HSD17B7 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HSD17B7
Entrez Gene ID	51478
Full Name	hydroxysteroid 17-beta dehydrogenase 7
Synonyms	PRAP,SDR37C1
General protein information	Preferred Names hydroxysteroid 17-beta dehydrogenase 7 Names 3-keto-steroid reductase 17 beta-hydroxysteroid dehydrogenase type VII 17-beta-HSD 7 17-beta-hydroxysteroid dehydrogenase 7 17beta hydroxysteroid dehydrogenase estradiol 17-beta-dehydrogenase 7 short chain dehydrogenase/reductase family 37C member 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q23.3
Summary	HSD17B7 encodes an enzyme that functions both as a 17-beta-hydroxysteroid dehydrogenase (EC 1.1.1.62) in the biosynthesis of sex steroids and as a 3-ketosteroid reductase (EC 1.1.1.270) in the biosynthesis of cholesterol (Marijanovic et al., 2003 [PubMed 12829805]).[supplied by OMIM, May 2010].
Disorder MIM:	606756

mRNA and Protein(s)

mRNA	Protein	Name
NM_001304512.1	NP_001291441.1	3-keto-steroid reductase isoform 2
NM_016371.3	NP_057455.1	3-keto-steroid reductase isoform 1
NM_001304513.1	NP_001291442.1	3-keto-steroid reductase isoform 3

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	HSD17B7	XP_001174381.1
Bos taurus (cattle)	HSD17B7	NP_001076844.1
Gallus gallus (chicken)	HSD17B7	NP_001264435.1
Danio rerio (zebrafish)	hsd17b7	NP_001070796.1
Kluyveromyces lactis	KLLA0F19756g	XP_455967.1
Homo sapiens (human)	HSD17B7	NP_057455.1
Rattus norvegicus (Norway rat)	Hsd17b7	NP_058931.1
Danio rerio (zebrafish)	LOC100332819	XP_002662523.1
Xenopus tropicalis (tropical clawed frog)	hsd17b7	NP_001016209.1
	LOC720399	XP_002801925.1
Canis lupus familiaris (dog)	HSD17B7	XP_851698.1
Mus musculus (house mouse)	Hsd17b7	NP_034606.3
Eremothecium gossypii	AGOS_AGR068W	NP_986733.1
Schizosaccharomyces pombe (fission yeast)	erg27	NP_595440.1
Saccharomyces cerevisiae (baker's yeast)	ERG27	NP_013201.1

Gene Ontology
Bibliography

Related articles in PubMed

Substrate inhibition of 17?-HSD1 in living cells and regulation of 17?-HSD7 by 17?-HSD1 knockdown.
Han H, Th?riault JF, Chen G, Lin SX
The Journal of steroid biochemistry and molecular biology17236-45(2017 09)

Inhibition of 17beta-hydroxysteroid dehydrogenase type 7 modulates breast cancer protein profile and enhances apoptosis by down-regulating GRP78.
Wang XQ, Aka JA, Li T, Xu D, Doillon CJ, Lin SX
The Journal of steroid biochemistry and molecular biology172188-197(2017 09)

Synergistic control of sex hormones by 17?-HSD type 7: a novel target for estrogen-dependent breast cancer.
Wang X, G?rard C, Th?riault JF, Poirier D, Doillon CJ, Lin SX
Journal of molecular cell biology7(6)568-79(2015 Dec)

Reductive 17beta-hydroxysteroid dehydrogenases which synthesize estradiol and inactivate dihydrotestosterone constitute major and concerted players in ER+ breast cancer cells.
Zhang CY, Wang WQ, Chen J, Lin SX
The Journal of steroid biochemistry and molecular biology15024-34(2015 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Substrate inhibition of 17beta-HSD1 in tumor epithelial cells and regulation of 17beta-HSD7 by 17beta-HSD1 knockdown has been demonstrated.
Title: Substrate inhibition of 17?-HSD1 in living cells and regulation of 17?-HSD7 by 17?-HSD1 knockdown.

Inhibition of 17beta-HSD 7 modulates breast cancer protein profile and enhances apoptosis by down-regulating GRP78.
Title: Inhibition of 17beta-hydroxysteroid dehydrogenase type 7 modulates breast cancer protein profile and enhances apoptosis by down-regulating GRP78.

the dual functional 17beta-HSD7 is proposed as a novel target for estrogen-dependent breast cancer by regulating the balance of estradiol and dihydrotestosterone.
Title: Synergistic control of sex hormones by 17?-HSD type 7: a novel target for estrogen-dependent breast cancer.

17beta-HSD1 and 17beta-HSD7 are principal reductive 17beta-hydroxysteroid dehydrogenases and major players in the viability of estrogen-dependent breast cancer cells.
Title: Reductive 17beta-hydroxysteroid dehydrogenases which synthesize estradiol and inactivate dihydrotestosterone constitute major and concerted players in ER+ breast cancer cells.

17betaHSD7 is not the key enzyme responsible for androstenone and testosterone metabolism in porcine liver cells
Title: Investigation of testosterone, androstenone, and estradiol metabolism in HepG2 cells and primary culture pig hepatocytes and their effects on 17?HSD7 gene expression.

The following HSD17B7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HSD17B7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02222	NM_016371.3 Latest version!	Homo sapiens hydroxysteroid 17-beta dehydrogenase 7 (HSD17B7), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu67964	NM_001304512.1 Latest version!	Homo sapiens hydroxysteroid 17-beta dehydrogenase 7 (HSD17B7), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu67965	NM_001304513.1 Latest version!	Homo sapiens hydroxysteroid 17-beta dehydrogenase 7 (HSD17B7), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HSD17B7 ( NM_016371.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057455.1 Homo sapiens hydroxysteroid 17-beta dehydrogenase 7 (HSD17B7), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu02222
Clone ID Related Accession (Same CDS sequence)	NM_016371.3
Accession Version	NM_016371.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1026bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	3-keto-steroid reductase isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AU129437.1, BC007068.1 and BC065246.1. On Jan 29, 2015 this sequence version replaced NM_016371.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF145023.1, SRR1660803.180649.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCGAAAGG TGGTTTTGAT CACCGGGGCT AGCAGTGGCA TTGGCCTGGC CCTCTGCAAG 
CGGCTGCTGG CGGAAGATGA TGAGCTTCAT CTGTGTTTGG CGTGCAGGAA CATGAGCAAG 
GCAGAAGCTG TCTGTGCTGC TCTGCTGGCC TCTCACCCCA CTGCTGAGGT CACCATTGTC 
CAGGTGGATG TCAGCAACCT GCAGTCGGTC TTCCGGGCCT CCAAGGAACT TAAGCAAAGG 
TTTCAGAGAT TAGACTGTAT ATATCTAAAT GCTGGGATCA TGCCTAATCC ACAACTAAAT 
ATCAAAGCAC TTTTCTTTGG CCTCTTTTCA AGAAAAGTGA TTCATATGTT CTCCACAGCT 
GAAGGCCTGC TGACCCAGGG TGATAAGATC ACTGCTGATG GACTTCAGGA GGTGTTTGAG 
ACCAATGTCT TTGGCCATTT TATCCTGATT CGGGAACTGG AGCCTCTCCT CTGTCACAGT 
GACAATCCAT CTCAGCTCAT CTGGACATCA TCTCGCAGTG CAAGGAAATC TAATTTCAGC 
CTCGAGGACT TCCAGCACAG CAAAGGCAAG GAACCCTACA GCTCTTCCAA ATATGCCACT 
GACCTTTTGA GTGTGGCTTT GAACAGGAAC TTCAACCAGC AGGGTCTCTA TTCCAATGTG 
GCCTGTCCAG GTACAGCATT GACCAATTTG ACATATGGAA TTCTGCCTCC GTTTATATGG 
ACGCTGTTGA TGCCGGCAAT ATTGCTACTT CGCTTTTTTG CAAATGCATT CACTTTGACA 
CCATATAATG GAACAGAAGC TCTGGTATGG CTTTTCCACC AAAAGCCTGA ATCTCTCAAT 
CCTCTGATCA AATATCTGAG TGCCACCACT GGCTTTGGAA GAAATTACAT TATGACCCAG 
AAGATGGACC TAGATGAAGA CACTGCTGAA AAATTTTATC AAAAGTTACT GGAACTGGAA 
AAGCACATTA GGGTCACTAT TCAAAAAACA GATAATCAGG CCAGGCTCAG TGGCTCATGC 
CTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057455.1
CDS	100..1125
Translation	MRKVVLITGASSGIGLALCKRLLAEDDELHLCLACRNMSKAEAVCAALLASHPTAEVTIVQVDVSNLQSVFRASKELKQRFQRLDCIYLNAGIMPNPQLNIKALFFGLFSRKVIHMFSTAEGLLTQGDKITADGLQEVFETNVFGHFILIRELEPLLCHSDNPSQLIWTSSRSARKSNFSLEDFQHSKGKEPYSSSKYATDLLSVALNRNFNQQGLYSNVACPGTALTNLTYGILPPFIWTLLMPAILLLRFFANAFTLTPYNGTEALVWLFHQKPESLNPLIKYLSATTGFGRNYIMTQKMDLDEDTAEKFYQKLLELEKHIRVTIQKTDNQARLSGSCL

Target ORF information:

RefSeq Version	NM_016371.3
Organism	Homo sapiens(human)
Definition	Homo sapiens hydroxysteroid 17-beta dehydrogenase 7 (HSD17B7), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016371.3

ORF Insert Sequence:

ATGCGAAAGG TGGTTTTGAT CACCGGGGCT AGCAGTGGCA TTGGCCTGGC CCTCTGCAAG 
CGGCTGCTGG CGGAAGATGA TGAGCTTCAT CTGTGTTTGG CGTGCAGGAA CATGAGCAAG 
GCAGAAGCTG TCTGTGCTGC TCTGCTGGCC TCTCACCCCA CTGCTGAGGT CACCATTGTC 
CAGGTGGATG TCAGCAACCT GCAGTCGGTC TTCCGGGCCT CCAAGGAACT TAAGCAAAGG 
TTTCAGAGAT TAGACTGTAT ATATCTAAAT GCTGGGATCA TGCCTAATCC ACAACTAAAT 
ATCAAAGCAC TTTTCTTTGG CCTCTTTTCA AGAAAAGTGA TTCATATGTT CTCCACAGCT 
GAAGGCCTGC TGACCCAGGG TGATAAGATC ACTGCTGATG GACTTCAGGA GGTGTTTGAG 
ACCAATGTCT TTGGCCATTT TATCCTGATT CGGGAACTGG AGCCTCTCCT CTGTCACAGT 
GACAATCCAT CTCAGCTCAT CTGGACATCA TCTCGCAGTG CAAGGAAATC TAATTTCAGC 
CTCGAGGACT TCCAGCACAG CAAAGGCAAG GAACCCTACA GCTCTTCCAA ATATGCCACT 
GACCTTTTGA GTGTGGCTTT GAACAGGAAC TTCAACCAGC AGGGTCTCTA TTCCAATGTG 
GCCTGTCCAG GTACAGCATT GACCAATTTG ACATATGGAA TTCTGCCTCC GTTTATATGG 
ACGCTGTTGA TGCCGGCAAT ATTGCTACTT CGCTTTTTTG CAAATGCATT CACTTTGACA 
CCATATAATG GAACAGAAGC TCTGGTATGG CTTTTCCACC AAAAGCCTGA ATCTCTCAAT 
CCTCTGATCA AATATCTGAG TGCCACCACT GGCTTTGGAA GAAATTACAT TATGACCCAG 
AAGATGGACC TAGATGAAGA CACTGCTGAA AAATTTTATC AAAAGTTACT GGAACTGGAA 
AAGCACATTA GGGTCACTAT TCAAAAAACA GATAATCAGG CCAGGCTCAG TGGCTCATGC 
CTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HSD17B7 ( NM_001304512.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001291441.1 Homo sapiens hydroxysteroid 17-beta dehydrogenase 7 (HSD17B7), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu67964
Clone ID Related Accession (Same CDS sequence)	NM_001304512.1
Accession Version	NM_001304512.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 468bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	3-keto-steroid reductase isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AU129437.1, BC007068.1, DB256037.1 and AW136392.1. Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AU128567.1, SRR1803617.320656.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGAAAGG TGGTTTTGAT CACCGGGGCT AGCAGTGGCA TTGGCCTGGC CCTCTGCAAG 
CGGCTGCTGG CGGAAGATGA TGAGCTTCAT CTGTGTTTGG CGTGCAGGAA CATGAGCAAG 
GCAGAAGCTG TCTGTGCTGC TCTGCTGGCC TCTCACCCCA CTGCTGAGGT CACCATTGTC 
CAGGTGGATG TCAGCAACCT GCAGTCGGTC TTCCGGGCCT CCAAGGAACT TAAGCAAAGG 
TTTCAGAGAT TAGACTGTAT ATATCTAAAT GCTGGGATCA TGCCTAATCC ACAACTAAAT 
ATCAAAGCAC TTTTCTTTGG CCTCTTTTCA AGAAAAGTGA TTCATATGTT CTCCACAGCT 
GAAGGCCTGC TGACCCAGGG TGATAAGATC ACTGCTGATG GACTTCAGGA GGTGTTTGAG 
ACCAATGTCT TTGGCCATTT TATCCTGGTA AAGAAGCTGT GGGCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001291441.1
CDS	100..567
Translation	MRKVVLITGASSGIGLALCKRLLAEDDELHLCLACRNMSKAEAVCAALLASHPTAEVTIVQVDVSNLQSVFRASKELKQRFQRLDCIYLNAGIMPNPQLNIKALFFGLFSRKVIHMFSTAEGLLTQGDKITADGLQEVFETNVFGHFILVKKLWA

Target ORF information:

RefSeq Version	NM_001304512.1
Organism	Homo sapiens(human)
Definition	Homo sapiens hydroxysteroid 17-beta dehydrogenase 7 (HSD17B7), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001304512.1

ORF Insert Sequence:

ATGCGAAAGG TGGTTTTGAT CACCGGGGCT AGCAGTGGCA TTGGCCTGGC CCTCTGCAAG 
CGGCTGCTGG CGGAAGATGA TGAGCTTCAT CTGTGTTTGG CGTGCAGGAA CATGAGCAAG 
GCAGAAGCTG TCTGTGCTGC TCTGCTGGCC TCTCACCCCA CTGCTGAGGT CACCATTGTC 
CAGGTGGATG TCAGCAACCT GCAGTCGGTC TTCCGGGCCT CCAAGGAACT TAAGCAAAGG 
TTTCAGAGAT TAGACTGTAT ATATCTAAAT GCTGGGATCA TGCCTAATCC ACAACTAAAT 
ATCAAAGCAC TTTTCTTTGG CCTCTTTTCA AGAAAAGTGA TTCATATGTT CTCCACAGCT 
GAAGGCCTGC TGACCCAGGG TGATAAGATC ACTGCTGATG GACTTCAGGA GGTGTTTGAG 
ACCAATGTCT TTGGCCATTT TATCCTGGTA AAGAAGCTGT GGGCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HSD17B7 ( NM_001304513.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001291442.1 Homo sapiens hydroxysteroid 17-beta dehydrogenase 7 (HSD17B7), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu67965
Clone ID Related Accession (Same CDS sequence)	NM_001304513.1
Accession Version	NM_001304513.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 336bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	3-keto-steroid reductase isoform 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AU129437.1, BC007068.1 and AW136392.1. Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DB134300.1, SRR1660807.346946.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGAAAGG TGGTTTTGAT CACCGGGGCT AGCAGTGGCA TTGGCCTGGC CCTCTGCAAG 
CGGCTGCTGG CGGAAGATGA TGAGCTTCAT CTGTGTTTGG CGTGCAGGAA CATGAGCAAG 
GCAGAAGCTG TCTGTGCTGC TCTGCTGGCC TCTCACCCCA CTGCTGAGGT CACCATTGTC 
CAGGTGGATG TCAGCAACCT GCAGTCGGTC TTCCGGGCCT CCAAGGAACT TAAGCAAAGG 
TTTCAGAGAT TAGACTGTAT ATATCTAAAT GCTGGGATCA TGCCTAATCC ACAACTAAAT 
ATCAAAGCAC TTTTCTTTGG CCTCTTTTCA AGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001291442.1
CDS	100..435
Translation	MRKVVLITGASSGIGLALCKRLLAEDDELHLCLACRNMSKAEAVCAALLASHPTAEVTIVQVDVSNLQSVFRASKELKQRFQRLDCIYLNAGIMPNPQLNIKALFFGLFSS

Target ORF information:

RefSeq Version	NM_001304513.1
Organism	Homo sapiens(human)
Definition	Homo sapiens hydroxysteroid 17-beta dehydrogenase 7 (HSD17B7), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001304513.1

ORF Insert Sequence:

ATGCGAAAGG TGGTTTTGAT CACCGGGGCT AGCAGTGGCA TTGGCCTGGC CCTCTGCAAG 
CGGCTGCTGG CGGAAGATGA TGAGCTTCAT CTGTGTTTGG CGTGCAGGAA CATGAGCAAG 
GCAGAAGCTG TCTGTGCTGC TCTGCTGGCC TCTCACCCCA CTGCTGAGGT CACCATTGTC 
CAGGTGGATG TCAGCAACCT GCAGTCGGTC TTCCGGGCCT CCAAGGAACT TAAGCAAAGG 
TTTCAGAGAT TAGACTGTAT ATATCTAAAT GCTGGGATCA TGCCTAATCC ACAACTAAAT 
ATCAAAGCAC TTTTCTTTGG CCTCTTTTCA AGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Substrate inhibition of 17?-HSD1 in living cells and regulation of 17?-HSD7 by 17?-HSD1 knockdown.
The Journal of steroid biochemistry and molecular biology17236-45(2017 09)
Han H,Th?riault JF,Chen G,Lin SX

Inhibition of 17beta-hydroxysteroid dehydrogenase type 7 modulates breast cancer protein profile and enhances apoptosis by down-regulating GRP78.
The Journal of steroid biochemistry and molecular biology172188-197(2017 09)
Wang XQ,Aka JA,Li T,Xu D,Doillon CJ,Lin SX

Synergistic control of sex hormones by 17?-HSD type 7: a novel target for estrogen-dependent breast cancer.
Journal of molecular cell biology7(6)568-79(2015 Dec)
Wang X,G?rard C,Th?riault JF,Poirier D,Doillon CJ,Lin SX

Reductive 17beta-hydroxysteroid dehydrogenases which synthesize estradiol and inactivate dihydrotestosterone constitute major and concerted players in ER+ breast cancer cells.
The Journal of steroid biochemistry and molecular biology15024-34(2015 Jun)
Zhang CY,Wang WQ,Chen J,Lin SX

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HSD17B7 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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