ATP5MC3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ATP5MC3
Entrez Gene ID	518
Full Name	ATP synthase membrane subunit c locus 3
Synonyms	ATP5G3,P3
General protein information	Preferred Names ATP synthase membrane subunit c locus 3 Names ATP synthase F(0) complex subunit C3, mitochondrial ATP synthase lipid-binding protein, mitochondrial ATP synthase proteolipid P3 ATP synthase proton-transporting mitochondrial F(0) complex subunit C3 ATP synthase subunit 9 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9) ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) ATP synthase, mitochondrial, C subunit-3 ATPase protein 9 ATPase subunit C
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q31.1
Summary	This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene is one of three genes that encode subunit c of the proton channel. Each of the three genes have distinct mitochondrial import sequences but encode the identical mature protein. Alternatively spliced transcript variants encoding different proteins have been identified. [provided by RefSeq, Jun 2010].
Disorder MIM:	602736

mRNA and Protein(s)

mRNA	Protein	Name
NM_001002258.4	NP_001002258.1	ATP synthase F(0) complex subunit C3, mitochondrial isoform A precursor
NM_001190329.2	NP_001177258.1	ATP synthase F(0) complex subunit C3, mitochondrial isoform B precursor
NM_001190329.1	NP_001177258.1	ATP synthase F(0) complex subunit C3, mitochondrial isoform B precursor
NM_001689.4	NP_001680.1	ATP synthase F(0) complex subunit C3, mitochondrial isoform A precursor
NM_001002258.5	NP_001002258.1	ATP synthase F(0) complex subunit C3, mitochondrial isoform A precursor
NM_001689.5	NP_001680.1	ATP synthase F(0) complex subunit C3, mitochondrial isoform A precursor

Pathways from BioSystems

Homologies

	LOC706691	XP_002801696.1
Mus musculus (house mouse)	Atp5g3	NP_778180.1
Danio rerio (zebrafish)	atp5g3a	NP_957470.1
Pan troglodytes (chimpanzee)	ATP5G3	XP_525965.4
Rattus norvegicus (Norway rat)	Atp5g3	XP_006234456.1
Xenopus tropicalis (tropical clawed frog)	atp5g3	NP_001005087.1
Homo sapiens (human)	ATP5G3	NP_001680.1
Canis lupus familiaris (dog)	LOC478807	XP_535971.2
Bos taurus (cattle)	ATP5G3	NP_001029864.1
Gallus gallus (chicken)	ATP5G3	NP_001264784.1
Magnaporthe oryzae (rice blast fungus)	MGG_13815	XP_003710979.1

Gene Ontology
Bibliography

Related articles in PubMed

Persistence of the mitochondrial permeability transition in the absence of subunit c of human ATP synthase.
He J, Ford HC, Carroll J, Ding S, Fearnley IM, Walker JE
Proceedings of the National Academy of Sciences of the United States of America114(13)3409-3414(2017 Mar)

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)

Molecular motors: turning the ATP motor.
Cross RL
Nature427(6973)407-8(2004 Jan)

Energy transduction in the F1 motor of ATP synthase.
Wang H, Oster G
Nature396(6708)279-82(1998 Nov)

Energy transduction in ATP synthase.
Elston T, Wang H, Oster G
Nature391(6666)510-3(1998 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The following ATP5MC3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ATP5MC3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu08878	NM_001002258.5 Latest version!	Homo sapiens ATP synthase membrane subunit c locus 3 (ATP5MC3), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu08878	NM_001689.5 Latest version!	Homo sapiens ATP synthase membrane subunit c locus 3 (ATP5MC3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu12428	NM_001190329.2 Latest version!	Homo sapiens ATP synthase membrane subunit c locus 3 (ATP5MC3), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu12428	NM_001190329.1	Homo sapiens ATP synthase membrane subunit c locus 3 (ATP5MC3), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu08878	NM_001002258.4	Homo sapiens ATP synthase membrane subunit c locus 3 (ATP5MC3), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu08878	NM_001689.4	Homo sapiens ATP synthase membrane subunit c locus 3 (ATP5MC3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ATP5MC3 ( NM_001002258.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001002258.1 Homo sapiens ATP synthase membrane subunit c locus 3 (ATP5MC3), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu08878
Clone ID Related Accession (Same CDS sequence)	NM_001002258.4 , NM_001689.4 , NM_001002258.5 , NM_001689.5
Accession Version	NM_001002258.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-19
Organism	Homo sapiens(human)
Product	ATP synthase F(0) complex subunit C3, mitochondrial isoform A precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC096649.1, U09813.1 and AW025164.1. On Jun 28, 2007 this sequence version replaced NM_001002258.3. Transcript Variant: This variant (3) has multiple differences in the presence and absence of intron sequences at the 5' and 3' ends, compared to variant 4. These differences result in a protein (isoform A) with a longer C-terminus, compared to isoform B. Variants 2 and 3 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.43628.1, SRR1803612.151714.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTCGCCT GCGCCAAGCT CGCCTGCACC CCCTCTCTGA TCCGAGCTGG ATCCAGAGTT 
GCATACAGAC CAATTTCTGC ATCAGTGTTA TCTCGACCAG AGGCTAGTAG GACTGGAGAG 
GGCTCTACGG TATTTAATGG GGCCCAGAAT GGTGTGTCTC AGCTAATCCA AAGGGAGTTT 
CAGACCAGTG CAATCAGCAG AGACATTGAT ACTGCTGCCA AATTTATTGG TGCAGGTGCT 
GCAACAGTAG GAGTGGCTGG TTCTGGTGCT GGTATTGGAA CAGTCTTTGG CAGCCTTATC 
ATTGGTTATG CCAGAAACCC TTCGCTGAAG CAGCAGCTGT TCTCATATGC TATCCTGGGA 
TTTGCCTTGT CTGAAGCTAT GGGTCTCTTT TGTTTGATGG TTGCTTTCTT GATTTTGTTT 
GCCATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001002258.1
CDS	271..699
Translation	MFACAKLACTPSLIRAGSRVAYRPISASVLSRPEASRTGEGSTVFNGAQNGVSQLIQREFQTSAISRDIDTAAKFIGAGAATVGVAGSGAGIGTVFGSLIIGYARNPSLKQQLFSYAILGFALSEAMGLFCLMVAFLILFAM

Target ORF information:

RefSeq Version	NM_001002258.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ATP synthase membrane subunit c locus 3 (ATP5MC3), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001002258.4

ORF Insert Sequence:

ATGTTCGCCT GCGCCAAGCT CGCCTGCACC CCCTCTCTGA TCCGAGCTGG ATCCAGAGTT 
GCATACAGAC CAATTTCTGC ATCAGTGTTA TCTCGACCAG AGGCTAGTAG GACTGGAGAG 
GGCTCTACGG TATTTAATGG GGCCCAGAAT GGTGTGTCTC AGCTAATCCA AAGGGAGTTT 
CAGACCAGTG CAATCAGCAG AGACATTGAT ACTGCTGCCA AATTTATTGG TGCAGGTGCT 
GCAACAGTAG GAGTGGCTGG TTCTGGTGCT GGTATTGGAA CAGTCTTTGG CAGCCTTATC 
ATTGGTTATG CCAGAAACCC TTCGCTGAAG CAGCAGCTGT TCTCATATGC TATCCTGGGA 
TTTGCCTTGT CTGAAGCTAT GGGTCTCTTT TGTTTGATGG TTGCTTTCTT GATTTTGTTT 
GCCATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATP5MC3 ( NM_001689.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001680.1 Homo sapiens ATP synthase membrane subunit c locus 3 (ATP5MC3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu08878
Clone ID Related Accession (Same CDS sequence)	NM_001002258.4 , NM_001689.4 , NM_001002258.5 , NM_001689.5
Accession Version	NM_001689.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-20
Organism	Homo sapiens(human)
Product	ATP synthase F(0) complex subunit C3, mitochondrial isoform A precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BF210704.1, BI756002.1, BC106881.2, AC096649.1 and AW025164.1. On Jun 28, 2007 this sequence version replaced NM_001689.3. Transcript Variant: This variant (2) has an additional intron sequence in its 3' end, compared to variant 4. This difference results in a protein (isoform A) with a longer C-terminus, compared to isoform B. Variants 2 and 3 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.11510.1, SRR1660805.186432.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142680, SAMEA2144835 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTCGCCT GCGCCAAGCT CGCCTGCACC CCCTCTCTGA TCCGAGCTGG ATCCAGAGTT 
GCATACAGAC CAATTTCTGC ATCAGTGTTA TCTCGACCAG AGGCTAGTAG GACTGGAGAG 
GGCTCTACGG TATTTAATGG GGCCCAGAAT GGTGTGTCTC AGCTAATCCA AAGGGAGTTT 
CAGACCAGTG CAATCAGCAG AGACATTGAT ACTGCTGCCA AATTTATTGG TGCAGGTGCT 
GCAACAGTAG GAGTGGCTGG TTCTGGTGCT GGTATTGGAA CAGTCTTTGG CAGCCTTATC 
ATTGGTTATG CCAGAAACCC TTCGCTGAAG CAGCAGCTGT TCTCATATGC TATCCTGGGA 
TTTGCCTTGT CTGAAGCTAT GGGTCTCTTT TGTTTGATGG TTGCTTTCTT GATTTTGTTT 
GCCATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001680.1
CDS	181..609
Translation	MFACAKLACTPSLIRAGSRVAYRPISASVLSRPEASRTGEGSTVFNGAQNGVSQLIQREFQTSAISRDIDTAAKFIGAGAATVGVAGSGAGIGTVFGSLIIGYARNPSLKQQLFSYAILGFALSEAMGLFCLMVAFLILFAM

Target ORF information:

RefSeq Version	NM_001689.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ATP synthase membrane subunit c locus 3 (ATP5MC3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001689.4

ORF Insert Sequence:

ATGTTCGCCT GCGCCAAGCT CGCCTGCACC CCCTCTCTGA TCCGAGCTGG ATCCAGAGTT 
GCATACAGAC CAATTTCTGC ATCAGTGTTA TCTCGACCAG AGGCTAGTAG GACTGGAGAG 
GGCTCTACGG TATTTAATGG GGCCCAGAAT GGTGTGTCTC AGCTAATCCA AAGGGAGTTT 
CAGACCAGTG CAATCAGCAG AGACATTGAT ACTGCTGCCA AATTTATTGG TGCAGGTGCT 
GCAACAGTAG GAGTGGCTGG TTCTGGTGCT GGTATTGGAA CAGTCTTTGG CAGCCTTATC 
ATTGGTTATG CCAGAAACCC TTCGCTGAAG CAGCAGCTGT TCTCATATGC TATCCTGGGA 
TTTGCCTTGT CTGAAGCTAT GGGTCTCTTT TGTTTGATGG TTGCTTTCTT GATTTTGTTT 
GCCATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATP5MC3 ( NM_001002258.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001002258.1 Homo sapiens ATP synthase membrane subunit c locus 3 (ATP5MC3), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu08878
Clone ID Related Accession (Same CDS sequence)	NM_001002258.4 , NM_001689.4 , NM_001002258.5 , NM_001689.5
Accession Version	NM_001002258.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-02
Organism	Homo sapiens(human)
Product	ATP synthase F(0) complex subunit C3, mitochondrial isoform A precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC096649.1, U09813.1 and AW025164.1. On Jun 2, 2019 this sequence version replaced NM_001002258.4. Transcript Variant: This variant (3) has multiple differences in the presence and absence of intron sequences at the 5' and 3' ends, compared to variant 4. These differences result in a protein (isoform A) with a longer C-terminus, compared to isoform B. Variants 2 and 3 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.229627.1, SRR1803614.84317.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTCGCCT GCGCCAAGCT CGCCTGCACC CCCTCTCTGA TCCGAGCTGG ATCCAGAGTT 
GCATACAGAC CAATTTCTGC ATCAGTGTTA TCTCGACCAG AGGCTAGTAG GACTGGAGAG 
GGCTCTACGG TATTTAATGG GGCCCAGAAT GGTGTGTCTC AGCTAATCCA AAGGGAGTTT 
CAGACCAGTG CAATCAGCAG AGACATTGAT ACTGCTGCCA AATTTATTGG TGCAGGTGCT 
GCAACAGTAG GAGTGGCTGG TTCTGGTGCT GGTATTGGAA CAGTCTTTGG CAGCCTTATC 
ATTGGTTATG CCAGAAACCC TTCGCTGAAG CAGCAGCTGT TCTCATATGC TATCCTGGGA 
TTTGCCTTGT CTGAAGCTAT GGGTCTCTTT TGTTTGATGG TTGCTTTCTT GATTTTGTTT 
GCCATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001002258.1
CDS	318..746
Translation	MFACAKLACTPSLIRAGSRVAYRPISASVLSRPEASRTGEGSTVFNGAQNGVSQLIQREFQTSAISRDIDTAAKFIGAGAATVGVAGSGAGIGTVFGSLIIGYARNPSLKQQLFSYAILGFALSEAMGLFCLMVAFLILFAM

Target ORF information:

RefSeq Version	NM_001002258.5
Organism	Homo sapiens(human)
Definition	Homo sapiens ATP synthase membrane subunit c locus 3 (ATP5MC3), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001002258.5

ORF Insert Sequence:

ATGTTCGCCT GCGCCAAGCT CGCCTGCACC CCCTCTCTGA TCCGAGCTGG ATCCAGAGTT 
GCATACAGAC CAATTTCTGC ATCAGTGTTA TCTCGACCAG AGGCTAGTAG GACTGGAGAG 
GGCTCTACGG TATTTAATGG GGCCCAGAAT GGTGTGTCTC AGCTAATCCA AAGGGAGTTT 
CAGACCAGTG CAATCAGCAG AGACATTGAT ACTGCTGCCA AATTTATTGG TGCAGGTGCT 
GCAACAGTAG GAGTGGCTGG TTCTGGTGCT GGTATTGGAA CAGTCTTTGG CAGCCTTATC 
ATTGGTTATG CCAGAAACCC TTCGCTGAAG CAGCAGCTGT TCTCATATGC TATCCTGGGA 
TTTGCCTTGT CTGAAGCTAT GGGTCTCTTT TGTTTGATGG TTGCTTTCTT GATTTTGTTT 
GCCATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATP5MC3 ( NM_001689.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001680.1 Homo sapiens ATP synthase membrane subunit c locus 3 (ATP5MC3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu08878
Clone ID Related Accession (Same CDS sequence)	NM_001002258.4 , NM_001689.4 , NM_001002258.5 , NM_001689.5
Accession Version	NM_001689.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-02
Organism	Homo sapiens(human)
Product	ATP synthase F(0) complex subunit C3, mitochondrial isoform A precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BF210704.1, BI756002.1, BC106881.2, AC096649.1 and AW025164.1. On Jun 2, 2019 this sequence version replaced NM_001689.4. Transcript Variant: This variant (2) has an additional intron sequence in its 3' end, compared to variant 4. This difference results in a protein (isoform A) with a longer C-terminus, compared to isoform B. Variants 2 and 3 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.227951.1, SRR1803611.11510.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142680, SAMEA2144835 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTCGCCT GCGCCAAGCT CGCCTGCACC CCCTCTCTGA TCCGAGCTGG ATCCAGAGTT 
GCATACAGAC CAATTTCTGC ATCAGTGTTA TCTCGACCAG AGGCTAGTAG GACTGGAGAG 
GGCTCTACGG TATTTAATGG GGCCCAGAAT GGTGTGTCTC AGCTAATCCA AAGGGAGTTT 
CAGACCAGTG CAATCAGCAG AGACATTGAT ACTGCTGCCA AATTTATTGG TGCAGGTGCT 
GCAACAGTAG GAGTGGCTGG TTCTGGTGCT GGTATTGGAA CAGTCTTTGG CAGCCTTATC 
ATTGGTTATG CCAGAAACCC TTCGCTGAAG CAGCAGCTGT TCTCATATGC TATCCTGGGA 
TTTGCCTTGT CTGAAGCTAT GGGTCTCTTT TGTTTGATGG TTGCTTTCTT GATTTTGTTT 
GCCATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001680.1
CDS	129..557
Translation	MFACAKLACTPSLIRAGSRVAYRPISASVLSRPEASRTGEGSTVFNGAQNGVSQLIQREFQTSAISRDIDTAAKFIGAGAATVGVAGSGAGIGTVFGSLIIGYARNPSLKQQLFSYAILGFALSEAMGLFCLMVAFLILFAM

Target ORF information:

RefSeq Version	NM_001689.5
Organism	Homo sapiens(human)
Definition	Homo sapiens ATP synthase membrane subunit c locus 3 (ATP5MC3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001689.5

ORF Insert Sequence:

ATGTTCGCCT GCGCCAAGCT CGCCTGCACC CCCTCTCTGA TCCGAGCTGG ATCCAGAGTT 
GCATACAGAC CAATTTCTGC ATCAGTGTTA TCTCGACCAG AGGCTAGTAG GACTGGAGAG 
GGCTCTACGG TATTTAATGG GGCCCAGAAT GGTGTGTCTC AGCTAATCCA AAGGGAGTTT 
CAGACCAGTG CAATCAGCAG AGACATTGAT ACTGCTGCCA AATTTATTGG TGCAGGTGCT 
GCAACAGTAG GAGTGGCTGG TTCTGGTGCT GGTATTGGAA CAGTCTTTGG CAGCCTTATC 
ATTGGTTATG CCAGAAACCC TTCGCTGAAG CAGCAGCTGT TCTCATATGC TATCCTGGGA 
TTTGCCTTGT CTGAAGCTAT GGGTCTCTTT TGTTTGATGG TTGCTTTCTT GATTTTGTTT 
GCCATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATP5MC3 ( NM_001190329.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001177258.1 Homo sapiens ATP synthase membrane subunit c locus 3 (ATP5MC3), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu12428
Clone ID Related Accession (Same CDS sequence)	NM_001190329.2 , NM_001190329.1
Accession Version	NM_001190329.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 318bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-02
Organism	Homo sapiens(human)
Product	ATP synthase F(0) complex subunit C3, mitochondrial isoform B precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BF210704.1, BI765737.1, AC096649.1 and AW025164.1. On Jun 2, 2019 this sequence version replaced NM_001190329.1. Transcript Variant: This variant (4) represents the longest transcript but encodes a shorter protein (isoform B), compared to isoform A. Isoform B is predicted to lack a complete ATP synthase subunit C domain. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.194315.1, SRR1660807.234720.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTCGCCT GCGCCAAGCT CGCCTGCACC CCCTCTCTGA TCCGAGCTGG ATCCAGAGTT 
GCATACAGAC CAATTTCTGC ATCAGTGTTA TCTCGACCAG AGGCTAGTAG GACTGGAGAG 
GGCTCTACGG TATTTAATGG GGCCCAGAAT GGTGTGTCTC AGCTAATCCA AAGGGAGTTT 
CAGACCAGTG CAATCAGCAG AGACATTGAT ACTGCTGCCA AATTTATTGG TGCAGGTGCT 
GCAACAGTAG GAGTGGCTGG TTCTGGTGCT GGTATTGGAA CAGTCTTTGG CAGCCTTATC 
ATTGGTTATG CCAGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001177258.1
CDS	129..446
Translation	MFACAKLACTPSLIRAGSRVAYRPISASVLSRPEASRTGEGSTVFNGAQNGVSQLIQREFQTSAISRDIDTAAKFIGAGAATVGVAGSGAGIGTVFGSLIIGYAR

Target ORF information:

RefSeq Version	NM_001190329.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ATP synthase membrane subunit c locus 3 (ATP5MC3), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001190329.2

ORF Insert Sequence:

ATGTTCGCCT GCGCCAAGCT CGCCTGCACC CCCTCTCTGA TCCGAGCTGG ATCCAGAGTT 
GCATACAGAC CAATTTCTGC ATCAGTGTTA TCTCGACCAG AGGCTAGTAG GACTGGAGAG 
GGCTCTACGG TATTTAATGG GGCCCAGAAT GGTGTGTCTC AGCTAATCCA AAGGGAGTTT 
CAGACCAGTG CAATCAGCAG AGACATTGAT ACTGCTGCCA AATTTATTGG TGCAGGTGCT 
GCAACAGTAG GAGTGGCTGG TTCTGGTGCT GGTATTGGAA CAGTCTTTGG CAGCCTTATC 
ATTGGTTATG CCAGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATP5MC3 ( NM_001190329.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001177258.1 Homo sapiens ATP synthase membrane subunit c locus 3 (ATP5MC3), transcript variant 4, mRNA.

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CloneID	OHu12428
Clone ID Related Accession (Same CDS sequence)	NM_001190329.2 , NM_001190329.1
Accession Version	NM_001190329.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 318bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	ATP synthase F(0) complex subunit C3, mitochondrial isoform B precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BF210704.1, BI765737.1, AC096649.1 and AW025164.1. Transcript Variant: This variant (4) represents the longest transcript but encodes a shorter protein (isoform B), compared to isoform A. Isoform B is predicted to lack a complete ATP synthase subunit C domain. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.228750.1, SRR1660807.234720.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTCGCCT GCGCCAAGCT CGCCTGCACC CCCTCTCTGA TCCGAGCTGG ATCCAGAGTT 
GCATACAGAC CAATTTCTGC ATCAGTGTTA TCTCGACCAG AGGCTAGTAG GACTGGAGAG 
GGCTCTACGG TATTTAATGG GGCCCAGAAT GGTGTGTCTC AGCTAATCCA AAGGGAGTTT 
CAGACCAGTG CAATCAGCAG AGACATTGAT ACTGCTGCCA AATTTATTGG TGCAGGTGCT 
GCAACAGTAG GAGTGGCTGG TTCTGGTGCT GGTATTGGAA CAGTCTTTGG CAGCCTTATC 
ATTGGTTATG CCAGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001177258.1
CDS	181..498
Translation	MFACAKLACTPSLIRAGSRVAYRPISASVLSRPEASRTGEGSTVFNGAQNGVSQLIQREFQTSAISRDIDTAAKFIGAGAATVGVAGSGAGIGTVFGSLIIGYAR

Target ORF information:

RefSeq Version	NM_001190329.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ATP synthase membrane subunit c locus 3 (ATP5MC3), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001190329.1

ORF Insert Sequence:

ATGTTCGCCT GCGCCAAGCT CGCCTGCACC CCCTCTCTGA TCCGAGCTGG ATCCAGAGTT 
GCATACAGAC CAATTTCTGC ATCAGTGTTA TCTCGACCAG AGGCTAGTAG GACTGGAGAG 
GGCTCTACGG TATTTAATGG GGCCCAGAAT GGTGTGTCTC AGCTAATCCA AAGGGAGTTT 
CAGACCAGTG CAATCAGCAG AGACATTGAT ACTGCTGCCA AATTTATTGG TGCAGGTGCT 
GCAACAGTAG GAGTGGCTGG TTCTGGTGCT GGTATTGGAA CAGTCTTTGG CAGCCTTATC 
ATTGGTTATG CCAGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Persistence of the mitochondrial permeability transition in the absence of subunit c of human ATP synthase.
Proceedings of the National Academy of Sciences of the United States of America114(13)3409-3414(2017 Mar)
He J,Ford HC,Carroll J,Ding S,Fearnley IM,Walker JE

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ

Molecular motors: turning the ATP motor.
Nature427(6973)407-8(2004 Jan)
Cross RL

Energy transduction in the F1 motor of ATP synthase.
Nature396(6708)279-82(1998 Nov)
Wang H,Oster G

Energy transduction in ATP synthase.
Nature391(6666)510-3(1998 Jan)
Elston T,Wang H,Oster G

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ATP5MC3 cDNA ORF clone, Homo sapiens(human)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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