ATP6V1D cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ATP6V1D
Entrez Gene ID	51382
Full Name	ATPase H+ transporting V1 subunit D
Synonyms	ATP6M,VATD,VMA8
General protein information	Preferred Names ATPase H+ transporting V1 subunit D Names V-type proton ATPase subunit D ATPase, H+ transporting lysosomal, member M ATPase, H+ transporting, lysosomal (vacuolar proton pump) ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D H(+)-transporting two-sector ATPase, subunit M V-ATPase 28 kDa accessory protein V-ATPase D subunit V-ATPase subunit D vacuolar ATP synthase subunit D vacuolar H-ATPase subunit D vacuolar proton pump D subunit vacuolar proton pump delta polypeptide vacuolar proton pump subunit D vacuolar proton-ATPase subunit D
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q23.3
Summary	This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the V1 domain D subunit protein. [provided by RefSeq, Jul 2008].
Disorder MIM:	609398

mRNA and Protein(s)

mRNA	Protein	Name
NM_015994.4	NP_057078.1	V-type proton ATPase subunit D
NM_015994.3	NP_057078.1	V-type proton ATPase subunit D

Pathways from BioSystems

Homologies

Bos taurus (cattle)	ATP6V1D	NP_001068609.2
Gallus gallus (chicken)	ATP6V1D	NP_001264368.1
Kluyveromyces lactis	KLLA0A01991g	XP_451088.1
Homo sapiens (human)	ATP6V1D	NP_057078.1
Mus musculus (house mouse)	Atp6v1d	NP_076210.1
Drosophila melanogaster (fruit fly)	Vha36-1	NP_651987.1
Schizosaccharomyces pombe (fission yeast)	vma8	NP_588513.1
Neurospora crassa	NCU08035	XP_962705.2
Arabidopsis thaliana (thale cress)	AT3G58730	NP_191432.1
Oryza sativa (rice)	Os04g0643100	NP_001054048.1
Pan troglodytes (chimpanzee)	ATP6V1D	XP_001136552.1
Saccharomyces cerevisiae (baker's yeast)	VMA8	NP_010863.1
Rattus norvegicus (Norway rat)	Atp6v1d	NP_955418.1
Danio rerio (zebrafish)	atp6v1d	NP_001161426.1
Caenorhabditis elegans (roundworm)	vha-14	NP_499094.1
Eremothecium gossypii	AGOS_AAR130C	NP_982672.1
	ATP6V1D	XP_001106329.1
Canis lupus familiaris (dog)	ATP6V1D	XP_537484.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010298	XP_318202.3
Magnaporthe oryzae (rice blast fungus)	MGG_07086	XP_003715275.1
Xenopus tropicalis (tropical clawed frog)	atp6v1d	NP_001017075.1

Gene Ontology
Bibliography

Related articles in PubMed

Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns.
Castaldi PJ, Cho MH, San Jos? Est?par R, McDonald ML, Laird N, Beaty TH, Washko G, Crapo JD, Silverman EK,
American journal of respiratory and critical care medicine190(4)399-409(2014 Aug)

Lipofuscin is formed independently of macroautophagy and lysosomal activity in stress-induced prematurely senescent human fibroblasts.
H?hn A, Sittig A, Jung T, Grimm S, Grune T
Free radical biology & medicine53(9)1760-9(2012 Nov)

A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo.
Chen Y, Wu B, Xu L, Li H, Xia J, Yin W, Li Z, Shi D, Li S, Lin S, Shu X, Pei D
Cell research22(2)333-45(2012 Feb)

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S,
Diabetes care33(10)2250-3(2010 Oct)

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, , ,
American journal of human genetics85(5)628-42(2009 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Top single-nucleotide polymorphism rs9590614 in VMA8 is located within genes that function in cell-cell signaling and cell migration.
Title: Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

The following ATP6V1D gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ATP6V1D cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12913	NM_015994.4 Latest version!	Homo sapiens ATPase H+ transporting V1 subunit D (ATP6V1D), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu12913	NM_015994.3	Homo sapiens ATPase H+ transporting V1 subunit D (ATP6V1D), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ATP6V1D ( NM_015994.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057078.1 Homo sapiens ATPase H+ transporting V1 subunit D (ATP6V1D), mRNA.

Price & Availability↑

CloneID	OHu12913
Clone ID Related Accession (Same CDS sequence)	NM_015994.4 , NM_015994.3
Accession Version	NM_015994.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 744bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	V-type proton ATPase subunit D
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB039102.1, BC001411.2, AL139785.5 and BU726615.1. On Nov 23, 2018 this sequence version replaced NM_015994.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.236310.1, SRR1803613.130608.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000216442.12/ ENSP00000216442.7 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCGGGCA AAGACCGAAT TGAAATCTTT CCCTCGCGAA TGGCACAGAC CATCATGAAG 
GCTCGTTTAA AGGGAGCACA GACAGGTCGA AACCTCCTGA AGAAAAAATC TGATGCCTTA 
ACTCTTCGAT TTCGACAGAT CCTAAAGAAG ATAATAGAGA CTAAAATGTT GATGGGCGAA 
GTGATGAGAG AAGCTGCCTT TTCACTAGCT GAAGCCAAGT TCACAGCAGG TGACTTCAGC 
ACTACAGTTA TCCAAAATGT CAATAAAGCG CAAGTGAAGA TTCGAGCGAA GAAAGATAAT 
GTAGCAGGTG TTACTTTGCC AGTATTTGAA CATTACCATG AAGGAACTGA CAGTTATGAA 
CTGACTGGTT TAGCCAGAGG TGGGGAACAG TTGGCTAAAT TAAAGAGGAA TTATGCCAAA 
GCAGTGGAAC TACTGGTGGA ACTAGCTTCT CTGCAGACTT CTTTTGTTAC TTTGGATGAA 
GCTATTAAGA TAACCAACAG GCGTGTAAAT GCCATTGAAC ATGTCATCAT TCCCCGGATT 
GAACGTACTC TTGCTTATAT CATCACAGAG CTGGATGAGA GAGAGCGAGA AGAGTTCTAT 
AGGTTAAAGA AAATACAAGA GAAGAAAAAG ATTCTAAAGG AAAAATCTGA GAAGGACTTG 
GAGCAAAGGA GAGCAGCTGG AGAGGTGTTG GAGCCTGCTA ATCTTCTGGC TGAAGAGAAG 
GACGAGGATC TTCTATTTGA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057078.1
CDS	107..850
Translation	MSGKDRIEIFPSRMAQTIMKARLKGAQTGRNLLKKKSDALTLRFRQILKKIIETKMLMGEVMREAAFSLAEAKFTAGDFSTTVIQNVNKAQVKIRAKKDNVAGVTLPVFEHYHEGTDSYELTGLARGGEQLAKLKRNYAKAVELLVELASLQTSFVTLDEAIKITNRRVNAIEHVIIPRIERTLAYIITELDEREREEFYRLKKIQEKKKILKEKSEKDLEQRRAAGEVLEPANLLAEEKDEDLLFE

Target ORF information:

RefSeq Version	NM_015994.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ATPase H+ transporting V1 subunit D (ATP6V1D), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015994.4

ORF Insert Sequence:

ATGTCGGGCA AAGACCGAAT TGAAATCTTT CCCTCGCGAA TGGCACAGAC CATCATGAAG 
GCTCGTTTAA AGGGAGCACA GACAGGTCGA AACCTCCTGA AGAAAAAATC TGATGCCTTA 
ACTCTTCGAT TTCGACAGAT CCTAAAGAAG ATAATAGAGA CTAAAATGTT GATGGGCGAA 
GTGATGAGAG AAGCTGCCTT TTCACTAGCT GAAGCCAAGT TCACAGCAGG TGACTTCAGC 
ACTACAGTTA TCCAAAATGT CAATAAAGCG CAAGTGAAGA TTCGAGCGAA GAAAGATAAT 
GTAGCAGGTG TTACTTTGCC AGTATTTGAA CATTACCATG AAGGAACTGA CAGTTATGAA 
CTGACTGGTT TAGCCAGAGG TGGGGAACAG TTGGCTAAAT TAAAGAGGAA TTATGCCAAA 
GCAGTGGAAC TACTGGTGGA ACTAGCTTCT CTGCAGACTT CTTTTGTTAC TTTGGATGAA 
GCTATTAAGA TAACCAACAG GCGTGTAAAT GCCATTGAAC ATGTCATCAT TCCCCGGATT 
GAACGTACTC TTGCTTATAT CATCACAGAG CTGGATGAGA GAGAGCGAGA AGAGTTCTAT 
AGGTTAAAGA AAATACAAGA GAAGAAAAAG ATTCTAAAGG AAAAATCTGA GAAGGACTTG 
GAGCAAAGGA GAGCAGCTGG AGAGGTGTTG GAGCCTGCTA ATCTTCTGGC TGAAGAGAAG 
GACGAGGATC TTCTATTTGA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATP6V1D ( NM_015994.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057078.1 Homo sapiens ATPase H+ transporting V1 subunit D (ATP6V1D), mRNA.

Price & Availability↑

CloneID	OHu12913
Clone ID Related Accession (Same CDS sequence)	NM_015994.4 , NM_015994.3
Accession Version	NM_015994.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 744bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	V-type proton ATPase subunit D
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB039102.1, BC001411.2, AL139785.5 and BU726615.1. On Nov 13, 2010 this sequence version replaced NM_015994.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.8727.1, SRR1660803.116236.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGGGCA AAGACCGAAT TGAAATCTTT CCCTCGCGAA TGGCACAGAC CATCATGAAG 
GCTCGTTTAA AGGGAGCACA GACAGGTCGA AACCTCCTGA AGAAAAAATC TGATGCCTTA 
ACTCTTCGAT TTCGACAGAT CCTAAAGAAG ATAATAGAGA CTAAAATGTT GATGGGCGAA 
GTGATGAGAG AAGCTGCCTT TTCACTAGCT GAAGCCAAGT TCACAGCAGG TGACTTCAGC 
ACTACAGTTA TCCAAAATGT CAATAAAGCG CAAGTGAAGA TTCGAGCGAA GAAAGATAAT 
GTAGCAGGTG TTACTTTGCC AGTATTTGAA CATTACCATG AAGGAACTGA CAGTTATGAA 
CTGACTGGTT TAGCCAGAGG TGGGGAACAG TTGGCTAAAT TAAAGAGGAA TTATGCCAAA 
GCAGTGGAAC TACTGGTGGA ACTAGCTTCT CTGCAGACTT CTTTTGTTAC TTTGGATGAA 
GCTATTAAGA TAACCAACAG GCGTGTAAAT GCCATTGAAC ATGTCATCAT TCCCCGGATT 
GAACGTACTC TTGCTTATAT CATCACAGAG CTGGATGAGA GAGAGCGAGA AGAGTTCTAT 
AGGTTAAAGA AAATACAAGA GAAGAAAAAG ATTCTAAAGG AAAAATCTGA GAAGGACTTG 
GAGCAAAGGA GAGCAGCTGG AGAGGTGTTG GAGCCTGCTA ATCTTCTGGC TGAAGAGAAG 
GACGAGGATC TTCTATTTGA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057078.1
CDS	306..1049
Translation	MSGKDRIEIFPSRMAQTIMKARLKGAQTGRNLLKKKSDALTLRFRQILKKIIETKMLMGEVMREAAFSLAEAKFTAGDFSTTVIQNVNKAQVKIRAKKDNVAGVTLPVFEHYHEGTDSYELTGLARGGEQLAKLKRNYAKAVELLVELASLQTSFVTLDEAIKITNRRVNAIEHVIIPRIERTLAYIITELDEREREEFYRLKKIQEKKKILKEKSEKDLEQRRAAGEVLEPANLLAEEKDEDLLFE

Target ORF information:

RefSeq Version	NM_015994.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ATPase H+ transporting V1 subunit D (ATP6V1D), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015994.3

ORF Insert Sequence:

ATGTCGGGCA AAGACCGAAT TGAAATCTTT CCCTCGCGAA TGGCACAGAC CATCATGAAG 
GCTCGTTTAA AGGGAGCACA GACAGGTCGA AACCTCCTGA AGAAAAAATC TGATGCCTTA 
ACTCTTCGAT TTCGACAGAT CCTAAAGAAG ATAATAGAGA CTAAAATGTT GATGGGCGAA 
GTGATGAGAG AAGCTGCCTT TTCACTAGCT GAAGCCAAGT TCACAGCAGG TGACTTCAGC 
ACTACAGTTA TCCAAAATGT CAATAAAGCG CAAGTGAAGA TTCGAGCGAA GAAAGATAAT 
GTAGCAGGTG TTACTTTGCC AGTATTTGAA CATTACCATG AAGGAACTGA CAGTTATGAA 
CTGACTGGTT TAGCCAGAGG TGGGGAACAG TTGGCTAAAT TAAAGAGGAA TTATGCCAAA 
GCAGTGGAAC TACTGGTGGA ACTAGCTTCT CTGCAGACTT CTTTTGTTAC TTTGGATGAA 
GCTATTAAGA TAACCAACAG GCGTGTAAAT GCCATTGAAC ATGTCATCAT TCCCCGGATT 
GAACGTACTC TTGCTTATAT CATCACAGAG CTGGATGAGA GAGAGCGAGA AGAGTTCTAT 
AGGTTAAAGA AAATACAAGA GAAGAAAAAG ATTCTAAAGG AAAAATCTGA GAAGGACTTG 
GAGCAAAGGA GAGCAGCTGG AGAGGTGTTG GAGCCTGCTA ATCTTCTGGC TGAAGAGAAG 
GACGAGGATC TTCTATTTGA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns.
American journal of respiratory and critical care medicine190(4)399-409(2014 Aug)
Castaldi PJ,Cho MH,San Jos? Est?par R,McDonald ML,Laird N,Beaty TH,Washko G,Crapo JD,Silverman EK,

Lipofuscin is formed independently of macroautophagy and lysosomal activity in stress-induced prematurely senescent human fibroblasts.
Free radical biology & medicine53(9)1760-9(2012 Nov)
H?hn A,Sittig A,Jung T,Grimm S,Grune T

A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo.
Cell research22(2)333-45(2012 Feb)
Chen Y,Wu B,Xu L,Li H,Xia J,Yin W,Li Z,Shi D,Li S,Lin S,Shu X,Pei D

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Diabetes care33(10)2250-3(2010 Oct)
Bailey SD,Xie C,Do R,Montpetit A,Diaz R,Mohan V,Keavney B,Yusuf S,Gerstein HC,Engert JC,Anand S,

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
American journal of human genetics85(5)628-42(2009 Nov)
Talmud PJ,Drenos F,Shah S,Shah T,Palmen J,Verzilli C,Gaunt TR,Pallas J,Lovering R,Li K,Casas JP,Sofat R,Kumari M,Rodriguez S,Johnson T,Newhouse SJ,Dominiczak A,Samani NJ,Caulfield M,Sever P,Stanton A,Shields DC,Padmanabhan S,Melander O,Hastie C,Delles C,Ebrahim S,Marmot MG,Smith GD,Lawlor DA,Munroe PB,Day IN,Kivimaki M,Whittaker J,Humphries SE,Hingorani AD,,,

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ATP6V1D cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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