CALML5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CALML5
Entrez Gene ID	51806
Full Name	calmodulin like 5
Synonyms	CLSP
General protein information	Preferred Names calmodulin like 5 Names calmodulin-like protein 5 calmodulin-like skin protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10p15.1
Summary	This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a key enzyme in the terminal differentiation of keratinocytes. [provided by RefSeq, Jul 2008].
Disorder MIM:	605183

mRNA and Protein(s)

mRNA	Protein	Name
NM_017422.4	NP_059118.2	calmodulin-like protein 5
NM_017422.5	NP_059118.2	calmodulin-like protein 5

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Calml5	XP_344628.5
	CALML5	XP_001104766.1
Mus musculus (house mouse)	Calm4	NP_064420.2
Homo sapiens (human)	CALML5	NP_059118.2
Pan troglodytes (chimpanzee)	CALML5	XP_001144681.1
Canis lupus familiaris (dog)	CALML5	XP_005617235.1
Bos taurus (cattle)	CALML5	NP_001091518.1

Gene Ontology
Bibliography

Related articles in PubMed

CALML5 is a ZNF750- and TINCR-induced protein that binds stratifin to regulate epidermal differentiation.
Sun BK, Boxer LD, Ransohoff JD, Siprashvili Z, Qu K, Lopez-Pajares V, Hollmig ST, Khavari PA
Genes & development29(21)2225-30(2015 Nov)

Specific expression of k63-linked ubiquitination of calmodulin-like protein 5 in breast cancer of premenopausal patients.
Debald M, Schildberg FA, Linke A, Walgenbach K, Kuhn W, Hartmann G, Walgenbach-Br?nagel G
Journal of cancer research and clinical oncology139(12)2125-32(2013 Dec)

Calmodulin-like skin protein level increases in the differentiated epidermal layers in atopic dermatitis.
Donovan M, Ambach A, Thomas-Collignon A, Prado C, Bernard D, Jammayrac O, Gollnick H, de Lacharriere O
Experimental dermatology22(12)836-7(2013 Dec)

Secreted calmodulin-like skin protein inhibits neuronal death in cell-based Alzheimer's disease models via the heterotrimeric Humanin receptor.
Hashimoto Y, Nawa M, Kurita M, Tokizawa M, Iwamatsu A, Matsuoka M
Cell death & disease4e555(2013 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CALML5 interacts with SFN in suprabasal epidermis, cocontrols 13% of late differentiation genes, and modulates interaction of SFN to some of its binding partners.
Title: CALML5 is a ZNF750- and TINCR-induced protein that binds stratifin to regulate epidermal differentiation.

Ubiquitination of CALML5 in the nucleus is involved in the carcinogenesis of breast cancer in premenopausal women.
Title: Specific expression of k63-linked ubiquitination of calmodulin-like protein 5 in breast cancer of premenopausal patients.

CLSP is increased in the upper epidermis in exacerbated atopic dermatitis as compared to non-exacerbated atopic dermatitis and normal skin, revealing a role in re-establishing the epidermal barrier
Title: Calmodulin-like skin protein level increases in the differentiated epidermal layers in atopic dermatitis.

CLSP is a physiological heterotrimeric humanin receptor agonist.
Title: Secreted calmodulin-like skin protein inhibits neuronal death in cell-based Alzheimer's disease models via the heterotrimeric Humanin receptor.

The structure and dynamics of human calmodulin-like skin protein (CLSP) have been characterized by NMR spectroscopy.
Title: A structural and dynamic characterization of the EF-hand protein CLSP.

The following CALML5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CALML5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu11669	NM_017422.5 Latest version!	Homo sapiens calmodulin like 5 (CALML5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu11669	NM_017422.4	Homo sapiens calmodulin like 5 (CALML5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CALML5 ( NM_017422.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_059118.2 Homo sapiens calmodulin like 5 (CALML5), mRNA.

Price & Availability↑

CloneID	OHu11669
Clone ID Related Accession (Same CDS sequence)	NM_017422.4 , NM_017422.5
Accession Version	NM_017422.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 441bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-20
Organism	Homo sapiens(human)
Product	calmodulin-like protein 5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL732437.12 and AK222744.1. On Feb 11, 2009 this sequence version replaced NM_017422.3. ##Evidence-Data-START## Transcript is intronless :: AK222744.1 [ECO:0000345] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGGTG AGCTGACTCC TGAGGAGGAG GCCCAGTACA AAAAGGCTTT CTCCGCGGTT 
GACACGGATG GAAACGGCAC CATCAATGCC CAGGAGCTGG GCGCGGCGCT GAAGGCCACG 
GGCAAGAACC TCTCGGAGGC CCAGCTAAGG AAACTCATCT CCGAGGTTGA CAGCGACGGC 
GACGGCGAAA TCAGCTTCCA GGAGTTCCTG ACGGCGGCGA AGAAGGCCAG GGCCGGCCTG 
GAGGACCTGC AGGTCGCCTT CCGCGCCTTC GACCAGGATG GCGACGGCCA CATCACCGTG 
GACGAGCTCA GGCGGGCCAT GGCGGGGCTG GGGCAGCCGC TGCCGCAGGA GGAGCTGGAC 
GCCATGATCC GCGAGGCCGA CGTGGACCAG GACGGGCGGG TGAACTACGA GGAGTTCGCG 
AGGATGCTCG CCCAGGAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_059118.2
CDS	133..573
Translation	MAGELTPEEEAQYKKAFSAVDTDGNGTINAQELGAALKATGKNLSEAQLRKLISEVDSDGDGEISFQEFLTAAKKARAGLEDLQVAFRAFDQDGDGHITVDELRRAMAGLGQPLPQEELDAMIREADVDQDGRVNYEEFARMLAQE

Target ORF information:

RefSeq Version	NM_017422.4
Organism	Homo sapiens(human)
Definition	Homo sapiens calmodulin like 5 (CALML5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017422.4

ORF Insert Sequence:

ATGGCCGGTG AGCTGACTCC TGAGGAGGAG GCCCAGTACA AAAAGGCTTT CTCCGCGGTT 
GACACGGATG GAAACGGCAC CATCAATGCC CAGGAGCTGG GCGCGGCGCT GAAGGCCACG 
GGCAAGAACC TCTCGGAGGC CCAGCTAAGG AAACTCATCT CCGAGGTTGA CAGCGACGGC 
GACGGCGAAA TCAGCTTCCA GGAGTTCCTG ACGGCGGCGA AGAAGGCCAG GGCCGGCCTG 
GAGGACCTGC AGGTCGCCTT CCGCGCCTTC GACCAGGATG GCGACGGCCA CATCACCGTG 
GACGAGCTCA GGCGGGCCAT GGCGGGGCTG GGGCAGCCGC TGCCGCAGGA GGAGCTGGAC 
GCCATGATCC GCGAGGCCGA CGTGGACCAG GACGGGCGGG TGAACTACGA GGAGTTCGCG 
AGGATGCTCG CCCAGGAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CALML5 ( NM_017422.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_059118.2 Homo sapiens calmodulin like 5 (CALML5), mRNA.

Price & Availability↑

CloneID	OHu11669
Clone ID Related Accession (Same CDS sequence)	NM_017422.4 , NM_017422.5
Accession Version	NM_017422.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 441bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	calmodulin-like protein 5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL732437.12 and AK222744.1. On May 17, 2019 this sequence version replaced NM_017422.4. ##Evidence-Data-START## Transcript is intronless :: AK222744.1, BC039172.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000380332.5/ ENSP00000369689.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCGGTG AGCTGACTCC TGAGGAGGAG GCCCAGTACA AAAAGGCTTT CTCCGCGGTT 
GACACGGATG GAAACGGCAC CATCAATGCC CAGGAGCTGG GCGCGGCGCT GAAGGCCACG 
GGCAAGAACC TCTCGGAGGC CCAGCTAAGG AAACTCATCT CCGAGGTTGA CAGCGACGGC 
GACGGCGAAA TCAGCTTCCA GGAGTTCCTG ACGGCGGCGA AGAAGGCCAG GGCCGGCCTG 
GAGGACCTGC AGGTCGCCTT CCGCGCCTTC GACCAGGATG GCGACGGCCA CATCACCGTG 
GACGAGCTCA GGCGGGCCAT GGCGGGGCTG GGGCAGCCGC TGCCGCAGGA GGAGCTGGAC 
GCCATGATCC GCGAGGCCGA CGTGGACCAG GACGGGCGGG TGAACTACGA GGAGTTCGCG 
AGGATGCTCG CCCAGGAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_059118.2
CDS	133..573
Translation	MAGELTPEEEAQYKKAFSAVDTDGNGTINAQELGAALKATGKNLSEAQLRKLISEVDSDGDGEISFQEFLTAAKKARAGLEDLQVAFRAFDQDGDGHITVDELRRAMAGLGQPLPQEELDAMIREADVDQDGRVNYEEFARMLAQE

Target ORF information:

RefSeq Version	NM_017422.5
Organism	Homo sapiens(human)
Definition	Homo sapiens calmodulin like 5 (CALML5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017422.5

ORF Insert Sequence:

ATGGCCGGTG AGCTGACTCC TGAGGAGGAG GCCCAGTACA AAAAGGCTTT CTCCGCGGTT 
GACACGGATG GAAACGGCAC CATCAATGCC CAGGAGCTGG GCGCGGCGCT GAAGGCCACG 
GGCAAGAACC TCTCGGAGGC CCAGCTAAGG AAACTCATCT CCGAGGTTGA CAGCGACGGC 
GACGGCGAAA TCAGCTTCCA GGAGTTCCTG ACGGCGGCGA AGAAGGCCAG GGCCGGCCTG 
GAGGACCTGC AGGTCGCCTT CCGCGCCTTC GACCAGGATG GCGACGGCCA CATCACCGTG 
GACGAGCTCA GGCGGGCCAT GGCGGGGCTG GGGCAGCCGC TGCCGCAGGA GGAGCTGGAC 
GCCATGATCC GCGAGGCCGA CGTGGACCAG GACGGGCGGG TGAACTACGA GGAGTTCGCG 
AGGATGCTCG CCCAGGAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CALML5 is a ZNF750- and TINCR-induced protein that binds stratifin to regulate epidermal differentiation.
Genes & development29(21)2225-30(2015 Nov)
Sun BK,Boxer LD,Ransohoff JD,Siprashvili Z,Qu K,Lopez-Pajares V,Hollmig ST,Khavari PA

Specific expression of k63-linked ubiquitination of calmodulin-like protein 5 in breast cancer of premenopausal patients.
Journal of cancer research and clinical oncology139(12)2125-32(2013 Dec)
Debald M,Schildberg FA,Linke A,Walgenbach K,Kuhn W,Hartmann G,Walgenbach-Br?nagel G

Calmodulin-like skin protein level increases in the differentiated epidermal layers in atopic dermatitis.
Experimental dermatology22(12)836-7(2013 Dec)
Donovan M,Ambach A,Thomas-Collignon A,Prado C,Bernard D,Jammayrac O,Gollnick H,de Lacharriere O

Secreted calmodulin-like skin protein inhibits neuronal death in cell-based Alzheimer's disease models via the heterotrimeric Humanin receptor.
Cell death & disease4e555(2013 Mar)
Hashimoto Y,Nawa M,Kurita M,Tokizawa M,Iwamatsu A,Matsuoka M

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CALML5 cDNA ORF clone, Homo sapiens(human)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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