LSM8 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LSM8
Entrez Gene ID	51691
Full Name	LSM8 homolog, U6 small nuclear RNA associated
Synonyms	NAA38
General protein information	Preferred Names LSM8 homolog, U6 small nuclear RNA associated Names LSM8 homolog, U6 small nuclear RNA associated LSM8 U6 small nuclear RNA associated MAK31-like protein N-alpha-acetyltransferase 38, NatC auxiliary subunit U6 snRNA-associated Sm-like protein LSm8
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q31.31
Summary	This gene encodes a member of the like-Sm family of proteins. The encoded protein consists of a closed barrel shape, made up of five anti-parallel beta strands and an alpha helix. This protein partners with six paralogs to form a heteroheptameric ring which transiently binds U6 small nuclear RNAs and is involved in the general maturation of RNA in the nucleus. [provided by RefSeq, Jan 2010].
Disorder MIM:	607288

mRNA and Protein(s)

mRNA	Protein	Name
NM_016200.5	NP_057284.1	LSM8 homolog, U6 small nuclear RNA associated
NM_016200.4	NP_057284.1	LSM8 homolog, U6 small nuclear RNA associated

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	LSM8	XP_532529.1
Mus musculus (house mouse)	Lsm8	NP_598700.1
Pan troglodytes (chimpanzee)	LSM8	XP_001141412.2
Canis lupus familiaris (dog)	LOC100685900	XP_005631761.1
	LSM8	XP_001097050.2
Rattus norvegicus (Norway rat)	Lsm8	NP_001100055.1
Drosophila melanogaster (fruit fly)	CG2021	NP_647660.1
Caenorhabditis elegans (roundworm)	lsm-8	NP_500964.1
Oryza sativa (rice)	Os05g0594900	NP_001056510.1
Xenopus tropicalis (tropical clawed frog)	lsm8	XP_002935003.2
Bos taurus (cattle)	NAA38	NP_001029912.1
Gallus gallus (chicken)	LSM8	NP_001264284.1
Danio rerio (zebrafish)	lsm8	XP_694374.3
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011837	XP_320680.1
Homo sapiens (human)	LSM8	NP_057284.1
Arabidopsis thaliana (thale cress)	AT1G65700	NP_001031238.1

Gene Ontology
Bibliography

Related articles in PubMed

Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.
Bertram K, Agafonov DE, Dybkov O, Haselbach D, Leelaram MN, Will CL, Urlaub H, Kastner B, L?hrmann R, Stark H
Cell170(4)701-713.e11(2017 Aug)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Molecular architecture of the human U4/U6.U5 tri-snRNP.
Agafonov DE, Kastner B, Dybkov O, Hofele RV, Liu WT, Urlaub H, L?hrmann R, Stark H
Science (New York, N.Y.)351(6280)1416-20(2016 Mar)

Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.
Cobb J, Cule E, Moncrieffe H, Hinks A, Ursu S, Patrick F, Kassoumeri L, Flynn E, Bulatovi? M, Wulffraat N, van Zelst B, de Jonge R, Bohm M, Dolezalova P, Hirani S, Newman S, Whitworth P, Southwood TR, De Iorio M, , , , Wedderburn LR, Thomson W
The pharmacogenomics journal14(4)356-64(2014 Aug)

Nuclear LSm8 affects number of cytoplasmic processing bodies via controlling cellular distribution of Like-Sm proteins.
Novotny I, Podolsk? K, Blaz?kov? M, Val?sek LS, Svoboda P, Stanek D
Molecular biology of the cell23(19)3776-85(2012 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

LSm8 controls nuclear accumulation of all LSm2-7 proteins and the number of cytoplasmic processing bodies.
Title: Nuclear LSm8 affects number of cytoplasmic processing bodies via controlling cellular distribution of Like-Sm proteins.

The following LSM8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LSM8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29972	NM_016200.5 Latest version!	Homo sapiens LSM8 homolog, U6 small nuclear RNA associated (LSM8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu29972	NM_016200.4	Homo sapiens LSM8 homolog, U6 small nuclear RNA associated (LSM8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LSM8 ( NM_016200.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_057284.1 Homo sapiens LSM8 homolog, U6 small nuclear RNA associated (LSM8), mRNA.

Price & Availability↑

CloneID	OHu29972
Clone ID Related Accession (Same CDS sequence)	NM_016200.5 , NM_016200.4
Accession Version	NM_016200.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 291bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	LSM8 homolog, U6 small nuclear RNA associated
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA478457.1 and AC006389.2. On Nov 23, 2018 this sequence version replaced NM_016200.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA247272.1, SRR1803617.184135.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000249299.7/ ENSP00000249299.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACGTCCG CTTTGGAGAA CTACATCAAC CGAACTGTTG CCGTTATTAC ATCAGATGGG 
AGAATGATTG TGGGAACACT GAAAGGTTTT GACCAGACCA TTAATTTGAT TTTGGATGAA 
AGCCATGAAC GAGTATTCAG CTCTTCACAG GGGGTAGAAC AAGTGGTACT AGGATTATAC 
ATTGTAAGAG GTGACAACGT TGCAGTCATT GGAGAAATCG ATGAAGAAAC AGATTCTGCG 
CTTGATTTGG GGAATATTCG AGCAGAACCT TTAAATTCTG TAGCACACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057284.1
CDS	61..351
Translation	MTSALENYINRTVAVITSDGRMIVGTLKGFDQTINLILDESHERVFSSSQGVEQVVLGLYIVRGDNVAVIGEIDEETDSALDLGNIRAEPLNSVAH

Target ORF information:

RefSeq Version	NM_016200.5
Organism	Homo sapiens(human)
Definition	Homo sapiens LSM8 homolog, U6 small nuclear RNA associated (LSM8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016200.5

ORF Insert Sequence:

ATGACGTCCG CTTTGGAGAA CTACATCAAC CGAACTGTTG CCGTTATTAC ATCAGATGGG 
AGAATGATTG TGGGAACACT GAAAGGTTTT GACCAGACCA TTAATTTGAT TTTGGATGAA 
AGCCATGAAC GAGTATTCAG CTCTTCACAG GGGGTAGAAC AAGTGGTACT AGGATTATAC 
ATTGTAAGAG GTGACAACGT TGCAGTCATT GGAGAAATCG ATGAAGAAAC AGATTCTGCG 
CTTGATTTGG GGAATATTCG AGCAGAACCT TTAAATTCTG TAGCACACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LSM8 ( NM_016200.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057284.1 Homo sapiens LSM8 homolog, U6 small nuclear RNA associated (LSM8), mRNA.

Price & Availability↑

CloneID	OHu29972
Clone ID Related Accession (Same CDS sequence)	NM_016200.5 , NM_016200.4
Accession Version	NM_016200.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 291bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	LSM8 homolog, U6 small nuclear RNA associated
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC006389.2 and DA478457.1. On Jan 21, 2010 this sequence version replaced NM_016200.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DB275674.1, SRR1803617.184135.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACGTCCG CTTTGGAGAA CTACATCAAC CGAACTGTTG CCGTTATTAC ATCAGATGGG 
AGAATGATTG TGGGAACACT GAAAGGTTTT GACCAGACCA TTAATTTGAT TTTGGATGAA 
AGCCATGAAC GAGTATTCAG CTCTTCACAG GGGGTAGAAC AAGTGGTACT AGGATTATAC 
ATTGTAAGAG GTGACAACGT TGCAGTCATT GGAGAAATCG ATGAAGAAAC AGATTCTGCG 
CTTGATTTGG GGAATATTCG AGCAGAACCT TTAAATTCTG TAGCACACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057284.1
CDS	193..483
Translation	MTSALENYINRTVAVITSDGRMIVGTLKGFDQTINLILDESHERVFSSSQGVEQVVLGLYIVRGDNVAVIGEIDEETDSALDLGNIRAEPLNSVAH

Target ORF information:

RefSeq Version	NM_016200.4
Organism	Homo sapiens(human)
Definition	Homo sapiens LSM8 homolog, U6 small nuclear RNA associated (LSM8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016200.4

ORF Insert Sequence:

ATGACGTCCG CTTTGGAGAA CTACATCAAC CGAACTGTTG CCGTTATTAC ATCAGATGGG 
AGAATGATTG TGGGAACACT GAAAGGTTTT GACCAGACCA TTAATTTGAT TTTGGATGAA 
AGCCATGAAC GAGTATTCAG CTCTTCACAG GGGGTAGAAC AAGTGGTACT AGGATTATAC 
ATTGTAAGAG GTGACAACGT TGCAGTCATT GGAGAAATCG ATGAAGAAAC AGATTCTGCG 
CTTGATTTGG GGAATATTCG AGCAGAACCT TTAAATTCTG TAGCACACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.
Cell170(4)701-713.e11(2017 Aug)
Bertram K,Agafonov DE,Dybkov O,Haselbach D,Leelaram MN,Will CL,Urlaub H,Kastner B,L?hrmann R,Stark H

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Molecular architecture of the human U4/U6.U5 tri-snRNP.
Science (New York, N.Y.)351(6280)1416-20(2016 Mar)
Agafonov DE,Kastner B,Dybkov O,Hofele RV,Liu WT,Urlaub H,L?hrmann R,Stark H

Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.
The pharmacogenomics journal14(4)356-64(2014 Aug)
Cobb J,Cule E,Moncrieffe H,Hinks A,Ursu S,Patrick F,Kassoumeri L,Flynn E,Bulatovi? M,Wulffraat N,van Zelst B,de Jonge R,Bohm M,Dolezalova P,Hirani S,Newman S,Whitworth P,Southwood TR,De Iorio M,,,,Wedderburn LR,Thomson W

Nuclear LSm8 affects number of cytoplasmic processing bodies via controlling cellular distribution of Like-Sm proteins.
Molecular biology of the cell23(19)3776-85(2012 Oct)
Novotny I,Podolsk? K,Blaz?kov? M,Val?sek LS,Svoboda P,Stanek D

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LSM8 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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