CYB5R1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CYB5R1
Entrez Gene ID	51706
Full Name	cytochrome b5 reductase 1
Synonyms	B5R.1,B5R1,B5R2,NQO3A2,humb5R2
General protein information	Preferred Names cytochrome b5 reductase 1 Names NADH-cytochrome b5 reductase 1 NAD(P)H:quinone oxidoreductase type 3, polypeptide A2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q32.1
Disorder MIM:	608341

mRNA and Protein(s)

mRNA	Protein	Name
NM_016243.2	NP_057327.2	NADH-cytochrome b5 reductase 1
NM_016243.3	NP_057327.2	NADH-cytochrome b5 reductase 1

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	LOC100488016	XP_002939683.2
Homo sapiens (human)	CYB5R1	NP_057327.2
Bos taurus (cattle)	CYB5R1	NP_001029690.1
Mus musculus (house mouse)	Cyb5r1	NP_082333.1
	CYB5R1	XP_001105252.1
Rattus norvegicus (Norway rat)	Cyb5r1	NP_001013144.1
Magnaporthe oryzae (rice blast fungus)	MGG_14956	XP_003720314.1
Pan troglodytes (chimpanzee)	LOC740001	XP_001141761.2
Danio rerio (zebrafish)	cyb5r1	NP_956483.1
Neurospora crassa	NCU08060	XP_965191.1

Gene Ontology
Bibliography

Related articles in PubMed

CYB5R1 links epithelial-mesenchymal transition and poor prognosis in colorectal cancer.
Woischke C, Blaj C, Schmidt EM, Lamprecht S, Engel J, Hermeking H, Kirchner T, Horst D
Oncotarget7(21)31350-60(2016 May)

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.
Hasson SA, Kane LA, Yamano K, Huang CH, Sliter DA, Buehler E, Wang C, Heman-Ackah SM, Hessa T, Guha R, Martin SE, Youle RJ
Nature504(7479)291-5(2013 Dec)

Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes.
Zhao X, Le?n IR, Bak S, Mogensen M, Wrzesinski K, H?jlund K, Jensen ON
Molecular & cellular proteomics : MCP10(1)M110.000299(2011 Jan)

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S,
Diabetes care33(10)2250-3(2010 Oct)

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that cytochrome b5 reductase 1 (CYB5R1) gene expression is strongly linked to epithelial-mesenchymal transition (EMT) in colon cancer.
Title: CYB5R1 links epithelial-mesenchymal transition and poor prognosis in colorectal cancer.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

The following CYB5R1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CYB5R1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02293	NM_016243.3 Latest version!	Homo sapiens cytochrome b5 reductase 1 (CYB5R1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu02293	NM_016243.2	Homo sapiens cytochrome b5 reductase 1 (CYB5R1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CYB5R1 ( NM_016243.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_057327.2 Homo sapiens cytochrome b5 reductase 1 (CYB5R1), mRNA.

Price & Availability↑

CloneID	OHu02293
Clone ID Related Accession (Same CDS sequence)	NM_016243.2 , NM_016243.3
Accession Version	NM_016243.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 918bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-31
Organism	Homo sapiens(human)
Product	NADH-cytochrome b5 reductase 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY359026.1 and BC018732.1. On Jul 1, 2004 this sequence version replaced NM_016243.1. ##Evidence-Data-START## Transcript exon combination :: AY359026.1, SRR1163657.463880.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGGGGATCC AGACGAGCCC CGTCCTGCTG GCCTCCCTGG GGGTGGGGCT GGTCACTCTG 
CTCGGCCTGG CTGTGGGCTC CTACTTGGTT CGGAGGTCCC GCCGGCCTCA GGTCACTCTC 
CTGGACCCCA ATGAAAAGTA CCTGCTACGA CTGCTAGACA AGACGACTGT GAGCCACAAC 
ACCAAGAGGT TCCGCTTTGC CCTGCCCACC GCCCACCACA CTCTGGGGCT GCCTGTGGGC 
AAACATATCT ACCTCTCCAC CCGAATTGAT GGCAGCCTGG TCATCAGGCC ATACACTCCT 
GTCACCAGTG ATGAGGATCA AGGCTATGTG GATCTTGTCA TCAAGGTCTA CCTGAAGGGT 
GTGCACCCCA AATTTCCTGA GGGAGGGAAG ATGTCTCAGT ACCTGGATAG CCTGAAGGTT 
GGGGATGTGG TGGAGTTTCG GGGGCCAAGC GGGTTGCTCA CTTACACTGG AAAAGGGCAT 
TTTAACATTC AGCCCAACAA GAAATCTCCA CCAGAACCCC GAGTGGCGAA GAAACTGGGA 
ATGATTGCCG GCGGGACAGG AATCACCCCA ATGCTACAGC TGATCCGGGC CATCCTGAAA 
GTCCCTGAAG ATCCAACCCA GTGCTTTCTG CTTTTTGCCA ACCAGACAGA AAAGGATATC 
ATCTTGCGGG AGGACTTAGA GGAACTGCAG GCCCGCTATC CCAATCGCTT TAAGCTCTGG 
TTCACTCTGG ATCATCCCCC AAAAGATTGG GCCTACAGCA AGGGCTTTGT GACTGCCGAC 
ATGATCCGGG AACACCTGCC CGCTCCAGGG GATGATGTGC TGGTACTGCT TTGTGGGCCA 
CCCCCAATGG TGCAGCTGGC CTGCCATCCC AACTTGGACA AACTGGGCTA CTCACAAAAG 
ATGCGATTCA CCTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057327.2
CDS	72..989
Translation	MGIQTSPVLLASLGVGLVTLLGLAVGSYLVRRSRRPQVTLLDPNEKYLLRLLDKTTVSHNTKRFRFALPTAHHTLGLPVGKHIYLSTRIDGSLVIRPYTPVTSDEDQGYVDLVIKVYLKGVHPKFPEGGKMSQYLDSLKVGDVVEFRGPSGLLTYTGKGHFNIQPNKKSPPEPRVAKKLGMIAGGTGITPMLQLIRAILKVPEDPTQCFLLFANQTEKDIILREDLEELQARYPNRFKLWFTLDHPPKDWAYSKGFVTADMIREHLPAPGDDVLVLLCGPPPMVQLACHPNLDKLGYSQKMRFTY

Target ORF information:

RefSeq Version	NM_016243.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome b5 reductase 1 (CYB5R1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016243.2

ORF Insert Sequence:

ATGGGGATCC AGACGAGCCC CGTCCTGCTG GCCTCCCTGG GGGTGGGGCT GGTCACTCTG 
CTCGGCCTGG CTGTGGGCTC CTACTTGGTT CGGAGGTCCC GCCGGCCTCA GGTCACTCTC 
CTGGACCCCA ATGAAAAGTA CCTGCTACGA CTGCTAGACA AGACGACTGT GAGCCACAAC 
ACCAAGAGGT TCCGCTTTGC CCTGCCCACC GCCCACCACA CTCTGGGGCT GCCTGTGGGC 
AAACATATCT ACCTCTCCAC CCGAATTGAT GGCAGCCTGG TCATCAGGCC ATACACTCCT 
GTCACCAGTG ATGAGGATCA AGGCTATGTG GATCTTGTCA TCAAGGTCTA CCTGAAGGGT 
GTGCACCCCA AATTTCCTGA GGGAGGGAAG ATGTCTCAGT ACCTGGATAG CCTGAAGGTT 
GGGGATGTGG TGGAGTTTCG GGGGCCAAGC GGGTTGCTCA CTTACACTGG AAAAGGGCAT 
TTTAACATTC AGCCCAACAA GAAATCTCCA CCAGAACCCC GAGTGGCGAA GAAACTGGGA 
ATGATTGCCG GCGGGACAGG AATCACCCCA ATGCTACAGC TGATCCGGGC CATCCTGAAA 
GTCCCTGAAG ATCCAACCCA GTGCTTTCTG CTTTTTGCCA ACCAGACAGA AAAGGATATC 
ATCTTGCGGG AGGACTTAGA GGAACTGCAG GCCCGCTATC CCAATCGCTT TAAGCTCTGG 
TTCACTCTGG ATCATCCCCC AAAAGATTGG GCCTACAGCA AGGGCTTTGT GACTGCCGAC 
ATGATCCGGG AACACCTGCC CGCTCCAGGG GATGATGTGC TGGTACTGCT TTGTGGGCCA 
CCCCCAATGG TGCAGCTGGC CTGCCATCCC AACTTGGACA AACTGGGCTA CTCACAAAAG 
ATGCGATTCA CCTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CYB5R1 ( NM_016243.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057327.2 Homo sapiens cytochrome b5 reductase 1 (CYB5R1), mRNA.

Price & Availability↑

CloneID	OHu02293
Clone ID Related Accession (Same CDS sequence)	NM_016243.2 , NM_016243.3
Accession Version	NM_016243.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 918bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	NADH-cytochrome b5 reductase 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY359026.1 and BC018732.1. On Nov 22, 2018 this sequence version replaced NM_016243.2. ##Evidence-Data-START## Transcript exon combination :: AK223416.1, SRR3476690.63487.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000367249.9/ ENSP00000356218.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGGATCC AGACGAGCCC CGTCCTGCTG GCCTCCCTGG GGGTGGGGCT GGTCACTCTG 
CTCGGCCTGG CTGTGGGCTC CTACTTGGTT CGGAGGTCCC GCCGGCCTCA GGTCACTCTC 
CTGGACCCCA ATGAAAAGTA CCTGCTACGA CTGCTAGACA AGACGACTGT GAGCCACAAC 
ACCAAGAGGT TCCGCTTTGC CCTGCCCACC GCCCACCACA CTCTGGGGCT GCCTGTGGGC 
AAACATATCT ACCTCTCCAC CCGAATTGAT GGCAGCCTGG TCATCAGGCC ATACACTCCT 
GTCACCAGTG ATGAGGATCA AGGCTATGTG GATCTTGTCA TCAAGGTCTA CCTGAAGGGT 
GTGCACCCCA AATTTCCTGA GGGAGGGAAG ATGTCTCAGT ACCTGGATAG CCTGAAGGTT 
GGGGATGTGG TGGAGTTTCG GGGGCCAAGC GGGTTGCTCA CTTACACTGG AAAAGGGCAT 
TTTAACATTC AGCCCAACAA GAAATCTCCA CCAGAACCCC GAGTGGCGAA GAAACTGGGA 
ATGATTGCCG GCGGGACAGG AATCACCCCA ATGCTACAGC TGATCCGGGC CATCCTGAAA 
GTCCCTGAAG ATCCAACCCA GTGCTTTCTG CTTTTTGCCA ACCAGACAGA AAAGGATATC 
ATCTTGCGGG AGGACTTAGA GGAACTGCAG GCCCGCTATC CCAATCGCTT TAAGCTCTGG 
TTCACTCTGG ATCATCCCCC AAAAGATTGG GCCTACAGCA AGGGCTTTGT GACTGCCGAC 
ATGATCCGGG AACACCTGCC CGCTCCAGGG GATGATGTGC TGGTACTGCT TTGTGGGCCA 
CCCCCAATGG TGCAGCTGGC CTGCCATCCC AACTTGGACA AACTGGGCTA CTCACAAAAG 
ATGCGATTCA CCTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057327.2
CDS	53..970
Translation	MGIQTSPVLLASLGVGLVTLLGLAVGSYLVRRSRRPQVTLLDPNEKYLLRLLDKTTVSHNTKRFRFALPTAHHTLGLPVGKHIYLSTRIDGSLVIRPYTPVTSDEDQGYVDLVIKVYLKGVHPKFPEGGKMSQYLDSLKVGDVVEFRGPSGLLTYTGKGHFNIQPNKKSPPEPRVAKKLGMIAGGTGITPMLQLIRAILKVPEDPTQCFLLFANQTEKDIILREDLEELQARYPNRFKLWFTLDHPPKDWAYSKGFVTADMIREHLPAPGDDVLVLLCGPPPMVQLACHPNLDKLGYSQKMRFTY

Target ORF information:

RefSeq Version	NM_016243.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome b5 reductase 1 (CYB5R1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016243.3

ORF Insert Sequence:

ATGGGGATCC AGACGAGCCC CGTCCTGCTG GCCTCCCTGG GGGTGGGGCT GGTCACTCTG 
CTCGGCCTGG CTGTGGGCTC CTACTTGGTT CGGAGGTCCC GCCGGCCTCA GGTCACTCTC 
CTGGACCCCA ATGAAAAGTA CCTGCTACGA CTGCTAGACA AGACGACTGT GAGCCACAAC 
ACCAAGAGGT TCCGCTTTGC CCTGCCCACC GCCCACCACA CTCTGGGGCT GCCTGTGGGC 
AAACATATCT ACCTCTCCAC CCGAATTGAT GGCAGCCTGG TCATCAGGCC ATACACTCCT 
GTCACCAGTG ATGAGGATCA AGGCTATGTG GATCTTGTCA TCAAGGTCTA CCTGAAGGGT 
GTGCACCCCA AATTTCCTGA GGGAGGGAAG ATGTCTCAGT ACCTGGATAG CCTGAAGGTT 
GGGGATGTGG TGGAGTTTCG GGGGCCAAGC GGGTTGCTCA CTTACACTGG AAAAGGGCAT 
TTTAACATTC AGCCCAACAA GAAATCTCCA CCAGAACCCC GAGTGGCGAA GAAACTGGGA 
ATGATTGCCG GCGGGACAGG AATCACCCCA ATGCTACAGC TGATCCGGGC CATCCTGAAA 
GTCCCTGAAG ATCCAACCCA GTGCTTTCTG CTTTTTGCCA ACCAGACAGA AAAGGATATC 
ATCTTGCGGG AGGACTTAGA GGAACTGCAG GCCCGCTATC CCAATCGCTT TAAGCTCTGG 
TTCACTCTGG ATCATCCCCC AAAAGATTGG GCCTACAGCA AGGGCTTTGT GACTGCCGAC 
ATGATCCGGG AACACCTGCC CGCTCCAGGG GATGATGTGC TGGTACTGCT TTGTGGGCCA 
CCCCCAATGG TGCAGCTGGC CTGCCATCCC AACTTGGACA AACTGGGCTA CTCACAAAAG 
ATGCGATTCA CCTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CYB5R1 links epithelial-mesenchymal transition and poor prognosis in colorectal cancer.
Oncotarget7(21)31350-60(2016 May)
Woischke C,Blaj C,Schmidt EM,Lamprecht S,Engel J,Hermeking H,Kirchner T,Horst D

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.
Nature504(7479)291-5(2013 Dec)
Hasson SA,Kane LA,Yamano K,Huang CH,Sliter DA,Buehler E,Wang C,Heman-Ackah SM,Hessa T,Guha R,Martin SE,Youle RJ

Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes.
Molecular & cellular proteomics : MCP10(1)M110.000299(2011 Jan)
Zhao X,Le?n IR,Bak S,Mogensen M,Wrzesinski K,H?jlund K,Jensen ON

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Diabetes care33(10)2250-3(2010 Oct)
Bailey SD,Xie C,Do R,Montpetit A,Diaz R,Mohan V,Keavney B,Yusuf S,Gerstein HC,Engert JC,Anand S,

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ

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CYB5R1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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