DCDC2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DCDC2
Entrez Gene ID	51473
Full Name	doublecortin domain containing 2
Synonyms	DCDC2A,DFNB66,NPHP19,NSC,RU2,RU2S
General protein information	Preferred Names doublecortin domain containing 2 Names doublecortin domain-containing protein 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p22.3
Summary	This gene encodes a doublecortin domain-containing family member. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. This family member is thought to function in neuronal migration where it may affect the signaling of primary cilia. Mutations in this gene have been associated with reading disability (RD) type 2, also referred to as developmental dyslexia. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2013].
Disorder MIM:	605755
Disorder Html:	Nephronophthisis 19, 616217 (3); ?Deafness, autosomal recessive 66, 610212 (3); Sclerosing cholangitis, neonatal, 617394 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_016356.4	NP_057440.2	doublecortin domain-containing protein 2
NM_001195610.1	NP_001182539.1	doublecortin domain-containing protein 2
NM_016356.5	NP_057440.2	doublecortin domain-containing protein 2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Dcdc2a	NP_808245.2
Danio rerio (zebrafish)	dcdc2b	NP_001032778.1
Homo sapiens (human)	DCDC2	NP_057440.2
Xenopus tropicalis (tropical clawed frog)	dcdc2	XP_004915336.1
	DCDC2	XP_001100219.1
Canis lupus familiaris (dog)	DCDC2	XP_853515.2
Rattus norvegicus (Norway rat)	Dcdc2	NP_001099580.2
Gallus gallus (chicken)	DCDC2	XP_003640800.2
Bos taurus (cattle)	DCDC2	XP_002697586.1

Gene Ontology
Bibliography

Related articles in PubMed

The role of READ1 and KIAA0319 genetic variations in developmental dyslexia: testing main and interactive effects.
Trezzi V, Forni D, Giorda R, Villa M, Molteni M, Marino C, Mascheretti S
Journal of human genetics62(11)949-955(2017 Nov)

Complex effects of dyslexia risk factors account for ADHD traits: evidence from two independent samples.
Mascheretti S, Trezzi V, Giorda R, Boivin M, Plourde V, Vitaro F, Brendgen M, Dionne G, Marino C
Journal of child psychology and psychiatry, and allied disciplines58(1)75-82(2017 Jan)

Ciliary dyslexia candidate genes DYX1C1 and DCDC2 are regulated by Regulatory Factor X (RFX) transcription factors through X-box promoter motifs.
Tammimies K, Bieder A, Lauter G, Sugiaman-Trapman D, Torchet R, Hokkanen ME, Burghoorn J, Castr?n E, Kere J, Tapia-P?ez I, Swoboda P
FASEB journal : official publication of the Federation of American Societies for Experimental Biology30(10)3578-3587(2016 10)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Developmental dyslexia genetic (DCDC2) and environmental factors (smoke and miscarriage) underlie ADHD traits supporting a potential pleiotropic effect.
Title: Complex effects of dyslexia risk factors account for ADHD traits: evidence from two independent samples.

that endogenous DYX1C1 localizes to the base of the cilium, whereas DCDC2 localizes along the entire axoneme of the cilium
Title: Ciliary dyslexia candidate genes DYX1C1 and DCDC2 are regulated by Regulatory Factor X (RFX) transcription factors through X-box promoter motifs.

Study identified biallelic missense mutations or in-frame deletion in DCDC2 in children affected with neonatal sclerosi. Mutations involve highly conserved amino acids in the doublecortin domains of the protein. In cholangiocytes, DCDC2 protein is normally located in the cytoplasm and cilia, whereas in patients the mutated protein is accumulated in the cytoplasm, absent from cilia, and associated with ciliogenesis defect.
Title: DCDC2 Mutations Cause Neonatal Sclerosing Cholangitis.

DCDC2 Polymorphism is associated with reading disability.
Title: Association of DCDC2 Polymorphisms with Normal Variations in Reading Abilities in a Chinese Population.

off-target, non-immune mediated effects of the mTOR-inhibitor everolimus on the podocyte cytoskeleton might involve regulation of microtubules, revealing a potential novel role of TUBB2B and DCDC2 in glomerular podocyte development
Title: Everolimus Stabilizes Podocyte Microtubules via Enhancing TUBB2B and DCDC2 Expression.

The following DCDC2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DCDC2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20617	NM_001195610.1 Latest version!	Homo sapiens doublecortin domain containing 2 (DCDC2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu20617	NM_016356.5 Latest version!	Homo sapiens doublecortin domain containing 2 (DCDC2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu20617	NM_016356.4	Homo sapiens doublecortin domain containing 2 (DCDC2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DCDC2 ( NM_016356.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057440.2 Homo sapiens doublecortin domain containing 2 (DCDC2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu20617
Clone ID Related Accession (Same CDS sequence)	NM_016356.4 , NM_001195610.1 , NM_016356.5
Accession Version	NM_016356.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1431bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-12
Organism	Homo sapiens(human)
Product	doublecortin domain-containing protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF181721.1, AL359389.15, FO393410.1 and AI858903.1. This sequence is a reference standard in the RefSeqGene project. On Jan 15, 2013 this sequence version replaced NM_016356.3. Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF181721.1, AB032980.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968189, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCGGCA GCAGCGCCAG GTCCAGCCAC CTGTCTCAGC CCGTCGTGAA GAGCGTGCTT 
GTGTACCGCA ACGGGGACCC CTTCTACGCG GGGCGCCGCG TCGTCATCCA TGAGAAGAAG 
GTGTCCAGCT TCGAAGTCTT CCTGAAGGAG GTGACCGGCG GCGTTCAGGC ACCCTTTGGG 
GCCGTCAGGA ACATCTACAC CCCGCGGACT GGCCACCGAA TCCGGAAGCT AGACCAGATC 
CAGAGCGGGG GCAATTACGT GGCTGGAGGC CAGGAAGCCT TCAAGAAACT CAATTACTTG 
GACATAGGAG AAATCAAGAA AAGACCAATG GAAGTTGTTA ATACAGAGGT AAAACCAGTA 
ATCCATAGCA GGATCAACGT GTCAGCTCGC TTTAGAAAAC CGCTTCAGGA GCCGTGCACT 
ATCTTCTTGA TTGCAAATGG AGACCTCATA AACCCAGCTT CTCGCCTCCT TATCCCCAGA 
AAAACCTTGA ATCAGTGGGA TCATGTACTA CAAATGGTCA CAGAAAAAAT CACTCTGAGG 
AGCGGGGCTG TTCACAGGCT TTATACTTTA GAAGGAAAAC TTGTTGAGAG TGGAGCAGAG 
TTGGAGAATG GGCAGTTTTA TGTGGCTGTT GGCAGAGATA AGTTTAAGAA ACTGCCTTAC 
AGTGAGTTAC TTTTTGACAA GTCAACGATG AGAAGGCCTT TTGGTCAGAA AGCTTCTTCA 
CTACCTCCTA TTGTAGGATC CAGAAAGTCT AAAGGGAGTG GAAATGATCG CCACTCTAAG 
TCAACAGTTG GATCCAGTGA CAACTCATCT CCTCAGCCCC TGAAGAGGAA AGGGAAAAAA 
GAAGACGTGA ATTCAGAAAA ACTGACGAAA TTGAAACAAA ATGTAAAATT AAAGAATTCA 
CAAGAAACCA TTCCAAATAG TGATGAAGGC ATTTTCAAAG CTGGAGCAGA GAGGTCTGAA 
ACACGGGGGG CAGCAGAAGT CCAAGAAGAT GAAGATACTC AGGTTGAGGT TCCAGTCGAT 
CAGAGGCCAG CAGAAATAGT AGACGAGGAA GAAGATGGAG AGAAGGCAAA CAAGGATGCA 
GAACAGAAAG AAGACTTTTC AGGAATGAAT GGTGACCTTG AAGAGGAAGG AGGTAGGGAG 
GCTACAGATG CCCCTGAGCA AGTCGAGGAG ATTCTGGATC ACAGTGAGCA GCAGGCACGC 
CCTGCTCGTG TAAATGGAGG CACCGATGAG GAGAATGGTG AGGAGCTGCA GCAGGTTAAT 
AATGAGCTTC AACTGGTCCT AGACAAGGAA AGAAAGTCTC AAGGAGCTGG CAGTGGACAA 
GATGAGGCTG ATGTAGACCC TCAAAGACCA CCAAGGCCAG AAGTAAAAAT TACCAGTCCA 
GAAGAAAATG AAAACAACCA ACAAAACAAG GACTATGCTG CCGTGGCTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057440.2
CDS	303..1733
Translation	MSGSSARSSHLSQPVVKSVLVYRNGDPFYAGRRVVIHEKKVSSFEVFLKEVTGGVQAPFGAVRNIYTPRTGHRIRKLDQIQSGGNYVAGGQEAFKKLNYLDIGEIKKRPMEVVNTEVKPVIHSRINVSARFRKPLQEPCTIFLIANGDLINPASRLLIPRKTLNQWDHVLQMVTEKITLRSGAVHRLYTLEGKLVESGAELENGQFYVAVGRDKFKKLPYSELLFDKSTMRRPFGQKASSLPPIVGSRKSKGSGNDRHSKSTVGSSDNSSPQPLKRKGKKEDVNSEKLTKLKQNVKLKNSQETIPNSDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEKANKDAEQKEDFSGMNGDLEEEGGREATDAPEQVEEILDHSEQQARPARVNGGTDEENGEELQQVNNELQLVLDKERKSQGAGSGQDEADVDPQRPPRPEVKITSPEENENNQQNKDYAAVA

Target ORF information:

RefSeq Version	NM_016356.4
Organism	Homo sapiens(human)
Definition	Homo sapiens doublecortin domain containing 2 (DCDC2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016356.4

ORF Insert Sequence:

ATGAGCGGCA GCAGCGCCAG GTCCAGCCAC CTGTCTCAGC CCGTCGTGAA GAGCGTGCTT 
GTGTACCGCA ACGGGGACCC CTTCTACGCG GGGCGCCGCG TCGTCATCCA TGAGAAGAAG 
GTGTCCAGCT TCGAAGTCTT CCTGAAGGAG GTGACCGGCG GCGTTCAGGC ACCCTTTGGG 
GCCGTCAGGA ACATCTACAC CCCGCGGACT GGCCACCGAA TCCGGAAGCT AGACCAGATC 
CAGAGCGGGG GCAATTACGT GGCTGGAGGC CAGGAAGCCT TCAAGAAACT CAATTACTTG 
GACATAGGAG AAATCAAGAA AAGACCAATG GAAGTTGTTA ATACAGAGGT AAAACCAGTA 
ATCCATAGCA GGATCAACGT GTCAGCTCGC TTTAGAAAAC CGCTTCAGGA GCCGTGCACT 
ATCTTCTTGA TTGCAAATGG AGACCTCATA AACCCAGCTT CTCGCCTCCT TATCCCCAGA 
AAAACCTTGA ATCAGTGGGA TCATGTACTA CAAATGGTCA CAGAAAAAAT CACTCTGAGG 
AGCGGGGCTG TTCACAGGCT TTATACTTTA GAAGGAAAAC TTGTTGAGAG TGGAGCAGAG 
TTGGAGAATG GGCAGTTTTA TGTGGCTGTT GGCAGAGATA AGTTTAAGAA ACTGCCTTAC 
AGTGAGTTAC TTTTTGACAA GTCAACGATG AGAAGGCCTT TTGGTCAGAA AGCTTCTTCA 
CTACCTCCTA TTGTAGGATC CAGAAAGTCT AAAGGGAGTG GAAATGATCG CCACTCTAAG 
TCAACAGTTG GATCCAGTGA CAACTCATCT CCTCAGCCCC TGAAGAGGAA AGGGAAAAAA 
GAAGACGTGA ATTCAGAAAA ACTGACGAAA TTGAAACAAA ATGTAAAATT AAAGAATTCA 
CAAGAAACCA TTCCAAATAG TGATGAAGGC ATTTTCAAAG CTGGAGCAGA GAGGTCTGAA 
ACACGGGGGG CAGCAGAAGT CCAAGAAGAT GAAGATACTC AGGTTGAGGT TCCAGTCGAT 
CAGAGGCCAG CAGAAATAGT AGACGAGGAA GAAGATGGAG AGAAGGCAAA CAAGGATGCA 
GAACAGAAAG AAGACTTTTC AGGAATGAAT GGTGACCTTG AAGAGGAAGG AGGTAGGGAG 
GCTACAGATG CCCCTGAGCA AGTCGAGGAG ATTCTGGATC ACAGTGAGCA GCAGGCACGC 
CCTGCTCGTG TAAATGGAGG CACCGATGAG GAGAATGGTG AGGAGCTGCA GCAGGTTAAT 
AATGAGCTTC AACTGGTCCT AGACAAGGAA AGAAAGTCTC AAGGAGCTGG CAGTGGACAA 
GATGAGGCTG ATGTAGACCC TCAAAGACCA CCAAGGCCAG AAGTAAAAAT TACCAGTCCA 
GAAGAAAATG AAAACAACCA ACAAAACAAG GACTATGCTG CCGTGGCTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DCDC2 ( NM_001195610.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001182539.1 Homo sapiens doublecortin domain containing 2 (DCDC2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu20617
Clone ID Related Accession (Same CDS sequence)	NM_016356.4 , NM_001195610.1 , NM_016356.5
Accession Version	NM_001195610.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1431bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Homo sapiens(human)
Product	doublecortin domain-containing protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL359713.25, BC050704.1, AB032980.2, AL359389.15, FO393410.1 and AI858903.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC050704.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968189, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCGGCA GCAGCGCCAG GTCCAGCCAC CTGTCTCAGC CCGTCGTGAA GAGCGTGCTT 
GTGTACCGCA ACGGGGACCC CTTCTACGCG GGGCGCCGCG TCGTCATCCA TGAGAAGAAG 
GTGTCCAGCT TCGAAGTCTT CCTGAAGGAG GTGACCGGCG GCGTTCAGGC ACCCTTTGGG 
GCCGTCAGGA ACATCTACAC CCCGCGGACT GGCCACCGAA TCCGGAAGCT AGACCAGATC 
CAGAGCGGGG GCAATTACGT GGCTGGAGGC CAGGAAGCCT TCAAGAAACT CAATTACTTG 
GACATAGGAG AAATCAAGAA AAGACCAATG GAAGTTGTTA ATACAGAGGT AAAACCAGTA 
ATCCATAGCA GGATCAACGT GTCAGCTCGC TTTAGAAAAC CGCTTCAGGA GCCGTGCACT 
ATCTTCTTGA TTGCAAATGG AGACCTCATA AACCCAGCTT CTCGCCTCCT TATCCCCAGA 
AAAACCTTGA ATCAGTGGGA TCATGTACTA CAAATGGTCA CAGAAAAAAT CACTCTGAGG 
AGCGGGGCTG TTCACAGGCT TTATACTTTA GAAGGAAAAC TTGTTGAGAG TGGAGCAGAG 
TTGGAGAATG GGCAGTTTTA TGTGGCTGTT GGCAGAGATA AGTTTAAGAA ACTGCCTTAC 
AGTGAGTTAC TTTTTGACAA GTCAACGATG AGAAGGCCTT TTGGTCAGAA AGCTTCTTCA 
CTACCTCCTA TTGTAGGATC CAGAAAGTCT AAAGGGAGTG GAAATGATCG CCACTCTAAG 
TCAACAGTTG GATCCAGTGA CAACTCATCT CCTCAGCCCC TGAAGAGGAA AGGGAAAAAA 
GAAGACGTGA ATTCAGAAAA ACTGACGAAA TTGAAACAAA ATGTAAAATT AAAGAATTCA 
CAAGAAACCA TTCCAAATAG TGATGAAGGC ATTTTCAAAG CTGGAGCAGA GAGGTCTGAA 
ACACGGGGGG CAGCAGAAGT CCAAGAAGAT GAAGATACTC AGGTTGAGGT TCCAGTCGAT 
CAGAGGCCAG CAGAAATAGT AGACGAGGAA GAAGATGGAG AGAAGGCAAA CAAGGATGCA 
GAACAGAAAG AAGACTTTTC AGGAATGAAT GGTGACCTTG AAGAGGAAGG AGGTAGGGAG 
GCTACAGATG CCCCTGAGCA AGTCGAGGAG ATTCTGGATC ACAGTGAGCA GCAGGCACGC 
CCTGCTCGTG TAAATGGAGG CACCGATGAG GAGAATGGTG AGGAGCTGCA GCAGGTTAAT 
AATGAGCTTC AACTGGTCCT AGACAAGGAA AGAAAGTCTC AAGGAGCTGG CAGTGGACAA 
GATGAGGCTG ATGTAGACCC TCAAAGACCA CCAAGGCCAG AAGTAAAAAT TACCAGTCCA 
GAAGAAAATG AAAACAACCA ACAAAACAAG GACTATGCTG CCGTGGCTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001182539.1
CDS	210..1640
Translation	MSGSSARSSHLSQPVVKSVLVYRNGDPFYAGRRVVIHEKKVSSFEVFLKEVTGGVQAPFGAVRNIYTPRTGHRIRKLDQIQSGGNYVAGGQEAFKKLNYLDIGEIKKRPMEVVNTEVKPVIHSRINVSARFRKPLQEPCTIFLIANGDLINPASRLLIPRKTLNQWDHVLQMVTEKITLRSGAVHRLYTLEGKLVESGAELENGQFYVAVGRDKFKKLPYSELLFDKSTMRRPFGQKASSLPPIVGSRKSKGSGNDRHSKSTVGSSDNSSPQPLKRKGKKEDVNSEKLTKLKQNVKLKNSQETIPNSDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEKANKDAEQKEDFSGMNGDLEEEGGREATDAPEQVEEILDHSEQQARPARVNGGTDEENGEELQQVNNELQLVLDKERKSQGAGSGQDEADVDPQRPPRPEVKITSPEENENNQQNKDYAAVA

Target ORF information:

RefSeq Version	NM_001195610.1
Organism	Homo sapiens(human)
Definition	Homo sapiens doublecortin domain containing 2 (DCDC2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001195610.1

ORF Insert Sequence:

ATGAGCGGCA GCAGCGCCAG GTCCAGCCAC CTGTCTCAGC CCGTCGTGAA GAGCGTGCTT 
GTGTACCGCA ACGGGGACCC CTTCTACGCG GGGCGCCGCG TCGTCATCCA TGAGAAGAAG 
GTGTCCAGCT TCGAAGTCTT CCTGAAGGAG GTGACCGGCG GCGTTCAGGC ACCCTTTGGG 
GCCGTCAGGA ACATCTACAC CCCGCGGACT GGCCACCGAA TCCGGAAGCT AGACCAGATC 
CAGAGCGGGG GCAATTACGT GGCTGGAGGC CAGGAAGCCT TCAAGAAACT CAATTACTTG 
GACATAGGAG AAATCAAGAA AAGACCAATG GAAGTTGTTA ATACAGAGGT AAAACCAGTA 
ATCCATAGCA GGATCAACGT GTCAGCTCGC TTTAGAAAAC CGCTTCAGGA GCCGTGCACT 
ATCTTCTTGA TTGCAAATGG AGACCTCATA AACCCAGCTT CTCGCCTCCT TATCCCCAGA 
AAAACCTTGA ATCAGTGGGA TCATGTACTA CAAATGGTCA CAGAAAAAAT CACTCTGAGG 
AGCGGGGCTG TTCACAGGCT TTATACTTTA GAAGGAAAAC TTGTTGAGAG TGGAGCAGAG 
TTGGAGAATG GGCAGTTTTA TGTGGCTGTT GGCAGAGATA AGTTTAAGAA ACTGCCTTAC 
AGTGAGTTAC TTTTTGACAA GTCAACGATG AGAAGGCCTT TTGGTCAGAA AGCTTCTTCA 
CTACCTCCTA TTGTAGGATC CAGAAAGTCT AAAGGGAGTG GAAATGATCG CCACTCTAAG 
TCAACAGTTG GATCCAGTGA CAACTCATCT CCTCAGCCCC TGAAGAGGAA AGGGAAAAAA 
GAAGACGTGA ATTCAGAAAA ACTGACGAAA TTGAAACAAA ATGTAAAATT AAAGAATTCA 
CAAGAAACCA TTCCAAATAG TGATGAAGGC ATTTTCAAAG CTGGAGCAGA GAGGTCTGAA 
ACACGGGGGG CAGCAGAAGT CCAAGAAGAT GAAGATACTC AGGTTGAGGT TCCAGTCGAT 
CAGAGGCCAG CAGAAATAGT AGACGAGGAA GAAGATGGAG AGAAGGCAAA CAAGGATGCA 
GAACAGAAAG AAGACTTTTC AGGAATGAAT GGTGACCTTG AAGAGGAAGG AGGTAGGGAG 
GCTACAGATG CCCCTGAGCA AGTCGAGGAG ATTCTGGATC ACAGTGAGCA GCAGGCACGC 
CCTGCTCGTG TAAATGGAGG CACCGATGAG GAGAATGGTG AGGAGCTGCA GCAGGTTAAT 
AATGAGCTTC AACTGGTCCT AGACAAGGAA AGAAAGTCTC AAGGAGCTGG CAGTGGACAA 
GATGAGGCTG ATGTAGACCC TCAAAGACCA CCAAGGCCAG AAGTAAAAAT TACCAGTCCA 
GAAGAAAATG AAAACAACCA ACAAAACAAG GACTATGCTG CCGTGGCTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DCDC2 ( NM_016356.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_057440.2 Homo sapiens doublecortin domain containing 2 (DCDC2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu20617
Clone ID Related Accession (Same CDS sequence)	NM_016356.4 , NM_001195610.1 , NM_016356.5
Accession Version	NM_016356.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1431bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	doublecortin domain-containing protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL359713.25, AF181721.1, AL359389.15, FO393410.1 and AI858903.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_016356.4. Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB032980.2, SRR1660809.221895.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000378454.8/ ENSP00000367715.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGCGGCA GCAGCGCCAG GTCCAGCCAC CTGTCTCAGC CCGTCGTGAA GAGCGTGCTT 
GTGTACCGCA ACGGGGACCC CTTCTACGCG GGGCGCCGCG TCGTCATCCA TGAGAAGAAG 
GTGTCCAGCT TCGAAGTCTT CCTGAAGGAG GTGACCGGCG GCGTTCAGGC ACCCTTTGGG 
GCCGTCAGGA ACATCTACAC CCCGCGGACT GGCCACCGAA TCCGGAAGCT AGACCAGATC 
CAGAGCGGGG GCAATTACGT GGCTGGAGGC CAGGAAGCCT TCAAGAAACT CAATTACTTG 
GACATAGGAG AAATCAAGAA AAGACCAATG GAAGTTGTTA ATACAGAGGT AAAACCAGTA 
ATCCATAGCA GGATCAACGT GTCAGCTCGC TTTAGAAAAC CGCTTCAGGA GCCGTGCACT 
ATCTTCTTGA TTGCAAATGG AGACCTCATA AACCCAGCTT CTCGCCTCCT TATCCCCAGA 
AAAACCTTGA ATCAGTGGGA TCATGTACTA CAAATGGTCA CAGAAAAAAT CACTCTGAGG 
AGCGGGGCTG TTCACAGGCT TTATACTTTA GAAGGAAAAC TTGTTGAGAG TGGAGCAGAG 
TTGGAGAATG GGCAGTTTTA TGTGGCTGTT GGCAGAGATA AGTTTAAGAA ACTGCCTTAC 
AGTGAGTTAC TTTTTGACAA GTCAACGATG AGAAGGCCTT TTGGTCAGAA AGCTTCTTCA 
CTACCTCCTA TTGTAGGATC CAGAAAGTCT AAAGGGAGTG GAAATGATCG CCACTCTAAG 
TCAACAGTTG GATCCAGTGA CAACTCATCT CCTCAGCCCC TGAAGAGGAA AGGGAAAAAA 
GAAGACGTGA ATTCAGAAAA ACTGACGAAA TTGAAACAAA ATGTAAAATT AAAGAATTCA 
CAAGAAACCA TTCCAAATAG TGATGAAGGC ATTTTCAAAG CTGGAGCAGA GAGGTCTGAA 
ACACGGGGGG CAGCAGAAGT CCAAGAAGAT GAAGATACTC AGGTTGAGGT TCCAGTCGAT 
CAGAGGCCAG CAGAAATAGT AGACGAGGAA GAAGATGGAG AGAAGGCAAA CAAGGATGCA 
GAACAGAAAG AAGACTTTTC AGGAATGAAT GGTGACCTTG AAGAGGAAGG AGGTAGGGAG 
GCTACAGATG CCCCTGAGCA AGTCGAGGAG ATTCTGGATC ACAGTGAGCA GCAGGCACGC 
CCTGCTCGTG TAAATGGAGG CACCGATGAG GAGAATGGTG AGGAGCTGCA GCAGGTTAAT 
AATGAGCTTC AACTGGTCCT AGACAAGGAA AGAAAGTCTC AAGGAGCTGG CAGTGGACAA 
GATGAGGCTG ATGTAGACCC TCAAAGACCA CCAAGGCCAG AAGTAAAAAT TACCAGTCCA 
GAAGAAAATG AAAACAACCA ACAAAACAAG GACTATGCTG CCGTGGCTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057440.2
CDS	310..1740
Translation	MSGSSARSSHLSQPVVKSVLVYRNGDPFYAGRRVVIHEKKVSSFEVFLKEVTGGVQAPFGAVRNIYTPRTGHRIRKLDQIQSGGNYVAGGQEAFKKLNYLDIGEIKKRPMEVVNTEVKPVIHSRINVSARFRKPLQEPCTIFLIANGDLINPASRLLIPRKTLNQWDHVLQMVTEKITLRSGAVHRLYTLEGKLVESGAELENGQFYVAVGRDKFKKLPYSELLFDKSTMRRPFGQKASSLPPIVGSRKSKGSGNDRHSKSTVGSSDNSSPQPLKRKGKKEDVNSEKLTKLKQNVKLKNSQETIPNSDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEKANKDAEQKEDFSGMNGDLEEEGGREATDAPEQVEEILDHSEQQARPARVNGGTDEENGEELQQVNNELQLVLDKERKSQGAGSGQDEADVDPQRPPRPEVKITSPEENENNQQNKDYAAVA

Target ORF information:

RefSeq Version	NM_016356.5
Organism	Homo sapiens(human)
Definition	Homo sapiens doublecortin domain containing 2 (DCDC2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016356.5

ORF Insert Sequence:

ATGAGCGGCA GCAGCGCCAG GTCCAGCCAC CTGTCTCAGC CCGTCGTGAA GAGCGTGCTT 
GTGTACCGCA ACGGGGACCC CTTCTACGCG GGGCGCCGCG TCGTCATCCA TGAGAAGAAG 
GTGTCCAGCT TCGAAGTCTT CCTGAAGGAG GTGACCGGCG GCGTTCAGGC ACCCTTTGGG 
GCCGTCAGGA ACATCTACAC CCCGCGGACT GGCCACCGAA TCCGGAAGCT AGACCAGATC 
CAGAGCGGGG GCAATTACGT GGCTGGAGGC CAGGAAGCCT TCAAGAAACT CAATTACTTG 
GACATAGGAG AAATCAAGAA AAGACCAATG GAAGTTGTTA ATACAGAGGT AAAACCAGTA 
ATCCATAGCA GGATCAACGT GTCAGCTCGC TTTAGAAAAC CGCTTCAGGA GCCGTGCACT 
ATCTTCTTGA TTGCAAATGG AGACCTCATA AACCCAGCTT CTCGCCTCCT TATCCCCAGA 
AAAACCTTGA ATCAGTGGGA TCATGTACTA CAAATGGTCA CAGAAAAAAT CACTCTGAGG 
AGCGGGGCTG TTCACAGGCT TTATACTTTA GAAGGAAAAC TTGTTGAGAG TGGAGCAGAG 
TTGGAGAATG GGCAGTTTTA TGTGGCTGTT GGCAGAGATA AGTTTAAGAA ACTGCCTTAC 
AGTGAGTTAC TTTTTGACAA GTCAACGATG AGAAGGCCTT TTGGTCAGAA AGCTTCTTCA 
CTACCTCCTA TTGTAGGATC CAGAAAGTCT AAAGGGAGTG GAAATGATCG CCACTCTAAG 
TCAACAGTTG GATCCAGTGA CAACTCATCT CCTCAGCCCC TGAAGAGGAA AGGGAAAAAA 
GAAGACGTGA ATTCAGAAAA ACTGACGAAA TTGAAACAAA ATGTAAAATT AAAGAATTCA 
CAAGAAACCA TTCCAAATAG TGATGAAGGC ATTTTCAAAG CTGGAGCAGA GAGGTCTGAA 
ACACGGGGGG CAGCAGAAGT CCAAGAAGAT GAAGATACTC AGGTTGAGGT TCCAGTCGAT 
CAGAGGCCAG CAGAAATAGT AGACGAGGAA GAAGATGGAG AGAAGGCAAA CAAGGATGCA 
GAACAGAAAG AAGACTTTTC AGGAATGAAT GGTGACCTTG AAGAGGAAGG AGGTAGGGAG 
GCTACAGATG CCCCTGAGCA AGTCGAGGAG ATTCTGGATC ACAGTGAGCA GCAGGCACGC 
CCTGCTCGTG TAAATGGAGG CACCGATGAG GAGAATGGTG AGGAGCTGCA GCAGGTTAAT 
AATGAGCTTC AACTGGTCCT AGACAAGGAA AGAAAGTCTC AAGGAGCTGG CAGTGGACAA 
GATGAGGCTG ATGTAGACCC TCAAAGACCA CCAAGGCCAG AAGTAAAAAT TACCAGTCCA 
GAAGAAAATG AAAACAACCA ACAAAACAAG GACTATGCTG CCGTGGCTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The role of READ1 and KIAA0319 genetic variations in developmental dyslexia: testing main and interactive effects.
Journal of human genetics62(11)949-955(2017 Nov)
Trezzi V,Forni D,Giorda R,Villa M,Molteni M,Marino C,Mascheretti S

Complex effects of dyslexia risk factors account for ADHD traits: evidence from two independent samples.
Journal of child psychology and psychiatry, and allied disciplines58(1)75-82(2017 Jan)
Mascheretti S,Trezzi V,Giorda R,Boivin M,Plourde V,Vitaro F,Brendgen M,Dionne G,Marino C

Ciliary dyslexia candidate genes DYX1C1 and DCDC2 are regulated by Regulatory Factor X (RFX) transcription factors through X-box promoter motifs.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology30(10)3578-3587(2016 10)
Tammimies K,Bieder A,Lauter G,Sugiaman-Trapman D,Torchet R,Hokkanen ME,Burghoorn J,Castr?n E,Kere J,Tapia-P?ez I,Swoboda P

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DCDC2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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