MRPS23 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MRPS23
Entrez Gene ID	51649
Full Name	mitochondrial ribosomal protein S23
Synonyms	CGI-138,HSPC329,MRP-S23
General protein information	Preferred Names mitochondrial ribosomal protein S23 Names 28S ribosomal protein S23, mitochondrial S23mt mitochondrial small ribosomal subunit protein mS23
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q22
Summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 7p. [provided by RefSeq, Jul 2008].
Disorder MIM:	611985

mRNA and Protein(s)

mRNA	Protein	Name
NM_016070.3	NP_057154.2	28S ribosomal protein S23, mitochondrial
NM_016070.4	NP_057154.2	28S ribosomal protein S23, mitochondrial

Pathways from BioSystems

Homologies

Homo sapiens (human)	MRPS23	NP_057154.2
Gallus gallus (chicken)	MRPS23	XP_003642463.1
Bos taurus (cattle)	MRPS23	NP_001039657.1
Drosophila melanogaster (fruit fly)	mRpS23	NP_723847.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002893	XP_312017.5
Canis lupus familiaris (dog)	MRPS23	XP_852355.2
Mus musculus (house mouse)	Mrps23	NP_077136.2
Xenopus tropicalis (tropical clawed frog)	mrps23	XP_002932318.1
	MRPS23	XP_001105899.1
Pan troglodytes (chimpanzee)	MRPS23	XP_511903.2
Rattus norvegicus (Norway rat)	Mrps23	NP_001101759.1
Danio rerio (zebrafish)	mrps23	NP_001003615.1

Gene Ontology
Bibliography

Related articles in PubMed

Host factors that interact with the pestivirus N-terminal protease, Npro, are components of the ribonucleoprotein complex.
Jefferson M, Donaszi-Ivanov A, Pollen S, Dalmay T, Saalbach G, Powell PP
Journal of virology88(18)10340-53(2014 Sep)

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)

Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.
Zhang Z, Gerstein M
Genomics81(5)468-80(2003 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

The following MRPS23 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MRPS23 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09431	NM_016070.4 Latest version!	Homo sapiens mitochondrial ribosomal protein S23 (MRPS23), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu09431	NM_016070.3	Homo sapiens mitochondrial ribosomal protein S23 (MRPS23), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MRPS23 ( NM_016070.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057154.2 Homo sapiens mitochondrial ribosomal protein S23 (MRPS23), mRNA.

Price & Availability↑

CloneID	OHu09431
Clone ID Related Accession (Same CDS sequence)	NM_016070.3 , NM_016070.4
Accession Version	NM_016070.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 573bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	28S ribosomal protein S23, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX479815.1, BC000242.1, AF151896.1, AW299554.1 and BI962985.1. On Nov 18, 2010 this sequence version replaced NM_016070.2. ##Evidence-Data-START## Transcript exon combination :: DT220683.1, SRR1660805.26027.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2145245 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCAGGCA GCCGGCTGGA AACCGTAGGG AGCATCTTCT CTCGGACTCG GGACCTGGTT 
CGGGCCGGGG TGCTGAAGGA GAAGCCCCTG TGGTTTGACG TATATGACGC CTTTCCCCCG 
CTGAGGGAGC CCGTCTTCCA AAGGCCTCGA GTGCGATATG GCAAAGCCAA AGCTCCCATC 
CAAGACATCT GGTACCACGA GGATCGGATT AGAGCGAAGT TTTATTCAGT GTATGGGTCT 
GGTCAAAGAG CTTTTGATCT ATTCAATCCA AACTTCAAGT CTACCTGTCA ACGGTTTGTG 
GAGAAGTACA CTGAGCTACA GAAACTTGGA GAAACAGATG AAGAGAAGTT ATTTGTGGAA 
ACAGGGAAGG CTTTATTGGC AGAAGGTGTC ATTTTAAGAC GAGTAGGCGA AGCAAGGACT 
CAACACGGAG GTAGTCACGT TTCCCGGAAA TCCGAACACT TGAGTGTCAG ACCACAGACT 
GCGTTGGAAG AAAACGAGAC TCAGAAAGAA GTTCCACAGG ACCAGCATTT GGAGGCACCT 
GCAGACCAGT CGAAAGGTCT CTTGCCTCCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057154.2
CDS	63..635
Translation	MAGSRLETVGSIFSRTRDLVRAGVLKEKPLWFDVYDAFPPLREPVFQRPRVRYGKAKAPIQDIWYHEDRIRAKFYSVYGSGQRAFDLFNPNFKSTCQRFVEKYTELQKLGETDEEKLFVETGKALLAEGVILRRVGEARTQHGGSHVSRKSEHLSVRPQTALEENETQKEVPQDQHLEAPADQSKGLLPP

Target ORF information:

RefSeq Version	NM_016070.3
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein S23 (MRPS23), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016070.3

ORF Insert Sequence:

ATGGCAGGCA GCCGGCTGGA AACCGTAGGG AGCATCTTCT CTCGGACTCG GGACCTGGTT 
CGGGCCGGGG TGCTGAAGGA GAAGCCCCTG TGGTTTGACG TATATGACGC CTTTCCCCCG 
CTGAGGGAGC CCGTCTTCCA AAGGCCTCGA GTGCGATATG GCAAAGCCAA AGCTCCCATC 
CAAGACATCT GGTACCACGA GGATCGGATT AGAGCGAAGT TTTATTCAGT GTATGGGTCT 
GGTCAAAGAG CTTTTGATCT ATTCAATCCA AACTTCAAGT CTACCTGTCA ACGGTTTGTG 
GAGAAGTACA CTGAGCTACA GAAACTTGGA GAAACAGATG AAGAGAAGTT ATTTGTGGAA 
ACAGGGAAGG CTTTATTGGC AGAAGGTGTC ATTTTAAGAC GAGTAGGCGA AGCAAGGACT 
CAACACGGAG GTAGTCACGT TTCCCGGAAA TCCGAACACT TGAGTGTCAG ACCACAGACT 
GCGTTGGAAG AAAACGAGAC TCAGAAAGAA GTTCCACAGG ACCAGCATTT GGAGGCACCT 
GCAGACCAGT CGAAAGGTCT CTTGCCTCCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRPS23 ( NM_016070.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057154.2 Homo sapiens mitochondrial ribosomal protein S23 (MRPS23), mRNA.

Price & Availability↑

CloneID	OHu09431
Clone ID Related Accession (Same CDS sequence)	NM_016070.3 , NM_016070.4
Accession Version	NM_016070.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 573bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	28S ribosomal protein S23, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX479815.1, BC000242.1, AF151896.1, AW299554.1, BI962985.1 and AC015845.8. On Nov 23, 2018 this sequence version replaced NM_016070.3. ##Evidence-Data-START## Transcript exon combination :: BM846582.1, SRR1660805.26027.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2145245 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000313608.13/ ENSP00000320184.8 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCAGGCA GCCGGCTGGA AACCGTAGGG AGCATCTTCT CTCGGACTCG GGACCTGGTT 
CGGGCCGGGG TGCTGAAGGA GAAGCCCCTG TGGTTTGACG TATATGACGC CTTTCCCCCG 
CTGAGGGAGC CCGTCTTCCA AAGGCCTCGA GTGCGATATG GCAAAGCCAA AGCTCCCATC 
CAAGACATCT GGTACCACGA GGATCGGATT AGAGCGAAGT TTTATTCAGT GTATGGGTCT 
GGTCAAAGAG CTTTTGATCT ATTCAATCCA AACTTCAAGT CTACCTGTCA ACGGTTTGTG 
GAGAAGTACA CTGAGCTACA GAAACTTGGA GAAACAGATG AAGAGAAGTT ATTTGTGGAA 
ACAGGGAAGG CTTTATTGGC AGAAGGTGTC ATTTTAAGAC GAGTAGGCGA AGCAAGGACT 
CAACACGGAG GTAGTCACGT TTCCCGGAAA TCCGAACACT TGAGTGTCAG ACCACAGACT 
GCGTTGGAAG AAAACGAGAC TCAGAAAGAA GTTCCACAGG ACCAGCATTT GGAGGCACCT 
GCAGACCAGT CGAAAGGTCT CTTGCCTCCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057154.2
CDS	35..607
Translation	MAGSRLETVGSIFSRTRDLVRAGVLKEKPLWFDVYDAFPPLREPVFQRPRVRYGKAKAPIQDIWYHEDRIRAKFYSVYGSGQRAFDLFNPNFKSTCQRFVEKYTELQKLGETDEEKLFVETGKALLAEGVILRRVGEARTQHGGSHVSRKSEHLSVRPQTALEENETQKEVPQDQHLEAPADQSKGLLPP

Target ORF information:

RefSeq Version	NM_016070.4
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein S23 (MRPS23), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016070.4

ORF Insert Sequence:

ATGGCAGGCA GCCGGCTGGA AACCGTAGGG AGCATCTTCT CTCGGACTCG GGACCTGGTT 
CGGGCCGGGG TGCTGAAGGA GAAGCCCCTG TGGTTTGACG TATATGACGC CTTTCCCCCG 
CTGAGGGAGC CCGTCTTCCA AAGGCCTCGA GTGCGATATG GCAAAGCCAA AGCTCCCATC 
CAAGACATCT GGTACCACGA GGATCGGATT AGAGCGAAGT TTTATTCAGT GTATGGGTCT 
GGTCAAAGAG CTTTTGATCT ATTCAATCCA AACTTCAAGT CTACCTGTCA ACGGTTTGTG 
GAGAAGTACA CTGAGCTACA GAAACTTGGA GAAACAGATG AAGAGAAGTT ATTTGTGGAA 
ACAGGGAAGG CTTTATTGGC AGAAGGTGTC ATTTTAAGAC GAGTAGGCGA AGCAAGGACT 
CAACACGGAG GTAGTCACGT TTCCCGGAAA TCCGAACACT TGAGTGTCAG ACCACAGACT 
GCGTTGGAAG AAAACGAGAC TCAGAAAGAA GTTCCACAGG ACCAGCATTT GGAGGCACCT 
GCAGACCAGT CGAAAGGTCT CTTGCCTCCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Host factors that interact with the pestivirus N-terminal protease, Npro, are components of the ribonucleoprotein complex.
Journal of virology88(18)10340-53(2014 Sep)
Jefferson M,Donaszi-Ivanov A,Pollen S,Dalmay T,Saalbach G,Powell PP

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ

Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.
Genomics81(5)468-80(2003 May)
Zhang Z,Gerstein M

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MRPS23 cDNA ORF clone, Homo sapiens(human)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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