PF4V1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PF4V1
Entrez Gene ID	5197
Full Name	platelet factor 4 variant 1
Synonyms	CXCL4L1,CXCL4V1,PF4-ALT,PF4A,SCYB4V1
General protein information	Preferred Names platelet factor 4 variant 1 Names platelet factor 4 variant C-X-C motif chemokine 4 PF4alt PF4var1 platelet factor 4, variant 1 (PF4-like)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q13.3
Summary	The protein encoded by this gene is a chemokine that is highly similar to platelet factor 4. The encoded protein displays a strong antiangiogenic function and is regulated by chemokine (C-X-C motif) receptor 3. This protein also impairs tumor growth and can protect against blood-retinal barrier breakdown in diabetes patients. [provided by RefSeq, Nov 2015].
Disorder MIM:	173461

mRNA and Protein(s)

mRNA	Protein	Name
NM_002620.2	NP_002611.1	platelet factor 4 variant precursor
NM_002620.3	NP_002611.1	platelet factor 4 variant precursor
NM_002620.4	NP_002611.1	platelet factor 4 variant precursor

Pathways from BioSystems

Homologies

	PF4V1	XP_001102971.1
Homo sapiens (human)	PF4V1	NP_002611.1
Pan troglodytes (chimpanzee)	PF4V1	XP_001156146.1

Gene Ontology
Bibliography

Related articles in PubMed

Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation.
von Hundelshausen P, Agten SM, Eckardt V, Blanchet X, Schmitt MM, Ippel H, Neideck C, Bidzhekov K, Leberzammer J, Wichapong K, Faussner A, Drechsler M, Grommes J, van Geffen JP, Li H, Ortega-Gomez A, Megens RT, Naumann R, Dijkgraaf I, Nicolaes GA, D?ring Y, Soehnlein O, Lutgens E, Heemskerk JW, Koenen RR, Mayo KH, Hackeng TM, Weber C
Science translational medicine9(384)(2017 Apr)

The roles and potential therapeutic implications of CXCL4 and its variant CXCL4L1 in the pathogenesis of chronic liver allograft dysfunction.
Li J, Liu B, Yan LN, Lau WY
Cytokine & growth factor reviews26(1)67-74(2015 Feb)

The Chemokine Platelet Factor-4 Variant (PF-4var)/CXCL4L1 Inhibits Diabetes-Induced Blood-Retinal Barrier Breakdown.
Abu El-Asrar AM, Mohammad G, Nawaz MI, Abdelsaid M, Siddiquei MM, Alam K, Van den Eynde K, De Hertogh G, Opdenakker G, Al-Shabrawey M, Van Damme J, Struyf S
Investigative ophthalmology & visual science56(3)1956-64(2015 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CXCL4 and CXCL4L1 activated p38 MAPK, as well as Src kinase within 30 and 5 min, respectively. Extracellular signal-regulated kinase (ERK) phosphorylation occurred in activated lymphocytes.
Title: CXCL4L1 and CXCL4 signaling in human lymphatic and microvascular endothelial cells and activated lymphocytes: involvement of mitogen-activated protein (MAP) kinases, Src and p70S6 kinase.

Fibstatin and CXCL4L1 cooperate to inhibit endothelial cell proliferation, migration and tubulogenesis in vitro.
Title: CXCL4L1-fibstatin cooperation inhibits tumor angiogenesis, lymphangiogenesis and metastasis.

Structural insight into the novel functional properties of human CXCL4L1.
Title: Alternative C-terminal helix orientation alters chemokine function: structure of the anti-angiogenic chemokine, CXCL4L1.

PF-4var/CXCL4L1 predicts outcome in stable coronary artery disease patients with preserved left ventricular function
Title: PF-4var/CXCL4L1 predicts outcome in stable coronary artery disease patients with preserved left ventricular function.

Current knowledge on the role of CXCL4/PF-4 and CXCL4L1/PF-4var in physiological and pathological processes.
Title: The role of the CXC chemokines platelet factor-4 (CXCL4/PF-4) and its variant (CXCL4L1/PF-4var) in inflammation, angiogenesis and cancer.

The following PF4V1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PF4V1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25445	NM_002620.4 Latest version!	Homo sapiens platelet factor 4 variant 1 (PF4V1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu25445	NM_002620.2	Homo sapiens platelet factor 4 variant 1 (PF4V1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu25445	NM_002620.3	Homo sapiens platelet factor 4 variant 1 (PF4V1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PF4V1 ( NM_002620.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002611.1 Homo sapiens platelet factor 4 variant 1 (PF4V1), mRNA.

Price & Availability↑

CloneID	OHu25445
Clone ID Related Accession (Same CDS sequence)	NM_002620.2 , NM_002620.3 , NM_002620.4
Accession Version	NM_002620.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 315bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	platelet factor 4 variant precursor
Comment

ATGAGCTCCG CAGCCAGGTC CCGCCTCACC CGCGCCACCC GCCAGGAGAT GCTGTTCTTG 
GCGTTGCTGC TCCTGCCAGT TGTGGTCGCC TTCGCCAGAG CTGAAGCTGA AGAAGATGGG 
GACCTGCAGT GCCTGTGTGT GAAGACCACC TCCCAGGTCC GTCCCAGGCA CATCACCAGC 
CTGGAGGTGA TCAAGGCCGG ACCCCACTGC CCCACTGCCC AACTCATAGC CACGCTGAAG 
AATGGGAGGA AAATTTGCTT GGATCTGCAA GCCCTGCTGT ACAAGAAAAT CATTAAGGAA 
CATTTGGAGA GTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002611.1
Translation	MSSAARSRLTRATRQEMLFLALLLLPVVVAFARAEAEEDGDLQCLCVKTTSQVRPRHITSLEVIKAGPHCPTAQLIATLKNGRKICLDLQALLYKKIIKEHLES

Target ORF information:

RefSeq Version	NM_002620.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens platelet factor 4 variant 1 (PF4V1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002620.2

ORF Insert Sequence:

ATGAGCTCCG CAGCCAGGTC CCGCCTCACC CGCGCCACCC GCCAGGAGAT GCTGTTCTTG 
GCGTTGCTGC TCCTGCCAGT TGTGGTCGCC TTCGCCAGAG CTGAAGCTGA AGAAGATGGG 
GACCTGCAGT GCCTGTGTGT GAAGACCACC TCCCAGGTCC GTCCCAGGCA CATCACCAGC 
CTGGAGGTGA TCAAGGCCGG ACCCCACTGC CCCACTGCCC AACTCATAGC CACGCTGAAG 
AATGGGAGGA AAATTTGCTT GGATCTGCAA GCCCTGCTGT ACAAGAAAAT CATTAAGGAA 
CATTTGGAGA GTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PF4V1 ( NM_002620.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002611.1 Homo sapiens platelet factor 4 variant 1 (PF4V1), mRNA.

Price & Availability↑

CloneID	OHu25445
Clone ID Related Accession (Same CDS sequence)	NM_002620.2 , NM_002620.3 , NM_002620.4
Accession Version	NM_002620.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 315bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	platelet factor 4 variant precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC092438.5 and BC130653.1. On Nov 24, 2015 this sequence version replaced NM_002620.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279829.555.1, BC130653.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144333, SAMEA2144335 [ECO:0000348] ##Evidence-Data-END##

ATGAGCTCCG CAGCCAGGTC CCGCCTCACC CGCGCCACCC GCCAGGAGAT GCTGTTCTTG 
GCGTTGCTGC TCCTGCCAGT TGTGGTCGCC TTCGCCAGAG CTGAAGCTGA AGAAGATGGG 
GACCTGCAGT GCCTGTGTGT GAAGACCACC TCCCAGGTCC GTCCCAGGCA CATCACCAGC 
CTGGAGGTGA TCAAGGCCGG ACCCCACTGC CCCACTGCCC AACTCATAGC CACGCTGAAG 
AATGGGAGGA AAATTTGCTT GGATCTGCAA GCCCTGCTGT ACAAGAAAAT CATTAAGGAA 
CATTTGGAGA GTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002611.1
CDS	68..382
Translation	MSSAARSRLTRATRQEMLFLALLLLPVVVAFARAEAEEDGDLQCLCVKTTSQVRPRHITSLEVIKAGPHCPTAQLIATLKNGRKICLDLQALLYKKIIKEHLES

Target ORF information:

RefSeq Version	NM_002620.3
Organism	Homo sapiens(human)
Definition	Homo sapiens platelet factor 4 variant 1 (PF4V1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002620.3

ORF Insert Sequence:

ATGAGCTCCG CAGCCAGGTC CCGCCTCACC CGCGCCACCC GCCAGGAGAT GCTGTTCTTG 
GCGTTGCTGC TCCTGCCAGT TGTGGTCGCC TTCGCCAGAG CTGAAGCTGA AGAAGATGGG 
GACCTGCAGT GCCTGTGTGT GAAGACCACC TCCCAGGTCC GTCCCAGGCA CATCACCAGC 
CTGGAGGTGA TCAAGGCCGG ACCCCACTGC CCCACTGCCC AACTCATAGC CACGCTGAAG 
AATGGGAGGA AAATTTGCTT GGATCTGCAA GCCCTGCTGT ACAAGAAAAT CATTAAGGAA 
CATTTGGAGA GTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PF4V1 ( NM_002620.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002611.1 Homo sapiens platelet factor 4 variant 1 (PF4V1), mRNA.

Price & Availability↑

CloneID	OHu25445
Clone ID Related Accession (Same CDS sequence)	NM_002620.2 , NM_002620.3 , NM_002620.4
Accession Version	NM_002620.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 315bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	platelet factor 4 variant precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC092438.5 and BC130653.1. On Nov 22, 2018 this sequence version replaced NM_002620.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189655.25447.1, ERR279829.555.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144333, SAMEA2144335 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000226524.4/ ENSP00000226524.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGCTCCG CAGCCAGGTC CCGCCTCACC CGCGCCACCC GCCAGGAGAT GCTGTTCTTG 
GCGTTGCTGC TCCTGCCAGT TGTGGTCGCC TTCGCCAGAG CTGAAGCTGA AGAAGATGGG 
GACCTGCAGT GCCTGTGTGT GAAGACCACC TCCCAGGTCC GTCCCAGGCA CATCACCAGC 
CTGGAGGTGA TCAAGGCCGG ACCCCACTGC CCCACTGCCC AACTCATAGC CACGCTGAAG 
AATGGGAGGA AAATTTGCTT GGATCTGCAA GCCCTGCTGT ACAAGAAAAT CATTAAGGAA 
CATTTGGAGA GTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002611.1
CDS	68..382
Translation	MSSAARSRLTRATRQEMLFLALLLLPVVVAFARAEAEEDGDLQCLCVKTTSQVRPRHITSLEVIKAGPHCPTAQLIATLKNGRKICLDLQALLYKKIIKEHLES

Target ORF information:

RefSeq Version	NM_002620.4
Organism	Homo sapiens(human)
Definition	Homo sapiens platelet factor 4 variant 1 (PF4V1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002620.4

ORF Insert Sequence:

ATGAGCTCCG CAGCCAGGTC CCGCCTCACC CGCGCCACCC GCCAGGAGAT GCTGTTCTTG 
GCGTTGCTGC TCCTGCCAGT TGTGGTCGCC TTCGCCAGAG CTGAAGCTGA AGAAGATGGG 
GACCTGCAGT GCCTGTGTGT GAAGACCACC TCCCAGGTCC GTCCCAGGCA CATCACCAGC 
CTGGAGGTGA TCAAGGCCGG ACCCCACTGC CCCACTGCCC AACTCATAGC CACGCTGAAG 
AATGGGAGGA AAATTTGCTT GGATCTGCAA GCCCTGCTGT ACAAGAAAAT CATTAAGGAA 
CATTTGGAGA GTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation.
Science translational medicine9(384)(2017 Apr)
von Hundelshausen P,Agten SM,Eckardt V,Blanchet X,Schmitt MM,Ippel H,Neideck C,Bidzhekov K,Leberzammer J,Wichapong K,Faussner A,Drechsler M,Grommes J,van Geffen JP,Li H,Ortega-Gomez A,Megens RT,Naumann R,Dijkgraaf I,Nicolaes GA,D?ring Y,Soehnlein O,Lutgens E,Heemskerk JW,Koenen RR,Mayo KH,Hackeng TM,Weber C

The roles and potential therapeutic implications of CXCL4 and its variant CXCL4L1 in the pathogenesis of chronic liver allograft dysfunction.
Cytokine & growth factor reviews26(1)67-74(2015 Feb)
Li J,Liu B,Yan LN,Lau WY

The Chemokine Platelet Factor-4 Variant (PF-4var)/CXCL4L1 Inhibits Diabetes-Induced Blood-Retinal Barrier Breakdown.
Investigative ophthalmology & visual science56(3)1956-64(2015 Feb)
Abu El-Asrar AM,Mohammad G,Nawaz MI,Abdelsaid M,Siddiquei MM,Alam K,Van den Eynde K,De Hertogh G,Opdenakker G,Al-Shabrawey M,Van Damme J,Struyf S

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PF4V1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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