC CAAGCCCATG CAGTTCCTGG GTGATGAGGA AACGGTGCGG 
AAGGCCATGG AGGCTGTGGC TGCCCAGGGC AAGGCCAAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Oxidative stress activates SIRT2 to deacetylate and stimulate phosphoglycerate mutase.
Cancer research74(13)3630-42(2014 Jul)
Xu Y,Li F,Lv L,Li T,Zhou X,Deng CX,Guan KL,Lei QY,Xiong Y

Proteomic characterization of the human sperm nucleus.
Proteomics11(13)2714-26(2011 Jul)
de Mateo S,Castillo J,Estanyol JM,Ballesc? JL,Oliva R

Manifesting heterozygotes in a Japanese family with a novel mutation in the muscle-specific phosphoglycerate mutase (PGAM-M) gene.
Neuromuscular disorders : NMD9(6-7)399-402(1999 Oct)
Hadjigeorgiou GM,Kawashima N,Bruno C,Andreu AL,Sue CM,Rigden DJ,Kawashima A,Shanske S,DiMauro S

The molecular genetic basis of muscle phosphoglycerate mutase (PGAM) deficiency.
American journal of human genetics52(3)472-7(1993 Mar)
Tsujino S,Shanske S,Sakoda S,Fenichel G,DiMauro S

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PGAM2 cDNA ORF clone, Homo sapiens(human)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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