Gene Symbol | TDP2 |
Entrez Gene ID | 51567 |
Full Name | tyrosyl-DNA phosphodiesterase 2 |
Synonyms | AD022,EAP2,EAPII,TTRAP,dJ30M3.3,hTDP2 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. [provided by RefSeq, Jul 2008]. |
Disorder MIM: | |
Disorder Html: | Spinocerebellar ataxia, autosomal recessive 23, 616949 (3) |