MYOZ2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MYOZ2
Entrez Gene ID	51778
Full Name	myozenin 2
Synonyms	C4orf5,CMH16,CS-1
General protein information	Preferred Names myozenin 2 Names myozenin-2 FATZ-related protein 2 calcineurin-binding protein calsarcin-1 muscle-specific protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q26
Summary	The protein encoded by this gene belongs to a family of sarcomeric proteins that bind to calcineurin, a phosphatase involved in calcium-dependent signal transduction in diverse cell types. These family members tether calcineurin to alpha-actinin at the z-line of the sarcomere of cardiac and skeletal muscle cells, and thus they are important for calcineurin signaling. Mutations in this gene cause cardiomyopathy familial hypertrophic type 16, a hereditary heart disorder. [provided by RefSeq, Aug 2011].
Disorder MIM:	605602
Disorder Html:	Cardiomyopathy, hypertrophic, 16, 613838 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_006714234.3	XP_006714297.1	myozenin-2 isoform X1
NM_016599.4	NP_057683.1	myozenin-2
XM_006714234.4	XP_006714297.1	myozenin-2 isoform X1
NM_016599.5	NP_057683.1	myozenin-2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MYOZ2	XP_001148878.1
Danio rerio (zebrafish)	myoz2b	NP_957148.2
Bos taurus (cattle)	MYOZ2	NP_001015676.1
Gallus gallus (chicken)	MYOZ2	NP_001264756.1
Canis lupus familiaris (dog)	MYOZ2	XP_535703.3
Xenopus tropicalis (tropical clawed frog)	myoz2	NP_001011415.1
Homo sapiens (human)	MYOZ2	NP_057683.1
	MYOZ2	XP_001098621.1
Mus musculus (house mouse)	Myoz2	NP_067478.1

Gene Ontology
Bibliography

Related articles in PubMed

Genetic anticipation in a special form of hypertrophic cardiomyopathy with sudden cardiac death in a family with 74 members across 5 generations.
Guo X, Fan C, Wang Y, Wang M, Cai C, Yang Y, Zhao S, Duan F, Li Y
Medicine96(11)e6249(2017 Mar)

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M
Cell164(4)805-17(2016 Feb)

Widespread macromolecular interaction perturbations in human genetic disorders.
Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kov?cs IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barab?si AL, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJM, Lindquist S, Vidal M
Cell161(3)647-660(2015 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

may play a modifying role in hypertrophic cardiomyopathy by affecting the penetrance or degree of performance of the MYH7 gene
Title: Genetic anticipation in a special form of hypertrophic cardiomyopathy with sudden cardiac death in a family with 74 members across 5 generations.

The cardiac phenotype in hypertrophic cardiomyopathy caused by MYOZ2 mutations might be independent of calcineurin activity in the heart.
Title: Pathogenesis of hypertrophic cardiomyopathy caused by myozenin 2 mutations is independent of calcineurin activity.

Observational study of gene-disease association. (HuGE Navigator)
Title: A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.

Observational study of gene-disease association. (HuGE Navigator)
Title: Candidate-gene testing for orphan limb-girdle muscular dystrophies.

Observational study of gene-disease association. (HuGE Navigator)
Title: Sequence analysis of myozenin 2 in 438 European patients with familial hypertrophic cardiomyopathy.

The following MYOZ2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MYOZ2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21456	NM_016599.5 Latest version!	Homo sapiens myozenin 2 (MYOZ2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu38965	XM_006714234.4 Latest version!	Homo sapiens myozenin 2 (MYOZ2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu38965	XM_006714234.3	Homo sapiens myozenin 2 (MYOZ2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu21456	NM_016599.4	Homo sapiens myozenin 2 (MYOZ2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MYOZ2 ( NM_016599.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057683.1 Homo sapiens myozenin 2 (MYOZ2), mRNA.

Price & Availability↑

CloneID	OHu21456
Clone ID Related Accession (Same CDS sequence)	NM_016599.4 , NM_016599.5
Accession Version	NM_016599.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 795bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	myozenin-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP370492.1, BC020932.1, AC092656.1 and BM091578.1. This sequence is a reference standard in the RefSeqGene project. On Aug 11, 2011 this sequence version replaced NM_016599.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY013295.1, SRR1803614.361267.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2144120 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTATCAC ATAATACTAT GATGAAGCAG AGAAAACAGC AAGCAACAGC CATCATGAAG 
GAAGTCCATG GAAATGATGT TGATGGCATG GACCTGGGCA AAAAGGTCAG CATCCCCAGA 
GACATCATGT TGGAAGAATT ATCCCATCTC AGTAACCGTG GTGCCAGGCT ATTTAAGATG 
CGTCAAAGAA GATCTGACAA ATACACATTT GAAAATTTCC AGTATCAATC TAGAGCACAA 
ATAAATCACA GTATTGCTAT GCAGAATGGG AAAGTGGATG GAAGTAACTT GGAAGGTGGT 
TCGCAGCAAG CCCCCTTGAC TCCTCCCAAC ACCCCAGATC CACGAAGCCC TCCAAATCCA 
GACAACATTG CTCCAGGATA TTCTGGACCA CTGAAGGAAA TTCCTCCTGA AAAATTCAAC 
ACCACAGCTG TCCCTAAGTA CTATCAATCT CCCTGGGAAC AAGCCATTAG CAATGATCCG 
GAGCTTTTAG AGGCTTTATA TCCTAAACTT TTCAAGCCTG AAGGAAAGGC AGAACTGCCT 
GATTACAGGA GCTTTAACAG GGTTGCCACA CCATTTGGAG GTTTTGAAAA AGCATCAAGA 
ATGGTTAAAT TTAAAGTTCC AGATTTTGAG CTACTATTGC TAACAGATCC CAGGTTTATG 
TCCTTTGTCA ATCCCCTTTC TGGCAGACGG TCCTTTAATA GGACTCCTAA GGGATGGATA 
TCTGAGAATA TTCCTATAGT GATAACAACC GAACCTACAG ATGATACCAC TGTACCAGAA 
TCAGAAGACC TATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057683.1
CDS	214..1008
Translation	MLSHNTMMKQRKQQATAIMKEVHGNDVDGMDLGKKVSIPRDIMLEELSHLSNRGARLFKMRQRRSDKYTFENFQYQSRAQINHSIAMQNGKVDGSNLEGGSQQAPLTPPNTPDPRSPPNPDNIAPGYSGPLKEIPPEKFNTTAVPKYYQSPWEQAISNDPELLEALYPKLFKPEGKAELPDYRSFNRVATPFGGFEKASRMVKFKVPDFELLLLTDPRFMSFVNPLSGRRSFNRTPKGWISENIPIVITTEPTDDTTVPESEDL

Target ORF information:

RefSeq Version	NM_016599.4
Organism	Homo sapiens(human)
Definition	Homo sapiens myozenin 2 (MYOZ2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016599.4

ORF Insert Sequence:

ATGCTATCAC ATAATACTAT GATGAAGCAG AGAAAACAGC AAGCAACAGC CATCATGAAG 
GAAGTCCATG GAAATGATGT TGATGGCATG GACCTGGGCA AAAAGGTCAG CATCCCCAGA 
GACATCATGT TGGAAGAATT ATCCCATCTC AGTAACCGTG GTGCCAGGCT ATTTAAGATG 
CGTCAAAGAA GATCTGACAA ATACACATTT GAAAATTTCC AGTATCAATC TAGAGCACAA 
ATAAATCACA GTATTGCTAT GCAGAATGGG AAAGTGGATG GAAGTAACTT GGAAGGTGGT 
TCGCAGCAAG CCCCCTTGAC TCCTCCCAAC ACCCCAGATC CACGAAGCCC TCCAAATCCA 
GACAACATTG CTCCAGGATA TTCTGGACCA CTGAAGGAAA TTCCTCCTGA AAAATTCAAC 
ACCACAGCTG TCCCTAAGTA CTATCAATCT CCCTGGGAAC AAGCCATTAG CAATGATCCG 
GAGCTTTTAG AGGCTTTATA TCCTAAACTT TTCAAGCCTG AAGGAAAGGC AGAACTGCCT 
GATTACAGGA GCTTTAACAG GGTTGCCACA CCATTTGGAG GTTTTGAAAA AGCATCAAGA 
ATGGTTAAAT TTAAAGTTCC AGATTTTGAG CTACTATTGC TAACAGATCC CAGGTTTATG 
TCCTTTGTCA ATCCCCTTTC TGGCAGACGG TCCTTTAATA GGACTCCTAA GGGATGGATA 
TCTGAGAATA TTCCTATAGT GATAACAACC GAACCTACAG ATGATACCAC TGTACCAGAA 
TCAGAAGACC TATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MYOZ2 ( NM_016599.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_057683.1 Homo sapiens myozenin 2 (MYOZ2), mRNA.

Price & Availability↑

CloneID	OHu21456
Clone ID Related Accession (Same CDS sequence)	NM_016599.4 , NM_016599.5
Accession Version	NM_016599.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 795bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	myozenin-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP370492.1, BC020932.1, AC092656.1 and BM091578.1. On Sep 24, 2019 this sequence version replaced NM_016599.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY013295.1, AJ252149.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTATCAC ATAATACTAT GATGAAGCAG AGAAAACAGC AAGCAACAGC CATCATGAAG 
GAAGTCCATG GAAATGATGT TGATGGCATG GACCTGGGCA AAAAGGTCAG CATCCCCAGA 
GACATCATGT TGGAAGAATT ATCCCATCTC AGTAACCGTG GTGCCAGGCT ATTTAAGATG 
CGTCAAAGAA GATCTGACAA ATACACATTT GAAAATTTCC AGTATCAATC TAGAGCACAA 
ATAAATCACA GTATTGCTAT GCAGAATGGG AAAGTGGATG GAAGTAACTT GGAAGGTGGT 
TCGCAGCAAG CCCCCTTGAC TCCTCCCAAC ACCCCAGATC CACGAAGCCC TCCAAATCCA 
GACAACATTG CTCCAGGATA TTCTGGACCA CTGAAGGAAA TTCCTCCTGA AAAATTCAAC 
ACCACAGCTG TCCCTAAGTA CTATCAATCT CCCTGGGAAC AAGCCATTAG CAATGATCCG 
GAGCTTTTAG AGGCTTTATA TCCTAAACTT TTCAAGCCTG AAGGAAAGGC AGAACTGCCT 
GATTACAGGA GCTTTAACAG GGTTGCCACA CCATTTGGAG GTTTTGAAAA AGCATCAAGA 
ATGGTTAAAT TTAAAGTTCC AGATTTTGAG CTACTATTGC TAACAGATCC CAGGTTTATG 
TCCTTTGTCA ATCCCCTTTC TGGCAGACGG TCCTTTAATA GGACTCCTAA GGGATGGATA 
TCTGAGAATA TTCCTATAGT GATAACAACC GAACCTACAG ATGATACCAC TGTACCAGAA 
TCAGAAGACC TATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057683.1
CDS	166..960
Translation	MLSHNTMMKQRKQQATAIMKEVHGNDVDGMDLGKKVSIPRDIMLEELSHLSNRGARLFKMRQRRSDKYTFENFQYQSRAQINHSIAMQNGKVDGSNLEGGSQQAPLTPPNTPDPRSPPNPDNIAPGYSGPLKEIPPEKFNTTAVPKYYQSPWEQAISNDPELLEALYPKLFKPEGKAELPDYRSFNRVATPFGGFEKASRMVKFKVPDFELLLLTDPRFMSFVNPLSGRRSFNRTPKGWISENIPIVITTEPTDDTTVPESEDL

Target ORF information:

RefSeq Version	NM_016599.5
Organism	Homo sapiens(human)
Definition	Homo sapiens myozenin 2 (MYOZ2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016599.5

ORF Insert Sequence:

ATGCTATCAC ATAATACTAT GATGAAGCAG AGAAAACAGC AAGCAACAGC CATCATGAAG 
GAAGTCCATG GAAATGATGT TGATGGCATG GACCTGGGCA AAAAGGTCAG CATCCCCAGA 
GACATCATGT TGGAAGAATT ATCCCATCTC AGTAACCGTG GTGCCAGGCT ATTTAAGATG 
CGTCAAAGAA GATCTGACAA ATACACATTT GAAAATTTCC AGTATCAATC TAGAGCACAA 
ATAAATCACA GTATTGCTAT GCAGAATGGG AAAGTGGATG GAAGTAACTT GGAAGGTGGT 
TCGCAGCAAG CCCCCTTGAC TCCTCCCAAC ACCCCAGATC CACGAAGCCC TCCAAATCCA 
GACAACATTG CTCCAGGATA TTCTGGACCA CTGAAGGAAA TTCCTCCTGA AAAATTCAAC 
ACCACAGCTG TCCCTAAGTA CTATCAATCT CCCTGGGAAC AAGCCATTAG CAATGATCCG 
GAGCTTTTAG AGGCTTTATA TCCTAAACTT TTCAAGCCTG AAGGAAAGGC AGAACTGCCT 
GATTACAGGA GCTTTAACAG GGTTGCCACA CCATTTGGAG GTTTTGAAAA AGCATCAAGA 
ATGGTTAAAT TTAAAGTTCC AGATTTTGAG CTACTATTGC TAACAGATCC CAGGTTTATG 
TCCTTTGTCA ATCCCCTTTC TGGCAGACGG TCCTTTAATA GGACTCCTAA GGGATGGATA 
TCTGAGAATA TTCCTATAGT GATAACAACC GAACCTACAG ATGATACCAC TGTACCAGAA 
TCAGAAGACC TATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MYOZ2 ( XM_006714234.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_006714297.1 Homo sapiens myozenin 2 (MYOZ2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu38965
Clone ID Related Accession (Same CDS sequence)	XM_006714234.3 , XM_006714234.4
Accession Version	XM_006714234.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 588bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	myozenin-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006714234.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTATCAC ATAATACTAT GATGAAGCAG AGAAAACAGC AAGCAACAGC CATCATGAAG 
GAAGTCCATG GAAATGATGT TGATGGCATG GACCTGGGCA AAAAGGTCAG CATCCCCAGA 
GACATCATGT TGGAAGAATT ATCCCATCTC AGTAACCGTG GTGCCAGGCT ATTTAAGATG 
CGTCAAAGAA GATCTGACAA ATACACATTT GAAAATTTCC AGTATCAATC TAGAGCACAA 
ATAAATCACA GTATTGCTAT GCAGAATGGG AAAGTGGATG GAAGTAACTT GGAAGGTGGT 
TCGCAGCAAG CCCCCTTGAC TCCTCCCAAC ACCCCAGATC CACGAAGCCC TCCAAATCCA 
GACAACATTG CTCCAGGATA TTCTGGACCA CTGAAGGAAA TTCCTCCTGA AAAATTCAAC 
ACCACAGCTG TCCCTAAGTA CTATCAATCT CCCTGGGAAC AAGCCATTAG CAATGATCCG 
GAGCTTTTAG AGGCTTTATA TCCTAAACTT TTCAAGCCTG AAGGAAAGGC AGAACTGCCT 
GATTACAGGA GCTTTAACAG GGGTTCAAGA CTTCATTGGA GGAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006714297.1
CDS	182..769
Translation	MLSHNTMMKQRKQQATAIMKEVHGNDVDGMDLGKKVSIPRDIMLEELSHLSNRGARLFKMRQRRSDKYTFENFQYQSRAQINHSIAMQNGKVDGSNLEGGSQQAPLTPPNTPDPRSPPNPDNIAPGYSGPLKEIPPEKFNTTAVPKYYQSPWEQAISNDPELLEALYPKLFKPEGKAELPDYRSFNRGSRLHWRK

Target ORF information:

RefSeq Version	XM_006714234.3
Organism	Homo sapiens(human)
Definition	Homo sapiens myozenin 2 (MYOZ2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006714234.3

ORF Insert Sequence:

ATGCTATCAC ATAATACTAT GATGAAGCAG AGAAAACAGC AAGCAACAGC CATCATGAAG 
GAAGTCCATG GAAATGATGT TGATGGCATG GACCTGGGCA AAAAGGTCAG CATCCCCAGA 
GACATCATGT TGGAAGAATT ATCCCATCTC AGTAACCGTG GTGCCAGGCT ATTTAAGATG 
CGTCAAAGAA GATCTGACAA ATACACATTT GAAAATTTCC AGTATCAATC TAGAGCACAA 
ATAAATCACA GTATTGCTAT GCAGAATGGG AAAGTGGATG GAAGTAACTT GGAAGGTGGT 
TCGCAGCAAG CCCCCTTGAC TCCTCCCAAC ACCCCAGATC CACGAAGCCC TCCAAATCCA 
GACAACATTG CTCCAGGATA TTCTGGACCA CTGAAGGAAA TTCCTCCTGA AAAATTCAAC 
ACCACAGCTG TCCCTAAGTA CTATCAATCT CCCTGGGAAC AAGCCATTAG CAATGATCCG 
GAGCTTTTAG AGGCTTTATA TCCTAAACTT TTCAAGCCTG AAGGAAAGGC AGAACTGCCT 
GATTACAGGA GCTTTAACAG GGGTTCAAGA CTTCATTGGA GGAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MYOZ2 ( XM_006714234.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_006714297.1 Homo sapiens myozenin 2 (MYOZ2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu38965
Clone ID Related Accession (Same CDS sequence)	XM_006714234.3 , XM_006714234.4
Accession Version	XM_006714234.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 588bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	myozenin-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_006714234.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTATCAC ATAATACTAT GATGAAGCAG AGAAAACAGC AAGCAACAGC CATCATGAAG 
GAAGTCCATG GAAATGATGT TGATGGCATG GACCTGGGCA AAAAGGTCAG CATCCCCAGA 
GACATCATGT TGGAAGAATT ATCCCATCTC AGTAACCGTG GTGCCAGGCT ATTTAAGATG 
CGTCAAAGAA GATCTGACAA ATACACATTT GAAAATTTCC AGTATCAATC TAGAGCACAA 
ATAAATCACA GTATTGCTAT GCAGAATGGG AAAGTGGATG GAAGTAACTT GGAAGGTGGT 
TCGCAGCAAG CCCCCTTGAC TCCTCCCAAC ACCCCAGATC CACGAAGCCC TCCAAATCCA 
GACAACATTG CTCCAGGATA TTCTGGACCA CTGAAGGAAA TTCCTCCTGA AAAATTCAAC 
ACCACAGCTG TCCCTAAGTA CTATCAATCT CCCTGGGAAC AAGCCATTAG CAATGATCCG 
GAGCTTTTAG AGGCTTTATA TCCTAAACTT TTCAAGCCTG AAGGAAAGGC AGAACTGCCT 
GATTACAGGA GCTTTAACAG GGGTTCAAGA CTTCATTGGA GGAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006714297.1
CDS	166..753
Translation	MLSHNTMMKQRKQQATAIMKEVHGNDVDGMDLGKKVSIPRDIMLEELSHLSNRGARLFKMRQRRSDKYTFENFQYQSRAQINHSIAMQNGKVDGSNLEGGSQQAPLTPPNTPDPRSPPNPDNIAPGYSGPLKEIPPEKFNTTAVPKYYQSPWEQAISNDPELLEALYPKLFKPEGKAELPDYRSFNRGSRLHWRK

Target ORF information:

RefSeq Version	XM_006714234.4
Organism	Homo sapiens(human)
Definition	Homo sapiens myozenin 2 (MYOZ2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006714234.4

ORF Insert Sequence:

ATGCTATCAC ATAATACTAT GATGAAGCAG AGAAAACAGC AAGCAACAGC CATCATGAAG 
GAAGTCCATG GAAATGATGT TGATGGCATG GACCTGGGCA AAAAGGTCAG CATCCCCAGA 
GACATCATGT TGGAAGAATT ATCCCATCTC AGTAACCGTG GTGCCAGGCT ATTTAAGATG 
CGTCAAAGAA GATCTGACAA ATACACATTT GAAAATTTCC AGTATCAATC TAGAGCACAA 
ATAAATCACA GTATTGCTAT GCAGAATGGG AAAGTGGATG GAAGTAACTT GGAAGGTGGT 
TCGCAGCAAG CCCCCTTGAC TCCTCCCAAC ACCCCAGATC CACGAAGCCC TCCAAATCCA 
GACAACATTG CTCCAGGATA TTCTGGACCA CTGAAGGAAA TTCCTCCTGA AAAATTCAAC 
ACCACAGCTG TCCCTAAGTA CTATCAATCT CCCTGGGAAC AAGCCATTAG CAATGATCCG 
GAGCTTTTAG AGGCTTTATA TCCTAAACTT TTCAAGCCTG AAGGAAAGGC AGAACTGCCT 
GATTACAGGA GCTTTAACAG GGGTTCAAGA CTTCATTGGA GGAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetic anticipation in a special form of hypertrophic cardiomyopathy with sudden cardiac death in a family with 74 members across 5 generations.
Medicine96(11)e6249(2017 Mar)
Guo X,Fan C,Wang Y,Wang M,Cai C,Yang Y,Zhao S,Duan F,Li Y

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Cell164(4)805-17(2016 Feb)
Yang X,Coulombe-Huntington J,Kang S,Sheynkman GM,Hao T,Richardson A,Sun S,Yang F,Shen YA,Murray RR,Spirohn K,Begg BE,Duran-Frigola M,MacWilliams A,Pevzner SJ,Zhong Q,Trigg SA,Tam S,Ghamsari L,Sahni N,Yi S,Rodriguez MD,Balcha D,Tan G,Costanzo M,Andrews B,Boone C,Zhou XJ,Salehi-Ashtiani K,Charloteaux B,Chen AA,Calderwood MA,Aloy P,Roth FP,Hill DE,Iakoucheva LM,Xia Y,Vidal M

Widespread macromolecular interaction perturbations in human genetic disorders.
Cell161(3)647-660(2015 Apr)
Sahni N,Yi S,Taipale M,Fuxman Bass JI,Coulombe-Huntington J,Yang F,Peng J,Weile J,Karras GI,Wang Y,Kov?cs IA,Kamburov A,Krykbaeva I,Lam MH,Tucker G,Khurana V,Sharma A,Liu YY,Yachie N,Zhong Q,Shen Y,Palagi A,San-Miguel A,Fan C,Balcha D,Dricot A,Jordan DM,Walsh JM,Shah AA,Yang X,Stoyanova AK,Leighton A,Calderwood MA,Jacob Y,Cusick ME,Salehi-Ashtiani K,Whitesell LJ,Sunyaev S,Berger B,Barab?si AL,Charloteaux B,Hill DE,Hao T,Roth FP,Xia Y,Walhout AJM,Lindquist S,Vidal M

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MYOZ2 cDNA ORF clone, Homo sapiens(human)

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Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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