DYNC2LI1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DYNC2LI1
Entrez Gene ID	51626
Full Name	dynein cytoplasmic 2 light intermediate chain 1
Synonyms	CGI-60,D2LIC,LIC3
General protein information	Preferred Names dynein cytoplasmic 2 light intermediate chain 1 Names cytoplasmic dynein 2 light intermediate chain 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p21
Summary	This gene encodes a protein that is a component of the dynein-2 microtubule motor protein complex that plays a role in the retrograde transport of cargo in primary cilia via the intraflagellar transport system. This gene is ubiquitously expressed and its protein, which localizes to the axoneme and Golgi apparatus, interacts directly with the cytoplasmic dynein 2 heavy chain 1 protein to form part of the multi-protein dynein-2 complex. Mutations in this gene produce defects in the dynein-2 complex which result in several types of ciliopathy including short-rib thoracic dysplasia 15 with polydactyly (SRTD15). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017].
Disorder MIM:	617083
Disorder Html:	Short-rib thoracic dysplasia 15 with polydactyly, 617088 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_016008.4	NP_057092.2	cytoplasmic dynein 2 light intermediate chain 1 isoform 1
NM_001348913.1	NP_001335842.1	cytoplasmic dynein 2 light intermediate chain 1 isoform 6
NM_015522.3	NP_056337.1	cytoplasmic dynein 2 light intermediate chain 1 isoform 2
NM_001348912.1	NP_001335841.1	cytoplasmic dynein 2 light intermediate chain 1 isoform 5
NM_001193464.2	NP_001180393.1	cytoplasmic dynein 2 light intermediate chain 1 isoform 4
NM_016008.3	NP_057092.2	cytoplasmic dynein 2 light intermediate chain 1 isoform 1
NM_001193464.1	NP_001180393.1	cytoplasmic dynein 2 light intermediate chain 1 isoform 4

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	DYNC2LI1	XP_851613.1
Drosophila melanogaster (fruit fly)	CG3769	NP_609289.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010165	XP_319337.3
Xenopus tropicalis (tropical clawed frog)	LOC100498570	XP_002932438.2
Gallus gallus (chicken)	DYNC2LI1	XP_419456.3
Homo sapiens (human)	DYNC2LI1	NP_057092.2
Caenorhabditis elegans (roundworm)	xbx-1	NP_506683.2
Pan troglodytes (chimpanzee)	DYNC2LI1	XP_001142891.1
Danio rerio (zebrafish)	dync2li1	NP_956774.1
Xenopus tropicalis (tropical clawed frog)	dync2li1	XP_004914814.1
	LOC716480	XP_001107231.2
Bos taurus (cattle)	DYNC2LI1	NP_001033140.1
Mus musculus (house mouse)	Dync2li1	NP_758460.1

Gene Ontology
Bibliography

Related articles in PubMed

Biallelic mutations in DYNC2LI1 are a rare cause of Ellis-van Creveld syndrome.
Niceta M, Margiotti K, Digilio MC, Guida V, Bruselles A, Pizzi S, Ferraris A, Memo L, Laforgia N, Dentici ML, Consoli F, Torrente I, Ruiz-Perez VL, Dallapiccola B, Marino B, De Luca A, Tartaglia M
Clinical genetics(2017 Aug)

DYNC2LI1 mutations broaden the clinical spectrum of dynein-2 defects.
Kessler K, Wunderlich I, Uebe S, Falk NS, Gie?l A, Brandst?tter JH, Popp B, Klinger P, Ekici AB, Sticht H, D?rr HG, Reis A, Roepman R, Seemanov? E, Thiel CT
Scientific reports511649(2015 Jul)

Mutations in DYNC2LI1 disrupt cilia function and cause short rib polydactyly syndrome.
Taylor SP, Dantas TJ, Duran I, Wu S, Lachman RS, , Nelson SF, Cohn DH, Vallee RB, Krakow D
Nature communications67092(2015 Jun)

Recombinant human cytoplasmic dynein heavy chain 1 and 2: observation of dynein-2 motor activity in vitro.
Ichikawa M, Watanabe Y, Murayama T, Toyoshima YY
FEBS letters585(15)2419-23(2011 Aug)

BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins.
Gamerdinger M, Kaya AM, Wolfrum U, Clement AM, Behl C
EMBO reports12(2)149-56(2011 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

depletion of DYNC2LI1 induced altered cilia morphology with broadened ciliary tips and accumulation of intraflagellar transport complexes (IFT-B) complex proteins in accordance with retrograde IFT defects.
Title: DYNC2LI1 mutations broaden the clinical spectrum of dynein-2 defects.

DYNC2LI1 is essential for dynein-2 complex stability and that mutations in DYNC2LI1 result in variable length, including hyperelongated, cilia, Hedgehog pathway impairment and ciliary IFT accumulations, causing short rib polydactyly syndrome.
Title: Mutations in DYNC2LI1 disrupt cilia function and cause short rib polydactyly syndrome.

The following DYNC2LI1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DYNC2LI1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu32172	NM_001193464.2 Latest version!	Homo sapiens dynein cytoplasmic 2 light intermediate chain 1 (DYNC2LI1), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu55688	NM_015522.3 Latest version!	Homo sapiens dynein cytoplasmic 2 light intermediate chain 1 (DYNC2LI1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu02265	NM_016008.4 Latest version!	Homo sapiens dynein cytoplasmic 2 light intermediate chain 1 (DYNC2LI1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu35433	NM_001348913.1 Latest version!	Homo sapiens dynein cytoplasmic 2 light intermediate chain 1 (DYNC2LI1), transcript variant 6, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu35434	NM_001348912.1 Latest version!	Homo sapiens dynein cytoplasmic 2 light intermediate chain 1 (DYNC2LI1), transcript variant 5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
View Old Accession Versions >>
OHu02265	NM_016008.3	Homo sapiens dynein cytoplasmic 2 light intermediate chain 1 (DYNC2LI1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu32172	NM_001193464.1	Homo sapiens dynein cytoplasmic 2 light intermediate chain 1 (DYNC2LI1), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DYNC2LI1 ( NM_001193464.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001180393.1 Homo sapiens dynein cytoplasmic 2 light intermediate chain 1 (DYNC2LI1), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu32172
Clone ID Related Accession (Same CDS sequence)	NM_001193464.2 , NM_001193464.1
Accession Version	NM_001193464.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1059bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-15
Organism	Homo sapiens(human)
Product	cytoplasmic dynein 2 light intermediate chain 1 isoform 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK223432.1 and BC006969.1. On May 31, 2019 this sequence version replaced NM_001193464.1. Transcript Variant: This variant (4) uses an alternate in-frame splice site in the middle portion of the coding region, compared to variant 1. This results in a longer protein (isoform 4), compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.366667.1, BC006969.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCAGTG AAACTCTCTG GGAAATTGCA AAAGCTGAAG TGGAAAAAAG GGGAATTAAT 
GGAAGTGAAG GTGATGGAGC TGAAATTGCA GAAAAATTTG TTTTCTTCAT TGGCAGTAAA 
AATGGGGGAA AGACTACTAT TATTCTAAGG TGTCTTGACA GAGATGAACC ACCAAAACCA 
ACCTTAGCTT TGGAATATAC ATATGGAAGA AGAGCAAAAG GGCACAACAC ACCAAAAGAT 
ATCGCTCACT TTTGGGAACT CGGTGGAGGA ACCTCTTTAT TGGACTTAAT CAGCATACCC 
ATCACAGGTG ACACCTTACG GACGTTTTCT CTTGTTCTCG TTCTGGATCT TTCAAAACCT 
AATGATCTCT GGCCCACCAT GGAAAATCTC TTGCAAGCCA CAAAAAGCCA TGTAGACAAA 
GTGATAATGA AACTGGGAAA GACAAATGCT AAAGCAGTTT CTGAAATGAG ACAGAAGATC 
TGGAATAATA TGCCGAAGGA TCATCCTCAG GATCATGAAT TAATTGACCC ATTTCCGGTA 
CCTCTGGTCA TAATTGGAAG TAAATATGAT GTTTTTCAGG ATTTTGAGTC TGAGAAGAGA 
AAGGTAATAT GCAAGACACT TCGATTTGTT GCACATTATT ATGGAGCATC ATTAATGTTT 
ACCAGTAAAT CAGAAGCTCT ATTACTAAAA ATACGTGGAG TTATCAACCA GTTGGCATTT 
GGCATTGACA AAAGCAAATC AATATGTGTG GATCAGAATA AACCGCTGTT TATCACAGCA 
GGATTGGATT CTTTCGGTCA AATAGGATCT CCTCCTGTTC CTGAAAATGA CATTGGAAAG 
CTTCATGCCC ACTCACCTAT GGAGTTGTGG AAAAAAGTGT ATGAAAAGCT CTTTCCACCA 
AAGAGTATTA ACACGCTGAA AGATATCAAG GACCCTGCGA GAGATCCTCA GTATGCTGAA 
AATGAAGTCG ATGAGATGAG AATTCAGAAG GATCTGGAAC TGGAACAGTA CAAAAGAAGT 
TCTTCCAAGT CTTGGAAACA AATCGAGCTT GATTCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001180393.1
CDS	101..1159
Translation	MPSETLWEIAKAEVEKRGINGSEGDGAEIAEKFVFFIGSKNGGKTTIILRCLDRDEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSLVLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPQDHELIDPFPVPLVIIGSKYDVFQDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLAFGIDKSKSICVDQNKPLFITAGLDSFGQIGSPPVPENDIGKLHAHSPMELWKKVYEKLFPPKSINTLKDIKDPARDPQYAENEVDEMRIQKDLELEQYKRSSSKSWKQIELDS

Target ORF information:

RefSeq Version	NM_001193464.2
Organism	Homo sapiens(human)
Definition	Homo sapiens dynein cytoplasmic 2 light intermediate chain 1 (DYNC2LI1), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001193464.2

ORF Insert Sequence:

ATGCCCAGTG AAACTCTCTG GGAAATTGCA AAAGCTGAAG TGGAAAAAAG GGGAATTAAT 
GGAAGTGAAG GTGATGGAGC TGAAATTGCA GAAAAATTTG TTTTCTTCAT TGGCAGTAAA 
AATGGGGGAA AGACTACTAT TATTCTAAGG TGTCTTGACA GAGATGAACC ACCAAAACCA 
ACCTTAGCTT TGGAATATAC ATATGGAAGA AGAGCAAAAG GGCACAACAC ACCAAAAGAT 
ATCGCTCACT TTTGGGAACT CGGTGGAGGA ACCTCTTTAT TGGACTTAAT CAGCATACCC 
ATCACAGGTG ACACCTTACG GACGTTTTCT CTTGTTCTCG TTCTGGATCT TTCAAAACCT 
AATGATCTCT GGCCCACCAT GGAAAATCTC TTGCAAGCCA CAAAAAGCCA TGTAGACAAA 
GTGATAATGA AACTGGGAAA GACAAATGCT AAAGCAGTTT CTGAAATGAG ACAGAAGATC 
TGGAATAATA TGCCGAAGGA TCATCCTCAG GATCATGAAT TAATTGACCC ATTTCCGGTA 
CCTCTGGTCA TAATTGGAAG TAAATATGAT GTTTTTCAGG ATTTTGAGTC TGAGAAGAGA 
AAGGTAATAT GCAAGACACT TCGATTTGTT GCACATTATT ATGGAGCATC ATTAATGTTT 
ACCAGTAAAT CAGAAGCTCT ATTACTAAAA ATACGTGGAG TTATCAACCA GTTGGCATTT 
GGCATTGACA AAAGCAAATC AATATGTGTG GATCAGAATA AACCGCTGTT TATCACAGCA 
GGATTGGATT CTTTCGGTCA AATAGGATCT CCTCCTGTTC CTGAAAATGA CATTGGAAAG 
CTTCATGCCC ACTCACCTAT GGAGTTGTGG AAAAAAGTGT ATGAAAAGCT CTTTCCACCA 
AAGAGTATTA ACACGCTGAA AGATATCAAG GACCCTGCGA GAGATCCTCA GTATGCTGAA 
AATGAAGTCG ATGAGATGAG AATTCAGAAG GATCTGGAAC TGGAACAGTA CAAAAGAAGT 
TCTTCCAAGT CTTGGAAACA AATCGAGCTT GATTCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DYNC2LI1 ( NM_001193464.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001180393.1 Homo sapiens dynein cytoplasmic 2 light intermediate chain 1 (DYNC2LI1), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu32172
Clone ID Related Accession (Same CDS sequence)	NM_001193464.2 , NM_001193464.1
Accession Version	NM_001193464.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1059bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	cytoplasmic dynein 2 light intermediate chain 1 isoform 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK223432.1 and BC006969.1. Transcript Variant: This variant (4) uses an alternate in-frame splice site in the middle portion of the coding region, compared to variant 1. This results in a longer protein (isoform 4), compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.366667.1, BC006969.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCAGTG AAACTCTCTG GGAAATTGCA AAAGCTGAAG TGGAAAAAAG GGGAATTAAT 
GGAAGTGAAG GTGATGGAGC TGAAATTGCA GAAAAATTTG TTTTCTTCAT TGGCAGTAAA 
AATGGGGGAA AGACTACTAT TATTCTAAGG TGTCTTGACA GAGATGAACC ACCAAAACCA 
ACCTTAGCTT TGGAATATAC ATATGGAAGA AGAGCAAAAG GGCACAACAC ACCAAAAGAT 
ATCGCTCACT TTTGGGAACT CGGTGGAGGA ACCTCTTTAT TGGACTTAAT CAGCATACCC 
ATCACAGGTG ACACCTTACG GACGTTTTCT CTTGTTCTCG TTCTGGATCT TTCAAAACCT 
AATGATCTCT GGCCCACCAT GGAAAATCTC TTGCAAGCCA CAAAAAGCCA TGTAGACAAA 
GTGATAATGA AACTGGGAAA GACAAATGCT AAAGCAGTTT CTGAAATGAG ACAGAAGATC 
TGGAATAATA TGCCGAAGGA TCATCCTCAG GATCATGAAT TAATTGACCC ATTTCCGGTA 
CCTCTGGTCA TAATTGGAAG TAAATATGAT GTTTTTCAGG ATTTTGAGTC TGAGAAGAGA 
AAGGTAATAT GCAAGACACT TCGATTTGTT GCACATTATT ATGGAGCATC ATTAATGTTT 
ACCAGTAAAT CAGAAGCTCT ATTACTAAAA ATACGTGGAG TTATCAACCA GTTGGCATTT 
GGCATTGACA AAAGCAAATC AATATGTGTG GATCAGAATA AACCGCTGTT TATCACAGCA 
GGATTGGATT CTTTCGGTCA AATAGGATCT CCTCCTGTTC CTGAAAATGA CATTGGAAAG 
CTTCATGCCC ACTCACCTAT GGAGTTGTGG AAAAAAGTGT ATGAAAAGCT CTTTCCACCA 
AAGAGTATTA ACACGCTGAA AGATATCAAG GACCCTGCGA GAGATCCTCA GTATGCTGAA 
AATGAAGTCG ATGAGATGAG AATTCAGAAG GATCTGGAAC TGGAACAGTA CAAAAGAAGT 
TCTTCCAAGT CTTGGAAACA AATCGAGCTT GATTCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001180393.1
CDS	101..1159
Translation	MPSETLWEIAKAEVEKRGINGSEGDGAEIAEKFVFFIGSKNGGKTTIILRCLDRDEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSLVLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPQDHELIDPFPVPLVIIGSKYDVFQDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLAFGIDKSKSICVDQNKPLFITAGLDSFGQIGSPPVPENDIGKLHAHSPMELWKKVYEKLFPPKSINTLKDIKDPARDPQYAENEVDEMRIQKDLELEQYKRSSSKSWKQIELDS

Target ORF information:

RefSeq Version	NM_001193464.1
Organism	Homo sapiens(human)
Definition	Homo sapiens dynein cytoplasmic 2 light intermediate chain 1 (DYNC2LI1), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001193464.1

ORF Insert Sequence:

ATGCCCAGTG AAACTCTCTG GGAAATTGCA AAAGCTGAAG TGGAAAAAAG GGGAATTAAT 
GGAAGTGAAG GTGATGGAGC TGAAATTGCA GAAAAATTTG TTTTCTTCAT TGGCAGTAAA 
AATGGGGGAA AGACTACTAT TATTCTAAGG TGTCTTGACA GAGATGAACC ACCAAAACCA 
ACCTTAGCTT TGGAATATAC ATATGGAAGA AGAGCAAAAG GGCACAACAC ACCAAAAGAT 
ATCGCTCACT TTTGGGAACT CGGTGGAGGA ACCTCTTTAT TGGACTTAAT CAGCATACCC 
ATCACAGGTG ACACCTTACG GACGTTTTCT CTTGTTCTCG TTCTGGATCT TTCAAAACCT 
AATGATCTCT GGCCCACCAT GGAAAATCTC TTGCAAGCCA CAAAAAGCCA TGTAGACAAA 
GTGATAATGA AACTGGGAAA GACAAATGCT AAAGCAGTTT CTGAAATGAG ACAGAAGATC 
TGGAATAATA TGCCGAAGGA TCATCCTCAG GATCATGAAT TAATTGACCC ATTTCCGGTA 
CCTCTGGTCA TAATTGGAAG TAAATATGAT GTTTTTCAGG ATTTTGAGTC TGAGAAGAGA 
AAGGTAATAT GCAAGACACT TCGATTTGTT GCACATTATT ATGGAGCATC ATTAATGTTT 
ACCAGTAAAT CAGAAGCTCT ATTACTAAAA ATACGTGGAG TTATCAACCA GTTGGCATTT 
GGCATTGACA AAAGCAAATC AATATGTGTG GATCAGAATA AACCGCTGTT TATCACAGCA 
GGATTGGATT CTTTCGGTCA AATAGGATCT CCTCCTGTTC CTGAAAATGA CATTGGAAAG 
CTTCATGCCC ACTCACCTAT GGAGTTGTGG AAAAAAGTGT ATGAAAAGCT CTTTCCACCA 
AAGAGTATTA ACACGCTGAA AGATATCAAG GACCCTGCGA GAGATCCTCA GTATGCTGAA 
AATGAAGTCG ATGAGATGAG AATTCAGAAG GATCTGGAAC TGGAACAGTA CAAAAGAAGT 
TCTTCCAAGT CTTGGAAACA AATCGAGCTT GATTCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DYNC2LI1 ( NM_015522.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_056337.1 Homo sapiens dynein cytoplasmic 2 light intermediate chain 1 (DYNC2LI1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu55688
Clone ID Related Accession (Same CDS sequence)	NM_015522.3
Accession Version	NM_015522.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 606bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-15
Organism	Homo sapiens(human)
Product	cytoplasmic dynein 2 light intermediate chain 1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK223432.1, BC016324.1 and CB528979.1. On Jul 28, 2010 this sequence version replaced NM_015522.2. Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: BC058823.1, BC016324.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCAGTG AAACTCTCTG GGAAATTGCA AAAGCTGAAG TGGAAAAAAG GGGAATTAAT 
GGAAGTGAAG GTGATGGAGC TGAAATTGCA GAAAAATTTG TTTTCTTCAT TGGCAGTAAA 
AATGGGGGAA AGACTACTAT TATTCTAAGG TGTCTTGACA GAGATGAACC ACCAAAACCA 
ACCTTAGCTT TGGAATATAC ATATGGAAGA AGAGCAAAAG GGCACAACAC ACCAAAAGAT 
ATCGCTCACT TTTGGGAACT CGGTGGAGGA ACCTCTTTAT TGGACTTAAT CAGCATACCC 
ATCACAGGTG ACACCTTACG GACGTTTTCT CTTGTTCTCG TTCTGGATCT TTCAAAACCT 
AATGATCTCT GGCCCACCAT GGAAAATCTC TTGCAAGCCA CAAAAAGCCA TGTAGACAAA 
GTGATAATGA AACTGGGAAA GACAAATGCT AAAGCAGTTT CTGAAATGAG ACAGAAGATC 
TGGAATAATA TGCCGAAGGA TCATCCTGTG AGTTGCTGTT TGGGATTATT ACTGGAATCC 
TTAGTCCCAT TTATAGTTAA TGATAACATC ACAAACAACT TCTTTAGATT TTTATGCATG 
ACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056337.1
CDS	101..706
Translation	MPSETLWEIAKAEVEKRGINGSEGDGAEIAEKFVFFIGSKNGGKTTIILRCLDRDEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSLVLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPVSCCLGLLLESLVPFIVNDNITNNFFRFLCMT

Target ORF information:

RefSeq Version	NM_015522.3
Organism	Homo sapiens(human)
Definition	Homo sapiens dynein cytoplasmic 2 light intermediate chain 1 (DYNC2LI1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015522.3

ORF Insert Sequence:

ATGCCCAGTG AAACTCTCTG GGAAATTGCA AAAGCTGAAG TGGAAAAAAG GGGAATTAAT 
GGAAGTGAAG GTGATGGAGC TGAAATTGCA GAAAAATTTG TTTTCTTCAT TGGCAGTAAA 
AATGGGGGAA AGACTACTAT TATTCTAAGG TGTCTTGACA GAGATGAACC ACCAAAACCA 
ACCTTAGCTT TGGAATATAC ATATGGAAGA AGAGCAAAAG GGCACAACAC ACCAAAAGAT 
ATCGCTCACT TTTGGGAACT CGGTGGAGGA ACCTCTTTAT TGGACTTAAT CAGCATACCC 
ATCACAGGTG ACACCTTACG GACGTTTTCT CTTGTTCTCG TTCTGGATCT TTCAAAACCT 
AATGATCTCT GGCCCACCAT GGAAAATCTC TTGCAAGCCA CAAAAAGCCA TGTAGACAAA 
GTGATAATGA AACTGGGAAA GACAAATGCT AAAGCAGTTT CTGAAATGAG ACAGAAGATC 
TGGAATAATA TGCCGAAGGA TCATCCTGTG AGTTGCTGTT TGGGATTATT ACTGGAATCC 
TTAGTCCCAT TTATAGTTAA TGATAACATC ACAAACAACT TCTTTAGATT TTTATGCATG 
ACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DYNC2LI1 ( NM_016008.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057092.2 Homo sapiens dynein cytoplasmic 2 light intermediate chain 1 (DYNC2LI1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu02265
Clone ID Related Accession (Same CDS sequence)	NM_016008.4 , NM_016008.3
Accession Version	NM_016008.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1056bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-15
Organism	Homo sapiens(human)
Product	cytoplasmic dynein 2 light intermediate chain 1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK223432.1 and AY083346.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_016008.3. Transcript Variant: This variant (1) encodes isoform 1. ##Evidence-Data-START## Transcript exon combination :: AK223432.1, SRR5189655.69418.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000260605.12/ ENSP00000260605.8 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCCAGTG AAACTCTCTG GGAAATTGCA AAAGCTGAAG TGGAAAAAAG GGGAATTAAT 
GGAAGTGAAG GTGATGGAGC TGAAATTGCA GAAAAATTTG TTTTCTTCAT TGGCAGTAAA 
AATGGGGGAA AGACTACTAT TATTCTAAGG TGTCTTGACA GAGATGAACC ACCAAAACCA 
ACCTTAGCTT TGGAATATAC ATATGGAAGA AGAGCAAAAG GGCACAACAC ACCAAAAGAT 
ATCGCTCACT TTTGGGAACT CGGTGGAGGA ACCTCTTTAT TGGACTTAAT CAGCATACCC 
ATCACAGGTG ACACCTTACG GACGTTTTCT CTTGTTCTCG TTCTGGATCT TTCAAAACCT 
AATGATCTCT GGCCCACCAT GGAAAATCTC TTGCAAGCCA CAAAAAGCCA TGTAGACAAA 
GTGATAATGA AACTGGGAAA GACAAATGCT AAAGCAGTTT CTGAAATGAG ACAGAAGATC 
TGGAATAATA TGCCGAAGGA TCATCCTGAT CATGAATTAA TTGACCCATT TCCGGTACCT 
CTGGTCATAA TTGGAAGTAA ATATGATGTT TTTCAGGATT TTGAGTCTGA GAAGAGAAAG 
GTAATATGCA AGACACTTCG ATTTGTTGCA CATTATTATG GAGCATCATT AATGTTTACC 
AGTAAATCAG AAGCTCTATT ACTAAAAATA CGTGGAGTTA TCAACCAGTT GGCATTTGGC 
ATTGACAAAA GCAAATCAAT ATGTGTGGAT CAGAATAAAC CGCTGTTTAT CACAGCAGGA 
TTGGATTCTT TCGGTCAAAT AGGATCTCCT CCTGTTCCTG AAAATGACAT TGGAAAGCTT 
CATGCCCACT CACCTATGGA GTTGTGGAAA AAAGTGTATG AAAAGCTCTT TCCACCAAAG 
AGTATTAACA CGCTGAAAGA TATCAAGGAC CCTGCGAGAG ATCCTCAGTA TGCTGAAAAT 
GAAGTCGATG AGATGAGAAT TCAGAAGGAT CTGGAACTGG AACAGTACAA AAGAAGTTCT 
TCCAAGTCTT GGAAACAAAT CGAGCTTGAT TCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057092.2
CDS	101..1156
Translation	MPSETLWEIAKAEVEKRGINGSEGDGAEIAEKFVFFIGSKNGGKTTIILRCLDRDEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSLVLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVFQDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLAFGIDKSKSICVDQNKPLFITAGLDSFGQIGSPPVPENDIGKLHAHSPMELWKKVYEKLFPPKSINTLKDIKDPARDPQYAENEVDEMRIQKDLELEQYKRSSSKSWKQIELDS

Target ORF information:

RefSeq Version	NM_016008.4
Organism	Homo sapiens(human)
Definition	Homo sapiens dynein cytoplasmic 2 light intermediate chain 1 (DYNC2LI1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016008.4

ORF Insert Sequence:

ATGCCCAGTG AAACTCTCTG GGAAATTGCA AAAGCTGAAG TGGAAAAAAG GGGAATTAAT 
GGAAGTGAAG GTGATGGAGC TGAAATTGCA GAAAAATTTG TTTTCTTCAT TGGCAGTAAA 
AATGGGGGAA AGACTACTAT TATTCTAAGG TGTCTTGACA GAGATGAACC ACCAAAACCA 
ACCTTAGCTT TGGAATATAC ATATGGAAGA AGAGCAAAAG GGCACAACAC ACCAAAAGAT 
ATCGCTCACT TTTGGGAACT CGGTGGAGGA ACCTCTTTAT TGGACTTAAT CAGCATACCC 
ATCACAGGTG ACACCTTACG GACGTTTTCT CTTGTTCTCG TTCTGGATCT TTCAAAACCT 
AATGATCTCT GGCCCACCAT GGAAAATCTC TTGCAAGCCA CAAAAAGCCA TGTAGACAAA 
GTGATAATGA AACTGGGAAA GACAAATGCT AAAGCAGTTT CTGAAATGAG ACAGAAGATC 
TGGAATAATA TGCCGAAGGA TCATCCTGAT CATGAATTAA TTGACCCATT TCCGGTACCT 
CTGGTCATAA TTGGAAGTAA ATATGATGTT TTTCAGGATT TTGAGTCTGA GAAGAGAAAG 
GTAATATGCA AGACACTTCG ATTTGTTGCA CATTATTATG GAGCATCATT AATGTTTACC 
AGTAAATCAG AAGCTCTATT ACTAAAAATA CGTGGAGTTA TCAACCAGTT GGCATTTGGC 
ATTGACAAAA GCAAATCAAT ATGTGTGGAT CAGAATAAAC CGCTGTTTAT CACAGCAGGA 
TTGGATTCTT TCGGTCAAAT AGGATCTCCT CCTGTTCCTG AAAATGACAT TGGAAAGCTT 
CATGCCCACT CACCTATGGA GTTGTGGAAA AAAGTGTATG AAAAGCTCTT TCCACCAAAG 
AGTATTAACA CGCTGAAAGA TATCAAGGAC CCTGCGAGAG ATCCTCAGTA TGCTGAAAAT 
GAAGTCGATG AGATGAGAAT TCAGAAGGAT CTGGAACTGG AACAGTACAA AAGAAGTTCT 
TCCAAGTCTT GGAAACAAAT CGAGCTTGAT TCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DYNC2LI1 ( NM_016008.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057092.2 Homo sapiens dynein cytoplasmic 2 light intermediate chain 1 (DYNC2LI1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu02265
Clone ID Related Accession (Same CDS sequence)	NM_016008.4 , NM_016008.3
Accession Version	NM_016008.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1056bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Homo sapiens(human)
Product	cytoplasmic dynein 2 light intermediate chain 1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK223432.1 and AY083346.1. This sequence is a reference standard in the RefSeqGene project. On Jul 28, 2010 this sequence version replaced NM_016008.2. Transcript Variant: This variant (1) encodes isoform 1. ##Evidence-Data-START## Transcript exon combination :: AK223432.1, AK074206.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCAGTG AAACTCTCTG GGAAATTGCA AAAGCTGAAG TGGAAAAAAG GGGAATTAAT 
GGAAGTGAAG GTGATGGAGC TGAAATTGCA GAAAAATTTG TTTTCTTCAT TGGCAGTAAA 
AATGGGGGAA AGACTACTAT TATTCTAAGG TGTCTTGACA GAGATGAACC ACCAAAACCA 
ACCTTAGCTT TGGAATATAC ATATGGAAGA AGAGCAAAAG GGCACAACAC ACCAAAAGAT 
ATCGCTCACT TTTGGGAACT CGGTGGAGGA ACCTCTTTAT TGGACTTAAT CAGCATACCC 
ATCACAGGTG ACACCTTACG GACGTTTTCT CTTGTTCTCG TTCTGGATCT TTCAAAACCT 
AATGATCTCT GGCCCACCAT GGAAAATCTC TTGCAAGCCA CAAAAAGCCA TGTAGACAAA 
GTGATAATGA AACTGGGAAA GACAAATGCT AAAGCAGTTT CTGAAATGAG ACAGAAGATC 
TGGAATAATA TGCCGAAGGA TCATCCTGAT CATGAATTAA TTGACCCATT TCCGGTACCT 
CTGGTCATAA TTGGAAGTAA ATATGATGTT TTTCAGGATT TTGAGTCTGA GAAGAGAAAG 
GTAATATGCA AGACACTTCG ATTTGTTGCA CATTATTATG GAGCATCATT AATGTTTACC 
AGTAAATCAG AAGCTCTATT ACTAAAAATA CGTGGAGTTA TCAACCAGTT GGCATTTGGC 
ATTGACAAAA GCAAATCAAT ATGTGTGGAT CAGAATAAAC CGCTGTTTAT CACAGCAGGA 
TTGGATTCTT TCGGTCAAAT AGGATCTCCT CCTGTTCCTG AAAATGACAT TGGAAAGCTT 
CATGCCCACT CACCTATGGA GTTGTGGAAA AAAGTGTATG AAAAGCTCTT TCCACCAAAG 
AGTATTAACA CGCTGAAAGA TATCAAGGAC CCTGCGAGAG ATCCTCAGTA TGCTGAAAAT 
GAAGTCGATG AGATGAGAAT TCAGAAGGAT CTGGAACTGG AACAGTACAA AAGAAGTTCT 
TCCAAGTCTT GGAAACAAAT CGAGCTTGAT TCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057092.2
CDS	101..1156
Translation	MPSETLWEIAKAEVEKRGINGSEGDGAEIAEKFVFFIGSKNGGKTTIILRCLDRDEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSLVLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVFQDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLAFGIDKSKSICVDQNKPLFITAGLDSFGQIGSPPVPENDIGKLHAHSPMELWKKVYEKLFPPKSINTLKDIKDPARDPQYAENEVDEMRIQKDLELEQYKRSSSKSWKQIELDS

Target ORF information:

RefSeq Version	NM_016008.3
Organism	Homo sapiens(human)
Definition	Homo sapiens dynein cytoplasmic 2 light intermediate chain 1 (DYNC2LI1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016008.3

ORF Insert Sequence:

ATGCCCAGTG AAACTCTCTG GGAAATTGCA AAAGCTGAAG TGGAAAAAAG GGGAATTAAT 
GGAAGTGAAG GTGATGGAGC TGAAATTGCA GAAAAATTTG TTTTCTTCAT TGGCAGTAAA 
AATGGGGGAA AGACTACTAT TATTCTAAGG TGTCTTGACA GAGATGAACC ACCAAAACCA 
ACCTTAGCTT TGGAATATAC ATATGGAAGA AGAGCAAAAG GGCACAACAC ACCAAAAGAT 
ATCGCTCACT TTTGGGAACT CGGTGGAGGA ACCTCTTTAT TGGACTTAAT CAGCATACCC 
ATCACAGGTG ACACCTTACG GACGTTTTCT CTTGTTCTCG TTCTGGATCT TTCAAAACCT 
AATGATCTCT GGCCCACCAT GGAAAATCTC TTGCAAGCCA CAAAAAGCCA TGTAGACAAA 
GTGATAATGA AACTGGGAAA GACAAATGCT AAAGCAGTTT CTGAAATGAG ACAGAAGATC 
TGGAATAATA TGCCGAAGGA TCATCCTGAT CATGAATTAA TTGACCCATT TCCGGTACCT 
CTGGTCATAA TTGGAAGTAA ATATGATGTT TTTCAGGATT TTGAGTCTGA GAAGAGAAAG 
GTAATATGCA AGACACTTCG ATTTGTTGCA CATTATTATG GAGCATCATT AATGTTTACC 
AGTAAATCAG AAGCTCTATT ACTAAAAATA CGTGGAGTTA TCAACCAGTT GGCATTTGGC 
ATTGACAAAA GCAAATCAAT ATGTGTGGAT CAGAATAAAC CGCTGTTTAT CACAGCAGGA 
TTGGATTCTT TCGGTCAAAT AGGATCTCCT CCTGTTCCTG AAAATGACAT TGGAAAGCTT 
CATGCCCACT CACCTATGGA GTTGTGGAAA AAAGTGTATG AAAAGCTCTT TCCACCAAAG 
AGTATTAACA CGCTGAAAGA TATCAAGGAC CCTGCGAGAG ATCCTCAGTA TGCTGAAAAT 
GAAGTCGATG AGATGAGAAT TCAGAAGGAT CTGGAACTGG AACAGTACAA AAGAAGTTCT 
TCCAAGTCTT GGAAACAAAT CGAGCTTGAT TCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DYNC2LI1 ( NM_001348913.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001335842.1 Homo sapiens dynein cytoplasmic 2 light intermediate chain 1 (DYNC2LI1), transcript variant 6, mRNA.

Price & Availability↑

CloneID	OHu35433
Clone ID Related Accession (Same CDS sequence)	NM_001348913.1
Accession Version	NM_001348913.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1125bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-15
Organism	Homo sapiens(human)
Product	cytoplasmic dynein 2 light intermediate chain 1 isoform 6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC011242.8 and AC108476.5. On Feb 19, 2017 this sequence version replaced XM_005264364.4. Transcript Variant: This variant (6) uses an alternate in-frame splice site in the middle portion of the coding region and has multiple differences at its 3' end, compared to variant 1. This results in a longer protein (isoform 6) with a distinct C-terminus, compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.207974.1, SRR1660805.122244.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144333, SAMEA2145245 [ECO:0000348] ##Evidence-Data-END##

ATGCCCAGTG AAACTCTCTG GGAAATTGCA AAAGCTGAAG TGGAAAAAAG GGGAATTAAT 
GGAAGTGAAG GTGATGGAGC TGAAATTGCA GAAAAATTTG TTTTCTTCAT TGGCAGTAAA 
AATGGGGGAA AGACTACTAT TATTCTAAGG TGTCTTGACA GAGATGAACC ACCAAAACCA 
ACCTTAGCTT TGGAATATAC ATATGGAAGA AGAGCAAAAG GGCACAACAC ACCAAAAGAT 
ATCGCTCACT TTTGGGAACT CGGTGGAGGA ACCTCTTTAT TGGACTTAAT CAGCATACCC 
ATCACAGGTG ACACCTTACG GACGTTTTCT CTTGTTCTCG TTCTGGATCT TTCAAAACCT 
AATGATCTCT GGCCCACCAT GGAAAATCTC TTGCAAGCCA CAAAAAGCCA TGTAGACAAA 
GTGATAATGA AACTGGGAAA GACAAATGCT AAAGCAGTTT CTGAAATGAG ACAGAAGATC 
TGGAATAATA TGCCGAAGGA TCATCCTCAG GATCATGAAT TAATTGACCC ATTTCCGGTA 
CCTCTGGTCA TAATTGGAAG TAAATATGAT GTTTTTCAGG ATTTTGAGTC TGAGAAGAGA 
AAGGTAATAT GCAAGACACT TCGATTTGTT GCACATTATT ATGGAGCATC ATTAATGTTT 
ACCAGTAAAT CAGAAGCTCT ATTACTAAAA ATACGTGGAG TTATCAACCA GTTGGCATTT 
GGCATTGACA AAAGCAAATC AATATGTGTG GATCAGAATA AACCGCTGTT TATCACAGCA 
GGATTGGATT CTTTCGGTCA AATAGGATCT CCTCCTGTTC CTGAAAATGA CATTGGAAAG 
CTTCATGCCC ACTCACCTAT GGAGTTGTGG AAAAAAGTGT ATGAAAAGCT CTTTCCACCA 
AAGAGTATTA ACACGCTGAA AGATATCAAG GACCCTGCGA GAGATCCTCA GTATGCTGAA 
AATGAAGTCG ATGAGATGAG AATTCAGAAG GATCTGGCAC ATCTAAGGAG ATATCCTATC 
AAGAAGCAGG ACAAAACATC ATGTGTTGCG GATAACCAGG ATTATTTCCA AGGTGGGATA 
GCCTTTAAGA AGCCATTCCA ATCTGTAGAT GTGTGTACCT GCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001335842.1
CDS	101..1225
Translation	MPSETLWEIAKAEVEKRGINGSEGDGAEIAEKFVFFIGSKNGGKTTIILRCLDRDEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSLVLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPQDHELIDPFPVPLVIIGSKYDVFQDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLAFGIDKSKSICVDQNKPLFITAGLDSFGQIGSPPVPENDIGKLHAHSPMELWKKVYEKLFPPKSINTLKDIKDPARDPQYAENEVDEMRIQKDLAHLRRYPIKKQDKTSCVADNQDYFQGGIAFKKPFQSVDVCTC

Target ORF information:

RefSeq Version	NM_001348913.1
Organism	Homo sapiens(human)
Definition	Homo sapiens dynein cytoplasmic 2 light intermediate chain 1 (DYNC2LI1), transcript variant 6, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001348913.1

ORF Insert Sequence:

ATGCCCAGTG AAACTCTCTG GGAAATTGCA AAAGCTGAAG TGGAAAAAAG GGGAATTAAT 
GGAAGTGAAG GTGATGGAGC TGAAATTGCA GAAAAATTTG TTTTCTTCAT TGGCAGTAAA 
AATGGGGGAA AGACTACTAT TATTCTAAGG TGTCTTGACA GAGATGAACC ACCAAAACCA 
ACCTTAGCTT TGGAATATAC ATATGGAAGA AGAGCAAAAG GGCACAACAC ACCAAAAGAT 
ATCGCTCACT TTTGGGAACT CGGTGGAGGA ACCTCTTTAT TGGACTTAAT CAGCATACCC 
ATCACAGGTG ACACCTTACG GACGTTTTCT CTTGTTCTCG TTCTGGATCT TTCAAAACCT 
AATGATCTCT GGCCCACCAT GGAAAATCTC TTGCAAGCCA CAAAAAGCCA TGTAGACAAA 
GTGATAATGA AACTGGGAAA GACAAATGCT AAAGCAGTTT CTGAAATGAG ACAGAAGATC 
TGGAATAATA TGCCGAAGGA TCATCCTCAG GATCATGAAT TAATTGACCC ATTTCCGGTA 
CCTCTGGTCA TAATTGGAAG TAAATATGAT GTTTTTCAGG ATTTTGAGTC TGAGAAGAGA 
AAGGTAATAT GCAAGACACT TCGATTTGTT GCACATTATT ATGGAGCATC ATTAATGTTT 
ACCAGTAAAT CAGAAGCTCT ATTACTAAAA ATACGTGGAG TTATCAACCA GTTGGCATTT 
GGCATTGACA AAAGCAAATC AATATGTGTG GATCAGAATA AACCGCTGTT TATCACAGCA 
GGATTGGATT CTTTCGGTCA AATAGGATCT CCTCCTGTTC CTGAAAATGA CATTGGAAAG 
CTTCATGCCC ACTCACCTAT GGAGTTGTGG AAAAAAGTGT ATGAAAAGCT CTTTCCACCA 
AAGAGTATTA ACACGCTGAA AGATATCAAG GACCCTGCGA GAGATCCTCA GTATGCTGAA 
AATGAAGTCG ATGAGATGAG AATTCAGAAG GATCTGGCAC ATCTAAGGAG ATATCCTATC 
AAGAAGCAGG ACAAAACATC ATGTGTTGCG GATAACCAGG ATTATTTCCA AGGTGGGATA 
GCCTTTAAGA AGCCATTCCA ATCTGTAGAT GTGTGTACCT GCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DYNC2LI1 ( NM_001348912.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001335841.1 Homo sapiens dynein cytoplasmic 2 light intermediate chain 1 (DYNC2LI1), transcript variant 5, mRNA.

Price & Availability↑

CloneID	OHu35434
Clone ID Related Accession (Same CDS sequence)	NM_001348912.1
Accession Version	NM_001348912.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1122bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-15
Organism	Homo sapiens(human)
Product	cytoplasmic dynein 2 light intermediate chain 1 isoform 5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC011242.8 and AC108476.5. On Feb 19, 2017 this sequence version replaced XM_005264365.4. Transcript Variant: This variant (5) has multiple differences at its 3' end, compared to variant 1. This results in a longer protein (isoform 5) with a distinct C-terminus, compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.209359.1, SRR1803617.112094.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144333, SAMEA2145245 [ECO:0000348] ##Evidence-Data-END##

ATGCCCAGTG AAACTCTCTG GGAAATTGCA AAAGCTGAAG TGGAAAAAAG GGGAATTAAT 
GGAAGTGAAG GTGATGGAGC TGAAATTGCA GAAAAATTTG TTTTCTTCAT TGGCAGTAAA 
AATGGGGGAA AGACTACTAT TATTCTAAGG TGTCTTGACA GAGATGAACC ACCAAAACCA 
ACCTTAGCTT TGGAATATAC ATATGGAAGA AGAGCAAAAG GGCACAACAC ACCAAAAGAT 
ATCGCTCACT TTTGGGAACT CGGTGGAGGA ACCTCTTTAT TGGACTTAAT CAGCATACCC 
ATCACAGGTG ACACCTTACG GACGTTTTCT CTTGTTCTCG TTCTGGATCT TTCAAAACCT 
AATGATCTCT GGCCCACCAT GGAAAATCTC TTGCAAGCCA CAAAAAGCCA TGTAGACAAA 
GTGATAATGA AACTGGGAAA GACAAATGCT AAAGCAGTTT CTGAAATGAG ACAGAAGATC 
TGGAATAATA TGCCGAAGGA TCATCCTGAT CATGAATTAA TTGACCCATT TCCGGTACCT 
CTGGTCATAA TTGGAAGTAA ATATGATGTT TTTCAGGATT TTGAGTCTGA GAAGAGAAAG 
GTAATATGCA AGACACTTCG ATTTGTTGCA CATTATTATG GAGCATCATT AATGTTTACC 
AGTAAATCAG AAGCTCTATT ACTAAAAATA CGTGGAGTTA TCAACCAGTT GGCATTTGGC 
ATTGACAAAA GCAAATCAAT ATGTGTGGAT CAGAATAAAC CGCTGTTTAT CACAGCAGGA 
TTGGATTCTT TCGGTCAAAT AGGATCTCCT CCTGTTCCTG AAAATGACAT TGGAAAGCTT 
CATGCCCACT CACCTATGGA GTTGTGGAAA AAAGTGTATG AAAAGCTCTT TCCACCAAAG 
AGTATTAACA CGCTGAAAGA TATCAAGGAC CCTGCGAGAG ATCCTCAGTA TGCTGAAAAT 
GAAGTCGATG AGATGAGAAT TCAGAAGGAT CTGGCACATC TAAGGAGATA TCCTATCAAG 
AAGCAGGACA AAACATCATG TGTTGCGGAT AACCAGGATT ATTTCCAAGG TGGGATAGCC 
TTTAAGAAGC CATTCCAATC TGTAGATGTG TGTACCTGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001335841.1
CDS	101..1222
Translation	MPSETLWEIAKAEVEKRGINGSEGDGAEIAEKFVFFIGSKNGGKTTIILRCLDRDEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSLVLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVFQDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLAFGIDKSKSICVDQNKPLFITAGLDSFGQIGSPPVPENDIGKLHAHSPMELWKKVYEKLFPPKSINTLKDIKDPARDPQYAENEVDEMRIQKDLAHLRRYPIKKQDKTSCVADNQDYFQGGIAFKKPFQSVDVCTC

Target ORF information:

RefSeq Version	NM_001348912.1
Organism	Homo sapiens(human)
Definition	Homo sapiens dynein cytoplasmic 2 light intermediate chain 1 (DYNC2LI1), transcript variant 5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001348912.1

ORF Insert Sequence:

ATGCCCAGTG AAACTCTCTG GGAAATTGCA AAAGCTGAAG TGGAAAAAAG GGGAATTAAT 
GGAAGTGAAG GTGATGGAGC TGAAATTGCA GAAAAATTTG TTTTCTTCAT TGGCAGTAAA 
AATGGGGGAA AGACTACTAT TATTCTAAGG TGTCTTGACA GAGATGAACC ACCAAAACCA 
ACCTTAGCTT TGGAATATAC ATATGGAAGA AGAGCAAAAG GGCACAACAC ACCAAAAGAT 
ATCGCTCACT TTTGGGAACT CGGTGGAGGA ACCTCTTTAT TGGACTTAAT CAGCATACCC 
ATCACAGGTG ACACCTTACG GACGTTTTCT CTTGTTCTCG TTCTGGATCT TTCAAAACCT 
AATGATCTCT GGCCCACCAT GGAAAATCTC TTGCAAGCCA CAAAAAGCCA TGTAGACAAA 
GTGATAATGA AACTGGGAAA GACAAATGCT AAAGCAGTTT CTGAAATGAG ACAGAAGATC 
TGGAATAATA TGCCGAAGGA TCATCCTGAT CATGAATTAA TTGACCCATT TCCGGTACCT 
CTGGTCATAA TTGGAAGTAA ATATGATGTT TTTCAGGATT TTGAGTCTGA GAAGAGAAAG 
GTAATATGCA AGACACTTCG ATTTGTTGCA CATTATTATG GAGCATCATT AATGTTTACC 
AGTAAATCAG AAGCTCTATT ACTAAAAATA CGTGGAGTTA TCAACCAGTT GGCATTTGGC 
ATTGACAAAA GCAAATCAAT ATGTGTGGAT CAGAATAAAC CGCTGTTTAT CACAGCAGGA 
TTGGATTCTT TCGGTCAAAT AGGATCTCCT CCTGTTCCTG AAAATGACAT TGGAAAGCTT 
CATGCCCACT CACCTATGGA GTTGTGGAAA AAAGTGTATG AAAAGCTCTT TCCACCAAAG 
AGTATTAACA CGCTGAAAGA TATCAAGGAC CCTGCGAGAG ATCCTCAGTA TGCTGAAAAT 
GAAGTCGATG AGATGAGAAT TCAGAAGGAT CTGGCACATC TAAGGAGATA TCCTATCAAG 
AAGCAGGACA AAACATCATG TGTTGCGGAT AACCAGGATT ATTTCCAAGG TGGGATAGCC 
TTTAAGAAGC CATTCCAATC TGTAGATGTG TGTACCTGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Biallelic mutations in DYNC2LI1 are a rare cause of Ellis-van Creveld syndrome.
Clinical genetics(2017 Aug)
Niceta M,Margiotti K,Digilio MC,Guida V,Bruselles A,Pizzi S,Ferraris A,Memo L,Laforgia N,Dentici ML,Consoli F,Torrente I,Ruiz-Perez VL,Dallapiccola B,Marino B,De Luca A,Tartaglia M

DYNC2LI1 mutations broaden the clinical spectrum of dynein-2 defects.
Scientific reports511649(2015 Jul)
Kessler K,Wunderlich I,Uebe S,Falk NS,Gie?l A,Brandst?tter JH,Popp B,Klinger P,Ekici AB,Sticht H,D?rr HG,Reis A,Roepman R,Seemanov? E,Thiel CT

Mutations in DYNC2LI1 disrupt cilia function and cause short rib polydactyly syndrome.
Nature communications67092(2015 Jun)
Taylor SP,Dantas TJ,Duran I,Wu S,Lachman RS,,Nelson SF,Cohn DH,Vallee RB,Krakow D

Recombinant human cytoplasmic dynein heavy chain 1 and 2: observation of dynein-2 motor activity in vitro.
FEBS letters585(15)2419-23(2011 Aug)
Ichikawa M,Watanabe Y,Murayama T,Toyoshima YY

BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins.
EMBO reports12(2)149-56(2011 Feb)
Gamerdinger M,Kaya AM,Wolfrum U,Clement AM,Behl C

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DYNC2LI1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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