RTCB cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RTCB
Entrez Gene ID	51493
Full Name	RNA 2',3'-cyclic phosphate and 5'-OH ligase
Synonyms	C22orf28,DJ149A16.6,FAAP,HSPC117
General protein information	Preferred Names RNA 2',3'-cyclic phosphate and 5'-OH ligase Names tRNA-splicing ligase RtcB homolog ankyrin repeat domain 54 focal adhesion-associated protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q12.3
Disorder MIM:	613901

mRNA and Protein(s)

mRNA	Protein	Name
NM_014306.4	NP_055121.1	tRNA-splicing ligase RtcB homolog
NM_014306.5	NP_055121.1	tRNA-splicing ligase RtcB homolog

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	RTCB	XP_531754.2
Bos taurus (cattle)	RTCB	NP_001015631.1
Mus musculus (house mouse)	Rtcb	NP_663397.1
	C10H22orf28	XP_001112395.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008147	XP_317316.2
Danio rerio (zebrafish)	rtcb	NP_998268.1
Caenorhabditis elegans (roundworm)	F16A11.2	NP_492498.1
Homo sapiens (human)	RTCB	NP_055121.1
Pan troglodytes (chimpanzee)	C22H22orf28	XP_001152688.1
Rattus norvegicus (Norway rat)	Rtcb	NP_997497.1
Gallus gallus (chicken)	C22ORF28	XP_416300.2
Drosophila melanogaster (fruit fly)	CG9987	NP_609965.1
Xenopus tropicalis (tropical clawed frog)	rtcb	NP_001025674.1

Gene Ontology
Bibliography

Related articles in PubMed

Homology model of the human tRNA splicing ligase RtcB.
Nandy A, Saenz-M?ndez P, Gorman AM, Samali A, Eriksson LA
Proteins85(11)1983-1993(2017 Nov)

Phospho-tyrosine dependent protein-protein interaction network.
Grossmann A, Benlasfer N, Birth P, Hegele A, Wachsmuth F, Apelt L, Stelzl U
Molecular systems biology11(3)794(2015 Mar)

The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells.
Jurkin J, Henkel T, Nielsen AF, Minnich M, Popow J, Kaufmann T, Heindl K, Hoffmann T, Busslinger M, Martinez J
The EMBO journal33(24)2922-36(2014 Dec)

A synthetic biology approach identifies the mammalian UPR RNA ligase RtcB.
Lu Y, Liang FX, Wang X
Molecular cell55(5)758-70(2014 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This paper presents a homology model of human RtcB (hRtcB). The structure was analyzed in terms of stereochemical quality, folding reliability, secondary structure, druggability of the active site binding pocket and its metal-binding microenvironment.
Title: Homology model of the human tRNA splicing ligase RtcB.

RTCB, the catalytic subunit of the tRNA ligase complex, and its co-factor archease mediate XBP1 mRNA splicing both in vitro and in vivo.
Title: The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells.

Over-expression of HSPC117 mRNA reduced MMP 2 and MMP 14 mRNA expression, while TIMP 2 mRNA expression was up-regulated.
Title: HSPC117 is regulated by epigenetic modification and is involved in the migration of JEG-3 cells.

hCLE/C14orf166 associates with DDX1, HSPC117, and FAM98B in a novel transcription-dependent shuttling RNA-transporting complex.
Title: hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complex.

study identified HSPC117, a member of the UPF0027 (RtcB) family, as the essential subunit of a tRNA ligase complex; RNA interference-mediated depletion of HSPC117 inhibited maturation of intron-containing pre-tRNA both in vitro and in living cells
Title: HSPC117 is the essential subunit of a human tRNA splicing ligase complex.

The following RTCB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RTCB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24215	NM_014306.5 Latest version!	Homo sapiens RNA 2',3'-cyclic phosphate and 5'-OH ligase (RTCB), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu24215	NM_014306.4	Homo sapiens RNA 2',3'-cyclic phosphate and 5'-OH ligase (RTCB), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RTCB ( NM_014306.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055121.1 Homo sapiens RNA 2',3'-cyclic phosphate and 5'-OH ligase (RTCB), mRNA.

Price & Availability↑

CloneID	OHu24215
Clone ID Related Accession (Same CDS sequence)	NM_014306.4 , NM_014306.5
Accession Version	NM_014306.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1518bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-11
Organism	Homo sapiens(human)
Product	tRNA-splicing ligase RtcB homolog
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DC396330.1, AL050255.1 and BU615556.1. On May 10, 2008 this sequence version replaced NM_014306.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.4957.1, BC016707.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467144 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTCGCA GCTATAATGA TGAGCTGCAG TTCTTGGAGA AGATCAATAA AAACTGCTGG 
AGGATCAAGA AGGGCTTCGT GCCCAACATG CAGGTTGAAG GTGTTTTCTA TGTGAATGAT 
GCTCTGGAGA AATTGATGTT TGAGGAATTA AGGAATGCCT GTCGAGGTGG TGGTGTTGGT 
GGCTTCCTGC CAGCCATGAA ACAGATTGGC AATGTGGCAG CCCTGCCTGG AATTGTTCAT 
CGATCTATTG GGCTTCCTGA TGTCCATTCA GGATATGGGT TTGCTATTGG GAACATGGCA 
GCCTTTGATA TGAATGACCC TGAAGCAGTA GTATCCCCAG GTGGTGTCGG GTTTGACATC 
AACTGTGGTG TCCGCTTGCT AAGAACCAAT TTAGATGAAA GTGATGTCCA GCCTGTGAAG 
GAGCAACTTG CCCAAGCTAT GTTTGACCAC ATTCCTGTTG GGGTGGGGTC AAAAGGTGTC 
ATCCCAATGA ATGCCAAAGA CTTGGAGGAG GCCTTGGAGA TGGGGGTGGA CTGGTCCTTA 
AGAGAAGGGT ATGCCTGGGC TGAAGACAAG GAGCACTGCG AGGAGTACGG AAGGATGCTG 
CAGGCTGACC CCAATAAAGT TTCTGCAAGG GCGAAGAAAA GAGGCCTTCC TCAGTTGGGG 
ACCCTGGGAG CAGGCAACCA TTATGCAGAA ATCCAGGTTG TGGATGAGAT TTTCAATGAG 
TATGCTGCTA AAAAAATGGG CATCGACCAT AAGGGACAGG TGTGTGTGAT GATCCACAGT 
GGAAGCAGAG GCTTGGGCCA CCAAGTAGCC ACAGATGCGC TGGTAGCTAT GGAGAAGGCC 
ATGAAGAGAG ACAAGATTAT AGTCAATGAT CGGCAGTTGG CTTGTGCTCG AATCGCTTCC 
CCAGAGGGTC AAGACTATCT GAAGGGAATG GCAGCTGCTG GGAACTATGC CTGGGTCAAC 
CGCTCTTCCA TGACCTTCTT AACCCGTCAG GCTTTCGCCA AGGTCTTCAA CACAACCCCT 
GATGACTTGG ACCTACATGT GATCTATGAT GTTTCTCACA ACATTGCCAA AGTGGAGCAG 
CATGTGGTGG ACGGAAAGGA ACGGACACTG TTAGTACACA GGAAGGGATC CACCCGCGCT 
TTCCCTCCTC ACCATCCCCT CATTGCTGTT GATTACCAAC TCACTGGACA GCCAGTGCTC 
ATTGGTGGCA CCATGGGAAC CTGTAGTTAT GTTCTTACTG GCACTGAACA GGGCATGACT 
GAGACCTTTG GAACAACCTG TCATGGAGCG GGCCGTGCAT TGTCCCGAGC AAAATCTCGA 
CGTAATTTAG ATTTCCAGGA TGTCTTAGAC AAATTGGCAG ATATGGGAAT TGCGATCCGT 
GTTGCCTCAC CCAAACTGGT TATGGAAGAG GCTCCTGAGT CCTATAAGAA TGTGACAGAT 
GTGGTAAATA CCTGCCATGA TGCTGGAATC AGCAAGAAAG CCATTAAACT GAGACCAATT 
GCTGTGATCA AAGGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055121.1
CDS	132..1649
Translation	MSRSYNDELQFLEKINKNCWRIKKGFVPNMQVEGVFYVNDALEKLMFEELRNACRGGGVGGFLPAMKQIGNVAALPGIVHRSIGLPDVHSGYGFAIGNMAAFDMNDPEAVVSPGGVGFDINCGVRLLRTNLDESDVQPVKEQLAQAMFDHIPVGVGSKGVIPMNAKDLEEALEMGVDWSLREGYAWAEDKEHCEEYGRMLQADPNKVSARAKKRGLPQLGTLGAGNHYAEIQVVDEIFNEYAAKKMGIDHKGQVCVMIHSGSRGLGHQVATDALVAMEKAMKRDKIIVNDRQLACARIASPEGQDYLKGMAAAGNYAWVNRSSMTFLTRQAFAKVFNTTPDDLDLHVIYDVSHNIAKVEQHVVDGKERTLLVHRKGSTRAFPPHHPLIAVDYQLTGQPVLIGGTMGTCSYVLTGTEQGMTETFGTTCHGAGRALSRAKSRRNLDFQDVLDKLADMGIAIRVASPKLVMEEAPESYKNVTDVVNTCHDAGISKKAIKLRPIAVIKG

Target ORF information:

RefSeq Version	NM_014306.4
Organism	Homo sapiens(human)
Definition	Homo sapiens RNA 2',3'-cyclic phosphate and 5'-OH ligase (RTCB), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014306.4

ORF Insert Sequence:

ATGAGTCGCA GCTATAATGA TGAGCTGCAG TTCTTGGAGA AGATCAATAA AAACTGCTGG 
AGGATCAAGA AGGGCTTCGT GCCCAACATG CAGGTTGAAG GTGTTTTCTA TGTGAATGAT 
GCTCTGGAGA AATTGATGTT TGAGGAATTA AGGAATGCCT GTCGAGGTGG TGGTGTTGGT 
GGCTTCCTGC CAGCCATGAA ACAGATTGGC AATGTGGCAG CCCTGCCTGG AATTGTTCAT 
CGATCTATTG GGCTTCCTGA TGTCCATTCA GGATATGGGT TTGCTATTGG GAACATGGCA 
GCCTTTGATA TGAATGACCC TGAAGCAGTA GTATCCCCAG GTGGTGTCGG GTTTGACATC 
AACTGTGGTG TCCGCTTGCT AAGAACCAAT TTAGATGAAA GTGATGTCCA GCCTGTGAAG 
GAGCAACTTG CCCAAGCTAT GTTTGACCAC ATTCCTGTTG GGGTGGGGTC AAAAGGTGTC 
ATCCCAATGA ATGCCAAAGA CTTGGAGGAG GCCTTGGAGA TGGGGGTGGA CTGGTCCTTA 
AGAGAAGGGT ATGCCTGGGC TGAAGACAAG GAGCACTGCG AGGAGTACGG AAGGATGCTG 
CAGGCTGACC CCAATAAAGT TTCTGCAAGG GCGAAGAAAA GAGGCCTTCC TCAGTTGGGG 
ACCCTGGGAG CAGGCAACCA TTATGCAGAA ATCCAGGTTG TGGATGAGAT TTTCAATGAG 
TATGCTGCTA AAAAAATGGG CATCGACCAT AAGGGACAGG TGTGTGTGAT GATCCACAGT 
GGAAGCAGAG GCTTGGGCCA CCAAGTAGCC ACAGATGCGC TGGTAGCTAT GGAGAAGGCC 
ATGAAGAGAG ACAAGATTAT AGTCAATGAT CGGCAGTTGG CTTGTGCTCG AATCGCTTCC 
CCAGAGGGTC AAGACTATCT GAAGGGAATG GCAGCTGCTG GGAACTATGC CTGGGTCAAC 
CGCTCTTCCA TGACCTTCTT AACCCGTCAG GCTTTCGCCA AGGTCTTCAA CACAACCCCT 
GATGACTTGG ACCTACATGT GATCTATGAT GTTTCTCACA ACATTGCCAA AGTGGAGCAG 
CATGTGGTGG ACGGAAAGGA ACGGACACTG TTAGTACACA GGAAGGGATC CACCCGCGCT 
TTCCCTCCTC ACCATCCCCT CATTGCTGTT GATTACCAAC TCACTGGACA GCCAGTGCTC 
ATTGGTGGCA CCATGGGAAC CTGTAGTTAT GTTCTTACTG GCACTGAACA GGGCATGACT 
GAGACCTTTG GAACAACCTG TCATGGAGCG GGCCGTGCAT TGTCCCGAGC AAAATCTCGA 
CGTAATTTAG ATTTCCAGGA TGTCTTAGAC AAATTGGCAG ATATGGGAAT TGCGATCCGT 
GTTGCCTCAC CCAAACTGGT TATGGAAGAG GCTCCTGAGT CCTATAAGAA TGTGACAGAT 
GTGGTAAATA CCTGCCATGA TGCTGGAATC AGCAAGAAAG CCATTAAACT GAGACCAATT 
GCTGTGATCA AAGGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RTCB ( NM_014306.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_055121.1 Homo sapiens RNA 2',3'-cyclic phosphate and 5'-OH ligase (RTCB), mRNA.

Price & Availability↑

CloneID	OHu24215
Clone ID Related Accession (Same CDS sequence)	NM_014306.4 , NM_014306.5
Accession Version	NM_014306.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1518bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Homo sapiens(human)
Product	tRNA-splicing ligase RtcB homolog
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DC396330.1 and AL050255.1. On Nov 23, 2018 this sequence version replaced NM_014306.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC016707.1, SRR1803616.239874.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467144 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000216038.6/ ENSP00000216038.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGTCGCA GCTATAATGA TGAGCTGCAG TTCTTGGAGA AGATCAATAA AAACTGCTGG 
AGGATCAAGA AGGGCTTCGT GCCCAACATG CAGGTTGAAG GTGTTTTCTA TGTGAATGAT 
GCTCTGGAGA AATTGATGTT TGAGGAATTA AGGAATGCCT GTCGAGGTGG TGGTGTTGGT 
GGCTTCCTGC CAGCCATGAA ACAGATTGGC AATGTGGCAG CCCTGCCTGG AATTGTTCAT 
CGATCTATTG GGCTTCCTGA TGTCCATTCA GGATATGGGT TTGCTATTGG GAACATGGCA 
GCCTTTGATA TGAATGACCC TGAAGCAGTA GTATCCCCAG GTGGTGTCGG GTTTGACATC 
AACTGTGGTG TCCGCTTGCT AAGAACCAAT TTAGATGAAA GTGATGTCCA GCCTGTGAAG 
GAGCAACTTG CCCAAGCTAT GTTTGACCAC ATTCCTGTTG GGGTGGGGTC AAAAGGTGTC 
ATCCCAATGA ATGCCAAAGA CTTGGAGGAG GCCTTGGAGA TGGGGGTGGA CTGGTCCTTA 
AGAGAAGGGT ATGCCTGGGC TGAAGACAAG GAGCACTGCG AGGAGTACGG AAGGATGCTG 
CAGGCTGACC CCAATAAAGT TTCTGCAAGG GCGAAGAAAA GAGGCCTTCC TCAGTTGGGG 
ACCCTGGGAG CAGGCAACCA TTATGCAGAA ATCCAGGTTG TGGATGAGAT TTTCAATGAG 
TATGCTGCTA AAAAAATGGG CATCGACCAT AAGGGACAGG TGTGTGTGAT GATCCACAGT 
GGAAGCAGAG GCTTGGGCCA CCAAGTAGCC ACAGATGCGC TGGTAGCTAT GGAGAAGGCC 
ATGAAGAGAG ACAAGATTAT AGTCAATGAT CGGCAGTTGG CTTGTGCTCG AATCGCTTCC 
CCAGAGGGTC AAGACTATCT GAAGGGAATG GCAGCTGCTG GGAACTATGC CTGGGTCAAC 
CGCTCTTCCA TGACCTTCTT AACCCGTCAG GCTTTCGCCA AGGTCTTCAA CACAACCCCT 
GATGACTTGG ACCTACATGT GATCTATGAT GTTTCTCACA ACATTGCCAA AGTGGAGCAG 
CATGTGGTGG ACGGAAAGGA ACGGACACTG TTAGTACACA GGAAGGGATC CACCCGCGCT 
TTCCCTCCTC ACCATCCCCT CATTGCTGTT GATTACCAAC TCACTGGACA GCCAGTGCTC 
ATTGGTGGCA CCATGGGAAC CTGTAGTTAT GTTCTTACTG GCACTGAACA GGGCATGACT 
GAGACCTTTG GAACAACCTG TCATGGAGCG GGCCGTGCAT TGTCCCGAGC AAAATCTCGA 
CGTAATTTAG ATTTCCAGGA TGTCTTAGAC AAATTGGCAG ATATGGGAAT TGCGATCCGT 
GTTGCCTCAC CCAAACTGGT TATGGAAGAG GCTCCTGAGT CCTATAAGAA TGTGACAGAT 
GTGGTAAATA CCTGCCATGA TGCTGGAATC AGCAAGAAAG CCATTAAACT GAGACCAATT 
GCTGTGATCA AAGGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055121.1
CDS	92..1609
Translation	MSRSYNDELQFLEKINKNCWRIKKGFVPNMQVEGVFYVNDALEKLMFEELRNACRGGGVGGFLPAMKQIGNVAALPGIVHRSIGLPDVHSGYGFAIGNMAAFDMNDPEAVVSPGGVGFDINCGVRLLRTNLDESDVQPVKEQLAQAMFDHIPVGVGSKGVIPMNAKDLEEALEMGVDWSLREGYAWAEDKEHCEEYGRMLQADPNKVSARAKKRGLPQLGTLGAGNHYAEIQVVDEIFNEYAAKKMGIDHKGQVCVMIHSGSRGLGHQVATDALVAMEKAMKRDKIIVNDRQLACARIASPEGQDYLKGMAAAGNYAWVNRSSMTFLTRQAFAKVFNTTPDDLDLHVIYDVSHNIAKVEQHVVDGKERTLLVHRKGSTRAFPPHHPLIAVDYQLTGQPVLIGGTMGTCSYVLTGTEQGMTETFGTTCHGAGRALSRAKSRRNLDFQDVLDKLADMGIAIRVASPKLVMEEAPESYKNVTDVVNTCHDAGISKKAIKLRPIAVIKG

Target ORF information:

RefSeq Version	NM_014306.5
Organism	Homo sapiens(human)
Definition	Homo sapiens RNA 2',3'-cyclic phosphate and 5'-OH ligase (RTCB), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014306.5

ORF Insert Sequence:

ATGAGTCGCA GCTATAATGA TGAGCTGCAG TTCTTGGAGA AGATCAATAA AAACTGCTGG 
AGGATCAAGA AGGGCTTCGT GCCCAACATG CAGGTTGAAG GTGTTTTCTA TGTGAATGAT 
GCTCTGGAGA AATTGATGTT TGAGGAATTA AGGAATGCCT GTCGAGGTGG TGGTGTTGGT 
GGCTTCCTGC CAGCCATGAA ACAGATTGGC AATGTGGCAG CCCTGCCTGG AATTGTTCAT 
CGATCTATTG GGCTTCCTGA TGTCCATTCA GGATATGGGT TTGCTATTGG GAACATGGCA 
GCCTTTGATA TGAATGACCC TGAAGCAGTA GTATCCCCAG GTGGTGTCGG GTTTGACATC 
AACTGTGGTG TCCGCTTGCT AAGAACCAAT TTAGATGAAA GTGATGTCCA GCCTGTGAAG 
GAGCAACTTG CCCAAGCTAT GTTTGACCAC ATTCCTGTTG GGGTGGGGTC AAAAGGTGTC 
ATCCCAATGA ATGCCAAAGA CTTGGAGGAG GCCTTGGAGA TGGGGGTGGA CTGGTCCTTA 
AGAGAAGGGT ATGCCTGGGC TGAAGACAAG GAGCACTGCG AGGAGTACGG AAGGATGCTG 
CAGGCTGACC CCAATAAAGT TTCTGCAAGG GCGAAGAAAA GAGGCCTTCC TCAGTTGGGG 
ACCCTGGGAG CAGGCAACCA TTATGCAGAA ATCCAGGTTG TGGATGAGAT TTTCAATGAG 
TATGCTGCTA AAAAAATGGG CATCGACCAT AAGGGACAGG TGTGTGTGAT GATCCACAGT 
GGAAGCAGAG GCTTGGGCCA CCAAGTAGCC ACAGATGCGC TGGTAGCTAT GGAGAAGGCC 
ATGAAGAGAG ACAAGATTAT AGTCAATGAT CGGCAGTTGG CTTGTGCTCG AATCGCTTCC 
CCAGAGGGTC AAGACTATCT GAAGGGAATG GCAGCTGCTG GGAACTATGC CTGGGTCAAC 
CGCTCTTCCA TGACCTTCTT AACCCGTCAG GCTTTCGCCA AGGTCTTCAA CACAACCCCT 
GATGACTTGG ACCTACATGT GATCTATGAT GTTTCTCACA ACATTGCCAA AGTGGAGCAG 
CATGTGGTGG ACGGAAAGGA ACGGACACTG TTAGTACACA GGAAGGGATC CACCCGCGCT 
TTCCCTCCTC ACCATCCCCT CATTGCTGTT GATTACCAAC TCACTGGACA GCCAGTGCTC 
ATTGGTGGCA CCATGGGAAC CTGTAGTTAT GTTCTTACTG GCACTGAACA GGGCATGACT 
GAGACCTTTG GAACAACCTG TCATGGAGCG GGCCGTGCAT TGTCCCGAGC AAAATCTCGA 
CGTAATTTAG ATTTCCAGGA TGTCTTAGAC AAATTGGCAG ATATGGGAAT TGCGATCCGT 
GTTGCCTCAC CCAAACTGGT TATGGAAGAG GCTCCTGAGT CCTATAAGAA TGTGACAGAT 
GTGGTAAATA CCTGCCATGA TGCTGGAATC AGCAAGAAAG CCATTAAACT GAGACCAATT 
GCTGTGATCA AAGGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Homology model of the human tRNA splicing ligase RtcB.
Proteins85(11)1983-1993(2017 Nov)
Nandy A,Saenz-M?ndez P,Gorman AM,Samali A,Eriksson LA

Phospho-tyrosine dependent protein-protein interaction network.
Molecular systems biology11(3)794(2015 Mar)
Grossmann A,Benlasfer N,Birth P,Hegele A,Wachsmuth F,Apelt L,Stelzl U

The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells.
The EMBO journal33(24)2922-36(2014 Dec)
Jurkin J,Henkel T,Nielsen AF,Minnich M,Popow J,Kaufmann T,Heindl K,Hoffmann T,Busslinger M,Martinez J

A synthetic biology approach identifies the mammalian UPR RNA ligase RtcB.
Molecular cell55(5)758-70(2014 Sep)
Lu Y,Liang FX,Wang X

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RTCB cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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