HECA cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HECA
Entrez Gene ID	51696
Full Name	hdc homolog, cell cycle regulator
Synonyms	HDC,HDCL,HHDC,dJ225E12.1
General protein information	Preferred Names hdc homolog, cell cycle regulator Names headcase protein homolog headcase homolog
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6q24.1
Summary	This gene encodes the homolog of the Drosophila headcase protein, a highly basic, cytoplasmic protein that regulates the re-entry of imaginal cells into the mitotic cycle during adult morphogenesis. In Drosophila, the encoded protein also inhibits terminal branching of neighboring cells during tracheal development. [provided by RefSeq, Jul 2008].
Disorder MIM:	607977

mRNA and Protein(s)

mRNA	Protein	Name
NM_016217.3	NP_057301.1	headcase protein homolog
NM_016217.2	NP_057301.1	headcase protein homolog

Pathways from BioSystems

Homologies

Bos taurus (cattle)	HECA	XP_002690328.3
Gallus gallus (chicken)	HECA	XP_419714.4
Mus musculus (house mouse)	Heca	NP_001028604.1
Xenopus tropicalis (tropical clawed frog)	heca	NP_001090826.1
Pan troglodytes (chimpanzee)	HECA	XP_527517.2
Rattus norvegicus (Norway rat)	Heca	NP_001100984.1
Danio rerio (zebrafish)	heca	NP_001038591.1
Homo sapiens (human)	HECA	NP_057301.1
	HECA	XP_002808444.1
Canis lupus familiaris (dog)	HECA	XP_533428.2

Gene Ontology
Bibliography

Related articles in PubMed

The Human Homolog of Drosophila Headcase Acts as a Tumor Suppressor through Its Blocking Effect on the Cell Cycle in Hepatocellular Carcinoma.
Wang J, Gong L, Zhu SJ, Zhu Q, Yao L, Han XJ, Zhang JR, Li YH, Zhang W
PloS one10(9)e0137579(2015)

The human HECA interacts with cyclins and CDKs to antagonize Wnt-mediated proliferation and chemoresistance of head and neck cancer cells.
Dowejko A, Bauer R, Bauer K, M?ller-Richter UD, Reichert TE
Experimental cell research318(5)489-99(2012 Mar)

Defining the membrane proteome of NK cells.
Ghosh D, Lippert D, Krokhin O, Cortens JP, Wilkins JA
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)

The human homolog of the Drosophila headcase protein slows down cell division of head and neck cancer cells.
Dowejko A, Bauer RJ, M?ller-Richter UD, Reichert TE
Carcinogenesis30(10)1678-85(2009 Oct)

Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus R, van Heel DA, Wijmenga C
Gut58(8)1078-83(2009 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The Human Homolog of Drosophila Headcase Acts as a Tumor Suppressor through Its Blocking Effect on the Cell Cycle in Hepatocellular Carcinoma
Title: The Human Homolog of Drosophila Headcase Acts as a Tumor Suppressor through Its Blocking Effect on the Cell Cycle in Hepatocellular Carcinoma.

HECA expression is markedly decreased in oral squamous cell carcinoma (OSCC) compared to controls and is associated with decreased sensitivity to cisplatin in OSCC cell lines
Title: The human HECA interacts with cyclins and CDKs to antagonize Wnt-mediated proliferation and chemoresistance of head and neck cancer cells.

Human HECA slows down cell division of oral squamous cell carcinoma cells and may therefore act as a tumor suppressor in head and neck cancer.
Title: The human homolog of the Drosophila headcase protein slows down cell division of head and neck cancer cells.

Observational study of gene-disease association. (HuGE Navigator)
Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.

Data show that HECA may be an early-stage classifier of colorectal cancer that can discriminate between late- and early-stage disease.
Title: A homologue of the Drosophila headcase protein is a novel tumor marker for early-stage colorectal cancer.

The following HECA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HECA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30811	NM_016217.3 Latest version!	Homo sapiens hdc homolog, cell cycle regulator (HECA), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu30811	NM_016217.2	Homo sapiens hdc homolog, cell cycle regulator (HECA), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HECA ( NM_016217.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057301.1 Homo sapiens hdc homolog, cell cycle regulator (HECA), mRNA.

Price & Availability↑

CloneID	OHu30811
Clone ID Related Accession (Same CDS sequence)	NM_016217.3 , NM_016217.2
Accession Version	NM_016217.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1632bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-27
Organism	Homo sapiens(human)
Product	headcase protein homolog
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL031772.6, BC070068.1 and AB033492.1. On Nov 22, 2018 this sequence version replaced NM_016217.2. ##Evidence-Data-START## Transcript exon combination :: BC070068.1, SRR1803614.7220.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000367658.3/ ENSP00000356630.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCCAACC CCAAAAACAG CAAAGGCGGC CGCAAAAACA AGCGCGCCAA CAGCAGCGGC 
GACGAGCAGG AAAATGGAGC CGGGGCCCTG GCAGCGGCGG GCGCGGCGGG AGCGGCGGCC 
GGGGGGGCCC TGGCGGCGGC GGCCGGTTGC GGGGCGGCGG CGGCGGGCGC GCCGGGCGCC 
GGAGGCGCGG CGGGCGCCGG AGGCGCGGGG ACTGGCGCCG CGAACGCTGC GGCCGCCGCG 
GGGGCTGCGG CCGCGGGCGA TGCCAAAAAC GAAGCCCCAT GTGCCACTCC CCTGATCTGC 
AGCTTCGGTA GGCCGGTGGA CCTGGAGAAG GACGACTACC AGAAGGTGGT GTGCAACAAC 
GAGCACTGCC CCTGCAGCAC CTGGATGCAC CTGCAGTGCT TCTACGAGTG GGAGAGCAGC 
ATCCTCGTCC AGTTCAACTG CATCGGCCGC GCGCGCAGCT GGAACGAGAA GCAATGCCGC 
CAGAACATGT GGACAAAGAA GGGCTACGAC CTGGCCTTCC GCTTCTGCTC TTGCCGCTGT 
GGCCAGGGCC ACTTGAAGAA GGACACAGAC TGGTATCAGG TGAAGCGGAT GCAGGACGAG 
AAAAAGAAGA AGTCTGGCTC CGAGAAGAAC ACAGGGAGGC CTCCTGGTGA GGCGGCGGAG 
GAGGCAAAAA AGTGCAGGCC CCCAAATAAG CCCCAGAAAG GCCCAAGCCA CGACCTCCCC 
CGCCGGCATT CCATGGACCG GCAGAACTCC CAGGAGAAGG CAGTGGGTGC CGCAGCCTAC 
GGTGCCCGTT CCCCCGGTGG CTCCCCGGGC CAGTCCCCAC CCACGGGCTA CTCCATCCTC 
TCTCCTGCCC ACTTCAGCGG CCCCCGCTCC TCCAGATACC TCGGGGAGTT CTTAAAGAAC 
GCCATCCATC TGGAGCCTCA CAAGAAGGCC ATGGCTGGGG GCCATGTGTT CAGAAATGCC 
CACTTTGATT ACAGCCCTGC GGGGTTGGCA GTTCACAGGG GGGGACACTT CGACACCCCC 
GTGCAGTTCC TTCGGCGGCT GGACCTCTCC GAACTCCTCA CTCACATCCC CAGGCATAAG 
CTGAACACTT TCCACGTGCG CATGGAAGAC GATGCCCAAG TGGGCCAGGG GGAAGACTTG 
CGGAAGTTCA TTCTGGCCGC GCTCAGTGCC AGCCACAGAA ACGTGGTAAA CTGTGCCCTG 
TGCCACCGGG CGCTCCCGGT GTTCGAACAG TTCCCACTGG TGGATGGAAC TTTGTTCCTA 
AGCCCGTCGA GACATGATGA GATCGAATAT GATGTTCCTT GTCACCTTCA AGGGAGACTC 
ATGCATCTGT ATGCCGTGTG CGTGGACTGC CTGGAAGGGG TTCACAAGAT CATCTGCATC 
AAGTGTAAGT CACGGTGGGA TGGCAGCTGG CACCAGCTGG GCACTATGTA CACCTACGAC 
ATCCTGGCTG CCTCTCCATG TTGTCAGGCC CGCCTGAACT GTAAGCACTG TGGGAAGCCG 
GTGATCGACG TGAGGATCGG GATGCAGTAC TTCTCCGAAT ATAGCAACGT CCAGCAGTGT 
CCACACTGTG GGAACCTGGA CTACCACTTC GTGAAGCCAT TTTCCTCCTT CAAAGTTCTC 
GAAGCTTATT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057301.1
CDS	318..1949
Translation	MPNPKNSKGGRKNKRANSSGDEQENGAGALAAAGAAGAAAGGALAAAAGCGAAAAGAPGAGGAAGAGGAGTGAANAAAAAGAAAAGDAKNEAPCATPLICSFGRPVDLEKDDYQKVVCNNEHCPCSTWMHLQCFYEWESSILVQFNCIGRARSWNEKQCRQNMWTKKGYDLAFRFCSCRCGQGHLKKDTDWYQVKRMQDEKKKKSGSEKNTGRPPGEAAEEAKKCRPPNKPQKGPSHDLPRRHSMDRQNSQEKAVGAAAYGARSPGGSPGQSPPTGYSILSPAHFSGPRSSRYLGEFLKNAIHLEPHKKAMAGGHVFRNAHFDYSPAGLAVHRGGHFDTPVQFLRRLDLSELLTHIPRHKLNTFHVRMEDDAQVGQGEDLRKFILAALSASHRNVVNCALCHRALPVFEQFPLVDGTLFLSPSRHDEIEYDVPCHLQGRLMHLYAVCVDCLEGVHKIICIKCKSRWDGSWHQLGTMYTYDILAASPCCQARLNCKHCGKPVIDVRIGMQYFSEYSNVQQCPHCGNLDYHFVKPFSSFKVLEAY

Target ORF information:

RefSeq Version	NM_016217.3
Organism	Homo sapiens(human)
Definition	Homo sapiens hdc homolog, cell cycle regulator (HECA), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016217.3

ORF Insert Sequence:

ATGCCCAACC CCAAAAACAG CAAAGGCGGC CGCAAAAACA AGCGCGCCAA CAGCAGCGGC 
GACGAGCAGG AAAATGGAGC CGGGGCCCTG GCAGCGGCGG GCGCGGCGGG AGCGGCGGCC 
GGGGGGGCCC TGGCGGCGGC GGCCGGTTGC GGGGCGGCGG CGGCGGGCGC GCCGGGCGCC 
GGAGGCGCGG CGGGCGCCGG AGGCGCGGGG ACTGGCGCCG CGAACGCTGC GGCCGCCGCG 
GGGGCTGCGG CCGCGGGCGA TGCCAAAAAC GAAGCCCCAT GTGCCACTCC CCTGATCTGC 
AGCTTCGGTA GGCCGGTGGA CCTGGAGAAG GACGACTACC AGAAGGTGGT GTGCAACAAC 
GAGCACTGCC CCTGCAGCAC CTGGATGCAC CTGCAGTGCT TCTACGAGTG GGAGAGCAGC 
ATCCTCGTCC AGTTCAACTG CATCGGCCGC GCGCGCAGCT GGAACGAGAA GCAATGCCGC 
CAGAACATGT GGACAAAGAA GGGCTACGAC CTGGCCTTCC GCTTCTGCTC TTGCCGCTGT 
GGCCAGGGCC ACTTGAAGAA GGACACAGAC TGGTATCAGG TGAAGCGGAT GCAGGACGAG 
AAAAAGAAGA AGTCTGGCTC CGAGAAGAAC ACAGGGAGGC CTCCTGGTGA GGCGGCGGAG 
GAGGCAAAAA AGTGCAGGCC CCCAAATAAG CCCCAGAAAG GCCCAAGCCA CGACCTCCCC 
CGCCGGCATT CCATGGACCG GCAGAACTCC CAGGAGAAGG CAGTGGGTGC CGCAGCCTAC 
GGTGCCCGTT CCCCCGGTGG CTCCCCGGGC CAGTCCCCAC CCACGGGCTA CTCCATCCTC 
TCTCCTGCCC ACTTCAGCGG CCCCCGCTCC TCCAGATACC TCGGGGAGTT CTTAAAGAAC 
GCCATCCATC TGGAGCCTCA CAAGAAGGCC ATGGCTGGGG GCCATGTGTT CAGAAATGCC 
CACTTTGATT ACAGCCCTGC GGGGTTGGCA GTTCACAGGG GGGGACACTT CGACACCCCC 
GTGCAGTTCC TTCGGCGGCT GGACCTCTCC GAACTCCTCA CTCACATCCC CAGGCATAAG 
CTGAACACTT TCCACGTGCG CATGGAAGAC GATGCCCAAG TGGGCCAGGG GGAAGACTTG 
CGGAAGTTCA TTCTGGCCGC GCTCAGTGCC AGCCACAGAA ACGTGGTAAA CTGTGCCCTG 
TGCCACCGGG CGCTCCCGGT GTTCGAACAG TTCCCACTGG TGGATGGAAC TTTGTTCCTA 
AGCCCGTCGA GACATGATGA GATCGAATAT GATGTTCCTT GTCACCTTCA AGGGAGACTC 
ATGCATCTGT ATGCCGTGTG CGTGGACTGC CTGGAAGGGG TTCACAAGAT CATCTGCATC 
AAGTGTAAGT CACGGTGGGA TGGCAGCTGG CACCAGCTGG GCACTATGTA CACCTACGAC 
ATCCTGGCTG CCTCTCCATG TTGTCAGGCC CGCCTGAACT GTAAGCACTG TGGGAAGCCG 
GTGATCGACG TGAGGATCGG GATGCAGTAC TTCTCCGAAT ATAGCAACGT CCAGCAGTGT 
CCACACTGTG GGAACCTGGA CTACCACTTC GTGAAGCCAT TTTCCTCCTT CAAAGTTCTC 
GAAGCTTATT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HECA ( NM_016217.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_057301.1 Homo sapiens hdc homolog, cell cycle regulator (HECA), mRNA.

Price & Availability↑

CloneID	OHu30811
Clone ID Related Accession (Same CDS sequence)	NM_016217.3 , NM_016217.2
Accession Version	NM_016217.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1632bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	headcase protein homolog
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC070068.1, AB033492.1 and AL031772.6. On Jun 3, 2005 this sequence version replaced NM_016217.1. ##Evidence-Data-START## Transcript exon combination :: AB033492.1, BC070068.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCAACC CCAAAAACAG CAAAGGCGGC CGCAAAAACA AGCGCGCCAA CAGCAGCGGC 
GACGAGCAGG AAAATGGAGC CGGGGCCCTG GCAGCGGCGG GCGCGGCGGG AGCGGCGGCC 
GGGGGGGCCC TGGCGGCGGC GGCCGGTTGC GGGGCGGCGG CGGCGGGCGC GCCGGGCGCC 
GGAGGCGCGG CGGGCGCCGG AGGCGCGGGG ACTGGCGCCG CGAACGCTGC GGCCGCCGCG 
GGGGCTGCGG CCGCGGGCGA TGCCAAAAAC GAAGCCCCAT GTGCCACTCC CCTGATCTGC 
AGCTTCGGTA GGCCGGTGGA CCTGGAGAAG GACGACTACC AGAAGGTGGT GTGCAACAAC 
GAGCACTGCC CCTGCAGCAC CTGGATGCAC CTGCAGTGCT TCTACGAGTG GGAGAGCAGC 
ATCCTCGTCC AGTTCAACTG CATCGGCCGC GCGCGCAGCT GGAACGAGAA GCAATGCCGC 
CAGAACATGT GGACAAAGAA GGGCTACGAC CTGGCCTTCC GCTTCTGCTC TTGCCGCTGT 
GGCCAGGGCC ACTTGAAGAA GGACACAGAC TGGTATCAGG TGAAGCGGAT GCAGGACGAG 
AAAAAGAAGA AGTCTGGCTC CGAGAAGAAC ACAGGGAGGC CTCCTGGTGA GGCGGCGGAG 
GAGGCAAAAA AGTGCAGGCC CCCAAATAAG CCCCAGAAAG GCCCAAGCCA CGACCTCCCC 
CGCCGGCATT CCATGGACCG GCAGAACTCC CAGGAGAAGG CAGTGGGTGC CGCAGCCTAC 
GGTGCCCGTT CCCCCGGTGG CTCCCCGGGC CAGTCCCCAC CCACGGGCTA CTCCATCCTC 
TCTCCTGCCC ACTTCAGCGG CCCCCGCTCC TCCAGATACC TCGGGGAGTT CTTAAAGAAC 
GCCATCCATC TGGAGCCTCA CAAGAAGGCC ATGGCTGGGG GCCATGTGTT CAGAAATGCC 
CACTTTGATT ACAGCCCTGC GGGGTTGGCA GTTCACAGGG GGGGACACTT CGACACCCCC 
GTGCAGTTCC TTCGGCGGCT GGACCTCTCC GAACTCCTCA CTCACATCCC CAGGCATAAG 
CTGAACACTT TCCACGTGCG CATGGAAGAC GATGCCCAAG TGGGCCAGGG GGAAGACTTG 
CGGAAGTTCA TTCTGGCCGC GCTCAGTGCC AGCCACAGAA ACGTGGTAAA CTGTGCCCTG 
TGCCACCGGG CGCTCCCGGT GTTCGAACAG TTCCCACTGG TGGATGGAAC TTTGTTCCTA 
AGCCCGTCGA GACATGATGA GATCGAATAT GATGTTCCTT GTCACCTTCA AGGGAGACTC 
ATGCATCTGT ATGCCGTGTG CGTGGACTGC CTGGAAGGGG TTCACAAGAT CATCTGCATC 
AAGTGTAAGT CACGGTGGGA TGGCAGCTGG CACCAGCTGG GCACTATGTA CACCTACGAC 
ATCCTGGCTG CCTCTCCATG TTGTCAGGCC CGCCTGAACT GTAAGCACTG TGGGAAGCCG 
GTGATCGACG TGAGGATCGG GATGCAGTAC TTCTCCGAAT ATAGCAACGT CCAGCAGTGT 
CCACACTGTG GGAACCTGGA CTACCACTTC GTGAAGCCAT TTTCCTCCTT CAAAGTTCTC 
GAAGCTTATT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057301.1
CDS	286..1917
Translation	MPNPKNSKGGRKNKRANSSGDEQENGAGALAAAGAAGAAAGGALAAAAGCGAAAAGAPGAGGAAGAGGAGTGAANAAAAAGAAAAGDAKNEAPCATPLICSFGRPVDLEKDDYQKVVCNNEHCPCSTWMHLQCFYEWESSILVQFNCIGRARSWNEKQCRQNMWTKKGYDLAFRFCSCRCGQGHLKKDTDWYQVKRMQDEKKKKSGSEKNTGRPPGEAAEEAKKCRPPNKPQKGPSHDLPRRHSMDRQNSQEKAVGAAAYGARSPGGSPGQSPPTGYSILSPAHFSGPRSSRYLGEFLKNAIHLEPHKKAMAGGHVFRNAHFDYSPAGLAVHRGGHFDTPVQFLRRLDLSELLTHIPRHKLNTFHVRMEDDAQVGQGEDLRKFILAALSASHRNVVNCALCHRALPVFEQFPLVDGTLFLSPSRHDEIEYDVPCHLQGRLMHLYAVCVDCLEGVHKIICIKCKSRWDGSWHQLGTMYTYDILAASPCCQARLNCKHCGKPVIDVRIGMQYFSEYSNVQQCPHCGNLDYHFVKPFSSFKVLEAY

Target ORF information:

RefSeq Version	NM_016217.2
Organism	Homo sapiens(human)
Definition	Homo sapiens hdc homolog, cell cycle regulator (HECA), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016217.2

ORF Insert Sequence:

ATGCCCAACC CCAAAAACAG CAAAGGCGGC CGCAAAAACA AGCGCGCCAA CAGCAGCGGC 
GACGAGCAGG AAAATGGAGC CGGGGCCCTG GCAGCGGCGG GCGCGGCGGG AGCGGCGGCC 
GGGGGGGCCC TGGCGGCGGC GGCCGGTTGC GGGGCGGCGG CGGCGGGCGC GCCGGGCGCC 
GGAGGCGCGG CGGGCGCCGG AGGCGCGGGG ACTGGCGCCG CGAACGCTGC GGCCGCCGCG 
GGGGCTGCGG CCGCGGGCGA TGCCAAAAAC GAAGCCCCAT GTGCCACTCC CCTGATCTGC 
AGCTTCGGTA GGCCGGTGGA CCTGGAGAAG GACGACTACC AGAAGGTGGT GTGCAACAAC 
GAGCACTGCC CCTGCAGCAC CTGGATGCAC CTGCAGTGCT TCTACGAGTG GGAGAGCAGC 
ATCCTCGTCC AGTTCAACTG CATCGGCCGC GCGCGCAGCT GGAACGAGAA GCAATGCCGC 
CAGAACATGT GGACAAAGAA GGGCTACGAC CTGGCCTTCC GCTTCTGCTC TTGCCGCTGT 
GGCCAGGGCC ACTTGAAGAA GGACACAGAC TGGTATCAGG TGAAGCGGAT GCAGGACGAG 
AAAAAGAAGA AGTCTGGCTC CGAGAAGAAC ACAGGGAGGC CTCCTGGTGA GGCGGCGGAG 
GAGGCAAAAA AGTGCAGGCC CCCAAATAAG CCCCAGAAAG GCCCAAGCCA CGACCTCCCC 
CGCCGGCATT CCATGGACCG GCAGAACTCC CAGGAGAAGG CAGTGGGTGC CGCAGCCTAC 
GGTGCCCGTT CCCCCGGTGG CTCCCCGGGC CAGTCCCCAC CCACGGGCTA CTCCATCCTC 
TCTCCTGCCC ACTTCAGCGG CCCCCGCTCC TCCAGATACC TCGGGGAGTT CTTAAAGAAC 
GCCATCCATC TGGAGCCTCA CAAGAAGGCC ATGGCTGGGG GCCATGTGTT CAGAAATGCC 
CACTTTGATT ACAGCCCTGC GGGGTTGGCA GTTCACAGGG GGGGACACTT CGACACCCCC 
GTGCAGTTCC TTCGGCGGCT GGACCTCTCC GAACTCCTCA CTCACATCCC CAGGCATAAG 
CTGAACACTT TCCACGTGCG CATGGAAGAC GATGCCCAAG TGGGCCAGGG GGAAGACTTG 
CGGAAGTTCA TTCTGGCCGC GCTCAGTGCC AGCCACAGAA ACGTGGTAAA CTGTGCCCTG 
TGCCACCGGG CGCTCCCGGT GTTCGAACAG TTCCCACTGG TGGATGGAAC TTTGTTCCTA 
AGCCCGTCGA GACATGATGA GATCGAATAT GATGTTCCTT GTCACCTTCA AGGGAGACTC 
ATGCATCTGT ATGCCGTGTG CGTGGACTGC CTGGAAGGGG TTCACAAGAT CATCTGCATC 
AAGTGTAAGT CACGGTGGGA TGGCAGCTGG CACCAGCTGG GCACTATGTA CACCTACGAC 
ATCCTGGCTG CCTCTCCATG TTGTCAGGCC CGCCTGAACT GTAAGCACTG TGGGAAGCCG 
GTGATCGACG TGAGGATCGG GATGCAGTAC TTCTCCGAAT ATAGCAACGT CCAGCAGTGT 
CCACACTGTG GGAACCTGGA CTACCACTTC GTGAAGCCAT TTTCCTCCTT CAAAGTTCTC 
GAAGCTTATT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Human Homolog of Drosophila Headcase Acts as a Tumor Suppressor through Its Blocking Effect on the Cell Cycle in Hepatocellular Carcinoma.
PloS one10(9)e0137579(2015)
Wang J,Gong L,Zhu SJ,Zhu Q,Yao L,Han XJ,Zhang JR,Li YH,Zhang W

The human HECA interacts with cyclins and CDKs to antagonize Wnt-mediated proliferation and chemoresistance of head and neck cancer cells.
Experimental cell research318(5)489-99(2012 Mar)
Dowejko A,Bauer R,Bauer K,M?ller-Richter UD,Reichert TE

Defining the membrane proteome of NK cells.
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)
Ghosh D,Lippert D,Krokhin O,Cortens JP,Wilkins JA

The human homolog of the Drosophila headcase protein slows down cell division of head and neck cancer cells.
Carcinogenesis30(10)1678-85(2009 Oct)
Dowejko A,Bauer RJ,M?ller-Richter UD,Reichert TE

Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
Gut58(8)1078-83(2009 Aug)
Trynka G,Zhernakova A,Romanos J,Franke L,Hunt KA,Turner G,Bruinenberg M,Heap GA,Platteel M,Ryan AW,de Kovel C,Holmes GK,Howdle PD,Walters JR,Sanders DS,Mulder CJ,Mearin ML,Verbeek WH,Trimble V,Stevens FM,Kelleher D,Barisani D,Bardella MT,McManus R,van Heel DA,Wijmenga C

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HECA cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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