TRIAP1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TRIAP1
Entrez Gene ID	51499
Full Name	TP53 regulated inhibitor of apoptosis 1
Synonyms	HSPC132,MDM35,P53CSV,WF-1
General protein information	Preferred Names TP53 regulated inhibitor of apoptosis 1 Names TP53-regulated inhibitor of apoptosis 1 mitochondrial distribution and morphology 35 homolog p53-inducible cell-survival factor protein 15E1.1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q24.31
Disorder MIM:	614943

mRNA and Protein(s)

mRNA	Protein	Name
NM_016399.2	NP_057483.1	TP53-regulated inhibitor of apoptosis 1
NM_016399.3	NP_057483.1	TP53-regulated inhibitor of apoptosis 1

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	TRIAP1	NP_001264437.1
Danio rerio (zebrafish)	triap1	NP_001153292.2
Homo sapiens (human)	TRIAP1	NP_057483.1
Rattus norvegicus (Norway rat)	LOC100910137	XP_003751251.2
Xenopus tropicalis (tropical clawed frog)	triap1	NP_001016268.1
Pan troglodytes (chimpanzee)	TRIAP1	XP_001160868.1
Mus musculus (house mouse)	Triap1	NP_081209.1
Bos taurus (cattle)	TRIAP1	NP_001073244.1
Rattus norvegicus (Norway rat)	Triap1	NP_001119571.1
Canis lupus familiaris (dog)	TRIAP1	XP_546335.2

Gene Ontology
Bibliography

Related articles in PubMed

Overexpression of Mitochondria Mediator Gene TRIAP1 by miR-320b Loss Is Associated with Progression in Nasopharyngeal Carcinoma.
Li Y, Tang X, He Q, Yang X, Ren X, Wen X, Zhang J, Wang Y, Liu N, Ma J
PLoS genetics12(7)e1006183(2016 07)

TP53 Regulated Inhibitor of Apoptosis 1 (TRIAP1) stable silencing increases late apoptosis by upregulation of caspase 9 and APAF1 in RPMI8226 multiple myeloma cell line.
Fook-Alves VL, de Oliveira MB, Zanatta DB, Strauss BE, Colleoni GW
Biochimica et biophysica acta1862(6)1105-10(2016 Jun)

Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes.
Miliara X, Garnett JA, Tatsuta T, Abid Ali F, Baldie H, P?rez-Dorado I, Simpson P, Yague E, Langer T, Matthews S
EMBO reports16(7)824-35(2015 Jul)

Apoptosis inhibitor TRIAP1 is a novel effector of drug resistance.
Adams C, Cazzanelli G, Rasul S, Hitchinson B, Hu Y, Coombes RC, Raguz S, Yag?e E
Oncology reports34(1)415-22(2015 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TRIAP1 is regulated by miR-320b and has a role in progression in nasopharyngeal carcinoma
Title: Overexpression of Mitochondria Mediator Gene TRIAP1 by miR-320b Loss Is Associated with Progression in Nasopharyngeal Carcinoma.

crystal structures of free TRIAP1 and TRIAP1-SLMO1 complex reveal how the PRELI domain is chaperoned during import into the intermembrane mitochondrial space; structural resemblance of PRELI-like domain of SLMO1 with that of mammalian phoshatidylinositol transfer proteins suggest they share similar lipid transfer mechanisms
Title: Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes.

Results describe the upregulation of TRIAP1 in drugresistant breast cancer cells. Its experimental modulation changed breast tumor cells sensitivity to doxorubicin, thus confirming its role in drug resistance.
Title: Apoptosis inhibitor TRIAP1 is a novel effector of drug resistance.

Loss of TRIAP1 or PRELI impairs the accumulation of Cardiolipin, facilitates the release of cytochrome c, and renders cells vulnerable to apoptosis upon intrinsic and extrinsic stimulation.
Title: TRIAP1/PRELI complexes prevent apoptosis by mediating intramitochondrial transport of phosphatidic acid.

TRIAP1 is Conserved Specific Coregulators of the p21:PUMA Expression Ratio.
Title: A genetic screen identifies TCF3/E2A and TRIAP1 as pathway-specific regulators of the cellular response to p53 activation.

The following TRIAP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TRIAP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu15000	NM_016399.3 Latest version!	Homo sapiens TP53 regulated inhibitor of apoptosis 1 (TRIAP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu15000	NM_016399.2	Homo sapiens TP53 regulated inhibitor of apoptosis 1 (TRIAP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TRIAP1 ( NM_016399.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_057483.1 Homo sapiens TP53 regulated inhibitor of apoptosis 1 (TRIAP1), mRNA.

Price & Availability↑

CloneID	OHu15000
Clone ID Related Accession (Same CDS sequence)	NM_016399.2 , NM_016399.3
Accession Version	NM_016399.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 231bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	TP53-regulated inhibitor of apoptosis 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB141335.1 and U75688.1. On Dec 4, 2003 this sequence version replaced NM_016399.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.248657.1, BC002638.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGAACAGTG TGGGGGAGGC ATGCACGGAC ATGAAGCGCG AGTACGACCA GTGCTTCAAT 
CGCTGGTTCG CCGAGAAATT TCTCAAGGGG GACAGCTCCG GGGACCCGTG CACCGACCTC 
TTCAAGCGCT ACCAGCAGTG TGTTCAGAAA GCAATAAAGG AGAAAGAGAT TCCTATTGAA 
GGACTGGAGT TCATGGGCCA TGGCAAAGAA AAGCCTGAAA ATTCTTCTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057483.1
CDS	41..271
Translation	MNSVGEACTDMKREYDQCFNRWFAEKFLKGDSSGDPCTDLFKRYQQCVQKAIKEKEIPIEGLEFMGHGKEKPENSS

Target ORF information:

RefSeq Version	NM_016399.2
Organism	Homo sapiens(human)
Definition	Homo sapiens TP53 regulated inhibitor of apoptosis 1 (TRIAP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016399.2

ORF Insert Sequence:

ATGAACAGTG TGGGGGAGGC ATGCACGGAC ATGAAGCGCG AGTACGACCA GTGCTTCAAT 
CGCTGGTTCG CCGAGAAATT TCTCAAGGGG GACAGCTCCG GGGACCCGTG CACCGACCTC 
TTCAAGCGCT ACCAGCAGTG TGTTCAGAAA GCAATAAAGG AGAAAGAGAT TCCTATTGAA 
GGACTGGAGT TCATGGGCCA TGGCAAAGAA AAGCCTGAAA ATTCTTCTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TRIAP1 ( NM_016399.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057483.1 Homo sapiens TP53 regulated inhibitor of apoptosis 1 (TRIAP1), mRNA.

Price & Availability↑

CloneID	OHu15000
Clone ID Related Accession (Same CDS sequence)	NM_016399.2 , NM_016399.3
Accession Version	NM_016399.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 231bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Homo sapiens(human)
Product	TP53-regulated inhibitor of apoptosis 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB141335.1 and U75688.1. On Nov 22, 2018 this sequence version replaced NM_016399.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC002638.2, SRR5189664.88452.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000546954.2/ ENSP00000449795.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAACAGTG TGGGGGAGGC ATGCACGGAC ATGAAGCGCG AGTACGACCA GTGCTTCAAT 
CGCTGGTTCG CCGAGAAATT TCTCAAGGGG GACAGCTCCG GGGACCCGTG CACCGACCTC 
TTCAAGCGCT ACCAGCAGTG TGTTCAGAAA GCAATAAAGG AGAAAGAGAT TCCTATTGAA 
GGACTGGAGT TCATGGGCCA TGGCAAAGAA AAGCCTGAAA ATTCTTCTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057483.1
CDS	13..243
Translation	MNSVGEACTDMKREYDQCFNRWFAEKFLKGDSSGDPCTDLFKRYQQCVQKAIKEKEIPIEGLEFMGHGKEKPENSS

Target ORF information:

RefSeq Version	NM_016399.3
Organism	Homo sapiens(human)
Definition	Homo sapiens TP53 regulated inhibitor of apoptosis 1 (TRIAP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016399.3

ORF Insert Sequence:

ATGAACAGTG TGGGGGAGGC ATGCACGGAC ATGAAGCGCG AGTACGACCA GTGCTTCAAT 
CGCTGGTTCG CCGAGAAATT TCTCAAGGGG GACAGCTCCG GGGACCCGTG CACCGACCTC 
TTCAAGCGCT ACCAGCAGTG TGTTCAGAAA GCAATAAAGG AGAAAGAGAT TCCTATTGAA 
GGACTGGAGT TCATGGGCCA TGGCAAAGAA AAGCCTGAAA ATTCTTCTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Overexpression of Mitochondria Mediator Gene TRIAP1 by miR-320b Loss Is Associated with Progression in Nasopharyngeal Carcinoma.
PLoS genetics12(7)e1006183(2016 07)
Li Y,Tang X,He Q,Yang X,Ren X,Wen X,Zhang J,Wang Y,Liu N,Ma J

TP53 Regulated Inhibitor of Apoptosis 1 (TRIAP1) stable silencing increases late apoptosis by upregulation of caspase 9 and APAF1 in RPMI8226 multiple myeloma cell line.
Biochimica et biophysica acta1862(6)1105-10(2016 Jun)
Fook-Alves VL,de Oliveira MB,Zanatta DB,Strauss BE,Colleoni GW

Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes.
EMBO reports16(7)824-35(2015 Jul)
Miliara X,Garnett JA,Tatsuta T,Abid Ali F,Baldie H,P?rez-Dorado I,Simpson P,Yague E,Langer T,Matthews S

Apoptosis inhibitor TRIAP1 is a novel effector of drug resistance.
Oncology reports34(1)415-22(2015 Jul)
Adams C,Cazzanelli G,Rasul S,Hitchinson B,Hu Y,Coombes RC,Raguz S,Yag?e E

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TRIAP1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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