PDE6C cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PDE6C
Entrez Gene ID	5146
Full Name	phosphodiesterase 6C
Synonyms	ACHM5,COD4,PDEA2
General protein information	Preferred Names phosphodiesterase 6C Names cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' cGMP phosphodiesterase 6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q23.33
Summary	This gene encodes the alpha-prime subunit of cone phosphodiesterase, which is composed of a homodimer of two alpha-prime subunits and 3 smaller proteins of 11, 13, and 15 kDa. Mutations in this gene are associated with cone dystrophy type 4 (COD4). [provided by RefSeq, Mar 2010].
Disorder MIM:	600827
Disorder Html:	Cone dystrophy 4, 613093 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_006204.3	NP_006195.3	cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
NM_006204.4	NP_006195.3	cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
XM_017016322.1	XP_016871811.1	cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PDE6C	XP_543934.3
Rattus norvegicus (Norway rat)	Pde6c	NP_001101992.1
Xenopus tropicalis (tropical clawed frog)	pde6c	XP_002937230.1
Homo sapiens (human)	PDE6C	NP_006195.3
Danio rerio (zebrafish)	pde6c	NP_957165.1
Pan troglodytes (chimpanzee)	PDE6C	XP_001148438.1
	PDE6C	XP_001092604.1
Mus musculus (house mouse)	Pde6c	NP_291092.1
Gallus gallus (chicken)	PDE6C	NP_990317.1
Bos taurus (cattle)	PDE6C	NP_776844.1

Gene Ontology
Bibliography

Related articles in PubMed

Mechanisms of mutant PDE6 proteins underlying retinal diseases.
Gopalakrishna KN, Boyd K, Artemyev NO
Cellular signalling3774-80(2017 Sep)

Congenital Achromatopsia and Macular Atrophy Caused by a Novel Recessive PDE6C Mutation (p.E591K).
Katagiri S, Hayashi T, Yoshitake K, Sergeev Y, Akahori M, Furuno M, Nishino J, Ikeo K, Tsunoda K, Tsuneoka H, Iwata T
Ophthalmic genetics36(2)137-44(2015 Jun)

Exchange of Cone for Rod Phosphodiesterase 6 Catalytic Subunits in Rod Photoreceptors Mimics in Part Features of Light Adaptation.
Majumder A, Pahlberg J, Muradov H, Boyd KK, Sampath AP, Artemyev NO
The Journal of neuroscience : the official journal of the Society for Neuroscience35(24)9225-35(2015 Jun)

A genome-wide association meta-analysis of preschool internalizing problems.
Benke KS, Nivard MG, Velders FP, Walters RK, Pappa I, Scheet PA, Xiao X, Ehli EA, Palmer LJ, Whitehouse AJ, Verhulst FC, Jaddoe VW, Rivadeneira F, Groen-Blokhuis MM, van Beijsterveldt CE, Davies GE, Hudziak JJ, Lubke GH, Boomsma DI, Pennell CE, Tiemeier H, Middeldorp CM,
Journal of the American Academy of Child and Adolescent Psychiatry53(6)667-676.e7(2014 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A novel homozygous PDE6C mutation was identified as the cause of ACHM. In addition, we identified an OPN1SW mutation in the sibling with complete achromatopsia.
Title: Congenital Achromatopsia and Macular Atrophy Caused by a Novel Recessive PDE6C Mutation (p.E591K).

Expression of PDE6 in rod photoreceptors show that the cone PDE6 isoform is responsible for the difference in light adaptation between rods and cones.
Title: Exchange of Cone for Rod Phosphodiesterase 6 Catalytic Subunits in Rod Photoreceptors Mimics in Part Features of Light Adaptation.

The majority (n = 12) of patients were either homozygotes or compound heterozygotes for known achromatopsia alleles, two in CNGB3 (p.T383fsX and p.T296YfsX9) and three in CNGA3 (p.R283Q, p.R427C and p.L527R).
Title: Molecular genetics of achromatopsia in Newfoundland reveal genetic heterogeneity, founder effects and the first cases of Jalili syndrome in North America.

analysis of amino acid residues responsible for the selectivity of tadalafil binding to two closely related phosphodiesterases, PDE5 and PDE6
Title: Identification of amino acid residues responsible for the selectivity of tadalafil binding to two closely related phosphodiesterases, PDE5 and PDE6.

Missense mutations, nonsense mutations, splice mutations, and small deletions and insertions in the affected genes cause achromatopsia.
Title: Clinical utility gene card for: achromatopsia.

The following PDE6C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PDE6C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19079	NM_006204.4 Latest version!	Homo sapiens phosphodiesterase 6C (PDE6C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
OHu91461	XM_017016322.1 Latest version!	Homo sapiens phosphodiesterase 6C (PDE6C), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
View Old Accession Versions >>
OHu19079	NM_006204.3	Homo sapiens phosphodiesterase 6C (PDE6C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PDE6C ( NM_006204.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006195.3 Homo sapiens phosphodiesterase 6C (PDE6C), mRNA.

Price & Availability↑

CloneID	OHu19079
Clone ID Related Accession (Same CDS sequence)	NM_006204.3 , NM_006204.4
Accession Version	NM_006204.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2577bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-20
Organism	Homo sapiens(human)
Product	cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U31973.1, AL356214.20, BG206143.1 and BG220856.1. This sequence is a reference standard in the RefSeqGene project. On Sep 19, 2007 this sequence version replaced NM_006204.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U31973.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2154405, SAMN03267781 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGTGAGA TCAACCAAGT TGCCGTGGAG AAATACCTGG AGGAGAACCC TCAGTTTGCC 
AAGGAGTACT TTGACAGGAA GTTGCGGGTG GAGGTGCTGG GAGAAATCTT CAAGAACAGC 
CAGGTGCCAG TCCAGTCCAG CATGTCCTTC TCTGAGCTGA CCCAGGTGGA GGAGTCAGCC 
CTGTGCTTGG AGCTGCTGTG GACCGTGCAG GAGGAGGGGG GCACCCCAGA GCAGGGGGTT 
CACAGGGCCC TGCAGAGGCT GGCCCACCTG CTCCAGGCTG ACCGCTGCAG CATGTTCCTG 
TGCCGGTCCC GGAACGGCAT ACCTGAGGTG GCCTCTAGGT TGCTGGATGT CACCCCCACC 
TCCAAGTTTG AGGACAACCT GGTGGGCCCT GACAAAGAAG TTGTGTTTCC ATTGGACATT 
GGGATAGTGG GTTGGGCTGC TCACACGAAG AAAACTCATA ATGTCCCAGA TGTGAAAAAG 
AACAGCCATT TTTCTGACTT CATGGACAAG CAAACTGGGT ATGTCACTAA GAACCTGCTG 
GCAACCCCGA TCGTGGTGGG CAAGGAGGTT CTTGCTGTGA TCATGGCAGT TAACAAAGTA 
AATGCATCTG AATTTTCCAA ACAGGATGAA GAGGTCTTTT CCAAATACCT CAACTTTGTG 
TCTATCATCC TAAGGCTTCA TCACACCAGC TACATGTACA ATATTGAATC CCGAAGAAGC 
CAGATCCTTA TGTGGTCAGC CAATAAAGTA TTTGAAGAAC TCACAGATGT TGAGCGACAG 
TTTCACAAAG CGCTCTACAC GGTTAGATCA TATCTGAACT GTGAACGATA CTCCATTGGA 
CTGCTGGACA TGACCAAGGA GAAGGAATTC TACGATGAAT GGCCAATCAA GCTTGGAGAA 
GTAGAGCCTT ATAAAGGTCC AAAGACACCT GATGGCAGGG AAGTCAACTT TTATAAAATC 
ATTGATTACA TTTTACATGG AAAAGAAGAG ATCAAAGTGA TTCCGACGCC TCCTGCAGAC 
CACTGGACAC TCATTAGTGG GTTGCCAACA TATGTTGCTG AAAATGGATT TATCTGTAAC 
ATGATGAATG CCCCTGCGGA TGAATACTTC ACATTTCAGA AAGGACCTGT AGACGAAACT 
GGTTGGGTCA TTAAGAATGT TTTGTCCCTG CCTATTGTCA ACAAGAAAGA AGATATTGTG 
GGAGTGGCTA CATTTTACAA CAGGAAGGAT GGAAAACCTT TCGATGAGCA TGATGAATAC 
ATTACCGAGA CTCTCACACA ATTTCTTGGA TGGTCTCTTT TAAATACTGA CACCTACGAT 
AAGATGAATA AGCTAGAAAA CAGAAAGGAC ATTGCTCAGG AAATGCTCAT GAACCAAACC 
AAAGCCACTC CTGAAGAAAT TAAGTCCATT TTGAAATTTC AAGAGAAGTT AAATGTTGAT 
GTAATTGACG ACTGTGAAGA AAAACAACTT GTTGCAATTT TGAAAGAGGA CTTGCCAGAC 
CCACGCTCAG CAGAACTGTA CGAATTCCGC TTCAGTGACT TCCCCCTTAC AGAGCACGGA 
TTGATTAAAT GTGGAATACG ACTGTTTTTT GAAATAAATG TGGTGGAGAA ATTCAAAGTA 
CCTGTAGAGG TTCTTACCAG ATGGATGTAC ACTGTGAGGA AAGGGTACCG AGCTGTCACT 
TACCACAATT GGCGGCATGG GTTCAACGTG GGGCAGACCA TGTTTACTTT GCTGATGACA 
GGAAGATTAA AGAAGTACTA CACAGATCTC GAAGCCTTTG CCATGCTTGC TGCTGCTTTC 
TGCCATGATA TTGACCACAG AGGCACCAAT AATTTGTACC AGATGAAATC CACGTCTCCA 
TTAGCAAGAC TTCATGGTTC TTCTATTTTG GAGAGGCACC ACCTGGAGTA CAGTAAGACT 
CTGTTGCAGG ATGAGAGTTT AAACATCTTC CAGAACCTAA ATAAGCGGCA GTTTGAAACA 
GTTATTCATT TGTTCGAGGT CGCAATAATA GCAACTGACC TGGCTTTATA TTTCAAGAAG 
AGGACCATGT TTCAAAAAAT TGTTGATGCC TGTGAACAAA TGCAAACGGA AGAAGAAGCC 
ATCAAATATG TAACTGTTGA TCCAACCAAG AAAGAGATTA TCATGGCAAT GATGATGACG 
GCATGTGACT TGTCTGCTAT TACCAAGCCC TGGGAGGTGC AAAGTCAGGT AGCACTTATG 
GTTGCAAATG AATTTTGGGA ACAAGGAGAT CTGGAGAGAA CAGTGTTGCA GCAACAACCC 
ATTCCTATGA TGGACAGAAA CAAAAGAGAT GAATTACCTA AACTTCAAGT TGGATTTATT 
GATTTTGTTT GTACTTTTGT ATATAAGGAG TTCTCACGGT TTCACAAAGA AATCACACCT 
ATGCTGAGTG GTCTTCAGAA TAACAGAGTA GAATGGAAAT CACTAGCTGA TGAGTATGAT 
GCAAAGATGA AGGTCATTGA AGAGGAGGCA AAAAAGCAAG AAGGAGGAGC CGAAAAAGCT 
GCTGAAGATT CAGGAGGTGG TGATGACAAA AAGTCCAAAA CATGTTTAAT GTTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006195.3
CDS	139..2715
Translation	MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML

Target ORF information:

RefSeq Version	NM_006204.3
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphodiesterase 6C (PDE6C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006204.3

ORF Insert Sequence:

ATGGGTGAGA TCAACCAAGT TGCCGTGGAG AAATACCTGG AGGAGAACCC TCAGTTTGCC 
AAGGAGTACT TTGACAGGAA GTTGCGGGTG GAGGTGCTGG GAGAAATCTT CAAGAACAGC 
CAGGTGCCAG TCCAGTCCAG CATGTCCTTC TCTGAGCTGA CCCAGGTGGA GGAGTCAGCC 
CTGTGCTTGG AGCTGCTGTG GACCGTGCAG GAGGAGGGGG GCACCCCAGA GCAGGGGGTT 
CACAGGGCCC TGCAGAGGCT GGCCCACCTG CTCCAGGCTG ACCGCTGCAG CATGTTCCTG 
TGCCGGTCCC GGAACGGCAT ACCTGAGGTG GCCTCTAGGT TGCTGGATGT CACCCCCACC 
TCCAAGTTTG AGGACAACCT GGTGGGCCCT GACAAAGAAG TTGTGTTTCC ATTGGACATT 
GGGATAGTGG GTTGGGCTGC TCACACGAAG AAAACTCATA ATGTCCCAGA TGTGAAAAAG 
AACAGCCATT TTTCTGACTT CATGGACAAG CAAACTGGGT ATGTCACTAA GAACCTGCTG 
GCAACCCCGA TCGTGGTGGG CAAGGAGGTT CTTGCTGTGA TCATGGCAGT TAACAAAGTA 
AATGCATCTG AATTTTCCAA ACAGGATGAA GAGGTCTTTT CCAAATACCT CAACTTTGTG 
TCTATCATCC TAAGGCTTCA TCACACCAGC TACATGTACA ATATTGAATC CCGAAGAAGC 
CAGATCCTTA TGTGGTCAGC CAATAAAGTA TTTGAAGAAC TCACAGATGT TGAGCGACAG 
TTTCACAAAG CGCTCTACAC GGTTAGATCA TATCTGAACT GTGAACGATA CTCCATTGGA 
CTGCTGGACA TGACCAAGGA GAAGGAATTC TACGATGAAT GGCCAATCAA GCTTGGAGAA 
GTAGAGCCTT ATAAAGGTCC AAAGACACCT GATGGCAGGG AAGTCAACTT TTATAAAATC 
ATTGATTACA TTTTACATGG AAAAGAAGAG ATCAAAGTGA TTCCGACGCC TCCTGCAGAC 
CACTGGACAC TCATTAGTGG GTTGCCAACA TATGTTGCTG AAAATGGATT TATCTGTAAC 
ATGATGAATG CCCCTGCGGA TGAATACTTC ACATTTCAGA AAGGACCTGT AGACGAAACT 
GGTTGGGTCA TTAAGAATGT TTTGTCCCTG CCTATTGTCA ACAAGAAAGA AGATATTGTG 
GGAGTGGCTA CATTTTACAA CAGGAAGGAT GGAAAACCTT TCGATGAGCA TGATGAATAC 
ATTACCGAGA CTCTCACACA ATTTCTTGGA TGGTCTCTTT TAAATACTGA CACCTACGAT 
AAGATGAATA AGCTAGAAAA CAGAAAGGAC ATTGCTCAGG AAATGCTCAT GAACCAAACC 
AAAGCCACTC CTGAAGAAAT TAAGTCCATT TTGAAATTTC AAGAGAAGTT AAATGTTGAT 
GTAATTGACG ACTGTGAAGA AAAACAACTT GTTGCAATTT TGAAAGAGGA CTTGCCAGAC 
CCACGCTCAG CAGAACTGTA CGAATTCCGC TTCAGTGACT TCCCCCTTAC AGAGCACGGA 
TTGATTAAAT GTGGAATACG ACTGTTTTTT GAAATAAATG TGGTGGAGAA ATTCAAAGTA 
CCTGTAGAGG TTCTTACCAG ATGGATGTAC ACTGTGAGGA AAGGGTACCG AGCTGTCACT 
TACCACAATT GGCGGCATGG GTTCAACGTG GGGCAGACCA TGTTTACTTT GCTGATGACA 
GGAAGATTAA AGAAGTACTA CACAGATCTC GAAGCCTTTG CCATGCTTGC TGCTGCTTTC 
TGCCATGATA TTGACCACAG AGGCACCAAT AATTTGTACC AGATGAAATC CACGTCTCCA 
TTAGCAAGAC TTCATGGTTC TTCTATTTTG GAGAGGCACC ACCTGGAGTA CAGTAAGACT 
CTGTTGCAGG ATGAGAGTTT AAACATCTTC CAGAACCTAA ATAAGCGGCA GTTTGAAACA 
GTTATTCATT TGTTCGAGGT CGCAATAATA GCAACTGACC TGGCTTTATA TTTCAAGAAG 
AGGACCATGT TTCAAAAAAT TGTTGATGCC TGTGAACAAA TGCAAACGGA AGAAGAAGCC 
ATCAAATATG TAACTGTTGA TCCAACCAAG AAAGAGATTA TCATGGCAAT GATGATGACG 
GCATGTGACT TGTCTGCTAT TACCAAGCCC TGGGAGGTGC AAAGTCAGGT AGCACTTATG 
GTTGCAAATG AATTTTGGGA ACAAGGAGAT CTGGAGAGAA CAGTGTTGCA GCAACAACCC 
ATTCCTATGA TGGACAGAAA CAAAAGAGAT GAATTACCTA AACTTCAAGT TGGATTTATT 
GATTTTGTTT GTACTTTTGT ATATAAGGAG TTCTCACGGT TTCACAAAGA AATCACACCT 
ATGCTGAGTG GTCTTCAGAA TAACAGAGTA GAATGGAAAT CACTAGCTGA TGAGTATGAT 
GCAAAGATGA AGGTCATTGA AGAGGAGGCA AAAAAGCAAG AAGGAGGAGC CGAAAAAGCT 
GCTGAAGATT CAGGAGGTGG TGATGACAAA AAGTCCAAAA CATGTTTAAT GTTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PDE6C ( NM_006204.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006195.3 Homo sapiens phosphodiesterase 6C (PDE6C), mRNA.

Price & Availability↑

CloneID	OHu19079
Clone ID Related Accession (Same CDS sequence)	NM_006204.3 , NM_006204.4
Accession Version	NM_006204.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2577bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL356214.20, U31973.1, BG206143.1, BG220856.1 and AL157396.9. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_006204.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U31973.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2154405, SAMN03267781 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000371447.4/ ENSP00000360502.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGTGAGA TCAACCAAGT TGCCGTGGAG AAATACCTGG AGGAGAACCC TCAGTTTGCC 
AAGGAGTACT TTGACAGGAA GTTGCGGGTG GAGGTGCTGG GAGAAATCTT CAAGAACAGC 
CAGGTGCCAG TCCAGTCCAG CATGTCCTTC TCTGAGCTGA CCCAGGTGGA GGAGTCAGCC 
CTGTGCTTGG AGCTGCTGTG GACCGTGCAG GAGGAGGGGG GCACCCCAGA GCAGGGGGTT 
CACAGGGCCC TGCAGAGGCT GGCCCACCTG CTCCAGGCTG ACCGCTGCAG CATGTTCCTG 
TGCCGGTCCC GGAACGGCAT ACCTGAGGTG GCCTCTAGGT TGCTGGATGT CACCCCCACC 
TCCAAGTTTG AGGACAACCT GGTGGGCCCT GACAAAGAAG TTGTGTTTCC ATTGGACATT 
GGGATAGTGG GTTGGGCTGC TCACACGAAG AAAACTCATA ATGTCCCAGA TGTGAAAAAG 
AACAGCCATT TTTCTGACTT CATGGACAAG CAAACTGGGT ATGTCACTAA GAACCTGCTG 
GCAACCCCGA TCGTGGTGGG CAAGGAGGTT CTTGCTGTGA TCATGGCAGT TAACAAAGTA 
AATGCATCTG AATTTTCCAA ACAGGATGAA GAGGTCTTTT CCAAATACCT CAACTTTGTG 
TCTATCATCC TAAGGCTTCA TCACACCAGC TACATGTACA ATATTGAATC CCGAAGAAGC 
CAGATCCTTA TGTGGTCAGC CAATAAAGTA TTTGAAGAAC TCACAGATGT TGAGCGACAG 
TTTCACAAAG CGCTCTACAC GGTTAGATCA TATCTGAACT GTGAACGATA CTCCATTGGA 
CTGCTGGACA TGACCAAGGA GAAGGAATTC TACGATGAAT GGCCAATCAA GCTTGGAGAA 
GTAGAGCCTT ATAAAGGTCC AAAGACACCT GATGGCAGGG AAGTCAACTT TTATAAAATC 
ATTGATTACA TTTTACATGG AAAAGAAGAG ATCAAAGTGA TTCCGACGCC TCCTGCAGAC 
CACTGGACAC TCATTAGTGG GTTGCCAACA TATGTTGCTG AAAATGGATT TATCTGTAAC 
ATGATGAATG CCCCTGCGGA TGAATACTTC ACATTTCAGA AAGGACCTGT AGACGAAACT 
GGTTGGGTCA TTAAGAATGT TTTGTCCCTG CCTATTGTCA ACAAGAAAGA AGATATTGTG 
GGAGTGGCTA CATTTTACAA CAGGAAGGAT GGAAAACCTT TCGATGAGCA TGATGAATAC 
ATTACCGAGA CTCTCACACA ATTTCTTGGA TGGTCTCTTT TAAATACTGA CACCTACGAT 
AAGATGAATA AGCTAGAAAA CAGAAAGGAC ATTGCTCAGG AAATGCTCAT GAACCAAACC 
AAAGCCACTC CTGAAGAAAT TAAGTCCATT TTGAAATTTC AAGAGAAGTT AAATGTTGAT 
GTAATTGACG ACTGTGAAGA AAAACAACTT GTTGCAATTT TGAAAGAGGA CTTGCCAGAC 
CCACGCTCAG CAGAACTGTA CGAATTCCGC TTCAGTGACT TCCCCCTTAC AGAGCACGGA 
TTGATTAAAT GTGGAATACG ACTGTTTTTT GAAATAAATG TGGTGGAGAA ATTCAAAGTA 
CCTGTAGAGG TTCTTACCAG ATGGATGTAC ACTGTGAGGA AAGGGTACCG AGCTGTCACT 
TACCACAATT GGCGGCATGG GTTCAACGTG GGGCAGACCA TGTTTACTTT GCTGATGACA 
GGAAGATTAA AGAAGTACTA CACAGATCTC GAAGCCTTTG CCATGCTTGC TGCTGCTTTC 
TGCCATGATA TTGACCACAG AGGCACCAAT AATTTGTACC AGATGAAATC CACGTCTCCA 
TTAGCAAGAC TTCATGGTTC TTCTATTTTG GAGAGGCACC ACCTGGAGTA CAGTAAGACT 
CTGTTGCAGG ATGAGAGTTT AAACATCTTC CAGAACCTAA ATAAGCGGCA GTTTGAAACA 
GTTATTCATT TGTTCGAGGT CGCAATAATA GCAACTGACC TGGCTTTATA TTTCAAGAAG 
AGGACCATGT TTCAAAAAAT TGTTGATGCC TGTGAACAAA TGCAAACGGA AGAAGAAGCC 
ATCAAATATG TAACTGTTGA TCCAACCAAG AAAGAGATTA TCATGGCAAT GATGATGACG 
GCATGTGACT TGTCTGCTAT TACCAAGCCC TGGGAGGTGC AAAGTCAGGT AGCACTTATG 
GTTGCAAATG AATTTTGGGA ACAAGGAGAT CTGGAGAGAA CAGTGTTGCA GCAACAACCC 
ATTCCTATGA TGGACAGAAA CAAAAGAGAT GAATTACCTA AACTTCAAGT TGGATTTATT 
GATTTTGTTT GTACTTTTGT ATATAAGGAG TTCTCACGGT TTCACAAAGA AATCACACCT 
ATGCTGAGTG GTCTTCAGAA TAACAGAGTA GAATGGAAAT CACTAGCTGA TGAGTATGAT 
GCAAAGATGA AGGTCATTGA AGAGGAGGCA AAAAAGCAAG AAGGAGGAGC CGAAAAAGCT 
GCTGAAGATT CAGGAGGTGG TGATGACAAA AAGTCCAAAA CATGTTTAAT GTTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006195.3
CDS	190..2766
Translation	MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML

Target ORF information:

RefSeq Version	NM_006204.4
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphodiesterase 6C (PDE6C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006204.4

ORF Insert Sequence:

ATGGGTGAGA TCAACCAAGT TGCCGTGGAG AAATACCTGG AGGAGAACCC TCAGTTTGCC 
AAGGAGTACT TTGACAGGAA GTTGCGGGTG GAGGTGCTGG GAGAAATCTT CAAGAACAGC 
CAGGTGCCAG TCCAGTCCAG CATGTCCTTC TCTGAGCTGA CCCAGGTGGA GGAGTCAGCC 
CTGTGCTTGG AGCTGCTGTG GACCGTGCAG GAGGAGGGGG GCACCCCAGA GCAGGGGGTT 
CACAGGGCCC TGCAGAGGCT GGCCCACCTG CTCCAGGCTG ACCGCTGCAG CATGTTCCTG 
TGCCGGTCCC GGAACGGCAT ACCTGAGGTG GCCTCTAGGT TGCTGGATGT CACCCCCACC 
TCCAAGTTTG AGGACAACCT GGTGGGCCCT GACAAAGAAG TTGTGTTTCC ATTGGACATT 
GGGATAGTGG GTTGGGCTGC TCACACGAAG AAAACTCATA ATGTCCCAGA TGTGAAAAAG 
AACAGCCATT TTTCTGACTT CATGGACAAG CAAACTGGGT ATGTCACTAA GAACCTGCTG 
GCAACCCCGA TCGTGGTGGG CAAGGAGGTT CTTGCTGTGA TCATGGCAGT TAACAAAGTA 
AATGCATCTG AATTTTCCAA ACAGGATGAA GAGGTCTTTT CCAAATACCT CAACTTTGTG 
TCTATCATCC TAAGGCTTCA TCACACCAGC TACATGTACA ATATTGAATC CCGAAGAAGC 
CAGATCCTTA TGTGGTCAGC CAATAAAGTA TTTGAAGAAC TCACAGATGT TGAGCGACAG 
TTTCACAAAG CGCTCTACAC GGTTAGATCA TATCTGAACT GTGAACGATA CTCCATTGGA 
CTGCTGGACA TGACCAAGGA GAAGGAATTC TACGATGAAT GGCCAATCAA GCTTGGAGAA 
GTAGAGCCTT ATAAAGGTCC AAAGACACCT GATGGCAGGG AAGTCAACTT TTATAAAATC 
ATTGATTACA TTTTACATGG AAAAGAAGAG ATCAAAGTGA TTCCGACGCC TCCTGCAGAC 
CACTGGACAC TCATTAGTGG GTTGCCAACA TATGTTGCTG AAAATGGATT TATCTGTAAC 
ATGATGAATG CCCCTGCGGA TGAATACTTC ACATTTCAGA AAGGACCTGT AGACGAAACT 
GGTTGGGTCA TTAAGAATGT TTTGTCCCTG CCTATTGTCA ACAAGAAAGA AGATATTGTG 
GGAGTGGCTA CATTTTACAA CAGGAAGGAT GGAAAACCTT TCGATGAGCA TGATGAATAC 
ATTACCGAGA CTCTCACACA ATTTCTTGGA TGGTCTCTTT TAAATACTGA CACCTACGAT 
AAGATGAATA AGCTAGAAAA CAGAAAGGAC ATTGCTCAGG AAATGCTCAT GAACCAAACC 
AAAGCCACTC CTGAAGAAAT TAAGTCCATT TTGAAATTTC AAGAGAAGTT AAATGTTGAT 
GTAATTGACG ACTGTGAAGA AAAACAACTT GTTGCAATTT TGAAAGAGGA CTTGCCAGAC 
CCACGCTCAG CAGAACTGTA CGAATTCCGC TTCAGTGACT TCCCCCTTAC AGAGCACGGA 
TTGATTAAAT GTGGAATACG ACTGTTTTTT GAAATAAATG TGGTGGAGAA ATTCAAAGTA 
CCTGTAGAGG TTCTTACCAG ATGGATGTAC ACTGTGAGGA AAGGGTACCG AGCTGTCACT 
TACCACAATT GGCGGCATGG GTTCAACGTG GGGCAGACCA TGTTTACTTT GCTGATGACA 
GGAAGATTAA AGAAGTACTA CACAGATCTC GAAGCCTTTG CCATGCTTGC TGCTGCTTTC 
TGCCATGATA TTGACCACAG AGGCACCAAT AATTTGTACC AGATGAAATC CACGTCTCCA 
TTAGCAAGAC TTCATGGTTC TTCTATTTTG GAGAGGCACC ACCTGGAGTA CAGTAAGACT 
CTGTTGCAGG ATGAGAGTTT AAACATCTTC CAGAACCTAA ATAAGCGGCA GTTTGAAACA 
GTTATTCATT TGTTCGAGGT CGCAATAATA GCAACTGACC TGGCTTTATA TTTCAAGAAG 
AGGACCATGT TTCAAAAAAT TGTTGATGCC TGTGAACAAA TGCAAACGGA AGAAGAAGCC 
ATCAAATATG TAACTGTTGA TCCAACCAAG AAAGAGATTA TCATGGCAAT GATGATGACG 
GCATGTGACT TGTCTGCTAT TACCAAGCCC TGGGAGGTGC AAAGTCAGGT AGCACTTATG 
GTTGCAAATG AATTTTGGGA ACAAGGAGAT CTGGAGAGAA CAGTGTTGCA GCAACAACCC 
ATTCCTATGA TGGACAGAAA CAAAAGAGAT GAATTACCTA AACTTCAAGT TGGATTTATT 
GATTTTGTTT GTACTTTTGT ATATAAGGAG TTCTCACGGT TTCACAAAGA AATCACACCT 
ATGCTGAGTG GTCTTCAGAA TAACAGAGTA GAATGGAAAT CACTAGCTGA TGAGTATGAT 
GCAAAGATGA AGGTCATTGA AGAGGAGGCA AAAAAGCAAG AAGGAGGAGC CGAAAAAGCT 
GCTGAAGATT CAGGAGGTGG TGATGACAAA AAGTCCAAAA CATGTTTAAT GTTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PDE6C ( XM_017016322.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016871811.1 Homo sapiens phosphodiesterase 6C (PDE6C), transcript variant X1, mRNA.

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CloneID	OHu91461
Clone ID Related Accession (Same CDS sequence)	XM_017016322.1
Accession Version	XM_017016322.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1989bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTCCTGT GCCGGTCCCG GAACGGCATA CCTGAGGTGG CCTCTAGGTT GCTGGATGTC 
ACCCCCACCT CCAAGTTTGA GGACAACCTG GTGGGCCCTG ACAAAGAAGT TGTGTTTCCA 
TTGGACATTG GGATAGTGGG TTGGGCTGCT CACACGAAGA AAACTCATAA TGTCCCAGAT 
GTGAAAAAGA TCCTTATGTG GTCAGCCAAT AAAGTATTTG AAGAACTCAC AGATGTTGAG 
CGACAGTTTC ACAAAGCGCT CTACACGGTT AGATCATATC TGAACTGTGA ACGATACTCC 
ATTGGACTGC TGGACATGAC CAAGGAGAAG GAATTCTACG ATGAATGGCC AATCAAGCTT 
GGAGAAGTAG AGCCTTATAA AGGTCCAAAG ACACCTGATG GCAGGGAAGT CAACTTTTAT 
AAAATCATTG ATTACATTTT ACATGGAAAA GAAGAGATCA AAGTGATTCC GACGCCTCCT 
GCAGACCACT GGACACTCAT TAGTGGGTTG CCAACATATG TTGCTGAAAA TGGATTTATC 
TGTAACATGA TGAATGCCCC TGCGGATGAA TACTTCACAT TTCAGAAAGG ACCTGTAGAC 
GAAACTGGTT GGGTCATTAA GAATGTTTTG TCCCTGCCTA TTGTCAACAA GAAAGAAGAT 
ATTGTGGGAG TGGCTACATT TTACAACAGG AAGGATGGAA AACCTTTCGA TGAGCATGAT 
GAATACATTA CCGAGACTCT CACACAATTT CTTGGATGGT CTCTTTTAAA TACTGACACC 
TACGATAAGA TGAATAAGCT AGAAAACAGA AAGGACATTG CTCAGGAAAT GCTCATGAAC 
CAAACCAAAG CCACTCCTGA AGAAATTAAG TCCATTTTGA AATTTCAAGA GAAGTTAAAT 
GTTGATGTAA TTGACGACTG TGAAGAAAAA CAACTTGTTG CAATTTTGAA AGAGGACTTG 
CCAGACCCAC GCTCAGCAGA ACTGTACGAA TTCCGCTTCA GTGACTTCCC CCTTACAGAG 
CACGGATTGA TTAAATGTGG AATACGACTG TTTTTTGAAA TAAATGTGGT GGAGAAATTC 
AAAGTACCTG TAGAGGTTCT TACCAGATGG ATGTACACTG TGAGGAAAGG GTACCGAGCT 
GTCACTTACC ACAATTGGCG GCATGGGTTC AACGTGGGGC AGACCATGTT TACTTTGCTG 
ATGACAGGAA GATTAAAGAA GTACTACACA GATCTCGAAG CCTTTGCCAT GCTTGCTGCT 
GCTTTCTGCC ATGATATTGA CCACAGAGGC ACCAATAATT TGTACCAGAT GAAATCCACG 
TCTCCATTAG CAAGACTTCA TGGTTCTTCT ATTTTGGAGA GGCACCACCT GGAGTACAGT 
AAGACTCTGT TGCAGGATGA GAGTTTAAAC ATCTTCCAGA ACCTAAATAA GCGGCAGTTT 
GAAACAGTTA TTCATTTGTT CGAGGTCGCA ATAATAGCAA CTGACCTGGC TTTATATTTC 
AAGAAGAGGA CCATGTTTCA AAAAATTGTT GATGCCTGTG AACAAATGCA AACGGAAGAA 
GAAGCCATCA AATATGTAAC TGTTGATCCA ACCAAGAAAG AGATTATCAT GGCAATGATG 
ATGACGGCAT GTGACTTGTC TGCTATTACC AAGCCCTGGG AGGTGCAAAG TCAGGTAGCA 
CTTATGGTTG CAAATGAATT TTGGGAACAA GGAGATCTGG AGAGAACAGT GTTGCAGCAA 
CAACCCATTC CTATGATGGA CAGAAACAAA AGAGATGAAT TACCTAAACT TCAAGTTGGA 
TTTATTGATT TTGTTTGTAC TTTTGTATAT AAGGAGTTCT CACGGTTTCA CAAAGAAATC 
ACACCTATGC TGAGTGGTCT TCAGAATAAC AGAGTAGAAT GGAAATCACT AGCTGATGAG 
TATGATGCAA AGATGAAGGT CATTGAAGAG GAGGCAAAAA AGCAAGAAGG AGGAGCCGAA 
AAAGGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016871811.1
CDS	37..2025
Translation	MFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKG

Target ORF information:

RefSeq Version	XM_017016322.1
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphodiesterase 6C (PDE6C), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017016322.1

ORF Insert Sequence:

ATGTTCCTGT GCCGGTCCCG GAACGGCATA CCTGAGGTGG CCTCTAGGTT GCTGGATGTC 
ACCCCCACCT CCAAGTTTGA GGACAACCTG GTGGGCCCTG ACAAAGAAGT TGTGTTTCCA 
TTGGACATTG GGATAGTGGG TTGGGCTGCT CACACGAAGA AAACTCATAA TGTCCCAGAT 
GTGAAAAAGA TCCTTATGTG GTCAGCCAAT AAAGTATTTG AAGAACTCAC AGATGTTGAG 
CGACAGTTTC ACAAAGCGCT CTACACGGTT AGATCATATC TGAACTGTGA ACGATACTCC 
ATTGGACTGC TGGACATGAC CAAGGAGAAG GAATTCTACG ATGAATGGCC AATCAAGCTT 
GGAGAAGTAG AGCCTTATAA AGGTCCAAAG ACACCTGATG GCAGGGAAGT CAACTTTTAT 
AAAATCATTG ATTACATTTT ACATGGAAAA GAAGAGATCA AAGTGATTCC GACGCCTCCT 
GCAGACCACT GGACACTCAT TAGTGGGTTG CCAACATATG TTGCTGAAAA TGGATTTATC 
TGTAACATGA TGAATGCCCC TGCGGATGAA TACTTCACAT TTCAGAAAGG ACCTGTAGAC 
GAAACTGGTT GGGTCATTAA GAATGTTTTG TCCCTGCCTA TTGTCAACAA GAAAGAAGAT 
ATTGTGGGAG TGGCTACATT TTACAACAGG AAGGATGGAA AACCTTTCGA TGAGCATGAT 
GAATACATTA CCGAGACTCT CACACAATTT CTTGGATGGT CTCTTTTAAA TACTGACACC 
TACGATAAGA TGAATAAGCT AGAAAACAGA AAGGACATTG CTCAGGAAAT GCTCATGAAC 
CAAACCAAAG CCACTCCTGA AGAAATTAAG TCCATTTTGA AATTTCAAGA GAAGTTAAAT 
GTTGATGTAA TTGACGACTG TGAAGAAAAA CAACTTGTTG CAATTTTGAA AGAGGACTTG 
CCAGACCCAC GCTCAGCAGA ACTGTACGAA TTCCGCTTCA GTGACTTCCC CCTTACAGAG 
CACGGATTGA TTAAATGTGG AATACGACTG TTTTTTGAAA TAAATGTGGT GGAGAAATTC 
AAAGTACCTG TAGAGGTTCT TACCAGATGG ATGTACACTG TGAGGAAAGG GTACCGAGCT 
GTCACTTACC ACAATTGGCG GCATGGGTTC AACGTGGGGC AGACCATGTT TACTTTGCTG 
ATGACAGGAA GATTAAAGAA GTACTACACA GATCTCGAAG CCTTTGCCAT GCTTGCTGCT 
GCTTTCTGCC ATGATATTGA CCACAGAGGC ACCAATAATT TGTACCAGAT GAAATCCACG 
TCTCCATTAG CAAGACTTCA TGGTTCTTCT ATTTTGGAGA GGCACCACCT GGAGTACAGT 
AAGACTCTGT TGCAGGATGA GAGTTTAAAC ATCTTCCAGA ACCTAAATAA GCGGCAGTTT 
GAAACAGTTA TTCATTTGTT CGAGGTCGCA ATAATAGCAA CTGACCTGGC TTTATATTTC 
AAGAAGAGGA CCATGTTTCA AAAAATTGTT GATGCCTGTG AACAAATGCA AACGGAAGAA 
GAAGCCATCA AATATGTAAC TGTTGATCCA ACCAAGAAAG AGATTATCAT GGCAATGATG 
ATGACGGCAT GTGACTTGTC TGCTATTACC AAGCCCTGGG AGGTGCAAAG TCAGGTAGCA 
CTTATGGTTG CAAATGAATT TTGGGAACAA GGAGATCTGG AGAGAACAGT GTTGCAGCAA 
CAACCCATTC CTATGATGGA CAGAAACAAA AGAGATGAAT TACCTAAACT TCAAGTTGGA 
TTTATTGATT TTGTTTGTAC TTTTGTATAT AAGGAGTTCT CACGGTTTCA CAAAGAAATC 
ACACCTATGC TGAGTGGTCT TCAGAATAAC AGAGTAGAAT GGAAATCACT AGCTGATGAG 
TATGATGCAA AGATGAAGGT CATTGAAGAG GAGGCAAAAA AGCAAGAAGG AGGAGCCGAA 
AAAGGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mechanisms of mutant PDE6 proteins underlying retinal diseases.
Cellular signalling3774-80(2017 Sep)
Gopalakrishna KN,Boyd K,Artemyev NO

Congenital Achromatopsia and Macular Atrophy Caused by a Novel Recessive PDE6C Mutation (p.E591K).
Ophthalmic genetics36(2)137-44(2015 Jun)
Katagiri S,Hayashi T,Yoshitake K,Sergeev Y,Akahori M,Furuno M,Nishino J,Ikeo K,Tsunoda K,Tsuneoka H,Iwata T

Exchange of Cone for Rod Phosphodiesterase 6 Catalytic Subunits in Rod Photoreceptors Mimics in Part Features of Light Adaptation.
The Journal of neuroscience : the official journal of the Society for Neuroscience35(24)9225-35(2015 Jun)
Majumder A,Pahlberg J,Muradov H,Boyd KK,Sampath AP,Artemyev NO

A genome-wide association meta-analysis of preschool internalizing problems.
Journal of the American Academy of Child and Adolescent Psychiatry53(6)667-676.e7(2014 Jun)
Benke KS,Nivard MG,Velders FP,Walters RK,Pappa I,Scheet PA,Xiao X,Ehli EA,Palmer LJ,Whitehouse AJ,Verhulst FC,Jaddoe VW,Rivadeneira F,Groen-Blokhuis MM,van Beijsterveldt CE,Davies GE,Hudziak JJ,Lubke GH,Boomsma DI,Pennell CE,Tiemeier H,Middeldorp CM,

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PDE6C cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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