PFDN1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PFDN1
Entrez Gene ID	5201
Full Name	prefoldin subunit 1
Synonyms	PDF,PFD1
General protein information	Preferred Names prefoldin subunit 1 Names prefoldin subunit 1 prefoldin 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q31.3
Summary	This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008].
Disorder MIM:	604897

mRNA and Protein(s)

mRNA	Protein	Name
NM_002622.4	NP_002613.2	prefoldin subunit 1
NM_002622.5	NP_002613.2	prefoldin subunit 1
XM_005268465.3	XP_005268522.1	prefoldin subunit 1 isoform X1
XM_005268465.4	XP_005268522.1	prefoldin subunit 1 isoform X1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Pfdn1	NP_080303.1
Pan troglodytes (chimpanzee)	PFDN1	XP_517971.1
	PFDN1	XP_001086335.1
Rattus norvegicus (Norway rat)	Pfdn1	NP_001101897.1
Xenopus tropicalis (tropical clawed frog)	LOC100497275	XP_002937772.1
Homo sapiens (human)	PFDN1	NP_002613.2
Bos taurus (cattle)	PFDN1	NP_001071530.1
Gallus gallus (chicken)	PFDN1	NP_001264075.1
Danio rerio (zebrafish)	pfdn1	NP_001013362.1

Gene Ontology
Bibliography

Related articles in PubMed

Transethnic genome-wide scan identifies novel Alzheimer's disease loci.
Jun GR, Chung J, Mez J, Barber R, Beecham GW, Bennett DA, Buxbaum JD, Byrd GS, Carrasquillo MM, Crane PK, Cruchaga C, De Jager P, Ertekin-Taner N, Evans D, Fallin MD, Foroud TM, Friedland RP, Goate AM, Graff-Radford NR, Hendrie H, Hall KS, Hamilton-Nelson KL, Inzelberg R, Kamboh MI, Kauwe JSK, Kukull WA, Kunkle BW, Kuwano R, Larson EB, Logue MW, Manly JJ, Martin ER, Montine TJ, Mukherjee S, Naj A, Reiman EM, Reitz C, Sherva R, St George-Hyslop PH, Thornton T, Younkin SG, Vardarajan BN, Wang LS, Wendlund JR, Winslow AR, , Haines J, Mayeux R, Pericak-Vance MA, Schellenberg G, Lunetta KL, Farrer LA
Alzheimer's & dementia : the journal of the Alzheimer's Association13(7)727-738(2017 Jul)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Prefoldin 1 promotes EMT and lung cancer progression by suppressing cyclin A expression.
Wang D, Shi W, Tang Y, Liu Y, He K, Hu Y, Li J, Yang Y, Song J
Oncogene36(7)885-898(2017 Feb)

PFDN1, an indicator for colorectal cancer prognosis, enhances tumor cell proliferation and motility through cytoskeletal reorganization.
Wang P, Zhao J, Yang X, Guan S, Feng H, Han D, Lu J, Ou B, Jin R, Sun J, Zong Y, Feng B, Ma J, Lu A, Zheng M
Medical oncology (Northwood, London, England)32(12)264(2015 Dec)

Interaction of hepatitis C virus F protein with prefoldin 2 perturbs tubulin cytoskeleton organization.
Tsao ML, Chao CH, Yeh CT
Biochemical and biophysical research communications348(1)271-7(2006 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Genome-wide significant (GWS) associations in single-nucleotide polymorphism (SNP)-based tests (P < 5 x 10(-8)) were identified for SNPs in PFDN1/HBEGF, USP6NL/ECHDC3, and BZRAP1-AS1.
Title: Transethnic genome-wide scan identifies novel Alzheimer's disease loci.

High PFDN1 expression is associated with lung cancer progression.
Title: Prefoldin 1 promotes EMT and lung cancer progression by suppressing cyclin A expression.

Studied PFDN1 as prognosis indicator for colorectal cancer and investigated the functions of PFDN1 in colorectal cancer.
Title: PFDN1, an indicator for colorectal cancer prognosis, enhances tumor cell proliferation and motility through cytoskeletal reorganization.

antagonistic actions of PhLP3 and prefoldin serve to modulate CCT activity and play a key role in establishing a functional cytoskeleton in vivo
Title: PhLP3 modulates CCT-mediated actin and tubulin folding via ternary complexes with substrates.

The following PFDN1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PFDN1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu01298	NM_002622.5 Latest version!	Homo sapiens prefoldin subunit 1 (PFDN1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu39877	XM_005268465.4 Latest version!	Homo sapiens prefoldin subunit 1 (PFDN1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu01298	NM_002622.4	Homo sapiens prefoldin subunit 1 (PFDN1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu39877	XM_005268465.3	Homo sapiens prefoldin subunit 1 (PFDN1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PFDN1 ( NM_002622.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002613.2 Homo sapiens prefoldin subunit 1 (PFDN1), mRNA.

Price & Availability↑

CloneID	OHu01298
Clone ID Related Accession (Same CDS sequence)	NM_002622.4 , NM_002622.5
Accession Version	NM_002622.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 369bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Homo sapiens(human)
Product	prefoldin subunit 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG707314.1, AC011380.6 and AA910992.1. On Feb 28, 2006 this sequence version replaced NM_002622.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.428040.1, BC003620.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155550, SAMN03267763 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGCCC CCGTGGATCT AGAGCTGAAG AAGGCCTTCA CAGAGCTTCA AGCCAAAGTT 
ATTGACACTC AACAGAAGGT GAAGCTCGCA GACATACAGA TTGAACAGCT AAACAGAACG 
AAAAAGCATG CACATCTTAC AGATACAGAG ATCATGACTT TGGTAGATGA GACTAACATG 
TATGAAGGTG TAGGAAGAAT GTTTATTCTT CAGTCCAAGG AAGCAATTCA CAGTCAGCTG 
TTAGAGAAGC AGAAAATAGC AGAAGAAAAA ATTAAAGAAC TAGAACAGAA AAAGTCCTAC 
CTGGAGCGAA GCGTTAAGGA AGCTGAGGAC AACATCCGGG AGATGCTGAT GGCACGAAGG 
GCCCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002613.2
CDS	32..400
Translation	MAAPVDLELKKAFTELQAKVIDTQQKVKLADIQIEQLNRTKKHAHLTDTEIMTLVDETNMYEGVGRMFILQSKEAIHSQLLEKQKIAEEKIKELEQKKSYLERSVKEAEDNIREMLMARRAQ

Target ORF information:

RefSeq Version	NM_002622.4
Organism	Homo sapiens(human)
Definition	Homo sapiens prefoldin subunit 1 (PFDN1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002622.4

ORF Insert Sequence:

ATGGCCGCCC CCGTGGATCT AGAGCTGAAG AAGGCCTTCA CAGAGCTTCA AGCCAAAGTT 
ATTGACACTC AACAGAAGGT GAAGCTCGCA GACATACAGA TTGAACAGCT AAACAGAACG 
AAAAAGCATG CACATCTTAC AGATACAGAG ATCATGACTT TGGTAGATGA GACTAACATG 
TATGAAGGTG TAGGAAGAAT GTTTATTCTT CAGTCCAAGG AAGCAATTCA CAGTCAGCTG 
TTAGAGAAGC AGAAAATAGC AGAAGAAAAA ATTAAAGAAC TAGAACAGAA AAAGTCCTAC 
CTGGAGCGAA GCGTTAAGGA AGCTGAGGAC AACATCCGGG AGATGCTGAT GGCACGAAGG 
GCCCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PFDN1 ( NM_002622.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002613.2 Homo sapiens prefoldin subunit 1 (PFDN1), mRNA.

Price & Availability↑

CloneID	OHu01298
Clone ID Related Accession (Same CDS sequence)	NM_002622.4 , NM_002622.5
Accession Version	NM_002622.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 369bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	prefoldin subunit 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG707314.1, AC011380.6 and AA910992.1. On May 17, 2019 this sequence version replaced NM_002622.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7410570.252249.1, SRR3476690.14593.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155550, SAMN03267763 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000261813.9/ ENSP00000261813.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCGCCC CCGTGGATCT AGAGCTGAAG AAGGCCTTCA CAGAGCTTCA AGCCAAAGTT 
ATTGACACTC AACAGAAGGT GAAGCTCGCA GACATACAGA TTGAACAGCT AAACAGAACG 
AAAAAGCATG CACATCTTAC AGATACAGAG ATCATGACTT TGGTAGATGA GACTAACATG 
TATGAAGGTG TAGGAAGAAT GTTTATTCTT CAGTCCAAGG AAGCAATTCA CAGTCAGCTG 
TTAGAGAAGC AGAAAATAGC AGAAGAAAAA ATTAAAGAAC TAGAACAGAA AAAGTCCTAC 
CTGGAGCGAA GCGTTAAGGA AGCTGAGGAC AACATCCGGG AGATGCTGAT GGCACGAAGG 
GCCCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002613.2
CDS	29..397
Translation	MAAPVDLELKKAFTELQAKVIDTQQKVKLADIQIEQLNRTKKHAHLTDTEIMTLVDETNMYEGVGRMFILQSKEAIHSQLLEKQKIAEEKIKELEQKKSYLERSVKEAEDNIREMLMARRAQ

Target ORF information:

RefSeq Version	NM_002622.5
Organism	Homo sapiens(human)
Definition	Homo sapiens prefoldin subunit 1 (PFDN1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002622.5

ORF Insert Sequence:

ATGGCCGCCC CCGTGGATCT AGAGCTGAAG AAGGCCTTCA CAGAGCTTCA AGCCAAAGTT 
ATTGACACTC AACAGAAGGT GAAGCTCGCA GACATACAGA TTGAACAGCT AAACAGAACG 
AAAAAGCATG CACATCTTAC AGATACAGAG ATCATGACTT TGGTAGATGA GACTAACATG 
TATGAAGGTG TAGGAAGAAT GTTTATTCTT CAGTCCAAGG AAGCAATTCA CAGTCAGCTG 
TTAGAGAAGC AGAAAATAGC AGAAGAAAAA ATTAAAGAAC TAGAACAGAA AAAGTCCTAC 
CTGGAGCGAA GCGTTAAGGA AGCTGAGGAC AACATCCGGG AGATGCTGAT GGCACGAAGG 
GCCCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PFDN1 ( XM_005268465.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005268522.1 Homo sapiens prefoldin subunit 1 (PFDN1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu39877
Clone ID Related Accession (Same CDS sequence)	XM_005268465.3 , XM_005268465.4
Accession Version	XM_005268465.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 348bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	prefoldin subunit 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005268465.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCGCCC CCGTGGATCT AGAGCTGAAG AAGGCCTTCA CAGAGCTTCA AGCCAAAGTT 
ATTGACACTC AACAGAAGGT GAAGCTCGCA GACATACAGA TTGAACAGCT AAACAGAACG 
AAAAAGCATG CACATCTTAC AGATACAGAG ATCATGACTT TGGTAGATGA GACTAACATG 
TATGAAGGTG TAGGAAGAAT GTTTATTCTT CAGTCCAAGG AAGCAATTCA CAGTCAGCTG 
TTAGAGAAGC AGAAAATAGC AGAAGAAAAA ATTAAAGAAC TAGAAGTGGA GGCCAGTTAC 
TGCTTCAACC TAAAGTCAGC CTTCAACCTA AAGTCTGTTA TATTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005268522.1
CDS	69..416
Translation	MAAPVDLELKKAFTELQAKVIDTQQKVKLADIQIEQLNRTKKHAHLTDTEIMTLVDETNMYEGVGRMFILQSKEAIHSQLLEKQKIAEEKIKELEVEASYCFNLKSAFNLKSVIF

Target ORF information:

RefSeq Version	XM_005268465.3
Organism	Homo sapiens(human)
Definition	Homo sapiens prefoldin subunit 1 (PFDN1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005268465.3

ORF Insert Sequence:

ATGGCCGCCC CCGTGGATCT AGAGCTGAAG AAGGCCTTCA CAGAGCTTCA AGCCAAAGTT 
ATTGACACTC AACAGAAGGT GAAGCTCGCA GACATACAGA TTGAACAGCT AAACAGAACG 
AAAAAGCATG CACATCTTAC AGATACAGAG ATCATGACTT TGGTAGATGA GACTAACATG 
TATGAAGGTG TAGGAAGAAT GTTTATTCTT CAGTCCAAGG AAGCAATTCA CAGTCAGCTG 
TTAGAGAAGC AGAAAATAGC AGAAGAAAAA ATTAAAGAAC TAGAAGTGGA GGCCAGTTAC 
TGCTTCAACC TAAAGTCAGC CTTCAACCTA AAGTCTGTTA TATTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PFDN1 ( XM_005268465.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_005268522.1 Homo sapiens prefoldin subunit 1 (PFDN1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu39877
Clone ID Related Accession (Same CDS sequence)	XM_005268465.3 , XM_005268465.4
Accession Version	XM_005268465.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 348bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	prefoldin subunit 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005268465.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCGCCC CCGTGGATCT AGAGCTGAAG AAGGCCTTCA CAGAGCTTCA AGCCAAAGTT 
ATTGACACTC AACAGAAGGT GAAGCTCGCA GACATACAGA TTGAACAGCT AAACAGAACG 
AAAAAGCATG CACATCTTAC AGATACAGAG ATCATGACTT TGGTAGATGA GACTAACATG 
TATGAAGGTG TAGGAAGAAT GTTTATTCTT CAGTCCAAGG AAGCAATTCA CAGTCAGCTG 
TTAGAGAAGC AGAAAATAGC AGAAGAAAAA ATTAAAGAAC TAGAAGTGGA GGCCAGTTAC 
TGCTTCAACC TAAAGTCAGC CTTCAACCTA AAGTCTGTTA TATTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005268522.1
CDS	14..361
Translation	MAAPVDLELKKAFTELQAKVIDTQQKVKLADIQIEQLNRTKKHAHLTDTEIMTLVDETNMYEGVGRMFILQSKEAIHSQLLEKQKIAEEKIKELEVEASYCFNLKSAFNLKSVIF

Target ORF information:

RefSeq Version	XM_005268465.4
Organism	Homo sapiens(human)
Definition	Homo sapiens prefoldin subunit 1 (PFDN1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005268465.4

ORF Insert Sequence:

ATGGCCGCCC CCGTGGATCT AGAGCTGAAG AAGGCCTTCA CAGAGCTTCA AGCCAAAGTT 
ATTGACACTC AACAGAAGGT GAAGCTCGCA GACATACAGA TTGAACAGCT AAACAGAACG 
AAAAAGCATG CACATCTTAC AGATACAGAG ATCATGACTT TGGTAGATGA GACTAACATG 
TATGAAGGTG TAGGAAGAAT GTTTATTCTT CAGTCCAAGG AAGCAATTCA CAGTCAGCTG 
TTAGAGAAGC AGAAAATAGC AGAAGAAAAA ATTAAAGAAC TAGAAGTGGA GGCCAGTTAC 
TGCTTCAACC TAAAGTCAGC CTTCAACCTA AAGTCTGTTA TATTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Transethnic genome-wide scan identifies novel Alzheimer's disease loci.
Alzheimer's & dementia : the journal of the Alzheimer's Association13(7)727-738(2017 Jul)
Jun GR,Chung J,Mez J,Barber R,Beecham GW,Bennett DA,Buxbaum JD,Byrd GS,Carrasquillo MM,Crane PK,Cruchaga C,De Jager P,Ertekin-Taner N,Evans D,Fallin MD,Foroud TM,Friedland RP,Goate AM,Graff-Radford NR,Hendrie H,Hall KS,Hamilton-Nelson KL,Inzelberg R,Kamboh MI,Kauwe JSK,Kukull WA,Kunkle BW,Kuwano R,Larson EB,Logue MW,Manly JJ,Martin ER,Montine TJ,Mukherjee S,Naj A,Reiman EM,Reitz C,Sherva R,St George-Hyslop PH,Thornton T,Younkin SG,Vardarajan BN,Wang LS,Wendlund JR,Winslow AR,,Haines J,Mayeux R,Pericak-Vance MA,Schellenberg G,Lunetta KL,Farrer LA

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Prefoldin 1 promotes EMT and lung cancer progression by suppressing cyclin A expression.
Oncogene36(7)885-898(2017 Feb)
Wang D,Shi W,Tang Y,Liu Y,He K,Hu Y,Li J,Yang Y,Song J

PFDN1, an indicator for colorectal cancer prognosis, enhances tumor cell proliferation and motility through cytoskeletal reorganization.
Medical oncology (Northwood, London, England)32(12)264(2015 Dec)
Wang P,Zhao J,Yang X,Guan S,Feng H,Han D,Lu J,Ou B,Jin R,Sun J,Zong Y,Feng B,Ma J,Lu A,Zheng M

Interaction of hepatitis C virus F protein with prefoldin 2 perturbs tubulin cytoskeleton organization.
Biochemical and biophysical research communications348(1)271-7(2006 Sep)
Tsao ML,Chao CH,Yeh CT

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PFDN1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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